Issue running with all cosmic signatures?

[lmckinno]

Hello, I am trying to use the mmsig example from the README but using all reference signatures. It hasn't finished this short example in the past hour, my guess is that it may be in an endless while loop. Any thoughts? Below is the code I ran:

library(mmsig)
library(MutationalPatterns)
data(mm_5_col)
data(signature_ref)

#Get known signatures
data(signature_ref)
signatures = get_known_signatures()
all_sigs <- cbind(signature_ref[c("sub","tri")],signatures)

sig_out <- mm_fit_signatures(muts.input=mm_5_col_subset[1:50,],
sig.input=all_sigs,
input.format = "vcf",
sample.sigt.profs = NULL,
strandbias = TRUE,
bootstrap = TRUE,
iterations = 20, # 1000 iterations recommended for stable results
refcheck=TRUE,
cos_sim_threshold = 0.01,
dbg=FALSE)