From 41e4b2f3b7bbcc9d19c8b33b8db316b5f2f7e036 Mon Sep 17 00:00:00 2001 From: saamm Date: Wed, 30 Aug 2017 16:39:02 +0530 Subject: [PATCH 1/7] Added a new file there are errors in the rows that are getting printed --- dataonco.py | 90 +++++++++++++++++++++++++++++++++++++++++++++++++++++ 1 file changed, 90 insertions(+) create mode 100644 dataonco.py diff --git a/dataonco.py b/dataonco.py new file mode 100644 index 0000000..6aff801 --- /dev/null +++ b/dataonco.py @@ -0,0 +1,90 @@ +import csv +import pymysql +pymysql.install_as_MySQLdb() +import MySQLdb +from urllib.request import urlretrieve +import os + +url = "http://oncokb.org/api/v1/utils/allAnnotatedVariants.txt" +urlretrieve(url,"oncotxt.txt") + +with open('oncotxt.txt', 'r') as infile, open('oncocsv.csv', 'w') as outfile: + in_txt = csv.reader(infile, delimiter = '\t') + out_csv = csv.writer(outfile) + out_csv.writerows(in_txt) + +os.remove('oncotxt.txt') + +def MapOncokb(d): + d['Database'] = 'OncoKB' + d['Mutation'] = 0 + d['Signature'] = 1 + d['Variant'] = 99999 + d['Functionality'] = 3 + d['Impact'] = 99999 + d['Indication'] = 99999 + d['Domain'] = 99999 + d['Classification'] = 99999 + d['Reference'] = 4 + + return d + +def MapFunctionality(str): + functionality = { # OncoKB map + 'Loss-of-function': 'LOF', 'Likely Loss-of-function': 'LOF', + 'Gain-of-function': 'GOF', 'Likely Gain-of-function': 'GOF', + 'Switch-of-function': 'SOF', 'Likely Switch-of-function': 'SOF', + 'Mutation Effect': 'COF', 'Likely Mutation Effect': 'COF', + 'Inconclusive': 'Inconclusive', + 'Neutral': 'Neutral', 'Likely Neutral': 'Neutral', + # + } + + return functionality[str.strip()] + + +def WriteDB(dbFd, dbMap, row): + tblRow = 10*['NA'] + + tblRow[0] = dbMap['Database'] + tblRow[1] = row [dbMap['Mutation']] + tblRow[2] = (row [dbMap['Signature']]) + if (dbMap['Variant'] != 99999): + tblRow[3] = (row [dbMap['Variant']]) + if (dbMap['Functionality'] != 99999): + tblRow[4] = MapFunctionality (row [dbMap['Functionality']]) + if (dbMap['Impact'] != 99999): + tblRow[5] = row [dbMap['Impact']] + if (dbMap['Indication'] != 99999): + tblRow[6] = row [dbMap['Indication']] + if (dbMap['Domain'] != 99999): + tblRow[7] = row [dbMap['Domain']] + if (dbMap['Classification'] != 99999): + tblRow[8] = row [dbMap['Classification']] + if (dbMap['Reference'] != 99999): + tblRow[9] = row [dbMap['Reference']] + + return tblRow + +dbFd = 1 + + +database = MySQLdb.connect(host='localhost', user='root', passwd='root') +cursor = database.cursor() +create_database = "CREATE DATABASE IF NOT EXISTS cellworksdata" +cursor.execute(create_database) +database = MySQLdb.connect(host='localhost', user='root', passwd='root', db='cellworks') +cursor = database.cursor() +create_table = "CREATE TABLE IF NOT EXISTS cellworkstable (Data VARCHAR(255), Mutation VARCHAR(255), Signature VARCHAR(255), Variant VARCHAR(255), Functionality VARCHAR(255), Impact VARCHAR(255), Indication VARCHAR(255), Domain VARCHAR(255), Classification VARCHAR(255), Reference VARCHAR(255))" +cursor.execute(create_table) +with open('oncocsv.csv', "r") as file: + reader = csv.reader(file) + for row in reader: + if len(row) == 10: + cursor.execute('INSERT INTO cellworkstable (Data,Mutation,Signature,Variant,Functionality,Impact,Indication,Domain,Classification,Reference) VALUES("%s","%s","%s","%s","%s","%s","%s","%s","%s","%s")', (row[0], row[1], row[2], row[3], row[4], row[5], row[6], row[7], row[8], row[9])) + else: + print('Error in row: ') + print(row) +database.commit() +cursor.close() +os.remove('oncocsv.csv') \ No newline at end of file From 7827f6a2d1cef6d7665cb52e33596a2128af43cb Mon Sep 17 00:00:00 2001 From: saamm Date: Wed, 30 Aug 2017 17:16:17 +0530 Subject: [PATCH 2/7] line 52 tblRow[2] = row [dbMap['SIgnature']] is showing an IndexError --- dataonco.py | 15 +++++++++++++-- 1 file changed, 13 insertions(+), 2 deletions(-) diff --git a/dataonco.py b/dataonco.py index 6aff801..fcb3173 100644 --- a/dataonco.py +++ b/dataonco.py @@ -48,7 +48,7 @@ def WriteDB(dbFd, dbMap, row): tblRow[0] = dbMap['Database'] tblRow[1] = row [dbMap['Mutation']] - tblRow[2] = (row [dbMap['Signature']]) + tblRow[2] = row [dbMap['Signature']] if (dbMap['Variant'] != 99999): tblRow[3] = (row [dbMap['Variant']]) if (dbMap['Functionality'] != 99999): @@ -68,6 +68,17 @@ def WriteDB(dbFd, dbMap, row): dbFd = 1 +myfile = open('/home/soumya/cellworks/finalrecord.csv', 'w') +writer = csv.writer(myfile, delimiter=',') + +oncoMap = dict(); +MapOncokb(oncoMap) +with open('/home/soumya/cellworks/oncocsv.csv', 'r') as csvFd: + reader = csv.reader(csvFd, delimiter='\t') + for row in reader: + lin = WriteDB(dbFd, oncoMap, row) + writer.writerow(lin) + database = MySQLdb.connect(host='localhost', user='root', passwd='root') cursor = database.cursor() @@ -87,4 +98,4 @@ def WriteDB(dbFd, dbMap, row): print(row) database.commit() cursor.close() -os.remove('oncocsv.csv') \ No newline at end of file +os.remove('oncocsv.csv') From 2af38e36e7197ed4d80d7e676e00e4f03a7d05fc Mon Sep 17 00:00:00 2001 From: saamm Date: Wed, 30 Aug 2017 17:31:31 +0530 Subject: [PATCH 3/7] modification --- db_collate.py | 15 +++++++-------- 1 file changed, 7 insertions(+), 8 deletions(-) diff --git a/db_collate.py b/db_collate.py index b24a413..60df2af 100644 --- a/db_collate.py +++ b/db_collate.py @@ -110,24 +110,23 @@ def WriteDB(dbFd, dbMap, row): return tblRow - ## main() dbFd = 1 # stdout will be the 'DB' for now. -myfile = open('final_record.csv', 'wb+') +myfile = open('/home/soumya/cellworks/final_record.csv', 'wb+') writer = csv.writer(myfile, delimiter=',') oncoMap = dict(); MapOncokb(oncoMap) -with open('oncoKB_tmp.csv', 'rb') as csvFd: +with open('/home/soumya/cellworks/oncoKB_tmp.csv', 'rb') as csvFd: reader = csv.reader(csvFd, delimiter='\t') for row in reader: lin = WriteDB(dbFd, oncoMap, row) writer.writerow(lin) civicMap = dict() MapCivic(civicMap) -with open('civic_tmp.csv', 'rb') as csvFd: +with open('/home/soumya/cellworks/civic_tmp.csv', 'rb') as csvFd: reader = csv.reader(csvFd, delimiter='\t') for row in reader: lin = WriteDB(dbFd, civicMap, row) @@ -135,7 +134,7 @@ def WriteDB(dbFd, dbMap, row): synapseMap = dict() MapSynapse(synapseMap) -with open('synapse_tmp.csv', 'rb') as csvFd: +with open('/home/soumya/cellworks/synapse_tmp.csv', 'rb') as csvFd: reader = csv.reader(csvFd, delimiter=',') for row in reader: lin = WriteDB(dbFd, synapseMap, row) @@ -145,11 +144,11 @@ def WriteDB(dbFd, dbMap, row): #Store final data in mysql database. -database = MySQLdb.connect(host='localhost', user='root', passwd='admin123') +database = MySQLdb.connect(host='localhost', user='root', passwd='root') cursor = database.cursor() create_database = "CREATE DATABASE IF NOT EXISTS cellworks" cursor.execute(create_database) -database = MySQLdb.connect(host='localhost', user='root', passwd='admin123', db='cellworks') +database = MySQLdb.connect(host='localhost', user='root', passwd='root', db='cellworks') cursor = database.cursor() create_table = "CREATE TABLE IF NOT EXISTS final_data (Data VARCHAR(255), Mutation VARCHAR(255), Signature VARCHAR(255), Varient VARCHAR(255), Functionality VARCHAR(255), Impact VARCHAR(255), Indication VARCHAR(255), Domain VARCHAR(255), Classification VARCHAR(255), Refrence VARCHAR(255))" cursor.execute(create_table) @@ -159,4 +158,4 @@ def WriteDB(dbFd, dbMap, row): cursor.execute('INSERT INTO final_data (Data,Mutation,Signature,Varient,Functionality,Impact,Indication,Domain,Classification,Refrence) VALUES("%s","%s","%s","%s","%s","%s","%s","%s","%s","%s")', (row[0], row[1], row[2], row[3], row[4], row[5], row[6], row[7], row[8], row[9])) #print row database.commit() -cursor.close() \ No newline at end of file +cursor.close() From 577f1eb006ac499834518bc299896a03419946d3 Mon Sep 17 00:00:00 2001 From: saamm Date: Thu, 31 Aug 2017 17:44:23 +0530 Subject: [PATCH 4/7] The automated program for oncoKB --- dataonco.py | 43 +++++++++++++++++++++++++++++-------------- 1 file changed, 29 insertions(+), 14 deletions(-) mode change 100644 => 100755 dataonco.py diff --git a/dataonco.py b/dataonco.py old mode 100644 new mode 100755 index fcb3173..eee1599 --- a/dataonco.py +++ b/dataonco.py @@ -5,15 +5,23 @@ from urllib.request import urlretrieve import os + url = "http://oncokb.org/api/v1/utils/allAnnotatedVariants.txt" urlretrieve(url,"oncotxt.txt") -with open('oncotxt.txt', 'r') as infile, open('oncocsv.csv', 'w') as outfile: +with open('oncotxt.txt', 'r') as infile, open('test.csv', 'w') as outfile: in_txt = csv.reader(infile, delimiter = '\t') + out_csv = csv.writer(outfile) out_csv.writerows(in_txt) - +with open("test.csv",'r') as f: + with open("oncocsv.csv",'w') as f1: + next(f) # skip header line + for line in f: + f1.write(line) + os.remove('oncotxt.txt') +os.remove('test.csv') def MapOncokb(d): d['Database'] = 'OncoKB' @@ -36,23 +44,25 @@ def MapFunctionality(str): 'Switch-of-function': 'SOF', 'Likely Switch-of-function': 'SOF', 'Mutation Effect': 'COF', 'Likely Mutation Effect': 'COF', 'Inconclusive': 'Inconclusive', - 'Neutral': 'Neutral', 'Likely Neutral': 'Neutral', - # + 'Neutral': 'Neutral', 'Likely Neutral': 'Neutral', 'null': 'NA', + # + } return functionality[str.strip()] def WriteDB(dbFd, dbMap, row): + tblRow = 10*['NA'] tblRow[0] = dbMap['Database'] tblRow[1] = row [dbMap['Mutation']] - tblRow[2] = row [dbMap['Signature']] + tblRow[2] = row [dbMap['Signature']] if (dbMap['Variant'] != 99999): tblRow[3] = (row [dbMap['Variant']]) if (dbMap['Functionality'] != 99999): - tblRow[4] = MapFunctionality (row [dbMap['Functionality']]) + tblRow[4] = MapFunctionality (row [dbMap['Functionality']]) if (dbMap['Impact'] != 99999): tblRow[5] = row [dbMap['Impact']] if (dbMap['Indication'] != 99999): @@ -64,31 +74,35 @@ def WriteDB(dbFd, dbMap, row): if (dbMap['Reference'] != 99999): tblRow[9] = row [dbMap['Reference']] - return tblRow + return tblRow dbFd = 1 -myfile = open('/home/soumya/cellworks/finalrecord.csv', 'w') +myfile = open('finalrecord.csv', 'w') writer = csv.writer(myfile, delimiter=',') -oncoMap = dict(); +oncoMap = dict() MapOncokb(oncoMap) -with open('/home/soumya/cellworks/oncocsv.csv', 'r') as csvFd: - reader = csv.reader(csvFd, delimiter='\t') - for row in reader: + + +with open('oncocsv.csv', 'r') as csvFd: + reader = csv.reader(csvFd, delimiter=',') + for row in reader: + lin = WriteDB(dbFd, oncoMap, row) writer.writerow(lin) + database = MySQLdb.connect(host='localhost', user='root', passwd='root') cursor = database.cursor() create_database = "CREATE DATABASE IF NOT EXISTS cellworksdata" cursor.execute(create_database) -database = MySQLdb.connect(host='localhost', user='root', passwd='root', db='cellworks') +database = MySQLdb.connect(host='localhost', user='root', passwd='root', db='cellworksdata') cursor = database.cursor() create_table = "CREATE TABLE IF NOT EXISTS cellworkstable (Data VARCHAR(255), Mutation VARCHAR(255), Signature VARCHAR(255), Variant VARCHAR(255), Functionality VARCHAR(255), Impact VARCHAR(255), Indication VARCHAR(255), Domain VARCHAR(255), Classification VARCHAR(255), Reference VARCHAR(255))" cursor.execute(create_table) -with open('oncocsv.csv', "r") as file: +with open('finalrecord.csv', "r") as file: reader = csv.reader(file) for row in reader: if len(row) == 10: @@ -99,3 +113,4 @@ def WriteDB(dbFd, dbMap, row): database.commit() cursor.close() os.remove('oncocsv.csv') +os.remove('finalrecord.csv') From 06424c648b3d3b79073fe8624229ddfffc5ea2dc Mon Sep 17 00:00:00 2001 From: saamm Date: Mon, 4 Sep 2017 10:38:06 +0530 Subject: [PATCH 5/7] modify --- README.md | 0 civic_tmp.csv | 0 dataonco.py | 23 +- db_collate.py | 161 -- oncoKB_tmp.csv | 7403 +++++++++++++++++++++++------------------------ synapse_tmp.csv | 0 6 files changed, 3712 insertions(+), 3875 deletions(-) mode change 100644 => 100755 README.md mode change 100644 => 100755 civic_tmp.csv delete mode 100644 db_collate.py mode change 100644 => 100755 oncoKB_tmp.csv mode change 100644 => 100755 synapse_tmp.csv diff --git a/README.md b/README.md old mode 100644 new mode 100755 diff --git a/civic_tmp.csv b/civic_tmp.csv old mode 100644 new mode 100755 diff --git a/dataonco.py b/dataonco.py index eee1599..426ada5 100755 --- a/dataonco.py +++ b/dataonco.py @@ -9,19 +9,18 @@ url = "http://oncokb.org/api/v1/utils/allAnnotatedVariants.txt" urlretrieve(url,"oncotxt.txt") -with open('oncotxt.txt', 'r') as infile, open('test.csv', 'w') as outfile: +with open('oncotxt.txt', 'r') as infile, open('oncocsv.csv', 'w') as outfile: in_txt = csv.reader(infile, delimiter = '\t') out_csv = csv.writer(outfile) out_csv.writerows(in_txt) -with open("test.csv",'r') as f: +'''with open("test.csv",'r') as f: with open("oncocsv.csv",'w') as f1: next(f) # skip header line for line in f: - f1.write(line) + f1.write(line)''' os.remove('oncotxt.txt') -os.remove('test.csv') def MapOncokb(d): d['Database'] = 'OncoKB' @@ -87,30 +86,30 @@ def WriteDB(dbFd, dbMap, row): with open('oncocsv.csv', 'r') as csvFd: reader = csv.reader(csvFd, delimiter=',') - for row in reader: - + next(reader) + for row in reader: lin = WriteDB(dbFd, oncoMap, row) writer.writerow(lin) +os.remove('oncocsv.csv') - database = MySQLdb.connect(host='localhost', user='root', passwd='root') cursor = database.cursor() -create_database = "CREATE DATABASE IF NOT EXISTS cellworksdata" +create_database = "CREATE DATABASE IF NOT EXISTS cellworksDATA" cursor.execute(create_database) -database = MySQLdb.connect(host='localhost', user='root', passwd='root', db='cellworksdata') +database = MySQLdb.connect(host='localhost', user='root', passwd='root', db='cellworksDATA') cursor = database.cursor() -create_table = "CREATE TABLE IF NOT EXISTS cellworkstable (Data VARCHAR(255), Mutation VARCHAR(255), Signature VARCHAR(255), Variant VARCHAR(255), Functionality VARCHAR(255), Impact VARCHAR(255), Indication VARCHAR(255), Domain VARCHAR(255), Classification VARCHAR(255), Reference VARCHAR(255))" +create_table = "CREATE TABLE IF NOT EXISTS cellworksTABLE (Data VARCHAR(255), Mutation VARCHAR(255), Signature VARCHAR(255), Variant VARCHAR(255), Functionality VARCHAR(255), Impact VARCHAR(255), Indication VARCHAR(255), Domain VARCHAR(255), Classification VARCHAR(255), Reference VARCHAR(255))" cursor.execute(create_table) with open('finalrecord.csv', "r") as file: reader = csv.reader(file) for row in reader: if len(row) == 10: - cursor.execute('INSERT INTO cellworkstable (Data,Mutation,Signature,Variant,Functionality,Impact,Indication,Domain,Classification,Reference) VALUES("%s","%s","%s","%s","%s","%s","%s","%s","%s","%s")', (row[0], row[1], row[2], row[3], row[4], row[5], row[6], row[7], row[8], row[9])) + cursor.execute('INSERT INTO cellworksTABLE (Data,Mutation,Signature,Variant,Functionality,Impact,Indication,Domain,Classification,Reference) VALUES("%s","%s","%s","%s","%s","%s","%s","%s","%s","%s")', (row[0], row[1], row[2], row[3], row[4], row[5], row[6], row[7], row[8], row[9])) else: print('Error in row: ') print(row) database.commit() cursor.close() -os.remove('oncocsv.csv') + os.remove('finalrecord.csv') diff --git a/db_collate.py b/db_collate.py deleted file mode 100644 index 60df2af..0000000 --- a/db_collate.py +++ /dev/null @@ -1,161 +0,0 @@ -# db_collate.py -- Collate Oncokb, synapse, civic and docm gene databases -# -# Last Modified: Mon Aug 21 18:43:52 UTC 2017 -# - -import csv -import MySQLdb - - -# Index of each field in OncoKB mapped to standard table fmt. -# -def MapOncokb(d): - d['Database'] = 'OncoKB' - d['Mutation'] = 0 - d['Signature'] = 1 - d['Variant'] = 99999 - d['Functionality'] = 3 - d['Impact'] = 99999 - d['Indication'] = 99999 - d['Domain'] = 99999 - d['Classification'] = 99999 - d['Reference'] = 4 - - return d - - - - -# Index of each field in Civic DB mapped to standard table fmt. -# -def MapCivic(d): - d['Database'] = 'Civic' - d['Mutation'] = 0 - d['Signature'] = 2 - d['Variant'] = 3 - d['Functionality'] = 99999 - d['Impact'] = 99999 - d['Indication'] = 99999 - d['Domain'] = 99999 - d['Classification'] = 99999 - d['Reference'] = 11 - - return d - -# # Index of each field in Synapse DB mapped to standard table fmt. -# # -def MapSynapse(d): - d['Database'] = 'Synapse' - d['Mutation'] = 1 - d['Signature'] = 2 - d['Variant'] = 3 - d['Functionality'] = 4 - d['Impact'] = 99999 - d['Indication'] = 99999 - d['Domain'] = 99999 - d['Classification'] = 99999 - d['Reference'] = 9 - - return d - - - -# Standardise fuctionality to LOF, GOF, etc in the various DB's -def MapFunctionality(str): - functionality = { # OncoKB map - 'Loss-of-function': 'LOF', 'Likely Loss-of-function': 'LOF', - 'Gain-of-function': 'GOF', 'Likely Gain-of-function': 'GOF', - 'Switch-of-function': 'SOF', 'Likely Switch-of-function': 'SOF', - 'Mutation Effect': 'COF', 'Likely Mutation Effect': 'COF', - 'Inconclusive': 'Inconclusive', - 'Neutral': 'Neutral', 'Likely Neutral': 'Neutral', - # - #synapse - 'gain-of-function': 'GOF', 'gain-of-function (low activity)': 'GOF', - 'loss-of-function' : 'LOF', 'switch-of-function': 'SOF', - 'reduced kinase activity':'LOF', - 'not applicable': 'NA', - # - } - - return functionality[str.strip()] - - - - -# Copy over the row from CSV to standard fmt and then write it out. -# Note: Currently simply writes to stdout. -# -def WriteDB(dbFd, dbMap, row): - tblRow = 10*['NA'] - - tblRow[0] = dbMap['Database'] - tblRow[1] = row [dbMap['Mutation']] - tblRow[2] = (row [dbMap['Signature']]) - if (dbMap['Variant'] != 99999): - tblRow[3] = (row [dbMap['Variant']]) - if (dbMap['Functionality'] != 99999): - tblRow[4] = MapFunctionality (row [dbMap['Functionality']]) - if (dbMap['Impact'] != 99999): - tblRow[5] = row [dbMap['Impact']] - if (dbMap['Indication'] != 99999): - tblRow[6] = row [dbMap['Indication']] - if (dbMap['Domain'] != 99999): - tblRow[7] = row [dbMap['Domain']] - if (dbMap['Classification'] != 99999): - tblRow[8] = row [dbMap['Classification']] - if (dbMap['Reference'] != 99999): - tblRow[9] = row [dbMap['Reference']] - - return tblRow - - -## main() - -dbFd = 1 # stdout will be the 'DB' for now. - -myfile = open('/home/soumya/cellworks/final_record.csv', 'wb+') -writer = csv.writer(myfile, delimiter=',') - -oncoMap = dict(); -MapOncokb(oncoMap) -with open('/home/soumya/cellworks/oncoKB_tmp.csv', 'rb') as csvFd: - reader = csv.reader(csvFd, delimiter='\t') - for row in reader: - lin = WriteDB(dbFd, oncoMap, row) - writer.writerow(lin) -civicMap = dict() -MapCivic(civicMap) -with open('/home/soumya/cellworks/civic_tmp.csv', 'rb') as csvFd: - reader = csv.reader(csvFd, delimiter='\t') - for row in reader: - lin = WriteDB(dbFd, civicMap, row) - writer.writerow(lin) - -synapseMap = dict() -MapSynapse(synapseMap) -with open('/home/soumya/cellworks/synapse_tmp.csv', 'rb') as csvFd: - reader = csv.reader(csvFd, delimiter=',') - for row in reader: - lin = WriteDB(dbFd, synapseMap, row) - writer.writerow(lin) - - - -#Store final data in mysql database. - -database = MySQLdb.connect(host='localhost', user='root', passwd='root') -cursor = database.cursor() -create_database = "CREATE DATABASE IF NOT EXISTS cellworks" -cursor.execute(create_database) -database = MySQLdb.connect(host='localhost', user='root', passwd='root', db='cellworks') -cursor = database.cursor() -create_table = "CREATE TABLE IF NOT EXISTS final_data (Data VARCHAR(255), Mutation VARCHAR(255), Signature VARCHAR(255), Varient VARCHAR(255), Functionality VARCHAR(255), Impact VARCHAR(255), Indication VARCHAR(255), Domain VARCHAR(255), Classification VARCHAR(255), Refrence VARCHAR(255))" -cursor.execute(create_table) -file = open('final_record.csv', "rb") -reader = csv.reader(file) -for row in reader: - cursor.execute('INSERT INTO final_data (Data,Mutation,Signature,Varient,Functionality,Impact,Indication,Domain,Classification,Refrence) VALUES("%s","%s","%s","%s","%s","%s","%s","%s","%s","%s")', (row[0], row[1], row[2], row[3], row[4], row[5], row[6], row[7], row[8], row[9])) - #print row -database.commit() -cursor.close() diff --git a/oncoKB_tmp.csv b/oncoKB_tmp.csv old mode 100644 new mode 100755 index 174b2af..9924720 --- a/oncoKB_tmp.csv +++ b/oncoKB_tmp.csv @@ -1,3702 +1,3701 @@ -Gene Alteration Oncogenicity Mutation Effect PMIDs for Mutation Effect Abstracts for Mutation Effect -FAM58A Truncating Mutations Likely Oncogenic Likely Loss-of-function 24218572, 18297069 -CBL H94Y Inconclusive Inconclusive 20126411, 26676746 -CBL M374V Likely Neutral Likely Neutral 26676746 -CBL R420Q Oncogenic Loss-of-function 25178484, 17446348, 19387008, 19734451 -CBL V391I Likely Oncogenic Loss-of-function 26676746 -CBL Deletion Likely Oncogenic Likely Loss-of-function 19276253, 19901108, 22315494 -CBL W802* Likely Oncogenic Likely Gain-of-function 20126411 -CBL Y371H Oncogenic Loss-of-function 23696637, 26676746 -CBL V430M Likely Neutral Likely Neutral 26676746 -CBL H398Y Likely Oncogenic Loss-of-function 19387008 -CBL Y371S Oncogenic Loss-of-function 19620960 -CBL K382E Likely Oncogenic Loss-of-function 25178484, 26676746 -CBL Truncating Mutations Likely Oncogenic Likely Loss-of-function 20508043, 20694012, 22315494 -CBL S376F Likely Oncogenic Loss-of-function 19387008 -CBL P417A Likely Oncogenic Loss-of-function 19387008 -CBL P428L Likely Neutral Likely Neutral 26676746 -CBL C381A Likely Oncogenic Loss-of-function 25178484, 26676746 -CBL C396R Likely Oncogenic Loss-of-function 26676746 -CBL S80N Inconclusive Inconclusive 20126411, 26676746 -CBL G375P Likely Oncogenic Loss-of-function 26676746 -CBL P395A Likely Oncogenic Loss-of-function 26676746 -CBL H398Q Likely Oncogenic Loss-of-function 26676746 -CBL D390Y Likely Oncogenic Loss-of-function 25178484 -CBL L399V Likely Oncogenic Loss-of-function 26676746 -CBL C384R Oncogenic Loss-of-function 23696637 -CBL Q367P Oncogenic Loss-of-function 19620960 -CBL N454D Likely Neutral Neutral 19387008 -CBL Q249E Likely Oncogenic Likely Gain-of-function 20126411 -SHOC2 M173I Likely Oncogenic Loss-of-function 25137548 -SHOC2 S2G Likely Oncogenic Loss-of-function 19684605, 23918763 -TERT H412Y Likely Oncogenic Loss-of-function 18042801 -TERT Promoter Mutations Oncogenic Gain-of-function 23348506, 23348503, 23887589, 24657534, 25048572, 23530248 -TERT P704S Likely Oncogenic Loss-of-function 18042801 -TERT Y846C Likely Oncogenic Loss-of-function 18042801 -TERT C250T Oncogenic Gain-of-function 23348506, 23348503, 23887589, 26389665, 24657534, 23530248 -TERT Amplification Likely Oncogenic Likely Gain-of-function 25219713, 18482052, 25301727 -TERT H876Q Likely Oncogenic Loss-of-function 18042801 -TERT C228T Oncogenic Gain-of-function 23348506, 23348503, 23887589, 24657534, 23530248 -DICER1 E1705K Likely Oncogenic Loss-of-function 22187960 -DICER1 E1705A Likely Oncogenic Loss-of-function 17920623 -DICER1 D1709N Oncogenic Loss-of-function 26033159, 22187960 -DICER1 D1709A Likely Oncogenic Likely Loss-of-function 22187960 -DICER1 Truncating Mutations Likely Oncogenic Likely Loss-of-function 20305640, 22133720, 21501861, 22353998, 21266384 -DICER1 D1709E Likely Oncogenic Likely Loss-of-function 22187960 -DICER1 D1810A Likely Oncogenic Loss-of-function 17920623 -DICER1 G1809K Likely Oncogenic Loss-of-function 26033159 -DICER1 G1809R Oncogenic Loss-of-function 26033159 -DICER1 Deletion Likely Oncogenic Likely Loss-of-function 20305640, 26513514, 27295554, 19903759, 22353998 -PTPRT T844M Likely Oncogenic Loss-of-function 24493670 -PTPRT A1022E Oncogenic Loss-of-function 24395800 -PTPRT R1343L Likely Oncogenic Loss-of-function 15155950 -PTPRT A707T Likely Oncogenic Likely Loss-of-function 20230342 -PTPRT Q984K Likely Oncogenic Loss-of-function 15155950, 22389709 -PTPRT N1125I Likely Oncogenic Loss-of-function 15155950, 22389709 -PTPRT Y412F Likely Oncogenic Likely Loss-of-function 20230342 -PTPRT Y280H Likely Oncogenic Likely Loss-of-function 18644975 -PTPRT L708P Likely Oncogenic Likely Loss-of-function 20230342 -PTPRT R1040L Oncogenic Likely Loss-of-function 24395800 -PTPRT A209T Likely Oncogenic Likely Loss-of-function 18644975 -PTPRT F74S Likely Oncogenic Likely Loss-of-function 15155950, 18644975 -PTPRT V648G Likely Oncogenic Likely Loss-of-function 20230342 -PTPRT R453C Likely Oncogenic Likely Loss-of-function 20230342 -PTPRT Promoter Hypermethylation Oncogenic Loss-of-function 25009298, 25982282, 23096495 -PTPRT Q479E Likely Oncogenic Likely Loss-of-function 20230342 -PTPRT S492F Likely Oncogenic Likely Loss-of-function 20230342 -PTPRT T1365M Likely Oncogenic Loss-of-function 15155950 -PTPRT F248S Likely Oncogenic Likely Loss-of-function 18644975 -PTPRT N510K Likely Oncogenic Likely Loss-of-function 20230342 -PTPRT V995M Likely Oncogenic Loss-of-function 24317090, 17360477 -PTPRT Truncating Mutations Likely Oncogenic Likely Loss-of-function 15155950, 20133777, 21517784 -PTPRT K218T Likely Oncogenic Likely Loss-of-function 18644975 -PTPRT T605M Likely Oncogenic Likely Loss-of-function 20230342 -PTPRT R1209W Likely Oncogenic Loss-of-function 15155950 -PTPRT D927G Likely Oncogenic Loss-of-function 22389709 -RHEB Y35H Likely Oncogenic Gain-of-function 24631838, 22819219 -RHEB Y35C Oncogenic Gain-of-function 24631838, 22819219 -RHEB Y35N Oncogenic Gain-of-function 24631838, 27399332, 22819219, 26255626 -SHQ1 Deletion Likely Oncogenic Likely Loss-of-function 19383767, 19019820, 20579941 -SHQ1 Truncating Mutations Likely Oncogenic Likely Loss-of-function -CCND2 Amplification Likely Oncogenic Likely Gain-of-function 8114739 -RAD50 L234fs Likely Oncogenic Likely Loss-of-function 16474176, 14684699, 16385572 -RAD50 Deletion Likely Oncogenic Likely Loss-of-function 12208847, 2659437, 14684699, 15309560 -RAD50 L1273F Likely Oncogenic Loss-of-function 24934408 -RAD50 Truncating Mutations Likely Oncogenic Likely Loss-of-function 12208847, 16288216, 21892167, 14684699 -CCND3 Amplification Likely Oncogenic Likely Gain-of-function 8114739 -CCND3 D286_L292trunc Likely Oncogenic Likely Gain-of-function 9832503 -CCND3 I290R Likely Oncogenic Likely Gain-of-function 2876518, 24913233, 22885699 -CCND3 T283A Likely Oncogenic Gain-of-function 2876518, 24913233, 22885699 -CCND3 T286A Likely Oncogenic Gain-of-function 9832503 -CCND3 I290A Likely Oncogenic Likely Gain-of-function 9832503 -CCND3 P284L Likely Oncogenic Likely Gain-of-function 2876518, 24913233, 22885699 -CCND3 Q276* Likely Oncogenic Gain-of-function 2876518, 24913233, 22885699 -RIT1 A77P Oncogenic Gain-of-function 24469055 -RIT1 A77T Likely Oncogenic Likely Gain-of-function 26714497 -RIT1 M90I Oncogenic Gain-of-function 24469055 -RIT1 A77S Oncogenic Gain-of-function 24469055 -CCNE1 Amplification Oncogenic Gain-of-function 8618861, 15838514, 12845634, 24605326 -CCNE1 Overexpression Oncogenic Gain-of-function 8618861, 15838514, 12845634, 24605326 -RYBP Truncating Mutations Likely Oncogenic Likely Loss-of-function 19098711 -TGFBR1 C41Y Likely Oncogenic Loss-of-function 21358634 -TGFBR1 N45S Likely Oncogenic Loss-of-function 21358634, 23358096 -TGFBR1 R487Q Likely Oncogenic Likely Loss-of-function 16928994, 25116393, 16791849 -TGFBR1 S241L Likely Oncogenic Likely Loss-of-function 16791849 -TGFBR1 G52R Likely Oncogenic Loss-of-function 21358634, 23358096 -TGFBR1 Truncating Mutations Likely Oncogenic Likely Loss-of-function 10656986, 11212236 -TGFBR1 S387Y Likely Oncogenic Loss-of-function 9809982 -TGFBR1 P83L Likely Oncogenic Loss-of-function 21358634 -TGFBR1 TGFBR1*6A Likely Oncogenic Loss-of-function 17848956, 10582683, 20429896, 16204663, 19882361, 22905183 -TGFBR2 R537P Likely Oncogenic Likely Gain-of-function 18339844 -TGFBR2 P525L Likely Oncogenic Loss-of-function 7862150 -TGFBR2 D404G Likely Oncogenic Loss-of-function 8668164 -TGFBR2 Deletion Likely Oncogenic Likely Loss-of-function 27558455, 25521327, 25736321 -TGFBR2 E526Q Likely Oncogenic Loss-of-function 18339844, 10789724 -TGFBR2 Truncating Mutations Likely Oncogenic Likely Loss-of-function 16310402, 17456004, 17985359, 9927040, 11309634, 7585632 -MSH6 T1219I Likely Oncogenic Likely Loss-of-function 11709755, 24362816, 22102614, 23621914 -MSH6 S144I Likely Neutral Likely Neutral 21120944 -MSH6 R1076C Likely Oncogenic Likely Loss-of-function 21056691, 19072991 -MSH6 Deletion Likely Oncogenic Likely Loss-of-function 25255306, 24090359, 21970482, 12019211, 22781090 -MSH6 F1088Sfs*2 Oncogenic Loss-of-function 9808525, 11474654, 19254532, 9331106 -MSH6 R1095H Likely Neutral Likely Neutral 22581703, 24040339, 12522549, 23621914 -MSH6 F1088Lfs*5 Oncogenic Loss-of-function 12732731, 11474654, 10959092, 9510473, 19254532, 21637783 -MSH6 Truncating Mutations Likely Oncogenic Likely Loss-of-function 9822680, 9111312, 1651234, 9564049 -MSH6 R976H Likely Oncogenic Likely Loss-of-function 11709755, 24362816, 11807791, 18790734 -MSH6 V509A Likely Neutral Likely Neutral 24362816 -MSH6 R922* Oncogenic Loss-of-function 24362816, 19254532 -MSH6 E946* Oncogenic Loss-of-function 12732731, 22810696, 19254532 -MSH6 E1322* Oncogenic Loss-of-function 24755471, 22810696, 19254532 -MSH6 G39E Likely Neutral Likely Neutral 24362816 -KMT2D Deletion Likely Oncogenic Likely Loss-of-function 24633898, 24240169, 26366712 -KMT2D Truncating Mutations Likely Oncogenic Likely Loss-of-function 24633898, 24240169, 26366712 -LATS1 Truncating Mutations Likely Oncogenic Loss-of-function 9988269, 23230145, 11850843 -LATS1 Deletion Likely Oncogenic Likely Loss-of-function 9988269, 23573293, 26040669 -PBRM1 Deletion Likely Oncogenic Likely Loss-of-function 18339845, 21248752, 23867514, 22949125 -PBRM1 N1333Gfs* Oncogenic Loss-of-function 25911086 -PBRM1 Truncating Mutations Likely Oncogenic Likely Loss-of-function 18339845, 24613357, 21248752, 22949125, 21654818 -SF3B1 H662D Likely Oncogenic Switch-of-function 25428262 -SF3B1 R625D Likely Oncogenic Switch-of-function 24434863 -SF3B1 G742D Likely Oncogenic Switch-of-function 24434863, 25428262, 21909114 -SF3B1 R625G Likely Oncogenic Switch-of-function 25788694, 26565915 -SF3B1 K666M Likely Oncogenic Switch-of-function 24434863 -SF3B1 R625C Likely Oncogenic Switch-of-function 24434863, 26565915, 23861464 -SF3B1 K666R Oncogenic Switch-of-function 25428262, 21909114 -SF3B1 R957Q Likely Oncogenic Switch-of-function 23160465 -SF3B1 K700R Likely Oncogenic Likely Switch-of-function 24434863, 26565915, 26619011, 25428262 -SF3B1 R625H Likely Oncogenic Switch-of-function 24434863, 26565915, 23861464 -SF3B1 H662Q Likely Oncogenic Switch-of-function 25428262, 21909114 -SF3B1 R625L Likely Oncogenic Switch-of-function 24434863, 26565915, 23861464 -SF3B1 K700E Likely Oncogenic Switch-of-function 25424858, 24434863, 26565915, 24854990, 23335386, 25428262, 23160465, 27622333, 21909114 -SF3B1 E622Q Likely Oncogenic Switch-of-function 26565915, 25428262, 21909114 -SF3B1 K666N Likely Oncogenic Switch-of-function 24434863, 25788694 -SF3B1 H662R Likely Oncogenic Switch-of-function 25428262, 21909114 -SF3B1 E622D Likely Oncogenic Switch-of-function 25428262, 21909114 -SF3B1 K666T Likely Oncogenic Switch-of-function 24434863, 26842708 -LATS2 Deletion Oncogenic Loss-of-function 21245096 -EGFR V769_D770insGVV Oncogenic Gain-of-function 23371856, 19536777, 24353160, 21764376, 18676761, 15897572, 17686547, 17192902 -EGFR L703P Likely Oncogenic Likely Gain-of-function 19020901 -EGFR S720P Likely Oncogenic Likely Gain-of-function 22760226, 15897572 -EGFR S784F Likely Oncogenic Gain-of-function 20522446, 21531810, 19147750, 21841502 -EGFR Exon 19 insertion Oncogenic Gain-of-function 21422421, 22190593 -EGFR L858Q Likely Oncogenic Likely Gain-of-function 24743239 -EGFR Exon 19 deletion Oncogenic Gain-of-function 15329413, 18000506, 15118125, 19536777, 18458038, 15118073, 22019513, 23566546, 23559152, 24457318, 22760226, 23749122, 17192902 -EGFR D770_N771insVDSVDNP Oncogenic Gain-of-function 23371856, 19536777, 24353160, 21764376, 18676761, 15897572, 21841502, 17686547 -EGFR K745_A750del Oncogenic Gain-of-function 15118073, 15329413, 25179728, 15118125 -EGFR T710A Likely Oncogenic Likely Gain-of-function 23912954 -EGFR H773dup Oncogenic Gain-of-function 24353160 -EGFR G863S Likely Oncogenic Likely Gain-of-function 18000506 -EGFR Y727H Likely Oncogenic Likely Gain-of-function 18000506 -EGFR E884K Oncogenic Gain-of-function 16407879, 19015641 -EGFR T790M Oncogenic Gain-of-function 15728811, 18227510, 15737014 -EGFR G796S Likely Oncogenic Gain-of-function 18193092 -EGFR L747V Likely Oncogenic Likely Gain-of-function 23242437, 22190593 -EGFR H773L Oncogenic Gain-of-function 17974985 -EGFR R841K Likely Neutral Likely Loss-of-function 18193092 -EGFR E746V Likely Oncogenic Likely Gain-of-function 16467085, 18000506 -EGFR S768_D770dup Oncogenic Gain-of-function 23371856, 19536777, 24353160, 21764376, 18676761, 23749122, 15897572, 17686547 -EGFR H870R Likely Neutral Likely Neutral 19671738, 21841502 -EGFR P691S Likely Oncogenic Likely Gain-of-function 22483783, 18000506 -EGFR L858M Likely Oncogenic Likely Gain-of-function 25232377 -EGFR R108K Oncogenic Gain-of-function 24120142, 17177598 -EGFR E746Q Likely Oncogenic Likely Gain-of-function 16467085 -EGFR L747_E749del Oncogenic Gain-of-function 16467085, 15118073, 15329413, 25179728, 15118125 -EGFR E709Q Likely Oncogenic Likely Gain-of-function 19671738, 15897572 -EGFR I744_K745delinsKIPVAI Oncogenic Gain-of-function 15118073, 15329413, 21841502, 15118125 -EGFR V726M Likely Oncogenic Likely Gain-of-function 18000506 -EGFR W731L Likely Oncogenic Gain-of-function 20942962 -EGFR A750_E758delinsP Oncogenic Gain-of-function 15118073, 15329413, 18261621, 15118125 -EGFR S464L Likely Oncogenic Likely Gain-of-function 25633215 -EGFR V774M Likely Oncogenic Likely Gain-of-function 21531810 -EGFR S921R Likely Neutral Inconclusive 19020901 -EGFR A763_Y764insFQEA Oncogenic Gain-of-function 24353160 -EGFR P753S Likely Oncogenic Likely Gain-of-function 16467085, 16106023, 25130612, 24934779 -EGFR N826Y Likely Oncogenic Likely Gain-of-function 21531810, 19147750 -EGFR S752_I759del Likely Oncogenic Likely Gain-of-function 23371856, 19536777, 24353160, 21764376, 18676761, 15897572, 17686547, 17192902 -EGFR E746_S752delinsI Oncogenic Gain-of-function 15118073, 15329413, 15118125, 17192902 -EGFR E709V Likely Oncogenic Likely Gain-of-function 21531810, 19536777, 26051236 -EGFR G465E Likely Oncogenic Likely Gain-of-function 26416732 -EGFR L861F Likely Oncogenic Likely Gain-of-function 21531810, 19536777, 19147750, 17177598, 26051236, 21252719 -EGFR S768I Oncogenic Gain-of-function 19536777, 16205628, 25521406, 25521405, 23242437, 19147750, 18676761, 23912954, 25179728, 25130612 -EGFR E709G Likely Oncogenic Likely Gain-of-function 21531810, 26051236, 23912954 -EGFR L747_T751del Oncogenic Gain-of-function 18325048, 23242437, 15118073, 15329413, 23387505, 15897572, 15118125 -EGFR E866K Likely Neutral Loss-of-function 19147750 -EGFR L747_S752del Oncogenic Gain-of-function 16467085, 15118073, 15329413, 15118125, 17192902 -EGFR G719S Oncogenic Gain-of-function 21531810, 16187797, 26206867 -EGFR A767_V769dup Oncogenic Gain-of-function 23371856, 19536777, 24353160, 21764376, 18676761, 23912954, 23749122, 15897572, 17686547 -EGFR L861P Likely Oncogenic Likely Gain-of-function 21531810, 17177598, 18000506 -EGFR L858R Oncogenic Gain-of-function 15118073, 15329413, 15118125 -EGFR L838P Likely Oncogenic Likely Gain-of-function 21531810 -EGFR L747P Oncogenic Gain-of-function 21531810, 18508816, 19536777, 26339441, 26001153, 22190593 -EGFR Fusions Likely Oncogenic Likely Gain-of-function 27102076, 23917401 -EGFR D761N Likely Oncogenic Gain-of-function 19147750, 26870223 -EGFR K467T Likely Oncogenic Likely Gain-of-function 25633215 -EGFR G465R Likely Oncogenic Likely Gain-of-function 26416732 -EGFR T785A Likely Oncogenic Gain-of-function 20942962 -EGFR E746_S752delinsV Oncogenic Gain-of-function 15118073, 15329413, 22483783, 25179728, 15710947, 15118125 -EGFR E330K Oncogenic Gain-of-function 24212795 -EGFR E734Q Likely Oncogenic Gain-of-function 20942962 -EGFR T725M Likely Oncogenic Gain-of-function 24743239 -EGFR D761Y Likely Oncogenic Likely Gain-of-function 17973572, 17545553, 19632948, 17085664, 17192902 -EGFR EGFRvV Oncogenic Gain-of-function 17189397, 1730638, 2790960 -EGFR EGFRvIII Oncogenic Gain-of-function 8895767, 17189397, 19324552, 8052651, 23777544, 12438278 -EGFR L861Q Oncogenic Gain-of-function 21531810, 18508816, 16467085, 17177598, 25668120, 21841502, 15897572, 21252719, 19536777, 18325048, 19147750, 26051236, 18676761, 23912954, 24457318, 22760226, 20808254, 23749122, 24285021 -EGFR P772_V774dup Oncogenic Gain-of-function 23371856, 19536777, 24353160, 21764376, 18676761, 25179728, 15897572, 17686547 -EGFR G719C Likely Oncogenic Likely Gain-of-function 21531810, 15118073, 19147750, 18261621, 26206867, 21841502 -EGFR A767_V769del Likely Oncogenic Likely Gain-of-function 23371856, 19536777, 24353160, 21764376, 18676761, 15897572, 17686547 -EGFR E746G Likely Oncogenic Likely Gain-of-function 21531810 -EGFR T34_A289del Oncogenic Gain-of-function 27216155 -EGFR G735S Oncogenic Gain-of-function 18193092, 25435280 -EGFR S768_V769insVAS Oncogenic Gain-of-function 23371856, 19536777, 24353160, 21764376, 18676761, 15897572, 21841502, 17686547 -EGFR H773insLGNP Oncogenic Gain-of-function 23371856, 19536777, 24353160, 21764376, 18676761, 23749122, 15897572, 17686547 -EGFR EGFRvII Oncogenic Gain-of-function 24893890, 17189397 -EGFR G810S Likely Oncogenic Gain-of-function 19147750 -EGFR L861R Oncogenic Gain-of-function 21531810, 17177598, 24743239, 21841502, 21252719 -EGFR R776H Likely Oncogenic Gain-of-function 23242437, 20512075, 23358982 -EGFR E746_S752delinsA Oncogenic Gain-of-function 15118073, 15329413, 15710947, 15118125 -EGFR E746_A750del Oncogenic Gain-of-function 18508816, 18325048, 16467085, 15118073, 15329413, 18261621, 22483783, 25179728, 16373402, 15710947, 15897572, 15118125 -EGFR T263P Oncogenic Gain-of-function 17177598 -EGFR G724S Oncogenic Gain-of-function 16166444, 24894453, 24743239 -EGFR S645C Likely Oncogenic Likely Gain-of-function 27478040 -EGFR H773Y Likely Oncogenic Likely Gain-of-function 19536777, 17974985, 18676761 -EGFR V843I Likely Oncogenic Gain-of-function 23380224, 21172876, 19536777, 25057940, 18000506, 18355544 -EGFR V774A Likely Oncogenic Likely Gain-of-function 21531810 -EGFR G863D Likely Oncogenic Gain-of-function 17376509, 16204011, 15897572 -EGFR S492R Likely Oncogenic Likely Switch-of-function 22270724 -EGFR Exon 19 deletion/insertion Oncogenic Gain-of-function 15329413, 18000506, 15118125, 19536777, 18458038, 15118073, 22019513, 23566546, 23559152, 24457318, 22760226, 23749122, 17192902 -EGFR C620Y Oncogenic Gain-of-function 24747966 -EGFR G857E Likely Oncogenic Likely Gain-of-function 23139256, 18000506, 19238633, 25435280 -EGFR P772_H773insYNP Oncogenic Gain-of-function 23371856, 19536777, 24353160, 21764376, 18676761, 15897572, 17686547 -EGFR A289V Oncogenic Gain-of-function 24120142, 17177598, 22588883 -EGFR D770_N771insSVD Oncogenic Gain-of-function 23371856, 19536777, 24353160, 21764376, 18676761, 15897572, 17686547 -EGFR E746_T751insIP Oncogenic Gain-of-function 18325048, 22190593 -EGFR EGFR-RAD51 Fusion Oncogenic Gain-of-function 27102076 -EGFR V742A Likely Oncogenic Gain-of-function 21531810, 23605641, 19147750, 16152581 -EGFR A864T Oncogenic Gain-of-function 23585556, 19147750, 21761100, 22722798, 16551849 -EGFR I941R Likely Neutral Likely Loss-of-function 24063894 -EGFR EGFR-KDD Oncogenic Gain-of-function 26286086 -EGFR E758G Likely Oncogenic Likely Gain-of-function 19536777 -EGFR V769M Likely Oncogenic Likely Gain-of-function 21531810, 23749122 -EGFR L704N Likely Neutral Loss-of-function 24063894 -EGFR L747S Likely Oncogenic Likely Gain-of-function 17973572, 18309959, 18645621, 19632948, 18981003 -EGFR R776C Likely Oncogenic Gain-of-function 19147750 -EGFR E746_T751delinsL Oncogenic Gain-of-function 15118073, 15329413, 18261621, 15118125 -EGFR K745M Likely Neutral Loss-of-function 21081186 -EGFR I853T Likely Neutral Loss-of-function 19147750 -EGFR P848L Likely Neutral Likely Neutral 23897956, 22848293, 25176975, 23912954, 17877814 -EGFR L747_P753del Oncogenic Gain-of-function 15118073, 15329413, 25179728, 15118125 -EGFR D770_N771insNPG Oncogenic Gain-of-function 23371856, 19536777, 24353160, 21764376, 18676761, 15897572, 17686547 -EGFR I491M Likely Oncogenic Likely Neutral 25633215 -EGFR N826S Oncogenic Gain-of-function 19147750, 15897572 -EGFR E709_T710delinsD Oncogenic Gain-of-function 21531810, 26206867 -EGFR V769_D770insASV Oncogenic Gain-of-function 23371856, 19536777, 24353160, 21764376, 18676761, 15897572, 17686547 -EGFR EGFR-PURB Fusion Likely Oncogenic Likely Gain-of-function 27102076 -EGFR L692F Likely Oncogenic Likely Gain-of-function 23912954 -EGFR E746_A750delinsQ Oncogenic Gain-of-function 15118073, 15329413, 15118125, 17192902 -EGFR G719A Oncogenic Gain-of-function 21531810, 26206867 -EGFR L747_A750del Oncogenic Gain-of-function 16467085, 15118073, 15329413, 15118125 -EGFR L838V Likely Oncogenic Gain-of-function 19147750 -EGFR E709A Likely Oncogenic Gain-of-function 21531810, 19671738, 23242437, 18261621, 23566546, 22483783, 23749122, 20479403, 15710947, 18372921, 21841502 -EGFR Exon 20 insertion Oncogenic Gain-of-function 23371856, 19536777, 24353160, 21764376, 18676761, 15897572, 17686547 -EGFR E868G Likely Oncogenic Gain-of-function 20942962, 16870303 -EGFR E746_T751delinsVA Oncogenic Gain-of-function 18508816, 15118073, 15329413, 15897572, 15118125 -EGFR E804G Likely Oncogenic Gain-of-function 18193092 -EGFR K806A Likely Oncogenic Likely Gain-of-function 19536777 -EGFR H773_V774insH Oncogenic Gain-of-function 24353160 -EGFR Y801H Likely Oncogenic Gain-of-function 20942962, 17224267 -EGFR D837N Likely Oncogenic Likely Gain-of-function 23749122 -EGFR D587H Likely Oncogenic Gain-of-function 26571394, 27245685 -EGFR N771_H773dup Oncogenic Gain-of-function 23371856, 19536777, 24353160, 21764376, 18676761, 23912954, 15897572, 17686547 -EGFR E746_T751delinsA Oncogenic Gain-of-function 15118073, 15329413, 15710947, 15897572, 15118125 -EGFR R836C Likely Oncogenic Likely Gain-of-function 23912954 -EGFR G598V Oncogenic Gain-of-function 24120142, 17177598, 22588883 -EGFR R324L Oncogenic Gain-of-function 24212795 -EGFR A750_E758del Oncogenic Gain-of-function 18325048, 15118073, 15329413, 15118125 -EGFR D770_N771insD Oncogenic Gain-of-function 23371856, 19536777, 24353160, 21764376, 18676761, 15897572, 17686547 -EGFR L747F Likely Oncogenic Likely Gain-of-function 16533793, 26773740, 24385129, 23485129, 26096169, 22190593 -EGFR L747_P753delinsS Oncogenic Gain-of-function 18508816, 15118073, 15329413, 19147750, 25179728, 15710947, 15897572, 15118125 -EGFR Amplification Oncogenic Gain-of-function 24120142, 10728703 -EGFR A859_L883delinsV Likely Oncogenic Likely Gain-of-function 18325048 -EGFR A750P Oncogenic Gain-of-function 19625781, 25179728, 15737014, 16187797 -EGFR E709K Oncogenic Gain-of-function 19726454, 23566546, 18000506, 25179728, 25130612, 23749122, 15710947, 26206867 -EGFR C797Y Likely Oncogenic Gain-of-function 20942962 -EGFR V765A Likely Oncogenic Likely Gain-of-function 15897572 -EGFR P596L Likely Oncogenic Likely Gain-of-function 17177598, 23243055 -EGFR G719D Likely Oncogenic Likely Gain-of-function 21531810, 18000506, 26206867 -EGFR L747_T751delinsP Oncogenic Gain-of-function 15118073, 15329413, 15710947, 15118125 -EGFR T783A Likely Oncogenic Likely Gain-of-function 18676761, 15897572 -EGFR L833V Oncogenic Gain-of-function 16205628, 21949883, 23912954, 25130612, 20808254, 21422421 -EGFR EGFRvIV Oncogenic Gain-of-function 20676128, 23007009 -EGFR D770_P772dup Oncogenic Gain-of-function 23371856, 19536777, 24353160, 21764376, 18676761, 23749122, 15897572, 17686547 -EGFR C628Y Likely Neutral Neutral 24747966 -EGFR L747_A750delinsP Oncogenic Gain-of-function 18508816, 15118073, 15329413, 15118125, 17192902 -EGFR V851A Likely Neutral Loss-of-function 19147750 -NKX2-1 Amplification Oncogenic Gain-of-function 17925434, 18212743, 22439932 -NKX2-1 Fusions Likely Oncogenic Likely Gain-of-function 21481790 -NKX2-1 A339V Likely Oncogenic Gain-of-function 19176457 -NKX2-1 TRB-NKX2-1 Fusion Likely Oncogenic Likely Gain-of-function 21481790 -NKX2-1 IGH-NKX2 Fusion Likely Oncogenic Likely Gain-of-function 21481790 -NKX2-1 TRA-NKX2-1 Fusion Likely Oncogenic Likely Gain-of-function 21481790 -EIF1AX A113_splice Oncogenic Gain-of-function 26878173 Krishnamoorthy et al. Abstract# 892, AACR 2016 http://cancerres.aacrjournals.org/content/76/14_Supplement/892 -ARID2 Truncating Mutations Likely Oncogenic Likely Loss-of-function 23047306, 21822264, 15985610, 16847454 -ARID2 Deletion Likely Oncogenic Likely Loss-of-function 23047306, 22095441, 15985610, 16847454 -BRD4 BRD4-NUT Fusion Oncogenic Gain-of-function 23604113, 21447744, 25512383, 20676058, 17934517, 20871596 -BRD4 Fusions Oncogenic Likely Gain-of-function 12543779, 23128391, 25564152 -BRD4 Amplification Likely Oncogenic Gain-of-function 12192049, 19596781, 15456879 -HIST1H1C S102F Likely Oncogenic Likely Loss-of-function 24362818 -ERRFI1 Deletion Likely Oncogenic Likely Loss-of-function 16648858, 21113414 -ERRFI1 Truncating Mutations Likely Oncogenic Likely Loss-of-function -CHEK2 R117G Likely Oncogenic Loss-of-function 16835864, 16982735 -CHEK2 I157T Inconclusive Inconclusive 16816021, 11571648, 15239132, 11053450, 14612911, 15492928, 11298456, 12049740 -CHEK2 H371Y Likely Oncogenic Loss-of-function 21618645, 25884806 -CHEK2 E321K Likely Oncogenic Loss-of-function 16835864 -CHEK2 K373E Oncogenic Loss-of-function 27716909 -CHEK2 S428F Likely Oncogenic Likely Loss-of-function 16998506, 15649950 -CHEK2 P85L Likely Neutral Neutral 16998506, 15649950 -CHEK2 E161del Likely Oncogenic Loss-of-function 16982735 -PAK1 Amplification Oncogenic Gain-of-function 21482786, 22105362 -TMPRSS2 TMPRSS2-ERG Fusion Oncogenic Gain-of-function 7731694, 16213704, 17043636 -TMPRSS2 Fusions Likely Oncogenic Likely Gain-of-function 16254181, 18283340 -TMPRSS2 T75M Likely Neutral Neutral 11745466, 25040002 -TMPRSS2 TMPRSS2-ETV5 Fusion Likely Oncogenic Likely Gain-of-function 18172298 -TMPRSS2 TMPRSS2-ETV4 Fusion Likely Oncogenic Likely Gain-of-function 16585160 -TMPRSS2 M160V Likely Neutral Neutral 11745466, 25040002 -TMPRSS2 TMPRSS2-ETV1 Fusion Oncogenic Gain-of-function 18563191, 23512661 -H3F3A K28M Likely Oncogenic Likely Switch-of-function 21685365, 22286061 -H3F3A G35V Likely Oncogenic Likely Switch-of-function 21685365, 23079654, 22286061 -H3F3A G35R Likely Oncogenic Likely Switch-of-function 21685365, 23079654, 22286061 -ELF3 I279P Likely Oncogenic Likely Loss-of-function 17148437 -ELF3 Truncating Mutations Likely Oncogenic Likely Loss-of-function 14976186, 17148437 -ELF3 K320E Likely Neutral Likely Neutral 17148437 -ELF3 A312P Likely Oncogenic Likely Loss-of-function 17148437 -ELF3 S330A Likely Neutral Likely Neutral 17148437 -ELF3 S308A Likely Neutral Likely Neutral 17148437 -ELF3 R331P Likely Oncogenic Likely Loss-of-function 17148437 -ROS1 S1986F Likely Oncogenic Likely Gain-of-function 27401242 -ROS1 ROS1-CD74 Fusion Oncogenic Gain-of-function 22919003, 22215748, 18083107, 22327623 -ROS1 CEP85L-ROS1 Fusion Likely Oncogenic Likely Gain-of-function 25204415, 23637631 -ROS1 E1935G Likely Oncogenic Likely Gain-of-function 24218589 -ROS1 FIG-ROS1 Fusion Oncogenic Gain-of-function 12661006, 2827175 -ROS1 G2101A Likely Oncogenic Likely Gain-of-function 22235099, 25688157, 24675041 -ROS1 KDELR2-ROS1 Fusion Likely Oncogenic Likely Gain-of-function 22980976 -ROS1 G1971E Likely Oncogenic Likely Gain-of-function 24218589 -ROS1 D2033N Likely Oncogenic Likely Gain-of-function 26673800 -ROS1 L1951R Inconclusive Inconclusive 25351743 -ROS1 C2060G Likely Oncogenic Likely Gain-of-function 24218589 -ROS1 SLC34A2-ROS1 Fusion Oncogenic Gain-of-function 22919003, 22215748, 22327623 -ROS1 TPM3-ROS1 Fusion Oncogenic Gain-of-function 22327623 -ROS1 TFG-ROS1 Fusion Likely Oncogenic Likely Gain-of-function 24875859 -ROS1 S1986Y Likely Oncogenic Likely Gain-of-function 27401242 -ROS1 G2032R Likely Oncogenic Likely Gain-of-function 25351743, 24047073, 24047072, 23724914, 27401242, 25688157 -ROS1 Fusions Likely Oncogenic Likely Gain-of-function 22919003, 23719267, 22215748 -ROS1 CD74-ROS1 Fusion Oncogenic Gain-of-function 22919003, 22215748, 18083107, 22327623 -ROS1 YWHAE-ROS1 Fusion Likely Oncogenic Likely Gain-of-function 24875859 -ROS1 LIMA1-ROS1 Fusion Likely Oncogenic Likely Gain-of-function 25264305 -ROS1 MSN-ROS1 Fusion Likely Oncogenic Likely Gain-of-function 25264305 -ROS1 EZR-ROS1 Fusion Oncogenic Gain-of-function 22327623 -ROS1 LRIG3-ROS1 Fusion Oncogenic Gain-of-function 22327623 -ROS1 Amplification Likely Oncogenic Likely Gain-of-function 25978031 -ROS1 V2098I Likely Oncogenic Likely Gain-of-function 24218589 -ROS1 SDC4-ROS1 Fusion Oncogenic Gain-of-function 22327623 -ROS1 L1947R Likely Oncogenic Likely Gain-of-function 24218589 -ROS1 CCDC6-ROS1 Fusion Likely Oncogenic Likely Gain-of-function 22975805, 25870798 -ASXL2 Truncating Mutations Likely Oncogenic Likely Loss-of-function 24973361 Li et al. Abstract# 1509, ASH 2016 http://www.bloodjournal.org/content/128/22/1509 -ASXL2 Deletion Likely Oncogenic Likely Loss-of-function 24973361 Li et al. Abstract# 1509, ASH 2016 http://www.bloodjournal.org/content/128/22/1509 -CDH1 D257N Likely Oncogenic Likely Loss-of-function 24690483 -CDH1 R732Q Likely Oncogenic Likely Loss-of-function 15235021, 17545690 -CDH1 T340A Oncogenic Loss-of-function 12588804 -CDH1 Deletion Likely Oncogenic Likely Loss-of-function 23812922, 2070412, 23341533, 19168852, 9515965, 24037103 -CDH1 Epigenetic Silencing Likely Oncogenic Likely Loss-of-function 11313896, 7543680 -CDH1 A617T Likely Oncogenic Loss-of-function 12588804 -CDH1 A634V Oncogenic Loss-of-function 12588804 -CDH1 D254N Oncogenic Loss-of-function 26123647 -CDH1 Truncating Mutations Likely Oncogenic Likely Loss-of-function 8934538, 2070412, 9515965, 17522512 -CDH1 A298T Likely Oncogenic Likely Loss-of-function 24204729 -EPCAM 3' Deletion Oncogenic Loss-of-function 21145788 -TOP1 Truncating Mutations Likely Oncogenic Likely Loss-of-function -EP300 EP300-MLL Fusion Likely Oncogenic Gain-of-function 18778367, 23307074, 9389684, 20980053 -EP300 Deletion Likely Oncogenic Likely Loss-of-function 10700188, 12402157, 12237408 -EP300 Fusions Likely Oncogenic Likely Gain-of-function 25943178, 26293203, 23307074 -EP300 Truncating Mutations Likely Oncogenic Likely Loss-of-function 10700188, 15156177, 12402157, 12237408 -EP300 D1399Y Likely Oncogenic Loss-of-function 12586840, 25151357 -EP300 P1502L Likely Oncogenic Loss-of-function 25151357 -EP300 C1385 Likely Oncogenic Loss-of-function 18273021 -EP300 EP300-MOZ Fusion Likely Oncogenic Gain-of-function 10824998, 23307074, 11243405 -EP300 Y1414C Likely Oncogenic Loss-of-function 25151357 -EP300 R1627 Likely Oncogenic Loss-of-function 18273021 -EPAS1 P531A Likely Oncogenic Likely Gain-of-function 23054256, 14691554, 12086860 -EPAS1 533_534del Likely Oncogenic Likely Gain-of-function 22931260, 23418310 -EPAS1 Y532C Likely Oncogenic Likely Gain-of-function 23361906, 23653463 -EPAS1 A530V Likely Oncogenic Likely Gain-of-function 22931260, 23418310 -EPAS1 A530T Likely Oncogenic Likely Gain-of-function 22931260, 23418310 -EPAS1 P531S Likely Oncogenic Likely Gain-of-function 22931260, 23418310 -EPAS1 P531L Likely Oncogenic Likely Gain-of-function 22931260, 23418310 -EPAS1 534_536del Likely Oncogenic Likely Gain-of-function 22931260, 23418310 -TP53 H179Q Likely Oncogenic Loss-of-function 22540896 -TP53 I255F Likely Oncogenic Likely Loss-of-function 25408419 -TP53 R158C Likely Oncogenic Likely Loss-of-function 17947339 -TP53 H179R Likely Oncogenic Loss-of-function 17361096, 22427690 -TP53 C238F Likely Oncogenic Loss-of-function 20407015 -TP53 G334R Likely Neutral Neutral 25584008 -TP53 R282W Likely Oncogenic Likely Loss-of-function 21445056 -TP53 H168N Likely Oncogenic Likely Loss-of-function 19462533 -TP53 S215G Oncogenic Loss-of-function 17724467, 8023157, 26619011, 22862161, 11900253 -TP53 G266R Likely Oncogenic Loss-of-function 16827139 -TP53 P219S Likely Oncogenic Loss-of-function 10229196, 25584008 -TP53 F338I Likely Oncogenic Likely Loss-of-function 19454241, 20978130 -TP53 R110L Likely Oncogenic Likely Loss-of-function 21445056, 16778209 -TP53 Truncating Mutations Likely Oncogenic Likely Loss-of-function 19336573, 27759562, 16007150, 11753428, 11900253, 21467160 -TP53 P153H Likely Oncogenic Likely Loss-of-function 15781620, 8023157, 11900253 -TP53 Y236C Likely Oncogenic Loss-of-function 16827139 -TP53 Q331H Likely Oncogenic Likely Loss-of-function 26619011, 20978130 -TP53 L330H Likely Oncogenic Likely Loss-of-function 19454241, 20978130 -TP53 L348F Likely Oncogenic Likely Loss-of-function 19454241 -TP53 V197E Likely Oncogenic Likely Loss-of-function 25408419 -TP53 R248L Likely Oncogenic Likely Loss-of-function 26748848, 25584008 -TP53 G244S Oncogenic Loss-of-function 26818906 -TP53 S121F Likely Oncogenic Likely Gain-of-function 15781620 -TP53 R283Q Likely Oncogenic Likely Loss-of-function 7651437 -TP53 C135S Likely Oncogenic Likely Loss-of-function 17914575, 8023157, 11900253 -TP53 K120E Oncogenic Loss-of-function 18524770, 24814347, 17189187 -TP53 R273G Likely Oncogenic Likely Loss-of-function 24677579, 26619011 -TP53 K120M Oncogenic Loss-of-function 17189187 -TP53 R248W Likely Oncogenic Loss-of-function 18762571, 10229196, 25584008 -TP53 H233N Likely Oncogenic Likely Loss-of-function 19462533, 26619011 -TP53 I251S Likely Oncogenic Likely Loss-of-function 26748848 -TP53 R290G Likely Oncogenic Likely Loss-of-function 15781620, 8023157, 26619011, 11900253 -TP53 R280K Oncogenic Loss-of-function 24714748 -TP53 R181H Likely Oncogenic Loss-of-function 20471942 -TP53 C277Q Likely Oncogenic Likely Loss-of-function 7651437 -TP53 H179L Oncogenic Loss-of-function 23150443 -TP53 G266E Likely Oncogenic Likely Loss-of-function 17724467 -TP53 G244R Oncogenic Loss-of-function 11160722 -TP53 Y234C Likely Oncogenic Loss-of-function 10229196, 26748848, 16861262 -TP53 T123A Likely Neutral Likely Neutral 16687402, 18996393 -TP53 K292T Likely Oncogenic Likely Loss-of-function 15781620, 8023157, 26619011, 11900253 -TP53 C176R Likely Oncogenic Loss-of-function 8633021 -TP53 S241F Likely Oncogenic Likely Loss-of-function 21383700 -TP53 F341C Likely Oncogenic Likely Loss-of-function 19454241, 20978130 -TP53 L145R Oncogenic Loss-of-function 8023157, 11900253 -TP53 R337L Likely Oncogenic Likely Loss-of-function 19454241, 20978130, 11481490 -TP53 R175C Likely Oncogenic Likely Loss-of-function 9632751, 26619011, 22955915 -TP53 C135R Likely Oncogenic Loss-of-function 17914575 -TP53 K120R Likely Oncogenic Loss-of-function 7651437, 17189187 -TP53 C238S Likely Oncogenic Loss-of-function 19681600 -TP53 I254T Oncogenic Loss-of-function 25584008 -TP53 S241T Likely Oncogenic Loss-of-function 11896595 -TP53 S121Y Inconclusive Inconclusive 15781620 -TP53 R175H Oncogenic Loss-of-function 15781620, 10713666, 21445056, 25584008, 22114072 -TP53 H179Y Likely Oncogenic Loss-of-function 17530187 -TP53 R248Q Likely Oncogenic Likely Loss-of-function 24814347, 21445056, 16778209 -TP53 R181L Likely Oncogenic Likely Loss-of-function 20471942 -TP53 H193N Likely Oncogenic Loss-of-function 19462533 -TP53 R213Q Likely Oncogenic Loss-of-function 10871862 -TP53 A347T Likely Oncogenic Likely Loss-of-function 19454241, 20978130 -TP53 R156C Likely Oncogenic Likely Loss-of-function 15781620, 8023157, 11900253 -TP53 P278A Likely Oncogenic Likely Loss-of-function 24076587 -TP53 N239S Oncogenic Loss-of-function 22553460 -TP53 V272M Likely Oncogenic Likely Loss-of-function 15037740, 11870884 -TP53 S121A Likely Neutral Likely Gain-of-function 15781620 -TP53 G356A Inconclusive Inconclusive 20978130 -TP53 H179N Likely Oncogenic Likely Loss-of-function 19462533 -TP53 P47S Likely Neutral Neutral 25584008 -TP53 R282Q Likely Oncogenic Likely Loss-of-function 18453682 -TP53 Y163C Likely Oncogenic Loss-of-function 8023157, 23246812, 15037740, 25584008, 11900253, 15077194 -TP53 S121C Inconclusive Inconclusive 15781620 -TP53 H214Q Likely Oncogenic Likely Loss-of-function 15781620, 26619011 -TP53 S240R Likely Oncogenic Likely Loss-of-function 10229196 -TP53 Y234H Likely Oncogenic Loss-of-function 22710932 -TP53 Y236S Likely Oncogenic Loss-of-function 11429705 -TP53 R337H Likely Oncogenic Likely Loss-of-function 19454241, 25584008, 11481490 -TP53 G245S Oncogenic Loss-of-function 2358418, 15037740 -TP53 P151H Likely Oncogenic Likely Loss-of-function 8023157, 22908277, 11900253 -TP53 R248K Likely Oncogenic Likely Loss-of-function 7651437 -TP53 K291E Likely Oncogenic Likely Loss-of-function 15781620, 8023157, 26619011, 11900253 -TP53 R273H Oncogenic Loss-of-function 26181206, 15037740, 25584008 -TP53 H214R Likely Oncogenic Likely Loss-of-function 20407015, 26619011 -TP53 Y236D Likely Oncogenic Loss-of-function 8633021 -TP53 Deletion Likely Oncogenic Likely Loss-of-function 26982726, 27759562, 19477430, 11900253, 12584563 -TP53 DNA binding domain deletions Oncogenic Loss-of-function 8023157, 11900253 -TP53 A161T Likely Oncogenic Likely Loss-of-function 21232794, 16827139 -TP53 P151S Oncogenic Loss-of-function 2857548 -TP53 S215C Likely Oncogenic Likely Loss-of-function 15781620, 26619011, 12917626 -TP53 H297N Likely Neutral Likely Neutral 19462533 -TP53 L344P Likely Oncogenic Loss-of-function 19454241, 20978130, 19106109 -TP53 Q331R Likely Oncogenic Likely Loss-of-function 20978130 -TP53 L330R Likely Oncogenic Likely Loss-of-function 19454241, 20978130 -TP53 R249S Likely Oncogenic Likely Loss-of-function 21445056, 18996393, 14741214 -TP53 K120A Likely Oncogenic Likely Loss-of-function 24814347, 16687402 -TP53 P316L Likely Oncogenic Likely Loss-of-function 10618702, 2553699, 20010306 -TP53 F212Y Inconclusive Inconclusive 15781620 -TP53 G199R Likely Oncogenic Likely Loss-of-function 10229196 -TP53 P250L Likely Oncogenic Likely Loss-of-function 21445056 -TP53 Y220C Oncogenic Loss-of-function 23315175, 15037740, 23630318 -TP53 DNA binding domain missense mutations Oncogenic Loss-of-function 8023157, 11900253 -TP53 G244D Likely Oncogenic Likely Loss-of-function 12901798 -TP53 C229R Likely Oncogenic Likely Loss-of-function 25584008 -TP53 C242Y Likely Oncogenic Loss-of-function 20407015 -TP53 V197L Likely Oncogenic Likely Loss-of-function 11668476 -TP53 R181C Likely Oncogenic Loss-of-function 10229196, 20471942 -TP53 G245D Likely Oncogenic Likely Loss-of-function 25119136, 22803791, 22214764 -TP53 R337C Likely Oncogenic Loss-of-function 19454241, 17311302, 16007150, 19106109, 11753428 -TP53 C242S Likely Oncogenic Loss-of-function 20407015 -TP53 C141Y Likely Oncogenic Likely Loss-of-function 15037740 -TP53 DNA binding domain insertions Oncogenic Loss-of-function 8023157, 11900253 -TP53 K292I Likely Oncogenic Likely Gain-of-function 15781620, 8023157, 11900253 -TP53 V173L Likely Oncogenic Loss-of-function 15037740 -TP53 Y220S Likely Oncogenic Loss-of-function 15977174 -TP53 H193R Likely Oncogenic Likely Loss-of-function 9627118 -TP53 R342P Likely Oncogenic Loss-of-function 19454241, 20978130 -TP53 C277W Likely Oncogenic Likely Loss-of-function 24814347 -TP53 F328V Likely Oncogenic Likely Loss-of-function 19454241 -TP53 V173E Likely Oncogenic Loss-of-function 9472631 -TP53 R156H Likely Oncogenic Loss-of-function 10435620 -TP53 R158H Likely Oncogenic Loss-of-function 10229196, 25584008 -TP53 R273L Likely Oncogenic Loss-of-function 8023157, 15037740, 11900253 -TP53 V274F Likely Oncogenic Likely Loss-of-function 12782597 -TP53 V157D Oncogenic Loss-of-function 23981578 -TP53 K291Q Likely Oncogenic Likely Loss-of-function 15781620, 8023157, 11900253 -TP53 S241Y Likely Oncogenic Loss-of-function 25584008 -TP53 E285K Likely Oncogenic Likely Loss-of-function 20407015 -TP53 P151A Likely Oncogenic Loss-of-function 20407015 -TP53 R280T Likely Oncogenic Likely Loss-of-function 22999923 -TP53 P278L Likely Oncogenic Loss-of-function 16861262 -TP53 E258V Likely Oncogenic Likely Loss-of-function 21445056 -TP53 E285V Oncogenic Loss-of-function 18762572, 25584008 -TP53 T329I Inconclusive Inconclusive 20978130 -TP53 L330P Likely Oncogenic Likely Loss-of-function 20978130 -TP53 M237K Likely Oncogenic Likely Loss-of-function 20505364 -TP53 R158L Likely Oncogenic Loss-of-function 15037740, 25584008, 16861262 -TP53 R290H Likely Oncogenic Likely Loss-of-function 10435620 -TP53 R273C Likely Oncogenic Likely Loss-of-function 15037740, 23863845, 11900253, 23612969 -TP53 E221Q Inconclusive Inconclusive 15781620 -TP53 H115N Inconclusive Inconclusive 19462533 -TP53 R249W Oncogenic Loss-of-function 23612969 -TP53 I162M Likely Oncogenic Likely Loss-of-function 15781620, 8023157, 11900253 -TP53 K120N Likely Oncogenic Loss-of-function 7651437 -TP53 V157F Likely Oncogenic Likely Loss-of-function 21561095, 15037740, 16778209 -TP53 R337P Likely Oncogenic Likely Loss-of-function 19454241, 20978130, 11481490 -TP53 Q144R Likely Oncogenic Likely Loss-of-function 15781620, 8023157, 26619011, 11900253 -TP53 H168R Likely Oncogenic Loss-of-function 18996393 -TP53 I195T Likely Oncogenic Likely Loss-of-function 8023157, 11900253, 12700230 -TP53 V143A Likely Oncogenic Likely Loss-of-function 10435620 -TP53 P278R Likely Oncogenic Loss-of-function 21760996 -TP53 C277R Likely Oncogenic Likely Loss-of-function 7651437 -TP53 R110P Likely Oncogenic Likely Loss-of-function 21445056 -TP53 P278S Likely Oncogenic Loss-of-function 22989750 -TP53 Q144P Likely Oncogenic Likely Loss-of-function 10229196 -TP53 E286K Likely Oncogenic Loss-of-function 15037740 -TP53 G245A Likely Oncogenic Likely Loss-of-function 20589832 -TP53 R249M Likely Oncogenic Loss-of-function 17999388, 15037740 -TP53 H193P Likely Oncogenic Loss-of-function 25584008 -TP53 M133T Likely Oncogenic Likely Loss-of-function 21311097 -TP53 R175L Likely Oncogenic Loss-of-function 15781620, 18762572, 25584008 -TP53 N235D Oncogenic Loss-of-function 25584008 -TP53 V272L Likely Oncogenic Likely Loss-of-function 20407015, 26619011 -TP53 R202S Likely Oncogenic Likely Loss-of-function 10229196 -TP53 T150I Likely Oncogenic Likely Loss-of-function 10229196 -TP53 R280A Likely Oncogenic Likely Loss-of-function 18524770, 24814347, 17189187 -TP53 A161S Likely Oncogenic Loss-of-function 25119136 -TP53 L344R Likely Oncogenic Likely Loss-of-function 19454241, 20978130 -TP53 D186A Likely Oncogenic Likely Loss-of-function 24814347 -TP53 E326L Likely Oncogenic Loss-of-function 26748848 -TP53 R267Q Likely Oncogenic Likely Loss-of-function 10435620, 25584008 -TP53 V218dup Oncogenic Loss-of-function 8023157, 11900253 -TP53 C275S Likely Oncogenic Loss-of-function 25584637 -TP53 L348S Likely Oncogenic Likely Loss-of-function 20978130 -TP53 C242F Likely Oncogenic Likely Loss-of-function 17401432 -TP53 C176F Likely Oncogenic Loss-of-function 22090360 -TP53 H214N Likely Oncogenic Likely Loss-of-function 19462533 -TP53 R267P Likely Oncogenic Likely Gain-of-function 23264849, 22989750 -TP53 C135Y Likely Oncogenic Switch-of-function 22847613 -TP53 G245C Likely Oncogenic Likely Loss-of-function 15037740, 22803791 -TP53 E180K Likely Oncogenic Loss-of-function 24814347, 20471942 -TP53 R273K Likely Oncogenic Loss-of-function 7651437 -TP53 F134Y Likely Oncogenic Likely Loss-of-function 26619011, 25584008 -TP53 P152L Likely Oncogenic Likely Loss-of-function 25584008 -TP53BP1 Truncating Mutations Likely Oncogenic Likely Loss-of-function 23103855 -TP53BP1 Deletion Likely Oncogenic Likely Loss-of-function 16260621, 22915756 -SMAD2 Deletion Likely Oncogenic Loss-of-function 15133179, 20010874, 16382155, 18618014, 12384562, 22204491, 19276350, 20852387 -SMAD2 F346V Likely Neutral Likely Neutral 11274206 -SMAD2 D450E Likely Oncogenic Likely Loss-of-function 23139211 -SMAD2 R310H Likely Oncogenic Likely Loss-of-function 11274206 -SMAD2 T413N Likely Oncogenic Likely Loss-of-function 23139211 -SMAD2 R428A Inconclusive Inconclusive 11779503 -SMAD2 N387P Inconclusive Inconclusive 11779503 -SMAD2 V319D Likely Oncogenic Likely Loss-of-function 11274206 -SMAD2 Y426A Likely Oncogenic Likely Loss-of-function 11779503, 9463378 -SMAD2 K375A Inconclusive Inconclusive 11779503 -SMAD2 S276L Likely Oncogenic Likely Loss-of-function 23139211 -SMAD2 S467P Likely Oncogenic Likely Loss-of-function 23139211 -SMAD2 K420A Likely Oncogenic Likely Loss-of-function 14729957, 11779503 -SMAD2 Y406H Inconclusive Inconclusive 11779503 -SMAD2 W368H Likely Neutral Likely Neutral 11274206, 11779503 -SMAD2 D300H Likely Oncogenic Likely Loss-of-function 11274206, 11779503 -SMAD2 D450H Likely Oncogenic Likely Loss-of-function 11779503 -SMAD2 R321Q Likely Oncogenic Loss-of-function 16828225, 20937913 -SMAD2 P305L Likely Oncogenic Likely Loss-of-function 23139211 -SMAD2 Truncating Mutations Likely Oncogenic Likely Loss-of-function 12894231, 23139211, 15711891, 11779503 -SMAD2 D300N Likely Oncogenic Likely Loss-of-function 23139211 -SMAD3 Truncating Mutations Likely Oncogenic Likely Loss-of-function 11691834 -SMAD3 Y297A Likely Oncogenic Likely Loss-of-function 21949838 -SMAD3 W406A Likely Oncogenic Likely Loss-of-function 21949838 -SMAD3 R292A Likely Oncogenic Likely Loss-of-function 21949838 -SMAD3 K341A Likely Oncogenic Likely Loss-of-function 21949838 -SMAD3 D258N Likely Oncogenic Loss-of-function 23139211 -SMAD3 D408H Likely Oncogenic Loss-of-function 21949838 -SMAD3 Y298A Likely Oncogenic Likely Loss-of-function 21949838 -SMAD3 R268A Likely Oncogenic Loss-of-function 21949838 -SMAD3 Y238A Likely Oncogenic Likely Loss-of-function 21949838 -SMAD3 D408Y Likely Oncogenic Loss-of-function 23139211 -SMAD3 P336S Likely Oncogenic Loss-of-function 23139211 -SMAD3 Deletion Likely Oncogenic Likely Loss-of-function 14647420, 18852474, 9753318, 16951153 -SMAD3 R373H Likely Oncogenic Likely Loss-of-function 16828225 -SMAD3 Y226A Likely Oncogenic Likely Loss-of-function 21949838 -SMAD3 Y237A Likely Neutral Neutral 17994767 -SMAD3 R373Q Likely Oncogenic Loss-of-function 23139211 -SMAD3 R287A Likely Oncogenic Loss-of-function 17994767 -SMAD3 D408E Likely Oncogenic Loss-of-function 10092624 -SMAD3 V356R Likely Oncogenic Likely Loss-of-function 21949838 -SMAD3 S425C Likely Oncogenic Loss-of-function 23139211 -SMAD3 Y384A Likely Oncogenic Likely Loss-of-function 21949838 -SMAD3 E239A Likely Oncogenic Loss-of-function 17994767 -SMAD3 V277D Likely Oncogenic Loss-of-function 10092624 -SMAD3 R243A Likely Oncogenic Likely