diff --git a/README.md b/README.md old mode 100644 new mode 100755 diff --git a/candl_tmp.csv b/candl_tmp.csv new file mode 100644 index 0000000..d578af6 --- /dev/null +++ b/candl_tmp.csv @@ -0,0 +1,6 @@ +1,ABL1,T,212,R,9,133738234,ACG,uc004bzw.3,+,634,4,AGG,Chronic Myelocytic Leukemia,3,20519627 +2,ABL1,T,212,R,9,133738235,ACG,uc004bzw.3,+,635,4,AGG,Chronic Myelocytic Leukemia,3,20519627 +2769,AKT1,,0,,14,0,,,,0,0,,Lung,3, +32,AKT1,E,17,K,14,105246550,GAG,uc001ypn.3,-,50,3,AAG,Lung,4,"17611497, 23134728" +157,ARAF,F,351,L,x,47426806,TTC,uc011mlp.3,+,1051,10,TTG,Langerhans Cell Histiocytosis,3,24652991 +2767,BRAF,,0,,7,0,,,,0,0,,"Colon, Astrocytoma",4, diff --git a/civic_tmp.csv b/civic_tmp.csv old mode 100644 new mode 100755 diff --git a/csvrecords.py b/csvrecords.py new file mode 100755 index 0000000..0c9dc64 --- /dev/null +++ b/csvrecords.py @@ -0,0 +1,9 @@ +import csv + +txt_file = r"allAnnotatedVariants.txt" +csv_file = r"mycsv.csv" + +in_txt = csv.reader(open(txt_file, "rb"), delimiter = '\t') +out_csv = csv.writer(open(csv_file, 'wb')) + +out_csv.writerows(in_txt) \ No newline at end of file diff --git a/dataonco.py b/dataonco.py new file mode 100755 index 0000000..426ada5 --- /dev/null +++ b/dataonco.py @@ -0,0 +1,115 @@ +import csv +import pymysql +pymysql.install_as_MySQLdb() +import MySQLdb +from urllib.request import urlretrieve +import os + + +url = "http://oncokb.org/api/v1/utils/allAnnotatedVariants.txt" +urlretrieve(url,"oncotxt.txt") + +with open('oncotxt.txt', 'r') as infile, open('oncocsv.csv', 'w') as outfile: + in_txt = csv.reader(infile, delimiter = '\t') + + out_csv = csv.writer(outfile) + out_csv.writerows(in_txt) +'''with open("test.csv",'r') as f: + with open("oncocsv.csv",'w') as f1: + next(f) # skip header line + for line in f: + f1.write(line)''' + +os.remove('oncotxt.txt') + +def MapOncokb(d): + d['Database'] = 'OncoKB' + d['Mutation'] = 0 + d['Signature'] = 1 + d['Variant'] = 99999 + d['Functionality'] = 3 + d['Impact'] = 99999 + d['Indication'] = 99999 + d['Domain'] = 99999 + d['Classification'] = 99999 + d['Reference'] = 4 + + return d + +def MapFunctionality(str): + functionality = { # OncoKB map + 'Loss-of-function': 'LOF', 'Likely Loss-of-function': 'LOF', + 'Gain-of-function': 'GOF', 'Likely Gain-of-function': 'GOF', + 'Switch-of-function': 'SOF', 'Likely Switch-of-function': 'SOF', + 'Mutation Effect': 'COF', 'Likely Mutation Effect': 'COF', + 'Inconclusive': 'Inconclusive', + 'Neutral': 'Neutral', 'Likely Neutral': 'Neutral', 'null': 'NA', + # + + } + + return functionality[str.strip()] + + +def WriteDB(dbFd, dbMap, row): + + tblRow = 10*['NA'] + + tblRow[0] = dbMap['Database'] + tblRow[1] = row [dbMap['Mutation']] + tblRow[2] = row [dbMap['Signature']] + if (dbMap['Variant'] != 99999): + tblRow[3] = (row [dbMap['Variant']]) + if (dbMap['Functionality'] != 99999): + tblRow[4] = MapFunctionality (row [dbMap['Functionality']]) + if (dbMap['Impact'] != 99999): + tblRow[5] = row [dbMap['Impact']] + if (dbMap['Indication'] != 99999): + tblRow[6] = row [dbMap['Indication']] + if (dbMap['Domain'] != 99999): + tblRow[7] = row [dbMap['Domain']] + if (dbMap['Classification'] != 99999): + tblRow[8] = row [dbMap['Classification']] + if (dbMap['Reference'] != 99999): + tblRow[9] = row [dbMap['Reference']] + + return tblRow + +dbFd = 1 + +myfile = open('finalrecord.csv', 'w') +writer = csv.writer(myfile, delimiter=',') + +oncoMap = dict() +MapOncokb(oncoMap) + + +with open('oncocsv.csv', 'r') as csvFd: + reader = csv.reader(csvFd, delimiter=',') + next(reader) + for row in reader: + lin = WriteDB(dbFd, oncoMap, row) + writer.writerow(lin) +os.remove('oncocsv.csv') + + +database = MySQLdb.connect(host='localhost', user='root', passwd='root') +cursor = database.cursor() +create_database = "CREATE DATABASE IF NOT EXISTS cellworksDATA" +cursor.execute(create_database) +database = MySQLdb.connect(host='localhost', user='root', passwd='root', db='cellworksDATA') +cursor = database.cursor() +create_table = "CREATE TABLE IF NOT EXISTS cellworksTABLE (Data VARCHAR(255), Mutation VARCHAR(255), Signature VARCHAR(255), Variant VARCHAR(255), Functionality VARCHAR(255), Impact VARCHAR(255), Indication VARCHAR(255), Domain VARCHAR(255), Classification VARCHAR(255), Reference VARCHAR(255))" +cursor.execute(create_table) +with open('finalrecord.csv', "r") as file: + reader = csv.reader(file) + for row in reader: + if len(row) == 10: + cursor.execute('INSERT INTO cellworksTABLE (Data,Mutation,Signature,Variant,Functionality,Impact,Indication,Domain,Classification,Reference) VALUES("%s","%s","%s","%s","%s","%s","%s","%s","%s","%s")', (row[0], row[1], row[2], row[3], row[4], row[5], row[6], row[7], row[8], row[9])) + else: + print('Error in row: ') + print(row) +database.commit() +cursor.close() + +os.remove('finalrecord.csv') diff --git a/dataonco.py~ b/dataonco.py~ new file mode 100755 index 0000000..41fde2e --- /dev/null +++ b/dataonco.py~ @@ -0,0 +1,116 @@ +import csv +import pymysql +pymysql.install_as_MySQLdb() +import MySQLdb +from urllib.request import urlretrieve +import os + + +url = "http://oncokb.org/api/v1/utils/allAnnotatedVariants.txt" +urlretrieve(url,"oncotxt.txt") + +with open('oncotxt.txt', 'r') as infile, open('oncocsv.csv', 'w') as outfile: + in_txt = csv.reader(infile, delimiter = '\t') + + out_csv = csv.writer(outfile) + out_csv.writerows(in_txt) +'''with open("test.csv",'r') as f: + with open("oncocsv.csv",'w') as f1: + next(f) # skip header line + for line in f: + f1.write(line)''' + +os.remove('oncotxt.txt') + +def MapOncokb(d): + d['Database'] = 'OncoKB' + d['Mutation'] = 0 + d['Signature'] = 1 + d['Variant'] = 99999 + d['Functionality'] = 3 + d['Impact'] = 99999 + d['Indication'] = 99999 + d['Domain'] = 99999 + d['Classification'] = 99999 + d['Reference'] = 4 + + return d + +def MapFunctionality(str): + functionality = { # OncoKB map + 'Loss-of-function': 