diff --git a/packages/mambajs/src/solver.ts b/packages/mambajs/src/solver.ts
index 74a5cb6..b05182a 100644
--- a/packages/mambajs/src/solver.ts
+++ b/packages/mambajs/src/solver.ts
@@ -19,6 +19,29 @@ export interface ISolveOptions {
   nRetries?: number;
 }
 
+const VIRTUAL_PACKAGES = {
+  __unix: makeVirtualPackage('__unix'),
+  __linux: makeVirtualPackage('__linux'),
+  __glibc: makeVirtualPackage('__glibc', '2.25'),
+  __osx: makeVirtualPackage('__osx'),
+  __win: makeVirtualPackage('__win'),
+  __archspec: makeVirtualPackage('__archspec')
+};
+
+function makeVirtualPackage(name: string, version='0') {
+  return {
+    filename: name,
+    packageName: name,
+    repoName: '@',
+    version,
+    build: '@',
+    subdir: '@',
+    md5: '@',
+    sha256: '@',
+    url: 'https://prefix.dev/@/@'
+  };
+}
+
 export const solveConda = async (options: ISolveOptions): Promise<ILock> => {
   const { ymlOrSpecs, currentLock, logger } = options;
   const platform = options.platform ?? DEFAULT_PLATFORM;
@@ -48,6 +71,50 @@ export const solveConda = async (options: ISolveOptions): Promise<ILock> => {
     logger.log('Solving environment...');
   }
 
+  const installedPackages = Object.keys(installedCondaPackages).map(
+    (filename: string) => {
+      // Turn mambajs lock definition into what rattler expects
+      const installedPkg = installedCondaPackages[filename];
+      return {
+        filename,
+        packageName: installedPkg.name,
+        repoName: installedPkg.channel,
+        version: installedPkg.version,
+        build: installedPkg.build,
+        subdir: installedPkg.subdir,
+        md5: installedPkg.hash?.md5,
+        sha256: installedPkg.hash?.sha256,
+        url: computePackageUrl(
+          installedPkg,
+          filename,
+          formattedChannels.channelInfo
+        )
+      };
+    }
+  );
+
+  // Inject virtual packages
+  if (
+    platform.includes('wasm') ||
+    platform.includes('linux') ||
+    platform.includes('osx') ||
+    platform.includes('zos') ||
+    platform.includes('freebsd')
+  ) {
+    installedPackages.push(VIRTUAL_PACKAGES['__unix']);
+  }
+  if (platform.includes('linux')) {
+    installedPackages.push(VIRTUAL_PACKAGES['__linux']);
+    installedPackages.push(VIRTUAL_PACKAGES['__glibc']);
+  }
+  if (platform.includes('osx')) {
+    installedPackages.push(VIRTUAL_PACKAGES['__osx']);
+  }
+  if (platform.includes('win')) {
+    installedPackages.push(VIRTUAL_PACKAGES['__win']);
+  }
+  installedPackages.push(VIRTUAL_PACKAGES['__archspec']);
+
   try {
     const startSolveTime = performance.now();
 
@@ -59,25 +126,7 @@ export const solveConda = async (options: ISolveOptions): Promise<ILock> => {
         return formattedChannels.channelInfo[channelName][0].url;
       }),
       ['noarch', platform],
-      Object.keys(installedCondaPackages).map((filename: string) => {
-        // Turn mambajs lock definition into what rattler expects
-        const installedPkg = installedCondaPackages[filename];
-        return {
-          filename,
-          packageName: installedPkg.name,
-          repoName: installedPkg.channel,
-          version: installedPkg.version,
-          build: installedPkg.build,
-          subdir: installedPkg.subdir,
-          md5: installedPkg.hash?.md5,
-          sha256: installedPkg.hash?.sha256,
-          url: computePackageUrl(
-            installedPkg,
-            filename,
-            formattedChannels.channelInfo
-          )
-        };
-      })
+      installedPackages
     )) as SolvedPackage[];
 
     const endSolveTime = performance.now();
@@ -99,6 +148,10 @@ export const solveConda = async (options: ISolveOptions): Promise<ILock> => {
         sha256
       } = item;
 
+      if (filename in VIRTUAL_PACKAGES) {
+        return;
+      }
+
       const hash: ILock['packages'][string]['hash'] = {};
       if (md5) hash.md5 = md5;
       if (sha256) hash.sha256 = sha256;
diff --git a/unittests/tests/conda/test-virtual-packages.ts b/unittests/tests/conda/test-virtual-packages.ts
new file mode 100644
index 0000000..93222c1
--- /dev/null
+++ b/unittests/tests/conda/test-virtual-packages.ts
@@ -0,0 +1,92 @@
+import { ISolvedPackage, solve } from "../../../packages/mambajs/src";
+import { TestLogger } from "../../helpers";
+import { expect } from 'earl';
+
+const logger = new TestLogger();
+
+let yml = `
+channels:
+  - https://prefix.dev/emscripten-forge-dev
+  - https://prefix.dev/conda-forge
+dependencies:
+  # click requires __unix
+  - click>=8.3.1
+`;
+
+solve({ymlOrSpecs: yml, logger}).then(async result => {
+  const packageNames = Object.values(result.packages).map(pkg => pkg.name);
+
+  // Index by package name for convenienve
+  const condaPackages: { [key: string]: ISolvedPackage } = {};
+  Object.keys(result.packages).map(filename => {
+    condaPackages[result.packages[filename].name] =
+      result.packages[filename];
+  });
+
+  expect(packageNames).toInclude('click');
+});
+
+yml = `
+channels:
+  - https://prefix.dev/emscripten-forge-4x
+  - https://prefix.dev/conda-forge
+dependencies:
+  # click requires __unix
+  - click>=8.3.1
+`;
+
+solve({ymlOrSpecs: yml, logger}).then(async result => {
+  const packageNames = Object.values(result.packages).map(pkg => pkg.name);
+
+  // Index by package name for convenienve
+  const condaPackages: { [key: string]: ISolvedPackage } = {};
+  Object.keys(result.packages).map(filename => {
+    condaPackages[result.packages[filename].name] =
+      result.packages[filename];
+  });
+
+  expect(packageNames).toInclude('click');
+});
+
+yml = `
+channels:
+  - https://prefix.dev/conda-forge
+dependencies:
+  # click requires __unix
+  - click>=8.3.1
+`;
+
+solve({ymlOrSpecs: yml, logger, platform: "linux-64"}).then(async result => {
+  const packageNames = Object.values(result.packages).map(pkg => pkg.name);
+
+  // Index by package name for convenienve
+  const condaPackages: { [key: string]: ISolvedPackage } = {};
+  Object.keys(result.packages).map(filename => {
+    condaPackages[result.packages[filename].name] =
+      result.packages[filename];
+  });
+
+  expect(packageNames).toInclude('click');
+});
+
+yml = `
+channels:
+  - https://prefix.dev/conda-forge
+dependencies:
+  # oracle-instant-client requires __glibc
+  - oracle-instant-client
+`;
+
+solve({ymlOrSpecs: yml, logger, platform: "linux-64"}).then(async result => {
+  const packageNames = Object.values(result.packages).map(pkg => pkg.name);
+
+  // Index by package name for convenienve
+  const condaPackages: { [key: string]: ISolvedPackage } = {};
+  Object.keys(result.packages).map(filename => {
+    condaPackages[result.packages[filename].name] =
+      result.packages[filename];
+  });
+
+  expect(packageNames).toInclude('oracle-instant-client');
+});
+