Loss-of-function 21949838 -SMAD4 P130S Likely Oncogenic Loss-of-function 14647410 -SMAD4 E330A Likely Oncogenic Loss-of-function 17994767 -SMAD4 W398V Inconclusive Inconclusive 11274206 -SMAD4 L43V Likely Oncogenic Likely Loss-of-function 14647410 -SMAD4 C324Y Likely Oncogenic Likely Loss-of-function 22109972 -SMAD4 P102L Likely Oncogenic Likely Loss-of-function 14647410 -SMAD4 R441P Likely Neutral Likely Neutral 11274206, 11779503, 10822381 -SMAD4 Deletion Likely Oncogenic Loss-of-function 22321641, 25893305, 9482899, 10626800, 9506519, 17114584, 19841536, 10773876 -SMAD4 D493H Likely Oncogenic Loss-of-function 11274206, 19139564 -SMAD4 R378A Likely Oncogenic Likely Loss-of-function 15350224 -SMAD4 K507Q Likely Oncogenic Likely Loss-of-function 14647410 -SMAD4 Truncating Mutations Likely Oncogenic Likely Loss-of-function 23139211, 10340381, 15711891, 9094310, 11553622 -SMAD4 E330K Likely Oncogenic Loss-of-function 26488212 -SMAD4 R420H Likely Oncogenic Likely Neutral 11274206, 11779503 -SMAD4 R100T Likely Oncogenic Loss-of-function 14647410, 10092624 -SMAD4 R515A Likely Oncogenic Loss-of-function 11779503 -SMAD4 D357Y Likely Oncogenic Loss-of-function 14715079 -SMAD4 W509R Inconclusive Inconclusive 22316667 -SMAD4 K507A Likely Oncogenic Likely Loss-of-function 11779503 -SMAD4 R515G Likely Oncogenic Loss-of-function 14647410 -SMAD4 G419V Likely Oncogenic Loss-of-function 26488212 -SMAD4 D537E Likely Oncogenic Loss-of-function 9214508, 23139211, 14715079 -SMAD4 Y513A Inconclusive Inconclusive 11779503 -SMAD4 H132Y Likely Oncogenic Likely Loss-of-function 25275298 -SMAD4 E330G Likely Oncogenic Likely Loss-of-function 22316667 -SMAD4 R361C Likely Oncogenic Loss-of-function 9214508, 14647410, 26488212, 10092624 -SMAD4 K428A Likely Oncogenic Likely Loss-of-function 11779503 -SMAD4 D537Y Oncogenic Loss-of-function 23139211, 14715079 -SMAD4 V370D Likely Oncogenic Likely Loss-of-function 9214508, 11274206, 10092624, 19139564, 11779503 -SMAD4 R497H Likely Oncogenic Loss-of-function 14647410 -SMAD4 Y353L Likely Oncogenic Likely Loss-of-function 26619011 -SMAD4 D351H Likely Oncogenic Loss-of-function 9214508, 14647410, 11274206, 11779503, 14715079 -SMAD4 G508S Likely Oncogenic Likely Loss-of-function 9214508, 9153220 -SMAD4 D493A Likely Oncogenic Likely Loss-of-function 15350224 -SMAD4 R496H Likely Oncogenic Loss-of-function 26488212 -SMAD4 A532H Likely Oncogenic Loss-of-function 11274206 -SMAD4 V465M Inconclusive Inconclusive 22316667 -CDK4 R24C Oncogenic Gain-of-function 11606789, 11756559 -CDK4 Amplification Oncogenic Gain-of-function 20534551, 8101826, 10970848 -CDK4 K22A Oncogenic Gain-of-function 9426066, 9712735, 9228064 -AURKB Overexpression Likely Oncogenic Likely Gain-of-function 17344846, 26240282, 18347165, 16222316 -AURKB Amplification Likely Oncogenic Likely Gain-of-function 26240282 -CDK6 Amplification Oncogenic Gain-of-function 17989712, 23127611, 11940479, 20534551, 24736461, 22476749, 12900351, 19145199, 24764564 -CDK6 A197T Likely Neutral Loss-of-function 23918663 -FBXW7 G423R Likely Oncogenic Likely Loss-of-function 24838835, 26619011 -FBXW7 R505L Oncogenic Loss-of-function 17646409 -FBXW7 K11R Likely Oncogenic Likely Loss-of-function 20815813 -FBXW7 S462Y Likely Neutral Likely Neutral 27147599 -FBXW7 R465H Likely Oncogenic Loss-of-function 27147599, 24912918, 23228967, 17575125, 22608923 -FBXW7 D520N Likely Oncogenic Likely Loss-of-function 11565034, 19420964 -FBXW7 S562L Likely Neutral Neutral 24838835 -FBXW7 Truncating Mutations Likely Oncogenic Likely Loss-of-function 17646409, 15103331, 18094723 -FBXW7 R505C Oncogenic Loss-of-function 27147599, 17646408, 17575125, 23228967, 24838835, 22608923, 23095493 -FBXW7 S227A Likely Oncogenic Loss-of-function 21620836 -FBXW7 Deletion Likely Oncogenic Likely Loss-of-function 25314076, 27764699, 18367647, 15103331 -FBXW7 R479H Likely Oncogenic Loss-of-function 17575125 -FBXW7 R658Q Likely Oncogenic Likely Loss-of-function 27147599, 26619011 -FBXW7 I347M Likely Neutral Likely Neutral 27147599 -FBXW7 T205A Likely Neutral Likely Gain-of-function 22608923 -FBXW7 R465C Oncogenic Loss-of-function 17646408, 17909001, 17646409, 23095493 -FBXW7 R479Q Oncogenic Loss-of-function 17646408, 17909001, 23228967, 17646409 -FBXW7 R689Q Likely Oncogenic Likely Loss-of-function 27147599, 26619011 -FBXW7 R479L Likely Oncogenic Loss-of-function 24912918, 22608923 -FBXW7 R482Q Oncogenic Loss-of-function 23676439 -FBXW7 Copy Number Loss Oncogenic Loss-of-function 19739118, 24884509, 18367647, 18094723, 25555218, 22673505 -CDK8 Amplification Oncogenic Gain-of-function 18794900 -CDKN1A S31R Inconclusive Inconclusive 7655464, 20127253, 18046503, 17293864 -CDKN1A Truncating Mutations Likely Oncogenic Likely Loss-of-function 23159848, 24317508 -CDKN1A Deletion Likely Oncogenic Likely Loss-of-function 19106607, 25483104, 23624841, 15960923 -CDKN1B Deletion Oncogenic Loss-of-function 8646779, 23460367, 18073348, 21422114 -CDKN1B P133T Likely Oncogenic Likely Loss-of-function 21289244 -CDKN1B Truncating Mutations Likely Oncogenic Likely Loss-of-function 23555276, 8646779, 22129891, 21423803, 20492666, 25416039 -CDKN1B G9R Likely Oncogenic Loss-of-function 21289244 -CDKN1B V109G Inconclusive Inconclusive 22823061, 23652671 -CDKN2A D74N Oncogenic Loss-of-function 10491434, 19260062 -CDKN2A P81T Oncogenic Loss-of-function 20340136, 19260062, 10389768 -CDKN2A E69G Oncogenic Loss-of-function 20340136, 19260062 -CDKN2A D108H Likely Oncogenic Likely Loss-of-function 12606942 -CDKN2A D84V Oncogenic Loss-of-function 10491434 -CDKN2A R79P Oncogenic Loss-of-function 7647780 -CDKN2A R87W Oncogenic Loss-of-function 10491434, 19260062 -CDKN2A N71I Oncogenic Loss-of-function 20340136 -CDKN2A R112G Oncogenic Loss-of-function 20340136 -CDKN2A Deletion Oncogenic Loss-of-function 24071852, 9516223 -CDKN2A P81L Oncogenic Loss-of-function 20340136, 19260062, 10389768 -CDKN2A L32P Oncogenic Loss-of-function 20340136 -CDKN2A H83N Likely Oncogenic Loss-of-function 9660926 -CDKN2A N71S Oncogenic Loss-of-function 10491434 -CDKN2A L97R Oncogenic Loss-of-function 20340136, 19260062 -CDKN2A L16P Oncogenic Loss-of-function 20340136 -CDKN2A P114L Oncogenic Loss-of-function 19260062, 8755727 -CDKN2A G35A Likely Oncogenic Loss-of-function 20340136, 19260062 -CDKN2A D84H Likely Oncogenic Loss-of-function 8755727, 10498896 -CDKN2A A60R Oncogenic Loss-of-function 20340136, 19260062 -CDKN2A T77P Oncogenic Loss-of-function 19260062 -CDKN2A S56I Oncogenic Loss-of-function 20340136 -CDKN2A P73L Oncogenic Loss-of-function 7647780 -CDKN2A R99P Oncogenic Loss-of-function 20340136, 19260062 -CDKN2A G101W Oncogenic Loss-of-function 10491434, 20340136, 19260062, 8755727 -CDKN2A Q50P Oncogenic Loss-of-function 14508519 -CDKN2A G67S Oncogenic Loss-of-function 20340136, 19260062 -CDKN2A R80L Oncogenic Loss-of-function 10491434 -CDKN2A R80P Likely Oncogenic Likely Loss-of-function 10491434 -CDKN2A Q50* Oncogenic Loss-of-function 7987387 -CDKN2A R87P Oncogenic Loss-of-function 10491434, 19260062, 9607312 -CDKN2A D84Y Oncogenic Loss-of-function 10498896 -CDKN2A H83Y Oncogenic Loss-of-function 10491434, 9324288 -CDKN2A N71K Oncogenic Loss-of-function 20340136 -CDKN2A Truncating Mutations Likely Oncogenic Likely Loss-of-function 20340136, 9324288, 8603820 -CDKN2A A60V Likely Oncogenic Loss-of-function 20340136, 19260062 -CDKN2A D84N Likely Oncogenic Loss-of-function 8755727, 7777061, 10498896 -CDKN2A G35V Likely Oncogenic Loss-of-function 20340136, 19260062 -CDKN2A M53I Oncogenic Loss-of-function 20340136, 19260062 -CDKN2A A148T Inconclusive Inconclusive 15879498, 8603820, 7647780 -CDKN2A R87L Oncogenic Loss-of-function 10491434, 9607312 -CDKN2A A57V Oncogenic Loss-of-function 19260062 -CDKN2A D74Y Likely Oncogenic Loss-of-function 10491434, 19260062 -CDKN2A D108N Likely Oncogenic Likely Loss-of-function 12417717 -CDKN2A A36P Oncogenic Loss-of-function 20340136 -CDKN2A V118D Oncogenic Loss-of-function 7647780 -CDKN2A G93W Likely Oncogenic Loss-of-function 7647780 -CDKN2A I49S Oncogenic Loss-of-function 20340136 -CDKN2A D84G Oncogenic Loss-of-function 10491434 -CDKN2A E88K Oncogenic Loss-of-function 10498896 -CDKN2A A68T Oncogenic Loss-of-function 20340136 -CDKN2A V126D Oncogenic Loss-of-function 20340136 -CDKN2A G35R Likely Oncogenic Loss-of-function 20340136, 19260062 -CDKN2A G67R Oncogenic Loss-of-function 20340136, 19260062 -CDKN2A G23D Oncogenic Loss-of-function 20340136, 19260062 -CDKN2A P114S Oncogenic Loss-of-function 19260062, 8755727 -CDKN2A P48L Oncogenic Loss-of-function 10491434 -CDKN2A R24P Oncogenic Loss-of-function 20340136 -CDKN2B Truncating Mutations Likely Oncogenic Likely Loss-of-function 12032783, 9479825, 11485924 -CDKN2B E35* Oncogenic Loss-of-function 25873077 -CDKN2B D86N Oncogenic Loss-of-function 23715670, 25873077 -CDKN2B Hypermethylation Oncogenic Loss-of-function 19064397, 17489980 -CDKN2B P40T Oncogenic Loss-of-function 25873077 -CDKN2B A23E Oncogenic Loss-of-function 25873077 -CDKN2B Deletion Oncogenic Loss-of-function 12032783, 8078588, 9479825 -CDKN2C Deletion Likely Oncogenic Likely Loss-of-function 18829482, 21994415 -CDKN2C Truncating Mutations Likely Oncogenic Likely Loss-of-function -ASXL1 Deletion Likely Oncogenic Likely Loss-of-function 24255920, 22897849, 24218140 -ASXL1 Truncating Mutations Likely Oncogenic Likely Loss-of-function 19388938, 24216483, 22897849, 21455215, 26095772 -ERBB2 G309A Oncogenic Gain-of-function 23220880, 22908275 -ERBB2 Y1248F Likely Neutral Loss-of-function 1671296 -ERBB2 D808N Likely Oncogenic Likely Gain-of-function 25435280 -ERBB2 Y803N Inconclusive Inconclusive 18413839 -ERBB2 G776S Likely Oncogenic Gain-of-function 18039657 -ERBB2 G292R Likely Oncogenic Likely Gain-of-function 24997986 -ERBB2 Y772_A775dup Oncogenic Gain-of-function 23220880, 16843263, 22908275 -ERBB2 D769A Likely Neutral Loss-of-function 23843458 -ERBB2 T216S Likely Neutral Likely Neutral 22908275, 18772396, 18772890 -ERBB2 G660D Likely Oncogenic Gain-of-function 24317180, 26545934 -ERBB2 N857S Likely Oncogenic Likely Gain-of-function 22046346 -ERBB2 T798M Likely Oncogenic Likely Gain-of-function 22046346 -ERBB2 R896C Oncogenic Gain-of-function 23220880 -ERBB2 Amplification Oncogenic Gain-of-function 23204226, 12124352, 2885917, 24656976, 10716706, 11571643 -ERBB2 C311R Oncogenic Gain-of-function 22908275, 18772890 -ERBB2 G778_P780dup Oncogenic Gain-of-function 23220880 -ERBB2 R143Q Likely Neutral Likely Neutral 24971884 -ERBB2 N319D Likely Neutral Likely Neutral 22908275, 18772396, 18772890, 23389443 -ERBB2 E321G Oncogenic Gain-of-function 22908275, 18772890 -ERBB2 S310Y Oncogenic Gain-of-function 24516025, 24997986, 22908275, 26358791 -ERBB2 M774_A775insAYVM Oncogenic Gain-of-function 17311002 -ERBB2 L726I Likely Oncogenic Gain-of-function 17638894 -ERBB2 Exon 20 insertions/deletions Oncogenic Gain-of-function 16775247, 23220880, 16843263, 23610105, 21353324, 22649146, 22325357, 25899785 -ERBB2 L785F Inconclusive Inconclusive 18413839 -ERBB2 C630Y Inconclusive Inconclusive 18413839 -ERBB2 L726F Likely Oncogenic Likely Gain-of-function 18413839, 25435280 -ERBB2 L869R Likely Oncogenic Likely Gain-of-function 21531810, 26305917, 16397024 Hyman et al. Abstract# PD5-05, AACR 2016 http://cancerres.aacrjournals.org/content/76/4_Supplement/PD5-05 -ERBB2 L755S Oncogenic Gain-of-function 22046346, 18413839, 23220880 -ERBB2 V842I Oncogenic Gain-of-function 24997986, 23220880 -ERBB2 E265K Likely Oncogenic Likely Gain-of-function 24997986 -ERBB2 L915M Inconclusive Inconclusive 18413839 -ERBB2 S653C Oncogenic Gain-of-function 24971884 -ERBB2 D769H Oncogenic Gain-of-function 23220880, 23843458 -ERBB2 V773A Likely Oncogenic Likely Gain-of-function 22046346, 26619011, 16299242 -ERBB2 D769Y Oncogenic Gain-of-function 23220880 -ERBB2 D821N Likely Oncogenic Likely Gain-of-function 18413839 -ERBB2 G309E Oncogenic Gain-of-function 22908275 -ERBB2 V794M Likely Oncogenic Likely Gain-of-function 25435280 -ERBB2 S760A Likely Neutral Likely Neutral 23220880 -ERBB2 E719K Inconclusive Inconclusive 18413839 -ERBB2 L755_T759del Oncogenic Gain-of-function 23220880, 15118073, 15329413, 15118125 -ERBB2 E717K Inconclusive Inconclusive 18413839 -ERBB2 G776delinsLC Oncogenic Gain-of-function 26545934 -ERBB2 C334S Oncogenic Gain-of-function 22908275, 18772890 -ERBB2 Exon 20 insertions Oncogenic Gain-of-function 16775247, 23220880, 16843263, 23610105, 21353324, 22649146, 22325357, 25899785 -ERBB2 K753A Likely Neutral Loss-of-function 22393464, 23680147 -ERBB2 V750E Likely Neutral Likely Neutral 22908275, 18772396, 18772890, 23389443 -ERBB2 L49H Likely Neutral Likely Neutral 22908275, 18772396, 18772890, 23389443 -ERBB2 S783P Inconclusive Inconclusive 18413839 -ERBB2 H878Y Likely Oncogenic Gain-of-function 22046346, 25853726 -ERBB2 D277H Likely Oncogenic Likely Gain-of-function 24971884 -ERBB2 K753E Inconclusive Inconclusive 27697991 -ERBB2 S310F Oncogenic Gain-of-function 24516025, 24997986, 22908275, 26358791 -ERBB2 S335C Likely Oncogenic Likely Gain-of-function 23630663 -ERBB2 V777M Likely Neutral Likely Neutral 18039657, 25720673 -ERBB2 A775_G776insYVMA Oncogenic Gain-of-function 17311002 -ERBB2 V777L Oncogenic Gain-of-function 24516025, 22046346, 23220880 -ERBB2 V777A Likely Oncogenic Likely Gain-of-function 26619011, 22908275, 18772396, 18772890, 23389443 -ERBB2 Y835F Likely Neutral Likely Loss-of-function 23220880 -ERBB2 I767M Oncogenic Gain-of-function 25994018, 23220880 -ERBB2 D845A Likely Neutral Loss-of-function 22908275 -ERBB2 P780L Likely Oncogenic Likely Gain-of-function 18413839 -ERBB2 S1002R Inconclusive Inconclusive 18413839 -ERBB2 L866M Oncogenic Gain-of-function 26243863 -ERBB2 T862A Oncogenic Gain-of-function 22046346 -ERBB2 T733I Likely Oncogenic Likely Gain-of-function 18413839, 16397024 -ERBB2 E719G Inconclusive Inconclusive 18413839 -ERBB2 E812K Inconclusive Inconclusive 18413839 -ERBB2 K753M Likely Neutral Loss-of-function 16489002 -ERBB2 T798I Likely Oncogenic Likely Switch-of-function 18413839, 28274957 -ERBB2 R678Q Likely Oncogenic Likely Gain-of-function 24971884, 23220880 -ERBB2 V839G Inconclusive Inconclusive 18413839 -ERBB2 L755P Oncogenic Gain-of-function 22046346 -ERBB2 G776_V777insYVMA Oncogenic Gain-of-function 16843263 -ERBB2 V659E Oncogenic Gain-of-function 1671296, 7821711 -ERBB2 G776delinsVC Oncogenic Gain-of-function 26545934 -ERBB3 V104M Oncogenic Gain-of-function 23680147 -ERBB3 P262H Oncogenic Gain-of-function 23680147 -ERBB3 A232V Oncogenic Gain-of-function 23680147 -ERBB3 T389K Oncogenic Gain-of-function 23680147 -ERBB3 S846I Oncogenic Gain-of-function 23680147 -ERBB3 Q809R Oncogenic Gain-of-function 23680147 -ERBB3 R669C Inconclusive Inconclusive 23741632 -ERBB3 Amplification Oncogenic Gain-of-function 20418034, 24886126, 25739551 -ERBB3 G284R Oncogenic Gain-of-function 23680147 -ERBB3 V104L Oncogenic Gain-of-function 23680147 -ERBB3 E928G Oncogenic Gain-of-function 23680147 -ERBB3 V714M Likely Neutral Likely Neutral 23680147 -ERBB3 A1131T Inconclusive Inconclusive 23741632 -ERBB4 E542K Oncogenic Gain-of-function 19718025 -ERBB4 G936R Inconclusive Inconclusive 21701703 -ERBB4 K935I Oncogenic Gain-of-function 26050618 -ERBB4 E872K Oncogenic Gain-of-function 19718025 -ERBB4 H618P Likely Neutral Neutral 26050618 -ERBB4 EZR-ERBB4 Fusion Oncogenic Gain-of-function 24727320, 22327623 -ERBB4 M887I Inconclusive Inconclusive 25435280 -ERBB4 T244R Likely Neutral Neutral 26050618 -ERBB4 D595V Oncogenic Gain-of-function 26050618 -ERBB4 E452K Oncogenic Gain-of-function 19718025 -ERBB4 D931Y Likely Oncogenic Gain-of-function 26050618 -ERBB4 Fusions Likely Oncogenic Likely Gain-of-function 24727320 -ERBB4 G785S Inconclusive Inconclusive 25435280 -ERBB4 N181S Likely Neutral Neutral 26050618 -ERBB4 V348L Likely Neutral Neutral 26050618 -ERBB4 R544W Oncogenic Gain-of-function 19718025 -ERBB4 R306S Likely Oncogenic Gain-of-function 26050618 -ERBB4 E317K Oncogenic Gain-of-function 19718025 -ERBB4 E836K Oncogenic Gain-of-function 19718025 -ERBB4 Y285C Oncogenic Gain-of-function 26050618 -ERBB4 E563K Oncogenic Gain-of-function 19718025 -ERBB4 R838Q Inconclusive Inconclusive 25435280 -ERCC2 D513Y Likely Oncogenic Likely Loss-of-function 27504877 -ERCC2 D423N Likely Oncogenic Likely Loss-of-function 27504877 -ERCC2 R631C Likely Oncogenic Likely Loss-of-function 27504877 -ERCC2 N238S Likely Oncogenic Likely Loss-of-function 25096233 -ERCC2 R487W Likely Oncogenic Likely Loss-of-function 27504877 -ERCC2 L461V Likely Oncogenic Likely Loss-of-function 27504877 -ERCC2 D609E Likely Oncogenic Likely Loss-of-function 25096233 -ERCC2 F568fs Likely Oncogenic Likely Loss-of-function 27504877 -ERCC2 G665A Likely Oncogenic Likely Loss-of-function 25096233 -ERCC2 A717G Likely Oncogenic Likely Loss-of-function 27504877 -ERCC2 R592H Likely Neutral Likely Neutral 27504877 -ERCC2 P463L Likely Oncogenic Likely Loss-of-function 25096233 -ERCC2 R450H Likely Neutral Likely Neutral 27504877 -ERCC2 V242F Likely Oncogenic Likely Loss-of-function 25096233 -ERCC2 Y24C Likely Oncogenic Likely Loss-of-function 25096233 -ERCC2 D609G Likely Oncogenic Likely Loss-of-function 25096233 -ERCC2 Amplification Likely Oncogenic Likely Gain-of-function 25096233 -ERCC2 S746fs Likely Oncogenic Likely Loss-of-function 27504877 -ERCC2 Truncating Mutations Likely Oncogenic Likely Loss-of-function -ERCC2 E606G Likely Oncogenic Likely Loss-of-function 25096233 -ERCC2 R601Q Likely Oncogenic Likely Loss-of-function 27504877 -ERCC2 V536M Likely Oncogenic Likely Loss-of-function 27504877 -BRIP1 Truncating Mutations Likely Oncogenic Likely Loss-of-function 16153896, 24040146, 17033622, 21964575, 18628483 -BRIP1 M299I Inconclusive Inconclusive 17145708, 11301010, 14983014 -BRIP1 R173C Oncogenic Loss-of-function 12569564 -BRIP1 R798* Likely Oncogenic Likely Loss-of-function 16153896, 17033622 -BRIP1 K52R Oncogenic Loss-of-function 11301010, 2846277, 8196650, 14983014 -BRIP1 A349P Likely Oncogenic Likely Loss-of-function 20639400, 16116424 -BRIP1 P47A Oncogenic Loss-of-function 11301010, 14983014 -BRIP1 Deletion Likely Oncogenic Likely Loss-of-function 24040146, 21964575, 18628483 -ERCC3 R109* Likely Oncogenic Loss-of-function 27655433 -ERCC3 Truncating Mutations Likely Oncogenic Likely Loss-of-function 16143348, 19942596, 27655433, 8196650 -ERCC4 S786F Oncogenic Loss-of-function 24027083 -ERCC4 Deletion Likely Oncogenic Likely Loss-of-function 9580660, 26074087, 23623386 -ERCC4 E875G Oncogenic Loss-of-function 10499592 -ERCC4 L230P Oncogenic Loss-of-function 23623386 -ERCC4 Truncating Mutations Likely Oncogenic Likely Loss-of-function 9580660, 8887684 -ERCC4 R689S Oncogenic Loss-of-function 24027083, 23623386 -ABL1 M351T Likely Oncogenic Likely Gain-of-function 16046538, 21562040 -ABL1 Y253H Likely Oncogenic Likely Gain-of-function 16482207 -ABL1 E355A Likely Oncogenic Likely Gain-of-function 24456693 -ABL1 Fusions Likely Oncogenic Likely Gain-of-function 21435002 -ABL1 Y253F Oncogenic Gain-of-function 16880519 -ABL1 E459K Likely Oncogenic Likely Gain-of-function 19201023 -ABL1 V299L Likely Oncogenic Likely Gain-of-function 23086624, 18242697 -ABL1 F311L Likely Oncogenic Likely Gain-of-function 21562040 -ABL1 H396P Likely Oncogenic Likely Gain-of-function 21562040, 16424036 -ABL1 L248V Likely Oncogenic Likely Gain-of-function 21562040 -ABL1 F359C Likely Oncogenic Likely Gain-of-function 19798095 -ABL1 L384M Likely Oncogenic Likely Gain-of-function 21562040 -ABL1 L387M Likely Oncogenic Likely Gain-of-function 21562040 -ABL1 D276G Oncogenic Gain-of-function 15510211 -ABL1 E255V Likely Oncogenic Likely Gain-of-function 21562040 -ABL1 F317L Likely Oncogenic Likely Gain-of-function 21562040 -ABL1 E355G Likely Oncogenic Likely Gain-of-function 21562040 -ABL1 F359V Likely Oncogenic Likely Gain-of-function 21562040 -ABL1 T315I Likely Oncogenic Likely Gain-of-function 18794843, 11423618 -ABL1 V379I Likely Oncogenic Likely Gain-of-function 21562040 -ABL1 E279K Likely Oncogenic Likely Gain-of-function 21562040 -ABL1 Q252H Likely Oncogenic Likely Gain-of-function 16046538, 21562040 -ABL1 V289F Likely Oncogenic Likely Gain-of-function 23355941 -ABL1 G250E Likely Oncogenic Likely Gain-of-function 21562040 -ABL1 BCR-ABL1 Fusion Oncogenic Gain-of-function 11345193, 18851712 -ABL1 E281K Likely Oncogenic Likely Gain-of-function 21193419 -ABL1 E255K Likely Oncogenic Likely Gain-of-function 15194504 -ABL1 H396R Likely Oncogenic Likely Gain-of-function 21562040 -ABL1 M244V Likely Oncogenic Likely Gain-of-function 21562040 -CEBPA Truncating Mutations Likely Oncogenic Likely Loss-of-function 11830484, 19322763, 19651529, 18768433, 19075268 -ERF Truncating Mutations Likely Oncogenic Likely Loss-of-function 21548782, 17699159, 17525531, 22198386 -ERG Fusions Likely Oncogenic Likely Gain-of-function 19649210, 23625457, 20585344 -ERG TMPRSS2-ERG Fusion Oncogenic Gain-of-function 22142399, 19396167, 18283340, 17043636 -ERG FUS-ERG Fusion Oncogenic Gain-of-function 8187069, 7970732, 9653171, 25453903 -ERG EWSR1-ERG Fusion Oncogenic Gain-of-function 16357154, 8162068, 25453903 -HLA-A Truncating Mutations Likely Oncogenic Likely Loss-of-function 15546342 -HLA-A 596_619splice Likely Oncogenic Likely Loss-of-function 16216676 -HLA-B Truncating Mutations Likely Oncogenic Likely Loss-of-function 26889905, 19845903, 27807939, 14675390, 28205408 -PDGFRA D1071N Likely Neutral Neutral 23752188 -PDGFRA H845Y Likely Oncogenic Gain-of-function 24132921 -PDGFRA Fusions Likely Oncogenic Likely Gain-of-function 20889717 -PDGFRA V658A Likely Oncogenic Gain-of-function 24132921 -PDGFRA N659K Likely Oncogenic Gain-of-function 15928335 -PDGFRA C456_N468del Oncogenic Gain-of-function 23970477 -PDGFRA C456_R481del Oncogenic Gain-of-function 23970477 -PDGFRA V561_I562insER Oncogenic Gain-of-function 15928335, 12522257 -PDGFRA N870S Likely Neutral Neutral 23752188 -PDGFRA H570R Likely Neutral Neutral 21224473 -PDGFRA BCR-PDGFRA Fusion Likely Oncogenic Gain-of-function 12023981, 12944919, 15034867 -PDGFRA I843del Likely Oncogenic Gain-of-function 22745105 -PDGFRA I834V Likely Neutral Neutral 24132921 -PDGFRA KDR-PDGFRA Fusion Oncogenic Gain-of-function 20889717, 16690743 -PDGFRA FIP1L1-PDGFRA Fusion Oncogenic Gain-of-function 16754777, 19187542, 16645167, 24057647, 12660384, 16690743, 24407160, 16608506, 21224473, 19212337, 12781364, 27021554, 16030188 -PDGFRA W349C Likely Neutral Likely Loss-of-function 23752188 -PDGFRA T674I Likely Oncogenic Likely Gain-of-function 22745105 -PDGFRA E996K Likely Neutral Neutral 23752188 -PDGFRA P577S Likely Oncogenic Gain-of-function 24132921 -PDGFRA Y555C Likely Oncogenic Gain-of-function 25975287, 17087943 -PDGFRA CDK5RAP2-PDGFRA Fusion Oncogenic Gain-of-function 16845659 -PDGFRA V544_L545insAVLVLLVIVIISLI Oncogenic Gain-of-function 23970477 -PDGFRA A633T Likely Oncogenic Likely Gain-of-function 24132921 -PDGFRA E311_K312del Oncogenic Gain-of-function 23970477 -PDGFRA P130S Likely Neutral Likely Neutral 23752188 -PDGFRA I562M Likely Neutral Neutral 21224473 -PDGFRA H845_N848delinsP Oncogenic Gain-of-function 15928335, 12522257, 22745105 -PDGFRA H650Q Oncogenic Gain-of-function 21224473 -PDGFRA S478P Likely Neutral Likely Neutral 22733151, 12949711, 19366796 -PDGFRA N659R Likely Oncogenic Gain-of-function 15928335 -PDGFRA V561D Oncogenic Gain-of-function 17087936, 12949711, 15928335, 19217431, 12522257, 18955458, 22665524, 22745105 -PDGFRA C450_K451insMIEWMI Oncogenic Gain-of-function 23970477 -PDGFRA V561A Oncogenic Likely Gain-of-function 24132921 -PDGFRA N659S Likely Oncogenic Gain-of-function 21224473 -PDGFRA ETV6-PDGFRA Fusion Oncogenic Gain-of-function 17555450 -PDGFRA KIF5B-PDGFRA Fusion Oncogenic Gain-of-function 17555450, 16498388 -PDGFRA Q579R Likely Oncogenic Gain-of-function 24132921 -PDGFRA D842_H845del Likely Oncogenic Gain-of-function 22745105 -PDGFRA V536E Oncogenic Gain-of-function 23752188 -PDGFRA D842Y Likely Oncogenic Gain-of-function 15928335, 24132921, 22745105 -PDGFRA F808L Likely Neutral Loss-of-function 23752188 -PDGFRA D842_I843delinsIM Oncogenic Gain-of-function 15928335, 22745105 -PDGFRA S566_E571delinsR Likely Oncogenic Gain-of-function 15928335, 12522257 -PDGFRA A633V Likely Neutral Neutral 24132921 -PDGFRA R481G Likely Neutral Likely Neutral 21224473 -PDGFRA 560_561insER Oncogenic Gain-of-function 22745105 -PDGFRA D842I Likely Oncogenic Gain-of-function 15928335, 22745105 -PDGFRA Y375_K455del Oncogenic Gain-of-function 20889717, 12569364 -PDGFRA Y849S Likely Oncogenic Gain-of-function 21224473 -PDGFRA G829R Likely Neutral Neutral 23752188 -PDGFRA Y849C Likely Oncogenic Gain-of-function 15146165, 15928335 -PDGFRA R841K Oncogenic Gain-of-function 24132921 -PDGFRA L507P Likely Neutral Likely Neutral 24057647, 21224473 -PDGFRA D846Y Likely Oncogenic Gain-of-function 15928335, 22745105 -PDGFRA Amplification Oncogenic Gain-of-function 21931021, 20685895, 18772890, 22745105, 16357008 -PDGFRA W559_R560del Oncogenic Gain-of-function 26396737 -PDGFRA S584L Likely Oncogenic Gain-of-function 24132921 -PDGFRA D842V Oncogenic Gain-of-function 24132921, 22665524, 23752188, 18794084, 17087936, 12949711, 15928335, 23970477, 19217431, 12522257, 18955458, 22745105, 15685537, 16030188 -PDGFRA D568N Likely Oncogenic Gain-of-function 24132921 -PDGFRA K830R Likely Neutral Neutral 24132921 -PDGFRA N848K Likely Oncogenic Gain-of-function 15928335 -PDGFRA I843_D846del Likely Oncogenic Gain-of-function 18955458, 22745105 -PDGFRA R748G Oncogenic Gain-of-function 21224473 -PDGFRA STRN-PDGFRA Fusion Oncogenic Gain-of-function 17555450 -PDGFRA G853D Oncogenic Gain-of-function 24132921 -PDGFRA D842_M844del Likely Oncogenic Gain-of-function 18794084 -PDGFRA V469A Likely Oncogenic Likely Gain-of-function 23752188 -PDGFRB GIT2-PDGFRB Fusion Likely Oncogenic Likely Gain-of-function 17296564, 18262053 -PDGFRB KIAA1509-PDGFRB Fusion Likely Oncogenic Likely Gain-of-function 12907457 -PDGFRB SPTBN1-PDGFRB Fusion Likely Oncogenic Likely Gain-of-function 18262053 -PDGFRB NIN-PDGFRB Fusion Likely Oncogenic Likely Gain-of-function 15087377 -PDGFRB R561C Inconclusive Inconclusive 23731537 -PDGFRB HIP1-PDGFRB Fusion Oncogenic Gain-of-function 9616134 -PDGFRB RABEP1-PDGFRB Fusion Oncogenic Gain-of-function 11588050 -PDGFRB Amplification Inconclusive Inconclusive 18515258, 18157090, 18612157, 16630177, 21729646, 18670317 -PDGFRB ATF7IP-PDGFRB Fusion Likely Oncogenic Likely Gain-of-function 8168137 -PDGFRB TP53BP1-PDGFRB Fusion Likely Oncogenic Likely Gain-of-function 15492236 -PDGFRB PRKG2-PDGFRB Fusion Likely Oncogenic Likely Gain-of-function 17296564, 18262053 -PDGFRB L658P Likely Neutral Loss-of-function 23255827, 26599395 -PDGFRB E1071W Likely Neutral Likely Loss-of-function 23255827, 26599395 -PDGFRB P660T Inconclusive Inconclusive 23731542 -PDGFRB PDE4DIP-PDGFRB Fusion Likely Oncogenic Likely Gain-of-function 12907457 -PDGFRB ETV6-PDGFRB Fusion Oncogenic Gain-of-function 22271894, 8168137, 19644140, 19100521 -PDGFRB KANK1-PDGFRB Fusion Oncogenic Gain-of-function 21685469 -PDGFRB GOLGA4-PDGFRB Fusion Likely Oncogenic Likely Gain-of-function 20085582 -PDGFRB R987W Likely Neutral Likely Loss-of-function 23255827, 26599395 -PDGFRB WDR48-PDGFRB Fusion Likely Oncogenic Likely Gain-of-function 20085582 -PDGFRB Fusions Likely Oncogenic Likely Gain-of-function 20581310, 8962143, 19806146, 22271894, 8168137, 22897847, 18483217 -PDGFRB EBF1-PDGFRB Fusion Oncogenic Gain-of-function 24186319, 8168137, 22897847, 23835704 -PDGFRB GPIAP1-PDGFRB Fusion Likely Oncogenic Likely Gain-of-function 17296564 -PDGFRB V665A Oncogenic Loss-of-function 26279204 -PDGFRB BIN2-PDGFRB Fusion Likely Oncogenic Likely Gain-of-function 20085582 -PDGFRB CEP85L-PDGFRB Fusion Oncogenic Likely Gain-of-function 23186533, 15492236 -RBM10 Deletion Likely Oncogenic Likely Loss-of-function 26853560, 24000153, 24332178 -RBM10 V354E Oncogenic Loss-of-function 20007775, 24332178 -RBM10 Truncating Mutations Likely Oncogenic Likely Loss-of-function 21910224, 24000153, 22980975, 25079552, 24332178 -KDM5C M1_E165DEL Likely Oncogenic Loss-of-function 25666439 -KDM5C P480L Likely Oncogenic Loss-of-function 25666439 -KDM5C D402Y Likely Oncogenic Loss-of-function 25666439 -KDM5C Overexpression Likely Oncogenic Likely Gain-of-function 25016185 -KDM5C Truncating Mutations Likely Oncogenic Likely Loss-of-function -KDM5C V1075Yfs*2 Likely Oncogenic Loss-of-function 25666439 -ESR1 V534E Likely Neutral Neutral 27986707 -ESR1 Y537N Likely Oncogenic Gain-of-function 24185512, 24398047, 24185510, 9102207, 11322512, 9500442 -ESR1 L536P Likely Oncogenic Gain-of-function 10787412, 9234721, 1630819, 9774463, 15282324 -ESR1 A546D Oncogenic Gain-of-function 27986707 -ESR1 Y537S Oncogenic Gain-of-function 24185512, 24185510, 26836308, 27986707, 8923465, 9398213, 11914066 -ESR1 ESR1-CCDC170 Fusion Oncogenic Gain-of-function 25099679, 22496636, 22101766 -ESR1 V422del Likely Oncogenic Gain-of-function 27986707 -ESR1 ESR1-YAP1 Fusion Oncogenic Gain-of-function 24055055 -ESR1 S432L Likely Neutral Neutral 27986707 -ESR1 D538G Oncogenic Gain-of-function 24185512, 24398047, 24185510, 24217577, 1630819, 26836308, 15282324 -ESR1 L536R Likely Oncogenic Gain-of-function 24185512, 1630819, 15282324 -ESR1 E380Q Likely Oncogenic Gain-of-function 9259327, 1630819, 8114756, 15282324 -ESR1 S463P Likely Oncogenic Likely Gain-of-function 24185512, 1630819, 15282324 -ESR1 L536Q Likely Oncogenic Gain-of-function 24185510, 1630819, 15282324 -ESR1 L536H Likely Oncogenic Gain-of-function 1630819, 15282324, 15159406 -ESR1 Y537C Likely Oncogenic Gain-of-function 24398047, 24185510, 1630819, 11322512, 9500442, 15282324 -ESR1 L469V Likely Oncogenic Gain-of-function 1630819, 27986707, 15282324 -ESR1 Fusions Likely Oncogenic Likely Gain-of-function 25099679, 24055055 -ETV1 EWSR1-ETV1 Fusion Oncogenic Gain-of-function 16357154, 7700648, 25453903 -ETV1 Amplification Oncogenic Gain-of-function 23908683, 20160028 -ETV1 Fusions Likely Oncogenic Likely Gain-of-function 23814484, 21298110, 18794142, 23625457, 17671502 -ETV1 TMPRSS2-ETV1 Fusion Oncogenic Gain-of-function 18563191, 23512661 -ETV6 R369W Likely Oncogenic Likely Loss-of-function 25581430, 26522332, 27365488 -ETV6 R418G Likely Oncogenic Loss-of-function 25807284 -ETV6 ETV6-NTRK3 Fusion Oncogenic Gain-of-function 21804605, 18068631, 21148487 -ETV6 385_418del Likely Oncogenic Loss-of-function 25807284 -ETV6 R369Q Likely Oncogenic Likely Loss-of-function 25581430, 26522332, 26102509, 27365488 -ETV6 ETV6-FLT3 Fusion Oncogenic Gain-of-function 16761019 -ETV6 P214L Likely Oncogenic Loss-of-function 25807284 -ETV6 Fusions Likely Oncogenic Likely Gain-of-function 12173038, 10702799, 22578774 -TSC1 Truncating Mutations Likely Oncogenic Likely Loss-of-function 23485365, 24529379, 20301399 -TSC1 F216A Likely Oncogenic Likely Loss-of-function 18397877 -TSC1 H68R Likely Oncogenic Likely Loss-of-function 18397877 -TSC1 L180P Likely Oncogenic Loss-of-function 18830229 -TSC1 R1097H Likely Neutral Neutral 18830229 -TSC1 V128del Likely Oncogenic Loss-of-function 18830229 -TSC1 L191H Likely Oncogenic Loss-of-function 18830229 -TSC1 G305W Likely Neutral Neutral 18830229 -TSC1 M224R Oncogenic Loss-of-function 18830229 -TSC1 H105R Likely Oncogenic Loss-of-function 18397877 -TSC1 N198_F199delinsI Likely Oncogenic Loss-of-function 18830229, 11781698, 17304050 -TSC1 R509Q Likely Neutral Neutral 18830229 -TSC1 T417I Likely Neutral Neutral 18397877, 10570911, 10607950 -TSC1 V220F Likely Oncogenic Likely Loss-of-function 22923433 -TSC1 H206D Likely Oncogenic Loss-of-function 18397877 -TSC1 S35Q Likely Oncogenic Loss-of-function 18397877 -TSC1 F158C Likely Oncogenic Loss-of-function 18397877 -TSC1 R246K Likely Neutral Neutral 18830229 -TSC1 Deletion Likely Oncogenic Likely Loss-of-function 23485365, 24529379, 11741833, 10353610 -TSC1 K82T Likely Neutral Likely Neutral 23857276, 21309039 -TSC1 L117P Likely Oncogenic Loss-of-function 18830229 -TSC1 G305R Likely Neutral Neutral 18830229 -TSC1 G1035S Likely Neutral Neutral 18830229 -IKZF1 Deletion Likely Oncogenic Loss-of-function 27067989, 19129520, 27815723, 26202931 -TSC2 Truncating Mutations Likely Oncogenic Likely Loss-of-function 24529379, 14729330, 25724664, 14561707 -TSC2 V241del Oncogenic Loss-of-function 22903760 -TSC2 R505Q Likely Oncogenic Likely Loss-of-function 22903760 -TSC2 L493V Likely Oncogenic Likely Loss-of-function 22903760 -TSC2 E1552del Oncogenic Loss-of-function 22903760 -TSC2 V1673D Likely Oncogenic Likely Loss-of-function 22903760 -TSC2 F615S Likely Oncogenic Likely Loss-of-function 15483652, 11741832 -TSC2 G1596V Likely Oncogenic Likely Loss-of-function 22903760 -TSC2 V705M Likely Oncogenic Loss-of-function 22903760 -TSC2 R905G Likely Oncogenic Loss-of-function 17120248 -TSC2 Y598C Likely Oncogenic Likely Loss-of-function 22903760 -TSC2 L410R Oncogenic Loss-of-function 22903760 -TSC2 A889P Oncogenic Loss-of-function 22903760 -TSC2 H1620R Oncogenic Loss-of-function 22903760 -TSC2 L493P Likely Oncogenic Gain-of-function 22903760 -TSC2 S1498N Likely Oncogenic Likely Loss-of-function 15972957 -TSC2 L448P Likely Oncogenic Likely Loss-of-function 22903760 -TSC2 V299G Likely Oncogenic Likely Loss-of-function 22903760 -TSC2 T1623I Oncogenic Loss-of-function 22903760 -TSC2 V1673F Likely Oncogenic Likely Loss-of-function 22903760 -TSC2 H597Y Oncogenic Loss-of-function 22903760 -TSC2 R462C Likely Oncogenic Likely Loss-of-function 22903760 -TSC2 L1584R Likely Oncogenic Likely Loss-of-function 22903760 -TSC2 R905Q Likely Oncogenic Loss-of-function 17120248 -TSC2 E75G Likely Oncogenic Likely Loss-of-function 22903760, 27493206 -TSC2 A328P Likely Oncogenic Likely Loss-of-function 22903760 -TSC2 Deletion Oncogenic Likely Loss-of-function 11281455, 25724664, 26540169, 25281918, 14561707 -TSC2 C696Y Likely Oncogenic Loss-of-function 15483652, 11741832 -TSC2 Q1554H Likely Oncogenic Likely Loss-of-function 22903760 -TSC2 T1203K Oncogenic Loss-of-function 22903760 -TSC2 S1653P Oncogenic Loss-of-function 22903760 -TSC2 W1610G Likely Oncogenic Likely Loss-of-function 22903760 -TSC2 V769E Likely Oncogenic Loss-of-function 15483652, 11741832 -TSC2 S1653F Oncogenic Loss-of-function 22903760 -TSC2 V705E Oncogenic Loss-of-function 22903760 -TSC2 R1200W Likely Oncogenic Loss-of-function 21332470 -TSC2 L830R Oncogenic Loss-of-function 22903760 -TSC2 L826P Likely Oncogenic Likely Loss-of-function 15483652, 22903760 -TSC2 G1567D Likely Oncogenic Likely Loss-of-function 22903760 -TSC2 Y1571N Oncogenic Loss-of-function 22903760 -TSC2 L792R Oncogenic Loss-of-function 22903760 -TSC2 P1675L Likely Oncogenic Loss-of-function 11290735, 22903760, 12205112 -TSC2 R905W Likely Oncogenic Loss-of-function 17120248 -TSC2 S1036P Likely Oncogenic Likely Loss-of-function 21332470 -TSC2 P1709L Likely Oncogenic Likely Loss-of-function 22903760 -TSC2 L146R Likely Oncogenic Likely Loss-of-function 22903760 -TSC2 I427M Likely Oncogenic Likely Loss-of-function 22903760 -TSC2 R611Q Likely Oncogenic Loss-of-function 15483652, 11741832 -TSC2 A614D Likely Oncogenic Loss-of-function 15483652, 11741832 -TSC2 R611W Likely Oncogenic Loss-of-function 15483652, 11741832 -TSC2 Q1503P Likely Oncogenic Likely Loss-of-function 22903760 -TSC2 L844R Likely Oncogenic Likely Loss-of-function 22903760 -EWSR1 EWSR1-ATF1 Fusion Likely Oncogenic Likely Gain-of-function 24320889, 21822206, 25364450, 19801966 -EWSR1 EWSR1-CREB1 Fusion Likely Oncogenic Likely Gain-of-function 24320889, 21822206, 25364450, 19801966 -EWSR1 EWSR1-WT1 Fusion Oncogenic Gain-of-function 9591781, 11278460, 10999739, 11237525, 24321497 -EWSR1 EWSR1-ETV4 Fusion Likely Oncogenic Likely Gain-of-function 8605035 -EWSR1 EWSR1-ETV1 Fusion Oncogenic Gain-of-function 25109552 -EWSR1 EWSR1-FEV Fusion Likely Oncogenic Likely Gain-of-function 9121764 -EWSR1 EWSR1-DDIT3 Fusion Oncogenic Gain-of-function 24320889, 7805034, 24790523 -EWSR1 EWSR1-ERG Fusion Oncogenic Gain-of-function 18500345, 8162068, 10749119 -EWSR1 EWSR1-YY1 Fusion Oncogenic Gain-of-function 23630070 -EWSR1 EWSR1-NR4A3 Fusion Oncogenic Gain-of-function 22592656, 16604165 -EWSR1 Fusions Likely Oncogenic Likely Gain-of-function 8605035, 23329308, 21113140, 8834175 NCCN Bone Cancer. Volume# v.2017 https://www.nccn.org/professionals/physician_gls/pdf/bone.pdf -EWSR1 EWSR1-FLI1 Fusion Oncogenic Gain-of-function 17250957, 22930730, 24320889, 11715049, 25453903, 12432241 -ACVR1 R206H Likely Oncogenic Gain-of-function 24705254, 20463014, 22977237, 24769718 -ACVR1 G328E Likely Oncogenic Likely Gain-of-function 24705254, 20463014, 22977237, 24769718 -ACVR1 G328V Likely Oncogenic Gain-of-function 24705254, 20463014, 24705250, 24769718 -ACVR1 Q207E Likely Oncogenic Likely Gain-of-function 24852373 -FOXA1 L455M Likely Oncogenic Likely Loss-of-function 22722839 -FOXA1 Amplification Oncogenic Gain-of-function 22138582, 19470727, 22722839, 21147910, 22960745, 23622249, 19372580, 2298097, 23539448, 25079552, 12234996 -FOXA1 M253K Likely Oncogenic Likely Loss-of-function 23539448 -FOXA1 F400I Likely Oncogenic Likely Loss-of-function 22722839, 23539448 -FOXA1 G87R Likely Oncogenic Likely Loss-of-function 22722839 -FOXA1 S453fs* Likely Oncogenic Likely Gain-of-function 22722839 -FOXA1 L388M Likely Oncogenic Likely Loss-of-function 22722839 -FOXA1 Deletion Likely Oncogenic Likely Loss-of-function 24840332 -MDM2 Amplification Oncogenic Gain-of-function 9671804, 24667108, 15199139, 27194168 -ARID1A Truncating Mutations Likely Oncogenic Likely Loss-of-function 21900401, 24899687, 25625625 -ARID1A Deletion Likely Oncogenic Loss-of-function 22249247, 23097632, 21412130, 23208470 -EZH2 Amplification Oncogenic Gain-of-function 16330673, 12374981, 14500907, 21837672 -EZH2 A677G Likely Oncogenic Switch-of-function 22323599 -EZH2 Y646C Oncogenic Switch-of-function 21078963, 21190999 -EZH2 Y646N Oncogenic Switch-of-function 21078963, 21190999, 24469040, 21810159, 21843048 -EZH2 Y646F Oncogenic Switch-of-function 21078963, 21190999, 27135738, 24469040, 21810159, 21843048 -EZH2 Overexpression Oncogenic Gain-of-function 16330673, 12374981, 14500907, 21837672 -EZH2 Y646H Oncogenic Switch-of-function 21078963, 21190999 -EZH2 Y646S Oncogenic Switch-of-function 21078963, 21190999 -MDM4 G57A Oncogenic Loss-of-function 15199139, 9131587 -MDM4 Amplification Oncogenic Gain-of-function 9523192, 15199139, 7585611 -KLF4 K409Q Likely Oncogenic Likely Gain-of-function 23404370 -RXRA S247Y Inconclusive Inconclusive 24476821 -RXRA S247F Inconclusive Inconclusive 24476821 -MAP3K1 Truncating Mutations Likely Oncogenic Inconclusive 24003131, 24386504 -MAP3K1 E1286V Likely Neutral Likely Neutral 25899310 -MAP3K1 T779fs Likely Oncogenic Likely Loss-of-function 25899310 -MAP3K1 T1481fs Likely Oncogenic Likely Loss-of-function 25899310 -AXIN1 Truncating Mutations Likely Oncogenic Likely Loss-of-function 10700176, 25236910 -AXIN2 Truncating Mutations Likely Oncogenic Likely Loss-of-function 15802015, 17373666 -BAP1 Deletion Likely Oncogenic Likely Loss-of-function 21874000, 26246155, 24633195, 25970771 -BAP1 F81V Likely Oncogenic Loss-of-function 26680512 -BAP1 I47F Likely Oncogenic Loss-of-function 26680512 -BAP1 Truncating Mutations Likely Oncogenic Likely Loss-of-function 21874000, 18757409 -BAP1 E685V Likely Oncogenic Loss-of-function 25830670 -BAP1 C91S Oncogenic Loss-of-function 19815555, 9528852 -BAP1 C91A Likely Oncogenic Loss-of-function 18757409 -BAP1 F170I Likely Oncogenic Loss-of-function 26081045 -BAP1 A95D Likely Oncogenic Loss-of-function 26680512, 24894717, 18757409 -BAP1 G178V Likely Oncogenic Loss-of-function 24894717, 18757409 -MEN1 Truncating Mutations Likely Oncogenic Likely Loss-of-function -MEN1 Deletion Oncogenic Loss-of-function 12746426, 27076911, 9510467, 16740708, 21627674, 14633735, 12941803 -FANCA Deletion Likely Oncogenic Likely Loss-of-function 15522956, 12637330, 24689079, 8374893, 12827451, 14749703 -FANCA L274P Likely Oncogenic Loss-of-function 16720839 -FANCA S858R Likely Oncogenic Loss-of-function 12955722 -FANCA R1055L Likely Oncogenic Likely Loss-of-function 16720839 -FANCA L210R Likely Oncogenic Loss-of-function 16720839 -FANCA Truncating Mutations Likely Oncogenic Likely Loss-of-function 21273304, 15522956, 24689079, 12827451 -FANCA H492R Likely Oncogenic Loss-of-function 16720839, 12444097 -FANCA S1088F Likely Oncogenic Likely Loss-of-function Wilkes et al. Molecular Case Studies, 2016 http://molecularcasestudies.cshlp.org/content/early/2017/05/03/mcs.a001487.short -FANCA Y510C Likely Oncogenic Loss-of-function 16720839 -FANCA W183A Likely Oncogenic Loss-of-function 10468606, 11050007, 11161829 -FANCC Truncating Mutations Likely Oncogenic Likely Loss-of-function 11520787, 16687415, 20509860 -MET Y1230C Likely Oncogenic Gain-of-function 9826708, 18709663 -MET H1094R Oncogenic Gain-of-function 9563489 -MET D1010H Likely Oncogenic Likely Gain-of-function 27666659, 14559814, 16227611, 25898965, 25971938, 15735036, 27343443, 16397241, 26892698, 19096300 -MET X1009_splice Oncogenic Gain-of-function 15735036, 16397241, 19096300 -MET H1094Y Oncogenic Gain-of-function 15064724, 24061647 -MET E168D Likely Oncogenic Gain-of-function 19318576 Ma et al. Abstract# 14010 ASCO 2010 http://hwmaint.meeting.ascopubs.org/cgi/content/abstract/25/18_suppl/14010 -MET X1006_splice Oncogenic Gain-of-function 15735036, 16397241, 19096300 -MET L1195V Oncogenic Gain-of-function 15064724, 24061647 -MET T992I Likely Oncogenic Gain-of-function 25605252, 14559814, 21970370, 11042681, 22973954, 15735036, 17322284 -MET N1100Y Oncogenic Gain-of-function 12460923 -MET V1220I Likely Oncogenic Gain-of-function 19783361 -MET Y1003F Oncogenic Gain-of-function 16227611, 15123609, 11741535 -MET H1106D Likely Oncogenic Likely Gain-of-function 10327054 -MET X1008_splice Oncogenic Gain-of-function 15735036, 16397241, 19096300 -MET M1250T Oncogenic Gain-of-function 10327054, 10871851, 9826715, 15557554 -MET Y1003C Likely Oncogenic Likely Gain-of-function 16227611, 15123609, 11741535 -MET Y1230H Oncogenic Gain-of-function 27666659, 9826708, 9326629 -MET V1188L Oncogenic Gain-of-function 15064724, 24061647 -MET PTPRZ1-MET Fusion Likely Oncogenic Likely Gain-of-function 25135958 -MET F1200I Oncogenic Gain-of-function 24173966, 21697284 -MET Amplification Oncogenic Gain-of-function 16461907, 20129249, 19117057, 17667909, 22869872, 18077425, 17463250 -MET D1010Y Likely Oncogenic Likely Gain-of-function 27666659, 14559814, 16227611, 25898965, 25971938, 15735036, 27343443, 16397241, 19096300 -MET X963_splice Oncogenic Gain-of-function 15735036, 16397241, 19096300 -MET R970C Inconclusive Inconclusive 20670955, 14559814, 22973954 -MET Y1235D Oncogenic Gain-of-function 12460923, 10734314 -MET H1094L Oncogenic Gain-of-function 19783361, 24061647 -MET 963_D1010splice Oncogenic Gain-of-function 15735036, 16397241, 19096300 -MET D1010N Likely Oncogenic Likely Gain-of-function 26892698 -MET Overexpression Oncogenic Gain-of-function 9554529, 9870683, 8077049, 11381087, 15375530, 10698493 -MET V1070E Oncogenic Gain-of-function 25401301 -MET V1092I Oncogenic Gain-of-function 24061647, 10417759 -MET X1007_splice Oncogenic Gain-of-function 15735036, 16397241, 19096300 -MET D1228N Likely Oncogenic Likely Gain-of-function 9826708, 27343442 -MET N375S Inconclusive Inconclusive 16171945, 19723643 -MET Y1003* Likely Oncogenic Likely Gain-of-function 25079552, 16397241 -MET 981_1028splice Oncogenic Gain-of-function 15735036, 16397241, 19096300 -U2AF1 Q157R Oncogenic Switch-of-function 25267526, 25311244 -U2AF1 Q157P Likely Oncogenic Switch-of-function 25267526, 25311244 -U2AF1 S34Y Oncogenic Switch-of-function 22158538, 25267526, 25311244 -U2AF1 S34F Likely Oncogenic Switch-of-function 25965570, 22158538, 25267526, 25311244 -KMT2C Deletion Likely Oncogenic Likely Loss-of-function 23166019, 11891048, 24081332, 24794707, 9834205 -KMT2C Truncating Mutations Likely Oncogenic Likely Loss-of-function 23259788, 19433796, 25537518 -KMT2C A1685S Likely Oncogenic Loss-of-function 25998713, 25151357 -KMT2C S3660L Likely Neutral Likely Neutral 24965397 -PARP1 Truncating Mutations Likely Oncogenic Likely Loss-of-function -FAT1 P4309A Likely Oncogenic Likely Loss-of-function 23354438 -FAT1 A4419S Likely Oncogenic Likely Loss-of-function 23354438 -FAT1 T4511I Likely Oncogenic Likely Loss-of-function 23354438 -FAT1 Truncating Mutations Likely Oncogenic Likely Loss-of-function 24718888, 26905694, 23354438 -FAT1 Deletion Oncogenic Loss-of-function 21617878, 23354438 -ARID1B Truncating Mutations Likely Oncogenic Likely Loss-of-function 23660946, 22233809, 26340334 -ARID1B Deletion Likely Oncogenic Likely Loss-of-function 23202128, 25674384, 26340334 -PIK3CA E453K Oncogenic Gain-of-function 20593314, 21266528, 26627007 -PIK3CA N345K Oncogenic Gain-of-function 18074223, 20593314, 22949682, 17376864 -PIK3CA N1044K Oncogenic Gain-of-function 26627007 -PIK3CA M1043I Oncogenic Gain-of-function 22120714, 17376864 -PIK3CA G118D Likely Oncogenic Gain-of-function 22949682 -PIK3CA E81K Likely Oncogenic Likely Gain-of-function 25915946, 21266528 -PIK3CA M1043V Oncogenic Gain-of-function 17376864 -PIK3CA E542G Inconclusive Inconclusive 17990317, 25054828, 22553375, 25401499 -PIK3CA E545Q Oncogenic Gain-of-function 20593314, 26627007 -PIK3CA E453A Likely Oncogenic Likely Gain-of-function 20593314, 21266528 -PIK3CA I31M Likely Neutral Likely Neutral 26627007 -PIK3CA E110K Likely Oncogenic Likely Gain-of-function 23619167 -PIK3CA C420R Oncogenic Gain-of-function 18074223, 21266528, 22949682 -PIK3CA Q546P Oncogenic Gain-of-function 17626883, 17376864 -PIK3CA R38H Oncogenic Gain-of-function 15930273, 20593314, 17376864 -PIK3CA H1047L Oncogenic Gain-of-function 20593314, 26627007, 22120714, 17376864 -PIK3CA A1020V Likely Neutral Likely Neutral 26627007 -PIK3CA E545A Oncogenic Gain-of-function 20593314, 26627007, 17376864 -PIK3CA Q546K Oncogenic Gain-of-function 27126994, 17376864 -PIK3CA E545G Oncogenic Gain-of-function 20593314, 26627007, 17376864 -PIK3CA T1025S Oncogenic Gain-of-function 17376864 -PIK3CA P447_L455del Likely Oncogenic Likely Gain-of-function 27126994 -PIK3CA K111N Likely Oncogenic Likely Gain-of-function 18074223, 21266528, 26627007, 22949682, 17376864 -PIK3CA Q60K Likely Neutral Likely Neutral 18074223 -PIK3CA H701P Likely Neutral Likely Neutral 18074223, 17376864 -PIK3CA G106R Likely Oncogenic Gain-of-function 21266528 -PIK3CA E542K Oncogenic Gain-of-function 20593314, 16432179, 26627007, 17376864 -PIK3CA E365K Likely Oncogenic Gain-of-function 21266528 -PIK3CA C378R Likely Oncogenic Likely Gain-of-function 17363507 -PIK3CA V344G Inconclusive Inconclusive 27007084, 17050665, 24718026 -PIK3CA E542V Oncogenic Gain-of-function 26627007 -PIK3CA E453Q Likely Oncogenic Likely Gain-of-function 15930273, 20593314 -PIK3CA I391M Likely Neutral Likely Neutral 20530683 -PIK3CA Q546E Oncogenic Gain-of-function 26627007 -PIK3CA D350G Likely Oncogenic Gain-of-function 24265155 -PIK3CA V344A Likely Oncogenic Likely Gain-of-function 20593314, 21266528 -PIK3CA H1047Y Oncogenic Gain-of-function 20593314, 26627007, 17376864 -PIK3CA E116K Likely Neutral Likely Neutral 17376864 -PIK3CA H1047R Oncogenic Gain-of-function 16322248, 19029981, 22960745, 16341083, 22214849, 16432179, 26627007, 21822287, 27126994, 25079552, 22120714, 21324922, 23940356, 25631445, 20593314, 22941189, 22370636, 23787421, 23636398, 17376864 -PIK3CA P449_L455del Likely Oncogenic Gain-of-function 20593314, 21266528, 27126994 -PIK3CA D1029Y Likely Oncogenic Likely Gain-of-function 19394761 -PIK3CA R108H Likely Oncogenic Gain-of-function 18829572 -PIK3CA P539R Oncogenic Gain-of-function 17376864 -PIK3CA R93Q Likely Oncogenic Likely Gain-of-function 21266528 -PIK3CA E545K Oncogenic Gain-of-function 16322248, 20593314, 16432179, 26627007, 17376864 -PIK3CA G106_R108del Likely Oncogenic Likely Gain-of-function 19394761 -PIK3CA R93W Likely Oncogenic Gain-of-function 20593314, 21266528, 22949682 -PIK3CA R115L Likely Neutral Likely Neutral 23619167 -PIK3CA G106V Likely Oncogenic Gain-of-function 15930273, 21266528 -PIK3CA P449T Oncogenic Gain-of-function 20530683 -PIK3CA K111E Oncogenic Gain-of-function 18074223, 21266528, 22949682 -PIK3CA N345I Likely Oncogenic Likely Gain-of-function 20593314, 26627007 -PIK3CA G106D Likely Oncogenic Likely Gain-of-function 27555788, 15930273, 21266528 -PIK3CA A1066V Likely Neutral Likely Neutral 27465249, 22430209 -PIK3CA E78K Inconclusive Inconclusive 27126994 -PIK3CA Q546R Oncogenic Gain-of-function 17626883, 26627007 -PIK3CA G914R Likely Oncogenic Likely Gain-of-function 22228622, 22729224 -PIK3CA Amplification Likely Oncogenic Likely Gain-of-function 21720365, 22960745, 17992665, 23136191, 19706770, 22292935, 22994622, 19697359, 25631445, 24608574, 26876212, 23636398, 27095573, 17803655 Zehir A et al. Nature Medicine, 2017 http://doi:10.1038/nm.4333 -PIK3CA N1068fs*4 Likely Oncogenic Gain-of-function 21703185 -PIK3CA E542Q Likely Oncogenic Likely Gain-of-function 16432179, 26627007, 17376864 -PIK3CA E579K Likely Oncogenic Likely Gain-of-function 17376864 -PIK3CA R88Q Likely Oncogenic Gain-of-function 22949682 -PIK3CB R48W Likely Oncogenic Likely Gain-of-function 18755892, 26000489 -PIK3CB D1067V Oncogenic Gain-of-function 25982275 -PIK3CB E1051K Likely Oncogenic Likely Gain-of-function 18755892, 26000489 -PIK3CB E552K Likely Oncogenic Gain-of-function 16339315 -PIK3CB E633K Likely Oncogenic Likely Gain-of-function 23734178, 20668451 -PIK3CB D1067A Likely Oncogenic Gain-of-function 26759240 -PIK3CB ACPP-PIK3CB Fusion Likely Oncogenic Likely Gain-of-function 26000489, 16432180 -PIK3CB N553S Likely Oncogenic Likely Gain-of-function 18755892, 26000489 -PIK3CB D1067Y Oncogenic Gain-of-function 26759240 -PIK3CB Fusions Likely Oncogenic Likely Gain-of-function 26000489, 16432180 -PIK3CB Amplification Oncogenic Gain-of-function 24418330, 26442967, 16432180, 25533673 -PIM1 E142D Inconclusive Inconclusive 23755147 -PIM1 P123M Likely Neutral Likely Neutral 15808862 -PIM1 L193F Likely Oncogenic Likely Loss-of-function 15808862 -PIM1 N82K Likely Neutral Likely Loss-of-function 15808862 -PIM1 P81S Likely Oncogenic Likely Loss-of-function 15808862 -PIM1 Y53H Inconclusive Inconclusive 23755147 -PIM1 E124Q Inconclusive Inconclusive 23755147 -PIM1 H68Y Likely Oncogenic Likely Gain-of-function 15808862 -PIM1 E135K Inconclusive Inconclusive 23755147, 15808862, 19734423 -PIK3CD E525K Likely Oncogenic Gain-of-function 24136356, 24165795 -PIK3CD E1021K Likely Oncogenic Gain-of-function 24136356, 24165795 -PIK3CD N334K Likely Oncogenic Gain-of-function 24165795 -YAP1 Fusions Likely Oncogenic Likely Gain-of-function 23737213, 25965568, 24553141 -YAP1 Amplification Oncogenic Gain-of-function 16140918, 15586366, 16814713, 24336504, 19952108, 15824737, 8569172, 10092132, 17114655, 20842732, 23502453, 24511017, 12651874, 12208731, 19551889 -YAP1 YAP1-MAMLD1 Fusion Likely Oncogenic Likely Gain-of-function 25965575 -YAP1 YAP1-FAM118B Fusion Likely Oncogenic Likely Gain-of-function 25965575 -YAP1 YAP1-TFE3 Fusion Likely Oncogenic Likely Gain-of-function 23737213 -PIK3R1 E137K Likely Oncogenic Likely Loss-of-function 24367658 -PIK3R1 R574fs Oncogenic Loss-of-function 20713702 -PIK3R1 R348* Oncogenic Loss-of-function 21478295, 25284480, 21984976 -PIK3R1 Deletion Likely Oncogenic Likely Loss-of-function 24229379, 25488983, 25133428 -PIK3R1 W237_Y242del Likely Oncogenic Likely Loss-of-function 24367658 -PIK3R1 T576del Oncogenic Loss-of-function 20713702 -PIK3R1 Q579_L581del Oncogenic Loss-of-function 19962665 -PIK3R1 K379E Oncogenic Loss-of-function 20713702 -PIK3R1 E439del Likely Oncogenic Loss-of-function 20713702 -PIK3R1 R262T Likely Oncogenic Likely Loss-of-function 24367658 -PIK3R1 X434_splice Likely Oncogenic Loss-of-function 25488983, 25133428 -PIK3R1 N564D Oncogenic Loss-of-function 24367658 -PIK3R1 D560Y Likely Oncogenic Loss-of-function 20713702 -PIK3R1 R503W Oncogenic Loss-of-function 25957691, 21984976 -PIK3R1 G376R Likely Oncogenic Loss-of-function 20713702 -PIK3R1 X475_splice Likely Oncogenic Loss-of-function 25488983, 25133428 -PIK3R1 E218* Likely Oncogenic Likely Loss-of-function 24367658 -PIK3R1 K459_S460delinsN Oncogenic Loss-of-function 20713702 -PIK3R1 R162* Likely Oncogenic Likely Loss-of-function 24367658 -PIK3R1 E160* Oncogenic Loss-of-function 25284480, 21984976 -PIK3R1 Truncating Mutations Likely Oncogenic Likely Loss-of-function 25488983, 25284480, 25133428 -PIK3R1 X582_splice Likely Oncogenic Likely Loss-of-function 25488983, 25284480, 25133428 -PIK3R1 N564K Likely Oncogenic Loss-of-function 20713702 -PIK3R1 K288Q Likely Oncogenic Likely Loss-of-function 24367658 -PIK3R1 L370fs Likely Oncogenic Likely Loss-of-function 25284480 -PIK3R1 I559_D560insDKRMNS Oncogenic Loss-of-function 20713702 -PIK3R2 A36E Likely Neutral Likely Neutral 21984976 -PIK3R2 A171V Oncogenic Gain-of-function 21984976 -PIK3R2 K376N Inconclusive Inconclusive 21984976 -PIK3R2 N561D Oncogenic Gain-of-function 21984976 -PIK3R2 G373R Likely Oncogenic Gain-of-function 26520804, 22729224 -PIK3R2 Amplification Likely Oncogenic Likely Gain-of-function 25502460 -PIK3R2 A727V Likely Neutral Likely Neutral 21984976 -PIK3R2 D557H Likely Oncogenic Likely Loss-of-function 26860062, 26520804 -PIK3R2 S273C Likely Neutral Likely Neutral 21984976 -ARID5B Truncating Mutations Likely Oncogenic Likely Loss-of-function Kawamata and Itakura Abstract# LB-150, AACR 2016 http://cancerres.aacrjournals.org/content/76/14_Supplement/LB-150 -HRAS T58I Likely Oncogenic Likely Gain-of-function 26888048 -HRAS A146T Oncogenic Gain-of-function 17054105, 19075190, 20570890, 20147967, 2403644 -HRAS G13V Likely Oncogenic Likely Gain-of-function 9219684, 21993244, 22589270, 18713003 -HRAS K117N Likely Oncogenic Likely Gain-of-function 20570890 -HRAS G13D Likely Oncogenic Likely Gain-of-function 26561417, 9219684, 26037647, 21993244, 22722830, 20147967 -HRAS F28L Likely Oncogenic Gain-of-function 25600866 -HRAS Q61K Oncogenic Gain-of-function 10574788, 18073111, 9219684, 21993244, 20194776 -HRAS A59G Likely Oncogenic Gain-of-function 17084704, 20838576 -HRAS Q22K Likely Oncogenic Likely Gain-of-function 17412879 -HRAS G12A Likely Oncogenic Likely Gain-of-function 9219684, 21993244, 25013473 -HRAS G12D Oncogenic Gain-of-function 9219684, 21993244, 24123531 -HRAS A59T Likely Oncogenic Likely Gain-of-function 1730690 -HRAS G12S Oncogenic Gain-of-function 9219684, 21993244, 20979192, 25284075, 24129065 -HRAS G12V Oncogenic Gain-of-function 9219684, 21993244, 24240680, 22589270 -HRAS Q61H Likely Oncogenic Likely Gain-of-function 10574788, 25705018, 9219684, 21993244, 20194776, 20147967 -HRAS Q61R Likely Oncogenic Likely Gain-of-function 10574788, 9219684, 21993244, 20194776, 25437878 -HRAS A146V Likely Oncogenic Likely Gain-of-function 18247425 -HRAS Q61L Oncogenic Gain-of-function 22256804, 10574788, 9219684, 21993244, 20194776 -HRAS Amplification Likely Oncogenic Likely Gain-of-function 8221670, 3283542, 1855225 -HRAS G13R Likely Oncogenic Likely Gain-of-function 9219684, 21993244 -HRAS G12C Likely Oncogenic Likely Gain-of-function 25705018, 9219684, 21993244, 24256730, 16051643, 26841430 -HRAS P34R Likely Oncogenic Likely Gain-of-function 16474404, 8246952 -HRAS Y64A Likely Oncogenic Likely Gain-of-function 24516166 -HRAS K117R Oncogenic Gain-of-function 17054105, 16443854, 20570890, 24247240, 20147967 -HRAS G13C Likely Oncogenic Likely Gain-of-function 25705018, 9219684, 21993244, 17211612, 21079152 -MLH1 M587V Inconclusive Inconclusive 18206535 -MLH1 R487* Likely Oncogenic Likely Loss-of-function 24362816, 16216036, 15713769 -MLH1 P648S Inconclusive Inconclusive 23435383, 24362816 -MLH1 G67R Likely Oncogenic Likely Loss-of-function 21120944 -MLH1 V716M Likely Neutral Likely Neutral 24362816, 21120944 -MLH1 L749P Inconclusive Inconclusive 23435383, 24362816 -MLH1 L550P Likely Oncogenic Likely Loss-of-function 23435383, 24362816 -MLH1 L622H Inconclusive Inconclusive 23435383, 24362816 -MLH1 L559R Inconclusive Inconclusive 23435383, 24362816 -MLH1 T117M Likely Oncogenic Loss-of-function 24362816, 8566964, 12919140, 11781295 -MLH1 R659P Inconclusive Inconclusive 23435383 -MLH1 K618T Likely Neutral Likely Neutral 24362816, 19863800 -MLH1 K618A Likely Oncogenic Likely Loss-of-function 22426235, 24362816, 18205192 -MLH1 R659L Likely Oncogenic Likely Loss-of-function 23435383 -MLH1 V384D Likely Neutral Likely Neutral 12037578, 24362816 -MLH1 Q689R Likely Neutral Likely Neutral 24362816, 25092538 -MLH1 A120S Oncogenic Loss-of-function 24755471 -MLH1 R659* Oncogenic Loss-of-function 23435383 -MLH1 I219V Likely Neutral Likely Neutral 24362816, 11781295 -MLH1 P648L Likely Oncogenic Loss-of-function 23435383, 24362816 -MLH1 V506A Inconclusive Inconclusive 23435383, 24362816 -MLH1 R265C Oncogenic Loss-of-function 19419416, 18205192, 11781295 -MLH1 N551T Likely Oncogenic Likely Loss-of-function 23435383, 24362816 -MLH1 R217C Likely Neutral Likely Neutral 12810663, 17510385, 11781295 -MLH1 A111P Likely Oncogenic Likely Loss-of-function 20020535 -MLH1 G67W Likely Oncogenic Loss-of-function 16528606, 24362816, 17510385, 9927034 -MLH1 D737V Inconclusive Inconclusive 23435383, 24362816 -MLH1 E172K Inconclusive Inconclusive 24755471, 20668451 -MLH1 P654L Inconclusive Inconclusive 23435383 -MLH1 Truncating Mutations Likely Oncogenic Likely Loss-of-function 12697830, 7892206, 11781295 -MLH1 T82A Likely Oncogenic Loss-of-function 24362816, 22736432 -MLH1 R265S Likely Oncogenic Likely Loss-of-function 20020535, 17210669, 24362816 -MLH1 W714* Likely Oncogenic Loss-of-function 23435383, 24362816 -MLH1 R725C Inconclusive Inconclusive 24362816, 23403630 -MLH1 G101S Likely Oncogenic Likely Loss-of-function 22290698, 24362816, 24278394 -MLH1 L582F Inconclusive Inconclusive 23435383, 24362816 -MLH1 R100* Likely Oncogenic Loss-of-function 15872200, 14512394 -MLH1 R226* Likely Oncogenic Likely Loss-of-function 11343035, 24362816, 9927033 -MLH1 R755S Likely Oncogenic Likely Loss-of-function 23435383, 24362816 -FGF3 Amplification Inconclusive Inconclusive 24265351, 22890726, 10845805, 9205106 -FGF4 Amplification Inconclusive Inconclusive 24265351, 22890726 -KMT2A Truncating Mutations Likely Oncogenic Likely Loss-of-function 25998713 -KMT2A Fusions Likely Oncogenic Likely Gain-of-function 25998713, 23628958, 8681380, 11265751, 18455126 -KMT2A Amplification Inconclusive Inconclusive 17908926, 15378024 -AKT1 Q79E Oncogenic Gain-of-function 23134728 -AKT1 D32Y Likely Neutral Likely Neutral 23134728, 23237847, 19706770 -AKT1 Amplification Likely Oncogenic Gain-of-function 14655756, 12631397, 1409633, 24896186, 17616691, 3037531, 11485901 -AKT1 R23A Oncogenic Gain-of-function 23134728 -AKT1 W80A Likely Oncogenic Gain-of-function 25856301, 18669636, 25551293 -AKT1 G311D Likely Oncogenic Likely Switch-of-function 25551293, 22460905 -AKT1 V270A Oncogenic Gain-of-function 23134728 -AKT1 E17K Oncogenic Gain-of-function 23134728, 20440266, 23741320, 18256540, 21793738, 17611497, 9843996 -AKT1 K39N Likely Neutral Likely Neutral 23134728, 23237847, 19706770 -AKT1 L362R Likely Neutral Neutral 23134728 -AKT1 E191A Oncogenic Gain-of-function 23134728 -AKT1 L321A Oncogenic Gain-of-function 23134728 -AKT1 L52R Oncogenic Gain-of-function 23134728, 27147599, 20886116 -AKT1 T195I Oncogenic Gain-of-function 23134728 -AKT1 D325A Oncogenic Gain-of-function 23134728 -AKT1 E267G Likely Oncogenic Likely Gain-of-function 27147599 -AKT1 L78T Oncogenic Gain-of-function 23134728 -AKT1 R200A Likely Neutral Neutral 23134728 -AKT1 K189N Oncogenic Gain-of-function 23134728 -AKT1 Q79K Likely Oncogenic Gain-of-function 23134728, 20886116, 24265152 -AKT1 K179M Likely Oncogenic Likely Switch-of-function 7774014, 25551293 -AKT1 C77F Likely Oncogenic Likely Gain-of-function 22722193, 23237847 -AKT1 V271A Oncogenic Gain-of-function 23134728 -AKT1 R370C Likely Oncogenic Likely Gain-of-function 27147599 -AKT1 R328A Oncogenic Gain-of-function 23134728 -AKT1 E49K Oncogenic Gain-of-function 19802009 -AKT1 P42T Likely Neutral Likely Neutral 23134728, 23237847, 19706770 -AKT1 L202F Likely Neutral Neutral 23134728 -AKT1 N53A Oncogenic Gain-of-function 23134728 -AKT1 Q59E Likely Neutral Neutral 23134728 -AKT1 E40K Oncogenic Gain-of-function 9690513, 9843996 -AKT1 D323H Likely Oncogenic Gain-of-function 23134728, 20886116 -AKT2 G161V Likely Oncogenic Switch-of-function 25551293 -AKT2 D399N Likely Oncogenic Gain-of-function 19738612 -AKT2 Amplification Oncogenic Gain-of-function 8622988 -AKT2 E17K Oncogenic Gain-of-function 19372382, 24285683, 21979934, 17611497 -AKT2 I289M Oncogenic Gain-of-function 25551293 -AKT2 R368C Likely Oncogenic Gain-of-function 19738612, 25551293 -AKT2 D32H Likely Oncogenic Gain-of-function 19738612 -AKT2 BCAM-AKT2 Fusion Likely Oncogenic Gain-of-function 25733895 -AKT2 K181M Likely Oncogenic Switch-of-function 25551293 -AKT2 H355M Oncogenic Gain-of-function 25551293 -AKT2 R170W Oncogenic Gain-of-function 25551293 -AKT2 Fusions Likely Oncogenic Likely Gain-of-function 25733895 -FGFR1 E664K Likely Neutral Likely Loss-of-function 19733072 -FGFR1 FGFR1-TACC1 Fusion Oncogenic Gain-of-function 22837387, 23558953 -FGFR1 N546K Oncogenic Gain-of-function 24777483, 24806303, 19224897, 24705251, 22820256, 16186508, 23817572, 24140581, 14602678 -FGFR1 Amplification Oncogenic Gain-of-function 24265351, 23658459, 22960745, 26451490, 15863030, 15863033, 21160078, 24476821, 25677745, 17121884 -FGFR1 ERLIN2?FGFR1 Fusion Likely Oncogenic Gain-of-function 23558953 -FGFR1 BCR-FGFR1 Fusion Likely Oncogenic Gain-of-function 11739186, 20226962 -FGFR1 ZNF198-FGFR1 Fusion Likely Oncogenic Gain-of-function 20226962, 10887137, 10935490 -FGFR1 K656E Likely Oncogenic Gain-of-function 15509736, 23817572 -FGFR1 A263V Likely Neutral Likely Neutral 26826182 -FGFR1 Fusions Likely Oncogenic Likely Gain-of-function 23558953 -FGFR1 FGFR1OP1-FGFR1 Fusion Likely Oncogenic Gain-of-function 11689702, 16690081, 21330321, 20226962 -FGFR1 V561M Likely Oncogenic Likely Gain-of-function 15157880, 25686244 -FGFR1 CEP110-FGFR1 Fusion Likely Oncogenic Gain-of-function 10688839, 20226962 -FGFR1 CUX1-FGFR1 Fusion Likely Oncogenic Gain-of-function 21330321 -FGFR3 FGFR3 - BAIAP2L1 Fusion Oncogenic Gain-of-function 23175443 -FGFR3 I538F Likely Neutral Likely Neutral 26992226 -FGFR3 K650T Likely Oncogenic Likely Gain-of-function 11055896, 19749790 -FGFR3 V555M Likely Oncogenic Gain-of-function 26992226 -FGFR3 P572A Likely Neutral Likely Neutral 26992226 -FGFR3 FGFR3-TACC3 Fusion Oncogenic Gain-of-function 25609060, 22837387 -FGFR3 G380R Likely Oncogenic Gain-of-function 12461689, 10646125, 10611230, 21324899 -FGFR3 I538V Likely Oncogenic Gain-of-function 26992226 -FGFR3 N653H Likely Neutral Likely Neutral 26992226 -FGFR3 G697C Likely Neutral Likely Neutral 26992226 -FGFR3 D646Y Likely Neutral Likely Neutral 26992226 -FGFR3 F384L Likely Neutral Likely Neutral 11157491 -FGFR3 A500T Likely Neutral Likely Neutral 26992226 -FGFR3 K650E Likely Oncogenic Gain-of-function 19749790, 11429702 -FGFR3 H643D Likely Neutral Likely Neutral 26992226 -FGFR3 Y647C Likely Oncogenic Likely Gain-of-function 26992226 -FGFR3 A391E Likely Oncogenic Gain-of-function 23437153 -FGFR3 R669G Likely Oncogenic Gain-of-function 26992226 -FGFR3 V677I Likely Neutral Likely Neutral 26992226 -FGFR3 Y373C Oncogenic Gain-of-function 19749790, 16338952, 11429702 -FGFR3 K650R Likely Oncogenic Likely Gain-of-function 11055896, 19749790 -FGFR3 Fusions Likely Oncogenic Likely Gain-of-function 23298836, 23661334, 23558953 -FGFR3 G370C Likely Oncogenic Gain-of-function 12009017 -FGFR3 D641G Likely Oncogenic Gain-of-function 26992226 -FGFR3 N540K Oncogenic Gain-of-function 26992226 -FGFR3 K650M Likely Oncogenic Likely Gain-of-function 11055896, 19749790, 10053006 -FGFR3 S371C Likely Oncogenic Gain-of-function 12009017 -FGFR3 E466K Likely Neutral Likely Neutral 26992226 -FGFR3 G375C Likely Oncogenic Gain-of-function 22529939 -FGFR3 S249C Oncogenic Gain-of-function 19749790, 16338952, 17384684 -FGFR3 K650Q Likely Oncogenic Likely Gain-of-function 11055896, 19749790 -FGFR3 Amplification Oncogenic Gain-of-function 17344846, 20094046, 19821490 -FGFR3 C582F Likely Neutral Likely Neutral 26992226 -FGFR3 IGH-FGFR3 Fusion Oncogenic Gain-of-function 17107900 -FGFR3 K650N Likely Oncogenic Likely Gain-of-function 11055896, 19749790 -FGFR3 R248C Oncogenic Gain-of-function 22203368, 8640234 -FGFR3 K508M Inconclusive Inconclusive 22837387 -FGFR3 G637W Likely Neutral Likely Loss-of-function 26992226 -FGFR3 E627D Likely Neutral Likely Neutral 26992226 -FGFR3 D641N Likely Oncogenic Gain-of-function 26992226 -FGFR3 D617G Likely Neutral Likely Loss-of-function 26992226 -FGFR3 N540S Likely Oncogenic Gain-of-function 26992226 -FGFR3 G382D Likely Oncogenic Likely Gain-of-function 11429702 -SPOP P94A Likely Oncogenic Loss-of-function 19818708, 18218622, 25766326 -SPOP M117I Likely Oncogenic Loss-of-function 19818708, 18218622, 25766326 -SPOP E47K Likely Oncogenic Loss-of-function 19818708, 18218622, 25766326 -SPOP W131A Likely Oncogenic Likely Loss-of-function 19818708, 18218622 -SPOP F133L Likely Oncogenic Loss-of-function 19818708, 18218622, 25274033, 24508459, 23559371 -SPOP S80R Likely Oncogenic Loss-of-function 19818708, 18218622, 25766326 -SPOP N296I Likely Oncogenic Likely Loss-of-function 19818708, 23559371, 24796539 -SPOP D130A Likely Oncogenic Likely Loss-of-function 19818708, 18218622, 22085717 -SPOP Y87N Likely Oncogenic Loss-of-function 19818708, 18218622, 25274033, 24508459, 23559371 -SPOP F102C Likely Oncogenic Loss-of-function 19818708, 18218622, 25274033, 24508459, 23559371 -SPOP E50K Likely Oncogenic Loss-of-function 19818708, 18218622, 25766326 -SPOP R121Q Likely Oncogenic Loss-of-function 19818708, 18218622, 25766326 -SPOP G75R Likely Oncogenic Loss-of-function 19818708, 18218622, 25766326 -SPOP Y87C Likely Oncogenic Loss-of-function 19818708, 18218622, 25274033, 24508459, 23559371 -SPOP D140G Likely Oncogenic Loss-of-function 19818708, 18218622, 25766326 -SPOP W131G Likely Oncogenic Loss-of-function 19818708, 18218622, 25274033, 24508459, 23559371 -SPOP M117V Likely Oncogenic Loss-of-function 19818708, 18218622, 25766326 -SPOP K134N Likely Oncogenic Likely Loss-of-function 19818708, 18218622, 24990631 -SPOP Truncating Mutations Likely Oncogenic Likely Loss-of-function 26344095 -SPOP F133V Likely Oncogenic Loss-of-function 19818708, 18218622, 25274033, 