'LOF', 'Likely Loss-of-function': 'LOF', + 'Gain-of-function': 'GOF', 'Likely Gain-of-function': 'GOF', + 'Switch-of-function': 'SOF', 'Likely Switch-of-function': 'SOF', + 'Mutation Effect': 'COF', 'Likely Mutation Effect': 'COF', + 'Inconclusive': 'Inconclusive', + 'Neutral': 'Neutral', 'Likely Neutral': 'Neutral', 'null': 'NA', + # + + } + + return functionality[str.strip()] + + +def WriteDB(dbFd, dbMap, row): + + tblRow = 10*['NA'] + + tblRow[0] = dbMap['Database'] + tblRow[1] = row [dbMap['Mutation']] + tblRow[2] = row [dbMap['Signature']] + if (dbMap['Variant'] != 99999): + tblRow[3] = (row [dbMap['Variant']]) + if (dbMap['Functionality'] != 99999): + tblRow[4] = MapFunctionality (row [dbMap['Functionality']]) + if (dbMap['Impact'] != 99999): + tblRow[5] = row [dbMap['Impact']] + if (dbMap['Indication'] != 99999): + tblRow[6] = row [dbMap['Indication']] + if (dbMap['Domain'] != 99999): + tblRow[7] = row [dbMap['Domain']] + if (dbMap['Classification'] != 99999): + tblRow[8] = row [dbMap['Classification']] + if (dbMap['Reference'] != 99999): + tblRow[9] = row [dbMap['Reference']] + + return tblRow + +dbFd = 1 + +myfile = open('finalrecord.csv', 'w') +writer = csv.writer(myfile, delimiter=',') + +oncoMap = dict() +MapOncokb(oncoMap) + + +with open('oncocsv.csv', 'r') as csvFd: + reader = csv.reader(csvFd, delimiter=',') + next(reader) + for row in reader: + lin = WriteDB(dbFd, oncoMap, row) + writer.writerow(lin) +os.remove('oncocsv.csv') + + + +database = MySQLdb.connect(host='localhost', user='root', passwd='root') +cursor = database.cursor() +create_database = "CREATE DATABASE IF NOT EXISTS cellworksDATA" +cursor.execute(create_database) +database = MySQLdb.connect(host='localhost', user='root', passwd='root', db='cellworksDATA') +cursor = database.cursor() +create_table = "CREATE TABLE IF NOT EXISTS cellworksTABLE (Data VARCHAR(255), Mutation VARCHAR(255), Signature VARCHAR(255), Variant VARCHAR(255), Functionality VARCHAR(255), Impact VARCHAR(255), Indication VARCHAR(255), Domain VARCHAR(255), Classification VARCHAR(255), Reference VARCHAR(255))" +cursor.execute(create_table) +with open('finalrecord.csv', "r") as file: + reader = csv.reader(file) + for row in reader: + if len(row) == 10: + cursor.execute('INSERT INTO cellworksTABLE (Data,Mutation,Signature,Variant,Functionality,Impact,Indication,Domain,Classification,Reference) VALUES("%s","%s","%s","%s","%s","%s","%s","%s","%s","%s")', (row[0], row[1], row[2], row[3], row[4], row[5], row[6], row[7], row[8], row[9])) + else: + print('Error in row: ') + print(row) +database.commit() +cursor.close() + +os.remove('finalrecord.csv') diff --git a/dataonco2.py b/dataonco2.py new file mode 100644 index 0000000..6dc330f --- /dev/null +++ b/dataonco2.py @@ -0,0 +1,113 @@ +import csv +import MySQLdb +from urllib import urlretrieve +import os + + +url = "http://oncokb.org/api/v1/utils/allAnnotatedVariants.txt" +urlretrieve(url,"oncotxt.txt") + +with open('oncotxt.txt', 'r') as infile, open('oncocsv.csv', 'w') as outfile: + in_txt = csv.reader(infile, delimiter = '\t') + + out_csv = csv.writer(outfile) + out_csv.writerows(in_txt) +'''with open("test.csv",'r') as f: + with open("oncocsv.csv",'w') as f1: + next(f) # skip header line + for line in f: + f1.write(line)''' + +os.remove('oncotxt.txt') + +def MapOncokb(d): + d['Database'] = 'OncoKB' + d['Mutation'] = 0 + d['Signature'] = 1 + d['Variant'] = 99999 + d['Functionality'] = 3 + d['Impact'] = 99999 + d['Indication'] = 99999 + d['Domain'] = 99999 + d['Classification'] = 99999 + d['Reference'] = 4 + + return d + +def MapFunctionality(str): + functionality = { # OncoKB map + 'Loss-of-function': 'LOF', 'Likely Loss-of-function': 'LOF', + 'Gain-of-function': 'GOF', 'Likely Gain-of-function': 'GOF', + 'Switch-of-function': 'SOF', 'Likely Switch-of-function': 'SOF', + 'Mutation Effect': 'COF', 'Likely Mutation Effect': 'COF', + 'Inconclusive': 'Inconclusive', + 'Neutral': 'Neutral', 'Likely Neutral': 'Neutral', 'null': 'NA', + # + + } + + return functionality[str.strip()] + + +def WriteDB(dbFd, dbMap, row): + + tblRow = 10*['NA'] + + tblRow[0] = dbMap['Database'] + tblRow[1] = row [dbMap['Mutation']] + tblRow[2] = row [dbMap['Signature']] + if (dbMap['Variant'] != 99999): + tblRow[3] = (row [dbMap['Variant']]) + if (dbMap['Functionality'] != 99999): + tblRow[4] = MapFunctionality (row [dbMap['Functionality']]) + if (dbMap['Impact'] != 99999): + tblRow[5] = row [dbMap['Impact']] + if (dbMap['Indication'] != 99999): + tblRow[6] = row [dbMap['Indication']] + if (dbMap['Domain'] != 99999): + tblRow[7] = row [dbMap['Domain']] + if (dbMap['Classification'] != 99999): + tblRow[8] = row [dbMap['Classification']] + if (dbMap['Reference'] != 99999): + tblRow[9] = row [dbMap['Reference']] + + return tblRow + +dbFd = 1 + +myfile = open('finalrecord.csv', 'w') +writer = csv.writer(myfile, delimiter=',') + +oncoMap = dict() +MapOncokb(oncoMap) + + +with open('oncocsv.csv', 'r') as csvFd: + reader = csv.reader(csvFd, delimiter=',') + next(reader) + for row in reader: + lin = WriteDB(dbFd, oncoMap, row) + writer.writerow(lin) +#os.remove('oncocsv.csv') + + +database = MySQLdb.connect(host='localhost', user='root', passwd='root') +cursor = database.cursor() +create_database = "CREATE DATABASE IF NOT EXISTS cellworksDATA" +cursor.execute(create_database) +database = MySQLdb.connect(host='localhost', user='root', passwd='root', db='cellworksDATA') +cursor = database.cursor() +create_table = "CREATE TABLE IF NOT EXISTS cellworksTABLE (Data VARCHAR(255), Mutation VARCHAR(255), Signature VARCHAR(255), Variant VARCHAR(255), Functionality VARCHAR(255), Impact VARCHAR(255), Indication VARCHAR(255), Domain VARCHAR(255), Classification VARCHAR(255), Reference VARCHAR(255))" +cursor.execute(create_table) +with open('finalrecord.csv', "r") as file: + reader = csv.reader(file) + for row in reader: + if len(row) == 10: + cursor.execute('INSERT INTO cellworksTABLE (Data,Mutation,Signature,Variant,Functionality,Impact,Indication,Domain,Classification,Reference) VALUES("%s","%s","%s","%s","%s","%s","%s","%s","%s","%s")', (row[0], row[1], row[2], row[3], row[4], row[5], row[6], row[7], row[8], row[9])) + else: + print('Error in row: ') + print(row) +database.commit() +cursor.close() + +os.remove('finalrecord.csv') diff --git a/dataonco2.py~ b/dataonco2.py~ new file mode 100644 index 0000000..4f7aefe --- /dev/null +++ b/dataonco2.py~ @@ -0,0 +1,113 @@ +import csv +import MySQLdb +from urllib import urlretrieve +import os + + +url = "http://oncokb.org/api/v1/utils/allAnnotatedVariants.txt" +urlretrieve(url,"oncotxt.txt") + +with open('oncotxt.txt', 'r') as infile, open('oncocsv.csv', 'w') as outfile: + in_txt = csv.reader(infile, delimiter = '\t') + + out_csv = csv.writer(outfile) + out_csv.writerows(in_txt) +'''with open("test.csv",'r') as f: + with open("oncocsv.csv",'w') as f1: + next(f) # skip header line + for line in f: + f1.write(line)''' + +os.remove('oncotxt.txt') + +def MapOncokb(d): + d['Database'] = 'OncoKB' + d['Mutation'] = 0 + d['Signature'] = 1 + d['Variant'] = 99999 + d['Functionality'] = 3 + d['Impact'] = 99999 + d['Indication'] = 99999 + d['Domain'] = 99999 + d['Classification'] = 99999 + d['Reference'] = 4 + + return d + +def MapFunctionality(str): + functionality = { # OncoKB map + 'Loss-of-function': 'LOF', 'Likely Loss-of-function': 'LOF', + 'Gain-of-function': 'GOF', 'Likely Gain-of-function': 'GOF', + 'Switch-of-function': 'SOF', 'Likely Switch-of-function': 'SOF', + 'Mutation Effect': 'COF', 'Likely Mutation Effect': 'COF', + 'Inconclusive': 'Inconclusive', + 'Neutral': 'Neutral', 'Likely Neutral': 'Neutral', 'null': 'NA', + # + + } + + return functionality[str.strip()] + + +def WriteDB(dbFd, dbMap, row): + + tblRow = 10*['NA'] + + tblRow[0] = dbMap['Database'] + tblRow[1] = row [dbMap['Mutation']] + tblRow[2] = row [dbMap['Signature']] + if (dbMap['Variant'] != 99999): + tblRow[3] = (row [dbMap['Variant']]) + if (dbMap['Functionality'] != 99999): + tblRow[4] = MapFunctionality (row [dbMap['Functionality']]) + if (dbMap['Impact'] != 99999): + tblRow[5] = row [dbMap['Impact']] + if (dbMap['Indication'] != 99999): + tblRow[6] = row [dbMap['Indication']] + if (dbMap['Domain'] != 99999): + tblRow[7] = row [dbMap['Domain']] + if (dbMap['Classification'] != 99999): + tblRow[8] = row [dbMap['Classification']] + if (dbMap['Reference'] != 99999): + tblRow[9] = row [dbMap['Reference']] + + return tblRow + +dbFd = 1 + +myfile = open('finalrecord.csv', 'w') +writer = csv.writer(myfile, delimiter=',') + +oncoMap = dict() +MapOncokb(oncoMap) + + +with open('oncocsv.csv', 'r') as csvFd: + reader = csv.reader(csvFd, delimiter=',') + next(reader) + for row in reader: + lin = WriteDB(dbFd, oncoMap, row) + writer.writerow(lin) +os.remove('oncocsv.csv') + + +database = MySQLdb.connect(host='localhost', user='root', passwd='root') +cursor = database.cursor() +create_database = "CREATE DATABASE IF NOT EXISTS cellworksDATA" +cursor.execute(create_database) +database = MySQLdb.connect(host='localhost', user='root', passwd='root', db='cellworksDATA') +cursor = database.cursor() +create_table = "CREATE TABLE IF NOT EXISTS cellworksTABLE (Data VARCHAR(255), Mutation VARCHAR(255), Signature VARCHAR(255), Variant VARCHAR(255), Functionality VARCHAR(255), Impact VARCHAR(255), Indication VARCHAR(255), Domain VARCHAR(255), Classification VARCHAR(255), Reference VARCHAR(255))" +cursor.execute(create_table) +with open('finalrecord.csv', "r") as file: + reader = csv.reader(file) + for row in reader: + if len(row) == 10: + cursor.execute('INSERT INTO cellworksTABLE (Data,Mutation,Signature,Variant,Functionality,Impact,Indication,Domain,Classification,Reference) VALUES("%s","%s","%s","%s","%s","%s","%s","%s","%s","%s")', (row[0], row[1], row[2], row[3], row[4], row[5], row[6], row[7], row[8], row[9])) + else: + print('Error in row: ') + print(row) +database.commit() +cursor.close() + +os.remove('finalrecord.csv') diff --git a/db_collate.py b/db_collate.py.backup similarity index 92% rename from db_collate.py rename to db_collate.py.backup index c01fd03..bf15b39 100644 --- a/db_collate.py +++ b/db_collate.py.backup @@ -2,6 +2,10 @@ # # Last Modified: Mon Aug 21 18:43:52 UTC 2017 # +<<<<<<< HEAD +import pymysql +pymysql.install_as_MySQLdb() +======= # CHANGED COLUMN #1) Mutation REQD @@ -15,6 +19,7 @@ #9) Reference REQD +>>>>>>> 263188128c53dc04d84901795fdda53d7dcdf0bf import csv import MySQLdb @@ -238,6 +243,12 @@ def FilterRow(row): dbFd = 1 # stdout will be the 'DB' for now. +<<<<<<< HEAD +myfile = open('final_record.csv', 'w') +writer = csv.writer(myfile, delimiter=',') + + +======= # final_record.csv will store data from all the databases into # one CSV. dbfd = open('final_record.csv', 'wb+') @@ -253,9 +264,10 @@ def FilterRow(row): print 'processing oncoKB' +>>>>>>> 263188128c53dc04d84901795fdda53d7dcdf0bf oncoMap = dict(); MapOncokb(oncoMap) -with open('oncoKB_tmp.csv', 'rb') as csvFd: +with open('oncoKB_tmp.csv', 'r') as csvFd: reader = csv.reader(csvFd, delimiter='\t') for row in reader: lin = FormatRow(dbFd, oncoMap, row) @@ -265,7 +277,7 @@ def FilterRow(row): print 'processing Civic' civicMap = dict() MapCivic(civicMap) -with open('civic_tmp.csv', 'rb') as csvFd: +with open('civic_tmp.csv', 'r') as csvFd: reader = csv.reader(csvFd, delimiter='\t') for row in reader: lin = FormatRow(dbFd, civicMap, row) @@ -276,7 +288,7 @@ def FilterRow(row): print 'processing Synapse' synapseMap = dict() MapSynapse(synapseMap) -with open('synapse_tmp.csv', 'rb') as csvFd: +with open('synapse_tmp.csv', 'r') as csvFd: reader = csv.reader(csvFd, delimiter=',') for row in reader: lin = FormatRow(dbFd, synapseMap, row) @@ -287,18 +299,24 @@ def FilterRow(row): print 'processing docm' docmMap = dict() MapDocm(docmMap) -with