24508459, 23559371 -SPOP K129E Likely Oncogenic Likely Loss-of-function 19818708, 18218622, 24990631 -SPOP F125V Likely Oncogenic Loss-of-function 19818708, 18218622, 25274033, 24508459, 23559371 -SPOP S119N Likely Oncogenic Loss-of-function 19818708, 18218622, 25274033, 24508459, 23559371 -FGFR2 Y375C Likely Oncogenic Gain-of-function 22585574, 22558232 -FGFR2 C278F Likely Oncogenic Likely Loss-of-function 20004243, 16844695 -FGFR2 H213Y Inconclusive Inconclusive 19147536 -FGFR2 K525E Likely Oncogenic Gain-of-function 17803937 -FGFR2 FGFR2-BICC1 Fusion Oncogenic Gain-of-function 24122810, 23558953 -FGFR2 V564I Oncogenic Gain-of-function 23908597 -FGFR2 FGFR2-MGEA5 Fusion Likely Oncogenic Likely Gain-of-function 24550739 -FGFR2 Amplification Oncogenic Gain-of-function 20094046, 20101236 -FGFR2 I642V Likely Oncogenic Likely Loss-of-function 19147536 -FGFR2 E219K Likely Oncogenic Likely Loss-of-function 19147536 -FGFR2 S267_D273dup Oncogenic Gain-of-function 26048680 -FGFR2 W290_I291delinsC Oncogenic Gain-of-function 26048680 -FGFR2 R203C Likely Oncogenic Gain-of-function 23527311, 15908952 -FGFR2 T341P Likely Oncogenic Gain-of-function 9539778 -FGFR2 FGFR2-FAM76A Fusion Oncogenic Gain-of-function 24563622 -FGFR2 N549T Likely Oncogenic Gain-of-function 17803937 -FGFR2 E565G Likely Oncogenic Gain-of-function 23908597 -FGFR2 FGFR2-TACC3 Fusion Oncogenic Gain-of-function 26048680 -FGFR2 FGFR2-AHCYL1 Fusion Oncogenic Gain-of-function 24122810 -FGFR2 E731K Likely Oncogenic Gain-of-function 21928350 -FGFR2 L617F Likely Oncogenic Gain-of-function 23913723 -FGFR2 M535I Oncogenic Gain-of-function 23908597 -FGFR2 K659N Likely Oncogenic Gain-of-function 17803937, 23527311, 17525745 -FGFR2 T730S Likely Neutral Likely Neutral 26048680 -FGFR2 L770V Inconclusive Inconclusive 19147536 -FGFR2 K517R Likely Neutral Likely Loss-of-function 19147536 -FGFR2 G271E Likely Oncogenic Likely Loss-of-function 19147536 -FGFR2 N549K Oncogenic Gain-of-function 23908597, 17525745, 18552176 -FGFR2 K310R Likely Neutral Likely Neutral 18552176 -FGFR2 L617M Oncogenic Gain-of-function 23908597 -FGFR2 N549H Oncogenic Gain-of-function 23908597 -FGFR2 D530N Likely Oncogenic Likely Loss-of-function 19147536 -FGFR2 A648T Likely Oncogenic Likely Loss-of-function 19147536 -FGFR2 K659E Likely Oncogenic Likely Gain-of-function 17525745 -FGFR2 D101Y Likely Oncogenic Likely Gain-of-function 18552176 -FGFR2 K526E Likely Oncogenic Likely Gain-of-function 17803937, 16061565 -FGFR2 C382R Oncogenic Gain-of-function 9136983, 17525745 -FGFR2 P253R Oncogenic Gain-of-function 24265351, 11121055 -FGFR2 N549S Oncogenic Gain-of-function 23908597 -FGFR2 FGFR2-KIAA1967 Fusion Likely Oncogenic Likely Gain-of-function 23558953 -FGFR2 Fusions Likely Oncogenic Likely Gain-of-function 25608663, 26258846, 23558953 -FGFR2 K641N Likely Oncogenic Likely Gain-of-function 23908597 -FGFR2 S252W Oncogenic Gain-of-function 17525745, 18552176 -FGFR2 M391R Likely Oncogenic Gain-of-function 24908667 -FGFR2 FGFR2-CCDC6 Fusion Likely Oncogenic Gain-of-function 23558953 -FGFR2 A389T Likely Neutral Likely Neutral 18552176 -FGFR2 V248D Inconclusive Inconclusive 19147536 -FGFR2 V755I Likely Neutral Likely Neutral 26048680 -FGFR2 FGFR2-CIT Fusion Likely Oncogenic Likely Gain-of-function 23558953 -FGFR2 G701S Inconclusive Inconclusive 19147536 -FGFR2 E475K Likely Neutral Likely Neutral 19147536 -FGFR2 FGFR2?PPHLN1 Fusion Oncogenic Gain-of-function 25608663 -FGFR2 R251Q Likely Oncogenic Likely Loss-of-function 19147536 -FGFR2 K641R Likely Oncogenic Gain-of-function 17803937, 23527311 -FGFR2 E636K Inconclusive Inconclusive 19147536 -FGFR4 Y367C Oncogenic Gain-of-function 19946327 -FGFR4 Amplification Oncogenic Gain-of-function 15863030, 25053532, 20094046, 23344261 -FGFR4 V550E Oncogenic Gain-of-function 19809159, 25219510 -FGFR4 N535K Oncogenic Gain-of-function 19809159 -KDM6A Deletion Likely Oncogenic Likely Loss-of-function 19330029, 25225064, 27028180, 22197486 Walker et al. Abstract #1798, ASH, 2009 http://www.bloodjournal.org/content/114/22/1798?sso-checked=true -KDM6A Truncating Mutations Likely Oncogenic Likely Loss-of-function 19330029, 24633898, 25225064 -ALK I1183T Likely Neutral Neutral 21383740, 25517749 -ALK G1202R Oncogenic Gain-of-function 22277784, 21383740, 26144315, 26698910, 24736079, 24675041 -ALK RANBP2-ALK Fusion Oncogenic Gain-of-function 21030459, 20979472 -ALK G1269S Oncogenic Gain-of-function 22277784, 21383740, 22034911, 24675041 -ALK L1198P Oncogenic Gain-of-function 21948233, 21383740 -ALK L1122V Oncogenic Gain-of-function 21383740, 25421750 -ALK I1171N Oncogenic Gain-of-function 21383740, 25517749, 27049722, 24491302, 25749034 -ALK T1343I Likely Neutral Likely Neutral 21383740, 25517749 -ALK S1206Y Oncogenic Gain-of-function 22277784, 21383740, 26144315, 24675041 -ALK N1178H Oncogenic Gain-of-function 21383740, 25749034 -ALK P1139S Oncogenic Gain-of-function 21383740, 25421750 -ALK RANBP1-ALK Fusion Oncogenic Gain-of-function 21030459 -ALK D1091N Likely Oncogenic Likely Gain-of-function 21383740, 18923525, 23104988, 26786851, 18724359 -ALK H694R Likely Oncogenic Gain-of-function 21847362 -ALK R1192P Oncogenic Gain-of-function 27009859, 21383740, 25517749, 27049722 -ALK G1269A Oncogenic Gain-of-function 22235099, 27009859, 26849637, 23401436, 21948233, 22277784, 21383740, 27049722, 26144315, 26698910, 24675041 -ALK R1464* Likely Neutral Neutral 21383740, 23104988 -ALK S1206C Oncogenic Gain-of-function 21383740, 25421750 -ALK A1234T Likely Neutral Likely Neutral 21383740, 23104988 -ALK V597A Likely Oncogenic Gain-of-function 21847362, 12855999 -ALK R1275L Likely Oncogenic Likely Gain-of-function 23598171 -ALK G1128S Oncogenic Gain-of-function 25749034 -ALK L1240V Oncogenic Gain-of-function 21383740, 23104988 -ALK G1201E Oncogenic Gain-of-function 21383740, 21596819 -ALK R1275Q Oncogenic Gain-of-function 18923523, 21383740, 18923525, 25517749, 26829053, 27049722, 26554404, 22072639 -ALK D1349H Likely Neutral Likely Neutral 21383740, 25517749 -ALK L1152R Oncogenic Gain-of-function 21791641, 21383740, 26144315 -ALK STRN-ALK Fusion Likely Oncogenic Likely Gain-of-function 24613930 -ALK G1128A Oncogenic Gain-of-function 21383740, 25517749, 27049722 -ALK L1196M Oncogenic Gain-of-function 22235099, 23434628, 22277784, 21383740, 25517749, 26144315, 20979473, 26698910, 22034911, 25421750, 21613408, 24675041 -ALK NPM-ALK Fusion Oncogenic Gain-of-function 26133723, 18923525, 26144315, 12424201, 25421750, 12879008, 21613408 -ALK G881D Likely Oncogenic Gain-of-function 21847362 -ALK F1245V Oncogenic Gain-of-function 21383740, 25517749 -ALK C1156F Oncogenic Gain-of-function 21383740, 25749034 -ALK C1156Y Oncogenic Gain-of-function 22235099, 21383740, 26144315, 20979473, 26698910, 25749034, 21613408, 24675041 -ALK Q1064R Oncogenic Gain-of-function 21383740, 25421750 -ALK G1123D Oncogenic Gain-of-function 21948233, 21383740 -ALK I1170S Oncogenic Gain-of-function 21383740, 25517749 -ALK I1250T Likely Neutral Likely Neutral 21383740, 25517749 -ALK E1384K Likely Oncogenic Gain-of-function 21847362 -ALK L1204F Likely Neutral Neutral 21383740, 23104988 -ALK M1328I Oncogenic Gain-of-function 21383740, 24491302 -ALK F1174V Oncogenic Gain-of-function 18923523, 21383740, 27049722, 25421750 -ALK I1171T Oncogenic Gain-of-function 25228534, 21383740, 22034911, 25749034, 24675041, 25736571 -ALK G1286R Likely Neutral Neutral 21383740, 25517749 -ALK I1170N Oncogenic Gain-of-function 21383740, 25517749 -ALK K1062M Oncogenic Gain-of-function 21383740, 21596819, 18923524 -ALK D1203N Likely Oncogenic Likely Gain-of-function 21948233, 25421750, 25749034 -ALK E1210K Oncogenic Gain-of-function 21383740, 22034911 -ALK T1151R Likely Oncogenic Likely Gain-of-function 25071110, 21383740 -ALK KIF5B-ALK Fusion Likely Oncogenic Gain-of-function 26144315, 21613408 -ALK Fusions Likely Oncogenic Likely Gain-of-function 24060861 -ALK F1174S Oncogenic Gain-of-function 21383740, 23104988 -ALK D1270G Likely Neutral Neutral 21383740, 25517749 -ALK Amplification Likely Oncogenic Likely Gain-of-function 21474455, 24356251, 22614325 -ALK F1245C Oncogenic Gain-of-function 21383740, 25517749, 27049722, 26554404, 22034911, 23598171 -ALK A1200V Likely Neutral Neutral 21383740, 23104988 -ALK L1198F Oncogenic Gain-of-function 21383740, 21596819, 26698910, 25421750 -ALK Y1278S Oncogenic Gain-of-function 25071110, 21383740, 25517749, 27049722, 23598171 -ALK F1174L Oncogenic Gain-of-function 21383740, 25517749, 22072639, 18724359, 21030459, 18923523, 27009859, 21948233, 21596819, 20719933, 18923525, 27049722, 26144315, 26554404, 23104988, 18923524, 26786851, 21242967, 21613408 -ALK R1060H Likely Neutral Neutral 21383740, 23104988 -ALK EML4-ALK Fusion Oncogenic Gain-of-function 21030459, 22235099, 25228534, 21791641, 21948233, 22277784, 18923524, 21613408, 24675041 -ALK V1180L Oncogenic Gain-of-function 25228534, 21383740 -ALK M1166R Oncogenic Gain-of-function 21383740, 25517749, 23104988 -ALK G1123S Oncogenic Gain-of-function 21948233, 21383740 -ALK L1152P Oncogenic Gain-of-function 21383740, 24675041 -ALK T1151M Likely Neutral Likely Neutral 27009859, 21383740, 18923525, 25517749, 23104988 -ALK T1151dup Oncogenic Gain-of-function 22277784, 21383740, 26144315, 24675041 -ALK R1231Q Likely Neutral Neutral 21383740, 23104988 -ALK A1099T Likely Neutral Neutral 21383740, 23104988 -ALK I1171S Oncogenic Gain-of-function 27009859, 21383740, 26464158 -ALK S1206R Oncogenic Gain-of-function 21383740, 22034911 -ALK F1174I Oncogenic Gain-of-function 21383740, 23104988, 25749034 -ALK L1196Q Oncogenic Gain-of-function 23239810 -ALK CAD-ALK Fusion Likely Oncogenic Likely Gain-of-function 26633560 -ALK F1174C Oncogenic Gain-of-function 21383740, 26698910, 22034911, 24675041 -ALK T1087I Likely Neutral Neutral 21383740, 23104988 -SDHB S100F Likely Oncogenic Loss-of-function 17639058, 15987702 -RAD54L G325R Likely Oncogenic Loss-of-function 15056673, 10362365 -SDHC R133* Likely Oncogenic Loss-of-function 24423348 -VEGFA Amplification Likely Oncogenic Gain-of-function 24687604, 21743435, 24114200, 21495021 -MPL S505N Likely Oncogenic Likely Gain-of-function 14764528, 8695859 -MPL W515L Oncogenic Gain-of-function 16834459 -MPL W515K Likely Oncogenic Likely Gain-of-function 16868251, 17709604 -MPL P106L Likely Oncogenic Likely Gain-of-function 25538044, 23351976 -PMS1 Q233* Oncogenic Loss-of-function 8072530 -CARM1 S217E Likely Oncogenic Likely Loss-of-function 19843527 -CARM1 S217C Likely Oncogenic Likely Loss-of-function 19843527 -CARM1 S217T Likely Oncogenic Likely Loss-of-function 19843527 -CARM1 S217A Likely Oncogenic Likely Loss-of-function 19843527 -FOXO1 T24A Likely Oncogenic Likely Loss-of-function 17646672, 16670091 -VHL H115R Likely Oncogenic Loss-of-function 24969085 -VHL L158P Likely Oncogenic Loss-of-function 10535940, 10973499, 19602254 -VHL N90I Likely Oncogenic Loss-of-function 10823831 -VHL S111C Likely Oncogenic Loss-of-function 22071692 -VHL R167Q Oncogenic Loss-of-function 10535940, 24755468, 19030229 -VHL L188Q Likely Oncogenic Loss-of-function 19602254 -VHL L63P Likely Oncogenic Loss-of-function 15611064 -VHL Y98N Likely Oncogenic Likely Loss-of-function 10823831, 10535940 -VHL P25L Likely Neutral Likely Neutral 16884327 -VHL L188V Likely Oncogenic Likely Loss-of-function 10823831 -VHL V84L Inconclusive Inconclusive 10823831 -VHL Truncating Mutations Likely Oncogenic Likely Loss-of-function 21386872, 12050673, 12004076, 22825683 -VHL F119S Likely Oncogenic Likely Loss-of-function 14636579 -VHL S68W Likely Oncogenic Loss-of-function 18544564, 15611064 -VHL Deletion Oncogenic Likely Loss-of-function 21386872, 23632291, 25093046, 19764026 -VHL L158V Likely Oncogenic Loss-of-function 19602254 -VHL L128F Likely Neutral Likely Neutral 11865071 -VHL P86H Likely Oncogenic Loss-of-function 10823831, 10535940 -VHL R167W Oncogenic Loss-of-function 25563310, 14973063, 23824745, 12202531 -VHL V155A Likely Oncogenic Loss-of-function 26503325 -VHL A149P Likely Oncogenic Likely Loss-of-function 14636579 -VHL L118P Likely Oncogenic Likely Loss-of-function 14636579 -VHL R64P Likely Oncogenic Loss-of-function 10823831, 15611064 -VHL I151S Likely Oncogenic Likely Loss-of-function 14636579, 27179072 -VHL N150K Likely Oncogenic Likely Loss-of-function 14636579 -VHL L118R Likely Oncogenic Likely Loss-of-function 14636579 -VHL Y112H Likely Oncogenic Likely Loss-of-function 10823831 -VHL S65L Likely Oncogenic Loss-of-function 15611064 -VHL S65A Likely Oncogenic Likely Loss-of-function 26619011, 15611064 -VHL Q164R Likely Oncogenic Loss-of-function 26503325 -VHL Q96P Likely Oncogenic Loss-of-function 10823831 -VHL W117C Likely Oncogenic Loss-of-function 14636579 -VHL R82P Likely Oncogenic Loss-of-function 10823831 -VHL Q145H Likely Neutral Loss-of-function 15611064 -VHL N78S Likely Oncogenic Loss-of-function 19602254 -VHL D121G Likely Oncogenic Likely Loss-of-function 26619011, 11865071 -VHL L158Q Likely Oncogenic Loss-of-function 2706960 -VHL E70K Likely Oncogenic Likely Loss-of-function 15611064 -VHL R69C Likely Oncogenic Loss-of-function 15611064 -VHL G114R Likely Oncogenic Likely Loss-of-function 14636579, 27179072 -VHL H191D Oncogenic Loss-of-function 21685897 -VHL S65W Likely Oncogenic Loss-of-function 15611064 -VHL H115Q Likely Oncogenic Likely Loss-of-function 24969085, 12202531 -VHL Y98H Likely Oncogenic Likely Loss-of-function 10823831 -VHL R200W Oncogenic Loss-of-function 21685897 -MAP2K4 R304* Likely Oncogenic Loss-of-function 21896780 -MAP2K4 R134Q Likely Oncogenic Likely Gain-of-function 21896780, 26619011 -MAP2K4 N234I Oncogenic Loss-of-function 20668451, 15122334 -MAP2K4 R154W Oncogenic Loss-of-function 20668451, 15122334 -MAP2K4 S251N Oncogenic Loss-of-function 20668451, 15122334 -MAP2K4 Truncating Mutations Likely Oncogenic Likely Loss-of-function 21896780 -MAP2K4 R228K Oncogenic Loss-of-function 20668451, 15122334 -MAP2K4 A279T Oncogenic Loss-of-function 21896780, 20668451, 15122334 -MAP2K4 V321M Likely Oncogenic Loss-of-function 21896780 -MAP2K4 P326L Likely Oncogenic Loss-of-function 21896780 -MAP2K4 G85R Oncogenic Loss-of-function 20668451, 15122334 -RRAS2 Q72L Oncogenic Gain-of-function 8052619 -FLT1 Amplification Inconclusive Inconclusive Zehir A et al. Nature Medicine, 2017 http://doi:10.1038/nm.4333 -FLT3 D835Y Oncogenic Gain-of-function 11290608, 23631653, 15256420, 26108694, 24255108 -FLT3 V592G Oncogenic Gain-of-function 18068628 -FLT3 D835V Oncogenic Gain-of-function 11290608, 15256420, 26108694 -FLT3 Y599_D600insPAPQIMSTSTLISENMNIA Oncogenic Gain-of-function 9737679, 11090077, 23631653 -FLT3 K602_W603insYEYDLK Oncogenic Gain-of-function 9737679, 11090077, 23631653 -FLT3 E598_Y599insGLVQVTGSSDNEYFYVDFREYE Oncogenic Gain-of-function 9737679, 11090077, 23631653, 11756186 -FLT3 F594L Oncogenic Gain-of-function 16410449 -FLT3 M664I Likely Oncogenic Likely Gain-of-function 25847190 -FLT3 I867S Oncogenic Gain-of-function 24608088 -FLT3 Y599F Likely Neutral Likely Loss-of-function 16684964 -FLT3 W603_E604insDREYEYDLKW Oncogenic Gain-of-function 9737679, 11090077, 23631653 -FLT3 E612_F613insGYVDFREYEYDLKWEFRPRENLEF Oncogenic Gain-of-function 9737679, 11090077, 23631653, 11756186 -FLT3 D835E Oncogenic Gain-of-function 11290608, 15256420, 26108694 -FLT3 V194M Likely Neutral Neutral 18068628 -FLT3 D324N Likely Neutral Neutral 18068628 -FLT3 E598_Y599insDVDFREYE Oncogenic Gain-of-function 9737679, 11090077, 23631653 -FLT3 A627T Likely Oncogenic Likely Gain-of-function 15374944 -FLT3 I836del Likely Oncogenic Gain-of-function 23878140 -FLT3 D835H Oncogenic Gain-of-function 11290608, 15256420, 26108694 -FLT3 F594_R595insSDNEYFYVDF Oncogenic Gain-of-function 9737679, 11090077, 23631653 -FLT3 S451F Oncogenic Gain-of-function 18068628 -FLT3 Y591D Oncogenic Gain-of-function 16410449 -FLT3 V592A Oncogenic Gain-of-function 16410449 -FLT3 N676K Oncogenic Gain-of-function 23878140 -FLT3 L601_K602insREYEYDL Oncogenic Gain-of-function 9737679, 11090077, 23631653, 11756186 -FLT3 T167A Likely Neutral Neutral 18068628 -FLT3 S840_N841insGS Oncogenic Gain-of-function 9737679, 11090077, 23631653, 12384447 -FLT3 D835del Oncogenic Gain-of-function 15256420 -FLT3 Y364H Likely Neutral Neutral 18068628 -FLT3 K868N Likely Neutral Loss-of-function 27272783 -FLT3 N841I Oncogenic Gain-of-function 15178581 -FLT3 Y572C Oncogenic Gain-of-function 18068628 -FLT3 V557I Likely Neutral Neutral 18068628 -FLT3 D835N Oncogenic Gain-of-function 11290608, 15256420, 26108694 -FLT3 F590G Oncogenic Gain-of-function 16410449 -FLT3 D839G Oncogenic Gain-of-function 24608088 -FLT3 Y599_D600insSTDNEYFYVDFREYEY Oncogenic Gain-of-function 9737679, 11090077, 23631653 -FLT3 N676S Likely Oncogenic Likely Gain-of-function 25847190 -FLT3 V579A Oncogenic Gain-of-function 16410449 -FLT3 D600_L601insDFREYEYD Oncogenic Gain-of-function 9737679, 11090077, 23631653 -FLT3 Y599_D600insEYEYEYEY Oncogenic Gain-of-function 9737679, 11090077, 23631653 -FLT3 D835A Oncogenic Gain-of-function 11290608, 15256420, 26108694 -FLT3 L611_E612insCSSDNEYFYVDFREYEYDLKWEFPRENL Oncogenic Gain-of-function 9737679, 11090077, 23631653, 11756186 -FLT3 R834Q Oncogenic Gain-of-function 18068628 -FLT3 Amplification Likely Oncogenic Gain-of-function 25848357, 27906677 -FLT3 FLT3 internal tandem duplications Oncogenic Gain-of-function 23631653 -FLT3 N676D Likely Oncogenic Likely Gain-of-function 22875611 -FLT3 S451E Oncogenic Gain-of-function 18068628 -FLT3 F691L Oncogenic Gain-of-function 19318574, 23430109 -FLT3 Y842C Oncogenic Gain-of-function 15345593 -FLT3 G831E Likely Neutral Neutral 18068628 -FLT3 M737I Likely Neutral Neutral 18068628 -FLT3 Y599_D600insGLYVDFREYEY Oncogenic Gain-of-function 9737679, 11090077, 23631653, 11756186 -FLT3 D600_L601insFREYEYD Oncogenic Gain-of-function 9737679, 11090077, 23631653 -PMS2 G207E Likely Oncogenic Likely Loss-of-function 19479271, 24027009 -PMS2 T485K Likely Neutral Likely Neutral 15256438, 24362816, 24027009 -PMS2 Truncating Mutations Likely Oncogenic Likely Loss-of-function 12697830, 20487569, 23582141, 21376568, 7892206, 16144131, 9488480 -PMS2 R20Q Oncogenic Loss-of-function 25512458 -PMS2 G857A Likely Neutral Likely Neutral 24362816, 24027009 -PMS2 L585I Likely Neutral Likely Neutral 24362816, 24027009 -PMS2 R802* Likely Oncogenic Likely Loss-of-function 24362816, 16507833 -PMS2 R421* Likely Oncogenic Likely Loss-of-function 24362816 -PMS2 I668V Oncogenic Loss-of-function 25691505 -PMS2 E541K Likely Neutral Likely Neutral 24362816, 24027009 -PMS2 E41A Oncogenic Loss-of-function 20864418, 24027009 -PMS2 R315* Likely Oncogenic Likely Loss-of-function 24362816 -PMS2 S46I Oncogenic Loss-of-function 18602922, 25883011, 23709753, 17557300, 24027009, 2257789, 18709565, 16144131 -PMS2 P470S Likely Neutral Likely Neutral 24362816, 24027009 -PMS2 S46N Oncogenic Loss-of-function 24027009 -PMS2 Deletion Likely Oncogenic Likely Loss-of-function 18602922, 23837913, 16472587 -PMS2 E5K Likely Neutral Likely Neutral 24362816 -PMS2 I18V Likely Neutral Neutral 24362816, 24027009 -SRSF2 P95H Oncogenic Loss-of-function 27135740, 25965569, 26124281, 26261309 -WHSC1 E1099K Oncogenic Gain-of-function 23823660, 24076604 -PPM1D 422_605trunc Likely Oncogenic Gain-of-function 25742468, 24880341, 23907125 -POLD1 Truncating Mutations Likely Oncogenic Likely Loss-of-function -POLE L424V Likely Oncogenic Loss-of-function 23263490, 25228659 -POLE P286H Likely Oncogenic Loss-of-function 25228659 -POLE S459F Likely Oncogenic Loss-of-function 25228659 -POLE S279Y Likely Oncogenic Likely Loss-of-function 25228659, 24472300 -POLE F367S Likely Oncogenic Loss-of-function 21157497, 25228659 -POLE P286S Likely Oncogenic Loss-of-function 25228659 -POLE L424I Likely Oncogenic Loss-of-function 25228659 -POLE V411L Likely Oncogenic Loss-of-function 25228659, 23636398 -POLE S297F Likely Oncogenic Likely Loss-of-function 25228659, 24472300 -POLE S459del Likely Oncogenic Likely Loss-of-function 25228659 -POLE P286R Likely Oncogenic Loss-of-function 25228659, 23636398 -KNSTRN R11K Likely Oncogenic Likely Loss-of-function 25194279 -KNSTRN S24F Oncogenic Loss-of-function 25194279 -KNSTRN P26S Likely Oncogenic Likely Loss-of-function 25194279 -KNSTRN A40E Likely Oncogenic Likely Loss-of-function 25194279 -KNSTRN P28S Likely Oncogenic Likely Loss-of-function 25194279 -PIK3R3 Truncating Mutations Likely Oncogenic Likely Loss-of-function 25424831, 27766312 -APC Truncating Mutations Likely Oncogenic Likely Loss-of-function 11062151, 15561772, 11257105 -APC R640G Oncogenic Loss-of-function 19111562 -APC Deletion Likely Oncogenic Likely Loss-of-function 8259511, 15643602, 25317407, 11867715 -APC N1026S Likely Oncogenic Loss-of-function 18166348 -APC I1307K Likely Oncogenic Likely Loss-of-function 9724771 -APC A290T Likely Oncogenic Likely Loss-of-function 11606402 -RICTOR Amplification Oncogenic Gain-of-function 19934294, 20978191, 26370156, 19185849 -MSH2 Deletion Likely Oncogenic Likely Loss-of-function 9823339, 21970482, 22781090, 23264089, 17250661 -MSH2 Q395* Oncogenic Loss-of-function 24362816 -MSH2 G322D Likely Neutral Likely Neutral 24362816 -MSH2 R389* Oncogenic Loss-of-function 19459153, 26864202, 25430799 -MSH2 Q337* Oncogenic Loss-of-function 24362816 -MSH2 A636P Likely Oncogenic Likely Loss-of-function 12595050, 10528862 -MSH2 R711* Oncogenic Loss-of-function 24362816 -MSH2 R680* Oncogenic Loss-of-function 24362816 -MSH2 L390F Likely Neutral Likely Neutral 24362816 -MSH2 A272V Likely Neutral Likely Neutral 17101317, 21120944 -MSH2 D603N Oncogenic Loss-of-function 21120944, 18951462 -MSH2 S860L Likely Neutral Likely Neutral 24362816, 22102614 -MSH2 S723F Likely Oncogenic Likely Loss-of-function 24362816, 22102614, 26951660 -MSH2 G751R Likely Oncogenic Loss-of-function 24362816, 10732761, 17720936 -MSH2 Truncating Mutations Likely Oncogenic Likely Loss-of-function 11257106, 23391514, 15528792, 10946232 -MSH2 Q429* Oncogenic Loss-of-function 7726159 -MSH2 E580* Oncogenic Loss-of-function 24362816 -MSH2 R383* Oncogenic Loss-of-function 8592341 -MSH2 D603G Inconclusive Inconclusive 24362816 -MSH2 R621* Oncogenic Loss-of-function 8566964 -MSH2 W345* Oncogenic Loss-of-function 24362816 -MSH2 Q816* Oncogenic Loss-of-function 24362816 -MSH2 E483* Oncogenic Loss-of-function 24362816 -IDH1 R132G Oncogenic Switch-of-function 23264629, 23630074, 19935646 -IDH1 G97D Likely Oncogenic Switch-of-function 21996744 -IDH1 E190K Likely Neutral Likely Neutral 27147599 -IDH1 G70D Likely Neutral Loss-of-function 21996744 -IDH1 H133Q Likely Neutral Likely Neutral 21996744 -IDH1 A134D Likely Neutral Loss-of-function 21996744 -IDH1 R132H Oncogenic Switch-of-function 25730874, 23393090, 22763442, 22343901, 23630074, 22343889, 22899282, 19935646 -IDH1 I99M Likely Neutral Likely Neutral 21996744 -IDH1 P33S Likely Neutral Likely Neutral 27147599 -IDH1 Y139D Likely Oncogenic Gain-of-function 21996744 -IDH1 R132S Likely Oncogenic Switch-of-function 21760534, 25257301, 23630074, 21912393, 22033490, 19935646 -IDH1 R49C Likely Neutral Loss-of-function 21996744 -IDH1 R132C Oncogenic Switch-of-function 23630074, 23954893, 19935646 -IDH1 V294M Likely Neutral Likely Neutral 21996744 -IDH1 G123R Likely Neutral Loss-of-function 20171178 -IDH1 R100A Likely Oncogenic Switch-of-function 21996744 -IDH1 I130M Likely Neutral Likely Neutral 21996744 -IDH1 R132Q Likely Oncogenic Likely Switch-of-function 25730874, 23630074, 19935646 -IDH2 R172M Likely Oncogenic Likely Switch-of-function 27147599, 20171147 -IDH2 R172K Oncogenic Switch-of-function 20171147, 25043045 -IDH2 R172G Likely Oncogenic Likely Switch-of-function 21641335, 20171147 -IDH2 R140Q Oncogenic Switch-of-function 20692206, 23264629, 20171147, 25043045, 24440599, 20847235 -IDH2 R172S Oncogenic Switch-of-function 23264629, 20171147 -XPO1 E571K Likely Oncogenic Likely Gain-of-function 21741593, 21642962, 27312795, 26619011, 27479820 -XPO1 C528S Inconclusive Inconclusive 27680702, 23034282 -XRCC2 Deletion Likely Neutral Likely Loss-of-function 22464251, 14678973, 10517641 -XRCC2 R188H Likely Oncogenic Likely Loss-of-function 12023985 -XRCC2 Truncating Mutations Likely Oncogenic Likely Loss-of-function 22464251, 14678973, 10517641 -CREBBP W1502A Likely Oncogenic Loss-of-function 11691934, 21390130 -CREBBP Deletion Likely Oncogenic Likely Loss-of-function 21390130 -CREBBP R1563S Likely Neutral Likely Neutral 21390130 -CREBBP Truncating Mutations Likely Oncogenic Likely Loss-of-function 21390130 -CREBBP R1446C Likely Oncogenic Likely Loss-of-function 21390130 -CREBBP Q1500P Likely Neutral Likely Neutral 21390130 -CREBBP R1446H Likely Oncogenic Likely Loss-of-function 21390130 -DIS3 R780K Oncogenic Loss-of-function 26193331, 24150935 -AR F877L Oncogenic Gain-of-function 23779130, 23842682, 23580326 -AR G248V Inconclusive Inconclusive 25500996 -AR L57Q Likely Neutral Loss-of-function 22403669 -AR G216R Inconclusive Inconclusive 25500996 -AR W742C Oncogenic Gain-of-function 12517791 -AR T878A Oncogenic Gain-of-function 9092797, 2260966, 10363963, 9815822, 25320358 -AR A159T Likely Neutral Likely Loss-of-function 25500996 -AR T878S Oncogenic Gain-of-function 9092797, 2260966, 9815822 -AR Q58_Q59insL Likely Neutral Likely Loss-of-function 25500996 -AR P380R Inconclusive Inconclusive 25500996 -AR Amplification Oncogenic Gain-of-function 7795646, 7511045, 11306464, 12888829, 14702632, 10496349 -AR F876L Likely Oncogenic Likely Gain-of-function 23779130, 2384268 -AR Q58L Inconclusive Inconclusive 12801573, 23637914, 24737579 -AR AR-V7 Oncogenic Gain-of-function 20823238, 19117982, 24449822, 22014572, 23851510, 21552559, 19244107, 20644256 -AR L702H Oncogenic Gain-of-function 11956172, 10835690 -AR W742L Oncogenic Gain-of-function 12517791 -AR H875Y Oncogenic Gain-of-function 9092797, 9815822 -AR L272F Likely Neutral Likely Neutral 25500996 -AR N235K Likely Neutral Likely Loss-of-function 25500996, 11422119 -AR ARv567es Oncogenic Gain-of-function 20823238, 19117982, 24449822, 22014572, 23851510, 21552559, 19244107, 20644256 -AR L57del Likely Neutral Likely Neutral 25500996 -AR Q120E Likely Neutral Likely Neutral 25500996 -ARAF S214F Oncogenic Gain-of-function 24569458, 15520807 -ARAF F351L Oncogenic Gain-of-function 24652991 -ARAF S214C Oncogenic Gain-of-function 24569458, 15520807 -ARAF G322S Likely Oncogenic Gain-of-function 25608663, 24569458 -ARAF S214A Likely Oncogenic Likely Gain-of-function 24569458, 26566875, 15520807 -ARAF Q347_A348del Oncogenic Gain-of-function 24652991 -ARAF S214T Likely Oncogenic Gain-of-function 24569458, 15520807 -ARAF N217I Oncogenic Gain-of-function 25608663, 15520807 -RHOA G17V Oncogenic Loss-of-function 24413737, 24584070 -RHOA E40L Likely Oncogenic Likely Gain-of-function 26619011, 9482732 -RHOA T37A Likely Oncogenic Likely Gain-of-function 19147561, 15993039 -RHOA G17E Likely Oncogenic Likely Loss-of-function 24816255 -RHOA Amplification Oncogenic Gain-of-function 10213513, 15448013, 25104222 -RHOA Overexpression Oncogenic Gain-of-function 10213513, 15448013, 25104222 -RHOA E40Q Likely Oncogenic Likely Gain-of-function 26619011, 9565577 -RHOA Y34F Likely Oncogenic Likely Switch-of-function 24398689, 26619011 -RHOA E40T Likely Oncogenic Likely Gain-of-function 26619011, 9482732 -RHOA Y34C Likely Oncogenic Likely Gain-of-function 26619011, 9565577 -RHOA L57V Oncogenic Loss-of-function 24816253 -RHOA Y42C Oncogenic Loss-of-function 9482732, 24816253, 24816255 -RHOA E40W Likely Oncogenic Likely Loss-of-function 26619011, 9482732 -RHOA G17A Likely Oncogenic Loss-of-function 22491204, 12221096, 16472675 -RHOA G14V Likely Neutral Loss-of-function 24584070, 19515453 -RHOA E40N Likely Oncogenic Likely Switch-of-function 26619011, 9482732 -RHOA T19N Likely Oncogenic Loss-of-function 19147561, 24584070 -RHOA R5Q Likely Oncogenic Likely Loss-of-function 25044415 -NCOR1 Truncating Mutations Likely Oncogenic Likely Loss-of-function 21102521, 7566114 -PPP2R1A R183P Likely Oncogenic Likely Loss-of-function 17174897, 17086192, 18922469 -PPP2R1A S256F Likely Oncogenic Likely Loss-of-function 21435433, 17174897, 17086192, 18922469 -PPP2R1A W257C Likely Oncogenic Likely Loss-of-function 21435433, 17174897, 17086192, 18922469 -PPP2R1A R183Q Likely Oncogenic Likely Loss-of-function 17174897, 17086192, 18922469 -PPP2R1A P179L Likely Oncogenic Likely Loss-of-function 17174897, 17086192, 18922469 -PPP2R1A S256W Likely Oncogenic Likely Loss-of-function 21435433, 17174897, 17086192, 18922469 -PPP2R1A R183W Likely Oncogenic Likely Loss-of-function 17174897, 17086192, 18922469 -PPP2R1A S256Y Likely Oncogenic Likely Loss-of-function 21435433, 17174897, 17086192, 18922469 -PPP2R1A W257G Likely Oncogenic Gain-of-function 21435433, 17174897, 17086192, 18922469, 27272709 -PPP2R1A R258C Inconclusive Inconclusive 17174897, 17086192, 18922469 -PPP2R1A R182W Likely Oncogenic Likely Loss-of-function 21435433, 17174897, 17086192, 18922469, 26168268 -PPP2R1A R258H Inconclusive Inconclusive 17174897, 17086192, 18922469 -PPP2R1A P179R Likely Oncogenic Likely Loss-of-function 17174897, 17086192, 18922469 -PPP2R1A R183G Likely Oncogenic Likely Loss-of-function 17174897, 17086192, 18922469 -SETD2 Deletion Oncogenic Loss-of-function 27282254 McKinney et al. Abstract #1052, ASH 2016 https://ash.confex.com/ash/2016/webprogram/Paper96954.html -SETD2 R1625C Oncogenic Loss-of-function 27528607 -SETD2 Truncating Mutations Likely Oncogenic Likely Loss-of-function 24509477, 25728682, 23417712 -IGF1R G119T Likely Oncogenic Loss-of-function 23045302 -IGF1R G1125A Likely Neutral Likely Loss-of-function 20103656 -IGF1R M1255I Likely Oncogenic Likely Gain-of-function 22778948 -IGF1R A1374V Likely Oncogenic Likely Gain-of-function 22778948 -PPP6C R264C Likely Oncogenic Loss-of-function 23729733 -PPP6C P186S Likely Oncogenic Loss-of-function 23729733 -PPP6C H114Y Oncogenic Loss-of-function 23729733 -PPP6C S270L Likely Oncogenic Loss-of-function 23729733 -CTCF H284Y Likely Oncogenic Likely Loss-of-function 11782357, 24794443, 26619011 -CTCF H284N Likely Oncogenic Likely Loss-of-function 11782357, 24794443, 26619011 -CTCF H284P Likely Oncogenic Likely Loss-of-function 11782357, 24794443, 26619011 -CTCF Deletion Likely Oncogenic Likely Loss-of-function 26330387, 24130125, 19568526 -CTCF Truncating Mutations Likely Oncogenic Likely Loss-of-function 25079317, 24130125, 23636398 -CTCF R339W Likely Oncogenic Switch-of-function 11782357 -IKBKE Amplification Likely Oncogenic Likely Gain-of-function 17574021, 25365225 -MTOR L2431P Oncogenic Gain-of-function 22397650 -MTOR R2505P Oncogenic Gain-of-function 20190810, 24631838, 26255626 -MTOR P2476L Likely Neutral Neutral 20190810 -MTOR E2288K Likely Oncogenic Gain-of-function 23322780 -MTOR T1977K Oncogenic Gain-of-function 27482884 -MTOR A1459P Likely Oncogenic Gain-of-function 24631838 -MTOR T1977R Oncogenic Gain-of-function 24631838 -MTOR R2505Q Likely Neutral Neutral 24631838 -MTOR E2419K Oncogenic Gain-of-function 24625776 -MTOR C1483Y Oncogenic Gain-of-function 24631838 -MTOR A41S Likely Neutral Neutral 24631838 -MTOR T1977S Likely Neutral Neutral 24631838 -MTOR L2230V Oncogenic Gain-of-function 27482884 -MTOR L2427R Likely Oncogenic Gain-of-function 27713405 -MTOR S2215F Oncogenic Gain-of-function 24631838 -MTOR D2512H Likely Oncogenic Likely Gain-of-function 24631838 -MTOR A41T Likely Neutral Neutral 24631838 -MTOR A8S Likely Neutral Likely Neutral 20190810 -MTOR M2327I Likely Oncogenic Gain-of-function 27279227 -MTOR F1888L Oncogenic Gain-of-function 24631838 -MTOR R2430M Likely Neutral Neutral 24631838 -MTOR F1888I Likely Oncogenic Gain-of-function 24631838 -MTOR E2014K Likely Oncogenic Gain-of-function 24625776 -MTOR E1799K Oncogenic Gain-of-function 24631838 -MTOR F1888V Likely Neutral Neutral 24631838 -MTOR Y1463S Likely Oncogenic Likely Gain-of-function 24631838, 26255626 -MTOR V2006L Likely Oncogenic Likely Gain-of-function 24631838, 26619011 -MTOR A1519T Oncogenic Gain-of-function 24631838, 26255626 -MTOR D2512Y Likely Neutral Neutral 24631838 -MTOR K1452N Likely Oncogenic Likely Gain-of-function 24631838, 26255626 -MTOR Q2223K Oncogenic Gain-of-function 24622468 -MTOR S2215T Likely Neutral Neutral 24631838 -MTOR L1460P Oncogenic Gain-of-function 20190810, 24631838, 26255626 -MTOR C1483R Likely Oncogenic Gain-of-function 24631838 -MTOR W1456R Likely Oncogenic Likely Gain-of-function 23322780, 22460905 -MTOR P2273S Likely Oncogenic Gain-of-function 23322780 -MTOR R2152C Likely Neutral Neutral 24631838 -MTOR C1483W Likely Oncogenic Gain-of-function 24631838 -MTOR I2500F Oncogenic Gain-of-function 24631838 -MTOR A2034V Likely Oncogenic Likely Gain-of-function 27279227 -MTOR A41P Likely Neutral Neutral 24631838 -MTOR I2500M Oncogenic Gain-of-function 24631838 -MTOR V2006I Likely Oncogenic Gain-of-function 24631838 -MTOR S2215Y Oncogenic Gain-of-function 20190810, 24631838, 24336570 -MTOR L1433S Oncogenic Gain-of-function 24631838, 26255626 -MTOR R2505* Likely Neutral Neutral 24631838 -MTOR F2108L Likely Oncogenic Likely Gain-of-function 27279227 -MTOR C1483F Oncogenic Gain-of-function 24631838, 26255626 -MTOR D2512G Likely Neutral Neutral 24631838 -MTOR T1977I Likely Oncogenic Gain-of-function 26432419 -TET1 Truncating Mutations Likely Oncogenic Likely Loss-of-function 21057493, 22156206, 19372391 -TET1 MLL-TET1 Fusion Oncogenic Gain-of-function 19144982, 12646957, 23818607, 24323992 -TET1 Deletion Likely Oncogenic Likely Loss-of-function 21625234, 19420352, 25867473 -SMARCA4 Truncating Mutations Likely Oncogenic Likely Loss-of-function 24658002, 24658001, 24658004, 25060813, 18301784 -SMARCA4 T910M Likely Oncogenic Loss-of-function 26842758, 23698369 -SMARCA4 R1189* Likely Oncogenic Loss-of-function 20137775 -SMARCA4 R1093* Oncogenic Loss-of-function 24658001, 24658004 -SMARCA4 Deletion Likely Oncogenic Likely Loss-of-function 21520050, 23139211, 18381774, 11481457, 26942101, 11163203 -SMARCA4 R978* Oncogenic Loss-of-function 24658002, 24658004 -SMARCA4 G1232D Likely Oncogenic Loss-of-function 23698369 -SMARCB1 Truncating Mutations Likely Oncogenic Likely Loss-of-function 23620515, 12138206, 9671307, 23435428, 21076395 -SMARCB1 Deletion Likely Oncogenic Likely Loss-of-function 11313485, 10521299, 11095756, 23074045, 9892189, 12450796, 22797305, 11263494 -FOXP1 Truncating Mutations Likely Oncogenic Likely Loss-of-function 25329375 -FOXP1 R514C Likely Oncogenic Likely Loss-of-function 26647308 -SMO Q477E Likely Oncogenic Likely Gain-of-function 25759020, 25759019 -SMO L412F Likely Oncogenic Gain-of-function 2575902, 25759020, 25759019, 25199678 -SMO T241M Likely Oncogenic Gain-of-function 25759019 -SMO I408V Likely Oncogenic Gain-of-function 2575902, 25759020, 25759019, 25199678 -SMO W281C Likely Oncogenic Gain-of-function 25759020, 25759019, 25199678 -SMO V321M Likely Oncogenic Gain-of-function 2575902, 25759020, 25759019, 25199678 -SMO E518K Likely Neutral Likely Neutral 21123452 -SMO L221R Likely Oncogenic Likely Gain-of-function 25759020, 25759019 -SMO S387N Likely Oncogenic Gain-of-function 25759019 -SMO D384N Likely Oncogenic Likely Gain-of-function 25759020, 25759019 -SMO A459V Likely Oncogenic Gain-of-function 25759019 -SMO H231R Likely Oncogenic Likely Gain-of-function 25759020, 25759019 -SMO D473G Likely Oncogenic Likely Gain-of-function 19726788 -SMO F460L Likely Oncogenic Gain-of-function 2575902, 25759020, 25759019, 25199678 -SMO K575M Likely Oncogenic Likely Gain-of-function 16339184, 12499255 -SMO N219D Likely Oncogenic Likely Gain-of-function 25759020, 25759019 -SMO C469Y Likely Oncogenic Gain-of-function 2575902, 25759020, 25759019, 25199678 -SMO E518A Inconclusive Inconclusive 21123452 -SMO W535L Likely Oncogenic Gain-of-function 25759020, 23636324, 9422511 -SMO Amplification Inconclusive Inconclusive 24202394, 26124204, 20215540 Zehir A et al. Nature Medicine, 2017 http://doi:10.1038/nm.4333 -SMO Q635E Likely Oncogenic Likely Gain-of-function 25759020 -SMO V414A Likely Oncogenic Likely Gain-of-function 25801792, 26619011 -SMO D473H Likely Oncogenic Likely Gain-of-function 19726788 -CARD11 C49Y Likely Oncogenic Gain-of-function 25930198, 23149938 -CARD11 S250P Oncogenic Gain-of-function 23027925, 18323416, 26776161 -CARD11 L251P Oncogenic Gain-of-function 23027925, 18323416, 26776161 -CARD11 F123I Likely Oncogenic Gain-of-function 20799731, 23149938 -CARD11 L225LI Likely Oncogenic Gain-of-function 20799731, 23149938 -CARD11 G116S Likely Oncogenic Gain-of-function 23179749 -CARD11 E127G Likely Oncogenic Gain-of-function 23179749 -CARD11 L232LI Likely Oncogenic Likely Gain-of-function 23027925 -CARD11 E93D Oncogenic Gain-of-function 23149938 -CARD11 G123S Likely Oncogenic Likely Gain-of-function 23027925 -CARD11 D387V Likely Oncogenic Likely Gain-of-function 23027925 -CARD11 Amplification Likely Oncogenic Likely Gain-of-function 18323416 Abubaker et al. Abstract# 4192, AACR 2011 http://cancerres.aacrjournals.org/content/71/8_Supplement/4192 -CARD11 E626K Likely Oncogenic Gain-of-function 26551667 -CARD11 D401N Likely Oncogenic Gain-of-function 25921526 -MEF2B K4E Oncogenic Loss-of-function 23974956, 26245647 -MEF2B N81Y Oncogenic Loss-of-function 23974956 -MEF2B E77K Oncogenic Loss-of-function 23974956 -MEF2B Y69H Oncogenic Loss-of-function 23974956 -MEF2B Amplification Likely Oncogenic Likely Gain-of-function 26245647 -MEF2B D83V Oncogenic Gain-of-function 23974956, 26245647 -CTLA4 T17A Likely Oncogenic Likely Loss-of-function 15018649, 11976786, 20064370, 10082437, 8989248, 18528295, 9459504, 12244107 -ATM V2424G Likely Oncogenic Loss-of-function 18634022, 9463314 -ATM Truncating Mutations Likely Oncogenic Likely Loss-of-function 15928302, 16832357, 16998505 -ATM E1978* Likely Oncogenic Likely Loss-of-function 21514219, 18807267 -ATM D2870A Likely Oncogenic Loss-of-function 9733515, 27304073 -ATM Deletion Likely Oncogenic Likely Loss-of-function 21993670, 16014569 -ATM N2875K Likely Oncogenic Loss-of-function 9733515, 27304073 -ATM D1853N Likely Neutral Likely Neutral 20396981, 18264724, 20799949 -NUP93 G591V Likely Neutral Neutral 26878725 -NUP93 Y629C Likely Neutral Neutral 26878725 -NUP93 Exon 13 deletion Likely Oncogenic Likely Loss-of-function 26878725 -NUP93 K442Nfs* Likely Oncogenic Likely Loss-of-function 26878725 -MAPK1 Amplification Likely Oncogenic Gain-of-function 22961667 -MAPK1 E322K Likely Oncogenic Gain-of-function 24390348, 18813840, 25320010, 26551667, 26181029, 15999996, 21098038, 16324895, 16051177 -CTNNB1 S45A Oncogenic Gain-of-function 12799363 -CTNNB1 G34A Likely Oncogenic Gain-of-function 9635572, 15829978, 9065402 -CTNNB1 G34E Likely Oncogenic Gain-of-function 9635572, 10671680, 9065402 -CTNNB1 S33Y Oncogenic Gain-of-function 9635572, 24735922, 18757411, 9065402 -CTNNB1 S37Y Likely Oncogenic Gain-of-function 20606007, 9635572, 9065402 -CTNNB1 S23R Likely Oncogenic Gain-of-function 9635572, 24735922, 18282277, 9065402 Manring et al. Abstract# 2249, AACR 2012 http://cancerres.aacrjournals.org/content/72/8_Supplement/2249 -CTNNB1 D32N Likely Oncogenic Gain-of-function 9635572, 15064718, 9065402 -CTNNB1 S37C Likely Oncogenic Gain-of-function 9635572, 9537226, 9065402 -CTNNB1 S45del Likely Oncogenic Gain-of-function 9635572, 15064718, 9065402 -CTNNB1 S33F Likely Oncogenic Likely Gain-of-function 9635572, 15829978, 27543871, 18757411, 19582367, 9065402 -CTNNB1 P44A Likely Oncogenic Gain-of-function 9635572, 18282277, 9065402 -CTNNB1 S45P Likely Oncogenic Gain-of-function 9635572, 24735922, 18282277, 9065402 Manring et al. Abstract# 2249, AACR 2012 http://cancerres.aacrjournals.org/content/72/8_Supplement/2249 -CTNNB1 S37A Likely Oncogenic Gain-of-function 15579438, 9635572, 9065402 -CTNNB1 H36P Likely Oncogenic Gain-of-function 9635572, 24735922, 18282277, 9065402 Manring et al. Abstract# 2249, AACR 2012 http://cancerres.aacrjournals.org/content/72/8_Supplement/2249 -CTNNB1 D32A Likely Oncogenic Gain-of-function 15829978 -CTNNB1 I35S Likely Oncogenic Gain-of-function 12375019, 9635572, 24735922, 18282277, 9065402, 10665646 Manring et al. Abstract# 2249, AACR 2012 http://cancerres.aacrjournals.org/content/72/8_Supplement/2249 -CTNNB1 D32G Likely Oncogenic Gain-of-function 9635572, 15064718, 9065402 -CTNNB1 S33A Oncogenic Gain-of-function 15829978 -CTNNB1 S45F Likely Oncogenic Gain-of-function 9635572, 18282277, 26686699, 9065402 -CTNNB1 S33C Oncogenic Gain-of-function 9635572, 19582367, 9065402 -CTNNB1 T41A Oncogenic Gain-of-function 9635572, 24735922, 12799363, 9065402 -CTNNB1 K335I Likely Oncogenic Gain-of-function 15579438, 9635572, 24735922, 9065402 -CTNNB1 N387K Likely Oncogenic Gain-of-function 9635572, 24735922, 9065402 -CTNNB1 D32Y Likely Oncogenic Gain-of-function 9635572, 15064718, 9065402 -CTNNB1 W383R Likely Oncogenic Gain-of-function 15579438, 9635572, 9065402 -CTNNB1 S45Y Likely Oncogenic Gain-of-function 9635572, 9065402, 9419974 -CTNNB1 S37F Likely Oncogenic Gain-of-function 9635572, 22815287, 20303878, 9537226, 9065403, 9065402 -CTNNB1 G34V Likely Oncogenic Gain-of-function 9635572, 10671680, 9671767, 9065402 -MAP2K1 F53S Likely Oncogenic Gain-of-function 17981815, 16439621 -MAP2K1 G128V Likely Oncogenic Likely Gain-of-function 24265153 -MAP2K1 L115P Likely Oncogenic Likely Gain-of-function 19915144 -MAP2K1 L37P Likely Oncogenic Likely Gain-of-function 26566875 -MAP2K1 R47Q Oncogenic Gain-of-function 24982505, 22327936 -MAP2K1 D67N Oncogenic Gain-of-function 25351745, 18060073 -MAP2K1 F129L Likely Oncogenic Gain-of-function 21705440, 19915144, 26399658 -MAP2K1 E203K Oncogenic Gain-of-function 25351745, 22197931 -MAP2K1 I103N Likely Oncogenic Gain-of-function 19915144, 12370306 -MAP2K1 P124S Oncogenic Gain-of-function 24265153, 22197931, 25370473 -MAP2K1 N382H Likely Neutral Likely Neutral 22197931 -MAP2K1 P124L Likely Oncogenic Gain-of-function 19915144, 25370473 -MAP2K1 R49L Oncogenic Gain-of-function 22327936 -MAP2K1 K57E Oncogenic Gain-of-function 26566875, 25370473, 24241536 -MAP2K1 K57T Likely Oncogenic Gain-of-function 26644315 -MAP2K1 D65N Likely Neutral Likely Neutral 26566875 -MAP2K1 Q56_V60del Oncogenic Gain-of-function 26324360 -MAP2K1 E102_I103del Likely Oncogenic Gain-of-function 25351745 -MAP2K1 Q56P Oncogenic Gain-of-function 19915144, 25351745, 22327936, 26566875 -MAP2K1 E144K Likely Oncogenic Gain-of-function 26566875 -MAP2K1 Y130C Likely Oncogenic Gain-of-function 18060073, 26566875 -MAP2K1 Amplification Inconclusive Inconclusive 26399658, 26684394 -MAP2K1 H119P Inconclusive Inconclusive 19915144 -MAP2K1 F53L Oncogenic Gain-of-function 25351745, 21383288, 22197931, 26582713, 26324360, 24241536 -MAP2K1 C121S Likely Oncogenic Gain-of-function 24448821, 25351745, 21383288 -MAP2K1 V211D Inconclusive Inconclusive 19915144, 26399658 -MAP2K1 I111A Likely Oncogenic Likely Gain-of-function 12370306 -MAP2K1 Q58_E62del Likely Oncogenic Gain-of-function 26566875 -MAP2K1 V60M Likely Oncogenic Gain-of-function 26566875 -MAP2K1 F53C Likely Oncogenic Likely Gain-of-function 17981815 -MAP2K1 I111N Inconclusive Inconclusive 19915144 -MAP2K1 I111R Likely Oncogenic Likely Gain-of-function 12370306 -MAP2K1 L115R Inconclusive Inconclusive 19915144 -MAP2K1 S218D Likely Oncogenic Gain-of-function 17981815, 16439621 -MAP2K1 S222D Oncogenic Gain-of-function 17981815, 16439621 -MAP2K1 P306H Likely Oncogenic Gain-of-function 22327936 -MAP2K1 I204T Likely Oncogenic Gain-of-function 22327936 -MAP2K1 K59del Likely Oncogenic Gain-of-function 22389471 -MAP2K1 I111P Likely Oncogenic Likely Gain-of-function 12370306 -MAP2K1 P387S Likely Neutral Likely Neutral 22389471 -MAP2K1 K57N Oncogenic Gain-of-function 25351745, 18632602, 26566875 -MAP2K1 P124Q Likely Oncogenic Gain-of-function 25370473 -MAP2K1 V60E Likely Oncogenic Likely Gain-of-function 24265153 -MAP2K1 E120Q Likely Neutral Likely Neutral 26566875 -MAP2K1 S123T Likely Oncogenic Gain-of-function 26566875 -MAP2K1 K97M Likely Neutral Loss-of-function 22177953, 10567369, 16439621 -MAP2K1 T28I Likely Oncogenic Likely Gain-of-function 26566875 -MAP2K2 Q60P Oncogenic Gain-of-function 24265154, 24055054 -MAP2K2 C125S Oncogenic Gain-of-function 24265153, 21383288 -MAP2K2 F57V Likely Oncogenic Likely Gain-of-function 18042262, 18456719, 16439621 -MAP2K2 K101M Inconclusive Inconclusive 19376813, 22177953, 16439621 -MAP2K2 V35M Oncogenic Gain-of-function 24265153, 21383288 -MAP2K2 S226D Inconclusive Inconclusive 16439621 -MAP2K2 E207K Oncogenic Gain-of-function 22197931 -MAP2K2 S222D Inconclusive Inconclusive 16439621 -MAP2K2 F57C Likely Oncogenic Gain-of-function 16439621 -MAP2K2 F57L Likely Oncogenic Likely Gain-of-function 18042262, 18456719, 16439621 -MAP2K2 N126D Oncogenic Gain-of-function 25487361, 24265153 -MAP2K2 L46F Oncogenic Gain-of-function 24265153, 21383288 -SPEN Truncating Mutations Likely Oncogenic Likely Loss-of-function 26297734 -STAG2 Truncating Mutations Likely Oncogenic Likely Loss-of-function 22417201, 21852505, 24121789, 25010205 -IL7R T244_I245insCPT Oncogenic Gain-of-function 21892159 -SOS1 R552G Likely Oncogenic Gain-of-function 17143285 -SOS1 E846K Likely Oncogenic Gain-of-function 21041952, 17143285 -SOS1 R552S Likely Oncogenic Gain-of-function 27304678 -SOS1 M269R Likely Oncogenic Gain-of-function 27304678, 17143285, 25712082, 24297905 -SOS1 G434R Likely Oncogenic Likely Gain-of-function 27304678 -SOS1 N233Y Likely Oncogenic Gain-of-function 27304678 -MYC T73A Likely Oncogenic Gain-of-function 10378696, 20399964, 21266350, 18642118, 16934487, 19029958, 10706881, 22464321 -MYC IGH-MYC Fusion Oncogenic Gain-of-function 10378696, 22333947, 16934487, 19029958, 22464321 -MYC T73I Likely Oncogenic Likely Gain-of-function 20713710, 26619011, 10825194 -MYC MYC-nick Inconclusive Inconclusive 24696454, 20691906 -MYC IGK-MYC Fusion Oncogenic Gain-of-function 19351371, 10378696, 24957271, 7731690, 8502472, 22333947, 16934487, 21887927, 19029958, 8816814, 19246886, 22464321 -MYC PVT1-MYC Fusion Likely Oncogenic Likely Gain-of-function 22134537, 24298051 -MYC Amplification Oncogenic Gain-of-function 20164920, 10378696, 16934487, 15083194, 19029958, 22464321 -MYC Fusions Likely Oncogenic Likely Gain-of-function 22333947, 16934487 -MYC IGL-MYC Fusion Oncogenic Gain-of-function 10378696, 11034608, 7731690, 8502472, 22333947, 16934487, 19029958, 8816814, 22464321 -MYCN Amplification Oncogenic Gain-of-function 12612655, 16116477, 22035742, 22139329, 23091029, 21533284, 15013217, 9214616 -MYCN P44L Likely Oncogenic Likely Gain-of-function 23334666, 24086065 -SOX9 Deletion Likely Oncogenic Likely Loss-of-function 10446171, 12783851, 9002675 -SOX9 H65Y Likely Oncogenic Loss-of-function 10446171 -SOX9 A19V Likely Neutral Neutral 10446171 -SOX9 Truncating Mutations Likely Oncogenic Likely Loss-of-function 10446171, 27248473 -SOX9 L142P Likely Oncogenic Loss-of-function 27429045 -SOX9 P70R Likely Oncogenic Likely Loss-of-function 10446171 -SOX9 F12L Likely Oncogenic Loss-of-function 10446171 -SOX9 K398A Likely Oncogenic Gain-of-function 15694126 -TET2 W1291R Likely Oncogenic Likely Loss-of-function 24315485 -TET2 D1384V Inconclusive Inconclusive 24315485 -TET2 Y1295A Likely Neutral Likely Neutral 24315485 -TET2 R1262A Likely Neutral Likely Neutral 24315485 -TET2 Y1294A Inconclusive Inconclusive 24315485 -TET2 Y1902A Likely Oncogenic Likely Loss-of-function 24315485 -TET2 N1387A Likely Oncogenic Likely Loss-of-function 24315485 -TET2 M1293A Inconclusive Inconclusive 24315485 -TET2 Truncating Mutations Likely Oncogenic Likely Loss-of-function 21057493, 24315485 -TET2 R1896M Likely Oncogenic Likely Loss-of-function 24315485 -TET2 S1290A Likely Neutral Likely Neutral 24315485 -TET2 K1299E Inconclusive Inconclusive 24315485 -TET2 H1382Y Inconclusive Inconclusive 24315485 -TET2 Deletion Likely Oncogenic Loss-of-function 21625234, 25224413, 21723200, 22017486 -TET2 S1303N Inconclusive Inconclusive 24315485 -TET2 H1904R Likely Oncogenic Likely Loss-of-function 24315485 -MYD88 L265P Oncogenic Gain-of-function 25723115, 26111727 -MYD88 M232T Oncogenic Gain-of-function 25359991 -MYD88 S243N Oncogenic Gain-of-function 24534189, 2179087 -AGO2 R583A Likely Oncogenic Likely Loss-of-function 17891150 -AGO2 Amplification Likely Oncogenic Likely Gain-of-function 18787018, 23775134 -AGO2 A603fs Likely Oncogenic Likely Loss-of-function 20198652, 14749716 -AGO2 R647A Likely Oncogenic Likely Loss-of-function 17891150 -AGO2 Q545A Likely Oncogenic Likely Loss-of-function 17891150 -AGO2 R812A Likely Oncogenic Likely Loss-of-function 17891150 -KMT2B Truncating Mutations Inconclusive Inconclusive 25998713, 16540515, 17429066 -ATR Truncating Mutations Likely Oncogenic Likely Loss-of-function 10691732, 15282542 -ATRX Truncating Mutations Likely Oncogenic Likely Loss-of-function 21719641, 8968741, 24148618, 15591283, 14592816, 18409179, 17609377 -ATRX Deletion Likely Oncogenic Likely Loss-of-function 21719641, 27311324, 24148618, 26741321, 23904111 -CDK12 R882L Likely Oncogenic Loss-of-function 24554720, 21720365, 25712099 -CDK12 Amplification Inconclusive Inconclusive 20932292, 26658019, 21097718 -CDK12 K765R Likely Oncogenic Likely Loss-of-function 24554720, 25712099 -CDK12 Truncating Mutations Likely Oncogenic Likely Loss-of-function 24554720, 21720365, 25712099, 26787825 -CDK12 W719* Likely Oncogenic Loss-of-function 24554720, 25712099 -CDK12 L996F Likely Oncogenic Loss-of-function 24554720, 21720365, 25712099 -CDK12 Deletion Likely Oncogenic Likely Loss-of-function 24554720, 25712099, 24240700 -CDK12 Y901C Likely Oncogenic Loss-of-function 24554720, 21720365, 25712099 -CDK12 G909R Likely Oncogenic Loss-of-function 24554720, 25712099 -CDK12 D887N Likely Oncogenic Likely Loss-of-function 24554720 -CDK12 K975E Likely Neutral Likely Neutral 24554720, 21720365, 25712099 -AXL Amplification Likely Oncogenic Likely Gain-of-function 23264849, 22751098, 25337673, 25966280 -MYOD1 L122R Oncogenic Likely Gain-of-function 24793135, 1329087 -B2M M1R Likely Oncogenic Loss-of-function 22137796 -B2M M1V Likely Oncogenic Loss-of-function 24947018 -B2M M1T Likely Oncogenic Loss-of-function 22137796 -B2M Deletion Likely Oncogenic Likely Loss-of-function 25594174, 25294904, 22833104, 16730261, 22137796, 23784959, 9637706, 1898655 -B2M M1K Likely Oncogenic Loss-of-function 24947018, 22137796 -B2M M1I Likely Oncogenic Loss-of-function 11894933, 24947018 -B2M Truncating Mutations Likely Oncogenic Likely Loss-of-function 25594174, 25294904, 22833104, 16730261, 22137796, 23784959, 9637706, 1898655 -SRC Amplification Likely Oncogenic Likely Gain-of-function 24788409, 11114744, 15060621, 22589274 Zehir A et al. Nature Medicine, 2017 http://doi:10.1038/nm.4333 -SRC Q531* Likely Oncogenic Gain-of-function 9988270 -GATA3 Amplification Likely Oncogenic Likely Gain-of-function 20154722, 11441075, 18471881, 16087702, 24448324, 20855495, 21779441 -GATA3 R177Pfs*126 Likely Oncogenic Loss-of-function 26268891 -GATA3 Deletion Likely Oncogenic Likely Loss-of-function 10935639, 15361840, 23426732, 26637396, 24758297, 7829479 -GATA3 Truncating Mutations Likely Oncogenic Likely Loss-of-function 23426732, 18242514, 26637396, 27588951, 24758297 -BARD1 Truncating Mutations Likely Oncogenic Likely Loss-of-function -BARD1 Deletion Likely Oncogenic Likely Loss-of-function 20029420, 17848578, 20842729 -CCND1 256_286trunc Likely Oncogenic Gain-of-function 17299095, 9832503, 16732330, 9926916 -CCND1 C47S Likely Oncogenic Gain-of-function 24145436, 27713153 -CCND1 Y44D Likely Oncogenic Gain-of-function 24145436, 27713153 -CCND1 L283_D294del Likely Oncogenic Likely Gain-of-function 9832503, 16732330 -CCND1 T286A Oncogenic Gain-of-function 16732330, 11124803 -CCND1 D289del Oncogenic Gain-of-function 9832503, 16732330 -CCND1 P287S Likely Oncogenic Likely Gain-of-function 16732330, 12955092, 12615961 -CCND1 CCND1-IGH Fusion Likely Oncogenic Gain-of-function 14514791, 25596256, 16690963, 16402392 -CCND1 P287T Oncogenic Gain-of-function 9832503, 16732330, 12955092 -CCND1 P287A Likely Oncogenic Gain-of-function 16732330, 12615961 -CCND1 Amplification Oncogenic Gain-of-function 9832503, 20164920, 20074063, 8114739, 10508165, 11486031, 16393691, 9792703, 19020303, 21734724 -CCND1 Truncating Mutations Likely Oncogenic Likely Gain-of-function 28483394, 19823025 -CCND1 D289_D292del Likely Oncogenic Likely Gain-of-function 9832503, 16732330 -CCND1 T286I Oncogenic Gain-of-function 9832503, 16732330, 11124803 -BCL2 IGH-BCL2 Fusion Oncogenic Gain-of-function 23939148, 3500184, 18202696, 3874430, 10910891, 2875799, 23892979 -KEAP1 G480W Likely Oncogenic Likely Loss-of-function 24322982 -KEAP1 R272C Oncogenic Loss-of-function 18316592 -KEAP1 D422N Oncogenic Loss-of-function 24322982 -KEAP1 C23Y Likely Oncogenic Loss-of-function 17822677 -KEAP1 R470C Oncogenic Loss-of-function 24322982 -KEAP1 Deletion Likely Oncogenic Likely Loss-of-function 17020408, 24142871 -KEAP1 Truncating Mutations Likely Oncogenic Likely Loss-of-function 17020408, 24142871, 24322982 -KEAP1 G430C Oncogenic Loss-of-function 18316592 -KEAP1 R415G Oncogenic Loss-of-function 18316592 -KEAP1 R320Q Oncogenic Loss-of-function 24322982 -KEAP1 S243C Oncogenic Loss-of-function 24322982 -KEAP1 V155F Oncogenic Loss-of-function 24322982 -KEAP1 G333S Oncogenic Loss-of-function 23912815 -KEAP1 G423V Oncogenic Loss-of-function 24322982 -KEAP1 G333C Oncogenic Loss-of-function 19818716 -KEAP1 G186R Oncogenic Loss-of-function 24322982 -PTCH1 Truncating Mutations Likely Oncogenic Likely Loss-of-function 8782823 -PTCH1 R571W Likely Neutral Likely Neutral 24368541 -PTEN A126V Oncogenic Loss-of-function 21828076 -PTEN M199del Oncogenic Loss-of-function 11051241 -PTEN G129A Likely Oncogenic Likely Loss-of-function 21828076, 26619011 -PTEN G127N Oncogenic Loss-of-function 21828076 -PTEN G165R Likely Oncogenic Loss-of-function 10866302 -PTEN R173H Oncogenic Loss-of-function 10866302, 24721394 -PTEN G127E Oncogenic Loss-of-function 21828076 -PTEN S170R Oncogenic Loss-of-function 9467011, 10866302 -PTEN G165V Oncogenic Loss-of-function 9467011, 21828076 -PTEN H93Q Oncogenic Loss-of-function 21828076 -PTEN F154L Oncogenic Loss-of-function 19329485 -PTEN D92G Oncogenic Loss-of-function 21828076 -PTEN R130A Oncogenic Loss-of-function 21828076 -PTEN L108P Likely Oncogenic Loss-of-function 25527629 -PTEN A34D Oncogenic Loss-of-function 21828076 -PTEN A126G Oncogenic Loss-of-function 21828076 -PTEN K125E Oncogenic Loss-of-function 20926450, 21828076 -PTEN M35R Oncogenic Loss-of-function 21828076 -PTEN D162G Oncogenic Loss-of-function 21828076 -PTEN K125R Likely Neutral Neutral 21828076 -PTEN D24N Likely Oncogenic Likely Loss-of-function 17213812 -PTEN L112R Oncogenic Loss-of-function 10866302 -PTEN K125L Oncogenic Loss-of-function 21828076 -PTEN H123Q Oncogenic Loss-of-function 21828076 -PTEN I122L Oncogenic Loss-of-function 21828076 -PTEN R335L Oncogenic Loss-of-function 21828076 -PTEN C124R Oncogenic Loss-of-function 9467011, 21828076, 10866302 -PTEN R130* Oncogenic Loss-of-function 24721394 -PTEN T401I Likely Oncogenic Loss-of-function 10866302 -PTEN H93R Oncogenic Loss-of-function 21828076 -PTEN T319del Oncogenic Loss-of-function 10468583 -PTEN F341V Oncogenic Loss-of-function 11051241, 10866302 -PTEN C105F Likely Oncogenic Loss-of-function 10866302 -PTEN G251C Likely Oncogenic Loss-of-function 10866302 -PTEN S227F Likely Oncogenic Loss-of-function 10866302 -PTEN D92N Likely Oncogenic Loss-of-function 21828076 -PTEN L23F Oncogenic Loss-of-function 17213812 -PTEN R159G Likely Oncogenic Loss-of-function 17942903 -PTEN T131L Oncogenic Loss-of-function 21828076 -PTEN F347L Oncogenic Loss-of-function 10866302 -PTEN K342N Likely Oncogenic Loss-of-function 10866302 -PTEN I122V Likely Neutral Neutral 21828076 -PTEN A39P Oncogenic Loss-of-function 25527629 -PTEN G20E Likely Oncogenic Loss-of-function 17213812, 10866302 -PTEN L112P Oncogenic Loss-of-function 25527629, 10866302 -PTEN Y65C Oncogenic Loss-of-function 20926450, 19457929 -PTEN D24Y Oncogenic Loss-of-function 17213812 -PTEN L345Q Likely Oncogenic Loss-of-function 10866302 -PTEN Y27S Likely Oncogenic Loss-of-function 10866302 -PTEN A126S Oncogenic Loss-of-function 21828076 -PTEN V217D Oncogenic Loss-of-function 21828076 -PTEN R15S Oncogenic Gain-of-function 17213812 -PTEN R335* Oncogenic Loss-of-function 23475934 -PTEN R15K Oncogenic Loss-of-function 21828076 -PTEN P96Q Oncogenic Loss-of-function 21828076 -PTEN M134L Likely Oncogenic Loss-of-function 10866302 -PTEN G129R Oncogenic Loss-of-function 21828076, 25527629, 10866302, 9811831 -PTEN D92H Oncogenic Loss-of-function 21828076 -PTEN R130G Oncogenic Loss-of-function 21828076, 25527629, 11051241, 10866302, 9811831 -PTEN H93Y Oncogenic Loss-of-function 21828076, 10866302 -PTEN C124S Likely Oncogenic Loss-of-function 25527629, 9811831 -PTEN D92V Oncogenic Loss-of-function 21828076 -PTEN D162H Oncogenic Loss-of-function 23840064 -PTEN G129E Oncogenic Loss-of-function 9467011, 21828076, 25527629, 10866302, 9811831 -PTEN K62R Oncogenic Loss-of-function 20926450, 19457929 -PTEN R161G Oncogenic Loss-of-function 21828076 -PTEN T167A Oncogenic Loss-of-function 21828076 -PTEN D252G Oncogenic Loss-of-function 25527629 -PTEN A121V Likely Neutral Neutral 21828076 -PTEN A121P Likely Oncogenic Loss-of-function 10866302 -PTEN R130K Oncogenic Loss-of-function 21828076 -PTEN F241S Oncogenic Loss-of-function 21828076, 25527629 -PTEN K125M Oncogenic Loss-of-function 21828076 -PTEN H61R Likely Oncogenic Loss-of-function 10866302 -PTEN Y68H Likely Oncogenic Loss-of-function 23840064, 9467011, 10866302 -PTEN G36R Oncogenic Loss-of-function 21828076 -PTEN Y68D Oncogenic Loss-of-function 21828076 -PTEN F21A Likely Oncogenic Loss-of-function 17213812 -PTEN H123D Oncogenic Loss-of-function 21828076 -PTEN I32del Likely Oncogenic Loss-of-function 24904117, 10560660, 22817889, 9326929, 24293293 -PTEN V343L Oncogenic Loss-of-function 21828076 -PTEN S362L Likely Neutral Likely Neutral 19329485 -PTEN T131S Likely Neutral Neutral 21828076 -PTEN D331G Likely Oncogenic Loss-of-function 10866302 -PTEN E157G Oncogenic Loss-of-function 21828076 -PTEN N94I Oncogenic Loss-of-function 21828076 -PTEN V343E Oncogenic Loss-of-function 10866302 -PTEN Y155C Oncogenic Loss-of-function 21828076, 11051241, 10866302 -PTEN H61D Oncogenic Loss-of-function 21828076 -PTEN N48K Oncogenic Loss-of-function 21828076, 25527629 -PTEN V133I Likely Oncogenic Loss-of-function 10866302 -PTEN C136R Likely Oncogenic Loss-of-function 23475934 -PTEN G165E Oncogenic Loss-of-function 21828076 -PTEN Q110R Likely Neutral Likely Neutral 19329485 -PTEN R130Q Likely Oncogenic Loss-of-function 10866302 -PTEN G129D Oncogenic Loss-of-function 21828076 -PTEN A121E Oncogenic Loss-of-function 21828076 -PTEN Truncating Mutations Likely Oncogenic Likely Loss-of-function 17218262, 11237521 -PTEN S10N Likely Oncogenic Loss-of-function 10866302 -PTEN N276S Likely Oncogenic Loss-of-function 25527629 -PTEN A126D Oncogenic Loss-of-function 21828076 -PTEN I122S Oncogenic Loss-of-function 21828076 -PTEN K289E Likely Oncogenic Loss-of-function 10866302 -PTEN I168F Oncogenic Loss-of-function 21828076 -PTEN D92E Oncogenic Loss-of-function 21828076 -PTEN R173P Likely Oncogenic Loss-of-function 10866302 -PTEN T160I Oncogenic Loss-of-function 21828076 -PTEN Y174N Likely Oncogenic Loss-of-function 10866302 -PTEN I33del Likely Oncogenic Loss-of-function 24904117, 10560660, 22817889, 9326929, 24293293 -PTEN S170N Likely Oncogenic Loss-of-function 10866302 -PTEN H118P Oncogenic Loss-of-function 21828076, 25527629 -PTEN K128R Oncogenic Loss-of-function 21828076 -PTEN D107Y Likely Oncogenic Loss-of-function 10866302 -PTEN P95L Oncogenic Loss-of-function 21828076 -PTEN C136Y Oncogenic Loss-of-function 10866302 -PTEN L325F Oncogenic Loss-of-function 19329485 -PTEN G44D Oncogenic Loss-of-function 21828076 -PTEN K128N Oncogenic Loss-of-function 21828076 -PTEN K128Q Oncogenic Loss-of-function 25447541 -PTEN D92A Oncogenic Loss-of-function 21828076 -PTEN P169H Oncogenic Loss-of-function 21828076 -PTEN H123Y Oncogenic Loss-of-function 21828076 -PTEN V369G Likely Neutral Neutral 21828076, 10866302 -PTEN Y16C Likely Oncogenic Loss-of-function 10866302 -PTEN D326N Oncogenic Loss-of-function 21828076, 25527629 -PTEN T319A Likely Oncogenic Likely Loss-of-function 26166433 -PTEN R173C Likely Oncogenic Loss-of-function 10866302 -PTEN L42R Likely Oncogenic Loss-of-function 10866302 -PTEN Deletion Oncogenic Loss-of-function 12844284, 9697695, 12370746, 21430697 -PTEN C124N Oncogenic Loss-of-function 21828076 -PTEN H93D Oncogenic Loss-of-function 21828076 -PTEN K128T Oncogenic Loss-of-function 21828076 -PTEN D301N Likely Neutral Likely Neutral 19329485 -PTEN P95S Oncogenic Loss-of-function 19329485 -PTEN T131A Oncogenic Loss-of-function 21828076 -PTEN L181P Oncogenic Loss-of-function 21828076 -PTEN T131I Oncogenic Loss-of-function 21828076 -PTEN P38L Likely Oncogenic Likely Loss-of-function 23039341 -PTEN C71Y Oncogenic Loss-of-function 11051241, 10866302 -PTEN R130L Oncogenic Loss-of-function 9467011, 25527629, 10866302 -BCOR Deletion Likely Oncogenic Likely Loss-of-function 26847029, 10582652, 2212066 -BCOR BCOR-CCNB3 Fusion Oncogenic Likely Switch-of-function 22387997 -BCOR BCOR-RARA Fusion Oncogenic Likely Switch-of-function 20807888 -BCOR ZC3H7B-BCOR Fusion Oncogenic Likely Switch-of-function 23580382 -BCOR Truncating Mutations Likely Oncogenic Likely Loss-of-function 26847029, 25550361, 22237022, 22012066, 24047651 -BCOR Fusions Likely Oncogenic Likely Switch-of-function 24515802 -RNF43 Truncating Mutations Likely Oncogenic Likely Loss-of-function 23847203, 23096461, 25344691 -CIC Fusions Likely Oncogenic Likely Loss-of-function 22072439, 25007147, 28188754 -CIC R201W Likely Oncogenic Likely Loss-of-function 22072542, 25193860 -CIC R1515H Likely Oncogenic Likely Loss-of-function 22072542, 25193860 -CIC Truncating Mutations Likely Oncogenic Likely Loss-of-function 22072542, 22588899, 21817013, 24117486, 24086756 -CIC CIC-DUX4 Fusion Oncogenic Switch-of-function 22072439, 16717057 -INPP4B Deletion Likely Oncogenic Likely Loss-of-function 25883023, 25428846, 19647222, 21127264 -INPP4B Truncating Mutations Likely Oncogenic Likely Loss-of-function 25428846, 19647222, 21127264 -STAT3 F384V Likely Oncogenic Likely Gain-of-function 22751495, 17881745, 17676033, 18602572, 26619011 -STAT3 D661Y Likely Oncogenic Gain-of-function 25586472 -STAT3 F384Y Likely Oncogenic Likely Gain-of-function 22751495, 17881745, 17676033, 18602572, 26619011 -STAT3 Y640F Oncogenic Gain-of-function 25586472, 25873174, 22591296 -STAT3 F384L Likely Oncogenic Likely Gain-of-function 22751495, 17881745, 17676033, 18602572, 26619011 -STAT3 S614R Likely Oncogenic Gain-of-function 25586472, 25709890 -STAT3 D661V Likely Oncogenic Gain-of-function 22591296 -STAT3 H410R Likely Oncogenic Gain-of-function 26419508 -WHSC1L1 Amplification Inconclusive Inconclusive 18757432, 24874471, 21664949 -PRDM1 P48R Likely Oncogenic Loss-of-function 21156281 -PRDM1 C569Y Likely Oncogenic Loss-of-function 21156281 -PRDM1 Truncating Mutations Likely Oncogenic Likely Loss-of-function 20651244, 27568520, 16424392, 21156281, 16492805 -PRDM1 Y149D Likely Oncogenic Loss-of-function 21156281 -PRDM1 P48T Likely Oncogenic Loss-of-function 21156281 -PRDM1 Deletion Likely Oncogenic Likely Loss-of-function 27568520, 16424392, 21156281, 16492805 -JAK1 V658F Oncogenic Gain-of-function 20868368, 19139102, 21393331 -JAK1 A634D Oncogenic Gain-of-function 19139102 -JAK1 L783F Oncogenic Gain-of-function 21393331 -JAK1 F958S Oncogenic Gain-of-function 21393331 -JAK1 R724H Oncogenic Gain-of-function 18362171 -JAK1 S729C Oncogenic Gain-of-function 23788652 -JAK1 K1026E Oncogenic Gain-of-function 20868368 -JAK1 S703I Oncogenic Gain-of-function 24825865, 23788652 -JAK1 F958C Oncogenic Gain-of-function 21393331 -JAK1 A723D Likely Oncogenic Gain-of-function 24735922 -JAK1 Truncating Mutations Likely Oncogenic Likely Loss-of-function 24154688 -JAK1 Y1035C Oncogenic Gain-of-function 20868368 -JAK1 G871E Likely Oncogenic Likely Loss-of-function 16474838 -JAK1 Y652H Likely Oncogenic Gain-of-function 21551237 -JAK1 R879C Oncogenic Gain-of-function 18362171 -JAK1 G1079D Likely Oncogenic Gain-of-function 25873174 -JAK1 K648N Likely Oncogenic Gain-of-function 21551237 -JAK1 L910P Oncogenic Gain-of-function 20868368, 25873174, 23788652 -JAK1 F958V Oncogenic Gain-of-function 21393331 -JAK1 S646F Oncogenic Gain-of-function 19470474 -JAK2 V617F Oncogenic Gain-of-function 12351625, 15793561, 21533163, 19543316 -JAK2 R277K Inconclusive Inconclusive 26419724 -JAK2 Y931C Inconclusive Inconclusive 26419724 -JAK2 K539L Oncogenic Gain-of-function 20585391, 17267906, 21362419 -JAK2 C618R Oncogenic Gain-of-function 22960131 -JAK2 SPAG9-JAK2 Fusion Likely Oncogenic Likely Gain-of-function 25515960, 25951811 -JAK2 I1018W Inconclusive Inconclusive 26419724 -JAK2 G417P Inconclusive Inconclusive 26419724 -JAK2 TEL-JAK2 Fusion Oncogenic Gain-of-function 22733019, 10706877, 9360930, 15676212, 10845925 -JAK2 Fusions Likely Oncogenic Likely Gain-of-function 25207766, 24913195 -JAK2 S1025C Inconclusive Inconclusive 26419724 -JAK2 PAX5-JAK2 Fusion Oncogenic Gain-of-function 25207766, 25515960 -JAK2 Amplification Oncogenic Gain-of-function 20628145 -JAK2 S1039F Inconclusive Inconclusive 26419724 -JAK2 R683K Oncogenic Gain-of-function 18805579, 23748007, 23452118 -JAK2 W1038C Inconclusive Inconclusive 26419724 -JAK2 ATF7IP-JAK2 Fusion Oncogenic Gain-of-function 25207766 -JAK2 N542_E543del Oncogenic Gain-of-function 17267906 -JAK2 R683G Oncogenic Gain-of-function 18805579, 20585391, 23748007, 23452118 -JAK2 D544H Inconclusive Inconclusive 26419724 -JAK2 L1026F Inconclusive Inconclusive 26419724 -JAK2 Y1045* Inconclusive Inconclusive 26419724 -JAK2 I1018F Inconclusive Inconclusive 26419724 -JAK2 F1061W Inconclusive Inconclusive 26419724 -JAK2 F537_K539delinsL Oncogenic Gain-of-function 17267906 -JAK2 BCR-JAK2 Fusion Oncogenic Gain-of-function 25664618, 22549126, 22384256, 25789185, 23904814, 18537978, 16001431, 24913195, 18503828 -JAK2 SSBP2-JAK2 Fusion Likely Oncogenic Likely Gain-of-function 21325169, 18618714 -JAK2 L611V Likely Oncogenic Likely Gain-of-function 20182460 -JAK2 L551P Inconclusive Inconclusive 26419724 -JAK2 H538Q Oncogenic Gain-of-function 17267906 -JAK2 R683T Inconclusive Inconclusive 26419724 -JAK2 V1075F Inconclusive Inconclusive 26419724 -JAK2 R683S Oncogenic Gain-of-function 18805579, 23748007, 23452118 -JAK2 Y1045W Inconclusive Inconclusive 26419724 -JAK2 L983F Inconclusive Inconclusive 26419724 -JAK2 PCM1-JAK2 Fusion Likely Oncogenic Gain-of-function 16034466, 21325169, 23372669, 15805263, 16424865, 24913195 -JAK2 T875N Oncogenic Gain-of-function 20585391, 16804112, 19543316, 21362419 -AURKA F31I Likely Oncogenic Gain-of-function 12881723, 12208850 -AURKA K162D Likely Neutral Loss-of-function 12237287, 25395580 -AURKA Amplification Oncogenic Gain-of-function 9606188, 9771714, 10914715 -STK11 Deletion Likely Oncogenic Likely Loss-of-function 16582077, 21532627, 1627113, 19892943 -STK11 K78I Likely Oncogenic Loss-of-function 9837816 -STK11 W308C Likely Oncogenic Loss-of-function 9837816, 15987703 -STK11 Truncating Mutations Likely Oncogenic Likely Loss-of-function 24652667, 21516316, 19340305, 19892943, 25079552 -STK11 H174R Likely Oncogenic Loss-of-function 25960268 -STK11 D194Y Likely Oncogenic Loss-of-function 26917230 -STK11 F354L Likely Neutral Likely Neutral 15800014, 10676634 -STK11 G163D Likely Oncogenic Loss-of-function 9887330, 14668798, 10430928, 9605748 -STK11 R304W Oncogenic Loss-of-function 9837816, 12552571 -STK11 K78A Likely Oncogenic Loss-of-function 15800014, 14668798 -STK11 A205T Oncogenic Loss-of-function 16407837 -STK11 M136R Likely Oncogenic Loss-of-function 14668798 -STK11 D176N Likely Oncogenic Loss-of-function 9837816, 15987703 -STK11 I177N Oncogenic Loss-of-function 12552571 -STK11 L67P Likely Oncogenic Loss-of-function 9837816, 15987703 -JUN Amplification Oncogenic Gain-of-function 19449367, 17418412 -PTPN11 Q79R Likely Oncogenic Likely Gain-of-function 15834506 -PTPN11 E76K Oncogenic Gain-of-function 15834506, 12717436 -PTPN11 Y62C Likely Oncogenic Gain-of-function 15604238 -PTPN11 G464A Inconclusive Inconclusive 24935154 -PTPN11 P491S Likely Oncogenic Likely Gain-of-function 24891296 -PTPN11 D106A Oncogenic Gain-of-function 18286234 -PTPN11 E76A Oncogenic Gain-of-function 15834506, 12717436 -PTPN11 R498L Inconclusive Inconclusive 24935154 -PTPN11 K590R Likely Neutral Likely Switch-of-function 25823821 -PTPN11 A72V Oncogenic Gain-of-function 15834506 -PTPN11 R498W Likely Oncogenic Likely Loss-of-function 17053061, 24891296 -PTPN11 Deletion Oncogenic Loss-of-function 22869052 -PTPN11 Q510E Likely Oncogenic Likely Loss-of-function 25359717, 21803945, 22058153 -PTPN11 T73I Oncogenic Gain-of-function 15834506 -PTPN11 E139D Likely Oncogenic Likely Gain-of-function 16358218 -PTPN11 V45L Likely Oncogenic Gain-of-function 15604238 -PTPN11 Y63C Likely Oncogenic Gain-of-function 15834506 -PTPN11 I282V Oncogenic Gain-of-function 14974085, 15834506 -PTPN11 T507K Oncogenic Gain-of-function 15604238, 18286234 -PTPN11 E69K Likely Oncogenic Likely Gain-of-function 15604238, 12717436 -PTPN11 D61Y Oncogenic Gain-of-function 15834506, 12717436 -PTPN11 F71I Oncogenic Gain-of-function 15834506 -PTPN11 D61N Oncogenic Gain-of-function 15834506 -PTPN11 A72S Oncogenic Gain-of-function 14974085 -PTPN11 G503V Likely Oncogenic Likely Gain-of-function 15834506 -PTPN11 M504V Oncogenic Gain-of-function 15834506 -PTPN11 T468M Oncogenic Loss-of-function 26742426, 16358218, 25288766 -PTPN11 S502T Likely Oncogenic Gain-of-function 15834506 -PTPN11 N308D Oncogenic Gain-of-function 14974085, 15834506, 12717436 -NF1 R1391S Likely Oncogenic Loss-of-function 8052307, 19573811, 24576830, 9003501, 12509763, 8563751, 7542586 -NF1 Truncating Mutations Likely Oncogenic Likely Loss-of-function 8052307, 26345759, 19573811, 8563751, 23913538, 7542586, 7655472, 10862084, 24576830, 23047742, 10543400, 12509763, 14722914 -NF1 R1276Q Likely Oncogenic Loss-of-function 8052307, 19573811, 24576830, 12509763, 8563751, 22807134, 7542586 -NF1 S1463F Likely Oncogenic Loss-of-function 8052307, 19573811, 24576830, 12509763, 8563751, 22807134, 7542586, 22108604 -NF1 E1356G Likely Oncogenic Loss-of-function 8052307, 19573811, 24576830, 12509763, 8563751, 22807134, 7542586 -NF1 T1324N Likely Oncogenic Loss-of-function 8052307, 19573811, 24576830, 12509763, 8563751, 22807134, 7542586 -NF1 Deletion Likely Oncogenic Loss-of-function 23460398, 8052307, 19573811, 24576830, 12509763, 8563751, 19767589, 7542586, 20513137 -NF1 L1301R Likely Oncogenic Loss-of-function 8052307, 19573811, 24576830, 12509763, 8563751, 22807134, 7542586 -NF1 K1436Q Likely Oncogenic Loss-of-function 8052307, 19573811, 24576830, 12509763, 8563751, 22807134, 7542586 -NF1 R1276P Oncogenic Loss-of-function 9302992, 9219684, 9668168 -NF1 Y489C Oncogenic Loss-of-function 11258625 -NF1 K1423E Oncogenic Loss-of-function 8052307, 19573811, 24576830, 12509763, 8563751, 1568247, 7542586 -NF1 R2450* Likely Oncogenic Likely Loss-of-function 23288408 -NF1 V1398D Likely Oncogenic Loss-of-function 8052307, 19573811, 24576830, 12509763, 8563751, 22807134, 7542586 -NF1 R1204W Likely Oncogenic Loss-of-function 8052307, 19573811, 24576830, 12509763, 8563751, 22807134, 7542586 -NF1 R1391G Likely Oncogenic Loss-of-function 8052307, 19573811, 24576830, 12509763, 8563751, 22807134, 7542586 -NF1 R1204G Likely Oncogenic Loss-of-function 8052307, 19573811, 24576830, 12509763, 8563751, 22807134, 7542586 -FOXL2 Amplification Inconclusive Inconclusive 21623383 -FOXL2 C134W Likely Oncogenic Loss-of-function 24342437, 24817949, 23372819 -PTPRD Deletion Oncogenic Loss-of-function 19478061, 19074898, 26267899 -PTPRD G446E Likely Oncogenic Likely Loss-of-function 19074898, 25113440, 8393854 -PTPRD P1311T Likely Oncogenic Likely Loss-of-function 19478061, 26267899 -PTPRD Truncating Mutations Likely Oncogenic Likely Loss-of-function 19478061, 25113440 -PTPRD V1565I Likely Oncogenic Likely Loss-of-function 19074898 -PTPRD R1088C Likely Oncogenic Likely Loss-of-function 19478061 -BRCA1 E1682K Likely Neutral Likely Neutral 20516115 -BRCA1 C44F Likely Oncogenic Loss-of-function 20103620, 22034435, 23161852, 16403807 -BRCA1 E1282V Likely Neutral Likely Neutral 23867111 -BRCA1 S1715C Likely Oncogenic Likely Loss-of-function 20516115 -BRCA1 K56N Inconclusive Inconclusive 22034435, 16403807 -BRCA1 V1810G Likely Oncogenic Likely Loss-of-function 15004537, 15172985, 20516115 -BRCA1 R1589P Likely Neutral Likely Neutral 23867111 -BRCA1 I124V Inconclusive Inconclusive 23161852 -BRCA1 A1843T Likely Oncogenic Likely Loss-of-function 15172985, 11573086, 12496477 -BRCA1 H1746Q Inconclusive Inconclusive 23867111 -BRCA1 G1770V Likely Oncogenic Loss-of-function 23867111, 23613828 -BRCA1 I1766S Likely Oncogenic Loss-of-function 18680205, 20516115, 17308087 -BRCA1 Q1756fs Oncogenic Loss-of-function 14729053, 23867111, 27454287, 15569676, 9145676, 14576434 -BRCA1 I68K Inconclusive Inconclusive 22034435, 16403807 -BRCA1 E1250K Likely Neutral Likely Neutral 23867111 -BRCA1 W1718C Likely Oncogenic Loss-of-function 15172985, 23867111, 9799248, 20516115 -BRCA1 L1780P Likely Oncogenic Loss-of-function 15172985, 10811118, 20516115 -BRCA1 M1775R Oncogenic Loss-of-function 15004537, 14729053, 10811118, 12427738, 7545954, 8751436, 16101277, 11573086, 15689452, 15569676, 8942979, 10635334, 23161852, 15133502, 7939630, 15172985, 20516115, 21922593, 9159158 -BRCA1 G1788V Likely Oncogenic Loss-of-function 15004537, 15172985, 9796975, 15689452, 20516115 -BRCA1 L1267S Likely Neutral Likely Neutral 23867111 -BRCA1 S1651F Likely Neutral Neutral 23867111, 20516115 -BRCA1 R841Q Likely Neutral Likely Neutral 23867111 -BRCA1 S1101N Likely Neutral Likely Neutral 23867111 -BRCA1 E1836K Likely Oncogenic Likely Loss-of-function 20516115 -BRCA1 I90T Inconclusive Inconclusive 23161852 -BRCA1 F1662S Likely Neutral Likely Neutral 20516115 -BRCA1 S1164I Likely Oncogenic Likely Loss-of-function 18680205 -BRCA1 I42V Likely Neutral Neutral 20103620, 23161852 -BRCA1 A1752V Likely Oncogenic Likely Loss-of-function 20516115 -BRCA1 E33A Likely Oncogenic Likely Loss-of-function 21922593 -BRCA1 D1778Y Likely Neutral Likely Neutral 20516115 -BRCA1 P1856S Likely Neutral Likely Neutral 20516115 -BRCA1 A1830T Likely Neutral Likely Neutral 20516115 -BRCA1 C1697R Likely Oncogenic Loss-of-function 15172985, 20516115, 11157798 -BRCA1 K45T Inconclusive Inconclusive 22034435, 16403807 -BRCA1 T1720A Likely Neutral Likely Neutral 15004537, 15172985, 23867111, 15689452, 20516115 -BRCA1 N1819Y Inconclusive Inconclusive 15004537 -BRCA1 E1644G Likely Neutral Likely Neutral 17308087 -BRCA1 H1686Q Likely Oncogenic Loss-of-function 15172985, 23867111, 12496477 -BRCA1 P1637L Likely Neutral Likely Neutral 9159158 -BRCA1 F1761I Likely Oncogenic Likely Loss-of-function 15172985, 10811118 -BRCA1 P798L Likely Neutral Likely Neutral 23867111 -BRCA1 S153R Likely Neutral Neutral 23161852 -BRCA1 E143K Likely Neutral Likely Neutral 23161852 -BRCA1 W1837R Likely Oncogenic Loss-of-function 15172985, 23867111, 9799248, 8968102, 15689452, 20516115 -BRCA1 M1652K Likely Oncogenic Likely Loss-of-function 15004537, 15172985, 10811118 -BRCA1 R1699W Oncogenic Loss-of-function 15172985, 23867111, 11573086, 12496476, 20516115, 11157798, 7939630 -BRCA1 V1378I Likely Neutral Likely Neutral 23867111 -BRCA1 V1838E Likely Oncogenic Likely Loss-of-function 20516115 -BRCA1 H1421Y Likely Neutral Likely Neutral 15689452 -BRCA1 Y179C Inconclusive Inconclusive 18680205, 23161852 -BRCA1 P1806A Likely Neutral Likely Neutral 15004537, 15172985, 10811118, 20516115, 17308087 -BRCA1 P1776S Inconclusive Inconclusive 15172985, 10196379 -BRCA1 S59R Inconclusive Inconclusive 22034435, 16403807 -BRCA1 P1614S Likely Neutral Likely Neutral 17308087 -BRCA1 I89T Inconclusive Inconclusive 22034435, 16403807 -BRCA1 C39Y Oncogenic Loss-of-function 20103620, 22034435, 23161852, 21922593, 16403807 -BRCA1 L1854P Likely Oncogenic Likely Loss-of-function 20516115 -BRCA1 W1837C Likely Oncogenic Likely Loss-of-function 20516115 -BRCA1 T1773I Likely Oncogenic Likely Loss-of-function 20516115 -BRCA1 R1589H Likely Neutral Likely Neutral 23613828 -BRCA1 K45Q Likely Neutral Likely Neutral 23867111 -BRCA1 E60L Inconclusive Inconclusive 22034435, 16403807 -BRCA1 L1407P Likely Oncogenic Likely Loss-of-function 23867111, 19369211, 15689452, 16793542, 15770685 -BRCA1 S1715R Likely Oncogenic Loss-of-function 15172985, 20516115, 11157798 -BRCA1 S1841N Likely Oncogenic Likely Loss-of-function 15172985, 9799248, 20516115 -BRCA1 S1301R Likely Neutral Likely Neutral 23867111 -BRCA1 E29V Inconclusive Inconclusive 22034435, 16403807 -BRCA1 V1736G Likely Oncogenic Likely Loss-of-function 20516115 -BRCA1 I31M Likely Neutral Neutral 20103620, 23161852, 16403807 -BRCA1 T37R Likely Oncogenic Loss-of-function 20103620, 22034435, 23161852, 16403807 -BRCA1 P1856T Inconclusive Inconclusive 15172985 -BRCA1 C64G Likely Oncogenic Loss-of-function 20103620, 23867111, 22034435, 10635334, 23161852, 16403807 -BRCA1 R71G Inconclusive Inconclusive 20103620, 11385711, 23161852 -BRCA1 K50L Inconclusive Inconclusive 22034435, 16403807 -BRCA1 G1706A Likely Neutral Neutral 15172985, 23867111, 15689452, 15923272, 20516115 -BRCA1 K1702E Likely Oncogenic Likely Loss-of-function 15172985, 10811118 -BRCA1 R496C Likely Neutral Likely Neutral 18036263, 18497862 -BRCA1 S4F Inconclusive Inconclusive 23867111 -BRCA1 L246V Likely Neutral Likely Neutral 23867111 -BRCA1 K45N Inconclusive Inconclusive 22034435, 16403807 -BRCA1 C24Y Inconclusive Inconclusive 22034435, 16403807 -BRCA1 N1730S Likely Neutral Likely Neutral 15172985, 20516115 -BRCA1 Y1703S Likely Oncogenic Likely Loss-of-function 23613828 -BRCA1 R1751P Likely Oncogenic Likely Loss-of-function 15172985, 20516115 -BRCA1 V1653M Likely Oncogenic Likely Loss-of-function 15004537, 15172985, 20516115 -BRCA1 E1060A Likely Neutral Likely Neutral 23867111 -BRCA1 S308A Inconclusive Inconclusive 23867111 -BRCA1 C61G Likely Oncogenic Loss-of-function 14729053, 20103620, 23867111, 22034435, 15569676, 23161852, 16403807 -BRCA1 K1487R Likely Oncogenic Likely Loss-of-function 18992264 -BRCA1 C24R Likely Oncogenic Loss-of-function 20103620, 23161852 -BRCA1 S4P Inconclusive Inconclusive 22034435, 16403807 -BRCA1 M1783L Likely Neutral Likely Neutral 20516115 -BRCA1 V271L Likely Neutral Neutral 23867111 -BRCA1 A1823T Likely Neutral Likely Neutral 15172985, 12142080, 20516115 -BRCA1 T1691K Likely Oncogenic Likely Loss-of-function 20516115 -BRCA1 A1752G Likely Neutral Likely Neutral 23842040 -BRCA1 H1402Y Likely Neutral Likely Neutral 15689452 -BRCA1 D1778H Inconclusive Inconclusive 15172985, 9809041 -BRCA1 L165P Likely Neutral Likely Neutral 23867111 -BRCA1 V1804A Inconclusive Inconclusive 15004537 -BRCA1 W1718S Likely Oncogenic Likely Loss-of-function 15172985, 20516115 -BRCA1 R133H Likely Neutral Neutral 23161852 -BRCA1 T1773S Likely Neutral Likely Neutral 15172985, 20516115 -BRCA1 D1692H Likely Oncogenic Likely Loss-of-function 20516115 -BRCA1 D1692Y Likely Oncogenic Likely Loss-of-function 15172985, 20516115 -BRCA1 D695N Likely Neutral Likely Neutral 23867111 -BRCA1 L1657P Likely Oncogenic Likely Loss-of-function 15172985, 12496477 -BRCA1 R866C Likely Neutral Likely Neutral 23867111 -BRCA1 G57R Inconclusive Inconclusive 22034435, 16403807 -BRCA1 A1708V Likely Oncogenic Likely Loss-of-function 20516115 -BRCA1 H1805P Likely Neutral Likely Neutral 20516115 -BRCA1 N1819S Likely Neutral Likely Neutral 15172985, 20516115 -BRCA1 V191D Likely Neutral Likely Neutral 23161852 -BRCA1 G1656D Likely Oncogenic Likely Loss-of-function 20516115 -BRCA1 I89N Inconclusive Inconclusive 22034435, 16403807 -BRCA1 K50E Inconclusive Inconclusive 22034435, 16403807 -BRCA1 A1789S Likely Neutral Likely Neutral 20516115 -BRCA1 M1008I Likely Neutral Likely Neutral 23867111 -BRCA1 A1752P Likely Oncogenic Loss-of-function 15172985, 15689452, 20516115 -BRCA1 K65M Inconclusive Inconclusive 22034435, 16403807 -BRCA1 V1804D Inconclusive Inconclusive 15004537, 15172985, 23867111, 15350310, 20516115, 17308087 -BRCA1 D1778N Likely Neutral Likely Neutral 15172985, 20516115 -BRCA1 R1753T Likely Oncogenic Loss-of-function 23867111, 20516115, 17308087 -BRCA1 R1758G Inconclusive Inconclusive 15172985, 9544765 -BRCA1 L1844R Likely Neutral Likely Neutral 20516115 -BRCA1 Truncating Mutations Likely Oncogenic Likely Loss-of-function 12483515, 11358863, 20608970, 12947386 -BRCA1 V191I Likely Neutral Likely Neutral 23867111 -BRCA1 Y1703H Likely Oncogenic Likely Loss-of-function 15172985, 10811118, 11573086 -BRCA1 V1713A Oncogenic Loss-of-function 20516115, 17308087, 9159158 -BRCA1 S1613C Likely Neutral Likely Neutral 18992264 -BRCA1 M1689T Likely Oncogenic Likely Loss-of-function 20516115 -BRCA1 C47G Likely Oncogenic Loss-of-function 20103620, 22034435, 23161852, 16403807 -BRCA1 T47D Likely Neutral Likely Neutral 15569676 -BRCA1 M1663L Likely Neutral Likely Neutral 20516115 -BRCA1 S1613G Likely Neutral Likely Neutral 9159158 -BRCA1 R170W Likely Neutral Likely Neutral 23867111 -BRCA1 F1695L Likely Neutral Likely Neutral 15172985, 17161371, 20516115 -BRCA1 L63F Inconclusive Inconclusive 22034435, 16403807 -BRCA1 C44Y Oncogenic Loss-of-function 22034435, 21922593, 16403807 -BRCA1 C1767S Likely Neutral Likely Neutral 23867111 -BRCA1 T1691I Likely Oncogenic Likely Loss-of-function 23867111, 20516115 -BRCA1 F1704S Likely Oncogenic Likely Loss-of-function 15172985, 11573086, 12496477 -BRCA1 C360R Likely Neutral Likely Neutral 23867111 -BRCA1 E362H Likely Neutral Likely Neutral 23867111 -BRCA1 R170Q Likely Neutral Neutral 23161852 -BRCA1 M1411T Inconclusive Inconclusive 23867111, 19369211, 16793542, 15770685 -BRCA1 W1782C Likely Neutral Likely Neutral 23867111 -BRCA1 E1586G Likely Neutral Likely Neutral 23613828 -BRCA1 G1743R Likely Oncogenic Likely Loss-of-function 15172985, 12496477 -BRCA1 W1837G Likely Oncogenic Likely Loss-of-function 15172985, 9799248, 20516115 -BRCA1 G1706E Likely Oncogenic Loss-of-function 15172985, 23867111, 20516115, 17308087 -BRCA1 T1852S Inconclusive Inconclusive 15172985 -BRCA1 L358R Likely Neutral Likely Neutral 23867111 -BRCA1 S1448G Likely Neutral Likely Neutral 23867111 -BRCA1 G1763V Likely Oncogenic Likely Loss-of-function 20516115 -BRCA1 C39S Inconclusive Inconclusive 22034435, 16403807 -BRCA1 Q1826H Likely Neutral Likely Neutral 18992264, 20516115 -BRCA1 D1733G Likely Neutral Likely Neutral 15172985, 10811118, 17161371, 20516115, 11157798 -BRCA1 Deletion Likely Oncogenic Likely Loss-of-function 12483515, 18501021, 27452521, 12670888, 9354803 -BRCA1 L147F Likely Neutral Likely Neutral 23867111 -BRCA1 M1628V Likely Oncogenic Likely Loss-of-function 15689452 -BRCA1 M1400V Inconclusive Inconclusive 23867111, 19369211, 16793542, 15770685 -BRCA1 L82P Inconclusive Inconclusive 22034435, 16403807 -BRCA1 V1736A Likely Oncogenic Loss-of-function 15004537, 15172985, 23867111, 20516115, 17308087 -BRCA1 E1794D Likely Neutral Likely Neutral 23867111, 20516115, 17308087 -BRCA1 W1718L Likely Oncogenic Likely Loss-of-function 23613828 -BRCA1 S1715N Likely Oncogenic Loss-of-function 15172985, 20516115, 11157798 -BRCA1 M1783I Likely Neutral Likely Neutral 20516115 -BRCA1 L1564P Likely Oncogenic Likely Loss-of-function 17308087 -BRCA1 V1665M Likely Neutral Likely Neutral 15172985, 20516115, 11157798 -BRCA1 H41R Likely Oncogenic Loss-of-function 20103620, 22034435, 23161852, 16403807 -BRCA1 S1140G Likely Neutral Likely Neutral 23867111 -BRCA1 Y856H Likely Neutral Likely Neutral 23867111 -BRCA1 I26N Inconclusive Inconclusive 22034435, 16403807 -BRCA1 M1663K Likely Neutral Likely Neutral 20516115 -BRCA1 D1739E Likely Oncogenic Likely Loss-of-function 15004537, 15172985, 20516115 -BRCA1 T77M Inconclusive Inconclusive 22034435, 16403807 -BRCA1 R1699L Likely Oncogenic Likely Loss-of-function 15172985, 11573086, 20516115 -BRCA1 G1738R Likely Oncogenic Loss-of-function 15172985, 20516115, 17308087 -BRCA1 K1110del Likely Neutral Likely Neutral 23867111 -BRCA1 V1714G Likely Oncogenic Likely Loss-of-function 20516115 -BRCA1 N132K Likely Neutral Neutral 23867111, 18680205, 23161852 -BRCA1 R1751Q Likely Neutral Likely Neutral 9150149, 15172985, 20516115 -BRCA1 T826K Inconclusive Inconclusive 23867111, 10635334 -BRCA1 V1688del Likely Oncogenic Likely Loss-of-function 23867111 -BRCA1 D1818G Inconclusive Inconclusive 20516115 -BRCA1 Q1409L Likely Neutral Likely Neutral 23613828 -BRCA1 R1443G Likely Neutral Likely Neutral 23867111, 17308087 -BRCA1 P1859R Likely Neutral Likely Neutral 15172985, 20516115 -BRCA1 G1803A Likely Oncogenic Likely Loss-of-function 15172985, 20516115 -BRCA1 D1344H Inconclusive Inconclusive 25416589 -BRCA1 G1788D Likely Oncogenic Likely Loss-of-function 15172985, 20516115, 17308087 -BRCA1 C39R Inconclusive Inconclusive 22034435, 16403807 -BRCA1 R1699Q Likely Oncogenic Loss-of-function 15172985, 23867111, 11573086, 20516115, 11157798 -BRCA1 L52F Likely Neutral Neutral 20103620, 22034435, 23161852, 16403807 -BRCA1 H1862L Likely Neutral Likely Neutral 23867111 -BRCA1 D1739V Likely Oncogenic Loss-of-function 23867111, 20516115 -BRCA1 P142H Likely Neutral Neutral 23867111, 23161852 -BRCA1 Q12Y Inconclusive Inconclusive 22034435, 16403807 -BRCA1 Q1785H Likely Neutral Likely Neutral 20516115, 17308087 -BRCA1 S186Y Likely Neutral Neutral 23867111, 23161852 -BRCA1 T1685A Likely Oncogenic Likely Loss-of-function 15172985, 20516115 -BRCA1 K38N Inconclusive Inconclusive 22034435, 16403807 -BRCA1 I21V Likely Neutral Neutral 20103620, 23161852 -BRCA1 M1775V Likely Neutral Likely Neutral 15172985, 11573086, 8942979 -BRCA1 S1497A Likely Neutral Likely Neutral 23867111 -BRCA1 P1771L Likely Neutral Likely Neutral 15172985, 20516115 -BRCA1 C1787S Likely Neutral Likely Neutral 15172985, 11573086, 20516115 -BRCA1 N550H Likely Neutral Likely Neutral 18680205 -BRCA1 P1812S Inconclusive Inconclusive 15172985 -BRCA1 V1534M Likely Neutral Likely Neutral 23867111, 17308087 -BRCA1 A1708E Oncogenic Loss-of-function 15172985, 23867111, 8751436, 11573086, 15923272, 8942979, 20516115, 21922593, 11157798, 9159158, 7939630 -BRCA1 M1R Likely Oncogenic Likely Loss-of-function 21922593 -BRCA1 H1746N Likely Oncogenic Likely Loss-of-function 15172985, 20516115 -BRCA1 E1660G Likely Oncogenic Likely Loss-of-function 15172985, 12496477 -BRCA1 Y105C Likely Neutral Neutral 23867111, 23161852 -BRCA1 V1833E Likely Oncogenic Likely Loss-of-function 15172985, 10811118 -BRCA1 Q1756C Likely Oncogenic Likely Loss-of-function 8942979 -BRCA1 V1696L Likely Oncogenic Likely Loss-of-function 15172985, 20516115 -BRCA1 M1775E Likely Oncogenic Likely Loss-of-function 15172985, 11573086, 8942979 -BRCA1 D96N Inconclusive Inconclusive 22034435, 16403807 -BRCA1 D67Y Likely Neutral Neutral 20103620, 23867111, 23161852 -BRCA1 T1685I Likely Oncogenic Loss-of-function 15172985, 15689452, 20516115 -BRCA1 M18T Oncogenic Loss-of-function 20103620, 23867111, 23161852, 21922593 -BRCA1 S1655F Likely Oncogenic Loss-of-function 15004537, 23867111, 20516115, 17308087 -BRCA1 V1809F Likely Oncogenic Likely Loss-of-function 15172985, 15689452, 20516115 -BRCA1 S1651P Inconclusive Inconclusive 23867111 -BRCA1 T1700A Likely Oncogenic Loss-of-function 20516115, 17308087 -BRCA1 Y1853* Oncogenic Loss-of-function 15004537, 14729053, 8942979, 15569676, 21922593 -BRCA1 A1843P Likely Oncogenic Likely Loss-of-function 15172985, 11595708, 20516115 -BRCA1 I1807S Likely Oncogenic Likely Loss-of-function 15172985, 12496477 -BRCA1 M1775K Likely Oncogenic Loss-of-function 15172985, 18285836, 11573086, 8942979, 20516115 -BRCA1 M1689R Likely Oncogenic Likely Loss-of-function 15172985, 20516115 -BRCA1 L1664P Likely Neutral Likely Neutral 15172985, 20516115, 17308087 -BRCA1 D1692N Likely Neutral Likely Neutral 15172985, 10196379, 20516115, 11157798 -BRCA1 L28P Inconclusive Inconclusive 22034435, 16403807 -BRCA1 F1734S Likely Oncogenic Likely Loss-of-function 15172985, 20516115 -BRCA1 S72R Inconclusive Inconclusive 22034435, 16403807 -BRCA1 P1812R Likely Neutral Likely Neutral 23867111 -BRCA1 F1761S Likely Oncogenic Loss-of-function 15172985, 10811118, 20516115 -BRCA1 Y1853C Likely Oncogenic Loss-of-function 23842040, 20516115 -BRCA1 V1808A Likely Neutral Likely Neutral 15004537, 15172985, 20516115 -BRCA1 E23fs Oncogenic Loss-of-function 14729053, 23867111, 27454287, 27454289, 15569676, 9145676, 14576434 -BRCA1 H1686R Likely Oncogenic Likely Loss-of-function 23867111 -BRCA1 V1809A Likely Neutral Likely Neutral 15172985, 20516115 -BRCA1 V1833M Likely Oncogenic Likely Loss-of-function 15004537, 18992264, 15172985, 12142080, 20516115 -BRCA1 C27A Likely Oncogenic Loss-of-function 20103620, 23161852 -BRCA1 N1236K Likely Neutral Likely Neutral 23867111 -BRCA1 L1705P Likely Oncogenic Likely Loss-of-function 15172985, 10811118, 11573086 -BRCA1 M1652T Inconclusive Inconclusive 15004537, 15172985, 9585608, 20516115 -BRCA1 F79S Inconclusive Inconclusive 22034435, 16403807 -BRCA1 S1512I Likely Neutral Likely Neutral 18680205, 15689452 -BRCA1 M18K Inconclusive Inconclusive 22034435, 16403807 -BRCA1 F1734L Likely Oncogenic Likely Loss-of-function 15172985, 12496477 -BRCA1 E1214K Likely Neutral Likely Neutral 23867111 -BRCA1 S1486C Likely Neutral Likely Neutral 23867111 -BRCA1 S1473P Likely Neutral Likely Neutral 23613828 -BRCA1 R1726G Likely Neutral Likely Neutral 20516115 -BRCA1 D245V Likely Neutral Likely Neutral 23867111 -BRCA1 T231M Likely Neutral Likely Neutral 23867111 -BRCA1 A1669S Likely Neutral Likely Neutral 15172985, 20516115, 11157798 -BRCA1 N1647K Likely Neutral Likely Neutral 20516115 -BRCA1 S1841R Likely Oncogenic Likely Loss-of-function 20516115 -BRCA1 D1546N Inconclusive Inconclusive 17308087 -BRCA1 D1739G Likely Oncogenic Loss-of-function 15004537, 15172985, 23867111, 20516115 -BRCA1 V11A Inconclusive Inconclusive 18493658 -BRCA1 P1771R Likely Neutral Likely Neutral 20516115 -BRCA1 S1297del Likely Neutral Likely Neutral 23867111 -BRCA1 Q1811R Likely Oncogenic Likely Loss-of-function 15172985, 20516115 -BRCA1 L668F Likely Neutral Likely Neutral 23867111 -BRCA1 M1783T Inconclusive Inconclusive 15004537, 15172985, 20516115 -BRCA1 D1778G Likely Neutral Likely Neutral 15172985, 20516115 -BRCA1 N810Y Likely Neutral Likely Neutral 23867111 -BRCA1 P1749R Oncogenic Loss-of-function 14729053, 15172985, 8751436, 15569676, 10635334, 20516115, 21922593, 9159158 -BRCA1 V1741G Likely Oncogenic Likely Loss-of-function 12497638, 15172985, 20516115 -BRCA1 I15T Inconclusive Inconclusive 22034435, 16403807 -BRCA1 T1720I Likely Neutral Likely Neutral 15004537 -BRCA1 S1722F Likely Oncogenic Loss-of-function 15172985, 9799248, 10196379, 20516115 -BRCA1 D1739Y Likely Oncogenic Likely Loss-of-function 15172985, 20516115 -BRCA1 M1628T Likely Neutral Likely Neutral 23867111, 15350310, 15689452 -BRCA1 S988A Likely Neutral Likely Neutral 23867111 -BRCA1 M1652I Likely Neutral Likely Neutral 18992264, 15172985, 23867111, 9326340, 12215251, 9523200, 20516115, 21922593, 9159158 -BRCA1 S1841A Likely Oncogenic Likely Loss-of-function 21922593 -BRCA1 P1812A Likely Oncogenic Likely Loss-of-function 15172985, 17020472 -BRCA1 A1789T Oncogenic Loss-of-function 23867111, 18680205 -BRCA1 G1738E Likely Oncogenic Loss-of-function 15172985, 10811118, 20516115, 17308087, 11157798 -BRCA1 R1835P Likely Oncogenic Likely Loss-of-function 20516115 -BRCA1 D1851E Likely Neutral Likely Neutral 20516115 -BRCA1 L1764P Likely Oncogenic Loss-of-function 15172985, 23867111, 20516115, 17308087 -BRCA1 E1735K Inconclusive Inconclusive 15172985, 23867111, 9809041 -BRCA1 E1682V Likely Neutral Likely Neutral 20516115 -BRCA1 E1346K Likely Neutral Likely Neutral 23867111 -BRAF V600K Oncogenic Gain-of-function 16273091, 22663011, 12068308, 25265492, 24508103, 25287827, 25399551, 15035987 Planchard et al. Abstract# 8009, ASCO 2013 http://meetinglibrary.asco.org/content/112427-132 -BRAF K601Q Likely Oncogenic Gain-of-function 19206169 -BRAF D594A Likely Oncogenic Gain-of-function 14678966, 20141835, 15035987 -BRAF G469E Likely Oncogenic Likely Gain-of-function 15150094, 22510884, 15035987, 16439621 -BRAF V600_K601delinsE Oncogenic Gain-of-function 26045855, 23833300 -BRAF G478C Likely Neutral Loss-of-function 22926515 -BRAF FAM131B-BRAF Fusion Likely Oncogenic Gain-of-function 15630448, 21424530 -BRAF L597S Likely Oncogenic Likely Gain-of-function 22798288, 26643848 -BRAF G464R Likely Oncogenic Gain-of-function 15046639 -BRAF Q201H Inconclusive Inconclusive 18060073 -BRAF D594Y Likely Oncogenic Likely Gain-of-function 23833300, 20141835, 16439621 -BRAF L485_Q494del Likely Oncogenic Likely Gain-of-function 26732095 -BRAF A728V Likely Oncogenic Gain-of-function 15035987 -BRAF W531C Likely Neutral Likely Neutral 19206169 -BRAF T599I Likely Oncogenic Gain-of-function 15035987 -BRAF L485_P490delinsF Likely Oncogenic Likely Gain-of-function 26732095 -BRAF F595L Likely Oncogenic Gain-of-function 15150094, 15035987 -BRAF K601N Likely Oncogenic Gain-of-function 24270325, 26343582 -BRAF D594G Likely Oncogenic Likely Gain-of-function 23833300, 18794803, 20141835, 16439621 -BRAF L485_P490del Oncogenic Gain-of-function 26732095 -BRAF R671Q Likely Oncogenic Likely Gain-of-function 28174173 -BRAF G466R Likely Oncogenic Likely Gain-of-function 16364920, 15046639, 15035987 -BRAF D594E Likely Oncogenic Gain-of-function 20978199 Noeparast et al. Abstract# 11091, ASCO 2015 http://meeting.ascopubs.org/cgi/content/abstract/33/15_suppl/11091 -BRAF G596R Likely Oncogenic Gain-of-function 14678966, 16364920, 15035987 -BRAF T599_V600insEAT Likely Oncogenic Likely Gain-of-function 16501605 -BRAF T488_P492del Likely Oncogenic Likely Gain-of-function 26732095 -BRAF T599_V600insETT Likely Oncogenic Likely Gain-of-function 16501605 -BRAF L505H Oncogenic Gain-of-function 25515853, 24112705, 24283590 -BRAF T599insTT Oncogenic Gain-of-function 21190184 -BRAF D287H Likely Oncogenic Likely Gain-of-function 26343582 -BRAF I463S Likely Neutral Likely Neutral 15150094, 15035987 -BRAF K601E Likely Oncogenic Gain-of-function 22798288, 24583796, 24933606, 26643848, 23248257, 15035987 -BRAF D594V Likely Oncogenic Gain-of-function 14678966, 19376813, 15035987, 16439621 -BRAF K483M Likely Oncogenic Likely Gain-of-function 19376813, 23533272, 15035987, 27025703 -BRAF T599dup Oncogenic Gain-of-function 23833300, 21190184, 19363522 -BRAF G464E Likely Neutral Likely Neutral 15150094, 20141835, 15035987 -BRAF T529N Likely Neutral Likely Neutral 15573099, 20538618 -BRAF S467A Likely Oncogenic Gain-of-function 19376813, 16439621 -BRAF T599R Oncogenic Gain-of-function 25120313, 19206169 -BRAF V600M Oncogenic Gain-of-function 23463675, 16273091, 12068308, 15035987, 25382067 -BRAF L597R Likely Oncogenic Likely Gain-of-function 22798288, 26643848 -BRAF V600D_K601insFGLAT Oncogenic Gain-of-function 17297294 -BRAF S151A Likely Oncogenic Likely Gain-of-function 21478863 -BRAF N581S Likely Oncogenic Likely Gain-of-function 15035987 -BRAF R462I Likely Neutral Neutral 15150094, 15035987 -BRAF SND1-BRAF Fusion Oncogenic Gain-of-function 25266736, 25985019, 22745804, 24345920 -BRAF F468C Oncogenic Gain-of-function 15150094 -BRAF E501G Likely Neutral Likely Neutral 16474404, 16439621 -BRAF Y472C Likely Oncogenic Gain-of-function 22649091 -BRAF G469del Likely Oncogenic Likely Gain-of-function 23833300 -BRAF TRIM24-BRAF Fusion Likely Oncogenic Gain-of-function 15630448, 24345920 -BRAF p61BRAF Oncogenic Gain-of-function 22113612 -BRAF D594N Likely Oncogenic Gain-of-function 22798288 Noeparast et al. Abstract# 11091, ASCO 2015 http://meeting.ascopubs.org/cgi/content/abstract/33/15_suppl/11091 -BRAF Q257R Likely Oncogenic Gain-of-function 19376813, 16474404, 16439621 -BRAF V600D Oncogenic Gain-of-function 23317446, 20551065, 16273091, 12068308, 15035987 -BRAF A598V Likely Oncogenic Gain-of-function 19200582 -BRAF MKRN1-BRAF Fusion Likely Oncogenic Likely Gain-of-function 18974108, 26314551, 15630448, 23817572 -BRAF R506_K507insVLR Likely Oncogenic Gain-of-function 23817572 -BRAF L597Q Likely Oncogenic Gain-of-function 26343582, 22798288, 26643848 -BRAF L485F Likely Oncogenic Gain-of-function 16474404, 16439621 -BRAF G464V Oncogenic Gain-of-function 15150094, 12068308, 15035987 -BRAF KIAA1549-BRAF Fusion Oncogenic Gain-of-function 18974108, 23533272, 24345920 -BRAF V600R Oncogenic Gain-of-function 16273091, 12068308, 23473613, 15035987, 23490649 -BRAF L485_P490delinsY Likely Oncogenic Likely Gain-of-function 26732095 -BRAF AGK-BRAF Fusion Oncogenic Gain-of-function 26314551, 23890088, 24135138 -BRAF G469V Likely Oncogenic Likely Gain-of-function 25870796, 23401075 -BRAF G469R Likely Oncogenic Gain-of-function 26150740, 24920063, 16096377, 26343582, 26619011 -BRAF T529I Likely Neutral Likely Neutral 15573099, 20538618 -BRAF E275K Likely Oncogenic Likely Gain-of-function 19206169 -BRAF CUL1-BRAF Fusion Likely Oncogenic Likely Gain-of-function 25985019, 22745804, 15630448, 26324360 -BRAF Fusions Likely Oncogenic Likely Gain-of-function 18974108, 26314551, 25985019, 23890088, 22745804, 15630448, 26324360, 21424530, 24345920 -BRAF T599_V600insV Oncogenic Gain-of-function 16501605 -BRAF A598T Likely Neutral Loss-of-function 26619011, 22926515 -BRAF V600G Likely Oncogenic Gain-of-function 20735442, 16273091, 12068308, 26287849, 15035987 -BRAF G469L Likely Oncogenic Likely Gain-of-function 24920063, 24035431 -BRAF AKAP9-BRAF Fusion Oncogenic Gain-of-function 15630448 -BRAF A246P Likely Oncogenic Gain-of-function 16474404 -BRAF V487_P492delinsA Likely Oncogenic Likely Gain-of-function 26732095 -BRAF T241P Likely Oncogenic Likely Gain-of-function 19206169 -BRAF V471F Oncogenic Gain-of-function 25348715 -BRAF G596V Likely Oncogenic Likely Gain-of-function 19376813, 16439621 -BRAF PAPSS1-BRAF Fusion Likely Oncogenic Gain-of-function 15630448, 24345920 -BRAF E501K Inconclusive Inconclusive 17603482, 16474404 -BRAF N486_P490del Likely Oncogenic Likely Gain-of-function 26732095, 18060073 -BRAF G466A Likely Oncogenic Gain-of-function 17724477, 15035987 -BRAF P490_Q494del Likely Oncogenic Likely Gain-of-function 26732095 -BRAF R509H Likely Neutral Loss-of-function 20179705 -BRAF V600delinsYM Oncogenic Gain-of-function 22752848 -BRAF N581Y Likely Oncogenic Likely Gain-of-function 19474002, 26084293, 19276360, 15035987 -BRAF E586K Likely Oncogenic Gain-of-function 15035987 -BRAF L584F Inconclusive Inconclusive 23658559 -BRAF I326V Likely Neutral Likely Neutral 17603482 -BRAF N581D Likely Oncogenic Likely Gain-of-function 16474404 -BRAF K483E Likely Oncogenic Likely Gain-of-function 27799065, 23533272, 15035987 -BRAF K499E Likely Oncogenic Gain-of-function 16474404, 16439621 -BRAF R462E Likely Oncogenic Likely Gain-of-function 25155755 -BRAF G596C Likely Oncogenic Gain-of-function Noeparast et al. Abstract# 11091, ASCO 2015 http://meeting.ascopubs.org/cgi/content/abstract/33/15_suppl/11091 -BRAF Amplification Oncogenic Gain-of-function 15467732, 24055054, 25618114, 22395615, 21098728 -BRAF G469A Oncogenic Gain-of-function 23833300, 12068308, 22510884, 15035987, 22773810, 16439621 -BRAF V600E Oncogenic Gain-of-function 20179705, 16273091, 23153539, 12068308, 15035987 -BRAF T529M Likely Neutral Likely Neutral 15573099, 20538618 -BRAF L597V Oncogenic Gain-of-function 26343582, 12068308, 26643848, 15035987 -BRAF G466E Likely Oncogenic Gain-of-function 16364920, 15035987, 24446311 -BRAF G466V Likely Oncogenic Gain-of-function 22649091, 24202393, 16364920, 15035987, 16439621 -BRCA2 A2351G Inconclusive Inconclusive 18824701 -BRCA2 S2483N Inconclusive Inconclusive 18824701 -BRCA2 R2520Q Likely Neutral Likely Neutral 18451181 -BRCA2 I1349T Inconclusive Inconclusive 17924331 -BRCA2 K2729N Likely Neutral Likely Neutral 17924331, 18451181 -BRCA2 D806H Inconclusive Inconclusive 17924331 -BRCA2 T2515I Inconclusive Inconclusive 18375895 -BRCA2 K2472T Inconclusive Inconclusive 18375895 -BRCA2 A75P Inconclusive Inconclusive 17924331 -BRCA2 R2888C Inconclusive Inconclusive 17924331 -BRCA2 R2304C Inconclusive Inconclusive 18824701 -BRCA2 R3052W Likely Oncogenic Likely Loss-of-function 18451181 -BRCA2 N1102Y Inconclusive Inconclusive 17924331 -BRCA2 M784V Inconclusive Inconclusive 18824701 -BRCA2 R2418G Inconclusive Inconclusive 18824701 -BRCA2 N2113S Inconclusive Inconclusive 17924331 -BRCA2 K607T Inconclusive Inconclusive 18375895 -BRCA2 V1643A Inconclusive Inconclusive 18824701 -BRCA2 A2643G Likely Neutral Likely Neutral 18451181 -BRCA2 L929S Inconclusive Inconclusive 18824701 -BRCA2 S1670A Inconclusive Inconclusive 18375895 -BRCA2 R2659K Likely Oncogenic Loss-of-function 17924331, 18451181, 12624152 -BRCA2 R1190W Inconclusive Inconclusive 17924331 -BRCA2 T2681R Inconclusive Inconclusive 18824701 -BRCA2 E2856A Likely Neutral Likely Neutral 16489001, 18824701 -BRCA2 T2250A Inconclusive Inconclusive 17924331 -BRCA2 N372H Likely Neutral Likely Neutral 18451181 -BRCA2 S206C Likely Oncogenic Likely Loss-of-function 22962691 -BRCA2 N517S Inconclusive Inconclusive 18824701 -BRCA2 E2663V Likely Oncogenic Likely Loss-of-function 17924331, 16489001, 18451181 -BRCA2 R2318Q Inconclusive Inconclusive 16489001 -BRCA2 D3095E Likely Oncogenic Likely Loss-of-function 17924331, 18451181 -BRCA2 G1771D Inconclusive Inconclusive 17924331 -BRCA2 R2784W Likely Oncogenic Likely Loss-of-function 18451181 -BRCA2 D935N Inconclusive Inconclusive 18375895 -BRCA2 P168T Inconclusive Inconclusive 17924331 -BRCA2 P1819S Likely Neutral Likely Neutral 17924331, 18824701 -BRCA2 H1966Y Inconclusive Inconclusive 18824701 -BRCA2 L2865V Likely Neutral Likely Neutral 18451181 -BRCA2 R2502C Inconclusive Inconclusive 17924331 -BRCA2 R174C Likely Oncogenic Likely Loss-of-function 22962691 -BRCA2 N2436I Inconclusive Inconclusive 17924331 -BRCA2 R2842H Inconclusive Inconclusive 17924331 -BRCA2 K1690N Inconclusive Inconclusive 17924331 -BRCA2 F1524V Inconclusive Inconclusive 17924331 -BRCA2 L2106P Inconclusive Inconclusive 18824701 -BRCA2 H1918Y Inconclusive Inconclusive 17924331 -BRCA2 D1352Y Inconclusive Inconclusive 18824701 -BRCA2 C1265S Inconclusive Inconclusive 16489001 -BRCA2 D1280V Inconclusive Inconclusive 17924331 -BRCA2 K513R Likely Neutral Likely Neutral 17924331, 18375895 -BRCA2 Y42C Likely Neutral Likely Neutral 16489001, 18451181, 18824701, 15290653 -BRCA2 S196N Likely Oncogenic Likely Loss-of-function 22962691 -BRCA2 D3170G Inconclusive Inconclusive 17924331 -BRCA2 G173C Likely Oncogenic Likely Loss-of-function 22962691 -BRCA2 A2770T Inconclusive Inconclusive 16489001 -BRCA2 I2285V Likely Neutral Likely Neutral 17924331, 18824701 -BRCA2 V211I Likely Oncogenic Likely Loss-of-function 19179552, 23451180, 22962691 -BRCA2 G2274V Inconclusive Inconclusive 16489001 -BRCA2 L2647P Likely Oncogenic Likely Loss-of-function 18451181 -BRCA2 D191G Likely Oncogenic Likely Loss-of-function 22962691 -BRCA2 C554W Inconclusive Inconclusive 17924331 -BRCA2 R2602T Likely Oncogenic Likely Loss-of-function 18424508, 22505045 -BRCA2 A1170V Inconclusive Inconclusive 18824701 -BRCA2 T3211K Inconclusive Inconclusive 18824701 -BRCA2 D1420Y Inconclusive Inconclusive 18824701 -BRCA2 R3052Q Inconclusive Inconclusive 17924331 -BRCA2 L1904V Inconclusive Inconclusive 17924331 -BRCA2 R2842C Likely Oncogenic Likely Loss-of-function 23108138 -BRCA2 W2626C Inconclusive Inconclusive 17924331 -BRCA2 T630I Inconclusive Inconclusive 17924331 -BRCA2 G2748D Likely Oncogenic Likely Loss-of-function 17924331, 18451181 -BRCA2 N56T Inconclusive Inconclusive 17924331 -BRCA2 K1434I Inconclusive Inconclusive 18824701 -BRCA2 N588D Inconclusive Inconclusive 18824701 -BRCA2 N1878K Inconclusive Inconclusive 18824701 -BRCA2 I2627F Likely Oncogenic Likely Loss-of-function 17924331, 18451181 -BRCA2 P655R Inconclusive Inconclusive 18824701, 15290653 -BRCA2 C1365Y Inconclusive Inconclusive 17924331 -BRCA2 M2676T Inconclusive Inconclusive 18824701 -BRCA2 V3079I Inconclusive Inconclusive 17924331 -BRCA2 D2723G Likely Oncogenic Likely Loss-of-function 17924331, 18451181 -BRCA2 D2723H Likely Oncogenic Likely Loss-of-function 16489001, 18451181, 15290653 -BRCA2 V894I Inconclusive Inconclusive 17924331 -BRCA2 C3198R Inconclusive Inconclusive 17924331 -BRCA2 T2722R Inconclusive Inconclusive 17924331 -BRCA2 G602R Inconclusive Inconclusive 17924331 -BRCA2 S1172L Likely Neutral Likely Neutral 17924331, 18375895, 18824701 -BRCA2 A2717S Inconclusive Inconclusive 18375895 -BRCA2 N1228D Inconclusive Inconclusive 17924331 -BRCA2 T3349A Inconclusive Inconclusive 17924331 -BRCA2 T582P Inconclusive Inconclusive 17924331 -BRCA2 R2502H Inconclusive Inconclusive 18824701 -BRCA2 P375S Inconclusive Inconclusive 17924331 -BRCA2 Q2858R Inconclusive Inconclusive 18375895 -BRCA2 Deletion Oncogenic Loss-of-function 12483515, 18501021, 27452521, 11239455, 22193408, 16199546 -BRCA2 S326R Inconclusive Inconclusive 18824701 -BRCA2 V2969M Inconclusive Inconclusive 17924331 -BRCA2 D2723A Likely Oncogenic Likely Loss-of-function 18451181 -BRCA2 S1733F Inconclusive Inconclusive 17924331 -BRCA2 Y3098H Inconclusive Inconclusive 17924331 -BRCA2 S869L Inconclusive Inconclusive 16489001 -BRCA2 V1306I Inconclusive Inconclusive 17924331 -BRCA2 S384F Likely Neutral Likely Neutral 16489001, 18824701 -BRCA2 V2908G Likely Neutral Likely Neutral 17924331, 18451181 -BRCA2 L209F Likely Neutral Likely Neutral 22962691 -BRCA2 R2973C Likely Neutral Likely Neutral 17924331, 18451181, 18824701 -BRCA2 T1354M Inconclusive Inconclusive 17924331 -BRCA2 D2312V Inconclusive Inconclusive 17924331 -BRCA2 I1929V Inconclusive Inconclusive 17924331 -BRCA2 L2721H Inconclusive Inconclusive 18824701 -BRCA2 H2074N Inconclusive Inconclusive 17924331 -BRCA2 L2396F Inconclusive Inconclusive 17924331 -BRCA2 Y3092C Inconclusive Inconclusive 17924331 -BRCA2 Q1396R Inconclusive Inconclusive 17924331 -BRCA2 Truncating Mutations Likely Oncogenic Likely Loss-of-function 20878484, 24312913, 11239455, 22193408, 10570174 -BRCA2 S2670L Likely Neutral Likely Neutral 16489001 -BRCA2 N987I Inconclusive Inconclusive 18824701 -BRCA2 Q2384K Inconclusive Inconclusive 17924331 -BRCA2 S142I Likely Oncogenic Likely Loss-of-function 21638052 -BRCA2 E3002K Likely Oncogenic Likely Loss-of-function 21947752, 23108138, 20694749 -BRCA2 K2950N Likely Neutral Likely Neutral 17924331, 18375895 -BRCA2 L1019V Inconclusive Inconclusive 17924331 -BRCA2 R18H Inconclusive Inconclusive 18375895 -BRCA2 D2665G Likely Neutral Likely Neutral 17924331, 16489001 -BRCA2 R2336P Likely Oncogenic Likely Loss-of-function 22505045, 9150172 -BRCA2 K2411T Inconclusive Inconclusive 17924331 -BRCA2 R2659T Likely Oncogenic Likely Loss-of-function 18451181 -BRCA2 N2048I Inconclusive Inconclusive 17924331 -BRCA2 N2829R Likely Oncogenic Likely Loss-of-function 22505045 -BRCA2 N319T Likely Neutral Likely Neutral 18451181 -BRCA2 E462G Likely Neutral Likely Neutral 17924331, 18451181 -BRCA2 G1529R Inconclusive Inconclusive 17924331 -BRCA2 S1424C Inconclusive Inconclusive 18824701 -BRCA2 I2675V Likely Oncogenic Likely Loss-of-function 18424508 -BRCA2 R2108H Inconclusive Inconclusive 17924331 -BRCA2 R2336H Likely Oncogenic Loss-of-function 17924331, 18451181, 18489799 -BRCA2 G1194D Inconclusive Inconclusive 17924331 -BRCA2 L2653P Likely Oncogenic Likely Loss-of-function 17924331, 18451181 -NF2 Truncating Mutations Likely Oncogenic Likely Loss-of-function 19545378, 8755919, 22825583, 9643284 -NF2 Q324L Likely Neutral Likely Neutral 11448944 -NF2 A211D Likely Oncogenic Likely Loss-of-function 21383154, 20178741 -NF2 L535P Likely Oncogenic Likely Loss-of-function 21383154, 20178741, 10712203, 11448944 -NF2 L46R Likely Oncogenic Likely Loss-of-function 21383154, 20178741 -NF2 L64P Likely Oncogenic Likely Loss-of-function 20178741, 11448944 -NF2 T352M Likely Neutral Likely Neutral 10712203, 11448944 -NF2 K79E Likely Oncogenic Likely Loss-of-function 10712203, 11448944 -NF2 K413E Inconclusive Inconclusive 21383154, 11448944 -NF2 E106G Likely Oncogenic Likely Loss-of-function 11448944 -NF2 Q538P Likely Oncogenic Likely Loss-of-function 11448944 -NF2 Deletion Likely Oncogenic Likely Loss-of-function 24726726, 15645494, 19451229, 22825583, 9643284 -PAX8 PAX8-PPAR? Fusion Oncogenic Gain-of-function 17131411, 10958784 -NFE2L2 W24S Likely Oncogenic Gain-of-function 24142871, 18757741, 1875774 -NFE2L2 D77H Likely Oncogenic Likely Gain-of-function 16888629, 26619011 -NFE2L2 E82V Likely Oncogenic Likely Gain-of-function 12167159 -NFE2L2 E79K Likely Oncogenic Gain-of-function 24142871, 18757741, 1875774 -NFE2L2 G31R Oncogenic Gain-of-function 27147599 -NFE2L2 G31A Oncogenic Gain-of-function 27147599 -NFE2L2 D29N Likely Oncogenic Gain-of-function 24142871, 18757741, 1875774 -NFE2L2 G81S Likely Oncogenic Gain-of-function 24142871, 18757741, 1875774 -NFE2L2 I28T Likely Oncogenic Gain-of-function 24142871, 18757741, 1875774 -NFE2L2 T80A Likely Oncogenic Gain-of-function 24142871, 18757741, 1875774 -NFE2L2 E82G Likely Oncogenic Gain-of-function 23365135 -NFE2L2 D29H Likely Oncogenic Gain-of-function 24142871, 18757741, 1875774 -NFE2L2 W24C Likely Oncogenic Gain-of-function 24142871, 18757741, 1875774 -NFE2L2 G81D Likely Oncogenic Gain-of-function 24142871, 18757741, 1875774 -NFE2L2 E79Q Likely Oncogenic Gain-of-function 24142871, 18757741, 1875774 -NFE2L2 G31V Oncogenic Gain-of-function 27147599 -NFE2L2 E82D Likely Oncogenic Likely Gain-of-function 24130096, 18757741 -NFE2L2 V32G Likely Oncogenic Gain-of-function 24142871, 18757741, 1875774 -NFE2L2 T80R Likely Oncogenic Gain-of-function 24142871, 18757741, 1875774 -NFE2L2 W24R Likely Oncogenic Gain-of-function 24142871, 18757741, 1875774 -NFE2L2 T80K Oncogenic Gain-of-function 24130096, 27147599, 18757741 -NFE2L2 D29Y Likely Oncogenic Gain-of-function 24142871, 18757741, 1875774 -NFE2L2 G81R Likely Oncogenic Gain-of-function 24142871, 18757741, 1875774 -NFE2L2 L30F Likely Oncogenic Gain-of-function 24142871, 18757741, 1875774 -GLI1 R380A Likely Oncogenic Likely Loss-of-function 25476449 -GLI1 Amplification Oncogenic Gain-of-function 3563490, 1825351 -FUBP1 Truncating Mutations Likely Oncogenic Likely Loss-of-function 22072542, 22588899, 21817013, 24117486 -BTK C481S Likely Oncogenic Gain-of-function 25189416, 24869598 -BTK R544S Likely Oncogenic Likely Gain-of-function 20052711, 20826165 -BTK Y551F Likely Neutral Loss-of-function 20052711, 9188445, 20826165 -NFKBIA M37K Likely Neutral Likely Gain-of-function 23708964 -NFKBIA S36Y Likely Neutral Likely Gain-of-function 23864385 -NFKBIA E14* Likely Neutral Gain-of-function 18412279 -NFKBIA S32I Likely Neutral Gain-of-function 14523047 -GNA11 R183C Oncogenic Gain-of-function 21083380 -GNA11 Q209L Oncogenic Gain-of-function 21083380 -KDR C482R Likely Oncogenic Likely Gain-of-function 18931684, 25411163, 21712447 -KDR Q472H Likely Oncogenic Likely Gain-of-function 24793135, 24599305, 21712447 Mockus et al. Abstract# 73, AACR 2015 http://cancerres.aacrjournals.org/content/75/15_Supplement/73 -KDR Amplification Oncogenic Gain-of-function 11114740, 26578684 -KDR A1065T Likely Oncogenic Gain-of-function 19723655 -KDR D717V Oncogenic Gain-of-function 19723655 -KDR R961W Inconclusive Inconclusive 27004155 -KDR T771R Inconclusive Inconclusive 26422291, 19723655 -BCL10 Truncating Mutations Likely Oncogenic Likely Loss-of-function 10319863, 9989495 -BCL10 Deletion Likely Oncogenic Likely Loss-of-function 10319863, 9989495, 10845924 -GNAQ R183Q Likely Oncogenic Likely Gain-of-function 22236444 -GNAQ Q209L Oncogenic Gain-of-function 19078957, 1328859, 21083380 -GNAS R201H Oncogenic Gain-of-function 26257060, 24498386 -GNAS Q227R Likely Oncogenic Likely Gain-of-function 2549426 -GNAS R201C Oncogenic Gain-of-function 25288233, 20531296 -GNAS R844H Oncogenic Gain-of-function 15148396, 19423757 -GNAS Q227L Likely Oncogenic Likely Gain-of-function 2549426 -MGA Deletion Likely Oncogenic Likely Loss-of-function 10601024 -MGA Truncating Mutations Likely Oncogenic Likely Loss-of-function 23039309 -KIT W557_V560del Likely Oncogenic Likely Gain-of-function 23775962, 18955458 -KIT N822Y Likely Oncogenic Likely Gain-of-function 21689725, 18724244 -KIT Y570H Likely Oncogenic Likely Gain-of-function 21642685 -KIT A504_Y505ins Likely Oncogenic Likely Gain-of-function 16551858 -KIT Amplification Likely Oncogenic Likely Gain-of-function 15650049, 18506689, 16166280, 21523721, 19779861, 15869870, 24868028, 17189383 -KIT P577_W582delinsPYD Likely Oncogenic Likely Gain-of-function 23775962 -KIT D816E Likely Oncogenic Likely Gain-of-function 16551858, 25239608, 16397263 -KIT D52N Likely Oncogenic Likely Gain-of-function 9168438 -KIT V560G Oncogenic Gain-of-function 15790786, 16434489, 14645423, 16954519, 16397263 -KIT Exon 9 mutations Oncogenic Gain-of-function 18235121, 12181401, 23076159, 17662946, 24061512, 18955458, 16098458, 15451219 -KIT V559D Oncogenic Gain-of-function 15790786, 17372901, 18980976, 18955458, 16954519, 25605837, 15930355, 17699867, 9438854 -KIT D820Y Likely Oncogenic Likely Switch-of-function 14977822, 16551858, 18623623, 23840364, 25239608, 22614970, 18955458, 15930355, 17699867 -KIT P551_M552del Likely Oncogenic Likely Gain-of-function 18955458 -KIT K558_E562del Likely Oncogenic Likely Gain-of-function 25735500 -KIT P551_E554del Oncogenic Gain-of-function 25239608, 16954519 -KIT Exon 11 mutations Oncogenic Gain-of-function 18235121, 17372901, 25079768, 12181401, 17046465, 19282169, 25641662, 16098458, 15451219, 23177515, 19536093 -KIT K558_V559del Likely Oncogenic Likely Gain-of-function 18955458, 16954519 -KIT N505I Oncogenic Gain-of-function 24317392 -KIT W557G Likely Oncogenic Likely Gain-of-function 10224103, 25079768, 15342366 -KIT R634W Oncogenic Gain-of-function 15790786 -KIT W557_K558del Oncogenic Gain-of-function 14645423, 25239608, 16954519, 15930355, 17699867 -KIT D419del Likely Oncogenic Gain-of-function 16143141, 23599150 -KIT T417_D419delinsRG Oncogenic Gain-of-function 15790786 -KIT V569_L576del Likely Oncogenic Likely Gain-of-function 16551858, 15930355 -KIT L576P Oncogenic Gain-of-function 22357254, 17372901, 26264378, 18980976, 25605837, 15930355, 19671763, 22068222, 23775962, 21642685, 25695690, 18955458, 16954519 -KIT V559I Likely Oncogenic Gain-of-function 17259998 -KIT T670I Oncogenic Gain-of-function 16551858, 17545544, 23840364, 16954519, 17699867 -KIT N822K Oncogenic Gain-of-function 15790786, 23840364, 21482694, 24490049, 21642685, 25695690, 22614970, 16954519, 26316776, 17699867 -KIT Y553N Likely Oncogenic Likely Gain-of-function 21969494, 22357254 -KIT D820G Likely Oncogenic Likely Gain-of-function 16551858, 18623623, 23840364, 18955458, 16954519, 21456006 -KIT D816G Oncogenic Gain-of-function 25239608 -KIT K558delinsNP Oncogenic Gain-of-function 11526490, 25239608, 18955458, 16954519 -KIT T574insTQLPYD Likely Oncogenic Likely Gain-of-function 15930355 -KIT N822I Oncogenic Gain-of-function 21689725 -KIT W557R Likely Oncogenic Gain-of-function 14977822, 10224103, 19018266, 22357254, 21953054, 25079768, 21325067, 18980976, 21906875, 21642685, 20859122, 12888812 -KIT N463S Likely Oncogenic Likely Gain-of-function 21642685 -KIT C809G Likely Oncogenic Likely Gain-of-function 17139461, 18955458, 16954519 -KIT K550_K558del Oncogenic Gain-of-function 16954519, 9438854 -KIT D816F Oncogenic Gain-of-function 16397263 -KIT S501_A502dup Likely Oncogenic Gain-of-function 22324351 -KIT I653T Likely Oncogenic Likely Gain-of-function 21642685 -KIT E554_I571del Likely Oncogenic Likely Gain-of-function 16954519 -KIT V560E Likely Oncogenic Likely Gain-of-function 21690468, 22350270, 25239608 -KIT S709F Likely Oncogenic Likely Gain-of-function 16551858 -KIT P577_D579del Likely Oncogenic Likely Gain-of-function 22357254 -KIT D60N Likely Oncogenic Gain-of-function 24211109, 16226710 -KIT D572A Likely Oncogenic Gain-of-function 19865100 -KIT D816N Likely Oncogenic Gain-of-function 11369651 -KIT S476I Likely Oncogenic Gain-of-function 19865100 -KIT V559G Oncogenic Gain-of-function 23348204, 12569358 -KIT N564_Y578del Likely Oncogenic Likely Gain-of-function 16952044 -KIT T574_R588delinsL Likely Oncogenic Likely Gain-of-function 18955458 -KIT K550_W557del Oncogenic Gain-of-function 25239608 -KIT P551_V555del Oncogenic Gain-of-function 9438854 -KIT N822H Likely Oncogenic Gain-of-function 14645423, 18955458, 16954519 -KIT I563_L576del Likely Oncogenic Likely Gain-of-function 15930355 -KIT V559A Likely Oncogenic Likely Gain-of-function 15897563, 19812602, 16908931, 9438854 -KIT Y568_L576delinsVN Likely Oncogenic Likely Gain-of-function 18955458 -KIT D816A Likely Oncogenic Likely Gain-of-function 18955458, 16397263 -KIT V555_V559del Likely Oncogenic Gain-of-function 18955458, 15930355 -KIT L576del Likely Oncogenic Gain-of-function 19802003, 12717247 -KIT D820E Likely Oncogenic Likely Gain-of-function 19461405, 25886408, 15685537 -KIT K558N Likely Oncogenic Likely Gain-of-function 18980976 -KIT K550_V555delinsI Oncogenic Gain-of-function 9438854 -KIT C443Y Likely Oncogenic Gain-of-function 19865100 -KIT Y553_Q556del Likely Oncogenic Gain-of-function 15690055 -KIT D816Y Oncogenic Gain-of-function 15790786, 15167915, 16397263, 15725473 -KIT D579del Likely Oncogenic Likely Gain-of-function 24419427, 18955458 -KIT K509I Likely Oncogenic Gain-of-function 19865100 -KIT V654A Likely Oncogenic Gain-of-function 18623623, 23840364, 21642685, 18955458, 16954519, 16751810 -KIT Y418_D419del Likely Oncogenic Gain-of-function 22825855, 19603346, 16143141 -KIT V559_G565del Likely Oncogenic Likely Gain-of-function 16551858 -KIT V559C Likely Oncogenic Likely Gain-of-function 15897563, 21642685, 25695690, 9438854 -KIT A502_Y503dup Oncogenic Gain-of-function 22350270, 25239608, 18955458, 16954519, 21527588, 17699867 -KIT Q556_K558del Likely Oncogenic Likely Gain-of-function 19369884, 17372901, 25079768 -KIT V559_V560del Oncogenic Gain-of-function 16551858, 15790786, 16954519 -KIT F522C Likely Oncogenic Gain-of-function 15070706 -KIT H697Y Oncogenic Gain-of-function 19861435 -KIT D814V Oncogenic Gain-of-function 12569358 -KIT D816H Oncogenic Gain-of-function 18623623, 16956837, 18980976, 25304235, 25239608, 18955458, 16954519, 16397263 -KIT E490K Likely Oncogenic Likely Gain-of-function 22357254 -KIT E839K Likely Neutral Neutral 15790786 -KIT N655K Likely Oncogenic Likely Gain-of-function 17489795 -KIT P573_D579del Likely Oncogenic Gain-of-function 12569358, 9438854 -KIT K642E Likely Oncogenic Gain-of-function 24855380, 23940219, 11526490, 25695690, 25304235, 25239608, 14645423, 16954519 -KIT V555_L576del Likely Oncogenic Gain-of-function 23840364 -KIT V560del Oncogenic Gain-of-function 22357254, 16551858, 19861435, 15201427, 25605837 -KIT V560D Oncogenic Gain-of-function 23775962, 16551858, 23840364, 25239608, 18955458, 16954519, 25605837, 9438854 -KIT Y823D Oncogenic Gain-of-function 20633291, 22069175, 16551858, 18623623, 22301675, 18980976, 22089421, 18955458, 16954519, 15930355 -KIT E554_V559del Likely Oncogenic Likely Gain-of-function 18980976 -KIT M541L Likely Oncogenic Likely Gain-of-function 25015329, 21757432, 15790786, 20664593, 21498700, 18795925, 16307017 -KIT D820A Likely Oncogenic Likely Gain-of-function 23840364, 25239608, 18955458, 16954519 -KIT R796G Likely Neutral Loss-of-function 20824047 -KIT 550_592del Oncogenic Gain-of-function 18235121, 17372901, 25079768, 12181401, 15365079, 16098458, 15451219 -KIT V530I Oncogenic Gain-of-function 20339585, 16081693 -KIT W557_V559delinsC Likely Oncogenic Likely Gain-of-function 18955458 -KIT V559del Likely Oncogenic Gain-of-function 23993026, 15236194, 10485475, 16751810 -KIT V852I Likely Oncogenic Likely Gain-of-function 21642685 -KIT P838L Likely Oncogenic Likely Gain-of-function 21642685 -KIT Y578C Likely Oncogenic Gain-of-function 23567324 -KIT T417_D419delinsI Oncogenic Gain-of-function 15790786 -KIT D737N Inconclusive Inconclusive 26863566 -KIT P551_W557delinsL Likely Oncogenic Likely Gain-of-function 25239608 -KIT D816V Oncogenic Gain-of-function 15972446, 19193436, 7479840, 26002753, 16434489, 16397263, 15725473, 15790786, 17545544, 22301675, 16254134, 14645423, 16779792, 23659595, 23416972 -KIT M552_W557del Likely Oncogenic Likely Gain-of-function 16551858, 16954519 -KIT Y553_K558del Likely Oncogenic Likely Gain-of-function 16954519 -KIT E554_K558del Likely Oncogenic Likely Gain-of-function 18955458, 16954519, 15930355 -KIT A829P Likely Oncogenic Likely Gain-of-function 18623623, 18980976, 21642685, 25239608, 18955458 -KIT M552_K558del Likely Oncogenic Likely Gain-of-function 25239608 -KIT Exon 11 deletions Oncogenic Gain-of-function 18235121, 17372901, 25079768, 12181401, 15365079, 16098458, 15451219 -FGF19 Amplification Likely Oncogenic Likely Gain-of-function 24265351, 21397858, 22309595 -MED12 G44S Oncogenic Switch-of-function 24746821 -MED12 Exon 1 mutations Oncogenic Gain-of-function 24980722 -MED12 Deletion Likely Oncogenic Likely Loss-of-function 23178117 -MED12 L1224F Likely Oncogenic Likely Gain-of-function 12218053, 26619011, 17612495, 26383637 -MED12 Exon 2 mutations Oncogenic Likely Gain-of-function 23738515, 25038752, 23913526, 21868628 -MED12 G44D Oncogenic Switch-of-function 24746821 -NOTCH1 Deletion Likely Oncogenic Likely Gain-of-function 22077063, 23734977, 20852131 -NOTCH1 V1578del Likely Oncogenic Likely Gain-of-function 22056382, 24651013, 16618740, 25806268, 15472075, 16738328 -NOTCH1 L1574P Oncogenic Gain-of-function 22056382, 24651013, 16618740, 25806268, 15472075, 16738328 -NOTCH1 L1678P Likely Oncogenic Gain-of-function 22056382, 24651013, 16618740, 25806268, 16738328 -NOTCH1 I1718T Likely Oncogenic Gain-of-function 22056382, 24651013, 16618740, 25806268, 16738328 -NOTCH1 A1701P Likely Oncogenic Gain-of-function 22056382, 24651013, 16618740, 25806268, 16738328 -NOTCH1 P2415del Likely Oncogenic Likely Gain-of-function 24651013, 25564152, 21948802, 15472075 -NOTCH1 L1593P Likely Oncogenic Gain-of-function 22056382, 24651013, 16618740, 25806268, 16738328 -NOTCH1 MIR143-NOTCH1 Fusion Likely Oncogenic Likely Gain-of-function 23999936 -NOTCH1 Q2405Rfs*17 Likely Oncogenic Likely Gain-of-function 24651013, 25564152, 21948802, 15472075 -NOTCH1 L2429V Likely Oncogenic Likely Gain-of-function 24651013, 25564152, 21948802, 15472075 -NOTCH1 V1676D Likely Oncogenic Gain-of-function 22056382, 24651013, 16618740, 25806268, 16738328 -NOTCH1 P2417A Likely Oncogenic Likely Gain-of-function 24651013, 25564152, 21948802, 15472075 -NOTCH1 V1671I Likely Oncogenic Likely Gain-of-function 24651013, 25376516, 15472075, 19340001 -NOTCH1 R1608S Likely Neutral Likely Neutral 24651013, 16738328 -NOTCH1 L1596H Likely Oncogenic Gain-of-function 22056382, 24651013, 16618740, 25806268, 16738328 -NOTCH1 V1605del Likely Oncogenic Likely Gain-of-function 22056382, 24651013, 16618740, 25806268, 15472075, 16738328 -NOTCH1 I1680N Likely Oncogenic Gain-of-function 22056382, 24651013, 16618740, 25806268, 16738328 -NOTCH1 SEC16A1-NOTCH1 Fusion Oncogenic Gain-of-function 22101766 -NOTCH1 G2430A Likely Oncogenic Gain-of-function 20823234 -NOTCH1 Truncating Mutations in the PEST Domain Likely Oncogenic Likely Gain-of-function 22056382, 24651013, 16618740, 25564152, 21948802, 25806268, 15472075 -NOTCH1 Q2416* Likely Oncogenic Likely Gain-of-function 24651013, 25564152, 21948802, 15472075 -NOTCH1 F1592S Likely Oncogenic Gain-of-function 22056382, 24651013, 16618740, 25806268, 16738328 -NOTCH1 Truncating Mutations Upstream of Transactivation Domain Oncogenic Likely Loss-of-function 24651013, 22006338, 21798897, 21798893 -NOTCH1 V1576E Likely Oncogenic Gain-of-function 22056382, 24651013, 16618740, 25806268, 16738328 -NOTCH1 H2428Q Likely Oncogenic Likely Gain-of-function 24651013, 25564152, 21948802, 15472075 -NOTCH1 Fusions Likely Oncogenic Likely Gain-of-function 16688224, 22101766, 23033986 -NOTCH1 R1598P Likely Oncogenic Gain-of-function 22056382, 24651013, 16618740, 25806268, 16738328 -NOTCH1 L1600P Likely Oncogenic Gain-of-function 22056382, 24651013, 16618740, 25806268, 15472075, 16738328 -NOTCH1 P2412T Likely Oncogenic Likely Gain-of-function 24651013, 25564152, 21948802, 15472075 -NOTCH1 A2425T Likely Oncogenic Likely Gain-of-function 24651013, 25564152, 21948802, 15472075 -NOTCH1 I1616T Likely Oncogenic Gain-of-function 22056382, 24651013, 16618740, 25806268, 16738328 -NOTCH1 R1594Q Likely Oncogenic Loss-of-function 24651013, 22006338, 27228302 -NOTCH1 G2420C Likely Oncogenic Likely Gain-of-function 24651013, 25564152, 21948802, 15472075 -NOTCH1 I1616N Likely Oncogenic Gain-of-function 22056382, 24651013, 16618740, 25806268, 16738328 -NOTCH2 2010_2471trunc Likely Oncogenic Likely Gain-of-function 21378989 -NOTCH2 1_2009trunc Likely Oncogenic Likely Loss-of-function 22006338 -RAC1 P29S Oncogenic Gain-of-function 2546593, 22842228, 23284172, 25056119, 25465943 -RAC1 Q61R Likely Oncogenic Gain-of-function 26619011 -RAC1 C18Y Likely Oncogenic Gain-of-function 28115009 -RAC1 Amplification Likely Oncogenic Gain-of-function 24072884, 23474757 -RAC1 G12V Oncogenic Gain-of-function 23382236, 23284172 -RAC1 C157Y Likely Oncogenic Gain-of-function 23382236 -RAC1 P29L Oncogenic Gain-of-function 23382236 -DNMT3A R882C Likely Oncogenic Likely Gain-of-function 24656771, 27010239 -DNMT3A R882H Likely Oncogenic Likely Gain-of-function 22722925, 24167195, 24656771, 25416276, 27010239 -DNMT3A Truncating Mutations Likely Oncogenic Likely Loss-of-function 21067377, 25964253, 24614070 -DNMT3A Deletion Likely Oncogenic Likely Loss-of-function 21067377, 27636998 -DNMT3B DNMT3B7 Likely Oncogenic Likely Switch-of-function 20587527, 23315164, 25607950, 22815530, 17353906 -DNMT3B Amplification Likely Oncogenic Likely Gain-of-function 25470049, 22810696 -RAD21 Truncating Mutations Likely Oncogenic Likely Loss-of-function 28116354, 25006131 -RAD21 Deletion Likely Oncogenic Likely Loss-of-function 28116354, 25006131 -RAD51 Truncating Mutations Likely Oncogenic Likely Loss-of-function -RAD51C A126T Likely Neutral Neutral 21990120, 26261251, 20400964, 21980511 -RAD51C Truncating Mutations Likely Oncogenic Likely Loss-of-function 20400963, 20400964, 21616938 -RAD51C G264S Likely Neutral Neutral 21990120, 26261251, 20400964 -RAD51B HMGA2-RAD51B Fusion Likely Oncogenic Likely Switch-of-function 9892177, 26787895, 11450849 -RAD51D Truncating Mutations Likely Oncogenic Likely Loss-of-function 23372765, 21822267, 22986143 -KRAS G12C Oncogenic Gain-of-function 25705018, 24256730, 16051643, 26841430 -KRAS G12D Oncogenic Gain-of-function 17349581, 24300897, 19296721, 26037647, 11751631, 15093544, 20570890, 20147967 -KRAS A146V Likely Oncogenic Gain-of-function 3043178, 26841430 -KRAS G12V Oncogenic Gain-of-function 20516123, 20949621, 25359494, 20570890, 12957286, 20147967 -KRAS Wildtype Likely Neutral Neutral 22810696, 12506171 NCCN Colon 2.2017 https://www.nccn.org/professionals/physician_gls/pdf/colon.pdf -KRAS T74P Likely Oncogenic Gain-of-function 19075190 -KRAS G13C Oncogenic Gain-of-function 25705018, 21079152 -KRAS Q61R Oncogenic Gain-of-function 21993244, 25363767, 24651010, 25437878 -KRAS T58I Oncogenic Gain-of-function 20949621, 16474405, 18509354 -KRAS Y71H Oncogenic Gain-of-function 23059812 -KRAS Q22R Likely Oncogenic Likely Gain-of-function 20949621, 21263000 -KRAS A18D Oncogenic Gain-of-function 19490892 -KRAS G13D Oncogenic Gain-of-function 20978259, 26037647, 22722830, 20147967 -KRAS R164Q Inconclusive Inconclusive 26274561, 20147967 -KRAS P34R Oncogenic Gain-of-function 8995293, 17875937, 20949621, 16474405 -KRAS E62K Oncogenic Gain-of-function 27147599 -KRAS G60R Oncogenic Gain-of-function 20949621 -KRAS F156L Oncogenic Gain-of-function 20949621, 17601930, 7877967 -KRAS G12R Oncogenic Gain-of-function 24893629, 26037647, 21831957, 22722830 -KRAS Q61H Oncogenic Gain-of-function 25705018, 21993244, 24651010, 20147967 -KRAS K117N Oncogenic Gain-of-function 20570890, 20147967 -KRAS Y32S Likely Oncogenic Gain-of-function 11333268, 26841430 -KRAS A11_G12insGA Oncogenic Gain-of-function 24642870 -KRAS G12A Oncogenic Gain-of-function 26662311, 26037647, 25013473, 23182985 -KRAS F28L Oncogenic Gain-of-function 25600866, 20949621, 16474405 -KRAS L19F Oncogenic Gain-of-function 17150185, 20147967 -KRAS K147E Oncogenic Gain-of-function 23059812 -KRAS Y40A Inconclusive Inconclusive 11333268, 26841430 -KRAS G12S Oncogenic Gain-of-function 26184075, 25284075 -KRAS P34L Oncogenic Gain-of-function 17875937, 20949621 -KRAS V14I Oncogenic Gain-of-function 25359213, 20949621, 16474405 -KRAS Q22K Oncogenic Gain-of-function 23059812, 11095964, 20570890 -KRAS Y64A Oncogenic Gain-of-function 12628188, 26841430 -KRAS Q22E Oncogenic Gain-of-function 20949621, 21263000 -KRAS Amplification Likely Oncogenic Likely Gain-of-function 23099803, 24874471, 20841479, 23404247 -KRAS G60D Inconclusive Inconclusive 21632860 -KRAS G12F Likely Oncogenic Likely Gain-of-function 20871262 -KRAS A59G Oncogenic Gain-of-function 27147599, 1221964, 26841430 -KRAS D119N Likely Oncogenic Likely Gain-of-function 8552403, 11103938 -KRAS A146T Oncogenic Gain-of-function 19075190, 20570890, 20147967, 2403644 -KRAS E31K Likely Neutral Likely Neutral 20570890, 16483931 -KRAS Q25H Inconclusive Inconclusive 21375404 -KRAS G13E Likely Oncogenic Likely Gain-of-function 19453520, 26619011, 17503413, 19521964 -KRAS K5N Oncogenic Gain-of-function 17875937, 20949621, 25941399 -KRAS S65N Oncogenic Gain-of-function 8626650, 24798740 -KRAS Q61L Oncogenic Gain-of-function 21993244, 25363767, 24651010, 26854029, 25437878 -KRAS D153V Oncogenic Gain-of-function 17875937, 20949621, 16474405, 25941399 -KRAS G10dup Oncogenic Gain-of-function 8955068 -KRAS N116H Inconclusive Inconclusive 26841430 -NPM1 Deletion Likely Oncogenic Likely Loss-of-function 18212245, 19322210, 20877721, 16007073 -NPM1 Truncating Mutations Likely Oncogenic Likely Loss-of-function 19322210, 20877721 -RAF1 S257W Likely Oncogenic Gain-of-function 12077328, 7867061, 17603483 -RAF1 S257L Oncogenic Gain-of-function 12077328, 7867061, 24569458, 17603483 -RAF1 Fusions Likely Oncogenic Likely Gain-of-function 27810072, 19363522, 20526349, 23637631 -RAF1 I448V Oncogenic Gain-of-function 19357705 -RAF1 S259A Oncogenic Gain-of-function 24569458, 20679480 -RAF1 ESRP1-RAF1 Fusion Oncogenic Gain-of-function 20526349 -RAF1 S427G Oncogenic Gain-of-function 16585161, 19357705 -RAF1 S259F Oncogenic Gain-of-function 17603483, 20679480 -RAF1 P261L Likely Oncogenic Likely Gain-of-function 17603483, 20679480 -RAF1 Amplification Oncogenic Gain-of-function 11389083, 21215703, 16517112 Zehir A et al. Nature Medicine 2017 http://doi:10.1038/nm.4333 -RAF1 ATG7-RAF1 Fusion Likely Oncogenic Likely Gain-of-function 23637631 -RAF1 S259P Likely Oncogenic Gain-of-function 20679480 -RAF1 SRGAP3-RAF1 Fusion Oncogenic Gain-of-function 19363522 -RAB35 F161L Oncogenic Gain-of-function 26338797 -RAB35 A151T Oncogenic Gain-of-function 26338797 -HNF1A Truncating Mutations Likely Oncogenic Likely Loss-of-function 12574234, 18003757, 25793983 -HNF1A T196A Likely Neutral Neutral 21170474 -HNF1A Deletion Likely Oncogenic Likely Loss-of-function 12574234, 25793983 -HNF1A P291Qfs*51 Likely Oncogenic Likely Loss-of-function 12574234, 9313763, 16917892 -AKT3 Amplification Oncogenic Gain-of-function 17178867, 24138071, 18451171, 25737557, 15466193, 20647317 -AKT3 E17K Likely Oncogenic Gain-of-function 18813315 -AKT3 Fusions Likely Oncogenic Likely Gain-of-function 22722202 -AKT3 MAGI3-AKT3 Fusion Oncogenic Gain-of-function 22722202 -TCF3 N551K Likely Oncogenic Loss-of-function 24492847, 22885699 -TCF7L2 Truncating Mutations Likely Oncogenic Likely Loss-of-function 10919662, 16547505, 18478343, 18599616, 10485457 -RARA R276W Inconclusive Inconclusive 27148563, 23670176, 19865110, 11438209 -NRAS Q61R Oncogenic Gain-of-function 25277205, 21993244, 20194776, 23515407, 24651010, 19492075 -NRAS G12C Likely Oncogenic Likely Gain-of-function 21993244, 24651010 -NRAS Amplification Inconclusive Inconclusive 26266759, 25263998, 22876308 Zehir A et al. Nature Medicine, 2017 http://doi:10.1038/nm.4333 -NRAS G13D Oncogenic Gain-of-function 26037647, 21993244, 24651010, 22722830 -NRAS G12R Oncogenic Gain-of-function 21993244, 24651010 -NRAS Q61H Oncogenic Gain-of-function 21993244, 20194776, 23515407, 24651010 -NRAS G13V Likely Oncogenic Likely Gain-of-function 20371679, 21993244, 24651010 -NRAS Q61K Oncogenic Gain-of-function 25277205, 21993244, 20194776, 23515407, 24651010, 19492075 -NRAS Q61L Oncogenic Gain-of-function 25277205, 21993244, 20194776, 23515407, 24651010, 19492075 -NRAS T50I Likely Oncogenic Likely Gain-of-function 22817889, 19966803 -NRAS G12D Oncogenic Gain-of-function 21993244, 23687087, 24651010, 25252692, 18372904 -NRAS G12V Oncogenic Gain-of-function 18952898, 21993244, 21478863, 24651010 -NRAS G60E Likely Oncogenic Gain-of-function 19075190, 19966803, 10716188, 21263000 -NRAS T58I Likely