open('docm_tmp.tsv', 'rb') as csvFd: +with open('docm_tmp.tsv', 'r') as csvFd: reader = csv.reader(csvFd, delimiter='\t') for row in reader: +<<<<<<< HEAD + lin = WriteDB(dbFd, docmMap, row) + writer.writerow(lin) + +======= lin = FormatRow(dbFd, docmMap, row) db_writer.writerow(lin) if FilterRow(lin): filter_writer.writerow(lin) +>>>>>>> 263188128c53dc04d84901795fdda53d7dcdf0bf print 'processing Candl' candlMap = dict() MapCandl(candlMap) -with open('candl_tmp.csv', 'rb') as csvFd: +with open('candl_tmp.csv', 'r') as csvFd: reader = csv.reader(csvFd, delimiter=',') for row in reader: if len(row) < 10: @@ -316,7 +334,7 @@ def FilterRow(row): #Store final data in mysql database. -db_conn = MySQLdb.connect(host='localhost', user='drupal', passwd='drupal123') +db_conn = MySQLdb.connect(host='localhost', user='root', passwd='root') cur = db_conn.cursor() # NOTE: Combining multiple statements and executing at one go with cur.execute() @@ -342,11 +360,20 @@ def FilterRow(row): cur.execute(qry) +<<<<<<< HEAD + +file = open('final_record.csv', "r") +======= file = open('final_record.csv', "rb") +>>>>>>> 263188128c53dc04d84901795fdda53d7dcdf0bf reader = csv.reader(file) next(reader, None) # Skipping header for row in reader: +<<<<<<< HEAD + +======= +>>>>>>> 263188128c53dc04d84901795fdda53d7dcdf0bf if len(row) == 10: cur.execute('''INSERT INTO final_data (Source, Mutation,Signature, Variant,Functionality,Impact, Indication,Domain, @@ -354,8 +381,8 @@ def FilterRow(row): VALUES("%s","%s","%s","%s","%s","%s","%s","%s","%s","%s")''', (row[0], row[1], row[2], row[3], row[4], row[5], row[6], row[7], row[8], row[9])) else: - print "db_collate: Error in row len, not written to DB" - print row + print("db_collate: Error in row len, not written to DB") + print(row) db_conn.commit() cur.close() diff --git a/db_collate.py~ b/db_collate.py~ new file mode 100644 index 0000000..b7728d7 --- /dev/null +++ b/db_collate.py~ @@ -0,0 +1,280 @@ +# db_collate.py -- Collate Oncokb, synapse, civic and docm gene databases +# +# Last Modified: Mon Aug 21 18:43:52 UTC 2017 +# + +import csv +import MySQLdb + + +# In docm sig, simply need to remove the 'p.' prefix +# Ex: p.E2419K => E2419K +# +def MapDocmSignature (pos, row): + col = row[pos[0]] + return col[2:] + +# Use variants.tsv +def MapDocm(d): + d['Database'] = 'Docm' + d['Mutation'] = 7 + d['Signature'] = [MapDocmSignature, 9] # IMPT: Remove the "p." + d['Variant'] = 99999 + d['Functionality'] = 99999 + d['Impact'] = 99999 + d['Indication'] = 99999 + d['Domain'] = 99999 + d['Classification'] = 99999 + d['Reference'] = 11 + + return d + + + +# Candl sign is a concate of row C,D,E +# + +def MapCandlSignature(lst,row): + sig = row[lst[0]] + row[lst[1]] + row[lst[2]] + return sig + +# Use candl +def MapCandl(d): + d['Database'] = 'Candl' + d['Mutation'] = 1 + d['Signature'] = [MapCandlSignature, 2,3,4] # Concatination of Columns C, D & E + d['Variant'] = 99999 + d['Functionality'] = 99999 + d['Impact'] = 99999 + d['Indication'] = 99999 + d['Domain'] = 99999 + d['Classification'] = 99999 + d['Reference'] = 15 # TODO Column 'P' + + return d + + + +# Index of each field in OncoKB mapped to standard table fmt. +# +def MapOncokb(d): + d['Database'] = 'OncoKB' + d['Mutation'] = 0 + d['Signature'] = 2 # BUG: Remove Truncating Mutation, Promoter Mutation + d['Variant'] = 99999 + d['Functionality'] = 3 + d['Impact'] = 99999 + d['Indication'] = 99999 + d['Domain'] = 99999 + d['Classification'] = 99999 + d['Reference'] = 4 + + return d + +# Index of each field in Civic DB mapped to standard table fmt. +# +def MapCivic(d): + d['Database'] = 'Civic' + d['Mutation'] = 0 + d['Signature'] = 2 + d['Variant'] = 3 + d['Functionality'] = 99999 + d['Impact'] = 99999 + d['Indication'] = 3 # Changed; mapped to 'Disease' + d['Domain'] = 99999 + d['Classification'] = 99999 + d['Reference'] = 11 + + return d + + +# Synapse reference field has multiple columns with PMID's. +# Collect PMID's from all columns +# Params: +# lst: List of columns to pick up PMID's +# row: CSV row +# +def MapSynapseReference (lst, row): + refs = '' + for pos in lst: + refs = refs + ',' + row[pos] + + return refs + + + +# # Index of each field in Synapse DB mapped to standard table fmt. +# # +def MapSynapse(d): + d['Database'] = 'Synapse' + d['Mutation'] = 1 # TODO: "Few mutations have multiple signatures in same cell like + # ABL1 F317L/V/I/C, this means ABL1 has four signatures which are + # F317L, F317V, F317I, F317C. These need to be in different rows" + d['Signature'] = 2 + d['Variant'] = 99999 # 3 + d['Functionality'] = 4 + d['Impact'] = 99999 + d['Indication'] = 99999 # DISEASE (Column 1) + d['Domain'] = 99999 + d['Classification'] = 99999 + d['Reference'] = [MapSynapseReference, 9,14,19,24,29,38,43] # PMID cols: J,O,T,Y,AD,AN,AS + + return d + + + +# Standardise fuctionality to LOF, GOF, etc in the various DB's +def MapFunctionality(str): + functionality = { # OncoKB map + 'Loss-of-function': 'LOF', 'Likely Loss-of-function': 'Likely LOF', + 'Gain-of-function': 'GOF', 'Likely Gain-of-function': 'Likely GOF', + 'Switch-of-function': 'SOF', 'Likely Switch-of-function': 'Likely SOF', + 'Mutation Effect': 'COF', 'Likely Mutation Effect': 'Likely COF', + 'Inconclusive': 'Inconclusive', + 'Neutral': 'COF', 'Likely Neutral': 'COF', + # + #synapse + 'gain-of-function': 'GOF', 'gain-of-function (low activity)': 'GOF', + 'loss-of-function' : 'LOF', 'switch-of-function': 'SOF', + 'reduced kinase activity':'LOF', + 'not applicable': 'NA', + # + } + + return functionality[str.strip()] + + + + +# Copy over the row from CSV to standard fmt and then write it out. +# Note: Currently simply writes to stdout. +# +def WriteDB(dbFd, dbMap, row): + tblRow = 10*['NA'] + + tblRow[0] = dbMap['Database'] + tblRow[1] = row [dbMap['Mutation']] + if isinstance (dbMap['Signature'], list): + tblRow[2] = dbMap['Signature'][0] (dbMap['Signature'][1:], row) + else: + tblRow[2] = (row [dbMap['Signature']]) + if (dbMap['Variant'] != 99999): + tblRow[3] = (row [dbMap['Variant']]) + if (dbMap['Functionality'] != 99999): + tblRow[4] = MapFunctionality (row [dbMap['Functionality']]) + if (dbMap['Impact'] != 99999): + tblRow[5] = row [dbMap['Impact']] + if (dbMap['Indication'] != 99999): + tblRow[6] = row [dbMap['Indication']] + if (dbMap['Domain'] != 99999): + tblRow[7] = row [dbMap['Domain']] + if (dbMap['Classification'] != 99999): + tblRow[8] = row [dbMap['Classification']] + if isinstance(dbMap['Reference'], list): + tblRow[9] = dbMap['Reference'][0] (dbMap['Reference'][1:], row) + elif (dbMap['Reference'] != 99999): + tblRow[9] = row [dbMap['Reference']] + + return tblRow + + + +## main() + +dbFd = 1 # stdout will be the 'DB' for now. + +myfile = open('final_record.csv', 'wb+') +writer = csv.writer(myfile, delimiter=',') + + +oncoMap = dict(); +MapOncokb(oncoMap) +with open('oncoKB_tmp.csv', 'rb') as csvFd: + reader = csv.reader(csvFd, delimiter='\t') + for row in reader: + lin = WriteDB(dbFd, oncoMap, row) + writer.writerow(lin) + +civicMap = dict() +MapCivic(civicMap) +with open('civic_tmp.csv', 'rb') as csvFd: + reader = csv.reader(csvFd, delimiter='\t') + for row in reader: + lin = WriteDB(dbFd, civicMap, row) + writer.writerow(lin) + +synapseMap = dict() +MapSynapse(synapseMap) +with open('synapse_tmp.csv', 'rb') as csvFd: + reader = csv.reader(csvFd, delimiter=',') + for row in reader: + lin = WriteDB(dbFd, synapseMap, row) + writer.writerow(lin) + +docmMap = dict() +MapDocm(docmMap) +with open('docm_tmp.tsv', 'rb') as csvFd: + reader = csv.reader(csvFd, delimiter='\t') + for row in reader: + lin = WriteDB(dbFd, docmMap, row) + writer.writerow(lin) + + +candlMap = dict() +MapCandl(candlMap) +with open('candl_tmp.csv', 'rb') as csvFd: + reader = csv.reader(csvFd, delimiter=',') + for row in reader: + lin = WriteDB(dbFd, candlMap, row) + writer.writerow(lin) + +myfile.close() + +#Store final data in mysql database. + +db_conn = MySQLdb.connect(host='localhost', user='root', passwd='root') +cur = db_conn.cursor() + +# NOTE: Combining multiple statements and executing at one go with cur.execute() +# fails with "ProgrammingError: (2014, "Commands out of sync; you can't run this command now") Error. +# Something to do with MySQL not able to handle multiple queries at one go. +qry = 'USE cellworks;' +cur.execute(qry) +qry = 'DROP TABLE IF EXISTS final_data' +cur.execute(qry) +qry = ''' +CREATE TABLE final_data ( + Source VARCHAR(255), + Mutation VARCHAR(255), + Signature VARCHAR(255), + Variant VARCHAR(255), + Functionality VARCHAR(255), + Impact VARCHAR(255), + Indication VARCHAR(255), + Domain VARCHAR(255), + Classification VARCHAR(255), + Reference VARCHAR(255)); +''' + +cur.execute(qry) + + +file = open('final_record.csv', "rb") +reader = csv.reader(file) +for row in reader: + + if len(row) == 10: + cur.execute('''INSERT INTO final_data (Source, Mutation,Signature, + Variant,Functionality,Impact, Indication,Domain, + Classification,Reference) + VALUES("%s","%s","%s","%s","%s","%s","%s","%s","%s","%s")''', + (row[0], row[1], row[2], row[3], row[4], row[5], row[6], row[7], row[8], row[9])) + else: + print "db_collate: Error in row len, not written to DB" + print row + + #print row +db_conn.commit() +cur.close() + + diff --git a/db_get.py b/db_get.py new file mode 100644 index 0000000..237a1fe --- /dev/null +++ b/db_get.py @@ -0,0 +1,25 @@ +#db_get.py -- get all Databases from URLs and write the CSV into /tmp/DB_name +# + +import csv +import MySQLdb +from urllib import urlretrieve +import os + + +onco_url = "http://oncokb.org/api/v1/utils/allAnnotatedVariants.txt" +print 'retrieving from' + onco_url +urlretrieve(onco_url,"/tmp/oncotxt.txt") + +civic_url = "https://civic.genome.wustl.edu/downloads/nightly/nightly-ClinicalEvidenceSummaries.tsv" +print 'retrieving from' +civic_url +urlretrieve(civic_url, "/tmp/civic.tsv") + +Synapse_url = 'https://www.synapse.org/Portal/filehandle?entityId=syn2653551&preview=false&proxy=false&xsrfToken=F7228553D367BBB7C8CE655512E8AC5D&version=1' +values = {'username': 'soumya.s@gai.co.in', + 'password': 'GAIcellworks'} +r = requests.post(url, data=values) +print 'retrieving from' + Synapse_url +urlretrieve(synapse_url,"/tmp/synapse.xls") + + diff --git a/docm_tmp.tsv b/docm_tmp.tsv new file mode 100644 index 0000000..6f3ce5a --- /dev/null +++ b/docm_tmp.tsv @@ -0,0 +1,7 @@ +ENST00000361445:c.7500T>G 1 11169375 11169375 A C GRCh37 MTOR missense p.I2500M renal clear cell carcinoma,gastric adenocarcinoma,breast cancer,uterine corpus endometrial carcinoma 26619011 +ENST00000361445:c.4449C>G 1 11217229 11217229 G C GRCh37 MTOR missense p.C1483W renal clear cell carcinoma,glioblastoma multiforme,breast cancer 26619011 +ENST00000369535:c.182A>G 1 115256529 115256529 T C GRCh37 NRAS missense p.Q61R acute myeloid leukemia,urinary bladder urothelial carcinoma,thyroid cancer,non-small cell lung carcinoma,melanoma,colorectal cancer,brain glioma,gastric adenocarcinoma,uterine corpus endometrial carcinoma,chronic lymphocytic leukemia,skin melanoma,lung adenocarcinoma,ovarian serous cystadenocarcinoma,chromophobe adenocarcinoma,thyroid carcinoma,nasopharynx carcinoma,glioblastoma multiforme,multiple myeloma,adrenocortical carcinoma,hepatocellular carcinoma 19075190,16434492,26619011,19773371,23515407,2674680,21305640,2278970,19255327,22761467,21107323,23406027,20619739,20130576,21729679,23614898,3122217,18390968,18948947,8120410,23538902,16273091,25157968,17384584,20736745,20179705,17699718,23569304,21829508,16291983,21576590,12460918,22407852,23414587 +ENST00000369535:c.182A>C 1 115256529 115256529 T G GRCh37 NRAS missense p.Q61P nasopharynx carcinoma,brain glioma,urinary bladder urothelial carcinoma,thyroid carcinoma,melanoma,adrenocortical carcinoma,non-small cell lung carcinoma,chronic lymphocytic leukemia,skin