Oncogenic Likely Gain-of-function 24265153, 16474405 -RASA1 Deletion Likely Oncogenic Likely Loss-of-function 2173144, 9121432, 9034330, 1689011 -RASA1 Y472H Likely Oncogenic Likely Loss-of-function 26993606 -RASA1 Truncating Mutations Likely Oncogenic Likely Loss-of-function 2173144, 9121432, 9034330, 1689011, 24038909 -RASA1 L481F Likely Oncogenic Likely Loss-of-function 26993606 -BCL2L11 Truncating Mutations Likely Oncogenic Likely Loss-of-function 24737648, 23382048, 26076815, 23559152, 21652541, 26001141, 23116058 -BCL2L11 Single Nucleotide Polymorphism Oncogenic Loss-of-function 24223824 -BCL2L11 Deletion Oncogenic Likely Loss-of-function 22426421, 26076815, 23559152, 23116058 -RB1 R661W Inconclusive Inconclusive 16449662, 7927327, 9420334, 1352883, 18677112 -RB1 Truncating Mutations Likely Oncogenic Likely Loss-of-function 25621664, 22293180, 22205104 -RB1 R621C Likely Oncogenic Likely Loss-of-function 20594292 -RB1 C706F Likely Oncogenic Likely Loss-of-function 18677112 -RB1 L607I Likely Oncogenic Likely Loss-of-function 20594292 -RB1 N480del Likely Neutral Likely Neutral 18677112 -RB1 R698W Likely Oncogenic Likely Loss-of-function 20594292 -RB1 Deletion Likely Oncogenic Likely Loss-of-function 16127685, 17854503, 23960888 -RB1 S567L Likely Oncogenic Likely Loss-of-function 10671068, 9420334 -RB1 C712R Likely Neutral Likely Neutral 18677112 -RB1 W563L Inconclusive Inconclusive 16269091, 10882758 -KDM5A Amplification Likely Oncogenic Likely Gain-of-function 22937203, 2293720 -NTRK1 TFG-NTRK1 Fusion Likely Oncogenic Gain-of-function 7565764, 9488046 -NTRK1 Fusions Likely Oncogenic Likely Gain-of-function 24162815 -NTRK1 NFASC-NTRK1 Fusion Oncogenic Gain-of-function 24647444 -NTRK1 TPM3-NTRK1 Fusion Oncogenic Gain-of-function 2869410, 2927393, 24962792 -NTRK1 S677N Likely Oncogenic Likely Gain-of-function 18270328 -NTRK1 BCAN-NTRK1 Fusion Likely Oncogenic Likely Gain-of-function 24647444 -NTRK1 V710A Likely Neutral Loss-of-function 27272783 -NTRK1 Delta-NTRK1 Fusion Oncogenic Gain-of-function 11073967 -NTRK1 LMNA-NTRK1 Fusion Oncogenic Gain-of-function 24445538 -NTRK1 Amplification Likely Oncogenic Gain-of-function 26496938 -NTRK1 TPR-NTRK1 Fusion Oncogenic Gain-of-function 9172002, 1532241, 7851906 -NTRK1 TRKAIII Splice Variant Oncogenic Gain-of-function 15488758 -NTRK1 MPRIP-NTRK1 Fusion Oncogenic Gain-of-function 24162815 -NTRK1 R342Q Likely Oncogenic Gain-of-function 1695324, 11313867, 23000897, 23636398, 22460905 -NTRK1 CD74-NTRK1 Fusion Oncogenic Gain-of-function 24162815 -NTRK1 CHTOP-NTRK1 Fusion Likely Oncogenic Likely Gain-of-function 24647444, 25384085 -NTRK1 R342W Likely Oncogenic Gain-of-function 1695324, 11313867, 23636398, 22460905 -NTRK2 M713I Likely Neutral Likely Loss-of-function 21242122 -NTRK2 Fusions Likely Oncogenic Likely Gain-of-function 26565381, 25204415, 26216294, 26884591, 24647444, 24445538, 26457764, 26797418, 24162815, 27843590, 26603524 -NTRK2 R734C Likely Neutral Likely Loss-of-function 21242122 -NTRK2 R715G Likely Neutral Likely Neutral 21242122 -NTRK3 Fusions Likely Oncogenic Likely Gain-of-function 26565381, 25204415, 26216294, 26884591, 27843950, 26457764, 26797418, 27148571, 26603524 -NTRK3 ETV6-NTRK3 Fusion Oncogenic Gain-of-function 10702799, 12450792 -NTRK3 G623R Likely Oncogenic Likely Gain-of-function 26884591 -NTRK3 CPEB1-NTRK3 Fusion Oncogenic Gain-of-function 24705251 -NTRK3 BTBD1-NTRK3 Fusion Oncogenic Gain-of-function 24705251 -DUSP4 Deletion Inconclusive Inconclusive 21317287, 19525976 -DDR2 Amplification Likely Oncogenic Likely Gain-of-function 24505276, 26362312, 28099935 -DDR2 L239R Oncogenic Gain-of-function 22328973, 23335507 -DDR2 L63V Oncogenic Gain-of-function 23822953, 22328973 -DDR2 G505S Likely Oncogenic Gain-of-function 23822953, 22328973 -DDR2 G774V Oncogenic Gain-of-function 22328973 -DDR2 T654I Inconclusive Inconclusive 24296828 -DDR2 G253C Oncogenic Gain-of-function 22328973, 23335507 -DDR2 T654M Inconclusive Inconclusive 22328973, 24296828 -DDR2 S768R Likely Oncogenic Likely Gain-of-function 22328973, 25173530 -DDR2 I638F Inconclusive Inconclusive 23822953, 22328973 -SOX17 Deletion Likely Oncogenic Likely Loss-of-function 17655922, 28237397, 24407731, 20716954, 17875931, 18413743, 19301122, 27738313, 21514720, 24153254, 27102016, 22846201 -SOX17 Truncating Mutations Likely Oncogenic Likely Loss-of-function -NSD1 NSD1-NUP98 Fusion Likely Oncogenic Likely Gain-of-function 11895789, 23630019 -NSD1 Fusions Likely Oncogenic Likely Gain-of-function 11895789, 23630019, 27889185 -CASP8 Truncating Mutations Likely Oncogenic Likely Loss-of-function 15531912, 19852930, 15705878, 12949717 -CASP8 G325A Likely Oncogenic Gain-of-function 23659359 -CASP8 Promoter Hypermethylation Likely Oncogenic Loss-of-function 16397500, 10969767, 11593392 -CASP8 CASP8L Likely Oncogenic Loss-of-function 12010809, 10860845, 15735742, 16374545 -CASP8 Deletion Likely Oncogenic Likely Loss-of-function 15531912, 12055196, 15705878 -CASP8 C248T Likely Neutral Neutral 12353035 -RET C618R Oncogenic Gain-of-function 9230192 -RET R833C Likely Oncogenic Likely Gain-of-function 21810974 -RET V804M Oncogenic Gain-of-function 17047083 -RET E768D Likely Oncogenic Likely Gain-of-function 10445857 -RET C634R Oncogenic Gain-of-function 9230192 -RET R886W Oncogenic Gain-of-function 21551259 -RET V804L Likely Oncogenic Likely Gain-of-function 15184865, 9242375 -RET Fusions Likely Oncogenic Likely Gain-of-function 25064355, 24561444, 22327623 -RET E632_L633del Likely Oncogenic Gain-of-function 9191060 -RET C609Y Oncogenic Gain-of-function 9230192 -RET S765P Likely Neutral Loss-of-function 11438491 -RET C634W Likely Oncogenic Likely Gain-of-function 17664273, 9230192 -RET E511K Likely Oncogenic Likely Gain-of-function 20103606, 21551259 -RET M918V Likely Oncogenic Likely Gain-of-function 21810974 -RET K603Q Likely Oncogenic Likely Gain-of-function 15277225, 11746981 -RET S904F Likely Oncogenic Likely Gain-of-function 21810974 -RET C630R Oncogenic Gain-of-function 9230192 -RET S891A Oncogenic Gain-of-function 24561444, 20554711 -RET L790F Oncogenic Gain-of-function 20444924, 15753368 -RET RET-CCDC6 Fusion Oncogenic Gain-of-function 23578175 -RET R897Q Likely Neutral Loss-of-function 11438491 -RET M918T Oncogenic Gain-of-function 8755580, 22584710, 7824936, 9681850, 24561444 -RET C634Y Likely Oncogenic Gain-of-function 9230192 -RET A919V Likely Oncogenic Likely Gain-of-function 19186126 -RET E921K Likely Neutral Loss-of-function 11438491 -RET V804G Likely Neutral Likely Loss-of-function 15184865 -RET G885R Likely Neutral Likely Neutral 25733075, 24336963 -RET M848T Likely Oncogenic Likely Gain-of-function 21810974 -RET T338I Likely Neutral Likely Neutral 21810974 -RET C634S Likely Oncogenic Gain-of-function 15277225 -RET KIF5B-RET Fusion Oncogenic Gain-of-function 22327624 -RET D631G Likely Neutral Likely Neutral 10049754 -RET I852M Likely Oncogenic Likely Gain-of-function 21711375, 11295841 -RET A919P Inconclusive Inconclusive 16928683 -RET D631A Likely Neutral Likely Neutral 10049754 -RET F893L Likely Neutral Loss-of-function 11438491 -RET Y806C Likely Oncogenic Likely Gain-of-function 19029224 -RET Y791F Likely Oncogenic Gain-of-function 15753368, 9506724, 12490841, 17209045 -RET C620R Oncogenic Gain-of-function 9230192 -RET A883F Oncogenic Gain-of-function 24561444 -RET M980T Likely Neutral Likely Neutral 11438491 -RET C611Y Oncogenic Gain-of-function 9230192 -RET V648I Likely Neutral Likely Neutral 21810974 -RET A883T Oncogenic Gain-of-function 15531548, 21810974 -RET R873Q Likely Neutral Loss-of-function 11438491 -RUNX1 Truncating Mutations Likely Oncogenic Likely Loss-of-function 15864279, 15386419, 17394134 -RUNX1 R174Q Oncogenic Loss-of-function 25490895, 21725049, 17290219 -RUNX1 R201Q Likely Oncogenic Loss-of-function 10508512 -RUNX1 RUNX1-RUNX1T1 Fusion Likely Oncogenic Loss-of-function 19414342, 21174539, 4125056, 9819404 -RUNX1 Amplification Oncogenic Gain-of-function 25592647 -RUNX1 D171G Likely Oncogenic Likely Loss-of-function 22318203 -RUNX1 H78Q Likely Oncogenic Loss-of-function 22318203 -RUNX1 D171N Oncogenic Loss-of-function 18192504, 12393679 -RUNX1 R139G Likely Oncogenic Loss-of-function 22318203 -RUNX1 R166Q Likely Oncogenic Loss-of-function 10508512 -RUNX1 R177* Oncogenic Loss-of-function 10068652, 11830488, 15156185 -RUNX1 G42R Inconclusive Inconclusive 18192504, 12874780, 12393679 -RUNX1 Y113* Oncogenic Loss-of-function 18192504 -RUNX1 S291fsX300 Oncogenic Loss-of-function 18192504 -RUNX1 K83N Likely Oncogenic Loss-of-function 11830488, 15156185 -RUNX1 K83E Likely Oncogenic Loss-of-function 11830488, 15156185 -RUNX1 R174* Oncogenic Gain-of-function 26021490, 20549580 -RUNX1 R177Q Oncogenic Loss-of-function 11830488, 18192504 -RUNX1 RUNX1-EVI1 Fusion Likely Oncogenic Loss-of-function 15156182, 19016745 -RUNX1 P173S Oncogenic Loss-of-function 18192504 -RUNX1 W279* Likely Oncogenic Likely Loss-of-function 25893166 -RUNX1 S70fsX93 Oncogenic Loss-of-function 18192504 -RUNX1 R80C Likely Oncogenic Loss-of-function 15156185 -RUNX1 Fusions Likely Oncogenic Likely Loss-of-function 21174539 -RUNX1 A122* Likely Oncogenic Likely Loss-of-function 18192504 -RUNX1 TEL-RUNX1 Fusion Likely Oncogenic Loss-of-function 15156184 +FAM58A Truncating Mutations Likely Oncogenic Likely Loss-of-function 24218572, 18297069 +CBL H94Y Inconclusive Inconclusive 20126411, 26676746 +CBL M374V Likely Neutral Likely Neutral 26676746 +CBL R420Q Oncogenic Loss-of-function 25178484, 17446348, 19387008, 19734451 +CBL V391I Likely Oncogenic Loss-of-function 26676746 +CBL Deletion Likely Oncogenic Likely Loss-of-function 19276253, 19901108, 22315494 +CBL W802* Likely Oncogenic Likely Gain-of-function 20126411 +CBL Y371H Oncogenic Loss-of-function 23696637, 26676746 +CBL V430M Likely Neutral Likely Neutral 26676746 +CBL H398Y Likely Oncogenic Loss-of-function 19387008 +CBL Y371S Oncogenic Loss-of-function 19620960 +CBL K382E Likely Oncogenic Loss-of-function 25178484, 26676746 +CBL Truncating Mutations Likely Oncogenic Likely Loss-of-function 20508043, 20694012, 22315494 +CBL S376F Likely Oncogenic Loss-of-function 19387008 +CBL P417A Likely Oncogenic Loss-of-function 19387008 +CBL P428L Likely Neutral Likely Neutral 26676746 +CBL C381A Likely Oncogenic Loss-of-function 25178484, 26676746 +CBL C396R Likely Oncogenic Loss-of-function 26676746 +CBL S80N Inconclusive Inconclusive 20126411, 26676746 +CBL G375P Likely Oncogenic Loss-of-function 26676746 +CBL P395A Likely Oncogenic Loss-of-function 26676746 +CBL H398Q Likely Oncogenic Loss-of-function 26676746 +CBL D390Y Likely Oncogenic Loss-of-function 25178484 +CBL L399V Likely Oncogenic Loss-of-function 26676746 +CBL C384R Oncogenic Loss-of-function 23696637 +CBL Q367P Oncogenic Loss-of-function 19620960 +CBL N454D Likely Neutral Neutral 19387008 +CBL Q249E Likely Oncogenic Likely Gain-of-function 20126411 +SHOC2 M173I Likely Oncogenic Loss-of-function 25137548 +SHOC2 S2G Likely Oncogenic Loss-of-function 19684605, 23918763 +TERT H412Y Likely Oncogenic Loss-of-function 18042801 +TERT Promoter Mutations Oncogenic Gain-of-function 23348506, 23348503, 23887589, 24657534, 25048572, 23530248 +TERT P704S Likely Oncogenic Loss-of-function 18042801 +TERT Y846C Likely Oncogenic Loss-of-function 18042801 +TERT C250T Oncogenic Gain-of-function 23348506, 23348503, 23887589, 26389665, 24657534, 23530248 +TERT Amplification Likely Oncogenic Likely Gain-of-function 25219713, 18482052, 25301727 +TERT H876Q Likely Oncogenic Loss-of-function 18042801 +TERT C228T Oncogenic Gain-of-function 23348506, 23348503, 23887589, 24657534, 23530248 +DICER1 E1705K Likely Oncogenic Loss-of-function 22187960 +DICER1 E1705A Likely Oncogenic Loss-of-function 17920623 +DICER1 D1709N Oncogenic Loss-of-function 26033159, 22187960 +DICER1 D1709A Likely Oncogenic Likely Loss-of-function 22187960 +DICER1 Truncating Mutations Likely Oncogenic Likely Loss-of-function 20305640, 22133720, 21501861, 22353998, 21266384 +DICER1 D1709E Likely Oncogenic Likely Loss-of-function 22187960 +DICER1 D1810A Likely Oncogenic Loss-of-function 17920623 +DICER1 G1809K Likely Oncogenic Loss-of-function 26033159 +DICER1 G1809R Oncogenic Loss-of-function 26033159 +DICER1 Deletion Likely Oncogenic Likely Loss-of-function 20305640, 26513514, 27295554, 19903759, 22353998 +PTPRT T844M Likely Oncogenic Loss-of-function 24493670 +PTPRT A1022E Oncogenic Loss-of-function 24395800 +PTPRT R1343L Likely Oncogenic Loss-of-function 15155950 +PTPRT A707T Likely Oncogenic Likely Loss-of-function 20230342 +PTPRT Q984K Likely Oncogenic Loss-of-function 15155950, 22389709 +PTPRT N1125I Likely Oncogenic Loss-of-function 15155950, 22389709 +PTPRT Y412F Likely Oncogenic Likely Loss-of-function 20230342 +PTPRT Y280H Likely Oncogenic Likely Loss-of-function 18644975 +PTPRT L708P Likely Oncogenic Likely Loss-of-function 20230342 +PTPRT R1040L Oncogenic Likely Loss-of-function 24395800 +PTPRT A209T Likely Oncogenic Likely Loss-of-function 18644975 +PTPRT F74S Likely Oncogenic Likely Loss-of-function 15155950, 18644975 +PTPRT V648G Likely Oncogenic Likely Loss-of-function 20230342 +PTPRT R453C Likely Oncogenic Likely Loss-of-function 20230342 +PTPRT Promoter Hypermethylation Oncogenic Loss-of-function 25009298, 25982282, 23096495 +PTPRT Q479E Likely Oncogenic Likely Loss-of-function 20230342 +PTPRT S492F Likely Oncogenic Likely Loss-of-function 20230342 +PTPRT T1365M Likely Oncogenic Loss-of-function 15155950 +PTPRT F248S Likely Oncogenic Likely Loss-of-function 18644975 +PTPRT N510K Likely Oncogenic Likely Loss-of-function 20230342 +PTPRT V995M Likely Oncogenic Loss-of-function 24317090, 17360477 +PTPRT Truncating Mutations Likely Oncogenic Likely Loss-of-function 15155950, 20133777, 21517784 +PTPRT K218T Likely Oncogenic Likely Loss-of-function 18644975 +PTPRT T605M Likely Oncogenic Likely Loss-of-function 20230342 +PTPRT R1209W Likely Oncogenic Loss-of-function 15155950 +PTPRT D927G Likely Oncogenic Loss-of-function 22389709 +RHEB Y35H Likely Oncogenic Gain-of-function 24631838, 22819219 +RHEB Y35C Oncogenic Gain-of-function 24631838, 22819219 +RHEB Y35N Oncogenic Gain-of-function 24631838, 27399332, 22819219, 26255626 +SHQ1 Deletion Likely Oncogenic Likely Loss-of-function 19383767, 19019820, 20579941 +SHQ1 Truncating Mutations Likely Oncogenic Likely Loss-of-function +CCND2 Amplification Likely Oncogenic Likely Gain-of-function 8114739 +RAD50 L234fs Likely Oncogenic Likely Loss-of-function 16474176, 14684699, 16385572 +RAD50 Deletion Likely Oncogenic Likely Loss-of-function 12208847, 2659437, 14684699, 15309560 +RAD50 L1273F Likely Oncogenic Loss-of-function 24934408 +RAD50 Truncating Mutations Likely Oncogenic Likely Loss-of-function 12208847, 16288216, 21892167, 14684699 +CCND3 Amplification Likely Oncogenic Likely Gain-of-function 8114739 +CCND3 D286_L292trunc Likely Oncogenic Likely Gain-of-function 9832503 +CCND3 I290R Likely Oncogenic Likely Gain-of-function 2876518, 24913233, 22885699 +CCND3 T283A Likely Oncogenic Gain-of-function 2876518, 24913233, 22885699 +CCND3 T286A Likely Oncogenic Gain-of-function 9832503 +CCND3 I290A Likely Oncogenic Likely Gain-of-function 9832503 +CCND3 P284L Likely Oncogenic Likely Gain-of-function 2876518, 24913233, 22885699 +CCND3 Q276* Likely Oncogenic Gain-of-function 2876518, 24913233, 22885699 +RIT1 A77P Oncogenic Gain-of-function 24469055 +RIT1 A77T Likely Oncogenic Likely Gain-of-function 26714497 +RIT1 M90I Oncogenic Gain-of-function 24469055 +RIT1 A77S Oncogenic Gain-of-function 24469055 +CCNE1 Amplification Oncogenic Gain-of-function 8618861, 15838514, 12845634, 24605326 +CCNE1 Overexpression Oncogenic Gain-of-function 8618861, 15838514, 12845634, 24605326 +RYBP Truncating Mutations Likely Oncogenic Likely Loss-of-function 19098711 +TGFBR1 C41Y Likely Oncogenic Loss-of-function 21358634 +TGFBR1 N45S Likely Oncogenic Loss-of-function 21358634, 23358096 +TGFBR1 R487Q Likely Oncogenic Likely Loss-of-function 16928994, 25116393, 16791849 +TGFBR1 S241L Likely Oncogenic Likely Loss-of-function 16791849 +TGFBR1 G52R Likely Oncogenic Loss-of-function 21358634, 23358096 +TGFBR1 Truncating Mutations Likely Oncogenic Likely Loss-of-function 10656986, 11212236 +TGFBR1 S387Y Likely Oncogenic Loss-of-function 9809982 +TGFBR1 P83L Likely Oncogenic Loss-of-function 21358634 +TGFBR1 TGFBR1*6A Likely Oncogenic Loss-of-function 17848956, 10582683, 20429896, 16204663, 19882361, 22905183 +TGFBR2 R537P Likely Oncogenic Likely Gain-of-function 18339844 +TGFBR2 P525L Likely Oncogenic Loss-of-function 7862150 +TGFBR2 D404G Likely Oncogenic Loss-of-function 8668164 +TGFBR2 Deletion Likely Oncogenic Likely Loss-of-function 27558455, 25521327, 25736321 +TGFBR2 E526Q Likely Oncogenic Loss-of-function 18339844, 10789724 +TGFBR2 Truncating Mutations Likely Oncogenic Likely Loss-of-function 16310402, 17456004, 17985359, 9927040, 11309634, 7585632 +MSH6 T1219I Likely Oncogenic Likely Loss-of-function 11709755, 24362816, 22102614, 23621914 +MSH6 S144I Likely Neutral Likely Neutral 21120944 +MSH6 R1076C Likely Oncogenic Likely Loss-of-function 21056691, 19072991 +MSH6 Deletion Likely Oncogenic Likely Loss-of-function 25255306, 24090359, 21970482, 12019211, 22781090 +MSH6 F1088Sfs*2 Oncogenic Loss-of-function 9808525, 11474654, 19254532, 9331106 +MSH6 R1095H Likely Neutral Likely Neutral 22581703, 24040339, 12522549, 23621914 +MSH6 F1088Lfs*5 Oncogenic Loss-of-function 12732731, 11474654, 10959092, 9510473, 19254532, 21637783 +MSH6 Truncating Mutations Likely Oncogenic Likely Loss-of-function 9822680, 9111312, 1651234, 9564049 +MSH6 R976H Likely Oncogenic Likely Loss-of-function 11709755, 24362816, 11807791, 18790734 +MSH6 V509A Likely Neutral Likely Neutral 24362816 +MSH6 R922* Oncogenic Loss-of-function 24362816, 19254532 +MSH6 E946* Oncogenic Loss-of-function 12732731, 22810696, 19254532 +MSH6 E1322* Oncogenic Loss-of-function 24755471, 22810696, 19254532 +MSH6 G39E Likely Neutral Likely Neutral 24362816 +KMT2D Deletion Likely Oncogenic Likely Loss-of-function 24633898, 24240169, 26366712 +KMT2D Truncating Mutations Likely Oncogenic Likely Loss-of-function 24633898, 24240169, 26366712 +LATS1 Truncating Mutations Likely Oncogenic Loss-of-function 9988269, 23230145, 11850843 +LATS1 Deletion Likely Oncogenic Likely Loss-of-function 9988269, 23573293, 26040669 +PBRM1 Deletion Likely Oncogenic Likely Loss-of-function 18339845, 21248752, 23867514, 22949125 +PBRM1 N1333Gfs* Oncogenic Loss-of-function 25911086 +PBRM1 Truncating Mutations Likely Oncogenic Likely Loss-of-function 18339845, 24613357, 21248752, 22949125, 21654818 +SF3B1 H662D Likely Oncogenic Switch-of-function 25428262 +SF3B1 R625D Likely Oncogenic Switch-of-function 24434863 +SF3B1 G742D Likely Oncogenic Switch-of-function 24434863, 25428262, 21909114 +SF3B1 R625G Likely Oncogenic Switch-of-function 25788694, 26565915 +SF3B1 K666M Likely Oncogenic Switch-of-function 24434863 +SF3B1 R625C Likely Oncogenic Switch-of-function 24434863, 26565915, 23861464 +SF3B1 K666R Oncogenic Switch-of-function 25428262, 21909114 +SF3B1 R957Q Likely Oncogenic Switch-of-function 23160465 +SF3B1 K700R Likely Oncogenic Likely Switch-of-function 24434863, 26565915, 26619011, 25428262 +SF3B1 R625H Likely Oncogenic Switch-of-function 24434863, 26565915, 23861464 +SF3B1 H662Q Likely Oncogenic Switch-of-function 25428262, 21909114 +SF3B1 R625L Likely Oncogenic Switch-of-function 24434863, 26565915, 23861464 +SF3B1 K700E Likely Oncogenic Switch-of-function 25424858, 24434863, 26565915, 24854990, 23335386, 25428262, 23160465, 27622333, 21909114 +SF3B1 E622Q Likely Oncogenic Switch-of-function 26565915, 25428262, 21909114 +SF3B1 K666N Likely Oncogenic Switch-of-function 24434863, 25788694 +SF3B1 H662R Likely Oncogenic Switch-of-function 25428262, 21909114 +SF3B1 E622D Likely Oncogenic Switch-of-function 25428262, 21909114 +SF3B1 K666T Likely Oncogenic Switch-of-function 24434863, 26842708 +LATS2 Deletion Oncogenic Loss-of-function 21245096 +EGFR V769_D770insGVV Oncogenic Gain-of-function 23371856, 19536777, 24353160, 21764376, 18676761, 15897572, 17686547, 17192902 +EGFR L703P Likely Oncogenic Likely Gain-of-function 19020901 +EGFR S720P Likely Oncogenic Likely Gain-of-function 22760226, 15897572 +EGFR S784F Likely Oncogenic Gain-of-function 20522446, 21531810, 19147750, 21841502 +EGFR Exon 19 insertion Oncogenic Gain-of-function 21422421, 22190593 +EGFR L858Q Likely Oncogenic Likely Gain-of-function 24743239 +EGFR Exon 19 deletion Oncogenic Gain-of-function 15329413, 18000506, 15118125, 19536777, 18458038, 15118073, 22019513, 23566546, 23559152, 24457318, 22760226, 23749122, 17192902 +EGFR D770_N771insVDSVDNP Oncogenic Gain-of-function 23371856, 19536777, 24353160, 21764376, 18676761, 15897572, 21841502, 17686547 +EGFR K745_A750del Oncogenic Gain-of-function 15118073, 15329413, 25179728, 15118125 +EGFR T710A Likely Oncogenic Likely Gain-of-function 23912954 +EGFR H773dup Oncogenic Gain-of-function 24353160 +EGFR G863S Likely Oncogenic Likely Gain-of-function 18000506 +EGFR Y727H Likely Oncogenic Likely Gain-of-function 18000506 +EGFR E884K Oncogenic Gain-of-function 16407879, 19015641 +EGFR T790M Oncogenic Gain-of-function 15728811, 18227510, 15737014 +EGFR G796S Likely Oncogenic Gain-of-function 18193092 +EGFR L747V Likely Oncogenic Likely Gain-of-function 23242437, 22190593 +EGFR H773L Oncogenic Gain-of-function 17974985 +EGFR R841K Likely Neutral Likely Loss-of-function 18193092 +EGFR E746V Likely Oncogenic Likely Gain-of-function 16467085, 18000506 +EGFR S768_D770dup Oncogenic Gain-of-function 23371856, 19536777, 24353160, 21764376, 18676761, 23749122, 15897572, 17686547 +EGFR H870R Likely Neutral Likely Neutral 19671738, 21841502 +EGFR P691S Likely Oncogenic Likely Gain-of-function 22483783, 18000506 +EGFR L858M Likely Oncogenic Likely Gain-of-function 25232377 +EGFR R108K Oncogenic Gain-of-function 24120142, 17177598 +EGFR E746Q Likely Oncogenic Likely Gain-of-function 16467085 +EGFR L747_E749del Oncogenic Gain-of-function 16467085, 15118073, 15329413, 25179728, 15118125 +EGFR E709Q Likely Oncogenic Likely Gain-of-function 19671738, 15897572 +EGFR I744_K745delinsKIPVAI Oncogenic Gain-of-function 15118073, 15329413, 21841502, 15118125 +EGFR V726M Likely Oncogenic Likely Gain-of-function 18000506 +EGFR W731L Likely Oncogenic Gain-of-function 20942962 +EGFR A750_E758delinsP Oncogenic Gain-of-function 15118073, 15329413, 18261621, 15118125 +EGFR S464L Likely Oncogenic Likely Gain-of-function 25633215 +EGFR V774M Likely Oncogenic Likely Gain-of-function 21531810 +EGFR S921R Likely Neutral Inconclusive 19020901 +EGFR A763_Y764insFQEA Oncogenic Gain-of-function 24353160 +EGFR P753S Likely Oncogenic Likely Gain-of-function 16467085, 16106023, 25130612, 24934779 +EGFR N826Y Likely Oncogenic Likely Gain-of-function 21531810, 19147750 +EGFR S752_I759del Likely Oncogenic Likely Gain-of-function 23371856, 19536777, 24353160, 21764376, 18676761, 15897572, 17686547, 17192902 +EGFR E746_S752delinsI Oncogenic Gain-of-function 15118073, 15329413, 15118125, 17192902 +EGFR E709V Likely Oncogenic Likely Gain-of-function 21531810, 19536777, 26051236 +EGFR G465E Likely Oncogenic Likely Gain-of-function 26416732 +EGFR L861F Likely Oncogenic Likely Gain-of-function 21531810, 19536777, 19147750, 17177598, 26051236, 21252719 +EGFR S768I Oncogenic Gain-of-function 19536777, 16205628, 25521406, 25521405, 23242437, 19147750, 18676761, 23912954, 25179728, 25130612 +EGFR E709G Likely Oncogenic Likely Gain-of-function 21531810, 26051236, 23912954 +EGFR L747_T751del Oncogenic Gain-of-function 18325048, 23242437, 15118073, 15329413, 23387505, 15897572, 15118125 +EGFR E866K Likely Neutral Loss-of-function 19147750 +EGFR L747_S752del Oncogenic Gain-of-function 16467085, 15118073, 15329413, 15118125, 17192902 +EGFR G719S Oncogenic Gain-of-function 21531810, 16187797, 26206867 +EGFR A767_V769dup Oncogenic Gain-of-function 23371856, 19536777, 24353160, 21764376, 18676761, 23912954, 23749122, 15897572, 17686547 +EGFR L861P Likely Oncogenic Likely Gain-of-function 21531810, 17177598, 18000506 +EGFR L858R Oncogenic Gain-of-function 15118073, 15329413, 15118125 +EGFR L838P Likely Oncogenic Likely Gain-of-function 21531810 +EGFR L747P Oncogenic Gain-of-function 21531810, 18508816, 19536777, 26339441, 26001153, 22190593 +EGFR Fusions Likely Oncogenic Likely Gain-of-function 27102076, 23917401 +EGFR D761N Likely Oncogenic Gain-of-function 19147750, 26870223 +EGFR K467T Likely Oncogenic Likely Gain-of-function 25633215 +EGFR G465R Likely Oncogenic Likely Gain-of-function 26416732 +EGFR T785A Likely Oncogenic Gain-of-function 20942962 +EGFR E746_S752delinsV Oncogenic Gain-of-function 15118073, 15329413, 22483783, 25179728, 15710947, 15118125 +EGFR E330K Oncogenic Gain-of-function 24212795 +EGFR E734Q Likely Oncogenic Gain-of-function 20942962 +EGFR T725M Likely Oncogenic Gain-of-function 24743239 +EGFR D761Y Likely Oncogenic Likely Gain-of-function 17973572, 17545553, 19632948, 17085664, 17192902 +EGFR EGFRvV Oncogenic Gain-of-function 17189397, 1730638, 2790960 +EGFR EGFRvIII Oncogenic Gain-of-function 8895767, 17189397, 19324552, 8052651, 23777544, 12438278 +EGFR L861Q Oncogenic Gain-of-function 21531810, 18508816, 16467085, 17177598, 25668120, 21841502, 15897572, 21252719, 19536777, 18325048, 19147750, 26051236, 18676761, 23912954, 24457318, 22760226, 20808254, 23749122, 24285021 +EGFR P772_V774dup Oncogenic Gain-of-function 23371856, 19536777, 24353160, 21764376, 18676761, 25179728, 15897572, 17686547 +EGFR G719C Likely Oncogenic Likely Gain-of-function 21531810, 15118073, 19147750, 18261621, 26206867, 21841502 +EGFR A767_V769del Likely Oncogenic Likely Gain-of-function 23371856, 19536777, 24353160, 21764376, 18676761, 15897572, 17686547 +EGFR E746G Likely Oncogenic Likely Gain-of-function 21531810 +EGFR T34_A289del Oncogenic Gain-of-function 27216155 +EGFR G735S Oncogenic Gain-of-function 18193092, 25435280 +EGFR S768_V769insVAS Oncogenic Gain-of-function 23371856, 19536777, 24353160, 21764376, 18676761, 15897572, 21841502, 17686547 +EGFR H773insLGNP Oncogenic Gain-of-function 23371856, 19536777, 24353160, 21764376, 18676761, 23749122, 15897572, 17686547 +EGFR EGFRvII Oncogenic Gain-of-function 24893890, 17189397 +EGFR G810S Likely Oncogenic Gain-of-function 19147750 +EGFR L861R Oncogenic Gain-of-function 21531810, 17177598, 24743239, 21841502, 21252719 +EGFR R776H Likely Oncogenic Gain-of-function 23242437, 20512075, 23358982 +EGFR E746_S752delinsA Oncogenic Gain-of-function 15118073, 15329413, 15710947, 15118125 +EGFR E746_A750del Oncogenic Gain-of-function 18508816, 18325048, 16467085, 15118073, 15329413, 18261621, 22483783, 25179728, 16373402, 15710947, 15897572, 15118125 +EGFR T263P Oncogenic Gain-of-function 17177598 +EGFR G724S Oncogenic Gain-of-function 16166444, 24894453, 24743239 +EGFR S645C Likely Oncogenic Likely Gain-of-function 27478040 +EGFR H773Y Likely Oncogenic Likely Gain-of-function 19536777, 17974985, 18676761 +EGFR V843I Likely Oncogenic Gain-of-function 23380224, 21172876, 19536777, 25057940, 18000506, 18355544 +EGFR V774A Likely Oncogenic Likely Gain-of-function 21531810 +EGFR G863D Likely Oncogenic Gain-of-function 17376509, 16204011, 15897572 +EGFR S492R Likely Oncogenic Likely Switch-of-function 22270724 +EGFR Exon 19 deletion/insertion Oncogenic Gain-of-function 15329413, 18000506, 15118125, 19536777, 18458038, 15118073, 22019513, 23566546, 23559152, 24457318, 22760226, 23749122, 17192902 +EGFR C620Y Oncogenic Gain-of-function 24747966 +EGFR G857E Likely Oncogenic Likely Gain-of-function 23139256, 18000506, 19238633, 25435280 +EGFR P772_H773insYNP Oncogenic Gain-of-function 23371856, 19536777, 24353160, 21764376, 18676761, 15897572, 17686547 +EGFR A289V Oncogenic Gain-of-function 24120142, 17177598, 22588883 +EGFR D770_N771insSVD Oncogenic Gain-of-function 23371856, 19536777, 24353160, 21764376, 18676761, 15897572, 17686547 +EGFR E746_T751insIP Oncogenic Gain-of-function 18325048, 22190593 +EGFR EGFR-RAD51 Fusion Oncogenic Gain-of-function 27102076 +EGFR V742A Likely Oncogenic Gain-of-function 21531810, 23605641, 19147750, 16152581 +EGFR A864T Oncogenic Gain-of-function 23585556, 19147750, 21761100, 22722798, 16551849 +EGFR I941R Likely Neutral Likely Loss-of-function 24063894 +EGFR EGFR-KDD Oncogenic Gain-of-function 26286086 +EGFR E758G Likely Oncogenic Likely Gain-of-function 19536777 +EGFR V769M Likely Oncogenic Likely Gain-of-function 21531810, 23749122 +EGFR L704N Likely Neutral Loss-of-function 24063894 +EGFR L747S Likely Oncogenic Likely Gain-of-function 17973572, 18309959, 18645621, 19632948, 18981003 +EGFR R776C Likely Oncogenic Gain-of-function 19147750 +EGFR E746_T751delinsL Oncogenic Gain-of-function 15118073, 15329413, 18261621, 15118125 +EGFR K745M Likely Neutral Loss-of-function 21081186 +EGFR I853T Likely Neutral Loss-of-function 19147750 +EGFR P848L Likely Neutral Likely Neutral 23897956, 22848293, 25176975, 23912954, 17877814 +EGFR L747_P753del Oncogenic Gain-of-function 15118073, 15329413, 25179728, 15118125 +EGFR D770_N771insNPG Oncogenic Gain-of-function 23371856, 19536777, 24353160, 21764376, 18676761, 15897572, 17686547 +EGFR I491M Likely Oncogenic Likely Neutral 25633215 +EGFR N826S Oncogenic Gain-of-function 19147750, 15897572 +EGFR E709_T710delinsD Oncogenic Gain-of-function 21531810, 26206867 +EGFR V769_D770insASV Oncogenic Gain-of-function 23371856, 19536777, 24353160, 21764376, 18676761, 15897572, 17686547 +EGFR EGFR-PURB Fusion Likely Oncogenic Likely Gain-of-function 27102076 +EGFR L692F Likely Oncogenic Likely Gain-of-function 23912954 +EGFR E746_A750delinsQ Oncogenic Gain-of-function 15118073, 15329413, 15118125, 17192902 +EGFR G719A Oncogenic Gain-of-function 21531810, 26206867 +EGFR L747_A750del Oncogenic Gain-of-function 16467085, 15118073, 15329413, 15118125 +EGFR L838V Likely Oncogenic Gain-of-function 19147750 +EGFR E709A Likely Oncogenic Gain-of-function 21531810, 19671738, 23242437, 18261621, 23566546, 22483783, 23749122, 20479403, 15710947, 18372921, 21841502 +EGFR Exon 20 insertion Oncogenic Gain-of-function 23371856, 19536777, 24353160, 21764376, 18676761, 15897572, 17686547 +EGFR E868G Likely Oncogenic Gain-of-function 20942962, 16870303 +EGFR E746_T751delinsVA Oncogenic Gain-of-function 18508816, 15118073, 15329413, 15897572, 15118125 +EGFR E804G Likely Oncogenic Gain-of-function 18193092 +EGFR K806A Likely Oncogenic Likely Gain-of-function 19536777 +EGFR H773_V774insH Oncogenic Gain-of-function 24353160 +EGFR Y801H Likely Oncogenic Gain-of-function 20942962, 17224267 +EGFR D837N Likely Oncogenic Likely Gain-of-function 23749122 +EGFR D587H Likely Oncogenic Gain-of-function 26571394, 27245685 +EGFR N771_H773dup Oncogenic Gain-of-function 23371856, 19536777, 24353160, 21764376, 18676761, 23912954, 15897572, 17686547 +EGFR E746_T751delinsA Oncogenic Gain-of-function 15118073, 15329413, 15710947, 15897572, 15118125 +EGFR R836C Likely Oncogenic Likely Gain-of-function 23912954 +EGFR G598V Oncogenic Gain-of-function 24120142, 17177598, 22588883 +EGFR R324L Oncogenic Gain-of-function 24212795 +EGFR A750_E758del Oncogenic Gain-of-function 18325048, 15118073, 15329413, 15118125 +EGFR D770_N771insD Oncogenic Gain-of-function 23371856, 19536777, 24353160, 21764376, 18676761, 15897572, 17686547 +EGFR L747F Likely Oncogenic Likely Gain-of-function 16533793, 26773740, 24385129, 23485129, 26096169, 22190593 +EGFR L747_P753delinsS Oncogenic Gain-of-function 18508816, 15118073, 15329413, 19147750, 25179728, 15710947, 15897572, 15118125 +EGFR Amplification Oncogenic Gain-of-function 24120142, 10728703 +EGFR A859_L883delinsV Likely Oncogenic Likely Gain-of-function 18325048 +EGFR A750P Oncogenic Gain-of-function 19625781, 25179728, 15737014, 16187797 +EGFR E709K Oncogenic Gain-of-function 19726454, 23566546, 18000506, 25179728, 25130612, 23749122, 15710947, 26206867 +EGFR C797Y Likely Oncogenic Gain-of-function 20942962 +EGFR V765A Likely Oncogenic Likely Gain-of-function 15897572 +EGFR P596L Likely Oncogenic Likely Gain-of-function 17177598, 23243055 +EGFR G719D Likely Oncogenic Likely Gain-of-function 21531810, 18000506, 26206867 +EGFR L747_T751delinsP Oncogenic Gain-of-function 15118073, 15329413, 15710947, 15118125 +EGFR T783A Likely Oncogenic Likely Gain-of-function 18676761, 15897572 +EGFR L833V Oncogenic Gain-of-function 16205628, 21949883, 23912954, 25130612, 20808254, 21422421 +EGFR EGFRvIV Oncogenic Gain-of-function 20676128, 23007009 +EGFR D770_P772dup Oncogenic Gain-of-function 23371856, 19536777, 24353160, 21764376, 18676761, 23749122, 15897572, 17686547 +EGFR C628Y Likely Neutral Neutral 24747966 +EGFR L747_A750delinsP Oncogenic Gain-of-function 18508816, 15118073, 15329413, 15118125, 17192902 +EGFR V851A Likely Neutral Loss-of-function 19147750 +NKX2-1 Amplification Oncogenic Gain-of-function 17925434, 18212743, 22439932 +NKX2-1 Fusions Likely Oncogenic Likely Gain-of-function 21481790 +NKX2-1 A339V Likely Oncogenic Gain-of-function 19176457 +NKX2-1 TRB-NKX2-1 Fusion Likely Oncogenic Likely Gain-of-function 21481790 +NKX2-1 IGH-NKX2 Fusion Likely Oncogenic Likely Gain-of-function 21481790 +NKX2-1 TRA-NKX2-1 Fusion Likely Oncogenic Likely Gain-of-function 21481790 +EIF1AX A113_splice Oncogenic Gain-of-function 26878173 Krishnamoorthy et al. Abstract# 892, AACR 2016 http://cancerres.aacrjournals.org/content/76/14_Supplement/892 +ARID2 Truncating Mutations Likely Oncogenic Likely Loss-of-function 23047306, 21822264, 15985610, 16847454 +ARID2 Deletion Likely Oncogenic Likely Loss-of-function 23047306, 22095441, 15985610, 16847454 +BRD4 BRD4-NUT Fusion Oncogenic Gain-of-function 23604113, 21447744, 25512383, 20676058, 17934517, 20871596 +BRD4 Fusions Oncogenic Likely Gain-of-function 12543779, 23128391, 25564152 +BRD4 Amplification Likely Oncogenic Gain-of-function 12192049, 19596781, 15456879 +HIST1H1C S102F Likely Oncogenic Likely Loss-of-function 24362818 +ERRFI1 Deletion Likely Oncogenic Likely Loss-of-function 16648858, 21113414 +ERRFI1 Truncating Mutations Likely Oncogenic Likely Loss-of-function +CHEK2 R117G Likely Oncogenic Loss-of-function 16835864, 16982735 +CHEK2 I157T Inconclusive Inconclusive 16816021, 11571648, 15239132, 11053450, 14612911, 15492928, 11298456, 12049740 +CHEK2 H371Y Likely Oncogenic Loss-of-function 21618645, 25884806 +CHEK2 E321K Likely Oncogenic Loss-of-function 16835864 +CHEK2 K373E Oncogenic Loss-of-function 27716909 +CHEK2 S428F Likely Oncogenic Likely Loss-of-function 16998506, 15649950 +CHEK2 P85L Likely Neutral Neutral 16998506, 15649950 +CHEK2 E161del Likely Oncogenic Loss-of-function 16982735 +PAK1 Amplification Oncogenic Gain-of-function 21482786, 22105362 +TMPRSS2 TMPRSS2-ERG Fusion Oncogenic Gain-of-function 7731694, 16213704, 17043636 +TMPRSS2 Fusions Likely Oncogenic Likely Gain-of-function 16254181, 18283340 +TMPRSS2 T75M Likely Neutral Neutral 11745466, 25040002 +TMPRSS2 TMPRSS2-ETV5 Fusion Likely Oncogenic Likely Gain-of-function 18172298 +TMPRSS2 TMPRSS2-ETV4 Fusion Likely Oncogenic Likely Gain-of-function 16585160 +TMPRSS2 M160V Likely Neutral Neutral 11745466, 25040002 +TMPRSS2 TMPRSS2-ETV1 Fusion Oncogenic Gain-of-function 18563191, 23512661 +H3F3A K28M Likely Oncogenic Likely Switch-of-function 21685365, 22286061 +H3F3A G35V Likely Oncogenic Likely Switch-of-function 21685365, 23079654, 22286061 +H3F3A G35R Likely Oncogenic Likely Switch-of-function 21685365, 23079654, 22286061 +ELF3 I279P Likely Oncogenic Likely Loss-of-function 17148437 +ELF3 Truncating Mutations Likely Oncogenic Likely Loss-of-function 14976186, 17148437 +ELF3 K320E Likely Neutral Likely Neutral 17148437 +ELF3 A312P Likely Oncogenic Likely Loss-of-function 17148437 +ELF3 S330A Likely Neutral Likely Neutral 17148437 +ELF3 S308A Likely Neutral Likely Neutral 17148437 +ELF3 R331P Likely Oncogenic Likely Loss-of-function 17148437 +ROS1 S1986F Likely Oncogenic Likely Gain-of-function 27401242 +ROS1 ROS1-CD74 Fusion Oncogenic Gain-of-function 22919003, 22215748, 18083107, 22327623 +ROS1 CEP85L-ROS1 Fusion Likely Oncogenic Likely Gain-of-function 25204415, 23637631 +ROS1 E1935G Likely Oncogenic Likely Gain-of-function 24218589 +ROS1 FIG-ROS1 Fusion Oncogenic Gain-of-function 12661006, 2827175 +ROS1 G2101A Likely Oncogenic Likely Gain-of-function 22235099, 25688157, 24675041 +ROS1 KDELR2-ROS1 Fusion Likely Oncogenic Likely Gain-of-function 22980976 +ROS1 G1971E Likely Oncogenic Likely Gain-of-function 24218589 +ROS1 D2033N Likely Oncogenic Likely Gain-of-function 26673800 +ROS1 L1951R Inconclusive Inconclusive 25351743 +ROS1 C2060G Likely Oncogenic Likely Gain-of-function 24218589 +ROS1 SLC34A2-ROS1 Fusion Oncogenic Gain-of-function 22919003, 22215748, 22327623 +ROS1 TPM3-ROS1 Fusion Oncogenic Gain-of-function 22327623 +ROS1 TFG-ROS1 Fusion Likely Oncogenic Likely Gain-of-function 24875859 +ROS1 S1986Y Likely Oncogenic Likely Gain-of-function 27401242 +ROS1 G2032R Likely Oncogenic Likely Gain-of-function 25351743, 24047073, 24047072, 23724914, 27401242, 25688157 +ROS1 Fusions Likely Oncogenic Likely Gain-of-function 22919003, 23719267, 22215748 +ROS1 CD74-ROS1 Fusion Oncogenic Gain-of-function 22919003, 22215748, 18083107, 22327623 +ROS1 YWHAE-ROS1 Fusion Likely Oncogenic Likely Gain-of-function 24875859 +ROS1 LIMA1-ROS1 Fusion Likely Oncogenic Likely Gain-of-function 25264305 +ROS1 MSN-ROS1 Fusion Likely Oncogenic Likely Gain-of-function 25264305 +ROS1 EZR-ROS1 Fusion Oncogenic Gain-of-function 22327623 +ROS1 LRIG3-ROS1 Fusion Oncogenic Gain-of-function 22327623 +ROS1 Amplification Likely Oncogenic Likely Gain-of-function 25978031 +ROS1 V2098I Likely Oncogenic Likely Gain-of-function 24218589 +ROS1 SDC4-ROS1 Fusion Oncogenic Gain-of-function 22327623 +ROS1 L1947R Likely Oncogenic Likely Gain-of-function 24218589 +ROS1 CCDC6-ROS1 Fusion Likely Oncogenic Likely Gain-of-function 22975805, 25870798 +ASXL2 Truncating Mutations Likely Oncogenic Likely Loss-of-function 24973361 Li et al. Abstract# 1509, ASH 2016 http://www.bloodjournal.org/content/128/22/1509 +ASXL2 Deletion Likely Oncogenic Likely Loss-of-function 24973361 Li et al. Abstract# 1509, ASH 2016 http://www.bloodjournal.org/content/128/22/1509 +CDH1 D257N Likely Oncogenic Likely Loss-of-function 24690483 +CDH1 R732Q Likely Oncogenic Likely Loss-of-function 15235021, 17545690 +CDH1 T340A Oncogenic Loss-of-function 12588804 +CDH1 Deletion Likely Oncogenic Likely Loss-of-function 23812922, 2070412, 23341533, 19168852, 9515965, 24037103 +CDH1 Epigenetic Silencing Likely Oncogenic Likely Loss-of-function 11313896, 7543680 +CDH1 A617T Likely Oncogenic Loss-of-function 12588804 +CDH1 A634V Oncogenic Loss-of-function 12588804 +CDH1 D254N Oncogenic Loss-of-function 26123647 +CDH1 Truncating Mutations Likely Oncogenic Likely Loss-of-function 8934538, 2070412, 9515965, 17522512 +CDH1 A298T Likely Oncogenic Likely Loss-of-function 24204729 +EPCAM 3' Deletion Oncogenic Loss-of-function 21145788 +TOP1 Truncating Mutations Likely Oncogenic Likely Loss-of-function +EP300 EP300-MLL Fusion Likely Oncogenic Gain-of-function 18778367, 23307074, 9389684, 20980053 +EP300 Deletion Likely Oncogenic Likely Loss-of-function 10700188, 12402157, 12237408 +EP300 Fusions Likely Oncogenic Likely Gain-of-function 25943178, 26293203, 23307074 +EP300 Truncating Mutations Likely Oncogenic Likely Loss-of-function 10700188, 15156177, 12402157, 12237408 +EP300 D1399Y Likely Oncogenic Loss-of-function 12586840, 25151357 +EP300 P1502L Likely Oncogenic Loss-of-function 25151357 +EP300 C1385 Likely Oncogenic Loss-of-function 18273021 +EP300 EP300-MOZ Fusion Likely Oncogenic Gain-of-function 10824998, 23307074, 11243405 +EP300 Y1414C Likely Oncogenic Loss-of-function 25151357 +EP300 R1627 Likely Oncogenic Loss-of-function 18273021 +EPAS1 P531A Likely Oncogenic Likely Gain-of-function 23054256, 14691554, 12086860 +EPAS1 533_534del Likely Oncogenic Likely Gain-of-function 22931260, 23418310 +EPAS1 Y532C Likely Oncogenic Likely Gain-of-function 23361906, 23653463 +EPAS1 A530V Likely Oncogenic Likely Gain-of-function 22931260, 23418310 +EPAS1 A530T Likely Oncogenic Likely Gain-of-function 22931260, 23418310 +EPAS1 P531S Likely Oncogenic Likely Gain-of-function 22931260, 23418310 +EPAS1 P531L Likely Oncogenic Likely Gain-of-function 22931260, 23418310 +EPAS1 534_536del Likely Oncogenic Likely Gain-of-function 22931260, 23418310 +TP53 H179Q Likely Oncogenic Loss-of-function 22540896 +TP53 I255F Likely Oncogenic Likely Loss-of-function 25408419 +TP53 R158C Likely Oncogenic Likely Loss-of-function 17947339 +TP53 H179R Likely Oncogenic Loss-of-function 17361096, 22427690 +TP53 C238F Likely Oncogenic Loss-of-function 20407015 +TP53 G334R Likely Neutral Neutral 25584008 +TP53 R282W Likely Oncogenic Likely Loss-of-function 21445056 +TP53 H168N Likely Oncogenic Likely Loss-of-function 19462533 +TP53 S215G Oncogenic Loss-of-function 17724467, 8023157, 26619011, 22862161, 11900253 +TP53 G266R Likely Oncogenic Loss-of-function 16827139 +TP53 P219S Likely Oncogenic Loss-of-function 10229196, 25584008 +TP53 F338I Likely Oncogenic Likely Loss-of-function 19454241, 20978130 +TP53 R110L Likely Oncogenic Likely Loss-of-function 21445056, 16778209 +TP53 Truncating Mutations Likely Oncogenic Likely Loss-of-function 19336573, 27759562, 16007150, 11753428, 11900253, 21467160 +TP53 P153H Likely Oncogenic Likely Loss-of-function 15781620, 8023157, 11900253 +TP53 Y236C Likely Oncogenic Loss-of-function 16827139 +TP53 Q331H Likely Oncogenic Likely Loss-of-function 26619011, 20978130 +TP53 L330H Likely Oncogenic Likely Loss-of-function 19454241, 20978130 +TP53 L348F Likely Oncogenic Likely Loss-of-function 19454241 +TP53 V197E Likely Oncogenic Likely Loss-of-function 25408419 +TP53 R248L Likely Oncogenic Likely Loss-of-function 26748848, 25584008 +TP53 G244S Oncogenic Loss-of-function 26818906 +TP53 S121F Likely Oncogenic Likely Gain-of-function 15781620 +TP53 R283Q Likely Oncogenic Likely Loss-of-function 7651437 +TP53 C135S Likely Oncogenic Likely Loss-of-function 17914575, 8023157, 11900253 +TP53 K120E Oncogenic Loss-of-function 18524770, 24814347, 17189187 +TP53 R273G Likely Oncogenic Likely Loss-of-function 24677579, 26619011 +TP53 K120M Oncogenic Loss-of-function 17189187 +TP53 R248W Likely Oncogenic Loss-of-function 18762571, 10229196, 25584008 +TP53 H233N Likely Oncogenic Likely Loss-of-function 19462533, 26619011 +TP53 I251S Likely Oncogenic Likely Loss-of-function 26748848 +TP53 R290G Likely Oncogenic Likely Loss-of-function 15781620, 8023157, 26619011, 11900253 +TP53 R280K Oncogenic Loss-of-function 24714748 +TP53 R181H Likely Oncogenic Loss-of-function 20471942 +TP53 C277Q Likely Oncogenic Likely Loss-of-function 7651437 +TP53 H179L Oncogenic Loss-of-function 23150443 +TP53 G266E Likely Oncogenic Likely Loss-of-function 17724467 +TP53 G244R Oncogenic Loss-of-function 11160722 +TP53 Y234C Likely Oncogenic Loss-of-function 10229196, 26748848, 16861262 +TP53 T123A Likely Neutral Likely Neutral 16687402, 18996393 +TP53 K292T Likely Oncogenic Likely Loss-of-function 15781620, 8023157, 26619011, 11900253 +TP53 C176R Likely Oncogenic Loss-of-function 8633021 +TP53 S241F Likely Oncogenic Likely Loss-of-function 21383700 +TP53 F341C Likely Oncogenic Likely Loss-of-function 19454241, 20978130 +TP53 L145R Oncogenic Loss-of-function 8023157, 11900253 +TP53 R337L Likely Oncogenic Likely Loss-of-function 19454241, 20978130, 11481490 +TP53 R175C Likely Oncogenic Likely Loss-of-function 9632751, 26619011, 22955915 +TP53 C135R Likely Oncogenic Loss-of-function 17914575 +TP53 K120R Likely Oncogenic Loss-of-function 7651437, 17189187 +TP53 C238S Likely Oncogenic Loss-of-function 19681600 +TP53 I254T Oncogenic Loss-of-function 25584008 +TP53 S241T Likely Oncogenic Loss-of-function 11896595 +TP53 S121Y Inconclusive Inconclusive 15781620 +TP53 R175H Oncogenic Loss-of-function 15781620, 10713666, 21445056, 25584008, 22114072 +TP53 H179Y Likely Oncogenic Loss-of-function 17530187 +TP53 R248Q Likely Oncogenic Likely Loss-of-function 24814347, 21445056, 16778209 +TP53 R181L Likely Oncogenic Likely Loss-of-function 20471942 +TP53 H193N Likely Oncogenic Loss-of-function 19462533 +TP53 R213Q Likely Oncogenic Loss-of-function 10871862 +TP53 A347T Likely Oncogenic Likely Loss-of-function 19454241, 20978130 +TP53 R156C Likely Oncogenic Likely Loss-of-function 15781620, 8023157, 11900253 +TP53 P278A Likely Oncogenic Likely Loss-of-function 24076587 +TP53 N239S Oncogenic Loss-of-function 22553460 +TP53 V272M Likely Oncogenic Likely Loss-of-function 15037740, 11870884 +TP53 S121A Likely Neutral Likely Gain-of-function 15781620 +TP53 G356A Inconclusive Inconclusive 20978130 +TP53 H179N Likely Oncogenic Likely Loss-of-function 19462533 +TP53 P47S Likely Neutral Neutral 25584008 +TP53 R282Q Likely Oncogenic Likely Loss-of-function 18453682 +TP53 Y163C Likely Oncogenic Loss-of-function 8023157, 23246812, 15037740, 25584008, 11900253, 15077194 +TP53 S121C Inconclusive Inconclusive 15781620 +TP53 H214Q Likely Oncogenic Likely Loss-of-function 15781620, 26619011 +TP53 S240R Likely Oncogenic Likely Loss-of-function 10229196 +TP53 Y234H Likely Oncogenic Loss-of-function 22710932 +TP53 Y236S Likely Oncogenic Loss-of-function 11429705 +TP53 R337H Likely Oncogenic Likely Loss-of-function 19454241, 25584008, 11481490 +TP53 G245S Oncogenic Loss-of-function 2358418, 15037740 +TP53 P151H Likely Oncogenic Likely Loss-of-function 8023157, 22908277, 11900253 +TP53 R248K Likely Oncogenic Likely Loss-of-function 7651437 +TP53 K291E Likely Oncogenic Likely Loss-of-function 15781620, 8023157, 26619011, 11900253 +TP53 R273H Oncogenic Loss-of-function 26181206, 15037740, 25584008 +TP53 H214R Likely Oncogenic Likely Loss-of-function 20407015, 26619011 +TP53 Y236D Likely Oncogenic Loss-of-function 8633021 +TP53 Deletion Likely Oncogenic Likely Loss-of-function 26982726, 27759562, 19477430, 11900253, 12584563 +TP53 DNA binding domain deletions Oncogenic Loss-of-function 8023157, 11900253 +TP53 A161T Likely Oncogenic Likely Loss-of-function 21232794, 16827139 +TP53 P151S Oncogenic Loss-of-function 2857548 +TP53 S215C Likely Oncogenic Likely Loss-of-function 15781620, 26619011, 12917626 +TP53 H297N Likely Neutral Likely Neutral 19462533 +TP53 L344P Likely Oncogenic Loss-of-function 19454241, 20978130, 19106109 +TP53 Q331R Likely Oncogenic Likely Loss-of-function 20978130 +TP53 L330R Likely Oncogenic Likely Loss-of-function 19454241, 20978130 +TP53 R249S Likely Oncogenic Likely Loss-of-function 21445056, 18996393, 14741214 +TP53 K120A Likely Oncogenic Likely Loss-of-function 24814347, 16687402 +TP53 P316L Likely Oncogenic Likely Loss-of-function 10618702, 2553699, 20010306 +TP53 F212Y Inconclusive Inconclusive 15781620 +TP53 G199R Likely Oncogenic Likely Loss-of-function 10229196 +TP53 P250L Likely Oncogenic Likely Loss-of-function 21445056 +TP53 Y220C Oncogenic Loss-of-function 23315175, 15037740, 23630318 +TP53 DNA binding domain missense mutations Oncogenic Loss-of-function 8023157, 11900253 +TP53 G244D Likely Oncogenic Likely Loss-of-function 12901798 +TP53 C229R Likely Oncogenic Likely Loss-of-function 25584008 +TP53 C242Y Likely Oncogenic Loss-of-function 20407015 +TP53 V197L Likely Oncogenic Likely Loss-of-function 11668476 +TP53 R181C Likely Oncogenic Loss-of-function 10229196, 20471942 +TP53 G245D Likely Oncogenic Likely Loss-of-function 25119136, 22803791, 22214764 +TP53 R337C Likely Oncogenic Loss-of-function 19454241, 17311302, 16007150, 19106109, 11753428 +TP53 C242S Likely Oncogenic Loss-of-function 20407015 +TP53 C141Y Likely Oncogenic Likely Loss-of-function 15037740 +TP53 DNA binding domain insertions Oncogenic Loss-of-function 8023157, 11900253 +TP53 K292I Likely Oncogenic Likely Gain-of-function 15781620, 8023157, 11900253 +TP53 V173L Likely Oncogenic Loss-of-function 15037740 +TP53 Y220S Likely Oncogenic Loss-of-function 15977174 +TP53 H193R Likely Oncogenic Likely Loss-of-function 9627118 +TP53 R342P Likely Oncogenic Loss-of-function 19454241, 20978130 +TP53 C277W Likely Oncogenic Likely Loss-of-function 24814347 +TP53 F328V Likely Oncogenic Likely Loss-of-function 19454241 +TP53 V173E Likely Oncogenic Loss-of-function 9472631 +TP53 R156H Likely Oncogenic Loss-of-function 10435620 +TP53 R158H Likely Oncogenic Loss-of-function 10229196, 25584008 +TP53 R273L Likely Oncogenic Loss-of-function 8023157, 15037740, 11900253 +TP53 V274F Likely Oncogenic Likely Loss-of-function 12782597 +TP53 V157D Oncogenic Loss-of-function 23981578 +TP53 K291Q Likely Oncogenic Likely Loss-of-function 15781620, 8023157, 11900253 +TP53 S241Y Likely Oncogenic Loss-of-function 25584008 +TP53 E285K Likely Oncogenic Likely Loss-of-function 20407015 +TP53 P151A Likely Oncogenic Loss-of-function 20407015 +TP53 R280T Likely Oncogenic Likely Loss-of-function 22999923 +TP53 P278L Likely Oncogenic Loss-of-function 16861262 +TP53 E258V Likely Oncogenic Likely Loss-of-function 21445056 +TP53 E285V Oncogenic Loss-of-function 18762572, 25584008 +TP53 T329I Inconclusive Inconclusive 20978130 +TP53 L330P Likely Oncogenic Likely Loss-of-function 20978130 +TP53 M237K Likely Oncogenic Likely Loss-of-function 20505364 +TP53 R158L Likely Oncogenic Loss-of-function 15037740, 25584008, 16861262 +TP53 R290H Likely Oncogenic Likely Loss-of-function 10435620 +TP53 R273C Likely Oncogenic Likely Loss-of-function 15037740, 23863845, 11900253, 23612969 +TP53 E221Q Inconclusive Inconclusive 15781620 +TP53 H115N Inconclusive Inconclusive 19462533 +TP53 R249W Oncogenic Loss-of-function 23612969 +TP53 I162M Likely Oncogenic Likely Loss-of-function 15781620, 8023157, 11900253 +TP53 K120N Likely Oncogenic Loss-of-function 7651437 +TP53 V157F Likely Oncogenic Likely Loss-of-function 21561095, 15037740, 16778209 +TP53 R337P Likely Oncogenic Likely Loss-of-function 19454241, 20978130, 11481490 +TP53 Q144R Likely Oncogenic Likely Loss-of-function 15781620, 8023157, 26619011, 11900253 +TP53 H168R Likely Oncogenic Loss-of-function 18996393 +TP53 I195T Likely Oncogenic Likely Loss-of-function 8023157, 11900253, 12700230 +TP53 V143A Likely Oncogenic Likely Loss-of-function 10435620 +TP53 P278R Likely Oncogenic Loss-of-function 21760996 +TP53 C277R Likely Oncogenic Likely Loss-of-function 7651437 +TP53 R110P Likely Oncogenic Likely Loss-of-function 21445056 +TP53 P278S Likely Oncogenic Loss-of-function 22989750 +TP53 Q144P Likely Oncogenic Likely Loss-of-function 10229196 +TP53 E286K Likely Oncogenic Loss-of-function 15037740 +TP53 G245A Likely Oncogenic Likely Loss-of-function 20589832 +TP53 R249M Likely Oncogenic Loss-of-function 17999388, 15037740 +TP53 H193P Likely Oncogenic Loss-of-function 25584008 +TP53 M133T Likely Oncogenic Likely Loss-of-function 21311097 +TP53 R175L Likely Oncogenic Loss-of-function 15781620, 18762572, 25584008 +TP53 N235D Oncogenic Loss-of-function 25584008 +TP53 V272L Likely Oncogenic Likely Loss-of-function 20407015, 26619011 +TP53 R202S Likely Oncogenic Likely Loss-of-function 10229196 +TP53 T150I Likely Oncogenic Likely Loss-of-function 10229196 +TP53 R280A Likely Oncogenic Likely Loss-of-function 18524770, 24814347, 17189187 +TP53 A161S Likely Oncogenic Loss-of-function 25119136 +TP53 L344R Likely Oncogenic Likely Loss-of-function 19454241, 20978130 +TP53 D186A Likely Oncogenic Likely Loss-of-function 24814347 +TP53 E326L Likely Oncogenic Loss-of-function 26748848 +TP53 R267Q Likely Oncogenic Likely Loss-of-function 10435620, 25584008 +TP53 V218dup Oncogenic Loss-of-function 8023157, 11900253 +TP53 C275S Likely Oncogenic Loss-of-function 25584637 +TP53 L348S Likely Oncogenic Likely Loss-of-function 20978130 +TP53 C242F Likely Oncogenic Likely Loss-of-function 17401432 +TP53 C176F Likely Oncogenic Loss-of-function 22090360 +TP53 H214N Likely Oncogenic Likely Loss-of-function 19462533 +TP53 R267P Likely Oncogenic Likely Gain-of-function 23264849, 22989750 +TP53 C135Y Likely Oncogenic Switch-of-function 22847613 +TP53 G245C Likely Oncogenic Likely Loss-of-function 15037740, 22803791 +TP53 E180K Likely Oncogenic Loss-of-function 24814347, 20471942 +TP53 R273K Likely Oncogenic Loss-of-function 7651437 +TP53 F134Y Likely Oncogenic Likely Loss-of-function 26619011, 25584008 +TP53 P152L Likely Oncogenic Likely Loss-of-function 25584008 +TP53BP1 Truncating Mutations Likely Oncogenic Likely Loss-of-function 23103855 +TP53BP1 Deletion Likely Oncogenic Likely Loss-of-function 16260621, 22915756 +SMAD2 Deletion Likely Oncogenic Loss-of-function 15133179, 20010874, 16382155, 18618014, 12384562, 22204491, 19276350, 20852387 +SMAD2 F346V Likely Neutral Likely Neutral 11274206 +SMAD2 D450E Likely Oncogenic Likely Loss-of-function 23139211 +SMAD2 R310H Likely Oncogenic Likely Loss-of-function 11274206 +SMAD2 T413N Likely Oncogenic Likely Loss-of-function 23139211 +SMAD2 R428A Inconclusive Inconclusive 11779503 +SMAD2 N387P Inconclusive Inconclusive 11779503 +SMAD2 V319D Likely Oncogenic Likely Loss-of-function 11274206 +SMAD2 Y426A Likely Oncogenic Likely Loss-of-function 11779503, 9463378 +SMAD2 K375A Inconclusive Inconclusive 11779503 +SMAD2 S276L Likely Oncogenic Likely Loss-of-function 23139211 +SMAD2 S467P Likely Oncogenic Likely Loss-of-function 23139211 +SMAD2 K420A Likely Oncogenic Likely Loss-of-function 14729957, 11779503 +SMAD2 Y406H Inconclusive Inconclusive 11779503 +SMAD2 W368H Likely Neutral Likely Neutral 11274206, 11779503 +SMAD2 D300H Likely Oncogenic Likely Loss-of-function 11274206, 11779503 +SMAD2 D450H Likely Oncogenic Likely Loss-of-function 11779503 +SMAD2 R321Q Likely Oncogenic Loss-of-function 16828225, 20937913 +SMAD2 P305L Likely Oncogenic Likely Loss-of-function 23139211 +SMAD2 Truncating Mutations Likely Oncogenic Likely Loss-of-function 12894231, 23139211, 15711891, 11779503 +SMAD2 D300N Likely Oncogenic Likely Loss-of-function 23139211 +SMAD3 Truncating Mutations Likely Oncogenic Likely Loss-of-function 11691834 +SMAD3 Y297A Likely Oncogenic Likely Loss-of-function 21949838 +SMAD3 W406A Likely Oncogenic Likely Loss-of-function 21949838 +SMAD3 R292A Likely Oncogenic Likely Loss-of-function 21949838 +SMAD3 K341A Likely Oncogenic Likely Loss-of-function 21949838 +SMAD3 D258N Likely Oncogenic Loss-of-function 23139211 +SMAD3 D408H Likely Oncogenic Loss-of-function 21949838 +SMAD3 Y298A Likely Oncogenic Likely Loss-of-function 21949838 +SMAD3 R268A Likely Oncogenic Loss-of-function 21949838 +SMAD3 Y238A Likely Oncogenic Likely Loss-of-function 21949838 +SMAD3 D408Y Likely Oncogenic Loss-of-function 23139211 +SMAD3 P336S Likely Oncogenic Loss-of-function 23139211 +SMAD3 Deletion Likely Oncogenic Likely Loss-of-function 14647420, 18852474, 9753318, 16951153 +SMAD3 R373H Likely Oncogenic Likely Loss-of-function 16828225 +SMAD3 Y226A Likely Oncogenic Likely Loss-of-function 21949838 +SMAD3 Y237A Likely Neutral Neutral 17994767 +SMAD3 R373Q Likely Oncogenic Loss-of-function 23139211 +SMAD3 R287A Likely Oncogenic Loss-of-function 17994767 +SMAD3 D408E Likely Oncogenic Loss-of-function 10092624 +SMAD3 V356R Likely Oncogenic Likely Loss-of-function 21949838 +SMAD3 S425C Likely Oncogenic Loss-of-function 23139211 +SMAD3 Y384A Likely Oncogenic Likely Loss-of-function 21949838 +SMAD3 E239A Likely Oncogenic Loss-of-function 17994767 +SMAD3 V277D Likely Oncogenic Loss-of-function 10092624 +SMAD3 R243A Likely Oncogenic Likely Loss-of-function 21949838 +SMAD4 P130S Likely Oncogenic Loss-of-function 14647410 +SMAD4 E330A Likely Oncogenic Loss-of-function 17994767 +SMAD4 W398V Inconclusive Inconclusive 11274206 +SMAD4 L43V Likely Oncogenic Likely Loss-of-function 14647410 +SMAD4 C324Y Likely Oncogenic Likely Loss-of-function 22109972 +SMAD4 P102L Likely Oncogenic Likely Loss-of-function 14647410 +SMAD4 R441P Likely Neutral Likely Neutral 11274206, 11779503, 10822381 +SMAD4 Deletion Likely Oncogenic Loss-of-function 22321641, 25893305, 9482899, 10626800, 9506519, 17114584, 19841536, 10773876 +SMAD4 D493H Likely Oncogenic Loss-of-function 11274206, 19139564 +SMAD4 R378A Likely Oncogenic Likely Loss-of-function 15350224 +SMAD4 K507Q Likely Oncogenic Likely Loss-of-function 14647410 +SMAD4 Truncating Mutations Likely Oncogenic Likely Loss-of-function 23139211, 10340381, 15711891, 9094310, 11553622 +SMAD4 E330K Likely Oncogenic Loss-of-function 26488212 +SMAD4 R420H Likely Oncogenic Likely Neutral 11274206, 11779503 +SMAD4 R100T Likely Oncogenic Loss-of-function 14647410, 10092624 +SMAD4 R515A Likely Oncogenic Loss-of-function 11779503 +SMAD4 D357Y Likely Oncogenic Loss-of-function 14715079 +SMAD4 W509R Inconclusive Inconclusive 22316667 +SMAD4 K507A Likely Oncogenic Likely Loss-of-function 11779503 +SMAD4 R515G Likely Oncogenic Loss-of-function 14647410 +SMAD4 G419V Likely Oncogenic Loss-of-function 26488212 +SMAD4 D537E Likely Oncogenic Loss-of-function 9214508, 23139211, 14715079 +SMAD4 Y513A Inconclusive Inconclusive 11779503 +SMAD4 H132Y Likely Oncogenic Likely Loss-of-function 25275298 +SMAD4 E330G Likely Oncogenic Likely Loss-of-function 22316667 +SMAD4 R361C Likely Oncogenic Loss-of-function 9214508, 14647410, 26488212, 10092624 +SMAD4 K428A Likely Oncogenic Likely Loss-of-function 11779503 +SMAD4 D537Y Oncogenic Loss-of-function 23139211, 14715079 +SMAD4 V370D Likely Oncogenic Likely Loss-of-function 9214508, 11274206, 10092624, 19139564, 11779503 +SMAD4 R497H Likely Oncogenic Loss-of-function 14647410 +SMAD4 Y353L Likely Oncogenic Likely Loss-of-function 26619011 +SMAD4 D351H Likely Oncogenic Loss-of-function 9214508, 14647410, 11274206, 11779503, 14715079 +SMAD4 G508S Likely Oncogenic Likely Loss-of-function 9214508, 9153220 +SMAD4 D493A Likely Oncogenic Likely Loss-of-function 15350224 +SMAD4 R496H Likely Oncogenic Loss-of-function 26488212 +SMAD4 A532H Likely Oncogenic Loss-of-function 11274206 +SMAD4 V465M Inconclusive Inconclusive 22316667 +CDK4 R24C Oncogenic Gain-of-function 11606789, 11756559 +CDK4 Amplification Oncogenic Gain-of-function 20534551, 8101826, 10970848 +CDK4 K22A Oncogenic Gain-of-function 9426066, 9712735, 9228064 +AURKB Overexpression Likely Oncogenic Likely Gain-of-function 17344846, 26240282, 18347165, 16222316 +AURKB Amplification Likely Oncogenic Likely Gain-of-function 26240282 +CDK6 Amplification Oncogenic Gain-of-function 17989712, 23127611, 11940479, 20534551, 24736461, 22476749, 12900351, 19145199, 24764564 +CDK6 A197T Likely Neutral Loss-of-function 23918663 +FBXW7 G423R Likely Oncogenic Likely Loss-of-function 24838835, 26619011 +FBXW7 R505L Oncogenic Loss-of-function 17646409 +FBXW7 K11R Likely Oncogenic Likely Loss-of-function 20815813 +FBXW7 S462Y Likely Neutral Likely Neutral 27147599 +FBXW7 R465H Likely Oncogenic Loss-of-function 27147599, 24912918, 23228967, 17575125, 22608923 +FBXW7 D520N Likely Oncogenic Likely Loss-of-function 11565034, 19420964 +FBXW7 S562L Likely Neutral Neutral 24838835 +FBXW7 Truncating Mutations Likely Oncogenic Likely Loss-of-function 17646409, 15103331, 18094723 +FBXW7 R505C Oncogenic Loss-of-function 27147599, 17646408, 17575125, 23228967, 24838835, 22608923, 23095493 +FBXW7 S227A Likely Oncogenic Loss-of-function 21620836 +FBXW7 Deletion Likely Oncogenic Likely Loss-of-function 25314076, 27764699, 18367647, 15103331 +FBXW7 R479H Likely Oncogenic Loss-of-function 17575125 +FBXW7 R658Q Likely Oncogenic Likely Loss-of-function 27147599, 26619011 +FBXW7 I347M Likely Neutral Likely Neutral 27147599 +FBXW7 T205A Likely Neutral Likely Gain-of-function 22608923 +FBXW7 R465C Oncogenic Loss-of-function 17646408, 17909001, 17646409, 23095493 +FBXW7 R479Q Oncogenic Loss-of-function 17646408, 17909001, 23228967, 17646409 +FBXW7 R689Q Likely Oncogenic Likely Loss-of-function 27147599, 26619011 +FBXW7 R479L Likely Oncogenic Loss-of-function 24912918, 22608923 +FBXW7 R482Q Oncogenic Loss-of-function 23676439 +FBXW7 Copy Number Loss Oncogenic Loss-of-function 19739118, 24884509, 18367647, 18094723, 25555218, 22673505 +CDK8 Amplification Oncogenic Gain-of-function 18794900 +CDKN1A S31R Inconclusive Inconclusive 7655464, 20127253, 18046503, 17293864 +CDKN1A Truncating Mutations Likely Oncogenic Likely Loss-of-function 23159848, 24317508 +CDKN1A Deletion Likely Oncogenic Likely Loss-of-function 19106607, 25483104, 23624841, 15960923 +CDKN1B Deletion Oncogenic Loss-of-function 8646779, 23460367, 18073348, 21422114 +CDKN1B P133T Likely Oncogenic Likely Loss-of-function 21289244 +CDKN1B Truncating Mutations Likely Oncogenic Likely Loss-of-function 23555276, 8646779, 22129891, 21423803, 20492666, 25416039 +CDKN1B G9R Likely Oncogenic Loss-of-function 21289244 +CDKN1B V109G Inconclusive Inconclusive 22823061, 23652671 +CDKN2A D74N Oncogenic Loss-of-function 10491434, 19260062 +CDKN2A P81T Oncogenic Loss-of-function 20340136, 19260062, 10389768 +CDKN2A E69G Oncogenic Loss-of-function 20340136, 19260062 +CDKN2A D108H Likely Oncogenic Likely Loss-of-function 12606942 +CDKN2A D84V Oncogenic Loss-of-function 10491434 +CDKN2A R79P Oncogenic Loss-of-function 7647780 +CDKN2A R87W Oncogenic Loss-of-function 10491434, 19260062 +CDKN2A N71I Oncogenic Loss-of-function 20340136 +CDKN2A R112G Oncogenic Loss-of-function 20340136 +CDKN2A Deletion Oncogenic Loss-of-function 24071852, 9516223 +CDKN2A P81L Oncogenic Loss-of-function 20340136, 19260062, 10389768 +CDKN2A L32P Oncogenic Loss-of-function 20340136 +CDKN2A H83N Likely Oncogenic Loss-of-function 9660926 +CDKN2A N71S Oncogenic Loss-of-function 10491434 +CDKN2A L97R Oncogenic Loss-of-function 20340136, 19260062 +CDKN2A L16P Oncogenic Loss-of-function 20340136 +CDKN2A P114L Oncogenic Loss-of-function 19260062, 8755727 +CDKN2A G35A Likely Oncogenic Loss-of-function 20340136, 19260062 +CDKN2A D84H Likely Oncogenic Loss-of-function 8755727, 10498896 +CDKN2A A60R Oncogenic Loss-of-function 20340136, 19260062 +CDKN2A T77P Oncogenic Loss-of-function 19260062 +CDKN2A S56I Oncogenic Loss-of-function 20340136 +CDKN2A P73L Oncogenic Loss-of-function 7647780 +CDKN2A R99P Oncogenic Loss-of-function 20340136, 19260062 +CDKN2A G101W Oncogenic Loss-of-function 10491434, 20340136, 19260062, 8755727 +CDKN2A Q50P Oncogenic Loss-of-function 14508519 +CDKN2A G67S Oncogenic Loss-of-function 20340136, 19260062 +CDKN2A R80L Oncogenic Loss-of-function 10491434 +CDKN2A R80P Likely Oncogenic Likely Loss-of-function 10491434 +CDKN2A Q50* Oncogenic Loss-of-function 7987387 +CDKN2A R87P Oncogenic Loss-of-function 10491434, 19260062, 9607312 +CDKN2A D84Y Oncogenic Loss-of-function 10498896 +CDKN2A H83Y Oncogenic Loss-of-function 10491434, 9324288 +CDKN2A N71K Oncogenic Loss-of-function 20340136 +CDKN2A Truncating Mutations Likely Oncogenic Likely Loss-of-function 20340136, 9324288, 8603820 +CDKN2A A60V Likely Oncogenic Loss-of-function 20340136, 19260062 +CDKN2A D84N Likely Oncogenic Loss-of-function 8755727, 7777061, 10498896 +CDKN2A G35V Likely Oncogenic Loss-of-function 20340136, 19260062 +CDKN2A M53I Oncogenic Loss-of-function 20340136, 19260062 +CDKN2A A148T Inconclusive Inconclusive 15879498, 8603820, 7647780 +CDKN2A R87L Oncogenic Loss-of-function 10491434, 9607312 +CDKN2A A57V Oncogenic Loss-of-function 19260062 +CDKN2A D74Y Likely Oncogenic Loss-of-function 10491434, 19260062 +CDKN2A D108N Likely Oncogenic Likely Loss-of-function 12417717 +CDKN2A A36P Oncogenic Loss-of-function 20340136 +CDKN2A V118D Oncogenic Loss-of-function 7647780 +CDKN2A G93W Likely Oncogenic Loss-of-function 7647780 +CDKN2A I49S Oncogenic Loss-of-function 20340136 +CDKN2A D84G Oncogenic Loss-of-function 10491434 +CDKN2A E88K Oncogenic Loss-of-function 10498896 +CDKN2A A68T Oncogenic Loss-of-function 20340136 +CDKN2A V126D Oncogenic Loss-of-function 20340136 +CDKN2A G35R Likely Oncogenic Loss-of-function 20340136, 19260062 +CDKN2A G67R Oncogenic Loss-of-function 20340136, 19260062 +CDKN2A G23D Oncogenic Loss-of-function 20340136, 19260062 +CDKN2A P114S Oncogenic Loss-of-function 19260062, 8755727 +CDKN2A P48L Oncogenic Loss-of-function 10491434 +CDKN2A R24P Oncogenic Loss-of-function 20340136 +CDKN2B Truncating Mutations Likely Oncogenic Likely Loss-of-function 12032783, 9479825, 11485924 +CDKN2B E35* Oncogenic Loss-of-function 25873077 +CDKN2B D86N Oncogenic Loss-of-function 23715670, 25873077 +CDKN2B Hypermethylation Oncogenic Loss-of-function 19064397, 17489980 +CDKN2B P40T Oncogenic Loss-of-function 25873077 +CDKN2B A23E Oncogenic Loss-of-function 25873077 +CDKN2B Deletion Oncogenic Loss-of-function 12032783, 8078588, 9479825 +CDKN2C Deletion Likely Oncogenic Likely Loss-of-function 18829482, 21994415 +CDKN2C Truncating Mutations Likely Oncogenic Likely Loss-of-function +ASXL1 Deletion Likely Oncogenic Likely Loss-of-function 24255920, 22897849, 24218140 +ASXL1 Truncating Mutations Likely Oncogenic Likely Loss-of-function 19388938, 24216483, 22897849, 21455215, 26095772 +ERBB2 G309A Oncogenic Gain-of-function 23220880, 22908275 +ERBB2 Y1248F Likely Neutral Loss-of-function 1671296 +ERBB2 D808N Likely Oncogenic Likely Gain-of-function 25435280 +ERBB2 Y803N Inconclusive Inconclusive 18413839 +ERBB2 G776S Likely Oncogenic Gain-of-function 18039657 +ERBB2 G292R Likely Oncogenic Likely Gain-of-function 24997986 +ERBB2 Y772_A775dup Oncogenic Gain-of-function 23220880, 16843263, 22908275 +ERBB2 D769A Likely Neutral Loss-of-function 23843458 +ERBB2 T216S Likely Neutral Likely Neutral 22908275, 18772396, 18772890 +ERBB2 G660D Likely Oncogenic Gain-of-function 24317180, 26545934 +ERBB2 N857S Likely Oncogenic Likely Gain-of-function 22046346 +ERBB2 T798M Likely Oncogenic Likely Gain-of-function 22046346 +ERBB2 R896C Oncogenic Gain-of-function 23220880 +ERBB2 Amplification Oncogenic Gain-of-function 23204226, 12124352, 2885917, 24656976, 10716706, 11571643 +ERBB2 C311R Oncogenic Gain-of-function 22908275, 18772890 +ERBB2 G778_P780dup Oncogenic Gain-of-function 23220880 +ERBB2 R143Q Likely Neutral Likely Neutral 24971884 +ERBB2 N319D Likely Neutral Likely Neutral 22908275, 18772396, 18772890, 23389443 +ERBB2 E321G Oncogenic Gain-of-function 22908275, 18772890 +ERBB2 S310Y Oncogenic Gain-of-function 24516025, 24997986, 22908275, 26358791 +ERBB2 M774_A775insAYVM Oncogenic Gain-of-function 17311002 +ERBB2 L726I Likely Oncogenic Gain-of-function 17638894 +ERBB2 Exon 20 insertions/deletions Oncogenic Gain-of-function 16775247, 23220880, 16843263, 23610105, 21353324, 22649146, 22325357, 25899785 +ERBB2 L785F Inconclusive Inconclusive 18413839 +ERBB2 C630Y Inconclusive