melanoma,glioblastoma multiforme,multiple myeloma,acute myeloid leukemia,chromophobe adenocarcinoma,hepatocellular carcinoma,colorectal cancer,gastric adenocarcinoma,lung adenocarcinoma,ovarian serous cystadenocarcinoma,uterine corpus endometrial carcinoma 26619011,23414587,23569304,23614898,24370118,8120410,20130576,22761467,18390968,23538902,2674680,20179705,25157968,16291983 +ENST00000369535:c.181C>T 1 115256530 115256530 G A GRCh37 NRAS stop_lost p.Q61* melanoma 23076151,25157968 +ENST00000369535:c.181C>A 1 115256530 115256530 G T GRCh37 NRAS missense p.Q61K ovarian serous cystadenocarcinoma,melanoma,colorectal cancer,skin melanoma,chromophobe adenocarcinoma,thyroid cancer,brain glioma,lung adenocarcinoma,thyroid carcinoma,nasopharynx carcinoma,chronic lymphocytic leukemia,multiple myeloma,non-small cell lung carcinoma,adrenocortical carcinoma,uterine corpus endometrial carcinoma,acute myeloid leukemia,neuroblastoma,hepatocellular carcinoma,glioblastoma multiforme,gastric adenocarcinoma,urinary bladder urothelial carcinoma 26619011,23414587,18390968,21829508,16273091,2674680,20619739,21305640,19255327,19773371,23614898,17384584,8120410,20130576,20736745,21729679,18948947,12460918,22761467,23538902,26821351,23515407,17699718,23569304,16291983,21107323,23406027,20179705,19657110 +ENST00000349496:c.64delGTTAGTCACTGGCAGCAACAGTCTTACCTGGACTCTGGAATCCATTCTGGT 3 41266067 41266117 GTTAGTCACTGGCAGCAACAGTCTTACCTGGACTCTGGAATCCATTCTGGT - GRCh37 CTNNB1 inframe p.VSHWQQQSYLDSGIHSG22- melanoma 25157968 diff --git a/final_record.csv b/final_record.csv new file mode 100644 index 0000000..1f34c34 --- /dev/null +++ b/final_record.csv @@ -0,0 +1,6417 @@ +OncoKB,FAM58A,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"24218572, 18297069" +OncoKB,CBL,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,"20126411, 26676746" +OncoKB,CBL,Likely Neutral,NA,COF,NA,NA,NA,NA,26676746 +OncoKB,CBL,Oncogenic,NA,LOF,NA,NA,NA,NA,"25178484, 17446348, 19387008, 19734451" +OncoKB,CBL,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,26676746 +OncoKB,CBL,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"19276253, 19901108, 22315494" +OncoKB,CBL,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,20126411 +OncoKB,CBL,Oncogenic,NA,LOF,NA,NA,NA,NA,"23696637, 26676746" +OncoKB,CBL,Likely Neutral,NA,COF,NA,NA,NA,NA,26676746 +OncoKB,CBL,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,19387008 +OncoKB,CBL,Oncogenic,NA,LOF,NA,NA,NA,NA,19620960 +OncoKB,CBL,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,"25178484, 26676746" +OncoKB,CBL,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"20508043, 20694012, 22315494" +OncoKB,CBL,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,19387008 +OncoKB,CBL,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,19387008 +OncoKB,CBL,Likely Neutral,NA,COF,NA,NA,NA,NA,26676746 +OncoKB,CBL,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,"25178484, 26676746" +OncoKB,CBL,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,26676746 +OncoKB,CBL,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,"20126411, 26676746" +OncoKB,CBL,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,26676746 +OncoKB,CBL,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,26676746 +OncoKB,CBL,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,26676746 +OncoKB,CBL,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,25178484 +OncoKB,CBL,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,26676746 +OncoKB,CBL,Oncogenic,NA,LOF,NA,NA,NA,NA,23696637 +OncoKB,CBL,Oncogenic,NA,LOF,NA,NA,NA,NA,19620960 +OncoKB,CBL,Likely Neutral,NA,COF,NA,NA,NA,NA,19387008 +OncoKB,CBL,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,20126411 +OncoKB,SHOC2,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,25137548 +OncoKB,SHOC2,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,"19684605, 23918763" +OncoKB,TERT,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,18042801 +OncoKB,TERT,Oncogenic,NA,GOF,NA,NA,NA,NA,"23348506, 23348503, 23887589, 24657534, 25048572, 23530248" +OncoKB,TERT,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,18042801 +OncoKB,TERT,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,18042801 +OncoKB,TERT,Oncogenic,NA,GOF,NA,NA,NA,NA,"23348506, 23348503, 23887589, 26389665, 24657534, 23530248" +OncoKB,TERT,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"25219713, 18482052, 25301727" +OncoKB,TERT,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,18042801 +OncoKB,TERT,Oncogenic,NA,GOF,NA,NA,NA,NA,"23348506, 23348503, 23887589, 24657534, 23530248" +OncoKB,DICER1,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,22187960 +OncoKB,DICER1,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,17920623 +OncoKB,DICER1,Oncogenic,NA,LOF,NA,NA,NA,NA,"26033159, 22187960" +OncoKB,DICER1,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,22187960 +OncoKB,DICER1,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"20305640, 22133720, 21501861, 22353998, 21266384" +OncoKB,DICER1,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,22187960 +OncoKB,DICER1,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,17920623 +OncoKB,DICER1,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,26033159 +OncoKB,DICER1,Oncogenic,NA,LOF,NA,NA,NA,NA,26033159 +OncoKB,DICER1,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"20305640, 26513514, 27295554, 19903759, 22353998" +OncoKB,PTPRT,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,24493670 +OncoKB,PTPRT,Oncogenic,NA,LOF,NA,NA,NA,NA,24395800 +OncoKB,PTPRT,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,15155950 +OncoKB,PTPRT,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,20230342 +OncoKB,PTPRT,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,"15155950, 22389709" +OncoKB,PTPRT,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,"15155950, 22389709" +OncoKB,PTPRT,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,20230342 +OncoKB,PTPRT,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,18644975 +OncoKB,PTPRT,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,20230342 +OncoKB,PTPRT,Oncogenic,NA,Likely LOF,NA,NA,NA,NA,24395800 +OncoKB,PTPRT,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,18644975 +OncoKB,PTPRT,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"15155950, 18644975" +OncoKB,PTPRT,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,20230342 +OncoKB,PTPRT,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,20230342 +OncoKB,PTPRT,Oncogenic,NA,LOF,NA,NA,NA,NA,"25009298, 25982282, 23096495" +OncoKB,PTPRT,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,20230342 +OncoKB,PTPRT,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,20230342 +OncoKB,PTPRT,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,15155950 +OncoKB,PTPRT,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,18644975 +OncoKB,PTPRT,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,20230342 +OncoKB,PTPRT,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,"24317090, 17360477" +OncoKB,PTPRT,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"15155950, 20133777, 21517784" +OncoKB,PTPRT,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,18644975 +OncoKB,PTPRT,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,20230342 +OncoKB,PTPRT,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,15155950 +OncoKB,PTPRT,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,22389709 +OncoKB,RHEB,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,"24631838, 22819219" +OncoKB,RHEB,Oncogenic,NA,GOF,NA,NA,NA,NA,"24631838, 22819219" +OncoKB,RHEB,Oncogenic,NA,GOF,NA,NA,NA,NA,"24631838, 27399332, 22819219, 26255626" +OncoKB,SHQ1,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"19383767, 19019820, 20579941" +OncoKB,SHQ1,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA, +OncoKB,CCND2,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,8114739 +OncoKB,RAD50,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"16474176, 14684699, 16385572" +OncoKB,RAD50,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"12208847, 2659437, 14684699, 15309560" +OncoKB,RAD50,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,24934408 +OncoKB,RAD50,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"12208847, 16288216, 21892167, 14684699" +OncoKB,CCND3,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,8114739 +OncoKB,CCND3,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,9832503 +OncoKB,CCND3,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"2876518, 24913233, 22885699" +OncoKB,CCND3,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,"2876518, 24913233, 22885699" +OncoKB,CCND3,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,9832503 +OncoKB,CCND3,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,9832503 +OncoKB,CCND3,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"2876518, 24913233, 22885699" +OncoKB,CCND3,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,"2876518, 24913233, 22885699" +OncoKB,RIT1,Oncogenic,NA,GOF,NA,NA,NA,NA,24469055 +OncoKB,RIT1,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,26714497 +OncoKB,RIT1,Oncogenic,NA,GOF,NA,NA,NA,NA,24469055 +OncoKB,RIT1,Oncogenic,NA,GOF,NA,NA,NA,NA,24469055 +OncoKB,CCNE1,Oncogenic,NA,GOF,NA,NA,NA,NA,"8618861, 15838514, 12845634, 24605326" +OncoKB,CCNE1,Oncogenic,NA,GOF,NA,NA,NA,NA,"8618861, 15838514, 12845634, 24605326" +OncoKB,RYBP,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,19098711 +OncoKB,TGFBR1,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,21358634 +OncoKB,TGFBR1,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,"21358634, 23358096" +OncoKB,TGFBR1,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"16928994, 25116393, 16791849" +OncoKB,TGFBR1,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,16791849 +OncoKB,TGFBR1,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,"21358634, 23358096" +OncoKB,TGFBR1,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"10656986, 11212236" +OncoKB,TGFBR1,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,9809982 +OncoKB,TGFBR1,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,21358634 +OncoKB,TGFBR1,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,"17848956, 10582683, 20429896, 16204663, 19882361, 22905183" +OncoKB,TGFBR2,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,18339844 +OncoKB,TGFBR2,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,7862150 +OncoKB,TGFBR2,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,8668164 +OncoKB,TGFBR2,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"27558455, 25521327, 25736321" +OncoKB,TGFBR2,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,"18339844, 10789724" +OncoKB,TGFBR2,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"16310402, 17456004, 17985359, 9927040, 11309634, 7585632" +OncoKB,MSH6,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"11709755, 24362816, 22102614, 23621914" +OncoKB,MSH6,Likely Neutral,NA,COF,NA,NA,NA,NA,21120944 +OncoKB,MSH6,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"21056691, 19072991" +OncoKB,MSH6,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"25255306, 24090359, 21970482, 12019211, 22781090" +OncoKB,MSH6,Oncogenic,NA,LOF,NA,NA,NA,NA,"9808525, 11474654, 19254532, 9331106" +OncoKB,MSH6,Likely Neutral,NA,COF,NA,NA,NA,NA,"22581703, 24040339, 12522549, 23621914" +OncoKB,MSH6,Oncogenic,NA,LOF,NA,NA,NA,NA,"12732731, 11474654, 10959092, 9510473, 19254532, 21637783" +OncoKB,MSH6,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"9822680, 9111312, 1651234, 9564049" +OncoKB,MSH6,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"11709755, 24362816, 11807791, 18790734" +OncoKB,MSH6,Likely Neutral,NA,COF,NA,NA,NA,NA,24362816 +OncoKB,MSH6,Oncogenic,NA,LOF,NA,NA,NA,NA,"24362816, 