Inconclusive 18413839 +ERBB2 L726F Likely Oncogenic Likely Gain-of-function 18413839, 25435280 +ERBB2 L869R Likely Oncogenic Likely Gain-of-function 21531810, 26305917, 16397024 Hyman et al. Abstract# PD5-05, AACR 2016 http://cancerres.aacrjournals.org/content/76/4_Supplement/PD5-05 +ERBB2 L755S Oncogenic Gain-of-function 22046346, 18413839, 23220880 +ERBB2 V842I Oncogenic Gain-of-function 24997986, 23220880 +ERBB2 E265K Likely Oncogenic Likely Gain-of-function 24997986 +ERBB2 L915M Inconclusive Inconclusive 18413839 +ERBB2 S653C Oncogenic Gain-of-function 24971884 +ERBB2 D769H Oncogenic Gain-of-function 23220880, 23843458 +ERBB2 V773A Likely Oncogenic Likely Gain-of-function 22046346, 26619011, 16299242 +ERBB2 D769Y Oncogenic Gain-of-function 23220880 +ERBB2 D821N Likely Oncogenic Likely Gain-of-function 18413839 +ERBB2 G309E Oncogenic Gain-of-function 22908275 +ERBB2 V794M Likely Oncogenic Likely Gain-of-function 25435280 +ERBB2 S760A Likely Neutral Likely Neutral 23220880 +ERBB2 E719K Inconclusive Inconclusive 18413839 +ERBB2 L755_T759del Oncogenic Gain-of-function 23220880, 15118073, 15329413, 15118125 +ERBB2 E717K Inconclusive Inconclusive 18413839 +ERBB2 G776delinsLC Oncogenic Gain-of-function 26545934 +ERBB2 C334S Oncogenic Gain-of-function 22908275, 18772890 +ERBB2 Exon 20 insertions Oncogenic Gain-of-function 16775247, 23220880, 16843263, 23610105, 21353324, 22649146, 22325357, 25899785 +ERBB2 K753A Likely Neutral Loss-of-function 22393464, 23680147 +ERBB2 V750E Likely Neutral Likely Neutral 22908275, 18772396, 18772890, 23389443 +ERBB2 L49H Likely Neutral Likely Neutral 22908275, 18772396, 18772890, 23389443 +ERBB2 S783P Inconclusive Inconclusive 18413839 +ERBB2 H878Y Likely Oncogenic Gain-of-function 22046346, 25853726 +ERBB2 D277H Likely Oncogenic Likely Gain-of-function 24971884 +ERBB2 K753E Inconclusive Inconclusive 27697991 +ERBB2 S310F Oncogenic Gain-of-function 24516025, 24997986, 22908275, 26358791 +ERBB2 S335C Likely Oncogenic Likely Gain-of-function 23630663 +ERBB2 V777M Likely Neutral Likely Neutral 18039657, 25720673 +ERBB2 A775_G776insYVMA Oncogenic Gain-of-function 17311002 +ERBB2 V777L Oncogenic Gain-of-function 24516025, 22046346, 23220880 +ERBB2 V777A Likely Oncogenic Likely Gain-of-function 26619011, 22908275, 18772396, 18772890, 23389443 +ERBB2 Y835F Likely Neutral Likely Loss-of-function 23220880 +ERBB2 I767M Oncogenic Gain-of-function 25994018, 23220880 +ERBB2 D845A Likely Neutral Loss-of-function 22908275 +ERBB2 P780L Likely Oncogenic Likely Gain-of-function 18413839 +ERBB2 S1002R Inconclusive Inconclusive 18413839 +ERBB2 L866M Oncogenic Gain-of-function 26243863 +ERBB2 T862A Oncogenic Gain-of-function 22046346 +ERBB2 T733I Likely Oncogenic Likely Gain-of-function 18413839, 16397024 +ERBB2 E719G Inconclusive Inconclusive 18413839 +ERBB2 E812K Inconclusive Inconclusive 18413839 +ERBB2 K753M Likely Neutral Loss-of-function 16489002 +ERBB2 T798I Likely Oncogenic Likely Switch-of-function 18413839, 28274957 +ERBB2 R678Q Likely Oncogenic Likely Gain-of-function 24971884, 23220880 +ERBB2 V839G Inconclusive Inconclusive 18413839 +ERBB2 L755P Oncogenic Gain-of-function 22046346 +ERBB2 G776_V777insYVMA Oncogenic Gain-of-function 16843263 +ERBB2 V659E Oncogenic Gain-of-function 1671296, 7821711 +ERBB2 G776delinsVC Oncogenic Gain-of-function 26545934 +ERBB3 V104M Oncogenic Gain-of-function 23680147 +ERBB3 P262H Oncogenic Gain-of-function 23680147 +ERBB3 A232V Oncogenic Gain-of-function 23680147 +ERBB3 T389K Oncogenic Gain-of-function 23680147 +ERBB3 S846I Oncogenic Gain-of-function 23680147 +ERBB3 Q809R Oncogenic Gain-of-function 23680147 +ERBB3 R669C Inconclusive Inconclusive 23741632 +ERBB3 Amplification Oncogenic Gain-of-function 20418034, 24886126, 25739551 +ERBB3 G284R Oncogenic Gain-of-function 23680147 +ERBB3 V104L Oncogenic Gain-of-function 23680147 +ERBB3 E928G Oncogenic Gain-of-function 23680147 +ERBB3 V714M Likely Neutral Likely Neutral 23680147 +ERBB3 A1131T Inconclusive Inconclusive 23741632 +ERBB4 E542K Oncogenic Gain-of-function 19718025 +ERBB4 G936R Inconclusive Inconclusive 21701703 +ERBB4 K935I Oncogenic Gain-of-function 26050618 +ERBB4 E872K Oncogenic Gain-of-function 19718025 +ERBB4 H618P Likely Neutral Neutral 26050618 +ERBB4 EZR-ERBB4 Fusion Oncogenic Gain-of-function 24727320, 22327623 +ERBB4 M887I Inconclusive Inconclusive 25435280 +ERBB4 T244R Likely Neutral Neutral 26050618 +ERBB4 D595V Oncogenic Gain-of-function 26050618 +ERBB4 E452K Oncogenic Gain-of-function 19718025 +ERBB4 D931Y Likely Oncogenic Gain-of-function 26050618 +ERBB4 Fusions Likely Oncogenic Likely Gain-of-function 24727320 +ERBB4 G785S Inconclusive Inconclusive 25435280 +ERBB4 N181S Likely Neutral Neutral 26050618 +ERBB4 V348L Likely Neutral Neutral 26050618 +ERBB4 R544W Oncogenic Gain-of-function 19718025 +ERBB4 R306S Likely Oncogenic Gain-of-function 26050618 +ERBB4 E317K Oncogenic Gain-of-function 19718025 +ERBB4 E836K Oncogenic Gain-of-function 19718025 +ERBB4 Y285C Oncogenic Gain-of-function 26050618 +ERBB4 E563K Oncogenic Gain-of-function 19718025 +ERBB4 R838Q Inconclusive Inconclusive 25435280 +ERCC2 D513Y Likely Oncogenic Likely Loss-of-function 27504877 +ERCC2 D423N Likely Oncogenic Likely Loss-of-function 27504877 +ERCC2 R631C Likely Oncogenic Likely Loss-of-function 27504877 +ERCC2 N238S Likely Oncogenic Likely Loss-of-function 25096233 +ERCC2 R487W Likely Oncogenic Likely Loss-of-function 27504877 +ERCC2 L461V Likely Oncogenic Likely Loss-of-function 27504877 +ERCC2 D609E Likely Oncogenic Likely Loss-of-function 25096233 +ERCC2 F568fs Likely Oncogenic Likely Loss-of-function 27504877 +ERCC2 G665A Likely Oncogenic Likely Loss-of-function 25096233 +ERCC2 A717G Likely Oncogenic Likely Loss-of-function 27504877 +ERCC2 R592H Likely Neutral Likely Neutral 27504877 +ERCC2 P463L Likely Oncogenic Likely Loss-of-function 25096233 +ERCC2 R450H Likely Neutral Likely Neutral 27504877 +ERCC2 V242F Likely Oncogenic Likely Loss-of-function 25096233 +ERCC2 Y24C Likely Oncogenic Likely Loss-of-function 25096233 +ERCC2 D609G Likely Oncogenic Likely Loss-of-function 25096233 +ERCC2 Amplification Likely Oncogenic Likely Gain-of-function 25096233 +ERCC2 S746fs Likely Oncogenic Likely Loss-of-function 27504877 +ERCC2 Truncating Mutations Likely Oncogenic Likely Loss-of-function +ERCC2 E606G Likely Oncogenic Likely Loss-of-function 25096233 +ERCC2 R601Q Likely Oncogenic Likely Loss-of-function 27504877 +ERCC2 V536M Likely Oncogenic Likely Loss-of-function 27504877 +BRIP1 Truncating Mutations Likely Oncogenic Likely Loss-of-function 16153896, 24040146, 17033622, 21964575, 18628483 +BRIP1 M299I Inconclusive Inconclusive 17145708, 11301010, 14983014 +BRIP1 R173C Oncogenic Loss-of-function 12569564 +BRIP1 R798* Likely Oncogenic Likely Loss-of-function 16153896, 17033622 +BRIP1 K52R Oncogenic Loss-of-function 11301010, 2846277, 8196650, 14983014 +BRIP1 A349P Likely Oncogenic Likely Loss-of-function 20639400, 16116424 +BRIP1 P47A Oncogenic Loss-of-function 11301010, 14983014 +BRIP1 Deletion Likely Oncogenic Likely Loss-of-function 24040146, 21964575, 18628483 +ERCC3 R109* Likely Oncogenic Loss-of-function 27655433 +ERCC3 Truncating Mutations Likely Oncogenic Likely Loss-of-function 16143348, 19942596, 27655433, 8196650 +ERCC4 S786F Oncogenic Loss-of-function 24027083 +ERCC4 Deletion Likely Oncogenic Likely Loss-of-function 9580660, 26074087, 23623386 +ERCC4 E875G Oncogenic Loss-of-function 10499592 +ERCC4 L230P Oncogenic Loss-of-function 23623386 +ERCC4 Truncating Mutations Likely Oncogenic Likely Loss-of-function 9580660, 8887684 +ERCC4 R689S Oncogenic Loss-of-function 24027083, 23623386 +ABL1 M351T Likely Oncogenic Likely Gain-of-function 16046538, 21562040 +ABL1 Y253H Likely Oncogenic Likely Gain-of-function 16482207 +ABL1 E355A Likely Oncogenic Likely Gain-of-function 24456693 +ABL1 Fusions Likely Oncogenic Likely Gain-of-function 21435002 +ABL1 Y253F Oncogenic Gain-of-function 16880519 +ABL1 E459K Likely Oncogenic Likely Gain-of-function 19201023 +ABL1 V299L Likely Oncogenic Likely Gain-of-function 23086624, 18242697 +ABL1 F311L Likely Oncogenic Likely Gain-of-function 21562040 +ABL1 H396P Likely Oncogenic Likely Gain-of-function 21562040, 16424036 +ABL1 L248V Likely Oncogenic Likely Gain-of-function 21562040 +ABL1 F359C Likely Oncogenic Likely Gain-of-function 19798095 +ABL1 L384M Likely Oncogenic Likely Gain-of-function 21562040 +ABL1 L387M Likely Oncogenic Likely Gain-of-function 21562040 +ABL1 D276G Oncogenic Gain-of-function 15510211 +ABL1 E255V Likely Oncogenic Likely Gain-of-function 21562040 +ABL1 F317L Likely Oncogenic Likely Gain-of-function 21562040 +ABL1 E355G Likely Oncogenic Likely Gain-of-function 21562040 +ABL1 F359V Likely Oncogenic Likely Gain-of-function 21562040 +ABL1 T315I Likely Oncogenic Likely Gain-of-function 18794843, 11423618 +ABL1 V379I Likely Oncogenic Likely Gain-of-function 21562040 +ABL1 E279K Likely Oncogenic Likely Gain-of-function 21562040 +ABL1 Q252H Likely Oncogenic Likely Gain-of-function 16046538, 21562040 +ABL1 V289F Likely Oncogenic Likely Gain-of-function 23355941 +ABL1 G250E Likely Oncogenic Likely Gain-of-function 21562040 +ABL1 BCR-ABL1 Fusion Oncogenic Gain-of-function 11345193, 18851712 +ABL1 E281K Likely Oncogenic Likely Gain-of-function 21193419 +ABL1 E255K Likely Oncogenic Likely Gain-of-function 15194504 +ABL1 H396R Likely Oncogenic Likely Gain-of-function 21562040 +ABL1 M244V Likely Oncogenic Likely Gain-of-function 21562040 +CEBPA Truncating Mutations Likely Oncogenic Likely Loss-of-function 11830484, 19322763, 19651529, 18768433, 19075268 +ERF Truncating Mutations Likely Oncogenic Likely Loss-of-function 21548782, 17699159, 17525531, 22198386 +ERG Fusions Likely Oncogenic Likely Gain-of-function 19649210, 23625457, 20585344 +ERG TMPRSS2-ERG Fusion Oncogenic Gain-of-function 22142399, 19396167, 18283340, 17043636 +ERG FUS-ERG Fusion Oncogenic Gain-of-function 8187069, 7970732, 9653171, 25453903 +ERG EWSR1-ERG Fusion Oncogenic Gain-of-function 16357154, 8162068, 25453903 +HLA-A Truncating Mutations Likely Oncogenic Likely Loss-of-function 15546342 +HLA-A 596_619splice Likely Oncogenic Likely Loss-of-function 16216676 +HLA-B Truncating Mutations Likely Oncogenic Likely Loss-of-function 26889905, 19845903, 27807939, 14675390, 28205408 +PDGFRA D1071N Likely Neutral Neutral 23752188 +PDGFRA H845Y Likely Oncogenic Gain-of-function 24132921 +PDGFRA Fusions Likely Oncogenic Likely Gain-of-function 20889717 +PDGFRA V658A Likely Oncogenic Gain-of-function 24132921 +PDGFRA N659K Likely Oncogenic Gain-of-function 15928335 +PDGFRA C456_N468del Oncogenic Gain-of-function 23970477 +PDGFRA C456_R481del Oncogenic Gain-of-function 23970477 +PDGFRA V561_I562insER Oncogenic Gain-of-function 15928335, 12522257 +PDGFRA N870S Likely Neutral Neutral 23752188 +PDGFRA H570R Likely Neutral Neutral 21224473 +PDGFRA BCR-PDGFRA Fusion Likely Oncogenic Gain-of-function 12023981, 12944919, 15034867 +PDGFRA I843del Likely Oncogenic Gain-of-function 22745105 +PDGFRA I834V Likely Neutral Neutral 24132921 +PDGFRA KDR-PDGFRA Fusion Oncogenic Gain-of-function 20889717, 16690743 +PDGFRA FIP1L1-PDGFRA Fusion Oncogenic Gain-of-function 16754777, 19187542, 16645167, 24057647, 12660384, 16690743, 24407160, 16608506, 21224473, 19212337, 12781364, 27021554, 16030188 +PDGFRA W349C Likely Neutral Likely Loss-of-function 23752188 +PDGFRA T674I Likely Oncogenic Likely Gain-of-function 22745105 +PDGFRA E996K Likely Neutral Neutral 23752188 +PDGFRA P577S Likely Oncogenic Gain-of-function 24132921 +PDGFRA Y555C Likely Oncogenic Gain-of-function 25975287, 17087943 +PDGFRA CDK5RAP2-PDGFRA Fusion Oncogenic Gain-of-function 16845659 +PDGFRA V544_L545insAVLVLLVIVIISLI Oncogenic Gain-of-function 23970477 +PDGFRA A633T Likely Oncogenic Likely Gain-of-function 24132921 +PDGFRA E311_K312del Oncogenic Gain-of-function 23970477 +PDGFRA P130S Likely Neutral Likely Neutral 23752188 +PDGFRA I562M Likely Neutral Neutral 21224473 +PDGFRA H845_N848delinsP Oncogenic Gain-of-function 15928335, 12522257, 22745105 +PDGFRA H650Q Oncogenic Gain-of-function 21224473 +PDGFRA S478P Likely Neutral Likely Neutral 22733151, 12949711, 19366796 +PDGFRA N659R Likely Oncogenic Gain-of-function 15928335 +PDGFRA V561D Oncogenic Gain-of-function 17087936, 12949711, 15928335, 19217431, 12522257, 18955458, 22665524, 22745105 +PDGFRA C450_K451insMIEWMI Oncogenic Gain-of-function 23970477 +PDGFRA V561A Oncogenic Likely Gain-of-function 24132921 +PDGFRA N659S Likely Oncogenic Gain-of-function 21224473 +PDGFRA ETV6-PDGFRA Fusion Oncogenic Gain-of-function 17555450 +PDGFRA KIF5B-PDGFRA Fusion Oncogenic Gain-of-function 17555450, 16498388 +PDGFRA Q579R Likely Oncogenic Gain-of-function 24132921 +PDGFRA D842_H845del Likely Oncogenic Gain-of-function 22745105 +PDGFRA V536E Oncogenic Gain-of-function 23752188 +PDGFRA D842Y Likely Oncogenic Gain-of-function 15928335, 24132921, 22745105 +PDGFRA F808L Likely Neutral Loss-of-function 23752188 +PDGFRA D842_I843delinsIM Oncogenic Gain-of-function 15928335, 22745105 +PDGFRA S566_E571delinsR Likely Oncogenic Gain-of-function 15928335, 12522257 +PDGFRA A633V Likely Neutral Neutral 24132921 +PDGFRA R481G Likely Neutral Likely Neutral 21224473 +PDGFRA 560_561insER Oncogenic Gain-of-function 22745105 +PDGFRA D842I Likely Oncogenic Gain-of-function 15928335, 22745105 +PDGFRA Y375_K455del Oncogenic Gain-of-function 20889717, 12569364 +PDGFRA Y849S Likely Oncogenic Gain-of-function 21224473 +PDGFRA G829R Likely Neutral Neutral 23752188 +PDGFRA Y849C Likely Oncogenic Gain-of-function 15146165, 15928335 +PDGFRA R841K Oncogenic Gain-of-function 24132921 +PDGFRA L507P Likely Neutral Likely Neutral 24057647, 21224473 +PDGFRA D846Y Likely Oncogenic Gain-of-function 15928335, 22745105 +PDGFRA Amplification Oncogenic Gain-of-function 21931021, 20685895, 18772890, 22745105, 16357008 +PDGFRA W559_R560del Oncogenic Gain-of-function 26396737 +PDGFRA S584L Likely Oncogenic Gain-of-function 24132921 +PDGFRA D842V Oncogenic Gain-of-function 24132921, 22665524, 23752188, 18794084, 17087936, 12949711, 15928335, 23970477, 19217431, 12522257, 18955458, 22745105, 15685537, 16030188 +PDGFRA D568N Likely Oncogenic Gain-of-function 24132921 +PDGFRA K830R Likely Neutral Neutral 24132921 +PDGFRA N848K Likely Oncogenic Gain-of-function 15928335 +PDGFRA I843_D846del Likely Oncogenic Gain-of-function 18955458, 22745105 +PDGFRA R748G Oncogenic Gain-of-function 21224473 +PDGFRA STRN-PDGFRA Fusion Oncogenic Gain-of-function 17555450 +PDGFRA G853D Oncogenic Gain-of-function 24132921 +PDGFRA D842_M844del Likely Oncogenic Gain-of-function 18794084 +PDGFRA V469A Likely Oncogenic Likely Gain-of-function 23752188 +PDGFRB GIT2-PDGFRB Fusion Likely Oncogenic Likely Gain-of-function 17296564, 18262053 +PDGFRB KIAA1509-PDGFRB Fusion Likely Oncogenic Likely Gain-of-function 12907457 +PDGFRB SPTBN1-PDGFRB Fusion Likely Oncogenic Likely Gain-of-function 18262053 +PDGFRB NIN-PDGFRB Fusion Likely Oncogenic Likely Gain-of-function 15087377 +PDGFRB R561C Inconclusive Inconclusive 23731537 +PDGFRB HIP1-PDGFRB Fusion Oncogenic Gain-of-function 9616134 +PDGFRB RABEP1-PDGFRB Fusion Oncogenic Gain-of-function 11588050 +PDGFRB Amplification Inconclusive Inconclusive 18515258, 18157090, 18612157, 16630177, 21729646, 18670317 +PDGFRB ATF7IP-PDGFRB Fusion Likely Oncogenic Likely Gain-of-function 8168137 +PDGFRB TP53BP1-PDGFRB Fusion Likely Oncogenic Likely Gain-of-function 15492236 +PDGFRB PRKG2-PDGFRB Fusion Likely Oncogenic Likely Gain-of-function 17296564, 18262053 +PDGFRB L658P Likely Neutral Loss-of-function 23255827, 26599395 +PDGFRB E1071W Likely Neutral Likely Loss-of-function 23255827, 26599395 +PDGFRB P660T Inconclusive Inconclusive 23731542 +PDGFRB PDE4DIP-PDGFRB Fusion Likely Oncogenic Likely Gain-of-function 12907457 +PDGFRB ETV6-PDGFRB Fusion Oncogenic Gain-of-function 22271894, 8168137, 19644140, 19100521 +PDGFRB KANK1-PDGFRB Fusion Oncogenic Gain-of-function 21685469 +PDGFRB GOLGA4-PDGFRB Fusion Likely Oncogenic Likely Gain-of-function 20085582 +PDGFRB R987W Likely Neutral Likely Loss-of-function 23255827, 26599395 +PDGFRB WDR48-PDGFRB Fusion Likely Oncogenic Likely Gain-of-function 20085582 +PDGFRB Fusions Likely Oncogenic Likely Gain-of-function 20581310, 8962143, 19806146, 22271894, 8168137, 22897847, 18483217 +PDGFRB EBF1-PDGFRB Fusion Oncogenic Gain-of-function 24186319, 8168137, 22897847, 23835704 +PDGFRB GPIAP1-PDGFRB Fusion Likely Oncogenic Likely Gain-of-function 17296564 +PDGFRB V665A Oncogenic Loss-of-function 26279204 +PDGFRB BIN2-PDGFRB Fusion Likely Oncogenic Likely Gain-of-function 20085582 +PDGFRB CEP85L-PDGFRB Fusion Oncogenic Likely Gain-of-function 23186533, 15492236 +RBM10 Deletion Likely Oncogenic Likely Loss-of-function 26853560, 24000153, 24332178 +RBM10 V354E Oncogenic Loss-of-function 20007775, 24332178 +RBM10 Truncating Mutations Likely Oncogenic Likely Loss-of-function 21910224, 24000153, 22980975, 25079552, 24332178 +KDM5C M1_E165DEL Likely Oncogenic Loss-of-function 25666439 +KDM5C P480L Likely Oncogenic Loss-of-function 25666439 +KDM5C D402Y Likely Oncogenic Loss-of-function 25666439 +KDM5C Overexpression Likely Oncogenic Likely Gain-of-function 25016185 +KDM5C Truncating Mutations Likely Oncogenic Likely Loss-of-function +KDM5C V1075Yfs*2 Likely Oncogenic Loss-of-function 25666439 +ESR1 V534E Likely Neutral Neutral 27986707 +ESR1 Y537N Likely Oncogenic Gain-of-function 24185512, 24398047, 24185510, 9102207, 11322512, 9500442 +ESR1 L536P Likely Oncogenic Gain-of-function 10787412, 9234721, 1630819, 9774463, 15282324 +ESR1 A546D Oncogenic Gain-of-function 27986707 +ESR1 Y537S Oncogenic Gain-of-function 24185512, 24185510, 26836308, 27986707, 8923465, 9398213, 11914066 +ESR1 ESR1-CCDC170 Fusion Oncogenic Gain-of-function 25099679, 22496636, 22101766 +ESR1 V422del Likely Oncogenic Gain-of-function 27986707 +ESR1 ESR1-YAP1 Fusion Oncogenic Gain-of-function 24055055 +ESR1 S432L Likely Neutral Neutral 27986707 +ESR1 D538G Oncogenic Gain-of-function 24185512, 24398047, 24185510, 24217577, 1630819, 26836308, 15282324 +ESR1 L536R Likely Oncogenic Gain-of-function 24185512, 1630819, 15282324 +ESR1 E380Q Likely Oncogenic Gain-of-function 9259327, 1630819, 8114756, 15282324 +ESR1 S463P Likely Oncogenic Likely Gain-of-function 24185512, 1630819, 15282324 +ESR1 L536Q Likely Oncogenic Gain-of-function 24185510, 1630819, 15282324 +ESR1 L536H Likely Oncogenic Gain-of-function 1630819, 15282324, 15159406 +ESR1 Y537C Likely Oncogenic Gain-of-function 24398047, 24185510, 1630819, 11322512, 9500442, 15282324 +ESR1 L469V Likely Oncogenic Gain-of-function 1630819, 27986707, 15282324 +ESR1 Fusions Likely Oncogenic Likely Gain-of-function 25099679, 24055055 +ETV1 EWSR1-ETV1 Fusion Oncogenic Gain-of-function 16357154, 7700648, 25453903 +ETV1 Amplification Oncogenic Gain-of-function 23908683, 20160028 +ETV1 Fusions Likely Oncogenic Likely Gain-of-function 23814484, 21298110, 18794142, 23625457, 17671502 +ETV1 TMPRSS2-ETV1 Fusion Oncogenic Gain-of-function 18563191, 23512661 +ETV6 R369W Likely Oncogenic Likely Loss-of-function 25581430, 26522332, 27365488 +ETV6 R418G Likely Oncogenic Loss-of-function 25807284 +ETV6 ETV6-NTRK3 Fusion Oncogenic Gain-of-function 21804605, 18068631, 21148487 +ETV6 385_418del Likely Oncogenic Loss-of-function 25807284 +ETV6 R369Q Likely Oncogenic Likely Loss-of-function 25581430, 26522332, 26102509, 27365488 +ETV6 ETV6-FLT3 Fusion Oncogenic Gain-of-function 16761019 +ETV6 P214L Likely Oncogenic Loss-of-function 25807284 +ETV6 Fusions Likely Oncogenic Likely Gain-of-function 12173038, 10702799, 22578774 +TSC1 Truncating Mutations Likely Oncogenic Likely Loss-of-function 23485365, 24529379, 20301399 +TSC1 F216A Likely Oncogenic Likely Loss-of-function 18397877 +TSC1 H68R Likely Oncogenic Likely Loss-of-function 18397877 +TSC1 L180P Likely Oncogenic Loss-of-function 18830229 +TSC1 R1097H Likely Neutral Neutral 18830229 +TSC1 V128del Likely Oncogenic Loss-of-function 18830229 +TSC1 L191H Likely Oncogenic Loss-of-function 18830229 +TSC1 G305W Likely Neutral Neutral 18830229 +TSC1 M224R Oncogenic Loss-of-function 18830229 +TSC1 H105R Likely Oncogenic Loss-of-function 18397877 +TSC1 N198_F199delinsI Likely Oncogenic Loss-of-function 18830229, 11781698, 17304050 +TSC1 R509Q Likely Neutral Neutral 18830229 +TSC1 T417I Likely Neutral Neutral 18397877, 10570911, 10607950 +TSC1 V220F Likely Oncogenic Likely Loss-of-function 22923433 +TSC1 H206D Likely Oncogenic Loss-of-function 18397877 +TSC1 S35Q Likely Oncogenic Loss-of-function 18397877 +TSC1 F158C Likely Oncogenic Loss-of-function 18397877 +TSC1 R246K Likely Neutral Neutral 18830229 +TSC1 Deletion Likely Oncogenic Likely Loss-of-function 23485365, 24529379, 11741833, 10353610 +TSC1 K82T Likely Neutral Likely Neutral 23857276, 21309039 +TSC1 L117P Likely Oncogenic Loss-of-function 18830229 +TSC1 G305R Likely Neutral Neutral 18830229 +TSC1 G1035S Likely Neutral Neutral 18830229 +IKZF1 Deletion Likely Oncogenic Loss-of-function 27067989, 19129520, 27815723, 26202931 +TSC2 Truncating Mutations Likely Oncogenic Likely Loss-of-function 24529379, 14729330, 25724664, 14561707 +TSC2 V241del Oncogenic Loss-of-function 22903760 +TSC2 R505Q Likely Oncogenic Likely Loss-of-function 22903760 +TSC2 L493V Likely Oncogenic Likely Loss-of-function 22903760 +TSC2 E1552del Oncogenic Loss-of-function 22903760 +TSC2 V1673D Likely Oncogenic Likely Loss-of-function 22903760 +TSC2 F615S Likely Oncogenic Likely Loss-of-function 15483652, 11741832 +TSC2 G1596V Likely Oncogenic Likely Loss-of-function 22903760 +TSC2 V705M Likely Oncogenic Loss-of-function 22903760 +TSC2 R905G Likely Oncogenic Loss-of-function 17120248 +TSC2 Y598C Likely Oncogenic Likely Loss-of-function 22903760 +TSC2 L410R Oncogenic Loss-of-function 22903760 +TSC2 A889P Oncogenic Loss-of-function 22903760 +TSC2 H1620R Oncogenic Loss-of-function 22903760 +TSC2 L493P Likely Oncogenic Gain-of-function 22903760 +TSC2 S1498N Likely Oncogenic Likely Loss-of-function 15972957 +TSC2 L448P Likely Oncogenic Likely Loss-of-function 22903760 +TSC2 V299G Likely Oncogenic Likely Loss-of-function 22903760 +TSC2 T1623I Oncogenic Loss-of-function 22903760 +TSC2 V1673F Likely Oncogenic Likely Loss-of-function 22903760 +TSC2 H597Y Oncogenic Loss-of-function 22903760 +TSC2 R462C Likely Oncogenic Likely Loss-of-function 22903760 +TSC2 L1584R Likely Oncogenic Likely Loss-of-function 22903760 +TSC2 R905Q Likely Oncogenic Loss-of-function 17120248 +TSC2 E75G Likely Oncogenic Likely Loss-of-function 22903760, 27493206 +TSC2 A328P Likely Oncogenic Likely Loss-of-function 22903760 +TSC2 Deletion Oncogenic Likely Loss-of-function 11281455, 25724664, 26540169, 25281918, 14561707 +TSC2 C696Y Likely Oncogenic Loss-of-function 15483652, 11741832 +TSC2 Q1554H Likely Oncogenic Likely Loss-of-function 22903760 +TSC2 T1203K Oncogenic Loss-of-function 22903760 +TSC2 S1653P Oncogenic Loss-of-function 22903760 +TSC2 W1610G Likely Oncogenic Likely Loss-of-function 22903760 +TSC2 V769E Likely Oncogenic Loss-of-function 15483652, 11741832 +TSC2 S1653F Oncogenic Loss-of-function 22903760 +TSC2 V705E Oncogenic Loss-of-function 22903760 +TSC2 R1200W Likely Oncogenic Loss-of-function 21332470 +TSC2 L830R Oncogenic Loss-of-function 22903760 +TSC2 L826P Likely Oncogenic Likely Loss-of-function 15483652, 22903760 +TSC2 G1567D Likely Oncogenic Likely Loss-of-function 22903760 +TSC2 Y1571N Oncogenic Loss-of-function 22903760 +TSC2 L792R Oncogenic Loss-of-function 22903760 +TSC2 P1675L Likely Oncogenic Loss-of-function 11290735, 22903760, 12205112 +TSC2 R905W Likely Oncogenic Loss-of-function 17120248 +TSC2 S1036P Likely Oncogenic Likely Loss-of-function 21332470 +TSC2 P1709L Likely Oncogenic Likely Loss-of-function 22903760 +TSC2 L146R Likely Oncogenic Likely Loss-of-function 22903760 +TSC2 I427M Likely Oncogenic Likely Loss-of-function 22903760 +TSC2 R611Q Likely Oncogenic Loss-of-function 15483652, 11741832 +TSC2 A614D Likely Oncogenic Loss-of-function 15483652, 11741832 +TSC2 R611W Likely Oncogenic Loss-of-function 15483652, 11741832 +TSC2 Q1503P Likely Oncogenic Likely Loss-of-function 22903760 +TSC2 L844R Likely Oncogenic Likely Loss-of-function 22903760 +EWSR1 EWSR1-ATF1 Fusion Likely Oncogenic Likely Gain-of-function 24320889, 21822206, 25364450, 19801966 +EWSR1 EWSR1-CREB1 Fusion Likely Oncogenic Likely Gain-of-function 24320889, 21822206, 25364450, 19801966 +EWSR1 EWSR1-WT1 Fusion Oncogenic Gain-of-function 9591781, 11278460, 10999739, 11237525, 24321497 +EWSR1 EWSR1-ETV4 Fusion Likely Oncogenic Likely Gain-of-function 8605035 +EWSR1 EWSR1-ETV1 Fusion Oncogenic Gain-of-function 25109552 +EWSR1 EWSR1-FEV Fusion Likely Oncogenic Likely Gain-of-function 9121764 +EWSR1 EWSR1-DDIT3 Fusion Oncogenic Gain-of-function 24320889, 7805034, 24790523 +EWSR1 EWSR1-ERG Fusion Oncogenic Gain-of-function 18500345, 8162068, 10749119 +EWSR1 EWSR1-YY1 Fusion Oncogenic Gain-of-function 23630070 +EWSR1 EWSR1-NR4A3 Fusion Oncogenic Gain-of-function 22592656, 16604165 +EWSR1 Fusions Likely Oncogenic Likely Gain-of-function 8605035, 23329308, 21113140, 8834175 NCCN Bone Cancer. Volume# v.2017 https://www.nccn.org/professionals/physician_gls/pdf/bone.pdf +EWSR1 EWSR1-FLI1 Fusion Oncogenic Gain-of-function 17250957, 22930730, 24320889, 11715049, 25453903, 12432241 +ACVR1 R206H Likely Oncogenic Gain-of-function 24705254, 20463014, 22977237, 24769718 +ACVR1 G328E Likely Oncogenic Likely Gain-of-function 24705254, 20463014, 22977237, 24769718 +ACVR1 G328V Likely Oncogenic Gain-of-function 24705254, 20463014, 24705250, 24769718 +ACVR1 Q207E Likely Oncogenic Likely Gain-of-function 24852373 +FOXA1 L455M Likely Oncogenic Likely Loss-of-function 22722839 +FOXA1 Amplification Oncogenic Gain-of-function 22138582, 19470727, 22722839, 21147910, 22960745, 23622249, 19372580, 2298097, 23539448, 25079552, 12234996 +FOXA1 M253K Likely Oncogenic Likely Loss-of-function 23539448 +FOXA1 F400I Likely Oncogenic Likely Loss-of-function 22722839, 23539448 +FOXA1 G87R Likely Oncogenic Likely Loss-of-function 22722839 +FOXA1 S453fs* Likely Oncogenic Likely Gain-of-function 22722839 +FOXA1 L388M Likely Oncogenic Likely Loss-of-function 22722839 +FOXA1 Deletion Likely Oncogenic Likely Loss-of-function 24840332 +MDM2 Amplification Oncogenic Gain-of-function 9671804, 24667108, 15199139, 27194168 +ARID1A Truncating Mutations Likely Oncogenic Likely Loss-of-function 21900401, 24899687, 25625625 +ARID1A Deletion Likely Oncogenic Loss-of-function 22249247, 23097632, 21412130, 23208470 +EZH2 Amplification Oncogenic Gain-of-function 16330673, 12374981, 14500907, 21837672 +EZH2 A677G Likely Oncogenic Switch-of-function 22323599 +EZH2 Y646C Oncogenic Switch-of-function 21078963, 21190999 +EZH2 Y646N Oncogenic Switch-of-function 21078963, 21190999, 24469040, 21810159, 21843048 +EZH2 Y646F Oncogenic Switch-of-function 21078963, 21190999, 27135738, 24469040, 21810159, 21843048 +EZH2 Overexpression Oncogenic Gain-of-function 16330673, 12374981, 14500907, 21837672 +EZH2 Y646H Oncogenic Switch-of-function 21078963, 21190999 +EZH2 Y646S Oncogenic Switch-of-function 21078963, 21190999 +MDM4 G57A Oncogenic Loss-of-function 15199139, 9131587 +MDM4 Amplification Oncogenic Gain-of-function 9523192, 15199139, 7585611 +KLF4 K409Q Likely Oncogenic Likely Gain-of-function 23404370 +RXRA S247Y Inconclusive Inconclusive 24476821 +RXRA S247F Inconclusive Inconclusive 24476821 +MAP3K1 Truncating Mutations Likely Oncogenic Inconclusive 24003131, 24386504 +MAP3K1 E1286V Likely Neutral Likely Neutral 25899310 +MAP3K1 T779fs Likely Oncogenic Likely Loss-of-function 25899310 +MAP3K1 T1481fs Likely Oncogenic Likely Loss-of-function 25899310 +AXIN1 Truncating Mutations Likely Oncogenic Likely Loss-of-function 10700176, 25236910 +AXIN2 Truncating Mutations Likely Oncogenic Likely Loss-of-function 15802015, 17373666 +BAP1 Deletion Likely Oncogenic Likely Loss-of-function 21874000, 26246155, 24633195, 25970771 +BAP1 F81V Likely Oncogenic Loss-of-function 26680512 +BAP1 I47F Likely Oncogenic Loss-of-function 26680512 +BAP1 Truncating Mutations Likely Oncogenic Likely Loss-of-function 21874000, 18757409 +BAP1 E685V Likely Oncogenic Loss-of-function 25830670 +BAP1 C91S Oncogenic Loss-of-function 19815555, 9528852 +BAP1 C91A Likely Oncogenic Loss-of-function 18757409 +BAP1 F170I Likely Oncogenic Loss-of-function 26081045 +BAP1 A95D Likely Oncogenic Loss-of-function 26680512, 24894717, 18757409 +BAP1 G178V Likely Oncogenic Loss-of-function 24894717, 18757409 +MEN1 Truncating Mutations Likely Oncogenic Likely Loss-of-function +MEN1 Deletion Oncogenic Loss-of-function 12746426, 27076911, 9510467, 16740708, 21627674, 14633735, 12941803 +FANCA Deletion Likely Oncogenic Likely Loss-of-function 15522956, 12637330, 24689079, 8374893, 12827451, 14749703 +FANCA L274P Likely Oncogenic Loss-of-function 16720839 +FANCA S858R Likely Oncogenic Loss-of-function 12955722 +FANCA R1055L Likely Oncogenic Likely Loss-of-function 16720839 +FANCA L210R Likely Oncogenic Loss-of-function 16720839 +FANCA Truncating Mutations Likely Oncogenic Likely Loss-of-function 21273304, 15522956, 24689079, 12827451 +FANCA H492R Likely Oncogenic Loss-of-function 16720839, 12444097 +FANCA S1088F Likely Oncogenic Likely Loss-of-function Wilkes et al. Molecular Case Studies, 2016 http://molecularcasestudies.cshlp.org/content/early/2017/05/03/mcs.a001487.short +FANCA Y510C Likely Oncogenic Loss-of-function 16720839 +FANCA W183A Likely Oncogenic Loss-of-function 10468606, 11050007, 11161829 +FANCC Truncating Mutations Likely Oncogenic Likely Loss-of-function 11520787, 16687415, 20509860 +MET Y1230C Likely Oncogenic Gain-of-function 9826708, 18709663 +MET H1094R Oncogenic Gain-of-function 9563489 +MET D1010H Likely Oncogenic Likely Gain-of-function 27666659, 14559814, 16227611, 25898965, 25971938, 15735036, 27343443, 16397241, 26892698, 19096300 +MET X1009_splice Oncogenic Gain-of-function 15735036, 16397241, 19096300 +MET H1094Y Oncogenic Gain-of-function 15064724, 24061647 +MET E168D Likely Oncogenic Gain-of-function 19318576 Ma et al. Abstract# 14010 ASCO 2010 http://hwmaint.meeting.ascopubs.org/cgi/content/abstract/25/18_suppl/14010 +MET X1006_splice Oncogenic Gain-of-function 15735036, 16397241, 19096300 +MET L1195V Oncogenic Gain-of-function 15064724, 24061647 +MET T992I Likely Oncogenic Gain-of-function 25605252, 14559814, 21970370, 11042681, 22973954, 15735036, 17322284 +MET N1100Y Oncogenic Gain-of-function 12460923 +MET V1220I Likely Oncogenic Gain-of-function 19783361 +MET Y1003F Oncogenic Gain-of-function 16227611, 15123609, 11741535 +MET H1106D Likely Oncogenic Likely Gain-of-function 10327054 +MET X1008_splice Oncogenic Gain-of-function 15735036, 16397241, 19096300 +MET M1250T Oncogenic Gain-of-function 10327054, 10871851, 9826715, 15557554 +MET Y1003C Likely Oncogenic Likely Gain-of-function 16227611, 15123609, 11741535 +MET Y1230H Oncogenic Gain-of-function 27666659, 9826708, 9326629 +MET V1188L Oncogenic Gain-of-function 15064724, 24061647 +MET PTPRZ1-MET Fusion Likely Oncogenic Likely Gain-of-function 25135958 +MET F1200I Oncogenic Gain-of-function 24173966, 21697284 +MET Amplification Oncogenic Gain-of-function 16461907, 20129249, 19117057, 17667909, 22869872, 18077425, 17463250 +MET D1010Y Likely Oncogenic Likely Gain-of-function 27666659, 14559814, 16227611, 25898965, 25971938, 15735036, 27343443, 16397241, 19096300 +MET X963_splice Oncogenic Gain-of-function 15735036, 16397241, 19096300 +MET R970C Inconclusive Inconclusive 20670955, 14559814, 22973954 +MET Y1235D Oncogenic Gain-of-function 12460923, 10734314 +MET H1094L Oncogenic Gain-of-function 19783361, 24061647 +MET 963_D1010splice Oncogenic Gain-of-function 15735036, 16397241, 19096300 +MET D1010N Likely Oncogenic Likely Gain-of-function 26892698 +MET Overexpression Oncogenic Gain-of-function 9554529, 9870683, 8077049, 11381087, 15375530, 10698493 +MET V1070E Oncogenic Gain-of-function 25401301 +MET V1092I Oncogenic Gain-of-function 24061647, 10417759 +MET X1007_splice Oncogenic Gain-of-function 15735036, 16397241, 19096300 +MET D1228N Likely Oncogenic Likely Gain-of-function 9826708, 27343442 +MET N375S Inconclusive Inconclusive 16171945, 19723643 +MET Y1003* Likely Oncogenic Likely Gain-of-function 25079552, 16397241 +MET 981_1028splice Oncogenic Gain-of-function 15735036, 16397241, 19096300 +U2AF1 Q157R Oncogenic Switch-of-function 25267526, 25311244 +U2AF1 Q157P Likely Oncogenic Switch-of-function 25267526, 25311244 +U2AF1 S34Y Oncogenic Switch-of-function 22158538, 25267526, 25311244 +U2AF1 S34F Likely Oncogenic Switch-of-function 25965570, 22158538, 25267526, 25311244 +KMT2C Deletion Likely Oncogenic Likely Loss-of-function 23166019, 11891048, 24081332, 24794707, 9834205 +KMT2C Truncating Mutations Likely Oncogenic Likely Loss-of-function 23259788, 19433796, 25537518 +KMT2C A1685S Likely Oncogenic Loss-of-function 25998713, 25151357 +KMT2C S3660L Likely Neutral Likely Neutral 24965397 +PARP1 Truncating Mutations Likely Oncogenic Likely Loss-of-function +FAT1 P4309A Likely Oncogenic Likely Loss-of-function 23354438 +FAT1 A4419S Likely Oncogenic Likely Loss-of-function 23354438 +FAT1 T4511I Likely Oncogenic Likely Loss-of-function 23354438 +FAT1 Truncating Mutations Likely Oncogenic Likely Loss-of-function 24718888, 26905694, 23354438 +FAT1 Deletion Oncogenic Loss-of-function 21617878, 23354438 +ARID1B Truncating Mutations Likely Oncogenic Likely Loss-of-function 23660946, 22233809, 26340334 +ARID1B Deletion Likely Oncogenic Likely Loss-of-function 23202128, 25674384, 26340334 +PIK3CA E453K Oncogenic Gain-of-function 20593314, 21266528, 26627007 +PIK3CA N345K Oncogenic Gain-of-function 18074223, 20593314, 22949682, 17376864 +PIK3CA N1044K Oncogenic Gain-of-function 26627007 +PIK3CA M1043I Oncogenic Gain-of-function 22120714, 17376864 +PIK3CA G118D Likely Oncogenic Gain-of-function 22949682 +PIK3CA E81K Likely Oncogenic Likely Gain-of-function 25915946, 21266528 +PIK3CA M1043V Oncogenic Gain-of-function 17376864 +PIK3CA E542G Inconclusive Inconclusive 17990317, 25054828, 22553375, 25401499 +PIK3CA E545Q Oncogenic Gain-of-function 20593314, 26627007 +PIK3CA E453A Likely Oncogenic Likely Gain-of-function 20593314, 21266528 +PIK3CA I31M Likely Neutral Likely Neutral 26627007 +PIK3CA E110K Likely Oncogenic Likely Gain-of-function 23619167 +PIK3CA C420R Oncogenic Gain-of-function 18074223, 21266528, 22949682 +PIK3CA Q546P Oncogenic Gain-of-function 17626883, 17376864 +PIK3CA R38H Oncogenic Gain-of-function 15930273, 20593314, 17376864 +PIK3CA H1047L Oncogenic Gain-of-function 20593314, 26627007, 22120714, 17376864 +PIK3CA A1020V Likely Neutral Likely Neutral 26627007 +PIK3CA E545A Oncogenic Gain-of-function 20593314, 26627007, 17376864 +PIK3CA Q546K Oncogenic Gain-of-function 27126994, 17376864 +PIK3CA E545G Oncogenic Gain-of-function 20593314, 26627007, 17376864 +PIK3CA T1025S Oncogenic Gain-of-function 17376864 +PIK3CA P447_L455del Likely Oncogenic Likely Gain-of-function 27126994 +PIK3CA K111N Likely Oncogenic Likely Gain-of-function 18074223, 21266528, 26627007, 22949682, 17376864 +PIK3CA Q60K Likely Neutral Likely Neutral 18074223 +PIK3CA H701P Likely Neutral Likely Neutral 18074223, 17376864 +PIK3CA G106R Likely Oncogenic Gain-of-function 21266528 +PIK3CA E542K Oncogenic Gain-of-function 20593314, 16432179, 26627007, 17376864 +PIK3CA E365K Likely Oncogenic Gain-of-function 21266528 +PIK3CA C378R Likely Oncogenic Likely Gain-of-function 17363507 +PIK3CA V344G Inconclusive Inconclusive 27007084, 17050665, 24718026 +PIK3CA E542V Oncogenic Gain-of-function 26627007 +PIK3CA E453Q Likely Oncogenic Likely Gain-of-function 15930273, 20593314 +PIK3CA I391M Likely Neutral Likely Neutral 20530683 +PIK3CA Q546E Oncogenic Gain-of-function 26627007 +PIK3CA D350G Likely Oncogenic Gain-of-function 24265155 +PIK3CA V344A Likely Oncogenic Likely Gain-of-function 20593314, 21266528 +PIK3CA H1047Y Oncogenic Gain-of-function 20593314, 26627007, 17376864 +PIK3CA E116K Likely Neutral Likely Neutral 17376864 +PIK3CA H1047R Oncogenic Gain-of-function 16322248, 19029981, 22960745, 16341083, 22214849, 16432179, 26627007, 21822287, 27126994, 25079552, 22120714, 21324922, 23940356, 25631445, 20593314, 22941189, 22370636, 23787421, 23636398, 17376864 +PIK3CA P449_L455del Likely Oncogenic Gain-of-function 20593314, 21266528, 27126994 +PIK3CA D1029Y Likely Oncogenic Likely Gain-of-function 19394761 +PIK3CA R108H Likely Oncogenic Gain-of-function 18829572 +PIK3CA P539R Oncogenic Gain-of-function 17376864 +PIK3CA R93Q Likely Oncogenic Likely Gain-of-function 21266528 +PIK3CA E545K Oncogenic Gain-of-function 16322248, 20593314, 16432179, 26627007, 17376864 +PIK3CA G106_R108del Likely Oncogenic Likely Gain-of-function 19394761 +PIK3CA R93W Likely Oncogenic Gain-of-function 20593314, 21266528, 22949682 +PIK3CA R115L Likely Neutral Likely Neutral 23619167 +PIK3CA G106V Likely Oncogenic Gain-of-function 15930273, 21266528 +PIK3CA P449T Oncogenic Gain-of-function 20530683 +PIK3CA K111E Oncogenic Gain-of-function 18074223, 21266528, 22949682 +PIK3CA N345I Likely Oncogenic Likely Gain-of-function 20593314, 26627007 +PIK3CA G106D Likely Oncogenic Likely Gain-of-function 27555788, 15930273, 21266528 +PIK3CA A1066V Likely Neutral Likely Neutral 27465249, 22430209 +PIK3CA E78K Inconclusive Inconclusive 27126994 +PIK3CA Q546R Oncogenic Gain-of-function 17626883, 26627007 +PIK3CA G914R Likely Oncogenic Likely Gain-of-function 22228622, 22729224 +PIK3CA Amplification Likely Oncogenic Likely Gain-of-function 21720365, 22960745, 17992665, 23136191, 19706770, 22292935, 22994622, 19697359, 25631445, 24608574, 26876212, 23636398, 27095573, 17803655 Zehir A et al. Nature Medicine, 2017 http://doi:10.1038/nm.4333 +PIK3CA N1068fs*4 Likely Oncogenic Gain-of-function 21703185 +PIK3CA E542Q Likely Oncogenic Likely Gain-of-function 16432179, 26627007, 17376864 +PIK3CA E579K Likely Oncogenic Likely Gain-of-function 17376864 +PIK3CA R88Q Likely Oncogenic Gain-of-function 22949682 +PIK3CB R48W Likely Oncogenic Likely Gain-of-function 18755892, 26000489 +PIK3CB D1067V Oncogenic Gain-of-function 25982275 +PIK3CB E1051K Likely Oncogenic Likely Gain-of-function 18755892, 26000489 +PIK3CB E552K Likely Oncogenic Gain-of-function 16339315 +PIK3CB E633K Likely Oncogenic Likely Gain-of-function 23734178, 20668451 +PIK3CB D1067A Likely Oncogenic Gain-of-function 26759240 +PIK3CB ACPP-PIK3CB Fusion Likely Oncogenic Likely Gain-of-function 26000489, 16432180 +PIK3CB N553S Likely Oncogenic Likely Gain-of-function 18755892, 26000489 +PIK3CB D1067Y Oncogenic Gain-of-function 26759240 +PIK3CB Fusions Likely Oncogenic Likely Gain-of-function 26000489, 16432180 +PIK3CB Amplification Oncogenic Gain-of-function 24418330, 26442967, 16432180, 25533673 +PIM1 E142D Inconclusive Inconclusive 23755147 +PIM1 P123M Likely Neutral Likely Neutral 15808862 +PIM1 L193F Likely Oncogenic Likely Loss-of-function 15808862 +PIM1 N82K Likely Neutral Likely Loss-of-function 15808862 +PIM1 P81S Likely Oncogenic Likely Loss-of-function 15808862 +PIM1 Y53H Inconclusive Inconclusive 23755147 +PIM1 E124Q Inconclusive Inconclusive 23755147 +PIM1 H68Y Likely Oncogenic Likely Gain-of-function 15808862 +PIM1 E135K Inconclusive Inconclusive 23755147, 15808862, 19734423 +PIK3CD E525K Likely Oncogenic Gain-of-function 24136356, 24165795 +PIK3CD E1021K Likely Oncogenic Gain-of-function 24136356, 24165795 +PIK3CD N334K Likely Oncogenic Gain-of-function 24165795 +YAP1 Fusions Likely Oncogenic Likely Gain-of-function 23737213, 25965568, 24553141 +YAP1 Amplification Oncogenic Gain-of-function 16140918, 15586366, 16814713, 24336504, 19952108, 15824737, 8569172, 10092132, 17114655, 20842732, 23502453, 24511017, 12651874, 12208731, 19551889 +YAP1 YAP1-MAMLD1 Fusion Likely Oncogenic Likely Gain-of-function 25965575 +YAP1 YAP1-FAM118B Fusion Likely Oncogenic Likely Gain-of-function 25965575 +YAP1 YAP1-TFE3 Fusion Likely Oncogenic Likely Gain-of-function 23737213 +PIK3R1 E137K Likely Oncogenic Likely Loss-of-function 24367658 +PIK3R1 R574fs Oncogenic Loss-of-function 20713702 +PIK3R1 R348* Oncogenic Loss-of-function 21478295, 25284480, 21984976 +PIK3R1 Deletion Likely Oncogenic Likely Loss-of-function 24229379, 25488983, 25133428 +PIK3R1 W237_Y242del Likely Oncogenic Likely Loss-of-function 24367658 +PIK3R1 T576del Oncogenic Loss-of-function 20713702 +PIK3R1 Q579_L581del Oncogenic Loss-of-function 19962665 +PIK3R1 K379E Oncogenic Loss-of-function 20713702 +PIK3R1 E439del Likely Oncogenic Loss-of-function 20713702 +PIK3R1 R262T Likely Oncogenic Likely Loss-of-function 24367658 +PIK3R1 X434_splice Likely Oncogenic Loss-of-function 25488983, 25133428 +PIK3R1 N564D Oncogenic Loss-of-function 24367658 +PIK3R1 D560Y Likely Oncogenic Loss-of-function 20713702 +PIK3R1 R503W Oncogenic Loss-of-function 25957691, 21984976 +PIK3R1 G376R Likely Oncogenic Loss-of-function 20713702 +PIK3R1 X475_splice Likely Oncogenic Loss-of-function 25488983, 25133428 +PIK3R1 E218* Likely Oncogenic Likely Loss-of-function 24367658 +PIK3R1 K459_S460delinsN Oncogenic Loss-of-function 20713702 +PIK3R1 R162* Likely Oncogenic Likely Loss-of-function 24367658 +PIK3R1 E160* Oncogenic Loss-of-function 25284480, 21984976 +PIK3R1 Truncating Mutations Likely Oncogenic Likely Loss-of-function 25488983, 25284480, 25133428 +PIK3R1 X582_splice Likely Oncogenic Likely Loss-of-function 25488983, 25284480, 25133428 +PIK3R1 N564K Likely Oncogenic Loss-of-function 20713702 +PIK3R1 K288Q Likely Oncogenic Likely Loss-of-function 24367658 +PIK3R1 L370fs Likely Oncogenic Likely Loss-of-function 25284480 +PIK3R1 I559_D560insDKRMNS Oncogenic Loss-of-function 20713702 +PIK3R2 A36E Likely Neutral Likely Neutral 21984976 +PIK3R2 A171V Oncogenic Gain-of-function 21984976 +PIK3R2 K376N Inconclusive Inconclusive 21984976 +PIK3R2 N561D Oncogenic Gain-of-function 21984976 +PIK3R2 G373R Likely Oncogenic Gain-of-function 26520804, 22729224 +PIK3R2 Amplification Likely Oncogenic Likely Gain-of-function 25502460 +PIK3R2 A727V Likely Neutral Likely Neutral 21984976 +PIK3R2 D557H Likely Oncogenic Likely Loss-of-function 26860062, 26520804 +PIK3R2 S273C Likely Neutral Likely Neutral 21984976 +ARID5B Truncating Mutations Likely Oncogenic Likely Loss-of-function Kawamata and Itakura Abstract# LB-150, AACR 2016 http://cancerres.aacrjournals.org/content/76/14_Supplement/LB-150 +HRAS T58I Likely Oncogenic Likely Gain-of-function 26888048 +HRAS A146T Oncogenic Gain-of-function 17054105, 19075190, 20570890, 20147967, 2403644 +HRAS G13V Likely Oncogenic Likely Gain-of-function 9219684, 21993244, 22589270, 18713003 +HRAS K117N Likely Oncogenic Likely Gain-of-function 20570890 +HRAS G13D Likely Oncogenic Likely Gain-of-function 26561417, 9219684, 26037647, 21993244, 22722830, 20147967 +HRAS F28L Likely Oncogenic Gain-of-function 25600866 +HRAS Q61K Oncogenic Gain-of-function 10574788, 18073111, 9219684, 21993244, 20194776 +HRAS A59G Likely Oncogenic Gain-of-function 17084704, 20838576 +HRAS Q22K Likely Oncogenic Likely Gain-of-function 17412879 +HRAS G12A Likely Oncogenic Likely Gain-of-function 9219684, 21993244, 25013473 +HRAS G12D Oncogenic Gain-of-function 9219684, 21993244, 24123531 +HRAS A59T Likely Oncogenic Likely Gain-of-function 1730690 +HRAS G12S Oncogenic Gain-of-function 9219684, 21993244, 20979192, 25284075, 24129065 +HRAS G12V Oncogenic Gain-of-function 9219684, 21993244, 24240680, 22589270 +HRAS Q61H Likely Oncogenic Likely Gain-of-function 10574788, 25705018, 9219684, 21993244, 20194776, 20147967 +HRAS Q61R Likely Oncogenic Likely Gain-of-function 10574788, 9219684, 21993244, 20194776, 25437878 +HRAS A146V Likely Oncogenic Likely Gain-of-function 18247425 +HRAS Q61L Oncogenic Gain-of-function 22256804, 10574788, 9219684, 21993244, 20194776 +HRAS Amplification Likely Oncogenic Likely Gain-of-function 8221670, 3283542, 1855225 +HRAS G13R Likely Oncogenic Likely Gain-of-function 9219684, 21993244 +HRAS G12C Likely Oncogenic Likely Gain-of-function 25705018, 9219684, 21993244, 24256730, 16051643, 26841430 +HRAS P34R Likely Oncogenic Likely Gain-of-function 16474404, 8246952 +HRAS Y64A Likely Oncogenic Likely Gain-of-function 24516166 +HRAS K117R Oncogenic Gain-of-function 17054105, 16443854, 20570890, 24247240, 20147967 +HRAS G13C Likely Oncogenic Likely Gain-of-function 25705018, 9219684, 21993244, 17211612, 21079152 +MLH1 M587V Inconclusive Inconclusive 18206535 +MLH1 R487* Likely Oncogenic Likely Loss-of-function 24362816, 16216036, 15713769 +MLH1 P648S Inconclusive Inconclusive 23435383, 24362816 +MLH1 G67R Likely Oncogenic Likely Loss-of-function 21120944 +MLH1 V716M Likely Neutral Likely Neutral 24362816, 21120944 +MLH1 L749P Inconclusive Inconclusive 23435383, 24362816 +MLH1 L550P Likely Oncogenic Likely Loss-of-function 23435383, 24362816 +MLH1 L622H Inconclusive Inconclusive 23435383, 24362816 +MLH1 L559R Inconclusive Inconclusive 23435383, 24362816 +MLH1 T117M Likely Oncogenic Loss-of-function 24362816, 8566964, 12919140, 11781295 +MLH1 R659P Inconclusive Inconclusive 23435383 +MLH1 K618T Likely Neutral Likely Neutral 24362816, 19863800 +MLH1 K618A Likely Oncogenic Likely Loss-of-function 22426235, 24362816, 18205192 +MLH1 R659L Likely Oncogenic Likely Loss-of-function 23435383 +MLH1 V384D Likely Neutral Likely Neutral 12037578, 24362816 +MLH1 Q689R Likely Neutral Likely Neutral 24362816, 25092538 +MLH1 A120S Oncogenic Loss-of-function 24755471 +MLH1 R659* Oncogenic Loss-of-function 23435383 +MLH1 I219V Likely Neutral Likely Neutral 24362816, 11781295 +MLH1 P648L Likely Oncogenic Loss-of-function 23435383, 24362816 +MLH1 V506A Inconclusive Inconclusive 23435383, 24362816 +MLH1 R265C Oncogenic Loss-of-function 19419416, 18205192, 11781295 +MLH1 N551T Likely Oncogenic Likely Loss-of-function 23435383, 24362816 +MLH1 R217C Likely Neutral Likely Neutral 12810663, 17510385, 11781295 +MLH1 A111P Likely Oncogenic Likely Loss-of-function 20020535 +MLH1 G67W Likely Oncogenic Loss-of-function 16528606, 24362816, 17510385, 9927034 +MLH1 D737V Inconclusive Inconclusive 23435383, 24362816 +MLH1 E172K Inconclusive Inconclusive 24755471, 20668451 +MLH1 P654L Inconclusive Inconclusive 23435383 +MLH1 Truncating Mutations Likely Oncogenic Likely Loss-of-function 12697830, 7892206, 11781295 +MLH1 T82A Likely Oncogenic Loss-of-function 24362816, 22736432 +MLH1 R265S Likely Oncogenic Likely Loss-of-function 20020535, 17210669, 24362816 +MLH1 W714* Likely Oncogenic Loss-of-function 23435383, 24362816 +MLH1 R725C Inconclusive Inconclusive 24362816, 23403630 +MLH1 G101S Likely Oncogenic Likely Loss-of-function 22290698, 24362816, 24278394 +MLH1 L582F Inconclusive Inconclusive 23435383, 24362816 +MLH1 R100* Likely Oncogenic Loss-of-function 15872200, 14512394 +MLH1 R226* Likely Oncogenic Likely Loss-of-function 11343035, 24362816, 9927033 +MLH1 R755S Likely Oncogenic Likely Loss-of-function 23435383, 24362816 +FGF3 Amplification Inconclusive Inconclusive 24265351, 22890726, 10845805, 9205106 +FGF4 Amplification Inconclusive Inconclusive 24265351, 22890726 +KMT2A Truncating Mutations Likely Oncogenic Likely Loss-of-function 25998713 +KMT2A Fusions Likely Oncogenic Likely Gain-of-function 25998713, 23628958, 8681380, 11265751, 18455126 +KMT2A Amplification Inconclusive Inconclusive 17908926, 15378024 +AKT1 Q79E Oncogenic Gain-of-function 23134728 +AKT1 D32Y Likely Neutral Likely Neutral 23134728, 23237847, 19706770 +AKT1 Amplification Likely Oncogenic Gain-of-function 14655756, 12631397, 1409633, 24896186, 17616691, 3037531, 11485901 +AKT1 R23A Oncogenic Gain-of-function 23134728 +AKT1 W80A Likely Oncogenic Gain-of-function 25856301, 18669636, 25551293 +AKT1 G311D Likely Oncogenic Likely Switch-of-function 25551293, 22460905 +AKT1 V270A Oncogenic Gain-of-function 23134728 +AKT1 E17K Oncogenic Gain-of-function 23134728, 20440266, 23741320, 18256540, 21793738, 17611497, 9843996 +AKT1 K39N Likely Neutral Likely Neutral 23134728, 23237847, 19706770 +AKT1 L362R Likely Neutral Neutral 23134728 +AKT1 E191A Oncogenic Gain-of-function 23134728 +AKT1 L321A Oncogenic Gain-of-function 23134728 +AKT1 L52R Oncogenic Gain-of-function 23134728, 27147599, 20886116 +AKT1 T195I Oncogenic Gain-of-function 23134728 +AKT1 D325A Oncogenic Gain-of-function 23134728 +AKT1 E267G Likely Oncogenic Likely Gain-of-function 27147599 +AKT1 L78T Oncogenic Gain-of-function 23134728 +AKT1 R200A Likely Neutral Neutral 23134728 +AKT1 K189N Oncogenic Gain-of-function 23134728 +AKT1 Q79K Likely Oncogenic Gain-of-function 23134728, 20886116, 24265152 +AKT1 K179M Likely Oncogenic Likely Switch-of-function 7774014, 25551293 +AKT1 C77F Likely Oncogenic Likely Gain-of-function 22722193, 23237847 +AKT1 V271A Oncogenic Gain-of-function 23134728 +AKT1 R370C Likely Oncogenic Likely Gain-of-function 27147599 +AKT1 R328A Oncogenic Gain-of-function 23134728 +AKT1 E49K Oncogenic Gain-of-function 19802009 +AKT1 P42T Likely Neutral Likely Neutral 23134728, 23237847, 19706770 +AKT1 L202F Likely Neutral Neutral 23134728 +AKT1 N53A Oncogenic Gain-of-function 23134728 +AKT1 Q59E Likely Neutral Neutral 23134728 +AKT1 E40K Oncogenic Gain-of-function 9690513, 9843996 +AKT1 D323H Likely Oncogenic Gain-of-function 23134728, 20886116 +AKT2 G161V Likely Oncogenic Switch-of-function 25551293 +AKT2 D399N Likely Oncogenic Gain-of-function 19738612 +AKT2 Amplification Oncogenic Gain-of-function 8622988 +AKT2 E17K Oncogenic Gain-of-function 19372382, 24285683, 21979934, 17611497 +AKT2 I289M Oncogenic Gain-of-function 25551293 +AKT2 R368C Likely Oncogenic Gain-of-function 19738612, 25551293 +AKT2 D32H Likely Oncogenic Gain-of-function 19738612 +AKT2 BCAM-AKT2 Fusion Likely Oncogenic Gain-of-function 25733895 +AKT2 K181M Likely Oncogenic Switch-of-function 25551293 +AKT2 H355M Oncogenic Gain-of-function 25551293 +AKT2 R170W Oncogenic Gain-of-function 25551293 +AKT2 Fusions Likely Oncogenic Likely Gain-of-function 25733895 +FGFR1 E664K Likely Neutral Likely Loss-of-function 19733072 +FGFR1 FGFR1-TACC1 Fusion Oncogenic Gain-of-function 22837387, 23558953 +FGFR1 N546K Oncogenic Gain-of-function 24777483, 24806303, 19224897, 24705251, 22820256, 16186508, 23817572, 24140581, 14602678 +FGFR1 Amplification Oncogenic Gain-of-function 24265351, 23658459, 22960745, 26451490, 15863030, 15863033, 21160078, 24476821, 25677745, 17121884 +FGFR1 ERLIN2?FGFR1 Fusion Likely Oncogenic Gain-of-function 23558953 +FGFR1 BCR-FGFR1 Fusion Likely Oncogenic Gain-of-function 11739186, 20226962 +FGFR1 ZNF198-FGFR1 Fusion Likely Oncogenic Gain-of-function 20226962, 10887137, 10935490 +FGFR1 K656E Likely Oncogenic Gain-of-function 15509736, 23817572 +FGFR1 A263V Likely Neutral Likely Neutral 26826182 +FGFR1 Fusions Likely Oncogenic Likely Gain-of-function 23558953 +FGFR1 FGFR1OP1-FGFR1 Fusion Likely Oncogenic Gain-of-function 11689702, 16690081, 21330321, 20226962 +FGFR1 V561M Likely Oncogenic Likely Gain-of-function 15157880, 25686244 +FGFR1 CEP110-FGFR1 Fusion Likely Oncogenic Gain-of-function 10688839, 20226962 +FGFR1 CUX1-FGFR1 Fusion Likely Oncogenic Gain-of-function 21330321 +FGFR3 FGFR3 - BAIAP2L1 Fusion Oncogenic Gain-of-function 23175443 +FGFR3 I538F Likely Neutral Likely Neutral 26992226 +FGFR3 K650T Likely Oncogenic Likely Gain-of-function 11055896, 19749790 +FGFR3 V555M Likely Oncogenic Gain-of-function 26992226 +FGFR3 P572A Likely Neutral Likely Neutral 26992226 +FGFR3 FGFR3-TACC3 Fusion Oncogenic Gain-of-function 25609060, 22837387 +FGFR3 G380R Likely Oncogenic Gain-of-function 12461689, 10646125, 10611230, 21324899 +FGFR3 I538V Likely Oncogenic Gain-of-function 26992226 +FGFR3 N653H Likely Neutral Likely Neutral 26992226 +FGFR3 G697C Likely Neutral Likely Neutral 26992226 +FGFR3 D646Y Likely Neutral Likely Neutral 26992226 +FGFR3 F384L Likely Neutral Likely Neutral 11157491 +FGFR3 A500T Likely Neutral Likely Neutral 26992226 +FGFR3 K650E Likely Oncogenic Gain-of-function 19749790, 11429702 +FGFR3 H643D Likely Neutral Likely Neutral 26992226 +FGFR3 Y647C Likely Oncogenic Likely Gain-of-function 26992226 +FGFR3 A391E Likely Oncogenic Gain-of-function 23437153 +FGFR3 R669G Likely Oncogenic Gain-of-function 26992226 +FGFR3 V677I Likely Neutral Likely Neutral 26992226 +FGFR3 Y373C Oncogenic Gain-of-function 19749790, 16338952, 11429702 +FGFR3 K650R Likely Oncogenic Likely Gain-of-function 11055896, 19749790 +FGFR3 Fusions Likely Oncogenic Likely Gain-of-function 23298836, 23661334, 23558953 +FGFR3 G370C Likely Oncogenic Gain-of-function 12009017 +FGFR3 D641G Likely Oncogenic Gain-of-function 26992226 +FGFR3 N540K Oncogenic Gain-of-function 26992226 +FGFR3 K650M Likely Oncogenic Likely Gain-of-function 11055896, 19749790, 10053006 +FGFR3 S371C Likely Oncogenic Gain-of-function 12009017 +FGFR3 E466K Likely Neutral Likely Neutral 26992226 +FGFR3 G375C Likely Oncogenic Gain-of-function 22529939 +FGFR3 S249C Oncogenic Gain-of-function 19749790, 16338952, 17384684 +FGFR3 K650Q Likely Oncogenic Likely Gain-of-function 11055896, 19749790 +FGFR3 Amplification Oncogenic Gain-of-function 17344846, 20094046, 19821490 +FGFR3 C582F Likely Neutral Likely Neutral 26992226 +FGFR3 IGH-FGFR3 Fusion Oncogenic Gain-of-function 17107900 +FGFR3 K650N Likely Oncogenic Likely Gain-of-function 11055896, 19749790 +FGFR3 R248C Oncogenic Gain-of-function 22203368, 8640234 +FGFR3 K508M Inconclusive Inconclusive 22837387 +FGFR3 G637W Likely Neutral Likely Loss-of-function 26992226 +FGFR3 E627D Likely Neutral Likely Neutral 26992226 +FGFR3 D641N Likely Oncogenic Gain-of-function 26992226 +FGFR3 D617G Likely Neutral Likely Loss-of-function 26992226 +FGFR3 N540S Likely Oncogenic Gain-of-function 26992226 +FGFR3 G382D Likely Oncogenic Likely Gain-of-function 11429702 +SPOP P94A Likely Oncogenic Loss-of-function 19818708, 18218622, 25766326 +SPOP M117I Likely Oncogenic Loss-of-function 19818708, 18218622, 25766326 +SPOP E47K Likely Oncogenic Loss-of-function 19818708, 18218622, 25766326 +SPOP W131A Likely Oncogenic Likely Loss-of-function 19818708, 18218622 +SPOP F133L Likely Oncogenic Loss-of-function 19818708, 18218622, 25274033, 24508459, 23559371 +SPOP S80R Likely Oncogenic Loss-of-function 19818708, 18218622, 25766326 +SPOP N296I Likely Oncogenic Likely Loss-of-function 19818708, 23559371, 24796539 +SPOP D130A Likely Oncogenic Likely Loss-of-function 19818708, 18218622, 22085717 +SPOP Y87N Likely Oncogenic Loss-of-function 19818708, 18218622, 25274033, 24508459, 23559371 +SPOP F102C Likely Oncogenic Loss-of-function 19818708, 18218622, 25274033, 24508459, 23559371 +SPOP E50K Likely Oncogenic Loss-of-function 19818708, 18218622, 25766326 +SPOP R121Q Likely Oncogenic Loss-of-function 19818708, 18218622, 25766326 +SPOP G75R Likely Oncogenic Loss-of-function 19818708, 18218622, 25766326 +SPOP Y87C Likely Oncogenic Loss-of-function 19818708, 18218622, 25274033, 24508459, 23559371 +SPOP D140G Likely Oncogenic Loss-of-function 19818708, 18218622, 25766326 +SPOP W131G Likely Oncogenic Loss-of-function 19818708, 18218622, 25274033, 24508459, 23559371 +SPOP M117V Likely Oncogenic Loss-of-function 19818708, 18218622, 25766326 +SPOP K134N Likely Oncogenic Likely Loss-of-function 19818708, 18218622, 24990631 +SPOP Truncating Mutations Likely Oncogenic Likely Loss-of-function 26344095 +SPOP F133V Likely Oncogenic Loss-of-function 19818708, 18218622, 25274033, 24508459, 23559371 +SPOP K129E Likely Oncogenic Likely Loss-of-function 19818708, 18218622, 24990631 +SPOP F125V Likely Oncogenic Loss-of-function 19818708, 18218622, 25274033, 24508459, 23559371 +SPOP S119N Likely Oncogenic Loss-of-function 19818708, 18218622, 25274033, 24508459, 23559371 +FGFR2 Y375C Likely Oncogenic Gain-of-function 22585574, 22558232 +FGFR2 C278F Likely Oncogenic Likely Loss-of-function 20004243, 16844695 +FGFR2 H213Y Inconclusive Inconclusive 19147536 +FGFR2 K525E Likely Oncogenic Gain-of-function 17803937 +FGFR2 FGFR2-BICC1 Fusion Oncogenic Gain-of-function 24122810, 23558953 +FGFR2 V564I Oncogenic Gain-of-function 23908597 +FGFR2 FGFR2-MGEA5 Fusion Likely Oncogenic Likely Gain-of-function 24550739 +FGFR2 Amplification Oncogenic Gain-of-function 20094046, 20101236 +FGFR2 I642V Likely Oncogenic Likely Loss-of-function 19147536 +FGFR2 E219K Likely Oncogenic Likely Loss-of-function 19147536 +FGFR2 S267_D273dup Oncogenic Gain-of-function 26048680 +FGFR2 W290_I291delinsC Oncogenic Gain-of-function 26048680 +FGFR2 R203C Likely Oncogenic Gain-of-function 23527311, 15908952 +FGFR2 T341P Likely Oncogenic Gain-of-function 9539778 +FGFR2 FGFR2-FAM76A Fusion Oncogenic Gain-of-function 24563622 +FGFR2 N549T Likely Oncogenic Gain-of-function 17803937 +FGFR2 E565G Likely Oncogenic Gain-of-function 23908597 +FGFR2 FGFR2-TACC3 Fusion Oncogenic Gain-of-function 26048680 +FGFR2 FGFR2-AHCYL1 Fusion Oncogenic Gain-of-function 24122810 +FGFR2 E731K Likely Oncogenic Gain-of-function 21928350 +FGFR2 L617F Likely Oncogenic Gain-of-function 23913723 +FGFR2 M535I Oncogenic Gain-of-function 23908597 +FGFR2 K659N Likely Oncogenic Gain-of-function 17803937, 23527311, 17525745 +FGFR2 T730S Likely Neutral Likely Neutral 26048680 +FGFR2 L770V Inconclusive Inconclusive 19147536 +FGFR2 K517R Likely Neutral Likely Loss-of-function 19147536 +FGFR2 G271E Likely Oncogenic Likely Loss-of-function 19147536 +FGFR2 N549K Oncogenic Gain-of-function 23908597, 17525745, 18552176 +FGFR2 K310R Likely Neutral Likely Neutral 18552176 +FGFR2 L617M Oncogenic Gain-of-function 23908597 +FGFR2 N549H Oncogenic Gain-of-function 23908597 +FGFR2 D530N Likely Oncogenic Likely Loss-of-function 19147536 +FGFR2 A648T Likely Oncogenic Likely Loss-of-function 19147536 +FGFR2 K659E Likely Oncogenic Likely Gain-of-function 17525745 +FGFR2 D101Y Likely Oncogenic Likely Gain-of-function 18552176 +FGFR2 K526E Likely Oncogenic Likely Gain-of-function 17803937, 16061565 +FGFR2 C382R Oncogenic Gain-of-function 9136983, 17525745 +FGFR2 P253R Oncogenic Gain-of-function 24265351, 11121055 +FGFR2 N549S Oncogenic Gain-of-function 23908597 +FGFR2 FGFR2-KIAA1967 Fusion Likely Oncogenic Likely Gain-of-function 23558953 +FGFR2 Fusions Likely Oncogenic Likely Gain-of-function 25608663, 26258846, 23558953 +FGFR2 K641N Likely Oncogenic Likely Gain-of-function 23908597 +FGFR2 S252W Oncogenic Gain-of-function 17525745, 18552176 +FGFR2 M391R Likely Oncogenic Gain-of-function 24908667 +FGFR2 FGFR2-CCDC6 Fusion Likely Oncogenic Gain-of-function 23558953 +FGFR2 A389T Likely Neutral Likely Neutral 18552176 +FGFR2 V248D Inconclusive Inconclusive 19147536 +FGFR2 V755I Likely Neutral Likely Neutral 26048680 +FGFR2 FGFR2-CIT Fusion Likely Oncogenic Likely Gain-of-function 23558953 +FGFR2 G701S Inconclusive Inconclusive 19147536 +FGFR2 E475K Likely Neutral Likely Neutral 19147536 +FGFR2 FGFR2?PPHLN1 Fusion Oncogenic Gain-of-function 25608663 +FGFR2 R251Q Likely Oncogenic Likely Loss-of-function 19147536 +FGFR2 K641R Likely Oncogenic Gain-of-function 17803937, 23527311 +FGFR2 E636K Inconclusive Inconclusive 19147536 +FGFR4 Y367C Oncogenic Gain-of-function 19946327 +FGFR4 Amplification Oncogenic Gain-of-function 15863030, 25053532, 20094046, 23344261 +FGFR4 V550E Oncogenic Gain-of-function 19809159, 25219510 +FGFR4 N535K Oncogenic Gain-of-function 19809159 +KDM6A Deletion Likely Oncogenic Likely Loss-of-function 19330029, 25225064, 27028180, 22197486 Walker et al. Abstract #1798, ASH, 2009 http://www.bloodjournal.org/content/114/22/1798?sso-checked=true +KDM6A Truncating Mutations Likely Oncogenic Likely Loss-of-function 19330029, 24633898, 25225064 +ALK I1183T Likely Neutral Neutral 21383740, 25517749 +ALK G1202R Oncogenic Gain-of-function 22277784, 21383740, 26144315, 26698910, 24736079, 24675041 +ALK RANBP2-ALK Fusion Oncogenic Gain-of-function 21030459, 20979472 +ALK G1269S Oncogenic Gain-of-function 22277784, 21383740, 22034911, 24675041 +ALK L1198P Oncogenic Gain-of-function 21948233, 21383740 +ALK L1122V Oncogenic Gain-of-function 21383740, 25421750 +ALK I1171N Oncogenic Gain-of-function 21383740, 25517749, 27049722, 24491302, 25749034 +ALK T1343I Likely Neutral Likely Neutral 21383740, 25517749 +ALK S1206Y Oncogenic Gain-of-function 22277784, 21383740, 26144315, 24675041 +ALK N1178H Oncogenic Gain-of-function 21383740, 25749034 +ALK P1139S Oncogenic Gain-of-function 21383740, 25421750 +ALK RANBP1-ALK Fusion Oncogenic Gain-of-function 21030459 +ALK D1091N Likely Oncogenic Likely Gain-of-function 21383740, 18923525, 23104988, 26786851, 18724359 +ALK H694R Likely Oncogenic Gain-of-function 21847362 +ALK R1192P Oncogenic Gain-of-function 27009859, 21383740, 25517749, 27049722 +ALK G1269A Oncogenic Gain-of-function 22235099, 27009859, 26849637, 23401436, 21948233, 22277784, 21383740, 27049722, 26144315, 26698910, 24675041 +ALK R1464* Likely Neutral Neutral 21383740, 23104988 +ALK S1206C Oncogenic Gain-of-function 21383740, 25421750 +ALK A1234T Likely Neutral Likely Neutral 21383740, 23104988 +ALK V597A Likely Oncogenic Gain-of-function 21847362, 12855999 +ALK R1275L Likely Oncogenic Likely Gain-of-function 23598171 +ALK G1128S Oncogenic Gain-of-function 25749034 +ALK L1240V Oncogenic Gain-of-function 21383740, 23104988 +ALK G1201E Oncogenic Gain-of-function 21383740, 21596819 +ALK R1275Q Oncogenic Gain-of-function 18923523, 21383740, 18923525, 25517749, 26829053, 27049722, 26554404, 22072639 +ALK D1349H Likely Neutral Likely Neutral 21383740, 25517749 +ALK L1152R Oncogenic Gain-of-function 21791641, 21383740, 26144315 +ALK STRN-ALK Fusion Likely Oncogenic Likely Gain-of-function 24613930 +ALK G1128A Oncogenic Gain-of-function 21383740, 25517749, 27049722 +ALK L1196M Oncogenic Gain-of-function 22235099, 23434628, 22277784, 21383740, 25517749, 26144315, 20979473, 26698910, 22034911, 25421750, 21613408, 24675041 +ALK NPM-ALK Fusion Oncogenic Gain-of-function 26133723, 18923525, 26144315, 12424201, 25421750, 12879008, 21613408 +ALK G881D Likely Oncogenic Gain-of-function 21847362 +ALK F1245V Oncogenic Gain-of-function 21383740, 25517749 +ALK C1156F Oncogenic Gain-of-function 21383740, 25749034 +ALK C1156Y Oncogenic Gain-of-function 22235099, 21383740, 26144315, 20979473, 26698910, 25749034, 21613408, 24675041 +ALK Q1064R Oncogenic Gain-of-function 21383740, 25421750 +ALK G1123D Oncogenic Gain-of-function 21948233, 21383740 +ALK I1170S Oncogenic Gain-of-function 21383740, 25517749 +ALK I1250T Likely Neutral Likely Neutral 21383740, 25517749 +ALK E1384K Likely Oncogenic Gain-of-function 21847362 +ALK L1204F Likely Neutral Neutral 21383740, 23104988 +ALK M1328I Oncogenic Gain-of-function 21383740, 24491302 +ALK F1174V Oncogenic Gain-of-function 18923523, 21383740, 27049722, 25421750 +ALK I1171T Oncogenic Gain-of-function 25228534, 21383740, 22034911, 25749034, 24675041, 25736571 +ALK G1286R Likely Neutral Neutral 21383740, 25517749 +ALK I1170N Oncogenic Gain-of-function 21383740, 25517749 +ALK K1062M Oncogenic Gain-of-function 21383740, 21596819, 18923524 +ALK D1203N Likely Oncogenic Likely Gain-of-function 21948233, 25421750, 25749034 +ALK E1210K Oncogenic Gain-of-function 21383740, 22034911 +ALK T1151R Likely Oncogenic Likely Gain-of-function 25071110, 21383740 +ALK KIF5B-ALK Fusion Likely Oncogenic Gain-of-function 26144315, 21613408 +ALK Fusions Likely Oncogenic Likely Gain-of-function 24060861 +ALK F1174S Oncogenic Gain-of-function 21383740, 23104988 +ALK D1270G Likely Neutral Neutral 21383740, 25517749 +ALK Amplification Likely Oncogenic Likely Gain-of-function 21474455, 24356251, 22614325 +ALK F1245C Oncogenic Gain-of-function 21383740, 25517749, 27049722, 26554404, 22034911, 23598171 +ALK A1200V Likely Neutral Neutral 21383740, 23104988 +ALK L1198F Oncogenic Gain-of-function 21383740, 21596819, 26698910, 25421750 +ALK Y1278S Oncogenic Gain-of-function 25071110, 21383740, 25517749, 27049722, 23598171 +ALK F1174L Oncogenic Gain-of-function 21383740, 25517749, 22072639, 18724359, 21030459, 18923523, 27009859, 21948233, 21596819, 20719933, 18923525, 27049722, 26144315, 26554404, 23104988, 18923524, 26786851, 21242967, 21613408 +ALK R1060H Likely Neutral Neutral 21383740, 23104988 +ALK EML4-ALK Fusion Oncogenic Gain-of-function 21030459, 22235099, 25228534, 21791641, 21948233, 22277784, 18923524, 21613408, 24675041 +ALK V1180L Oncogenic Gain-of-function 25228534, 21383740 +ALK M1166R Oncogenic Gain-of-function 21383740, 25517749, 23104988 +ALK G1123S Oncogenic Gain-of-function 21948233, 21383740 +ALK L1152P Oncogenic Gain-of-function 21383740, 24675041 +ALK T1151M Likely Neutral Likely Neutral 27009859, 21383740, 18923525, 25517749, 23104988 +ALK T1151dup Oncogenic Gain-of-function 22277784, 21383740, 26144315, 24675041 +ALK R1231Q Likely Neutral Neutral 21383740, 23104988 +ALK A1099T Likely Neutral Neutral 21383740, 23104988 +ALK I1171S Oncogenic Gain-of-function 27009859, 21383740, 26464158 +ALK S1206R Oncogenic Gain-of-function 21383740, 22034911 +ALK F1174I Oncogenic Gain-of-function 21383740, 23104988, 25749034 +ALK L1196Q Oncogenic Gain-of-function 23239810 +ALK CAD-ALK Fusion Likely Oncogenic Likely Gain-of-function 26633560 +ALK F1174C Oncogenic Gain-of-function 21383740, 26698910, 22034911, 24675041 +ALK T1087I Likely Neutral Neutral 21383740, 23104988 +SDHB S100F Likely Oncogenic Loss-of-function 17639058, 15987702 +RAD54L G325R Likely Oncogenic Loss-of-function 15056673, 10362365 +SDHC R133* Likely Oncogenic Loss-of-function 24423348 +VEGFA Amplification Likely Oncogenic Gain-of-function 24687604, 21743435, 24114200, 21495021 +MPL S505N Likely Oncogenic Likely Gain-of-function 14764528, 8695859 +MPL W515L Oncogenic Gain-of-function 16834459 +MPL W515K Likely Oncogenic Likely Gain-of-function 16868251, 17709604 +MPL P106L Likely Oncogenic Likely Gain-of-function 25538044, 23351976 +PMS1 Q233* Oncogenic Loss-of-function 8072530 +CARM1 S217E Likely Oncogenic Likely Loss-of-function 19843527 +CARM1 S217C Likely Oncogenic Likely Loss-of-function 19843527 +CARM1 S217T Likely Oncogenic Likely Loss-of-function 19843527 +CARM1 S217A Likely Oncogenic Likely Loss-of-function 19843527 +FOXO1 T24A Likely Oncogenic Likely Loss-of-function 17646672, 16670091 +VHL H115R Likely Oncogenic Loss-of-function 24969085 +VHL L158P Likely Oncogenic Loss-of-function 10535940, 10973499, 19602254 +VHL N90I Likely Oncogenic Loss-of-function 10823831 +VHL S111C Likely Oncogenic Loss-of-function 22071692 +VHL R167Q Oncogenic Loss-of-function 10535940, 24755468, 19030229 +VHL L188Q Likely Oncogenic Loss-of-function 19602254 +VHL L63P Likely Oncogenic Loss-of-function 15611064 +VHL Y98N Likely Oncogenic Likely Loss-of-function 10823831, 10535940 +VHL P25L Likely Neutral Likely Neutral 16884327 +VHL L188V Likely Oncogenic Likely Loss-of-function 10823831 +VHL V84L Inconclusive Inconclusive 10823831 +VHL Truncating Mutations Likely Oncogenic Likely Loss-of-function 21386872, 12050673, 12004076, 22825683 +VHL F119S Likely Oncogenic Likely Loss-of-function 14636579 +VHL S68W Likely Oncogenic Loss-of-function 18544564, 15611064 +VHL Deletion Oncogenic Likely Loss-of-function 21386872, 23632291, 25093046, 19764026 +VHL L158V Likely Oncogenic Loss-of-function 19602254 +VHL L128F Likely Neutral Likely Neutral 11865071 +VHL P86H Likely Oncogenic Loss-of-function 10823831, 10535940 +VHL R167W Oncogenic Loss-of-function 25563310, 14973063, 23824745, 12202531 +VHL V155A Likely Oncogenic Loss-of-function 26503325 +VHL A149P Likely Oncogenic Likely Loss-of-function 14636579 +VHL L118P Likely Oncogenic Likely Loss-of-function 14636579 +VHL R64P Likely Oncogenic Loss-of-function 10823831, 15611064 +VHL I151S Likely Oncogenic Likely Loss-of-function 14636579, 27179072 +VHL N150K Likely Oncogenic Likely Loss-of-function 14636579 +VHL L118R Likely Oncogenic Likely Loss-of-function 14636579 +VHL Y112H Likely Oncogenic Likely Loss-of-function 10823831 +VHL S65L Likely Oncogenic Loss-of-function 15611064 +VHL S65A Likely Oncogenic Likely Loss-of-function 26619011, 15611064 +VHL Q164R Likely Oncogenic Loss-of-function 26503325 +VHL Q96P Likely Oncogenic Loss-of-function 10823831 +VHL W117C Likely Oncogenic Loss-of-function 14636579 +VHL R82P Likely Oncogenic Loss-of-function 10823831 +VHL Q145H Likely Neutral Loss-of-function 15611064 +VHL N78S Likely Oncogenic Loss-of-function 19602254 +VHL D121G Likely Oncogenic Likely Loss-of-function 26619011, 11865071 +VHL L158Q Likely Oncogenic Loss-of-function 2706960 +VHL E70K Likely Oncogenic Likely Loss-of-function 15611064 +VHL R69C Likely Oncogenic Loss-of-function 15611064 +VHL G114R Likely Oncogenic Likely Loss-of-function 14636579, 27179072 +VHL H191D Oncogenic Loss-of-function 21685897 +VHL S65W Likely Oncogenic Loss-of-function 15611064 +VHL H115Q Likely Oncogenic Likely Loss-of-function 24969085, 12202531 +VHL Y98H Likely Oncogenic Likely Loss-of-function 10823831 +VHL R200W Oncogenic Loss-of-function 21685897 +MAP2K4 R304* Likely Oncogenic Loss-of-function 21896780 +MAP2K4 R134Q Likely Oncogenic Likely Gain-of-function 21896780, 26619011 +MAP2K4 N234I Oncogenic Loss-of-function 20668451, 15122334 +MAP2K4 R154W Oncogenic Loss-of-function 20668451, 15122334 +MAP2K4 S251N Oncogenic Loss-of-function 20668451, 15122334 +MAP2K4 Truncating Mutations Likely Oncogenic Likely Loss-of-function 21896780 +MAP2K4 R228K Oncogenic Loss-of-function 20668451, 15122334 +MAP2K4 A279T Oncogenic Loss-of-function 21896780, 20668451, 15122334 +MAP2K4 V321M Likely Oncogenic Loss-of-function 21896780 +MAP2K4 P326L Likely Oncogenic Loss-of-function 21896780 +MAP2K4 G85R Oncogenic Loss-of-function 20668451, 15122334 +RRAS2 Q72L Oncogenic Gain-of-function 8052619 +FLT1 Amplification Inconclusive Inconclusive Zehir A et al. Nature Medicine, 2017 http://doi:10.1038/nm.4333 +FLT3 D835Y Oncogenic Gain-of-function 11290608, 23631653, 15256420, 26108694, 24255108 +FLT3 V592G Oncogenic Gain-of-function 18068628 +FLT3 D835V Oncogenic Gain-of-function 11290608, 15256420, 26108694 +FLT3 Y599_D600insPAPQIMSTSTLISENMNIA Oncogenic Gain-of-function 9737679, 11090077, 23631653 +FLT3 K602_W603insYEYDLK Oncogenic Gain-of-function 9737679, 11090077, 23631653 +FLT3 E598_Y599insGLVQVTGSSDNEYFYVDFREYE Oncogenic Gain-of-function 9737679, 11090077, 23631653, 11756186 +FLT3 F594L Oncogenic Gain-of-function 16410449 +FLT3 M664I Likely Oncogenic Likely Gain-of-function 25847190 +FLT3 I867S Oncogenic Gain-of-function 24608088 +FLT3 Y599F Likely Neutral Likely Loss-of-function 16684964 +FLT3 W603_E604insDREYEYDLKW Oncogenic Gain-of-function 9737679, 11090077, 23631653 +FLT3 E612_F613insGYVDFREYEYDLKWEFRPRENLEF Oncogenic Gain-of-function 9737679, 11090077, 23631653, 11756186 +FLT3 D835E Oncogenic Gain-of-function 11290608, 15256420, 26108694 +FLT3 V194M Likely Neutral Neutral 18068628 +FLT3 D324N Likely Neutral Neutral 18068628 +FLT3 E598_Y599insDVDFREYE Oncogenic Gain-of-function 9737679, 11090077, 23631653 +FLT3 A627T Likely Oncogenic Likely Gain-of-function 15374944 +FLT3 I836del Likely Oncogenic Gain-of-function 23878140 +FLT3 D835H Oncogenic Gain-of-function 11290608, 15256420, 26108694 +FLT3 F594_R595insSDNEYFYVDF Oncogenic Gain-of-function 9737679, 11090077, 23631653 +FLT3 S451F Oncogenic Gain-of-function 18068628 +FLT3 Y591D Oncogenic Gain-of-function 16410449 +FLT3 V592A Oncogenic Gain-of-function 16410449 +FLT3 N676K Oncogenic Gain-of-function 23878140 +FLT3 L601_K602insREYEYDL Oncogenic Gain-of-function 9737679, 11090077, 23631653, 11756186 +FLT3 T167A Likely Neutral Neutral 18068628 +FLT3 S840_N841insGS Oncogenic Gain-of-function 9737679, 11090077, 23631653, 12384447 +FLT3 D835del Oncogenic Gain-of-function 15256420 +FLT3 Y364H Likely Neutral Neutral 18068628 +FLT3 K868N Likely Neutral Loss-of-function 27272783 +FLT3 N841I Oncogenic Gain-of-function 15178581 +FLT3 Y572C Oncogenic Gain-of-function 18068628 +FLT3 V557I Likely Neutral Neutral 18068628 +FLT3 D835N Oncogenic Gain-of-function 11290608, 15256420, 26108694 +FLT3 F590G Oncogenic Gain-of-function 16410449 +FLT3 D839G Oncogenic Gain-of-function 24608088 +FLT3 Y599_D600insSTDNEYFYVDFREYEY Oncogenic Gain-of-function 9737679, 11090077, 23631653 +FLT3 N676S Likely Oncogenic Likely Gain-of-function 25847190 +FLT3 V579A Oncogenic Gain-of-function 16410449 +FLT3 D600_L601insDFREYEYD Oncogenic Gain-of-function 9737679, 11090077, 23631653 +FLT3 Y599_D600insEYEYEYEY Oncogenic Gain-of-function 9737679, 11090077, 23631653 +FLT3 D835A Oncogenic Gain-of-function 11290608, 15256420, 26108694 +FLT3 L611_E612insCSSDNEYFYVDFREYEYDLKWEFPRENL Oncogenic Gain-of-function 9737679, 11090077, 23631653, 11756186 +FLT3 R834Q Oncogenic Gain-of-function 18068628 +FLT3 Amplification Likely Oncogenic Gain-of-function 25848357, 27906677 +FLT3 FLT3 internal tandem duplications Oncogenic Gain-of-function 23631653 +FLT3 N676D Likely Oncogenic Likely Gain-of-function 22875611 +FLT3 S451E Oncogenic Gain-of-function 18068628 +FLT3 F691L Oncogenic Gain-of-function 19318574, 23430109 +FLT3 Y842C Oncogenic Gain-of-function 15345593 +FLT3 G831E Likely Neutral Neutral 18068628 +FLT3 M737I Likely Neutral Neutral 18068628 +FLT3 Y599_D600insGLYVDFREYEY Oncogenic Gain-of-function 9737679, 11090077, 23631653, 11756186 +FLT3 D600_L601insFREYEYD Oncogenic Gain-of-function 9737679, 11090077, 23631653 +PMS2 G207E Likely Oncogenic Likely Loss-of-function 19479271, 24027009 +PMS2 T485K Likely Neutral Likely Neutral 15256438, 24362816, 24027009 +PMS2 Truncating Mutations Likely Oncogenic Likely Loss-of-function 12697830, 20487569, 23582141, 21376568, 7892206, 16144131, 9488480 +PMS2 R20Q Oncogenic Loss-of-function 25512458 +PMS2 G857A Likely Neutral Likely Neutral 24362816, 24027009 +PMS2 L585I Likely Neutral Likely Neutral 24362816, 24027009 +PMS2 R802* Likely Oncogenic Likely Loss-of-function 24362816, 16507833 +PMS2 R421* Likely Oncogenic Likely Loss-of-function 24362816 +PMS2 I668V Oncogenic Loss-of-function 25691505 +PMS2 E541K Likely Neutral Likely Neutral 24362816, 24027009 +PMS2 E41A Oncogenic Loss-of-function 20864418, 24027009 +PMS2 R315* Likely Oncogenic Likely Loss-of-function 24362816 +PMS2 S46I Oncogenic Loss-of-function 18602922, 25883011, 23709753, 17557300, 24027009, 2257789, 18709565, 16144131 +PMS2 P470S Likely Neutral Likely Neutral 24362816, 24027009 +PMS2 S46N Oncogenic Loss-of-function 24027009 +PMS2 Deletion Likely Oncogenic Likely Loss-of-function 18602922, 23837913, 16472587 +PMS2 E5K Likely Neutral Likely Neutral 24362816 +PMS2 I18V Likely Neutral Neutral 24362816, 24027009 +SRSF2 P95H Oncogenic Loss-of-function 27135740, 25965569, 26124281, 26261309 +WHSC1 E1099K Oncogenic Gain-of-function 23823660, 24076604 +PPM1D 422_605trunc Likely Oncogenic Gain-of-function 25742468, 24880341, 23907125 +POLD1 Truncating Mutations Likely Oncogenic Likely Loss-of-function +POLE L424V Likely Oncogenic Loss-of-function 23263490, 25228659 +POLE P286H Likely Oncogenic Loss-of-function 25228659 +POLE S459F Likely Oncogenic Loss-of-function 25228659 +POLE S279Y Likely Oncogenic Likely Loss-of-function 25228659, 24472300 +POLE F367S Likely Oncogenic Loss-of-function 21157497, 25228659 +POLE P286S Likely Oncogenic Loss-of-function 25228659 +POLE L424I Likely Oncogenic Loss-of-function 25228659 +POLE V411L Likely Oncogenic Loss-of-function 25228659, 23636398 +POLE S297F Likely Oncogenic Likely Loss-of-function 25228659, 24472300 +POLE S459del Likely Oncogenic Likely Loss-of-function 25228659 +POLE P286R Likely Oncogenic Loss-of-function 25228659, 23636398 +KNSTRN R11K Likely Oncogenic Likely Loss-of-function 25194279 +KNSTRN S24F Oncogenic Loss-of-function 25194279 +KNSTRN P26S Likely Oncogenic Likely Loss-of-function 25194279 +KNSTRN A40E Likely Oncogenic Likely Loss-of-function 25194279 +KNSTRN P28S Likely Oncogenic Likely Loss-of-function 25194279 +PIK3R3 Truncating Mutations Likely Oncogenic Likely Loss-of-function 25424831, 27766312 +APC Truncating Mutations Likely Oncogenic Likely Loss-of-function 11062151, 15561772, 11257105 +APC R640G Oncogenic Loss-of-function 19111562 +APC Deletion Likely Oncogenic Likely Loss-of-function 8259511, 15643602, 25317407, 11867715 +APC N1026S Likely Oncogenic Loss-of-function 18166348 +APC I1307K Likely Oncogenic Likely Loss-of-function 9724771 +APC A290T Likely Oncogenic Likely Loss-of-function 11606402 +RICTOR Amplification Oncogenic Gain-of-function 19934294, 20978191, 26370156, 19185849 +MSH2 Deletion Likely Oncogenic Likely Loss-of-function 9823339, 21970482, 22781090, 23264089, 17250661 +MSH2 Q395* Oncogenic Loss-of-function 24362816 +MSH2 G322D Likely Neutral Likely Neutral 24362816 +MSH2 R389* Oncogenic Loss-of-function 19459153, 26864202, 25430799 +MSH2 Q337* Oncogenic Loss-of-function 24362816 +MSH2 A636P Likely Oncogenic Likely Loss-of-function 12595050, 10528862 +MSH2 R711* Oncogenic Loss-of-function 24362816 +MSH2 R680* Oncogenic Loss-of-function 24362816 +MSH2 L390F Likely Neutral Likely Neutral 24362816 +MSH2 A272V Likely Neutral Likely Neutral 17101317, 21120944 +MSH2 D603N Oncogenic Loss-of-function 21120944, 18951462 +MSH2 S860L Likely Neutral Likely Neutral 24362816, 22102614 +MSH2 S723F Likely Oncogenic Likely Loss-of-function 24362816, 22102614, 26951660 +MSH2 G751R Likely Oncogenic Loss-of-function 24362816, 10732761, 17720936 +MSH2 Truncating Mutations Likely Oncogenic Likely Loss-of-function 11257106, 23391514, 15528792, 10946232 +MSH2 Q429* Oncogenic Loss-of-function 7726159 +MSH2 E580* Oncogenic Loss-of-function 24362816 +MSH2 R383* Oncogenic Loss-of-function 8592341 +MSH2 D603G Inconclusive Inconclusive 24362816 +MSH2 R621* Oncogenic Loss-of-function 8566964 +MSH2 W345* Oncogenic Loss-of-function 24362816 +MSH2 Q816* Oncogenic Loss-of-function 24362816 +MSH2 E483* Oncogenic Loss-of-function 24362816 +IDH1 R132G Oncogenic Switch-of-function 23264629, 23630074, 19935646 +IDH1 G97D Likely Oncogenic Switch-of-function 21996744 +IDH1 E190K Likely Neutral Likely Neutral 27147599 +IDH1 G70D Likely Neutral Loss-of-function 21996744 +IDH1 H133Q Likely Neutral Likely Neutral 21996744 +IDH1 A134D Likely Neutral Loss-of-function 21996744 +IDH1 R132H Oncogenic Switch-of-function 25730874, 23393090, 22763442, 22343901, 23630074, 22343889, 22899282, 19935646 +IDH1 I99M Likely Neutral Likely Neutral 21996744 +IDH1 P33S Likely Neutral Likely Neutral 27147599 +IDH1 Y139D Likely Oncogenic Gain-of-function 21996744 +IDH1 R132S Likely Oncogenic Switch-of-function 21760534, 25257301, 23630074, 21912393, 22033490, 19935646 +IDH1 R49C Likely Neutral Loss-of-function 21996744 +IDH1 R132C Oncogenic Switch-of-function 23630074, 23954893, 19935646 +IDH1 V294M Likely Neutral Likely Neutral 21996744 +IDH1 G123R Likely Neutral Loss-of-function 20171178 +IDH1 R100A Likely Oncogenic Switch-of-function 21996744 +IDH1 I130M Likely Neutral Likely Neutral 21996744 +IDH1 R132Q Likely Oncogenic Likely Switch-of-function 25730874, 23630074, 19935646 +IDH2 R172M Likely Oncogenic Likely Switch-of-function 27147599, 20171147 +IDH2 R172K Oncogenic Switch-of-function 20171147, 25043045 +IDH2 R172G Likely Oncogenic Likely Switch-of-function 21641335, 20171147 +IDH2 R140Q Oncogenic Switch-of-function 20692206, 23264629, 20171147, 25043045, 24440599, 20847235 +IDH2 R172S Oncogenic Switch-of-function 23264629, 20171147 +XPO1 E571K Likely Oncogenic Likely Gain-of-function 21741593, 21642962, 27312795, 26619011, 27479820 +XPO1 C528S Inconclusive Inconclusive 27680702, 23034282 +XRCC2 Deletion Likely Neutral Likely Loss-of-function 22464251, 14678973, 10517641 +XRCC2 R188H Likely Oncogenic Likely Loss-of-function 12023985 +XRCC2 Truncating Mutations Likely Oncogenic Likely Loss-of-function 22464251, 14678973, 10517641 +CREBBP W1502A Likely Oncogenic Loss-of-function 11691934, 21390130 +CREBBP Deletion Likely Oncogenic Likely Loss-of-function 21390130 +CREBBP R1563S Likely Neutral Likely Neutral 21390130 +CREBBP Truncating Mutations Likely Oncogenic Likely Loss-of-function 21390130 +CREBBP R1446C Likely Oncogenic Likely Loss-of-function 21390130 +CREBBP Q1500P Likely Neutral Likely Neutral 21390130 +CREBBP R1446H Likely Oncogenic Likely Loss-of-function 21390130 +DIS3 R780K Oncogenic Loss-of-function 26193331, 24150935 +AR F877L Oncogenic Gain-of-function 23779130, 23842682, 23580326 +AR G248V Inconclusive Inconclusive 25500996 +AR L57Q Likely Neutral Loss-of-function 22403669 +AR G216R Inconclusive Inconclusive 25500996 +AR W742C Oncogenic Gain-of-function 12517791 +AR T878A Oncogenic Gain-of-function 9092797, 2260966, 10363963, 9815822, 25320358 +AR A159T Likely Neutral Likely Loss-of-function 25500996 +AR T878S Oncogenic Gain-of-function 9092797, 2260966, 9815822 +AR Q58_Q59insL Likely Neutral Likely Loss-of-function 25500996 +AR P380R Inconclusive Inconclusive 25500996 +AR Amplification Oncogenic Gain-of-function 7795646, 7511045, 11306464, 12888829, 14702632, 10496349 +AR F876L Likely Oncogenic Likely Gain-of-function 23779130, 2384268 +AR Q58L Inconclusive Inconclusive 12801573, 23637914, 24737579 +AR AR-V7 Oncogenic Gain-of-function 20823238, 19117982, 24449822, 22014572, 23851510, 21552559, 19244107, 20644256 +AR L702H Oncogenic Gain-of-function 11956172, 10835690 +AR W742L Oncogenic Gain-of-function 12517791 +AR H875Y Oncogenic Gain-of-function 9092797, 9815822 +AR L272F Likely Neutral Likely Neutral 25500996 +AR N235K Likely Neutral Likely Loss-of-function 25500996, 11422119 +AR ARv567es Oncogenic Gain-of-function 20823238, 19117982, 24449822, 22014572, 23851510, 21552559, 19244107, 20644256 +AR L57del Likely Neutral Likely Neutral 25500996 +AR Q120E Likely Neutral Likely Neutral 25500996 +ARAF S214F Oncogenic Gain-of-function 24569458, 15520807 +ARAF F351L Oncogenic Gain-of-function 24652991 +ARAF S214C Oncogenic Gain-of-function 24569458, 15520807 +ARAF G322S Likely Oncogenic Gain-of-function 25608663, 24569458 +ARAF S214A Likely Oncogenic Likely Gain-of-function 24569458, 26566875, 15520807 +ARAF Q347_A348del Oncogenic Gain-of-function 24652991 +ARAF S214T Likely Oncogenic Gain-of-function 24569458, 15520807 +ARAF N217I Oncogenic Gain-of-function 25608663, 15520807 +RHOA G17V Oncogenic Loss-of-function 24413737, 24584070 +RHOA E40L Likely Oncogenic Likely Gain-of-function 26619011, 9482732 +RHOA T37A Likely Oncogenic Likely Gain-of-function 19147561, 15993039 +RHOA G17E Likely Oncogenic Likely Loss-of-function 24816255 +RHOA Amplification Oncogenic Gain-of-function 10213513, 15448013, 25104222 +RHOA Overexpression Oncogenic Gain-of-function 10213513, 15448013, 25104222 +RHOA E40Q Likely Oncogenic Likely Gain-of-function 26619011, 9565577 +RHOA Y34F Likely Oncogenic Likely Switch-of-function 24398689, 26619011 +RHOA E40T Likely Oncogenic Likely Gain-of-function 26619011, 9482732 +RHOA Y34C Likely Oncogenic Likely Gain-of-function 26619011, 9565577 +RHOA L57V Oncogenic Loss-of-function 24816253 +RHOA Y42C Oncogenic Loss-of-function 9482732, 24816253, 24816255 +RHOA E40W Likely Oncogenic Likely Loss-of-function 26619011, 9482732 +RHOA G17A Likely Oncogenic Loss-of-function 22491204, 12221096, 16472675 +RHOA G14V Likely Neutral Loss-of-function 24584070, 19515453 +RHOA E40N Likely Oncogenic Likely Switch-of-function 26619011, 9482732 +RHOA T19N Likely Oncogenic Loss-of-function 19147561, 24584070 +RHOA R5Q Likely Oncogenic Likely Loss-of-function 25044415 +NCOR1 Truncating Mutations Likely Oncogenic Likely Loss-of-function 21102521, 7566114 +PPP2R1A R183P Likely Oncogenic Likely Loss-of-function 17174897, 17086192, 18922469 +PPP2R1A S256F Likely Oncogenic Likely Loss-of-function 21435433, 17174897, 17086192, 18922469 +PPP2R1A W257C Likely Oncogenic Likely Loss-of-function 21435433, 17174897, 17086192, 18922469 +PPP2R1A R183Q Likely Oncogenic Likely Loss-of-function 17174897, 17086192, 18922469 +PPP2R1A P179L Likely Oncogenic Likely Loss-of-function 17174897, 17086192, 18922469 +PPP2R1A S256W Likely Oncogenic Likely Loss-of-function 21435433, 17174897, 17086192, 18922469 +PPP2R1A R183W Likely Oncogenic Likely Loss-of-function 17174897, 17086192, 18922469 +PPP2R1A S256Y Likely Oncogenic Likely Loss-of-function 21435433, 17174897, 17086192, 18922469 +PPP2R1A W257G Likely Oncogenic Gain-of-function 21435433, 17174897, 17086192, 18922469, 27272709 +PPP2R1A R258C Inconclusive Inconclusive 17174897, 17086192, 18922469 +PPP2R1A R182W Likely Oncogenic Likely Loss-of-function 21435433, 17174897, 17086192, 18922469, 26168268 +PPP2R1A R258H Inconclusive Inconclusive 17174897, 17086192, 18922469 +PPP2R1A P179R Likely Oncogenic Likely Loss-of-function 17174897, 17086192, 18922469 +PPP2R1A R183G Likely Oncogenic Likely Loss-of-function 17174897, 17086192, 18922469 +SETD2 Deletion Oncogenic Loss-of-function 27282254 McKinney et al. Abstract #1052, ASH 2016 https://ash.confex.com/ash/2016/webprogram/Paper96954.html +SETD2 R1625C Oncogenic Loss-of-function 27528607 +SETD2 Truncating Mutations Likely Oncogenic Likely Loss-of-function 24509477, 25728682, 23417712 +IGF1R G119T Likely Oncogenic Loss-of-function 23045302 +IGF1R G1125A Likely Neutral Likely Loss-of-function 20103656 +IGF1R M1255I Likely Oncogenic Likely Gain-of-function 22778948 +IGF1R A1374V Likely Oncogenic Likely Gain-of-function 22778948 +PPP6C R264C Likely Oncogenic Loss-of-function 23729733 +PPP6C P186S Likely Oncogenic Loss-of-function 23729733 +PPP6C H114Y Oncogenic Loss-of-function 23729733 +PPP6C S270L Likely Oncogenic Loss-of-function 23729733 +CTCF H284Y Likely Oncogenic Likely Loss-of-function 11782357, 24794443, 26619011 +CTCF H284N Likely Oncogenic Likely Loss-of-function 11782357, 24794443, 26619011 +CTCF H284P Likely Oncogenic Likely Loss-of-function 11782357, 24794443, 26619011 +CTCF Deletion Likely Oncogenic Likely Loss-of-function 26330387, 24130125, 19568526 +CTCF Truncating Mutations Likely Oncogenic Likely Loss-of-function 25079317, 24130125, 23636398 +CTCF R339W Likely Oncogenic Switch-of-function 11782357 +IKBKE Amplification Likely Oncogenic Likely Gain-of-function 17574021, 25365225 +MTOR L2431P Oncogenic Gain-of-function 22397650 +MTOR R2505P Oncogenic Gain-of-function 20190810, 24631838, 26255626 +MTOR P2476L Likely Neutral Neutral 20190810 +MTOR E2288K Likely Oncogenic Gain-of-function 23322780 +MTOR T1977K Oncogenic Gain-of-function 27482884 +MTOR A1459P Likely Oncogenic Gain-of-function 24631838 +MTOR T1977R Oncogenic Gain-of-function 24631838 +MTOR R2505Q Likely Neutral Neutral 24631838 +MTOR E2419K Oncogenic Gain-of-function 24625776 +MTOR C1483Y Oncogenic Gain-of-function 24631838 +MTOR A41S Likely Neutral Neutral 24631838 +MTOR T1977S Likely Neutral Neutral 24631838 +MTOR L2230V Oncogenic Gain-of-function 27482884 +MTOR L2427R Likely Oncogenic Gain-of-function 27713405 +MTOR S2215F Oncogenic Gain-of-function 24631838 +MTOR D2512H Likely Oncogenic Likely Gain-of-function 24631838 +MTOR A41T Likely Neutral Neutral 24631838 +MTOR A8S Likely Neutral Likely Neutral 20190810 +MTOR M2327I Likely Oncogenic Gain-of-function 27279227 +MTOR F1888L Oncogenic Gain-of-function 24631838 +MTOR R2430M Likely Neutral Neutral 24631838 +MTOR F1888I Likely Oncogenic Gain-of-function 24631838 +MTOR E2014K Likely Oncogenic Gain-of-function 24625776 +MTOR E1799K Oncogenic Gain-of-function 24631838 +MTOR F1888V Likely Neutral Neutral 24631838 +MTOR Y1463S Likely Oncogenic Likely Gain-of-function 24631838, 26255626 +MTOR V2006L Likely Oncogenic Likely Gain-of-function 24631838, 26619011 +MTOR A1519T Oncogenic Gain-of-function 24631838, 26255626 +MTOR D2512Y Likely Neutral Neutral 24631838 +MTOR K1452N Likely Oncogenic Likely Gain-of-function 24631838, 26255626 +MTOR Q2223K Oncogenic Gain-of-function 24622468 +MTOR S2215T Likely Neutral Neutral 24631838 +MTOR L1460P Oncogenic Gain-of-function 20190810, 24631838, 26255626 +MTOR C1483R Likely Oncogenic Gain-of-function 24631838 +MTOR W1456R Likely Oncogenic Likely Gain-of-function 23322780, 22460905 +MTOR P2273S Likely Oncogenic Gain-of-function 23322780 +MTOR R2152C Likely Neutral Neutral 24631838 +MTOR C1483W Likely Oncogenic Gain-of-function 24631838 +MTOR I2500F Oncogenic Gain-of-function 24631838 +MTOR A2034V Likely Oncogenic Likely Gain-of-function 27279227 +MTOR A41P Likely Neutral Neutral 24631838 +MTOR I2500M Oncogenic Gain-of-function 24631838 +MTOR V2006I Likely Oncogenic Gain-of-function 24631838 +MTOR S2215Y Oncogenic Gain-of-function 20190810, 24631838, 24336570 +MTOR L1433S Oncogenic Gain-of-function 24631838, 26255626 +MTOR R2505* Likely Neutral Neutral 24631838 +MTOR F2108L Likely Oncogenic Likely Gain-of-function 27279227 +MTOR C1483F Oncogenic Gain-of-function 24631838, 26255626 +MTOR D2512G Likely Neutral Neutral 24631838 +MTOR T1977I Likely Oncogenic Gain-of-function 26432419 +TET1 Truncating Mutations Likely Oncogenic Likely Loss-of-function 21057493, 22156206, 19372391 +TET1 MLL-TET1 Fusion Oncogenic Gain-of-function 19144982, 12646957, 23818607, 24323992 +TET1 Deletion Likely Oncogenic Likely Loss-of-function 21625234, 19420352, 25867473 +SMARCA4 Truncating Mutations Likely Oncogenic Likely Loss-of-function 24658002, 24658001, 24658004, 25060813, 18301784 +SMARCA4 T910M Likely Oncogenic Loss-of-function 26842758, 23698369 +SMARCA4 R1189* Likely Oncogenic Loss-of-function 20137775 +SMARCA4 R1093* Oncogenic Loss-of-function 24658001, 24658004 +SMARCA4 Deletion Likely Oncogenic Likely Loss-of-function 21520050, 23139211, 18381774, 11481457, 26942101, 11163203 +SMARCA4 R978* Oncogenic Loss-of-function 24658002, 24658004 +SMARCA4 G1232D Likely Oncogenic Loss-of-function 23698369 +SMARCB1 Truncating Mutations Likely Oncogenic Likely Loss-of-function 23620515, 12138206, 9671307, 23435428, 21076395 +SMARCB1 Deletion Likely Oncogenic Likely Loss-of-function 11313485, 10521299, 11095756, 23074045, 9892189, 12450796, 22797305, 11263494 +FOXP1 Truncating Mutations Likely Oncogenic Likely Loss-of-function 25329375 +FOXP1 R514C Likely Oncogenic Likely Loss-of-function 26647308 +SMO Q477E Likely Oncogenic Likely Gain-of-function 25759020, 25759019 +SMO L412F Likely Oncogenic Gain-of-function 2575902, 25759020, 25759019, 25199678 +SMO T241M Likely Oncogenic Gain-of-function 25759019 +SMO I408V Likely Oncogenic Gain-of-function 2575902, 25759020, 25759019, 25199678 +SMO W281C Likely Oncogenic Gain-of-function 25759020, 25759019, 25199678 +SMO V321M Likely Oncogenic Gain-of-function 2575902, 25759020, 25759019, 25199678 +SMO E518K Likely Neutral Likely Neutral 21123452 +SMO L221R Likely Oncogenic Likely Gain-of-function 25759020, 25759019 +SMO S387N Likely Oncogenic Gain-of-function 25759019 +SMO D384N Likely Oncogenic Likely Gain-of-function 25759020, 25759019 +SMO A459V Likely Oncogenic Gain-of-function 25759019 +SMO H231R Likely Oncogenic Likely Gain-of-function 25759020, 25759019 +SMO D473G Likely Oncogenic Likely Gain-of-function 19726788 +SMO F460L Likely Oncogenic Gain-of-function 2575902, 25759020, 25759019, 25199678 +SMO K575M Likely Oncogenic Likely Gain-of-function 16339184, 12499255 +SMO N219D Likely Oncogenic Likely Gain-of-function 25759020, 25759019 +SMO C469Y Likely Oncogenic Gain-of-function 2575902, 25759020, 25759019, 25199678 +SMO E518A Inconclusive Inconclusive 21123452 +SMO W535L Likely Oncogenic Gain-of-function 25759020, 23636324, 9422511 +SMO Amplification Inconclusive Inconclusive 24202394, 26124204, 20215540 Zehir A et al. Nature Medicine, 2017 http://doi:10.1038/nm.4333 +SMO Q635E Likely Oncogenic Likely Gain-of-function 25759020 +SMO V414A Likely Oncogenic Likely Gain-of-function 25801792, 26619011 +SMO D473H Likely Oncogenic Likely Gain-of-function 19726788 +CARD11 C49Y Likely Oncogenic Gain-of-function 25930198, 23149938 +CARD11 S250P Oncogenic Gain-of-function 23027925, 18323416, 26776161 +CARD11 L251P Oncogenic Gain-of-function 23027925, 18323416, 26776161 +CARD11 F123I Likely Oncogenic Gain-of-function 20799731, 23149938 +CARD11 L225LI Likely Oncogenic Gain-of-function 20799731, 23149938 +CARD11 G116S Likely Oncogenic Gain-of-function 23179749 +CARD11 E127G Likely Oncogenic Gain-of-function 23179749 +CARD11 L232LI Likely Oncogenic Likely Gain-of-function 23027925 +CARD11 E93D Oncogenic Gain-of-function 23149938 +CARD11 G123S Likely Oncogenic Likely Gain-of-function 23027925 +CARD11 D387V Likely Oncogenic Likely Gain-of-function 23027925 +CARD11 Amplification Likely Oncogenic Likely Gain-of-function 18323416 Abubaker et al. Abstract# 4192, AACR 2011 http://cancerres.aacrjournals.org/content/71/8_Supplement/4192 +CARD11 E626K Likely Oncogenic Gain-of-function 26551667 +CARD11 D401N Likely Oncogenic Gain-of-function 25921526 +MEF2B K4E Oncogenic Loss-of-function 23974956, 26245647 +MEF2B N81Y Oncogenic Loss-of-function 23974956 +MEF2B E77K Oncogenic Loss-of-function 23974956 +MEF2B Y69H Oncogenic Loss-of-function 23974956 +MEF2B Amplification Likely Oncogenic Likely Gain-of-function 26245647 +MEF2B D83V Oncogenic Gain-of-function 23974956, 26245647 +CTLA4 T17A Likely Oncogenic Likely Loss-of-function 15018649, 11976786, 20064370, 10082437, 8989248, 18528295, 9459504, 12244107 +ATM V2424G Likely Oncogenic Loss-of-function 18634022, 9463314 +ATM Truncating Mutations Likely Oncogenic Likely Loss-of-function 15928302, 16832357, 16998505 +ATM E1978* Likely Oncogenic Likely Loss-of-function 21514219, 18807267 +ATM D2870A Likely Oncogenic Loss-of-function 9733515, 27304073 +ATM Deletion Likely Oncogenic Likely Loss-of-function 21993670, 16014569 +ATM N2875K Likely Oncogenic Loss-of-function 9733515, 27304073 +ATM D1853N Likely Neutral Likely Neutral 20396981, 18264724, 20799949 +NUP93 G591V Likely Neutral Neutral 26878725 +NUP93 Y629C Likely Neutral Neutral 26878725 +NUP93 Exon 13 deletion Likely Oncogenic Likely Loss-of-function 26878725 +NUP93 K442Nfs* Likely Oncogenic Likely Loss-of-function 26878725 +MAPK1 Amplification Likely Oncogenic Gain-of-function 22961667 +MAPK1 E322K Likely Oncogenic Gain-of-function 24390348, 18813840, 25320010, 26551667, 26181029, 15999996, 21098038, 16324895, 16051177 +CTNNB1 S45A Oncogenic Gain-of-function 12799363 +CTNNB1 G34A Likely Oncogenic Gain-of-function 9635572, 15829978, 9065402 +CTNNB1 G34E Likely Oncogenic Gain-of-function 9635572, 10671680, 9065402 +CTNNB1 S33Y Oncogenic Gain-of-function 9635572, 24735922, 18757411, 9065402 +CTNNB1 S37Y Likely Oncogenic Gain-of-function 20606007, 9635572, 9065402 +CTNNB1 S23R Likely Oncogenic Gain-of-function 9635572, 24735922, 18282277, 9065402 Manring et al. Abstract# 2249, AACR 2012 http://cancerres.aacrjournals.org/content/72/8_Supplement/2249 +CTNNB1 D32N Likely Oncogenic Gain-of-function 9635572, 15064718, 9065402 +CTNNB1 S37C Likely Oncogenic Gain-of-function 9635572, 9537226, 9065402 +CTNNB1 S45del Likely Oncogenic Gain-of-function 9635572, 15064718, 9065402 +CTNNB1 S33F Likely Oncogenic Likely Gain-of-function 9635572, 15829978, 27543871, 18757411, 19582367, 9065402 +CTNNB1 P44A Likely Oncogenic Gain-of-function 9635572, 18282277, 9065402 +CTNNB1 S45P Likely Oncogenic Gain-of-function 9635572, 24735922, 18282277, 9065402 Manring et al. Abstract# 2249, AACR 2012 http://cancerres.aacrjournals.org/content/72/8_Supplement/2249 +CTNNB1 S37A Likely Oncogenic Gain-of-function 15579438, 9635572, 9065402 +CTNNB1 H36P Likely Oncogenic Gain-of-function 9635572, 24735922, 18282277, 9065402 Manring et al. Abstract# 2249, AACR 2012 http://cancerres.aacrjournals.org/content/72/8_Supplement/2249 +CTNNB1 D32A Likely Oncogenic Gain-of-function 15829978 +CTNNB1 I35S Likely Oncogenic Gain-of-function 12375019, 9635572, 24735922, 18282277, 9065402, 10665646 Manring et al. Abstract# 2249, AACR 2012 http://cancerres.aacrjournals.org/content/72/8_Supplement/2249 +CTNNB1 D32G Likely Oncogenic Gain-of-function 9635572, 15064718, 9065402 +CTNNB1 S33A Oncogenic Gain-of-function 15829978 +CTNNB1 S45F Likely Oncogenic Gain-of-function 9635572, 18282277, 26686699, 9065402 +CTNNB1 S33C Oncogenic Gain-of-function 9635572, 19582367, 9065402 +CTNNB1 T41A Oncogenic Gain-of-function 9635572, 24735922, 12799363, 9065402 +CTNNB1 K335I Likely Oncogenic Gain-of-function 15579438, 9635572, 24735922, 9065402 +CTNNB1 N387K Likely Oncogenic Gain-of-function 9635572, 24735922, 9065402 +CTNNB1 D32Y Likely Oncogenic Gain-of-function 9635572, 15064718, 9065402 +CTNNB1 W383R Likely Oncogenic Gain-of-function 15579438, 9635572, 9065402 +CTNNB1 S45Y Likely Oncogenic Gain-of-function 9635572, 9065402, 9419974 +CTNNB1 S37F Likely Oncogenic Gain-of-function 9635572, 22815287, 20303878, 9537226, 9065403, 9065402 +CTNNB1 G34V Likely Oncogenic Gain-of-function 9635572, 10671680, 9671767, 9065402 +MAP2K1 F53S Likely Oncogenic Gain-of-function 17981815, 16439621 +MAP2K1 G128V Likely Oncogenic Likely Gain-of-function 24265153 +MAP2K1 L115P Likely Oncogenic Likely Gain-of-function 19915144 +MAP2K1 L37P Likely Oncogenic Likely Gain-of-function 26566875 +MAP2K1 R47Q Oncogenic Gain-of-function 24982505, 22327936 +MAP2K1 D67N Oncogenic Gain-of-function 25351745, 18060073 +MAP2K1 F129L Likely Oncogenic Gain-of-function 21705440, 19915144, 26399658 +MAP2K1 E203K Oncogenic Gain-of-function 25351745, 22197931 +MAP2K1 I103N Likely Oncogenic Gain-of-function 19915144, 12370306 +MAP2K1 P124S Oncogenic Gain-of-function 24265153, 22197931, 25370473 +MAP2K1 N382H Likely Neutral Likely Neutral 22197931 +MAP2K1 P124L Likely Oncogenic Gain-of-function 19915144, 25370473 +MAP2K1 R49L Oncogenic Gain-of-function 22327936 +MAP2K1 K57E Oncogenic Gain-of-function 26566875, 25370473, 24241536 +MAP2K1 K57T Likely Oncogenic Gain-of-function 26644315 +MAP2K1 D65N Likely Neutral Likely Neutral 26566875 +MAP2K1 Q56_V60del Oncogenic Gain-of-function 26324360 +MAP2K1 E102_I103del Likely Oncogenic Gain-of-function 25351745 +MAP2K1 Q56P Oncogenic Gain-of-function 19915144, 25351745, 22327936, 26566875 +MAP2K1 E144K Likely Oncogenic Gain-of-function 26566875 +MAP2K1 Y130C Likely Oncogenic Gain-of-function 18060073, 26566875 +MAP2K1 Amplification Inconclusive Inconclusive 26399658, 26684394 +MAP2K1 H119P Inconclusive Inconclusive 19915144 +MAP2K1 F53L Oncogenic Gain-of-function 25351745, 21383288, 22197931, 26582713, 26324360, 24241536 +MAP2K1 C121S Likely Oncogenic Gain-of-function 24448821, 25351745, 21383288 +MAP2K1 V211D Inconclusive Inconclusive 19915144, 26399658 +MAP2K1 I111A Likely Oncogenic Likely Gain-of-function 12370306 +MAP2K1 Q58_E62del Likely Oncogenic Gain-of-function 26566875 +MAP2K1 V60M Likely Oncogenic Gain-of-function 26566875 +MAP2K1 F53C Likely Oncogenic Likely Gain-of-function 17981815 +MAP2K1 I111N Inconclusive Inconclusive 19915144 +MAP2K1 I111R Likely Oncogenic Likely Gain-of-function 12370306 +MAP2K1 L115R Inconclusive Inconclusive 19915144 +MAP2K1 S218D Likely Oncogenic Gain-of-function 17981815, 16439621 +MAP2K1 S222D Oncogenic Gain-of-function 17981815, 16439621 +MAP2K1 P306H Likely Oncogenic Gain-of-function 22327936 +MAP2K1 I204T Likely Oncogenic Gain-of-function 22327936 +MAP2K1 K59del Likely Oncogenic Gain-of-function 22389471 +MAP2K1 I111P Likely Oncogenic Likely Gain-of-function 12370306 +MAP2K1 P387S Likely Neutral Likely Neutral 22389471 +MAP2K1 K57N Oncogenic Gain-of-function 25351745, 18632602, 26566875 +MAP2K1 P124Q Likely Oncogenic Gain-of-function 25370473 +MAP2K1 V60E Likely Oncogenic Likely Gain-of-function 24265153 +MAP2K1 E120Q Likely Neutral Likely Neutral 26566875 +MAP2K1 S123T Likely Oncogenic Gain-of-function 26566875 +MAP2K1 K97M Likely Neutral Loss-of-function 22177953, 10567369, 16439621 +MAP2K1 T28I Likely Oncogenic Likely Gain-of-function 26566875 +MAP2K2 Q60P Oncogenic Gain-of-function 24265154, 24055054 +MAP2K2 C125S Oncogenic Gain-of-function 24265153, 21383288 +MAP2K2 F57V Likely Oncogenic Likely Gain-of-function 18042262, 18456719, 16439621 +MAP2K2 K101M Inconclusive Inconclusive 19376813, 22177953, 16439621 +MAP2K2 V35M Oncogenic Gain-of-function 24265153, 21383288 +MAP2K2 S226D Inconclusive Inconclusive 16439621 +MAP2K2 E207K Oncogenic Gain-of-function 22197931 +MAP2K2 S222D Inconclusive Inconclusive 16439621 +MAP2K2 F57C Likely Oncogenic Gain-of-function 16439621 +MAP2K2 F57L Likely Oncogenic Likely Gain-of-function 18042262, 18456719, 16439621 +MAP2K2 N126D Oncogenic Gain-of-function 25487361, 24265153 +MAP2K2 L46F Oncogenic Gain-of-function 24265153, 21383288 +SPEN Truncating Mutations Likely Oncogenic Likely Loss-of-function 26297734 +STAG2 Truncating Mutations Likely Oncogenic Likely Loss-of-function 22417201, 21852505, 24121789, 25010205 +IL7R T244_I245insCPT Oncogenic Gain-of-function 21892159 +SOS1 R552G Likely Oncogenic Gain-of-function 17143285 +SOS1 E846K Likely Oncogenic Gain-of-function 21041952, 17143285 +SOS1 R552S Likely Oncogenic Gain-of-function 27304678 +SOS1 M269R Likely Oncogenic Gain-of-function 27304678, 17143285, 25712082, 24297905 +SOS1 G434R Likely Oncogenic Likely Gain-of-function 27304678 +SOS1 N233Y Likely Oncogenic Gain-of-function 27304678 +MYC T73A Likely Oncogenic Gain-of-function 10378696, 20399964, 21266350, 18642118, 16934487, 19029958, 10706881, 22464321 +MYC IGH-MYC Fusion Oncogenic Gain-of-function 10378696, 22333947, 16934487, 19029958, 22464321 +MYC T73I Likely Oncogenic Likely Gain-of-function 20713710, 26619011, 10825194 +MYC MYC-nick Inconclusive Inconclusive 24696454, 20691906 +MYC IGK-MYC Fusion Oncogenic Gain-of-function 19351371, 10378696, 24957271, 7731690, 8502472, 22333947, 16934487, 21887927, 19029958, 8816814, 19246886, 22464321 +MYC PVT1-MYC Fusion Likely Oncogenic Likely Gain-of-function 22134537, 24298051 +MYC Amplification Oncogenic Gain-of-function 20164920, 10378696, 16934487, 15083194, 19029958, 22464321 +MYC Fusions Likely Oncogenic Likely Gain-of-function 22333947, 16934487 +MYC IGL-MYC Fusion Oncogenic Gain-of-function 10378696, 11034608, 7731690, 8502472, 22333947, 16934487, 19029958, 8816814, 22464321 +MYCN Amplification Oncogenic Gain-of-function 12612655, 16116477, 22035742, 22139329, 23091029, 21533284, 15013217, 9214616 +MYCN P44L Likely Oncogenic Likely Gain-of-function 23334666, 24086065 +SOX9 Deletion Likely Oncogenic Likely Loss-of-function 10446171, 12783851, 9002675 +SOX9 H65Y Likely Oncogenic Loss-of-function 10446171 +SOX9 A19V Likely Neutral Neutral 10446171 +SOX9 Truncating Mutations Likely Oncogenic Likely Loss-of-function 10446171, 27248473 +SOX9 L142P Likely Oncogenic Loss-of-function 27429045 +SOX9 P70R Likely Oncogenic Likely Loss-of-function 10446171 +SOX9 F12L Likely Oncogenic Loss-of-function 10446171 +SOX9 K398A Likely Oncogenic Gain-of-function 15694126 +TET2 W1291R Likely Oncogenic Likely Loss-of-function 24315485 +TET2 D1384V Inconclusive Inconclusive 24315485 +TET2 Y1295A Likely Neutral Likely Neutral 24315485 +TET2 R1262A Likely Neutral Likely Neutral 24315485 +TET2 Y1294A Inconclusive Inconclusive 24315485 +TET2 Y1902A Likely Oncogenic Likely Loss-of-function 24315485 +TET2 N1387A Likely Oncogenic Likely Loss-of-function 24315485 +TET2 M1293A Inconclusive Inconclusive 24315485 +TET2 Truncating Mutations Likely Oncogenic Likely Loss-of-function 21057493, 24315485 +TET2 R1896M Likely Oncogenic Likely Loss-of-function 24315485 +TET2 S1290A Likely Neutral Likely Neutral 24315485 +TET2 K1299E Inconclusive Inconclusive 24315485 +TET2 H1382Y Inconclusive Inconclusive 24315485 +TET2 Deletion Likely Oncogenic Loss-of-function 21625234, 25224413, 21723200, 22017486 +TET2 S1303N Inconclusive Inconclusive 24315485 +TET2 H1904R Likely Oncogenic Likely Loss-of-function 24315485 +MYD88 L265P Oncogenic Gain-of-function 25723115, 26111727 +MYD88 M232T Oncogenic Gain-of-function 25359991 +MYD88 S243N Oncogenic Gain-of-function 24534189, 2179087 +AGO2 R583A Likely Oncogenic Likely Loss-of-function 17891150 +AGO2 Amplification Likely Oncogenic Likely Gain-of-function 18787018, 23775134 +AGO2 A603fs Likely Oncogenic Likely Loss-of-function 20198652, 14749716 +AGO2 R647A Likely Oncogenic Likely Loss-of-function 17891150 +AGO2 Q545A Likely Oncogenic Likely Loss-of-function 17891150 +AGO2 R812A Likely Oncogenic Likely Loss-of-function 17891150 +KMT2B Truncating Mutations Inconclusive Inconclusive 25998713, 16540515, 17429066 +ATR Truncating Mutations Likely Oncogenic Likely Loss-of-function 10691732, 15282542 +ATRX Truncating Mutations Likely Oncogenic Likely Loss-of-function 21719641, 8968741, 24148618, 15591283, 14592816, 18409179, 17609377 +ATRX Deletion Likely Oncogenic Likely Loss-of-function 21719641, 27311324, 24148618, 26741321, 23904111 +CDK12 R882L Likely Oncogenic Loss-of-function 24554720, 21720365, 25712099 +CDK12 Amplification Inconclusive Inconclusive 20932292, 26658019, 21097718 +CDK12 K765R Likely Oncogenic Likely Loss-of-function 24554720, 25712099 +CDK12 Truncating Mutations Likely Oncogenic Likely Loss-of-function 24554720, 21720365, 25712099, 26787825 +CDK12 W719* Likely Oncogenic Loss-of-function 24554720, 25712099 +CDK12 L996F Likely Oncogenic Loss-of-function 24554720, 21720365, 25712099 +CDK12 Deletion Likely Oncogenic Likely Loss-of-function 24554720, 25712099, 24240700 +CDK12 Y901C Likely Oncogenic Loss-of-function 24554720, 21720365, 25712099 +CDK12 G909R Likely Oncogenic Loss-of-function 24554720, 25712099 +CDK12 D887N Likely Oncogenic Likely Loss-of-function 24554720 +CDK12 K975E Likely Neutral Likely Neutral 24554720, 21720365, 25712099 +AXL Amplification Likely Oncogenic Likely Gain-of-function 23264849, 22751098, 25337673, 25966280 +MYOD1 L122R Oncogenic Likely Gain-of-function 24793135, 1329087 +B2M M1R Likely Oncogenic Loss-of-function 22137796 +B2M M1V Likely Oncogenic Loss-of-function 24947018 +B2M M1T Likely Oncogenic Loss-of-function 22137796 +B2M Deletion Likely Oncogenic Likely Loss-of-function 25594174, 25294904, 22833104, 16730261, 22137796, 23784959, 9637706, 1898655 +B2M M1K Likely Oncogenic Loss-of-function 24947018, 22137796 +B2M M1I Likely Oncogenic Loss-of-function 11894933, 24947018 +B2M Truncating Mutations Likely Oncogenic Likely Loss-of-function 25594174, 25294904, 22833104, 16730261, 22137796, 23784959, 9637706, 1898655 +SRC Amplification Likely Oncogenic Likely Gain-of-function 24788409, 11114744, 15060621, 22589274 Zehir A et al. Nature Medicine, 2017 http://doi:10.1038/nm.4333 +SRC Q531* Likely Oncogenic Gain-of-function 9988270 +GATA3 Amplification Likely Oncogenic Likely Gain-of-function 20154722, 11441075, 18471881, 16087702, 24448324, 20855495, 21779441 +GATA3 R177Pfs*126 Likely Oncogenic Loss-of-function 26268891 +GATA3 Deletion Likely Oncogenic Likely Loss-of-function 10935639, 15361840, 23426732, 26637396, 24758297, 7829479 +GATA3 Truncating Mutations Likely Oncogenic Likely Loss-of-function 23426732, 18242514, 26637396, 27588951, 24758297 +BARD1 Truncating Mutations Likely Oncogenic Likely Loss-of-function +BARD1 Deletion Likely Oncogenic Likely Loss-of-function 20029420, 17848578, 20842729 +CCND1 256_286trunc Likely Oncogenic Gain-of-function 17299095, 9832503, 16732330, 9926916 +CCND1 C47S Likely Oncogenic Gain-of-function 24145436, 27713153 +CCND1 Y44D Likely Oncogenic Gain-of-function 24145436, 27713153 +CCND1 L283_D294del Likely Oncogenic Likely Gain-of-function 9832503, 16732330 +CCND1 T286A Oncogenic Gain-of-function 16732330, 11124803 +CCND1 D289del Oncogenic Gain-of-function 9832503, 16732330 +CCND1 P287S Likely Oncogenic Likely Gain-of-function 16732330, 12955092, 12615961 +CCND1 CCND1-IGH Fusion Likely Oncogenic Gain-of-function 14514791, 25596256, 16690963, 16402392 +CCND1 P287T Oncogenic Gain-of-function 9832503, 16732330, 12955092 +CCND1 P287A Likely Oncogenic Gain-of-function 16732330, 12615961 +CCND1 Amplification Oncogenic Gain-of-function 9832503, 20164920, 20074063, 8114739, 10508165, 11486031, 16393691, 9792703, 19020303, 21734724 +CCND1 Truncating Mutations Likely Oncogenic Likely Gain-of-function 28483394, 19823025 +CCND1 D289_D292del Likely Oncogenic Likely Gain-of-function 9832503, 16732330 +CCND1 T286I Oncogenic Gain-of-function 9832503, 16732330, 11124803 +BCL2 IGH-BCL2 Fusion Oncogenic Gain-of-function 23939148, 3500184, 18202696, 3874430, 10910891, 2875799, 23892979 +KEAP1 G480W Likely Oncogenic Likely Loss-of-function 24322982 +KEAP1 R272C Oncogenic Loss-of-function 18316592 +KEAP1 D422N Oncogenic Loss-of-function 24322982 +KEAP1 C23Y Likely Oncogenic Loss-of-function 17822677 +KEAP1 R470C Oncogenic Loss-of-function 24322982 +KEAP1 Deletion Likely Oncogenic Likely Loss-of-function 17020408, 24142871 +KEAP1 Truncating Mutations Likely Oncogenic Likely Loss-of-function 17020408, 24142871, 24322982 +KEAP1 G430C Oncogenic Loss-of-function 18316592 +KEAP1 R415G Oncogenic Loss-of-function 18316592 +KEAP1 R320Q Oncogenic Loss-of-function 24322982 +KEAP1 S243C Oncogenic Loss-of-function 24322982 +KEAP1 V155F Oncogenic Loss-of-function 24322982 +KEAP1 G333S Oncogenic Loss-of-function 23912815 +KEAP1 G423V Oncogenic Loss-of-function 24322982 +KEAP1 G333C Oncogenic Loss-of-function 19818716 +KEAP1 G186R Oncogenic Loss-of-function 24322982 +PTCH1 Truncating Mutations Likely Oncogenic Likely Loss-of-function 8782823 +PTCH1 R571W Likely Neutral Likely Neutral 24368541 +PTEN A126V Oncogenic Loss-of-function 21828076 +PTEN M199del Oncogenic Loss-of-function 11051241 +PTEN G129A Likely Oncogenic Likely Loss-of-function 21828076, 26619011 +PTEN G127N Oncogenic Loss-of-function 21828076 +PTEN G165R Likely Oncogenic Loss-of-function 10866302 +PTEN R173H Oncogenic Loss-of-function 10866302, 24721394 +PTEN G127E Oncogenic Loss-of-function 21828076 +PTEN S170R Oncogenic Loss-of-function 9467011, 10866302 +PTEN G165V Oncogenic Loss-of-function 9467011, 21828076 +PTEN H93Q Oncogenic Loss-of-function 21828076 +PTEN F154L Oncogenic Loss-of-function 19329485 +PTEN D92G Oncogenic Loss-of-function 21828076 +PTEN R130A Oncogenic Loss-of-function 21828076 +PTEN L108P Likely Oncogenic Loss-of-function 25527629 +PTEN A34D Oncogenic Loss-of-function 21828076 +PTEN A126G Oncogenic Loss-of-function 21828076 +PTEN K125E Oncogenic Loss-of-function 20926450, 21828076 +PTEN M35R Oncogenic Loss-of-function 21828076 +PTEN D162G Oncogenic Loss-of-function 21828076 +PTEN K125R Likely Neutral Neutral 21828076 +PTEN D24N Likely Oncogenic Likely Loss-of-function 17213812 +PTEN L112R Oncogenic Loss-of-function 10866302 +PTEN K125L Oncogenic Loss-of-function 21828076 +PTEN H123Q Oncogenic Loss-of-function 21828076 +PTEN I122L Oncogenic Loss-of-function 21828076 +PTEN R335L Oncogenic Loss-of-function 21828076 +PTEN C124R Oncogenic Loss-of-function 9467011, 21828076, 10866302 +PTEN R130* Oncogenic Loss-of-function 24721394 +PTEN T401I Likely Oncogenic Loss-of-function 10866302 +PTEN H93R Oncogenic Loss-of-function 21828076 +PTEN T319del Oncogenic Loss-of-function 10468583 +PTEN F341V Oncogenic Loss-of-function 11051241, 10866302 +PTEN C105F Likely Oncogenic Loss-of-function 10866302 +PTEN G251C Likely Oncogenic Loss-of-function 10866302 +PTEN S227F Likely Oncogenic Loss-of-function 10866302 +PTEN D92N Likely Oncogenic Loss-of-function 21828076 +PTEN L23F Oncogenic Loss-of-function 17213812 +PTEN R159G Likely Oncogenic Loss-of-function 17942903 +PTEN T131L Oncogenic Loss-of-function 21828076 +PTEN F347L Oncogenic Loss-of-function 10866302 +PTEN K342N Likely Oncogenic Loss-of-function 10866302 +PTEN I122V Likely Neutral Neutral 21828076 +PTEN A39P Oncogenic Loss-of-function 25527629 +PTEN G20E Likely Oncogenic Loss-of-function 17213812, 10866302 +PTEN L112P Oncogenic Loss-of-function 25527629, 10866302 +PTEN Y65C Oncogenic Loss-of-function 20926450, 19457929 +PTEN D24Y Oncogenic Loss-of-function 17213812 +PTEN L345Q Likely Oncogenic Loss-of-function 10866302 +PTEN Y27S Likely Oncogenic Loss-of-function 10866302 +PTEN A126S Oncogenic Loss-of-function 21828076 +PTEN V217D Oncogenic Loss-of-function 21828076 +PTEN R15S Oncogenic Gain-of-function 17213812 +PTEN R335* Oncogenic Loss-of-function 23475934 +PTEN R15K Oncogenic Loss-of-function 21828076 +PTEN P96Q Oncogenic Loss-of-function 21828076 +PTEN M134L Likely Oncogenic Loss-of-function 10866302 +PTEN G129R Oncogenic Loss-of-function 21828076, 25527629, 10866302, 9811831 +PTEN D92H Oncogenic Loss-of-function 21828076 +PTEN R130G Oncogenic Loss-of-function 21828076, 25527629, 11051241, 10866302, 9811831 +PTEN H93Y Oncogenic Loss-of-function 21828076, 10866302 +PTEN C124S Likely Oncogenic Loss-of-function 25527629, 9811831 +PTEN D92V Oncogenic Loss-of-function 21828076 +PTEN D162H Oncogenic Loss-of-function 23840064 +PTEN G129E Oncogenic Loss-of-function 9467011, 21828076, 25527629, 10866302, 9811831 +PTEN K62R Oncogenic Loss-of-function 20926450, 19457929 +PTEN R161G Oncogenic Loss-of-function 21828076 +PTEN T167A Oncogenic Loss-of-function 21828076 +PTEN D252G Oncogenic Loss-of-function 25527629 +PTEN A121V Likely Neutral Neutral 21828076 +PTEN A121P Likely Oncogenic Loss-of-function 10866302 +PTEN R130K Oncogenic Loss-of-function 21828076 +PTEN F241S Oncogenic Loss-of-function 21828076, 25527629 +PTEN K125M Oncogenic Loss-of-function 21828076 +PTEN H61R Likely Oncogenic Loss-of-function 10866302 +PTEN Y68H Likely Oncogenic Loss-of-function 23840064, 9467011, 10866302 +PTEN G36R Oncogenic Loss-of-function 21828076 +PTEN Y68D Oncogenic Loss-of-function 21828076 +PTEN F21A Likely Oncogenic Loss-of-function 17213812 +PTEN H123D Oncogenic Loss-of-function 21828076 +PTEN I32del Likely Oncogenic Loss-of-function 24904117, 10560660, 22817889, 9326929, 24293293 +PTEN V343L Oncogenic Loss-of-function 21828076 +PTEN S362L Likely Neutral Likely Neutral 19329485 +PTEN T131S Likely Neutral Neutral 21828076 +PTEN D331G Likely Oncogenic Loss-of-function 10866302 +PTEN E157G Oncogenic Loss-of-function 21828076 +PTEN N94I Oncogenic Loss-of-function 21828076 +PTEN V343E Oncogenic Loss-of-function 10866302 +PTEN Y155C Oncogenic Loss-of-function 21828076, 11051241, 10866302 +PTEN H61D Oncogenic Loss-of-function 21828076 +PTEN N48K Oncogenic Loss-of-function 21828076, 25527629 +PTEN V133I Likely Oncogenic Loss-of-function 10866302 +PTEN C136R Likely Oncogenic Loss-of-function 23475934 +PTEN G165E Oncogenic Loss-of-function 21828076 +PTEN Q110R Likely Neutral Likely Neutral 19329485 +PTEN R130Q Likely Oncogenic Loss-of-function 10866302 +PTEN G129D Oncogenic Loss-of-function 21828076 +PTEN A121E Oncogenic Loss-of-function 21828076 +PTEN Truncating Mutations Likely Oncogenic Likely Loss-of-function 17218262, 11237521 +PTEN S10N Likely Oncogenic Loss-of-function 10866302 +PTEN N276S Likely Oncogenic Loss-of-function 25527629 +PTEN A126D Oncogenic Loss-of-function 21828076 +PTEN I122S Oncogenic Loss-of-function 21828076 +PTEN K289E Likely Oncogenic Loss-of-function 10866302 +PTEN I168F Oncogenic Loss-of-function 21828076 +PTEN D92E Oncogenic Loss-of-function 21828076 +PTEN R173P Likely Oncogenic Loss-of-function 10866302 +PTEN T160I Oncogenic Loss-of-function 21828076 +PTEN Y174N Likely Oncogenic Loss-of-function 10866302 +PTEN I33del Likely Oncogenic Loss-of-function 24904117, 10560660, 22817889, 9326929, 24293293 +PTEN S170N Likely Oncogenic Loss-of-function 10866302 +PTEN H118P Oncogenic Loss-of-function 21828076, 25527629 +PTEN K128R Oncogenic Loss-of-function 21828076 +PTEN D107Y Likely Oncogenic Loss-of-function 10866302 +PTEN P95L Oncogenic Loss-of-function 21828076 +PTEN C136Y Oncogenic Loss-of-function 10866302 +PTEN L325F Oncogenic Loss-of-function 19329485 +PTEN G44D Oncogenic Loss-of-function 21828076 +PTEN K128N Oncogenic Loss-of-function 21828076 +PTEN K128Q Oncogenic Loss-of-function 25447541 +PTEN D92A Oncogenic Loss-of-function 21828076 +PTEN P169H Oncogenic Loss-of-function 21828076 +PTEN H123Y Oncogenic Loss-of-function 21828076 +PTEN V369G Likely Neutral Neutral 21828076, 10866302 +PTEN Y16C Likely Oncogenic Loss-of-function 10866302 +PTEN D326N Oncogenic Loss-of-function 21828076, 25527629 +PTEN T319A Likely Oncogenic Likely Loss-of-function 26166433 +PTEN R173C Likely Oncogenic Loss-of-function 10866302 +PTEN L42R Likely Oncogenic Loss-of-function 10866302 +PTEN Deletion Oncogenic Loss-of-function 12844284, 9697695, 12370746, 21430697 +PTEN C124N Oncogenic Loss-of-function 21828076 +PTEN H93D Oncogenic Loss-of-function 21828076 +PTEN K128T Oncogenic Loss-of-function 21828076 +PTEN D301N Likely Neutral Likely Neutral 19329485 +PTEN P95S Oncogenic Loss-of-function 19329485 +PTEN T131A Oncogenic Loss-of-function 21828076 +PTEN L181P Oncogenic Loss-of-function 21828076 +PTEN T131I Oncogenic Loss-of-function 21828076 +PTEN P38L Likely Oncogenic Likely Loss-of-function 23039341 +PTEN C71Y Oncogenic Loss-of-function 11051241, 10866302 +PTEN R130L Oncogenic Loss-of-function 9467011, 25527629, 10866302 +BCOR Deletion Likely Oncogenic Likely Loss-of-function 26847029, 10582652, 2212066 +BCOR BCOR-CCNB3 Fusion Oncogenic Likely Switch-of-function 22387997 +BCOR BCOR-RARA Fusion Oncogenic Likely Switch-of-function 20807888 +BCOR ZC3H7B-BCOR Fusion Oncogenic Likely Switch-of-function 23580382 +BCOR Truncating Mutations Likely Oncogenic Likely Loss-of-function 26847029, 25550361, 22237022, 22012066, 24047651 +BCOR Fusions Likely Oncogenic Likely Switch-of-function 24515802 +RNF43 Truncating Mutations Likely Oncogenic Likely Loss-of-function 23847203, 23096461, 25344691 +CIC Fusions Likely Oncogenic Likely Loss-of-function 22072439, 25007147, 28188754 +CIC R201W Likely Oncogenic Likely Loss-of-function 22072542, 25193860 +CIC R1515H Likely Oncogenic Likely Loss-of-function 22072542, 25193860 +CIC Truncating Mutations Likely Oncogenic Likely Loss-of-function 22072542, 22588899, 21817013, 24117486, 24086756 +CIC CIC-DUX4 Fusion Oncogenic Switch-of-function 22072439, 16717057 +INPP4B Deletion Likely Oncogenic Likely Loss-of-function 25883023, 25428846, 19647222, 21127264 +INPP4B Truncating Mutations Likely Oncogenic Likely Loss-of-function 25428846, 19647222, 21127264 +STAT3 F384V Likely Oncogenic Likely Gain-of-function 22751495, 17881745, 17676033, 18602572, 26619011 +STAT3 D661Y Likely Oncogenic Gain-of-function 25586472 +STAT3 F384Y Likely Oncogenic Likely Gain-of-function 22751495, 17881745, 17676033, 18602572, 26619011 +STAT3 Y640F Oncogenic Gain-of-function 25586472, 25873174, 22591296 +STAT3 F384L Likely Oncogenic Likely Gain-of-function 22751495, 17881745, 17676033, 18602572, 26619011 +STAT3 S614R Likely Oncogenic Gain-of-function 25586472, 25709890 +STAT3 D661V Likely Oncogenic Gain-of-function 22591296 +STAT3 H410R Likely Oncogenic Gain-of-function 26419508 +WHSC1L1 Amplification Inconclusive Inconclusive 18757432, 24874471, 21664949 +PRDM1 P48R Likely Oncogenic Loss-of-function 21156281 +PRDM1 C569Y Likely Oncogenic Loss-of-function 21156281 +PRDM1 Truncating Mutations Likely Oncogenic Likely Loss-of-function 20651244, 27568520, 16424392, 21156281, 16492805 +PRDM1 Y149D Likely Oncogenic Loss-of-function 21156281 +PRDM1 P48T Likely Oncogenic Loss-of-function 21156281 +PRDM1 Deletion Likely Oncogenic Likely Loss-of-function 27568520, 16424392, 21156281, 16492805 +JAK1 V658F Oncogenic Gain-of-function 20868368, 19139102, 21393331 +JAK1 A634D Oncogenic Gain-of-function 19139102 +JAK1 L783F Oncogenic Gain-of-function 21393331 +JAK1 F958S Oncogenic Gain-of-function 21393331 +JAK1 R724H Oncogenic Gain-of-function 18362171 +JAK1 S729C Oncogenic Gain-of-function 23788652 +JAK1 K1026E Oncogenic Gain-of-function 20868368 +JAK1 S703I Oncogenic Gain-of-function 24825865, 23788652 +JAK1 F958C Oncogenic Gain-of-function 21393331 +JAK1 A723D Likely Oncogenic Gain-of-function 24735922 +JAK1 Truncating Mutations Likely Oncogenic Likely Loss-of-function 24154688 +JAK1 Y1035C Oncogenic Gain-of-function 20868368 +JAK1 G871E Likely Oncogenic Likely Loss-of-function 16474838 +JAK1 Y652H Likely Oncogenic Gain-of-function 21551237 +JAK1 R879C Oncogenic Gain-of-function 18362171 +JAK1 G1079D Likely Oncogenic Gain-of-function 25873174 +JAK1 K648N Likely Oncogenic Gain-of-function 21551237 +JAK1 L910P Oncogenic Gain-of-function 20868368, 25873174, 23788652 +JAK1 F958V Oncogenic Gain-of-function 21393331 +JAK1 S646F Oncogenic Gain-of-function 19470474 +JAK2 V617F Oncogenic Gain-of-function 12351625, 15793561, 21533163, 19543316 +JAK2 R277K Inconclusive Inconclusive 26419724 +JAK2 Y931C Inconclusive Inconclusive 26419724 +JAK2 K539L Oncogenic Gain-of-function 20585391, 17267906, 21362419 +JAK2 C618R Oncogenic Gain-of-function 22960131 +JAK2 SPAG9-JAK2 Fusion Likely Oncogenic Likely Gain-of-function 25515960, 25951811 +JAK2 I1018W Inconclusive Inconclusive 26419724 +JAK2 G417P Inconclusive Inconclusive 26419724 +JAK2 TEL-JAK2 Fusion Oncogenic Gain-of-function 22733019, 10706877, 9360930, 15676212, 10845925 +JAK2 Fusions Likely Oncogenic Likely Gain-of-function 25207766, 24913195 +JAK2 S1025C Inconclusive Inconclusive 26419724 +JAK2 PAX5-JAK2 Fusion Oncogenic Gain-of-function 25207766, 25515960 +JAK2 Amplification Oncogenic Gain-of-function 20628145 +JAK2 S1039F Inconclusive Inconclusive 26419724 +JAK2 R683K Oncogenic Gain-of-function 18805579, 23748007, 23452118 +JAK2 W1038C Inconclusive Inconclusive 26419724 +JAK2 ATF7IP-JAK2 Fusion Oncogenic Gain-of-function 25207766 +JAK2 N542_E543del Oncogenic Gain-of-function 17267906 +JAK2 R683G Oncogenic Gain-of-function 18805579, 20585391, 23748007, 23452118 +JAK2 D544H Inconclusive Inconclusive 26419724 +JAK2 L1026F Inconclusive Inconclusive 26419724 +JAK2 Y1045* Inconclusive Inconclusive 26419724 +JAK2 I1018F Inconclusive Inconclusive 26419724 +JAK2 F1061W Inconclusive Inconclusive 26419724 +JAK2 F537_K539delinsL Oncogenic Gain-of-function 17267906 +JAK2 BCR-JAK2 Fusion Oncogenic Gain-of-function 25664618, 22549126, 22384256, 25789185, 23904814, 18537978, 16001431, 24913195, 18503828 +JAK2 SSBP2-JAK2 Fusion Likely Oncogenic Likely Gain-of-function 21325169, 18618714 +JAK2 L611V Likely Oncogenic Likely Gain-of-function 20182460 +JAK2 L551P Inconclusive Inconclusive 26419724 +JAK2 H538Q Oncogenic Gain-of-function 17267906 +JAK2 R683T Inconclusive Inconclusive 26419724 +JAK2 V1075F Inconclusive Inconclusive 26419724 +JAK2 R683S Oncogenic Gain-of-function 18805579, 23748007, 23452118 +JAK2 Y1045W Inconclusive Inconclusive 26419724 +JAK2 L983F Inconclusive Inconclusive 26419724 +JAK2 PCM1-JAK2 Fusion Likely Oncogenic Gain-of-function 16034466, 21325169, 23372669, 15805263, 16424865, 24913195 +JAK2 T875N Oncogenic Gain-of-function 20585391, 16804112, 19543316, 21362419 +AURKA F31I Likely Oncogenic Gain-of-function 12881723, 12208850 +AURKA K162D Likely Neutral Loss-of-function 12237287, 25395580 +AURKA Amplification Oncogenic Gain-of-function 9606188, 9771714, 10914715 +STK11 Deletion Likely Oncogenic Likely Loss-of-function 16582077, 21532627, 1627113, 19892943 +STK11 K78I Likely Oncogenic Loss-of-function 9837816 +STK11 W308C Likely Oncogenic Loss-of-function 9837816, 15987703 +STK11 Truncating Mutations Likely Oncogenic Likely Loss-of-function 24652667, 21516316, 19340305, 19892943, 25079552 +STK11 H174R Likely Oncogenic Loss-of-function 25960268 +STK11 D194Y Likely Oncogenic Loss-of-function 26917230 +STK11 F354L Likely Neutral Likely Neutral 15800014, 10676634 +STK11 G163D Likely Oncogenic Loss-of-function 9887330, 14668798, 10430928, 9605748 +STK11 R304W Oncogenic Loss-of-function 9837816, 12552571 +STK11 K78A Likely Oncogenic Loss-of-function 15800014, 14668798 +STK11 A205T Oncogenic Loss-of-function 16407837 +STK11 M136R Likely Oncogenic Loss-of-function 14668798 +STK11 D176N Likely Oncogenic Loss-of-function 9837816, 15987703 +STK11 I177N Oncogenic Loss-of-function 12552571 +STK11 L67P Likely Oncogenic Loss-of-function 9837816, 15987703 +JUN Amplification Oncogenic Gain-of-function 19449367, 17418412 +PTPN11 Q79R Likely Oncogenic Likely Gain-of-function 15834506 +PTPN11 E76K Oncogenic Gain-of-function 15834506, 12717436 +PTPN11 Y62C Likely Oncogenic Gain-of-function 15604238 +PTPN11 G464A Inconclusive Inconclusive 24935154 +PTPN11 P491S Likely Oncogenic Likely Gain-of-function 24891296 +PTPN11 D106A Oncogenic Gain-of-function 18286234 +PTPN11 E76A Oncogenic Gain-of-function 15834506, 12717436 +PTPN11 R498L Inconclusive Inconclusive 24935154 +PTPN11 K590R Likely Neutral Likely Switch-of-function 25823821 +PTPN11 A72V Oncogenic Gain-of-function 15834506 +PTPN11 R498W Likely Oncogenic Likely Loss-of-function 17053061, 24891296 +PTPN11 Deletion Oncogenic Loss-of-function 22869052 +PTPN11 Q510E Likely Oncogenic Likely Loss-of-function 25359717, 21803945, 22058153 +PTPN11 T73I Oncogenic Gain-of-function 15834506 +PTPN11 E139D Likely Oncogenic Likely Gain-of-function 16358218 +PTPN11 V45L Likely Oncogenic Gain-of-function 15604238 +PTPN11 Y63C Likely Oncogenic Gain-of-function 15834506 +PTPN11 I282V Oncogenic Gain-of-function 14974085, 15834506 +PTPN11 T507K Oncogenic Gain-of-function 15604238, 18286234 +PTPN11 E69K Likely Oncogenic Likely Gain-of-function 15604238, 12717436 +PTPN11 D61Y Oncogenic Gain-of-function 15834506, 12717436 +PTPN11 F71I Oncogenic Gain-of-function 15834506 +PTPN11 D61N Oncogenic Gain-of-function 15834506 +PTPN11 A72S Oncogenic Gain-of-function 14974085 +PTPN11 G503V Likely Oncogenic Likely Gain-of-function 15834506 +PTPN11 M504V Oncogenic Gain-of-function 15834506 +PTPN11 T468M Oncogenic Loss-of-function 26742426, 16358218, 25288766 +PTPN11 S502T Likely Oncogenic Gain-of-function 15834506 +PTPN11 N308D Oncogenic Gain-of-function 14974085, 15834506, 12717436 +NF1 R1391S Likely Oncogenic Loss-of-function 8052307, 19573811, 24576830, 9003501, 12509763, 8563751, 7542586 +NF1 Truncating Mutations Likely Oncogenic Likely Loss-of-function 8052307, 26345759, 19573811, 8563751, 23913538, 7542586, 7655472, 10862084, 24576830, 23047742, 10543400, 12509763, 14722914 +NF1 R1276Q Likely Oncogenic Loss-of-function 8052307, 19573811, 24576830, 12509763, 8563751, 22807134, 7542586 +NF1 S1463F Likely Oncogenic Loss-of-function 8052307, 19573811, 24576830, 12509763, 8563751, 22807134, 7542586, 22108604 +NF1 E1356G Likely Oncogenic Loss-of-function 8052307, 19573811, 24576830, 12509763, 8563751, 22807134, 7542586 +NF1 T1324N Likely Oncogenic Loss-of-function 8052307, 19573811, 24576830, 12509763, 8563751, 22807134, 7542586 +NF1 Deletion Likely Oncogenic Loss-of-function 23460398, 8052307, 19573811, 24576830, 12509763, 8563751, 19767589, 7542586, 20513137 +NF1 L1301R Likely Oncogenic Loss-of-function 8052307, 19573811, 24576830, 12509763, 8563751, 22807134, 7542586 +NF1 K1436Q Likely Oncogenic Loss-of-function 8052307, 19573811, 24576830, 12509763, 8563751, 22807134, 7542586 +NF1 R1276P Oncogenic Loss-of-function 9302992, 9219684, 9668168 +NF1 Y489C Oncogenic Loss-of-function 11258625 +NF1 K1423E Oncogenic Loss-of-function 8052307, 19573811, 24576830, 12509763, 8563751, 1568247, 7542586 +NF1 R2450* Likely Oncogenic Likely Loss-of-function 23288408 +NF1 V1398D Likely Oncogenic Loss-of-function 8052307, 19573811, 24576830, 12509763, 8563751, 22807134, 7542586 +NF1 R1204W Likely Oncogenic Loss-of-function 8052307, 19573811, 24576830, 12509763, 8563751, 22807134, 7542586 +NF1 R1391G Likely Oncogenic Loss-of-function 8052307, 19573811, 24576830, 12509763, 8563751, 22807134, 7542586 +NF1 R1204G Likely Oncogenic Loss-of-function 8052307, 19573811, 24576830, 12509763, 8563751, 22807134, 7542586 +FOXL2 Amplification Inconclusive Inconclusive 21623383 +FOXL2 C134W Likely Oncogenic Loss-of-function 24342437, 24817949, 23372819 +PTPRD Deletion Oncogenic Loss-of-function 19478061, 19074898, 26267899 +PTPRD G446E Likely Oncogenic Likely Loss-of-function 19074898, 25113440, 8393854 +PTPRD P1311T Likely Oncogenic Likely Loss-of-function 19478061, 26267899 +PTPRD Truncating Mutations Likely Oncogenic Likely Loss-of-function 19478061, 25113440 +PTPRD V1565I Likely Oncogenic Likely Loss-of-function 19074898 +PTPRD R1088C Likely Oncogenic Likely Loss-of-function 19478061 +BRCA1 E1682K Likely Neutral Likely Neutral 20516115 +BRCA1 C44F Likely Oncogenic Loss-of-function 20103620, 22034435, 23161852, 16403807 +BRCA1 E1282V Likely Neutral Likely Neutral 23867111 +BRCA1 S1715C Likely Oncogenic Likely Loss-of-function 20516115 +BRCA1 K56N Inconclusive Inconclusive 22034435, 16403807 +BRCA1 V1810G Likely Oncogenic Likely Loss-of-function 15004537, 15172985, 20516115 +BRCA1 R1589P Likely Neutral Likely Neutral 23867111 +BRCA1 I124V Inconclusive Inconclusive 23161852 +BRCA1 A1843T Likely Oncogenic Likely Loss-of-function 15172985, 11573086, 12496477 +BRCA1 H1746Q Inconclusive Inconclusive 23867111 +BRCA1 G1770V Likely Oncogenic Loss-of-function 23867111, 23613828 +BRCA1 I1766S Likely Oncogenic Loss-of-function 18680205, 20516115, 17308087 +BRCA1 Q1756fs Oncogenic Loss-of-function 14729053, 23867111, 27454287, 15569676, 9145676, 14576434 +BRCA1 I68K Inconclusive Inconclusive 22034435, 16403807 +BRCA1 E1250K Likely Neutral Likely Neutral 23867111 +BRCA1 W1718C Likely Oncogenic Loss-of-function 15172985, 23867111, 9799248, 20516115 +BRCA1 L1780P Likely Oncogenic Loss-of-function 15172985, 10811118, 20516115 +BRCA1 M1775R Oncogenic Loss-of-function 15004537, 14729053, 10811118, 12427738, 7545954, 8751436, 16101277, 11573086, 15689452, 15569676, 8942979, 10635334, 23161852, 15133502, 7939630, 15172985, 20516115, 21922593, 9159158 +BRCA1 G1788V Likely Oncogenic Loss-of-function 15004537, 15172985, 9796975, 15689452, 20516115 +BRCA1 L1267S Likely Neutral Likely Neutral 23867111 +BRCA1 S1651F Likely Neutral Neutral 23867111, 20516115 +BRCA1 R841Q Likely Neutral Likely Neutral 23867111 +BRCA1 S1101N Likely Neutral Likely Neutral 23867111 +BRCA1 E1836K Likely Oncogenic Likely Loss-of-function 20516115 +BRCA1 I90T Inconclusive Inconclusive 23161852 +BRCA1 F1662S Likely Neutral Likely Neutral 20516115 +BRCA1 S1164I Likely Oncogenic Likely Loss-of-function 18680205 +BRCA1 I42V Likely Neutral Neutral 20103620, 23161852 +BRCA1 A1752V Likely Oncogenic Likely Loss-of-function 20516115 +BRCA1 E33A Likely Oncogenic Likely Loss-of-function 21922593 +BRCA1 D1778Y Likely Neutral Likely Neutral 20516115 +BRCA1 P1856S Likely Neutral Likely Neutral 20516115 +BRCA1 A1830T Likely Neutral Likely Neutral 20516115 +BRCA1 C1697R Likely Oncogenic Loss-of-function 15172985, 20516115, 11157798 +BRCA1 K45T Inconclusive Inconclusive 22034435, 16403807 +BRCA1 T1720A Likely Neutral Likely Neutral 15004537, 15172985, 23867111, 15689452, 20516115 +BRCA1 N1819Y Inconclusive Inconclusive 15004537 +BRCA1 E1644G Likely Neutral Likely Neutral 17308087 +BRCA1 H1686Q Likely Oncogenic Loss-of-function 15172985, 23867111, 12496477 +BRCA1 P1637L Likely Neutral Likely Neutral 9159158 +BRCA1 F1761I Likely Oncogenic Likely Loss-of-function 15172985, 10811118 +BRCA1 P798L Likely Neutral Likely Neutral 23867111 +BRCA1 S153R Likely Neutral Neutral 23161852 +BRCA1 E143K Likely Neutral Likely Neutral 23161852 +BRCA1 W1837R Likely Oncogenic Loss-of-function 15172985, 23867111, 9799248, 8968102, 15689452, 20516115 +BRCA1 M1652K Likely Oncogenic Likely Loss-of-function 15004537, 15172985, 10811118 +BRCA1 R1699W Oncogenic Loss-of-function 15172985, 23867111, 11573086, 12496476, 20516115, 11157798, 7939630 +BRCA1 V1378I Likely Neutral Likely Neutral 23867111 +BRCA1 V1838E Likely Oncogenic Likely Loss-of-function 20516115 +BRCA1 H1421Y Likely Neutral Likely Neutral 15689452 +BRCA1 Y179C Inconclusive Inconclusive 18680205, 23161852 +BRCA1 P1806A Likely Neutral Likely Neutral 15004537, 15172985, 10811118, 20516115, 17308087 +BRCA1 P1776S Inconclusive Inconclusive 15172985, 10196379 +BRCA1 S59R Inconclusive Inconclusive 22034435, 16403807 +BRCA1 P1614S Likely Neutral Likely Neutral 17308087 +BRCA1 I89T Inconclusive Inconclusive 22034435, 16403807 +BRCA1 C39Y Oncogenic Loss-of-function 20103620, 22034435, 23161852, 21922593, 16403807 +BRCA1 L1854P Likely Oncogenic Likely Loss-of-function 20516115 +BRCA1 W1837C Likely Oncogenic Likely Loss-of-function 20516115 +BRCA1 T1773I Likely Oncogenic Likely Loss-of-function 20516115 +BRCA1 R1589H Likely Neutral Likely Neutral 23613828 +BRCA1 K45Q Likely Neutral Likely Neutral 23867111 +BRCA1 E60L Inconclusive Inconclusive 22034435, 16403807 +BRCA1 L1407P Likely Oncogenic Likely Loss-of-function 23867111, 19369211, 15689452, 16793542, 15770685 +BRCA1 S1715R Likely Oncogenic Loss-of-function 15172985, 20516115, 11157798 +BRCA1 S1841N Likely Oncogenic Likely Loss-of-function 15172985, 9799248, 20516115 +BRCA1 S1301R Likely Neutral Likely Neutral 23867111 +BRCA1 E29V Inconclusive Inconclusive 22034435, 16403807 +BRCA1 V1736G Likely Oncogenic Likely Loss-of-function 20516115 +BRCA1 I31M Likely Neutral Neutral 20103620, 23161852, 16403807 +BRCA1 T37R Likely Oncogenic Loss-of-function 20103620, 22034435, 23161852, 16403807 +BRCA1 P1856T Inconclusive Inconclusive 15172985 +BRCA1 C64G Likely Oncogenic Loss-of-function 20103620, 23867111, 22034435, 10635334, 23161852, 16403807 +BRCA1 R71G Inconclusive Inconclusive 20103620, 11385711, 23161852 +BRCA1 K50L Inconclusive Inconclusive 22034435, 16403807 +BRCA1 G1706A Likely Neutral Neutral 15172985, 23867111, 15689452, 15923272, 20516115 +BRCA1 K1702E Likely Oncogenic Likely Loss-of-function 15172985, 10811118 +BRCA1 R496C Likely Neutral Likely Neutral 18036263, 18497862 +BRCA1 S4F Inconclusive Inconclusive 23867111 +BRCA1 L246V Likely Neutral Likely Neutral 23867111 +BRCA1 K45N Inconclusive Inconclusive 22034435, 16403807 +BRCA1 C24Y Inconclusive Inconclusive 22034435, 16403807 +BRCA1 N1730S Likely Neutral Likely Neutral 15172985, 20516115 +BRCA1 Y1703S Likely Oncogenic Likely Loss-of-function 23613828 +BRCA1 R1751P Likely Oncogenic Likely Loss-of-function 15172985, 20516115 +BRCA1 V1653M Likely Oncogenic Likely Loss-of-function 15004537, 15172985, 20516115 +BRCA1 E1060A Likely Neutral Likely Neutral 23867111 +BRCA1 S308A Inconclusive Inconclusive 23867111 +BRCA1 C61G Likely Oncogenic Loss-of-function 14729053, 20103620, 23867111, 22034435, 15569676, 23161852, 16403807 +BRCA1 K1487R Likely Oncogenic Likely Loss-of-function 18992264 +BRCA1 C24R Likely Oncogenic Loss-of-function 20103620, 23161852 +BRCA1 S4P Inconclusive Inconclusive 22034435, 16403807 +BRCA1 M1783L Likely Neutral Likely Neutral 20516115 +BRCA1 V271L Likely Neutral Neutral 23867111 +BRCA1 A1823T Likely Neutral Likely Neutral 15172985, 12142080, 20516115 +BRCA1 T1691K Likely Oncogenic Likely Loss-of-function 20516115 +BRCA1 A1752G Likely Neutral Likely Neutral 23842040 +BRCA1 H1402Y Likely Neutral Likely Neutral 15689452 +BRCA1 D1778H Inconclusive Inconclusive 15172985, 9809041 +BRCA1 L165P Likely Neutral Likely Neutral 23867111 +BRCA1 V1804A Inconclusive Inconclusive 15004537 +BRCA1 W1718S Likely Oncogenic Likely Loss-of-function 15172985, 20516115 +BRCA1 R133H Likely Neutral Neutral 23161852 +BRCA1 T1773S Likely Neutral Likely Neutral 15172985, 20516115 +BRCA1 D1692H Likely Oncogenic Likely Loss-of-function 20516115 +BRCA1 D1692Y Likely Oncogenic Likely Loss-of-function 15172985, 20516115 +BRCA1 D695N Likely Neutral Likely Neutral 23867111 +BRCA1 L1657P Likely Oncogenic Likely Loss-of-function 15172985, 12496477 +BRCA1 R866C Likely Neutral Likely Neutral 23867111 +BRCA1 G57R Inconclusive Inconclusive 22034435, 16403807 +BRCA1 A1708V Likely Oncogenic Likely Loss-of-function 20516115 +BRCA1 H1805P Likely Neutral Likely Neutral 20516115 +BRCA1 N1819S Likely Neutral Likely Neutral 15172985, 20516115 +BRCA1 V191D Likely Neutral Likely Neutral 23161852 +BRCA1 G1656D Likely Oncogenic Likely Loss-of-function 20516115 +BRCA1 I89N Inconclusive Inconclusive 22034435, 16403807 +BRCA1 K50E Inconclusive Inconclusive 22034435, 16403807 +BRCA1 A1789S Likely Neutral Likely Neutral 20516115 +BRCA1 M1008I Likely Neutral Likely Neutral 23867111 +BRCA1 A1752P Likely Oncogenic Loss-of-function 15172985, 15689452, 20516115 +BRCA1 K65M Inconclusive Inconclusive 22034435, 16403807 +BRCA1 V1804D Inconclusive Inconclusive 15004537, 15172985, 23867111, 15350310, 20516115, 17308087 +BRCA1 D1778N Likely Neutral Likely Neutral 15172985, 20516115 +BRCA1 R1753T Likely Oncogenic Loss-of-function 23867111, 20516115, 17308087 +BRCA1 R1758G Inconclusive Inconclusive 15172985, 9544765 +BRCA1 L1844R Likely Neutral Likely Neutral 20516115 +BRCA1 Truncating Mutations Likely Oncogenic Likely Loss-of-function 12483515, 11358863, 20608970, 12947386 +BRCA1 V191I Likely Neutral Likely Neutral 23867111 +BRCA1 Y1703H Likely Oncogenic Likely Loss-of-function 15172985, 10811118, 11573086 +BRCA1 V1713A Oncogenic Loss-of-function 20516115, 17308087, 9159158 +BRCA1 S1613C Likely Neutral Likely Neutral 18992264 +BRCA1 M1689T Likely Oncogenic Likely Loss-of-function 20516115 +BRCA1 C47G Likely Oncogenic Loss-of-function 20103620, 22034435, 23161852, 16403807 +BRCA1 T47D Likely Neutral Likely Neutral 15569676 +BRCA1 M1663L Likely Neutral Likely Neutral 20516115 +BRCA1 S1613G Likely Neutral Likely Neutral 9159158 +BRCA1 R170W Likely Neutral Likely Neutral 23867111 +BRCA1 F1695L Likely Neutral Likely Neutral 15172985, 17161371, 20516115 +BRCA1 L63F Inconclusive Inconclusive 22034435, 16403807 +BRCA1 C44Y Oncogenic Loss-of-function 22034435, 21922593, 16403807 +BRCA1 C1767S Likely Neutral Likely Neutral 23867111 +BRCA1 T1691I Likely Oncogenic Likely Loss-of-function 23867111, 20516115 +BRCA1 F1704S Likely Oncogenic Likely Loss-of-function 15172985, 11573086, 12496477 +BRCA1 C360R Likely Neutral Likely Neutral 23867111 +BRCA1 E362H Likely Neutral Likely Neutral 23867111 +BRCA1 R170Q Likely Neutral Neutral 23161852 +BRCA1 M1411T Inconclusive Inconclusive 23867111, 19369211, 16793542, 15770685 +BRCA1 W1782C Likely Neutral Likely Neutral 23867111 +BRCA1 E1586G Likely Neutral Likely Neutral 23613828 +BRCA1 G1743R Likely Oncogenic Likely Loss-of-function 15172985, 12496477 +BRCA1 W1837G Likely Oncogenic Likely Loss-of-function 15172985, 9799248, 20516115 +BRCA1 G1706E Likely Oncogenic Loss-of-function 15172985, 23867111, 20516115, 17308087 +BRCA1 T1852S Inconclusive Inconclusive 15172985 +BRCA1 L358R Likely Neutral Likely Neutral 23867111 +BRCA1 S1448G Likely Neutral Likely Neutral 23867111 +BRCA1 G1763V Likely Oncogenic Likely Loss-of-function 20516115 +BRCA1 C39S Inconclusive Inconclusive 22034435, 16403807 +BRCA1 Q1826H Likely Neutral Likely Neutral 18992264, 20516115 +BRCA1 D1733G Likely Neutral Likely Neutral 15172985, 10811118, 17161371, 20516115, 11157798 +BRCA1 Deletion Likely Oncogenic Likely Loss-of-function 12483515, 18501021, 27452521, 12670888, 9354803 +BRCA1 L147F Likely Neutral Likely Neutral 23867111 +BRCA1 M1628V Likely Oncogenic Likely Loss-of-function 15689452 +BRCA1 M1400V Inconclusive Inconclusive 23867111, 19369211, 16793542, 15770685 +BRCA1 L82P Inconclusive Inconclusive 22034435, 16403807 +BRCA1 V1736A Likely Oncogenic Loss-of-function 15004537, 15172985, 23867111, 20516115, 17308087 +BRCA1 E1794D Likely Neutral Likely Neutral 23867111, 20516115, 17308087 +BRCA1 W1718L Likely Oncogenic Likely Loss-of-function 23613828 +BRCA1 S1715N Likely Oncogenic Loss-of-function 15172985, 20516115, 11157798 +BRCA1 M1783I Likely Neutral Likely Neutral 20516115 +BRCA1 L1564P Likely Oncogenic Likely Loss-of-function 17308087 +BRCA1 V1665M Likely Neutral Likely Neutral 15172985, 20516115, 11157798 +BRCA1 H41R Likely Oncogenic Loss-of-function 20103620, 22034435, 23161852, 16403807 +BRCA1 S1140G Likely Neutral Likely Neutral 23867111 +BRCA1 Y856H Likely Neutral Likely Neutral 23867111 +BRCA1 I26N Inconclusive Inconclusive 22034435, 16403807 +BRCA1 M1663K Likely Neutral Likely Neutral 20516115 +BRCA1 D1739E Likely Oncogenic Likely Loss-of-function 15004537, 15172985, 20516115 +BRCA1 T77M Inconclusive Inconclusive 22034435, 16403807 +BRCA1 R1699L Likely Oncogenic Likely Loss-of-function 15172985, 11573086, 20516115 +BRCA1 G1738R Likely Oncogenic Loss-of-function 15172985, 20516115, 17308087 +BRCA1 K1110del Likely Neutral Likely Neutral 23867111 +BRCA1 V1714G Likely Oncogenic Likely Loss-of-function 20516115 +BRCA1 N132K Likely Neutral Neutral 23867111, 18680205, 23161852 +BRCA1 R1751Q Likely Neutral Likely Neutral 9150149, 15172985, 20516115 +BRCA1 T826K Inconclusive Inconclusive 23867111, 10635334 +BRCA1 V1688del Likely Oncogenic Likely Loss-of-function 23867111 +BRCA1 D1818G Inconclusive Inconclusive 20516115 +BRCA1 Q1409L Likely Neutral Likely Neutral 23613828 +BRCA1 R1443G Likely Neutral Likely Neutral 23867111, 17308087 +BRCA1 P1859R Likely Neutral Likely Neutral 15172985, 20516115 +BRCA1 G1803A Likely Oncogenic Likely Loss-of-function 15172985, 20516115 +BRCA1 D1344H Inconclusive Inconclusive 25416589 +BRCA1 G1788D Likely Oncogenic Likely Loss-of-function 15172985, 20516115, 17308087 +BRCA1 C39R Inconclusive Inconclusive 22034435, 16403807 +BRCA1 R1699Q Likely Oncogenic Loss-of-function 15172985, 23867111, 11573086, 20516115, 11157798 +BRCA1 L52F Likely Neutral Neutral 20103620, 22034435, 23161852, 16403807 +BRCA1 H1862L Likely Neutral Likely Neutral 23867111 +BRCA1 D1739V Likely Oncogenic Loss-of-function 23867111, 20516115 +BRCA1 P142H Likely Neutral Neutral 23867111, 23161852 +BRCA1 Q12Y Inconclusive Inconclusive 22034435, 16403807 +BRCA1 Q1785H Likely Neutral Likely Neutral 20516115, 17308087 +BRCA1 S186Y Likely Neutral Neutral 23867111, 23161852 +BRCA1 T1685A Likely Oncogenic Likely Loss-of-function 15172985, 20516115 +BRCA1 K38N Inconclusive Inconclusive 22034435, 16403807 +BRCA1 I21V Likely Neutral Neutral 20103620, 23161852 +BRCA1 M1775V Likely Neutral Likely Neutral 15172985, 11573086, 8942979 +BRCA1 S1497A Likely Neutral Likely Neutral 23867111 +BRCA1 P1771L Likely Neutral Likely Neutral 15172985, 20516115 +BRCA1 C1787S Likely Neutral Likely Neutral 15172985, 11573086, 20516115 +BRCA1 N550H Likely Neutral Likely Neutral 18680205 +BRCA1 P1812S Inconclusive Inconclusive 15172985 +BRCA1 V1534M Likely Neutral Likely Neutral 23867111, 17308087 +BRCA1 A1708E Oncogenic Loss-of-function 15172985, 23867111, 8751436, 11573086, 15923272, 8942979, 20516115, 21922593, 11157798, 9159158, 7939630 +BRCA1 M1R Likely Oncogenic Likely Loss-of-function 21922593 +BRCA1 H1746N Likely Oncogenic Likely Loss-of-function 15172985, 20516115 +BRCA1 E1660G Likely Oncogenic Likely Loss-of-function 15172985, 12496477 +BRCA1 Y105C Likely Neutral Neutral 23867111, 23161852 +BRCA1 V1833E Likely Oncogenic Likely Loss-of-function 15172985, 10811118 +BRCA1 Q1756C Likely Oncogenic Likely Loss-of-function 8942979 +BRCA1 V1696L Likely Oncogenic Likely Loss-of-function 15172985, 20516115 +BRCA1 M1775E Likely Oncogenic Likely Loss-of-function 15172985, 11573086, 8942979 +BRCA1 D96N Inconclusive Inconclusive 22034435, 16403807 +BRCA1 D67Y Likely Neutral Neutral 20103620, 23867111, 23161852 +BRCA1 T1685I Likely Oncogenic Loss-of-function 15172985, 15689452, 20516115 +BRCA1 M18T Oncogenic Loss-of-function 20103620, 23867111, 23161852, 21922593 +BRCA1 S1655F Likely Oncogenic Loss-of-function 15004537, 23867111, 20516115, 17308087 +BRCA1 V1809F Likely Oncogenic Likely Loss-of-function 15172985, 15689452, 20516115 +BRCA1 S1651P Inconclusive Inconclusive 23867111 +BRCA1 T1700A Likely Oncogenic Loss-of-function 20516115, 17308087 +BRCA1 Y1853* Oncogenic Loss-of-function 15004537, 14729053, 8942979, 15569676, 21922593 +BRCA1 A1843P Likely Oncogenic Likely Loss-of-function 15172985, 11595708, 20516115 +BRCA1 I1807S Likely Oncogenic Likely Loss-of-function 15172985, 12496477 +BRCA1 M1775K Likely Oncogenic Loss-of-function 15172985, 18285836, 11573086, 8942979, 20516115 +BRCA1 M1689R Likely Oncogenic Likely Loss-of-function 15172985, 20516115 +BRCA1 L1664P Likely Neutral Likely Neutral 15172985, 20516115, 17308087 +BRCA1 D1692N Likely Neutral Likely Neutral 15172985, 10196379, 20516115, 11157798 +BRCA1 L28P Inconclusive Inconclusive 22034435, 16403807 +BRCA1 F1734S Likely Oncogenic Likely Loss-of-function 15172985, 20516115 +BRCA1 S72R Inconclusive Inconclusive 22034435, 16403807 +BRCA1 P1812R Likely Neutral Likely Neutral 23867111 +BRCA1 F1761S Likely Oncogenic Loss-of-function 15172985, 10811118, 20516115 +BRCA1 Y1853C Likely Oncogenic Loss-of-function 23842040, 20516115 +BRCA1 V1808A Likely Neutral Likely Neutral 15004537, 15172985, 20516115 +BRCA1 E23fs Oncogenic Loss-of-function 14729053, 23867111, 27454287, 27454289, 15569676, 9145676, 14576434 +BRCA1 H1686R Likely Oncogenic Likely Loss-of-function 23867111 +BRCA1 V1809A Likely Neutral Likely Neutral 15172985, 20516115 +BRCA1 V1833M Likely Oncogenic Likely Loss-of-function 15004537, 18992264, 15172985, 12142080, 20516115 +BRCA1 C27A Likely Oncogenic Loss-of-function 20103620, 23161852 +BRCA1 N1236K Likely Neutral Likely Neutral 23867111 +BRCA1 L1705P Likely Oncogenic Likely Loss-of-function 15172985, 10811118, 11573086 +BRCA1 M1652T Inconclusive Inconclusive 15004537, 15172985, 9585608, 20516115 +BRCA1 F79S Inconclusive Inconclusive 22034435, 16403807 +BRCA1 S1512I Likely Neutral Likely Neutral 18680205, 15689452 +BRCA1 M18K Inconclusive Inconclusive 22034435, 16403807 +BRCA1 F1734L Likely Oncogenic Likely Loss-of-function 15172985, 12496477 +BRCA1 E1214K Likely Neutral Likely Neutral 23867111 +BRCA1 S1486C Likely Neutral Likely Neutral 23867111 +BRCA1 S1473P Likely Neutral Likely Neutral 23613828 +BRCA1 R1726G Likely Neutral Likely Neutral 20516115 +BRCA1 D245V Likely Neutral Likely Neutral 23867111 +BRCA1 T231M Likely Neutral Likely Neutral 23867111 +BRCA1 A1669S Likely Neutral Likely Neutral 15172985, 20516115, 11157798 +BRCA1 N1647K Likely Neutral Likely Neutral 20516115 +BRCA1 S1841R Likely Oncogenic Likely Loss-of-function 20516115 +BRCA1 D1546N Inconclusive Inconclusive 17308087 +BRCA1 D1739G Likely Oncogenic Loss-of-function 15004537, 15172985, 23867111, 20516115 +BRCA1 V11A Inconclusive Inconclusive 18493658 +BRCA1 P1771R Likely Neutral Likely Neutral 20516115 +BRCA1 S1297del Likely Neutral Likely Neutral 23867111 +BRCA1 Q1811R Likely Oncogenic Likely Loss-of-function 15172985, 20516115 +BRCA1 L668F Likely Neutral Likely Neutral 23867111 +BRCA1 M1783T Inconclusive Inconclusive 15004537, 15172985, 20516115 +BRCA1 D1778G Likely Neutral Likely Neutral 15172985, 20516115 +BRCA1 N810Y Likely Neutral Likely Neutral 23867111 +BRCA1 P1749R Oncogenic Loss-of-function 14729053, 15172985, 8751436, 15569676, 10635334, 20516115, 21922593, 9159158 +BRCA1 V1741G Likely Oncogenic Likely Loss-of-function 12497638, 15172985, 20516115 +BRCA1 I15T Inconclusive Inconclusive 22034435, 16403807 +BRCA1 T1720I Likely Neutral Likely Neutral 15004537 +BRCA1 S1722F Likely Oncogenic Loss-of-function 15172985, 9799248, 10196379, 20516115 +BRCA1 D1739Y Likely Oncogenic Likely Loss-of-function 15172985, 20516115 +BRCA1 M1628T Likely Neutral Likely Neutral 23867111, 15350310, 15689452 +BRCA1 S988A Likely Neutral Likely Neutral 23867111 +BRCA1 M1652I Likely Neutral Likely Neutral 18992264, 15172985, 23867111, 9326340, 12215251, 9523200, 20516115, 21922593, 9159158 +BRCA1 S1841A Likely Oncogenic Likely Loss-of-function 21922593 +BRCA1 P1812A Likely Oncogenic Likely Loss-of-function 15172985, 17020472 +BRCA1 A1789T Oncogenic Loss-of-function 23867111, 18680205 +BRCA1 G1738E Likely Oncogenic Loss-of-function 15172985, 10811118, 20516115, 17308087, 11157798 +BRCA1 R1835P Likely Oncogenic Likely Loss-of-function 20516115 +BRCA1 D1851E Likely Neutral Likely Neutral 20516115 +BRCA1 L1764P Likely Oncogenic Loss-of-function 15172985, 23867111, 20516115, 17308087 +BRCA1 E1735K Inconclusive Inconclusive 15172985, 23867111, 9809041 +BRCA1 E1682V Likely Neutral Likely Neutral 20516115 +BRCA1 E1346K Likely Neutral Likely Neutral 23867111 +BRAF V600K Oncogenic Gain-of-function 16273091, 22663011, 12068308, 25265492, 24508103, 25287827, 25399551, 15035987 Planchard et al. Abstract# 8009, ASCO 2013 http://meetinglibrary.asco.org/content/112427-132 +BRAF K601Q Likely Oncogenic Gain-of-function 19206169 +BRAF D594A Likely Oncogenic Gain-of-function 14678966, 20141835, 15035987 +BRAF G469E Likely Oncogenic Likely Gain-of-function 15150094, 22510884, 15035987, 16439621 +BRAF V600_K601delinsE Oncogenic Gain-of-function 26045855, 23833300 +BRAF G478C Likely Neutral Loss-of-function 22926515 +BRAF FAM131B-BRAF Fusion Likely Oncogenic Gain-of-function 15630448, 21424530 +BRAF L597S Likely Oncogenic Likely Gain-of-function 22798288, 26643848 +BRAF G464R Likely Oncogenic Gain-of-function 15046639 +BRAF Q201H Inconclusive Inconclusive 18060073 +BRAF D594Y Likely Oncogenic Likely Gain-of-function 23833300, 20141835, 16439621 +BRAF L485_Q494del Likely Oncogenic Likely Gain-of-function 26732095 +BRAF A728V Likely Oncogenic Gain-of-function 15035987 +BRAF W531C Likely Neutral Likely Neutral 19206169 +BRAF T599I Likely Oncogenic Gain-of-function 15035987 +BRAF L485_P490delinsF Likely Oncogenic Likely Gain-of-function 26732095 +BRAF F595L Likely Oncogenic Gain-of-function 15150094, 15035987 +BRAF K601N Likely Oncogenic Gain-of-function 24270325, 26343582 +BRAF D594G Likely Oncogenic Likely Gain-of-function 23833300, 18794803, 20141835, 16439621 +BRAF L485_P490del Oncogenic Gain-of-function 26732095 +BRAF R671Q Likely Oncogenic Likely Gain-of-function 28174173 +BRAF G466R Likely Oncogenic Likely Gain-of-function 16364920, 15046639, 15035987 +BRAF D594E Likely Oncogenic Gain-of-function 20978199 Noeparast et al. Abstract# 11091, ASCO 2015 http://meeting.ascopubs.org/cgi/content/abstract/33/15_suppl/11091 +BRAF G596R Likely Oncogenic Gain-of-function 14678966, 16364920, 15035987 +BRAF T599_V600insEAT Likely Oncogenic Likely Gain-of-function 16501605 +BRAF T488_P492del Likely Oncogenic Likely Gain-of-function 26732095 +BRAF T599_V600insETT Likely Oncogenic Likely Gain-of-function 16501605 +BRAF L505H Oncogenic Gain-of-function 25515853, 24112705, 24283590 +BRAF T599insTT Oncogenic Gain-of-function 21190184 +BRAF D287H Likely Oncogenic Likely Gain-of-function 26343582 +BRAF I463S Likely Neutral Likely Neutral 15150094, 15035987 +BRAF K601E Likely Oncogenic Gain-of-function 22798288, 24583796, 24933606, 26643848, 23248257, 15035987 +BRAF D594V Likely Oncogenic Gain-of-function 14678966, 19376813, 15035987, 16439621 +BRAF K483M Likely Oncogenic Likely Gain-of-function 19376813, 23533272, 15035987, 27025703 +BRAF T599dup Oncogenic Gain-of-function 23833300, 21190184, 19363522 +BRAF G464E Likely Neutral Likely Neutral 15150094, 20141835, 15035987 +BRAF T529N Likely Neutral Likely Neutral 15573099, 20538618 +BRAF S467A Likely Oncogenic Gain-of-function 19376813, 16439621 +BRAF T599R Oncogenic Gain-of-function 25120313, 19206169 +BRAF V600M Oncogenic Gain-of-function 23463675, 16273091, 12068308, 15035987, 25382067 +BRAF L597R Likely Oncogenic Likely Gain-of-function 22798288, 26643848 +BRAF V600D_K601insFGLAT Oncogenic Gain-of-function 17297294 +BRAF S151A Likely Oncogenic Likely Gain-of-function 21478863 +BRAF N581S Likely Oncogenic Likely Gain-of-function 15035987 +BRAF R462I Likely Neutral Neutral 15150094, 15035987 +BRAF SND1-BRAF Fusion Oncogenic Gain-of-function 25266736, 25985019, 22745804, 24345920 +BRAF F468C Oncogenic Gain-of-function 15150094 +BRAF E501G Likely Neutral Likely Neutral 16474404, 16439621 +BRAF Y472C Likely Oncogenic Gain-of-function 22649091 +BRAF G469del Likely Oncogenic Likely Gain-of-function 23833300 +BRAF TRIM24-BRAF Fusion Likely Oncogenic Gain-of-function 15630448, 24345920 +BRAF p61BRAF Oncogenic Gain-of-function 22113612 +BRAF D594N Likely Oncogenic Gain-of-function 22798288 Noeparast et al. Abstract# 11091, ASCO 2015 http://meeting.ascopubs.org/cgi/content/abstract/33/15_suppl/11091 +BRAF Q257R Likely Oncogenic Gain-of-function 19376813, 16474404, 16439621 +BRAF V600D Oncogenic Gain-of-function 23317446, 20551065, 16273091, 12068308, 15035987 +BRAF A598V Likely Oncogenic Gain-of-function 19200582 +BRAF MKRN1-BRAF Fusion Likely Oncogenic Likely Gain-of-function 18974108, 26314551, 15630448, 23817572 +BRAF R506_K507insVLR Likely Oncogenic Gain-of-function 23817572 +BRAF L597Q Likely Oncogenic Gain-of-function 26343582, 22798288, 26643848 +BRAF L485F Likely Oncogenic Gain-of-function 16474404, 16439621 +BRAF G464V Oncogenic Gain-of-function 15150094, 12068308, 15035987 +BRAF KIAA1549-BRAF Fusion Oncogenic Gain-of-function 18974108, 23533272, 24345920 +BRAF V600R Oncogenic Gain-of-function 16273091, 12068308, 23473613, 15035987, 23490649 +BRAF L485_P490delinsY Likely Oncogenic Likely Gain-of-function 26732095 +BRAF AGK-BRAF Fusion Oncogenic Gain-of-function 26314551, 23890088, 24135138 +BRAF G469V Likely Oncogenic Likely Gain-of-function 25870796, 23401075 +BRAF G469R Likely Oncogenic Gain-of-function 26150740, 24920063, 16096377, 26343582, 26619011 +BRAF T529I Likely Neutral Likely Neutral 15573099, 20538618 +BRAF E275K Likely Oncogenic Likely Gain-of-function 19206169 +BRAF CUL1-BRAF Fusion Likely Oncogenic Likely Gain-of-function 25985019, 22745804, 15630448, 26324360 +BRAF Fusions Likely Oncogenic Likely Gain-of-function 18974108, 26314551, 25985019, 23890088, 22745804, 15630448, 26324360, 21424530, 24345920 +BRAF T599_V600insV Oncogenic Gain-of-function 16501605 +BRAF A598T Likely Neutral Loss-of-function 26619011, 22926515 +BRAF V600G Likely Oncogenic Gain-of-function 20735442, 16273091, 12068308, 26287849, 15035987 +BRAF G469L Likely Oncogenic Likely Gain-of-function 24920063, 24035431 +BRAF AKAP9-BRAF Fusion Oncogenic Gain-of-function 15630448 +BRAF A246P Likely Oncogenic Gain-of-function 16474404 +BRAF V487_P492delinsA Likely Oncogenic Likely Gain-of-function 26732095 +BRAF T241P Likely Oncogenic Likely Gain-of-function 19206169 +BRAF V471F Oncogenic Gain-of-function 25348715 +BRAF G596V Likely Oncogenic Likely Gain-of-function 19376813, 16439621 +BRAF PAPSS1-BRAF Fusion Likely Oncogenic Gain-of-function 15630448, 24345920 +BRAF E501K Inconclusive Inconclusive 17603482, 16474404 +BRAF N486_P490del Likely Oncogenic Likely Gain-of-function 26732095, 18060073 +BRAF G466A Likely Oncogenic Gain-of-function 17724477, 15035987 +BRAF P490_Q494del Likely Oncogenic Likely Gain-of-function 26732095 +BRAF R509H Likely Neutral Loss-of-function 20179705 +BRAF V600delinsYM Oncogenic Gain-of-function 22752848 +BRAF N581Y Likely Oncogenic Likely Gain-of-function 19474002, 26084293, 19276360, 15035987 +BRAF E586K Likely Oncogenic Gain-of-function 15035987 +BRAF L584F Inconclusive Inconclusive 23658559 +BRAF I326V Likely Neutral Likely Neutral 17603482 +BRAF N581D Likely Oncogenic Likely Gain-of-function 16474404 +BRAF K483E Likely Oncogenic Likely Gain-of-function 27799065, 23533272, 15035987 +BRAF K499E Likely Oncogenic Gain-of-function 16474404, 16439621 +BRAF R462E Likely Oncogenic Likely Gain-of-function 25155755 +BRAF G596C Likely Oncogenic Gain-of-function Noeparast et al. Abstract# 11091, ASCO 2015 http://meeting.ascopubs.org/cgi/content/abstract/33/15_suppl/11091 +BRAF Amplification Oncogenic Gain-of-function 15467732, 24055054, 25618114, 22395615, 21098728 +BRAF G469A Oncogenic Gain-of-function 23833300, 12068308, 22510884, 15035987, 22773810, 16439621 +BRAF V600E Oncogenic Gain-of-function 20179705, 16273091, 23153539, 12068308, 15035987 +BRAF T529M Likely Neutral Likely Neutral 15573099, 20538618 +BRAF L597V Oncogenic Gain-of-function 26343582, 12068308, 26643848, 15035987 +BRAF G466E Likely Oncogenic Gain-of-function 16364920, 15035987, 24446311 +BRAF G466V Likely Oncogenic Gain-of-function 22649091, 24202393, 16364920, 15035987, 16439621 +BRCA2 A2351G Inconclusive Inconclusive 18824701 +BRCA2 S2483N Inconclusive Inconclusive 18824701 +BRCA2 R2520Q Likely Neutral Likely Neutral 18451181 +BRCA2 I1349T Inconclusive Inconclusive 17924331 +BRCA2 K2729N Likely Neutral Likely Neutral 17924331, 18451181 +BRCA2 D806H Inconclusive Inconclusive 17924331 +BRCA2 T2515I Inconclusive Inconclusive 18375895 +BRCA2 K2472T Inconclusive Inconclusive 18375895 +BRCA2 A75P Inconclusive Inconclusive 17924331 +BRCA2 R2888C Inconclusive Inconclusive 17924331 +BRCA2 R2304C Inconclusive Inconclusive 18824701 +BRCA2 R3052W Likely Oncogenic Likely Loss-of-function 18451181 +BRCA2 N1102Y Inconclusive Inconclusive 17924331 +BRCA2 M784V Inconclusive Inconclusive 18824701 +BRCA2 R2418G Inconclusive Inconclusive 18824701 +BRCA2 N2113S Inconclusive Inconclusive 17924331 +BRCA2 K607T Inconclusive Inconclusive 18375895 +BRCA2 V1643A Inconclusive Inconclusive 18824701 +BRCA2 A2643G Likely Neutral Likely Neutral 18451181 +BRCA2 L929S Inconclusive Inconclusive 18824701 +BRCA2 S1670A Inconclusive Inconclusive 18375895 +BRCA2 R2659K Likely Oncogenic Loss-of-function 17924331, 18451181, 12624152 +BRCA2 R1190W Inconclusive Inconclusive 17924331 +BRCA2 T2681R Inconclusive Inconclusive 18824701 +BRCA2 E2856A Likely Neutral Likely Neutral 16489001, 18824701 +BRCA2 T2250A Inconclusive Inconclusive 17924331 +BRCA2 N372H Likely Neutral Likely Neutral 18451181 +BRCA2 S206C Likely Oncogenic Likely Loss-of-function 22962691 +BRCA2 N517S Inconclusive Inconclusive 18824701 +BRCA2 E2663V Likely Oncogenic Likely Loss-of-function 17924331, 16489001, 18451181 +BRCA2 R2318Q Inconclusive Inconclusive 16489001 +BRCA2 D3095E Likely Oncogenic Likely Loss-of-function 17924331, 18451181 +BRCA2 G1771D Inconclusive Inconclusive 17924331 +BRCA2 R2784W Likely Oncogenic Likely Loss-of-function 18451181 +BRCA2 D935N Inconclusive Inconclusive 18375895 +BRCA2 P168T Inconclusive Inconclusive 17924331 +BRCA2 P1819S Likely Neutral Likely Neutral 17924331, 18824701 +BRCA2 H1966Y Inconclusive Inconclusive 18824701 +BRCA2 L2865V Likely Neutral Likely Neutral 18451181 +BRCA2 R2502C Inconclusive Inconclusive 17924331 +BRCA2 R174C Likely Oncogenic Likely Loss-of-function 22962691 +BRCA2 N2436I Inconclusive Inconclusive 17924331 +BRCA2 R2842H Inconclusive Inconclusive 17924331 +BRCA2 K1690N Inconclusive Inconclusive 17924331 +BRCA2 F1524V Inconclusive Inconclusive 17924331 +BRCA2 L2106P Inconclusive Inconclusive 18824701 +BRCA2 H1918Y Inconclusive Inconclusive 17924331 +BRCA2 D1352Y Inconclusive Inconclusive 18824701 +BRCA2 C1265S Inconclusive Inconclusive 16489001 +BRCA2 D1280V Inconclusive Inconclusive 17924331 +BRCA2 K513R Likely Neutral Likely Neutral 17924331, 18375895 +BRCA2 Y42C Likely Neutral Likely Neutral 16489001, 18451181, 18824701, 15290653 +BRCA2 S196N Likely Oncogenic Likely Loss-of-function 22962691 +BRCA2 D3170G Inconclusive Inconclusive 17924331 +BRCA2 G173C Likely Oncogenic Likely Loss-of-function 22962691 +BRCA2 A2770T Inconclusive Inconclusive 16489001 +BRCA2 I2285V Likely Neutral Likely Neutral 17924331, 18824701 +BRCA2 V211I Likely Oncogenic Likely Loss-of-function 19179552, 23451180, 22962691 +BRCA2 G2274V Inconclusive Inconclusive 16489001 +BRCA2 L2647P Likely Oncogenic Likely Loss-of-function 18451181 +BRCA2 D191G Likely Oncogenic Likely Loss-of-function 22962691 +BRCA2 C554W Inconclusive Inconclusive 17924331 +BRCA2 R2602T Likely Oncogenic Likely Loss-of-function 18424508, 22505045 +BRCA2 A1170V Inconclusive Inconclusive 18824701 +BRCA2 T3211K Inconclusive Inconclusive 18824701 +BRCA2 D1420Y Inconclusive Inconclusive 18824701 +BRCA2 R3052Q Inconclusive Inconclusive 17924331 +BRCA2 L1904V Inconclusive Inconclusive 17924331 +BRCA2 R2842C Likely Oncogenic Likely Loss-of-function 23108138 +BRCA2 W2626C Inconclusive Inconclusive 17924331 +BRCA2 T630I Inconclusive Inconclusive 17924331 +BRCA2 G2748D Likely Oncogenic Likely Loss-of-function 17924331, 18451181 +BRCA2 N56T Inconclusive Inconclusive 17924331 +BRCA2 K1434I Inconclusive Inconclusive 18824701 +BRCA2 N588D Inconclusive Inconclusive 18824701 +BRCA2 N1878K Inconclusive Inconclusive 18824701 +BRCA2 I2627F Likely Oncogenic Likely Loss-of-function 17924331, 18451181 +BRCA2 P655R Inconclusive Inconclusive 18824701, 15290653 +BRCA2 C1365Y Inconclusive Inconclusive 17924331 +BRCA2 M2676T Inconclusive Inconclusive 18824701 +BRCA2 V3079I Inconclusive Inconclusive 17924331 +BRCA2 D2723G Likely Oncogenic Likely Loss-of-function 17924331, 18451181 +BRCA2 D2723H Likely Oncogenic Likely Loss-of-function 16489001, 18451181, 15290653 +BRCA2 V894I Inconclusive Inconclusive 17924331 +BRCA2 C3198R Inconclusive Inconclusive 17924331 +BRCA2 T2722R Inconclusive Inconclusive 17924331 +BRCA2 G602R Inconclusive Inconclusive 17924331 +BRCA2 S1172L Likely Neutral Likely Neutral 17924331, 18375895, 18824701 +BRCA2 A2717S Inconclusive Inconclusive 18375895 +BRCA2 N1228D Inconclusive Inconclusive 17924331 +BRCA2 T3349A Inconclusive Inconclusive 17924331 +BRCA2 T582P Inconclusive Inconclusive 17924331 +BRCA2 R2502H Inconclusive Inconclusive 18824701 +BRCA2 P375S Inconclusive Inconclusive 17924331 +BRCA2 Q2858R Inconclusive Inconclusive 18375895 +BRCA2 Deletion Oncogenic Loss-of-function 12483515, 18501021, 27452521, 11239455, 22193408, 16199546 +BRCA2 S326R Inconclusive Inconclusive 18824701 +BRCA2 V2969M Inconclusive Inconclusive 17924331 +BRCA2 D2723A Likely Oncogenic Likely Loss-of-function 18451181 +BRCA2 S1733F Inconclusive Inconclusive 17924331 +BRCA2 Y3098H Inconclusive Inconclusive 17924331 +BRCA2 S869L Inconclusive Inconclusive 16489001 +BRCA2 V1306I Inconclusive Inconclusive 17924331 +BRCA2 S384F Likely Neutral Likely Neutral 16489001, 18824701 +BRCA2 V2908G Likely Neutral Likely Neutral 17924331, 18451181 +BRCA2 L209F Likely Neutral Likely Neutral 22962691 +BRCA2 R2973C Likely Neutral Likely Neutral 17924331, 18451181, 18824701 +BRCA2 T1354M Inconclusive Inconclusive 17924331 +BRCA2 D2312V Inconclusive Inconclusive 17924331 +BRCA2 I1929V Inconclusive Inconclusive 17924331 +BRCA2 L2721H Inconclusive Inconclusive 18824701 +BRCA2 H2074N Inconclusive Inconclusive 17924331 +BRCA2 L2396F Inconclusive Inconclusive 17924331 +BRCA2 Y3092C Inconclusive Inconclusive 17924331 +BRCA2 Q1396R Inconclusive Inconclusive 17924331 +BRCA2 Truncating Mutations Likely Oncogenic Likely Loss-of-function 20878484, 24312913, 11239455, 22193408, 10570174 +BRCA2 S2670L Likely Neutral Likely Neutral 16489001 +BRCA2 N987I Inconclusive Inconclusive 18824701 +BRCA2 Q2384K Inconclusive Inconclusive 17924331 +BRCA2 S142I Likely Oncogenic Likely Loss-of-function 21638052 +BRCA2 E3002K Likely Oncogenic Likely Loss-of-function 21947752, 23108138, 20694749 +BRCA2 K2950N Likely Neutral Likely Neutral 17924331, 18375895 +BRCA2 L1019V Inconclusive Inconclusive 17924331 +BRCA2 R18H Inconclusive Inconclusive 18375895 +BRCA2 D2665G Likely Neutral Likely Neutral 17924331, 16489001 +BRCA2 R2336P Likely Oncogenic Likely Loss-of-function 22505045, 9150172 +BRCA2 K2411T Inconclusive Inconclusive 17924331 +BRCA2 R2659T Likely Oncogenic Likely Loss-of-function 18451181 +BRCA2 N2048I Inconclusive Inconclusive 17924331 +BRCA2 N2829R Likely Oncogenic Likely Loss-of-function 22505045 +BRCA2 N319T Likely Neutral Likely Neutral 18451181 +BRCA2 E462G Likely Neutral Likely Neutral 17924331, 18451181 +BRCA2 G1529R Inconclusive Inconclusive 17924331 +BRCA2 S1424C Inconclusive Inconclusive 18824701 +BRCA2 I2675V Likely Oncogenic Likely Loss-of-function 18424508 +BRCA2 R2108H Inconclusive Inconclusive 17924331 +BRCA2 R2336H Likely Oncogenic Loss-of-function 17924331, 18451181, 18489799 +BRCA2 G1194D Inconclusive Inconclusive 17924331 +BRCA2 L2653P Likely Oncogenic Likely Loss-of-function 17924331, 18451181 +NF2 Truncating Mutations Likely Oncogenic Likely Loss-of-function 19545378, 8755919, 22825583, 9643284 +NF2 Q324L Likely Neutral Likely Neutral 11448944 +NF2 A211D Likely Oncogenic Likely Loss-of-function 21383154, 20178741 +NF2 L535P Likely Oncogenic Likely Loss-of-function 21383154, 20178741, 10712203, 11448944 +NF2 L46R Likely Oncogenic Likely Loss-of-function 21383154, 20178741 +NF2 L64P Likely Oncogenic Likely Loss-of-function 20178741, 11448944 +NF2 T352M Likely Neutral Likely Neutral 10712203, 11448944 +NF2 K79E Likely Oncogenic Likely Loss-of-function 10712203, 11448944 +NF2 K413E Inconclusive Inconclusive 21383154, 11448944 +NF2 E106G Likely Oncogenic Likely Loss-of-function 11448944 +NF2 Q538P Likely Oncogenic Likely Loss-of-function 11448944 +NF2 Deletion Likely Oncogenic Likely Loss-of-function 24726726, 15645494, 19451229, 22825583, 9643284 +PAX8 PAX8-PPAR? Fusion Oncogenic Gain-of-function 17131411, 10958784 +NFE2L2 W24S Likely Oncogenic Gain-of-function 24142871, 18757741, 1875774 +NFE2L2 D77H Likely Oncogenic Likely Gain-of-function 16888629, 26619011 +NFE2L2 E82V Likely Oncogenic Likely Gain-of-function 12167159 +NFE2L2 E79K Likely Oncogenic Gain-of-function 24142871, 18757741, 1875774 +NFE2L2 G31R Oncogenic Gain-of-function 27147599 +NFE2L2 G31A Oncogenic Gain-of-function 27147599 +NFE2L2 D29N Likely Oncogenic Gain-of-function 24142871, 18757741, 1875774 +NFE2L2 G81S Likely Oncogenic Gain-of-function 24142871, 18757741, 1875774 +NFE2L2 I28T Likely Oncogenic Gain-of-function 24142871, 18757741, 1875774 +NFE2L2 T80A Likely Oncogenic Gain-of-function 24142871, 18757741, 1875774 +NFE2L2 E82G Likely Oncogenic Gain-of-function 23365135 +NFE2L2 D29H Likely Oncogenic Gain-of-function 24142871, 18757741, 1875774 +NFE2L2 W24C Likely Oncogenic Gain-of-function 24142871, 18757741, 1875774 +NFE2L2 G81D Likely Oncogenic Gain-of-function 24142871, 18757741, 1875774 +NFE2L2 E79Q Likely Oncogenic Gain-of-function 24142871, 18757741, 1875774 +NFE2L2 G31V Oncogenic Gain-of-function 27147599 +NFE2L2 E82D Likely Oncogenic Likely Gain-of-function 24130096, 18757741 +NFE2L2 V32G Likely Oncogenic Gain-of-function 24142871, 18757741, 1875774 +NFE2L2 T80R Likely Oncogenic Gain-of-function 24142871, 18757741, 1875774 +NFE2L2 W24R Likely Oncogenic Gain-of-function 24142871, 18757741, 1875774 +NFE2L2 T80K Oncogenic Gain-of-function 24130096, 27147599, 18757741 +NFE2L2 D29Y Likely Oncogenic Gain-of-function 24142871, 18757741, 1875774 +NFE2L2 G81R Likely Oncogenic Gain-of-function 24142871, 18757741, 1875774 +NFE2L2 L30F Likely Oncogenic Gain-of-function 24142871, 18757741, 1875774 +GLI1 R380A Likely Oncogenic Likely Loss-of-function 25476449 +GLI1 Amplification Oncogenic Gain-of-function 3563490, 1825351 +FUBP1 Truncating Mutations Likely Oncogenic Likely Loss-of-function 22072542, 22588899, 21817013, 24117486 +BTK C481S Likely Oncogenic Gain-of-function 25189416, 24869598 +BTK R544S Likely Oncogenic Likely Gain-of-function 20052711, 20826165 +BTK Y551F Likely Neutral Loss-of-function 20052711, 9188445, 20826165 +NFKBIA M37K Likely Neutral Likely Gain-of-function 23708964 +NFKBIA S36Y Likely Neutral Likely Gain-of-function 23864385 +NFKBIA E14* Likely Neutral Gain-of-function 18412279 +NFKBIA S32I Likely Neutral Gain-of-function 14523047 +GNA11 R183C Oncogenic Gain-of-function 21083380 +GNA11 Q209L Oncogenic Gain-of-function 21083380 +KDR C482R Likely Oncogenic Likely Gain-of-function 18931684, 25411163, 21712447 +KDR Q472H Likely Oncogenic Likely Gain-of-function 24793135, 24599305, 21712447 Mockus et al. Abstract# 73, AACR 2015 http://cancerres.aacrjournals.org/content/75/15_Supplement/73 +KDR Amplification Oncogenic Gain-of-function 11114740, 26578684 +KDR A1065T Likely Oncogenic Gain-of-function 19723655 +KDR D717V Oncogenic Gain-of-function 19723655 +KDR R961W Inconclusive Inconclusive 27004155 +KDR T771R Inconclusive Inconclusive 26422291, 19723655 +BCL10 Truncating Mutations Likely Oncogenic Likely Loss-of-function 10319863, 9989495 +BCL10 Deletion Likely Oncogenic Likely Loss-of-function 10319863, 9989495, 10845924 +GNAQ R183Q Likely Oncogenic Likely Gain-of-function 22236444 +GNAQ Q209L Oncogenic Gain-of-function 19078957, 1328859, 21083380 +GNAS R201H Oncogenic Gain-of-function 26257060, 24498386 +GNAS Q227R Likely Oncogenic Likely Gain-of-function 2549426 +GNAS R201C Oncogenic Gain-of-function 25288233, 20531296 +GNAS R844H Oncogenic Gain-of-function 15148396, 19423757 +GNAS Q227L Likely Oncogenic Likely Gain-of-function 2549426 +MGA Deletion Likely Oncogenic Likely Loss-of-function 10601024 +MGA Truncating Mutations Likely Oncogenic Likely Loss-of-function 23039309 +KIT W557_V560del Likely Oncogenic Likely Gain-of-function 23775962, 18955458 +KIT N822Y Likely Oncogenic Likely Gain-of-function 21689725, 18724244 +KIT Y570H Likely Oncogenic Likely Gain-of-function 21642685 +KIT A504_Y505ins Likely Oncogenic Likely Gain-of-function 16551858 +KIT Amplification Likely Oncogenic Likely Gain-of-function 15650049, 18506689, 16166280, 21523721, 19779861, 15869870, 24868028, 17189383 +KIT P577_W582delinsPYD Likely Oncogenic Likely Gain-of-function 23775962 +KIT D816E Likely Oncogenic Likely Gain-of-function 16551858, 25239608, 16397263 +KIT D52N Likely Oncogenic Likely Gain-of-function 9168438 +KIT V560G Oncogenic Gain-of-function 15790786, 16434489, 14645423, 16954519, 16397263 +KIT Exon 9 mutations Oncogenic Gain-of-function 18235121, 12181401, 23076159, 17662946, 24061512, 18955458, 16098458, 15451219 +KIT V559D Oncogenic Gain-of-function 15790786, 17372901, 18980976, 18955458, 16954519, 25605837, 15930355, 17699867, 9438854 +KIT D820Y Likely Oncogenic Likely Switch-of-function 14977822, 16551858, 18623623, 23840364, 25239608, 22614970, 18955458, 15930355, 17699867 +KIT P551_M552del Likely Oncogenic Likely Gain-of-function 18955458 +KIT K558_E562del Likely Oncogenic Likely Gain-of-function 25735500 +KIT P551_E554del Oncogenic Gain-of-function 25239608, 16954519 +KIT Exon 11 mutations Oncogenic Gain-of-function 18235121, 17372901, 25079768, 12181401, 17046465, 19282169, 25641662, 16098458, 15451219, 23177515, 19536093 +KIT K558_V559del Likely Oncogenic Likely Gain-of-function 18955458, 16954519 +KIT N505I Oncogenic Gain-of-function 24317392 +KIT W557G Likely Oncogenic Likely Gain-of-function 10224103, 25079768, 15342366 +KIT R634W Oncogenic Gain-of-function 15790786 +KIT W557_K558del Oncogenic Gain-of-function 14645423, 25239608, 16954519, 15930355, 17699867 +KIT D419del Likely Oncogenic Gain-of-function 16143141, 23599150 +KIT T417_D419delinsRG Oncogenic Gain-of-function 15790786 +KIT V569_L576del Likely Oncogenic Likely Gain-of-function 16551858, 15930355 +KIT L576P Oncogenic Gain-of-function 22357254, 17372901, 26264378, 18980976, 25605837, 15930355, 19671763, 22068222, 23775962, 21642685, 25695690, 18955458, 16954519 +KIT V559I Likely Oncogenic Gain-of-function 17259998 +KIT T670I Oncogenic Gain-of-function 16551858, 17545544, 23840364, 16954519, 17699867 +KIT N822K Oncogenic Gain-of-function 15790786, 23840364, 21482694, 24490049, 21642685, 25695690, 22614970, 16954519, 26316776, 17699867 +KIT Y553N Likely Oncogenic Likely Gain-of-function 21969494, 22357254 +KIT D820G Likely Oncogenic Likely Gain-of-function 16551858, 18623623, 23840364, 18955458, 16954519, 21456006 +KIT D816G Oncogenic Gain-of-function 25239608 +KIT K558delinsNP Oncogenic Gain-of-function 11526490, 25239608, 18955458, 16954519 +KIT T574insTQLPYD Likely Oncogenic Likely Gain-of-function 15930355 +KIT N822I Oncogenic Gain-of-function 21689725 +KIT W557R Likely Oncogenic Gain-of-function 14977822, 10224103, 19018266, 22357254, 21953054, 25079768, 21325067, 18980976, 21906875, 21642685, 20859122, 12888812 +KIT N463S Likely Oncogenic Likely Gain-of-function 21642685 +KIT C809G Likely Oncogenic Likely Gain-of-function 17139461, 18955458, 16954519 +KIT K550_K558del Oncogenic Gain-of-function 16954519, 9438854 +KIT D816F Oncogenic Gain-of-function 16397263 +KIT S501_A502dup Likely Oncogenic Gain-of-function 22324351 +KIT I653T Likely Oncogenic Likely Gain-of-function 21642685 +KIT E554_I571del Likely Oncogenic Likely Gain-of-function 16954519 +KIT V560E Likely Oncogenic Likely Gain-of-function 21690468, 22350270, 25239608 +KIT S709F Likely Oncogenic Likely Gain-of-function 16551858 +KIT P577_D579del Likely Oncogenic Likely Gain-of-function 22357254 +KIT D60N Likely Oncogenic Gain-of-function 24211109, 16226710 +KIT D572A Likely Oncogenic Gain-of-function 19865100 +KIT D816N Likely Oncogenic Gain-of-function 11369651 +KIT S476I Likely Oncogenic Gain-of-function 19865100 +KIT V559G Oncogenic Gain-of-function 23348204, 12569358 +KIT N564_Y578del Likely Oncogenic Likely Gain-of-function 16952044 +KIT T574_R588delinsL Likely Oncogenic Likely Gain-of-function 18955458 +KIT K550_W557del Oncogenic Gain-of-function 25239608 +KIT P551_V555del Oncogenic Gain-of-function 9438854 +KIT N822H Likely Oncogenic Gain-of-function 14645423, 18955458, 16954519 +KIT I563_L576del Likely Oncogenic Likely Gain-of-function 15930355 +KIT V559A Likely Oncogenic Likely Gain-of-function 15897563, 19812602, 16908931, 9438854 +KIT Y568_L576delinsVN Likely Oncogenic Likely Gain-of-function 18955458 +KIT D816A Likely Oncogenic Likely Gain-of-function 18955458, 16397263 +KIT V555_V559del Likely Oncogenic Gain-of-function 18955458, 15930355 +KIT L576del Likely Oncogenic Gain-of-function 19802003, 12717247 +KIT D820E Likely Oncogenic Likely Gain-of-function 19461405, 25886408, 15685537 +KIT K558N Likely Oncogenic Likely Gain-of-function 18980976 +KIT K550_V555delinsI Oncogenic Gain-of-function 9438854 +KIT C443Y Likely Oncogenic Gain-of-function 19865100 +KIT Y553_Q556del Likely Oncogenic Gain-of-function 15690055 +KIT D816Y Oncogenic Gain-of-function 15790786, 15167915, 16397263, 15725473 +KIT D579del Likely Oncogenic Likely Gain-of-function 24419427, 18955458 +KIT K509I Likely Oncogenic Gain-of-function 19865100 +KIT V654A Likely Oncogenic Gain-of-function 18623623, 23840364, 21642685, 18955458, 16954519, 16751810 +KIT Y418_D419del Likely Oncogenic Gain-of-function 22825855, 19603346, 16143141 +KIT V559_G565del Likely Oncogenic Likely Gain-of-function 16551858 +KIT V559C Likely Oncogenic Likely Gain-of-function 15897563, 21642685, 25695690, 9438854 +KIT A502_Y503dup Oncogenic Gain-of-function 22350270, 25239608, 18955458, 16954519, 21527588, 17699867 +KIT Q556_K558del Likely Oncogenic Likely Gain-of-function 19369884, 17372901, 25079768 +KIT V559_V560del Oncogenic Gain-of-function 16551858, 15790786, 16954519 +KIT F522C Likely Oncogenic Gain-of-function 15070706 +KIT H697Y Oncogenic Gain-of-function 19861435 +KIT D814V Oncogenic Gain-of-function 12569358 +KIT D816H Oncogenic Gain-of-function 18623623, 16956837, 18980976, 25304235, 25239608, 18955458, 16954519, 16397263 +KIT E490K Likely Oncogenic Likely Gain-of-function 22357254 +KIT E839K Likely Neutral Neutral 15790786 +KIT N655K Likely Oncogenic Likely Gain-of-function 17489795 +KIT P573_D579del Likely Oncogenic Gain-of-function 12569358, 9438854 +KIT K642E Likely Oncogenic Gain-of-function 24855380, 23940219, 11526490, 25695690, 25304235, 25239608, 14645423, 16954519 +KIT V555_L576del Likely Oncogenic Gain-of-function 23840364 +KIT V560del Oncogenic Gain-of-function 22357254, 16551858, 19861435, 15201427, 25605837 +KIT V560D Oncogenic Gain-of-function 23775962, 16551858, 23840364, 25239608, 18955458, 16954519, 25605837, 9438854 +KIT Y823D Oncogenic Gain-of-function 20633291, 22069175, 16551858, 18623623, 22301675, 18980976, 22089421, 18955458, 16954519, 15930355 +KIT E554_V559del Likely Oncogenic Likely Gain-of-function 18980976 +KIT M541L Likely Oncogenic Likely Gain-of-function 25015329, 21757432, 15790786, 20664593, 21498700, 18795925, 16307017 +KIT D820A Likely Oncogenic Likely Gain-of-function 23840364, 25239608, 18955458, 16954519 +KIT R796G Likely Neutral Loss-of-function 20824047 +KIT 550_592del Oncogenic Gain-of-function 18235121, 17372901, 25079768, 12181401, 15365079, 16098458, 15451219 +KIT V530I Oncogenic Gain-of-function 20339585, 16081693 +KIT W557_V559delinsC Likely Oncogenic Likely Gain-of-function 18955458 +KIT V559del Likely Oncogenic Gain-of-function 23993026, 15236194, 10485475, 16751810 +KIT V852I Likely Oncogenic Likely Gain-of-function 21642685 +KIT P838L Likely Oncogenic Likely Gain-of-function 21642685 +KIT Y578C Likely Oncogenic Gain-of-function 23567324 +KIT T417_D419delinsI Oncogenic Gain-of-function 15790786 +KIT D737N Inconclusive Inconclusive 26863566 +KIT P551_W557delinsL Likely Oncogenic Likely Gain-of-function 25239608 +KIT D816V Oncogenic Gain-of-function 15972446, 19193436, 7479840, 26002753, 16434489, 16397263, 15725473, 15790786, 17545544, 22301675, 16254134, 14645423, 16779792, 23659595, 23416972 +KIT M552_W557del Likely Oncogenic Likely Gain-of-function 16551858, 16954519 +KIT Y553_K558del Likely Oncogenic Likely Gain-of-function 16954519 +KIT E554_K558del Likely Oncogenic Likely Gain-of-function 18955458, 16954519, 15930355 +KIT A829P Likely Oncogenic Likely Gain-of-function 18623623, 18980976, 21642685, 25239608, 18955458 +KIT M552_K558del Likely Oncogenic Likely Gain-of-function 25239608 +KIT Exon 11 deletions Oncogenic Gain-of-function 18235121, 17372901, 25079768, 12181401, 15365079, 16098458, 15451219 +FGF19 Amplification Likely Oncogenic Likely Gain-of-function 24265351, 21397858, 22309595 +MED12 G44S Oncogenic Switch-of-function 24746821 +MED12 Exon 1 mutations Oncogenic Gain-of-function 24980722 +MED12 Deletion Likely Oncogenic Likely Loss-of-function 23178117 +MED12 L1224F Likely Oncogenic Likely Gain-of-function 12218053, 26619011, 17612495, 26383637 +MED12 Exon 2 mutations Oncogenic Likely Gain-of-function 23738515, 25038752, 23913526, 21868628 +MED12 G44D Oncogenic Switch-of-function 24746821 +NOTCH1 Deletion Likely Oncogenic Likely Gain-of-function 22077063, 23734977, 20852131 +NOTCH1 V1578del Likely Oncogenic Likely Gain-of-function 22056382, 24651013, 16618740, 25806268, 15472075, 16738328 +NOTCH1 L1574P Oncogenic Gain-of-function 22056382, 24651013, 16618740, 25806268, 15472075, 16738328 +NOTCH1 L1678P Likely Oncogenic Gain-of-function 22056382, 24651013, 16618740, 25806268, 16738328 +NOTCH1 I1718T Likely Oncogenic Gain-of-function 22056382, 24651013, 16618740, 25806268, 16738328 +NOTCH1 A1701P Likely Oncogenic Gain-of-function 22056382, 24651013, 16618740, 25806268, 16738328 +NOTCH1 P2415del Likely Oncogenic Likely Gain-of-function 24651013, 25564152, 21948802, 15472075 +NOTCH1 L1593P Likely Oncogenic Gain-of-function 22056382, 24651013, 16618740, 25806268, 16738328 +NOTCH1 MIR143-NOTCH1 Fusion Likely Oncogenic Likely Gain-of-function 23999936 +NOTCH1 Q2405Rfs*17 Likely Oncogenic Likely Gain-of-function 24651013, 25564152, 21948802, 15472075 +NOTCH1 L2429V Likely Oncogenic Likely Gain-of-function 24651013, 25564152, 21948802, 15472075 +NOTCH1 V1676D Likely Oncogenic Gain-of-function 22056382, 24651013, 16618740, 25806268, 16738328 +NOTCH1 P2417A Likely Oncogenic Likely Gain-of-function 24651013, 25564152, 21948802, 15472075 +NOTCH1 V1671I Likely Oncogenic Likely Gain-of-function 24651013, 25376516, 15472075, 19340001 +NOTCH1 R1608S Likely Neutral Likely Neutral 24651013, 16738328 +NOTCH1 L1596H Likely Oncogenic Gain-of-function 22056382, 24651013, 16618740, 25806268, 16738328 +NOTCH1 V1605del Likely Oncogenic Likely Gain-of-function 22056382, 24651013, 16618740, 25806268, 15472075, 16738328 +NOTCH1 I1680N Likely Oncogenic Gain-of-function 22056382, 24651013, 16618740, 25806268, 16738328 +NOTCH1 SEC16A1-NOTCH1 Fusion Oncogenic Gain-of-function 22101766 +NOTCH1 G2430A Likely Oncogenic Gain-of-function 20823234 +NOTCH1 Truncating Mutations in the PEST Domain Likely Oncogenic Likely Gain-of-function 22056382, 24651013, 16618740, 25564152, 21948802, 25806268, 15472075 +NOTCH1 Q2416* Likely Oncogenic Likely Gain-of-function 24651013, 25564152, 21948802, 15472075 +NOTCH1 F1592S Likely Oncogenic Gain-of-function 22056382, 24651013, 16618740, 25806268, 16738328 +NOTCH1 Truncating Mutations Upstream of Transactivation Domain Oncogenic Likely Loss-of-function 24651013, 22006338, 21798897, 21798893 +NOTCH1 V1576E Likely Oncogenic Gain-of-function 22056382, 24651013, 16618740, 25806268, 16738328 +NOTCH1 H2428Q Likely Oncogenic Likely Gain-of-function 24651013, 25564152, 21948802, 15472075 +NOTCH1 Fusions Likely Oncogenic Likely Gain-of-function 16688224, 22101766, 23033986 +NOTCH1 R1598P Likely Oncogenic Gain-of-function 22056382, 24651013, 16618740, 25806268, 16738328 +NOTCH1 L1600P Likely Oncogenic Gain-of-function 22056382, 24651013, 16618740, 25806268, 15472075, 16738328 +NOTCH1 P2412T Likely Oncogenic Likely Gain-of-function 24651013, 25564152, 21948802, 15472075 +NOTCH1 A2425T Likely Oncogenic Likely Gain-of-function 24651013, 25564152, 21948802, 15472075 +NOTCH1 I1616T Likely Oncogenic Gain-of-function 22056382, 24651013, 16618740, 25806268, 16738328 +NOTCH1 R1594Q Likely Oncogenic Loss-of-function 24651013, 22006338, 27228302 +NOTCH1 G2420C Likely Oncogenic Likely Gain-of-function 24651013, 25564152, 21948802, 15472075 +NOTCH1 I1616N Likely Oncogenic Gain-of-function 22056382, 24651013, 16618740, 25806268, 16738328 +NOTCH2 2010_2471trunc Likely Oncogenic Likely Gain-of-function 21378989 +NOTCH2 1_2009trunc Likely Oncogenic Likely Loss-of-function 22006338 +RAC1 P29S Oncogenic Gain-of-function 2546593, 22842228, 23284172, 25056119, 25465943 +RAC1 Q61R Likely Oncogenic Gain-of-function 26619011 +RAC1 C18Y Likely Oncogenic Gain-of-function 28115009 +RAC1 Amplification Likely Oncogenic Gain-of-function 24072884, 23474757 +RAC1 G12V Oncogenic Gain-of-function 23382236, 23284172 +RAC1 C157Y Likely Oncogenic Gain-of-function 23382236 +RAC1 P29L Oncogenic Gain-of-function 23382236 +DNMT3A R882C Likely Oncogenic Likely Gain-of-function 24656771, 27010239 +DNMT3A R882H Likely Oncogenic Likely Gain-of-function 22722925, 24167195, 24656771, 25416276, 27010239 +DNMT3A Truncating Mutations Likely Oncogenic Likely Loss-of-function 21067377, 25964253, 24614070 +DNMT3A Deletion Likely Oncogenic Likely Loss-of-function 21067377, 27636998 +DNMT3B DNMT3B7 Likely Oncogenic Likely Switch-of-function 20587527, 23315164, 25607950, 22815530, 17353906 +DNMT3B Amplification Likely Oncogenic Likely Gain-of-function 25470049, 22810696 +RAD21 Truncating Mutations Likely Oncogenic Likely Loss-of-function 28116354, 25006131 +RAD21 Deletion Likely Oncogenic Likely Loss-of-function 28116354, 25006131 +RAD51 Truncating Mutations Likely Oncogenic Likely Loss-of-function +RAD51C A126T Likely Neutral Neutral 21990120, 26261251, 20400964, 21980511 +RAD51C Truncating Mutations Likely Oncogenic Likely Loss-of-function 20400963, 20400964, 21616938 +RAD51C G264S Likely Neutral Neutral 21990120, 26261251, 20400964 +RAD51B HMGA2-RAD51B Fusion Likely Oncogenic Likely Switch-of-function 9892177, 26787895, 11450849 +RAD51D Truncating Mutations Likely Oncogenic Likely Loss-of-function 23372765, 21822267, 22986143 +KRAS G12C Oncogenic Gain-of-function 25705018, 24256730, 16051643, 26841430 +KRAS G12D Oncogenic Gain-of-function 17349581, 24300897, 19296721, 26037647, 11751631, 15093544, 20570890, 20147967 +KRAS A146V Likely Oncogenic Gain-of-function 3043178, 26841430 +KRAS G12V Oncogenic Gain-of-function 20516123, 20949621, 25359494, 20570890, 12957286, 20147967 +KRAS Wildtype Likely Neutral Neutral 22810696, 12506171 NCCN Colon 2.2017 https://www.nccn.org/professionals/physician_gls/pdf/colon.pdf +KRAS T74P Likely Oncogenic Gain-of-function 19075190 +KRAS G13C Oncogenic Gain-of-function 25705018, 21079152 +KRAS Q61R Oncogenic Gain-of-function 21993244, 25363767, 24651010, 25437878 +KRAS T58I Oncogenic Gain-of-function 20949621, 16474405, 18509354 +KRAS Y71H Oncogenic Gain-of-function 23059812 +KRAS Q22R Likely Oncogenic Likely Gain-of-function 20949621, 21263000 +KRAS A18D Oncogenic Gain-of-function 19490892 +KRAS G13D Oncogenic Gain-of-function 20978259, 26037647, 22722830, 20147967 +KRAS R164Q Inconclusive Inconclusive 26274561, 20147967 +KRAS P34R Oncogenic Gain-of-function 8995293, 17875937, 20949621, 16474405 +KRAS E62K Oncogenic Gain-of-function 27147599 +KRAS G60R Oncogenic Gain-of-function 20949621 +KRAS F156L Oncogenic Gain-of-function 20949621, 17601930, 7877967 +KRAS G12R Oncogenic Gain-of-function 24893629, 26037647, 21831957, 22722830 +KRAS Q61H Oncogenic Gain-of-function 25705018, 21993244, 24651010, 20147967 +KRAS K117N Oncogenic Gain-of-function 20570890, 20147967 +KRAS Y32S Likely Oncogenic Gain-of-function 11333268, 26841430 +KRAS A11_G12insGA Oncogenic Gain-of-function 24642870 +KRAS G12A Oncogenic Gain-of-function 26662311, 26037647, 25013473, 23182985 +KRAS F28L Oncogenic Gain-of-function 25600866, 20949621, 16474405 +KRAS L19F Oncogenic Gain-of-function 17150185, 20147967 +KRAS K147E Oncogenic Gain-of-function 23059812 +KRAS Y40A Inconclusive Inconclusive 11333268, 26841430 +KRAS G12S Oncogenic Gain-of-function 26184075, 25284075 +KRAS P34L Oncogenic Gain-of-function 17875937, 20949621 +KRAS V14I Oncogenic Gain-of-function 25359213, 20949621, 16474405 +KRAS Q22K Oncogenic Gain-of-function 23059812, 11095964, 20570890 +KRAS Y64A Oncogenic Gain-of-function 12628188, 26841430 +KRAS Q22E Oncogenic Gain-of-function 20949621, 21263000 +KRAS Amplification Likely Oncogenic Likely Gain-of-function 23099803, 24874471, 20841479, 23404247 +KRAS G60D Inconclusive Inconclusive 21632860 +KRAS G12F Likely Oncogenic Likely Gain-of-function 20871262 +KRAS A59G Oncogenic Gain-of-function 27147599, 1221964, 26841430 +KRAS D119N Likely Oncogenic Likely Gain-of-function 8552403, 11103938 +KRAS A146T Oncogenic Gain-of-function 19075190, 20570890, 20147967, 2403644 +KRAS E31K Likely Neutral Likely Neutral 20570890, 16483931 +KRAS Q25H Inconclusive Inconclusive 21375404 +KRAS G13E Likely Oncogenic Likely Gain-of-function 19453520, 26619011, 17503413, 19521964 +KRAS K5N Oncogenic Gain-of-function 17875937, 20949621, 25941399 +KRAS S65N Oncogenic Gain-of-function 8626650, 24798740 +KRAS Q61L Oncogenic Gain-of-function 21993244, 25363767, 24651010, 26854029, 25437878 +KRAS D153V Oncogenic Gain-of-function 17875937, 20949621, 16474405, 25941399 +KRAS G10dup Oncogenic Gain-of-function 8955068 +KRAS N116H Inconclusive Inconclusive 26841430 +NPM1 Deletion Likely Oncogenic Likely Loss-of-function 18212245, 19322210, 20877721, 16007073 +NPM1 Truncating Mutations Likely Oncogenic Likely Loss-of-function 19322210, 20877721 +RAF1 S257W Likely Oncogenic Gain-of-function 12077328, 7867061, 17603483 +RAF1 S257L Oncogenic Gain-of-function 12077328, 7867061, 24569458, 17603483 +RAF1 Fusions Likely Oncogenic Likely Gain-of-function 27810072, 19363522, 20526349, 23637631 +RAF1 I448V Oncogenic Gain-of-function 19357705 +RAF1 S259A Oncogenic Gain-of-function 24569458, 20679480 +RAF1 ESRP1-RAF1 Fusion Oncogenic Gain-of-function 20526349 +RAF1 S427G Oncogenic Gain-of-function 16585161, 19357705 +RAF1 S259F Oncogenic Gain-of-function 17603483, 20679480 +RAF1 P261L Likely Oncogenic Likely Gain-of-function 17603483, 20679480 +RAF1 Amplification Oncogenic Gain-of-function 11389083, 21215703, 16517112 Zehir A et al. Nature Medicine 2017 http://doi:10.1038/nm.4333 +RAF1 ATG7-RAF1 Fusion Likely Oncogenic Likely Gain-of-function 23637631 +RAF1 S259P Likely Oncogenic Gain-of-function 20679480 +RAF1 SRGAP3-RAF1 Fusion Oncogenic Gain-of-function 19363522 +RAB35 F161L Oncogenic Gain-of-function 26338797 +RAB35 A151T Oncogenic Gain-of-function 26338797 +HNF1A Truncating Mutations Likely Oncogenic Likely Loss-of-function 12574234, 18003757, 25793983 +HNF1A T196A Likely Neutral Neutral 21170474 +HNF1A Deletion Likely Oncogenic Likely Loss-of-function 12574234, 25793983 +HNF1A P291Qfs*51 Likely Oncogenic Likely Loss-of-function 12574234, 9313763, 16917892 +AKT3 Amplification Oncogenic Gain-of-function 17178867, 24138071, 18451171, 25737557, 15466193, 20647317 +AKT3 E17K Likely Oncogenic Gain-of-function 18813315 +AKT3 Fusions Likely Oncogenic Likely Gain-of-function 22722202 +AKT3 MAGI3-AKT3 Fusion Oncogenic Gain-of-function 22722202 +TCF3 N551K Likely Oncogenic Loss-of-function 24492847, 22885699 +TCF7L2 Truncating Mutations Likely Oncogenic Likely Loss-of-function 10919662, 16547505, 18478343, 18599616, 10485457 +RARA R276W Inconclusive Inconclusive 27148563, 23670176, 19865110, 11438209 +NRAS Q61R Oncogenic Gain-of-function 25277205, 21993244, 20194776, 23515407, 24651010, 19492075 +NRAS G12C Likely Oncogenic Likely Gain-of-function 21993244, 24651010 +NRAS Amplification Inconclusive Inconclusive 26266759, 25263998, 22876308 Zehir A et al. Nature Medicine, 2017 http://doi:10.1038/nm.4333 +NRAS G13D Oncogenic Gain-of-function 26037647, 21993244, 24651010, 22722830 +NRAS G12R Oncogenic Gain-of-function 21993244, 24651010 +NRAS Q61H Oncogenic Gain-of-function 21993244, 20194776, 23515407, 24651010 +NRAS G13V Likely Oncogenic Likely Gain-of-function 20371679, 21993244, 24651010 +NRAS Q61K Oncogenic Gain-of-function 25277205, 21993244, 20194776, 23515407, 24651010, 19492075 +NRAS Q61L Oncogenic Gain-of-function 25277205, 21993244, 20194776, 23515407, 24651010, 19492075 +NRAS T50I Likely Oncogenic Likely Gain-of-function 22817889, 19966803 +NRAS G12D Oncogenic Gain-of-function 21993244, 23687087, 24651010, 25252692, 18372904 +NRAS G12V Oncogenic Gain-of-function 18952898, 21993244, 21478863, 24651010 +NRAS G60E Likely Oncogenic Gain-of-function 19075190, 19966803, 10716188, 21263000 +NRAS T58I Likely Oncogenic Likely Gain-of-function 24265153, 16474405 +RASA1 Deletion Likely Oncogenic Likely Loss-of-function 2173144, 9121432, 9034330, 1689011 +RASA1 Y472H Likely Oncogenic Likely Loss-of-function 26993606 +RASA1 Truncating Mutations Likely Oncogenic Likely Loss-of-function 2173144, 9121432, 9034330, 1689011, 24038909 +RASA1 L481F Likely Oncogenic Likely Loss-of-function 26993606 +BCL2L11 Truncating Mutations Likely Oncogenic Likely Loss-of-function 24737648, 23382048, 26076815, 23559152, 21652541, 26001141, 23116058 +BCL2L11 Single Nucleotide Polymorphism Oncogenic Loss-of-function 24223824 +BCL2L11 Deletion Oncogenic Likely Loss-of-function 22426421, 26076815, 23559152, 23116058 +RB1 R661W Inconclusive Inconclusive 16449662, 7927327, 9420334, 1352883, 18677112 +RB1 Truncating Mutations Likely Oncogenic Likely Loss-of-function 25621664, 22293180, 22205104 +RB1 R621C Likely Oncogenic Likely Loss-of-function 20594292 +RB1 C706F Likely Oncogenic Likely Loss-of-function 18677112 +RB1 L607I Likely Oncogenic Likely Loss-of-function 20594292 +RB1 N480del Likely Neutral Likely Neutral 18677112 +RB1 R698W Likely Oncogenic Likely Loss-of-function 20594292 +RB1 Deletion Likely Oncogenic Likely Loss-of-function 16127685, 17854503, 23960888 +RB1 S567L Likely Oncogenic Likely Loss-of-function 10671068, 9420334 +RB1 C712R Likely Neutral Likely Neutral 18677112 +RB1 W563L Inconclusive Inconclusive 16269091, 10882758 +KDM5A Amplification Likely Oncogenic Likely Gain-of-function 22937203, 2293720 +NTRK1 TFG-NTRK1 Fusion Likely Oncogenic Gain-of-function 7565764, 9488046 +NTRK1 Fusions Likely Oncogenic Likely Gain-of-function 24162815 +NTRK1 NFASC-NTRK1 Fusion Oncogenic Gain-of-function 24647444 +NTRK1 TPM3-NTRK1 Fusion Oncogenic Gain-of-function 2869410, 2927393, 24962792 +NTRK1 S677N Likely Oncogenic Likely Gain-of-function 18270328 +NTRK1 BCAN-NTRK1 Fusion Likely Oncogenic Likely Gain-of-function 24647444 +NTRK1 V710A Likely Neutral Loss-of-function 27272783 +NTRK1 Delta-NTRK1 Fusion Oncogenic Gain-of-function 11073967 +NTRK1 LMNA-NTRK1 Fusion Oncogenic Gain-of-function 24445538 +NTRK1 Amplification Likely Oncogenic Gain-of-function 26496938 +NTRK1 TPR-NTRK1 Fusion Oncogenic Gain-of-function 9172002, 1532241, 7851906 +NTRK1 TRKAIII Splice Variant Oncogenic Gain-of-function 15488758 +NTRK1 MPRIP-NTRK1 Fusion Oncogenic Gain-of-function 24162815 +NTRK1 R342Q Likely Oncogenic Gain-of-function 1695324, 11313867, 23000897, 23636398, 22460905 +NTRK1 CD74-NTRK1 Fusion Oncogenic Gain-of-function 24162815 +NTRK1 CHTOP-NTRK1 Fusion Likely Oncogenic Likely Gain-of-function 24647444, 25384085 +NTRK1 R342W Likely Oncogenic Gain-of-function 1695324, 11313867, 23636398, 22460905 +NTRK2 M713I Likely Neutral Likely Loss-of-function 21242122 +NTRK2 Fusions Likely Oncogenic Likely Gain-of-function 26565381, 25204415, 26216294, 26884591, 24647444, 24445538, 26457764, 26797418, 24162815, 27843590, 26603524 +NTRK2 R734C Likely Neutral Likely Loss-of-function 21242122 +NTRK2 R715G Likely Neutral Likely Neutral 21242122 +NTRK3 Fusions Likely Oncogenic Likely Gain-of-function 26565381, 25204415, 26216294, 26884591, 27843950, 26457764, 26797418, 27148571, 26603524 +NTRK3 ETV6-NTRK3 Fusion Oncogenic Gain-of-function 10702799, 12450792 +NTRK3 G623R Likely Oncogenic Likely Gain-of-function 26884591 +NTRK3 CPEB1-NTRK3 Fusion Oncogenic Gain-of-function 24705251 +NTRK3 BTBD1-NTRK3 Fusion Oncogenic Gain-of-function 24705251 +DUSP4 Deletion Inconclusive Inconclusive 21317287, 19525976 +DDR2 Amplification Likely Oncogenic Likely Gain-of-function 24505276, 26362312, 28099935 +DDR2 L239R Oncogenic Gain-of-function 22328973, 23335507 +DDR2 L63V Oncogenic Gain-of-function 23822953, 22328973 +DDR2 G505S Likely Oncogenic Gain-of-function 23822953, 22328973 +DDR2 G774V Oncogenic Gain-of-function 22328973 +DDR2 T654I Inconclusive Inconclusive 24296828 +DDR2 G253C Oncogenic Gain-of-function 22328973, 23335507 +DDR2 T654M Inconclusive Inconclusive 22328973, 24296828 +DDR2 S768R Likely Oncogenic Likely Gain-of-function 22328973, 25173530 +DDR2 I638F Inconclusive Inconclusive 23822953, 22328973 +SOX17 Deletion Likely Oncogenic Likely Loss-of-function 17655922, 28237397, 24407731, 20716954, 17875931, 18413743, 19301122, 27738313, 21514720, 24153254, 27102016, 22846201 +SOX17 Truncating Mutations Likely Oncogenic Likely Loss-of-function +NSD1 NSD1-NUP98 Fusion Likely Oncogenic Likely Gain-of-function 11895789, 23630019 +NSD1 Fusions Likely Oncogenic Likely Gain-of-function 11895789, 23630019, 27889185 +CASP8 Truncating Mutations Likely Oncogenic Likely Loss-of-function 15531912, 19852930, 15705878, 12949717 +CASP8 G325A Likely Oncogenic Gain-of-function 23659359 +CASP8 Promoter Hypermethylation Likely Oncogenic Loss-of-function 16397500, 10969767, 11593392 +CASP8 CASP8L Likely Oncogenic Loss-of-function 12010809, 10860845, 15735742, 16374545 +CASP8 Deletion Likely Oncogenic Likely Loss-of-function 15531912, 12055196, 15705878 +CASP8 C248T Likely Neutral Neutral 12353035 +RET C618R Oncogenic Gain-of-function 9230192 +RET R833C Likely Oncogenic Likely Gain-of-function 21810974 +RET V804M Oncogenic Gain-of-function 17047083 +RET E768D Likely Oncogenic Likely Gain-of-function 10445857 +RET C634R Oncogenic Gain-of-function 9230192 +RET R886W Oncogenic Gain-of-function 21551259 +RET V804L Likely Oncogenic Likely Gain-of-function 15184865, 9242375 +RET Fusions Likely Oncogenic Likely Gain-of-function 25064355, 24561444, 22327623 +RET E632_L633del Likely Oncogenic Gain-of-function 9191060 +RET C609Y Oncogenic Gain-of-function 9230192 +RET S765P Likely Neutral Loss-of-function 11438491 +RET C634W Likely Oncogenic Likely Gain-of-function 17664273, 9230192 +RET E511K Likely Oncogenic Likely Gain-of-function 20103606, 21551259 +RET M918V Likely Oncogenic Likely Gain-of-function 21810974 +RET K603Q Likely Oncogenic Likely Gain-of-function 15277225, 11746981 +RET S904F Likely Oncogenic Likely Gain-of-function 21810974 +RET C630R Oncogenic Gain-of-function 9230192 +RET S891A Oncogenic Gain-of-function 24561444, 20554711 +RET L790F Oncogenic Gain-of-function 20444924, 15753368 +RET RET-CCDC6 Fusion Oncogenic Gain-of-function 23578175 +RET R897Q Likely Neutral Loss-of-function 11438491 +RET M918T Oncogenic Gain-of-function 8755580, 22584710, 7824936, 9681850, 24561444 +RET C634Y Likely Oncogenic Gain-of-function 9230192 +RET A919V Likely Oncogenic Likely Gain-of-function 19186126 +RET E921K Likely Neutral Loss-of-function 11438491 +RET V804G Likely Neutral Likely Loss-of-function 15184865 +RET G885R Likely Neutral Likely Neutral 25733075, 24336963 +RET M848T Likely Oncogenic Likely Gain-of-function 21810974 +RET T338I Likely Neutral Likely Neutral 21810974 +RET C634S Likely Oncogenic Gain-of-function 15277225 +RET KIF5B-RET Fusion Oncogenic Gain-of-function 22327624 +RET D631G Likely Neutral Likely Neutral 10049754 +RET I852M Likely Oncogenic Likely Gain-of-function 21711375, 11295841 +RET A919P Inconclusive Inconclusive 16928683 +RET D631A Likely Neutral Likely Neutral 10049754 +RET F893L Likely Neutral Loss-of-function 11438491 +RET Y806C Likely Oncogenic Likely Gain-of-function 19029224 +RET Y791F Likely Oncogenic Gain-of-function 15753368, 9506724, 12490841, 17209045 +RET C620R Oncogenic Gain-of-function 9230192 +RET A883F Oncogenic Gain-of-function 24561444 +RET M980T Likely Neutral Likely Neutral 11438491 +RET C611Y Oncogenic Gain-of-function 9230192 +RET V648I Likely Neutral Likely Neutral 21810974 +RET A883T Oncogenic Gain-of-function 15531548, 21810974 +RET R873Q Likely Neutral Loss-of-function 11438491 +RUNX1 Truncating Mutations Likely Oncogenic Likely Loss-of-function 15864279, 15386419, 17394134 +RUNX1 R174Q Oncogenic Loss-of-function 25490895, 21725049, 17290219 +RUNX1 R201Q Likely Oncogenic Loss-of-function 10508512 +RUNX1 RUNX1-RUNX1T1 Fusion Likely Oncogenic Loss-of-function 19414342, 21174539, 4125056, 9819404 +RUNX1 Amplification Oncogenic Gain-of-function 25592647 +RUNX1 D171G Likely Oncogenic Likely Loss-of-function 22318203 +RUNX1 H78Q Likely Oncogenic Loss-of-function 22318203 +RUNX1 D171N Oncogenic Loss-of-function 18192504, 12393679 +RUNX1 R139G Likely Oncogenic Loss-of-function 22318203 +RUNX1 R166Q Likely Oncogenic Loss-of-function 10508512 +RUNX1 R177* Oncogenic Loss-of-function 10068652, 11830488, 15156185 +RUNX1 G42R Inconclusive Inconclusive 18192504, 12874780, 12393679 +RUNX1 Y113* Oncogenic Loss-of-function 18192504 +RUNX1 S291fsX300 Oncogenic Loss-of-function 18192504 +RUNX1 K83N Likely Oncogenic Loss-of-function 11830488, 15156185 +RUNX1 K83E Likely Oncogenic Loss-of-function 11830488, 15156185 +RUNX1 R174* Oncogenic Gain-of-function 26021490, 20549580 +RUNX1 R177Q Oncogenic Loss-of-function 11830488, 18192504 +RUNX1 RUNX1-EVI1 Fusion Likely Oncogenic Loss-of-function 15156182, 19016745 +RUNX1 P173S Oncogenic Loss-of-function 18192504 +RUNX1 W279* Likely Oncogenic Likely Loss-of-function 25893166 +RUNX1 S70fsX93 Oncogenic Loss-of-function 18192504 +RUNX1 R80C Likely Oncogenic Loss-of-function 15156185 +RUNX1 Fusions Likely Oncogenic Likely Loss-of-function 21174539 +RUNX1 A122* Likely Oncogenic Likely Loss-of-function 18192504 +RUNX1 TEL-RUNX1 Fusion Likely Oncogenic Loss-of-function 15156184 diff --git a/synapse_tmp.csv b/synapse_tmp.csv old mode 100644 new mode 100755 From 7eeb1a3d187eebead7ca7ea817fbde0e17311415 Mon Sep 17 00:00:00 2001 From: "Krishnan.N" Date: Tue, 19 Sep 2017 16:36:50 +0530 Subject: [PATCH 6/7] Script to get all the DB's from URL. --- db_get.py | 15 +++++++++++++++ 1 file changed, 15 insertions(+) create mode 100644 db_get.py diff --git a/db_get.py b/db_get.py new file mode 100644 index 0000000..cf55908 --- /dev/null +++ b/db_get.py @@ -0,0 +1,15 @@ +#db_get.py -- get all Databases from URLs and write the CSV into /tmp/DB_name +# + +import csv +import MySQLdb +from urllib import urlretrieve +import os + + +onco_url = "http://oncokb.org/api/v1/utils/allAnnotatedVariants.txt" +print 'retrieving from' + onco_url +urlretrieve(onco_url,"/tmp/oncotxt.txt") + + + From e0e09e8c6d971615387217d06b7919e154f07aa7 Mon Sep 17 00:00:00 2001 From: saamm Date: Wed, 20 Sep 2017 15:19:33 +0530 Subject: [PATCH 7/7] the civic and synapse url --- db_get.py | 10 ++++++++++ 1 file changed, 10 insertions(+) diff --git a/db_get.py b/db_get.py index cf55908..237a1fe 100644 --- a/db_get.py +++ b/db_get.py @@ -11,5 +11,15 @@ print 'retrieving from' + onco_url urlretrieve(onco_url,"/tmp/oncotxt.txt") +civic_url = "https://civic.genome.wustl.edu/downloads/nightly/nightly-ClinicalEvidenceSummaries.tsv" +print 'retrieving from' +civic_url +urlretrieve(civic_url, "/tmp/civic.tsv") + +Synapse_url = 'https://www.synapse.org/Portal/filehandle?entityId=syn2653551&preview=false&proxy=false&xsrfToken=F7228553D367BBB7C8CE655512E8AC5D&version=1' +values = {'username': 'soumya.s@gai.co.in', + 'password': 'GAIcellworks'} +r = requests.post(url, data=values) +print 'retrieving from' + Synapse_url +urlretrieve(synapse_url,"/tmp/synapse.xls")