19254532" +OncoKB,MSH6,Oncogenic,NA,LOF,NA,NA,NA,NA,"12732731, 22810696, 19254532" +OncoKB,MSH6,Oncogenic,NA,LOF,NA,NA,NA,NA,"24755471, 22810696, 19254532" +OncoKB,MSH6,Likely Neutral,NA,COF,NA,NA,NA,NA,24362816 +OncoKB,KMT2D,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"24633898, 24240169, 26366712" +OncoKB,KMT2D,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"24633898, 24240169, 26366712" +OncoKB,LATS1,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,"9988269, 23230145, 11850843" +OncoKB,LATS1,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"9988269, 23573293, 26040669" +OncoKB,PBRM1,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"18339845, 21248752, 23867514, 22949125" +OncoKB,PBRM1,Oncogenic,NA,LOF,NA,NA,NA,NA,25911086 +OncoKB,PBRM1,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"18339845, 24613357, 21248752, 22949125, 21654818" +OncoKB,SF3B1,Likely Oncogenic,NA,SOF,NA,NA,NA,NA,25428262 +OncoKB,SF3B1,Likely Oncogenic,NA,SOF,NA,NA,NA,NA,24434863 +OncoKB,SF3B1,Likely Oncogenic,NA,SOF,NA,NA,NA,NA,"24434863, 25428262, 21909114" +OncoKB,SF3B1,Likely Oncogenic,NA,SOF,NA,NA,NA,NA,"25788694, 26565915" +OncoKB,SF3B1,Likely Oncogenic,NA,SOF,NA,NA,NA,NA,24434863 +OncoKB,SF3B1,Likely Oncogenic,NA,SOF,NA,NA,NA,NA,"24434863, 26565915, 23861464" +OncoKB,SF3B1,Oncogenic,NA,SOF,NA,NA,NA,NA,"25428262, 21909114" +OncoKB,SF3B1,Likely Oncogenic,NA,SOF,NA,NA,NA,NA,23160465 +OncoKB,SF3B1,Likely Oncogenic,NA,Likely SOF,NA,NA,NA,NA,"24434863, 26565915, 26619011, 25428262" +OncoKB,SF3B1,Likely Oncogenic,NA,SOF,NA,NA,NA,NA,"24434863, 26565915, 23861464" +OncoKB,SF3B1,Likely Oncogenic,NA,SOF,NA,NA,NA,NA,"25428262, 21909114" +OncoKB,SF3B1,Likely Oncogenic,NA,SOF,NA,NA,NA,NA,"24434863, 26565915, 23861464" +OncoKB,SF3B1,Likely Oncogenic,NA,SOF,NA,NA,NA,NA,"25424858, 24434863, 26565915, 24854990, 23335386, 25428262, 23160465, 27622333, 21909114" +OncoKB,SF3B1,Likely Oncogenic,NA,SOF,NA,NA,NA,NA,"26565915, 25428262, 21909114" +OncoKB,SF3B1,Likely Oncogenic,NA,SOF,NA,NA,NA,NA,"24434863, 25788694" +OncoKB,SF3B1,Likely Oncogenic,NA,SOF,NA,NA,NA,NA,"25428262, 21909114" +OncoKB,SF3B1,Likely Oncogenic,NA,SOF,NA,NA,NA,NA,"25428262, 21909114" +OncoKB,SF3B1,Likely Oncogenic,NA,SOF,NA,NA,NA,NA,"24434863, 26842708" +OncoKB,LATS2,Oncogenic,NA,LOF,NA,NA,NA,NA,21245096 +OncoKB,EGFR,Oncogenic,NA,GOF,NA,NA,NA,NA,"23371856, 19536777, 24353160, 21764376, 18676761, 15897572, 17686547, 17192902" +OncoKB,EGFR,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,19020901 +OncoKB,EGFR,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"22760226, 15897572" +OncoKB,EGFR,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,"20522446, 21531810, 19147750, 21841502" +OncoKB,EGFR,Oncogenic,NA,GOF,NA,NA,NA,NA,"21422421, 22190593" +OncoKB,EGFR,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,24743239 +OncoKB,EGFR,Oncogenic,NA,GOF,NA,NA,NA,NA,"15329413, 18000506, 15118125, 19536777, 18458038, 15118073, 22019513, 23566546, 23559152, 24457318, 22760226, 23749122, 17192902" +OncoKB,EGFR,Oncogenic,NA,GOF,NA,NA,NA,NA,"23371856, 19536777, 24353160, 21764376, 18676761, 15897572, 21841502, 17686547" +OncoKB,EGFR,Oncogenic,NA,GOF,NA,NA,NA,NA,"15118073, 15329413, 25179728, 15118125" +OncoKB,EGFR,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,23912954 +OncoKB,EGFR,Oncogenic,NA,GOF,NA,NA,NA,NA,24353160 +OncoKB,EGFR,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,18000506 +OncoKB,EGFR,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,18000506 +OncoKB,EGFR,Oncogenic,NA,GOF,NA,NA,NA,NA,"16407879, 19015641" +OncoKB,EGFR,Oncogenic,NA,GOF,NA,NA,NA,NA,"15728811, 18227510, 15737014" +OncoKB,EGFR,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,18193092 +OncoKB,EGFR,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"23242437, 22190593" +OncoKB,EGFR,Oncogenic,NA,GOF,NA,NA,NA,NA,17974985 +OncoKB,EGFR,Likely Neutral,NA,Likely LOF,NA,NA,NA,NA,18193092 +OncoKB,EGFR,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"16467085, 18000506" +OncoKB,EGFR,Oncogenic,NA,GOF,NA,NA,NA,NA,"23371856, 19536777, 24353160, 21764376, 18676761, 23749122, 15897572, 17686547" +OncoKB,EGFR,Likely Neutral,NA,COF,NA,NA,NA,NA,"19671738, 21841502" +OncoKB,EGFR,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"22483783, 18000506" +OncoKB,EGFR,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,25232377 +OncoKB,EGFR,Oncogenic,NA,GOF,NA,NA,NA,NA,"24120142, 17177598" +OncoKB,EGFR,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,16467085 +OncoKB,EGFR,Oncogenic,NA,GOF,NA,NA,NA,NA,"16467085, 15118073, 15329413, 25179728, 15118125" +OncoKB,EGFR,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"19671738, 15897572" +OncoKB,EGFR,Oncogenic,NA,GOF,NA,NA,NA,NA,"15118073, 15329413, 21841502, 15118125" +OncoKB,EGFR,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,18000506 +OncoKB,EGFR,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,20942962 +OncoKB,EGFR,Oncogenic,NA,GOF,NA,NA,NA,NA,"15118073, 15329413, 18261621, 15118125" +OncoKB,EGFR,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,25633215 +OncoKB,EGFR,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,21531810 +OncoKB,EGFR,Likely Neutral,NA,Inconclusive,NA,NA,NA,NA,19020901 +OncoKB,EGFR,Oncogenic,NA,GOF,NA,NA,NA,NA,24353160 +OncoKB,EGFR,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"16467085, 16106023, 25130612, 24934779" +OncoKB,EGFR,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"21531810, 19147750" +OncoKB,EGFR,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"23371856, 19536777, 24353160, 21764376, 18676761, 15897572, 17686547, 17192902" +OncoKB,EGFR,Oncogenic,NA,GOF,NA,NA,NA,NA,"15118073, 15329413, 15118125, 17192902" +OncoKB,EGFR,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"21531810, 19536777, 26051236" +OncoKB,EGFR,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,26416732 +OncoKB,EGFR,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"21531810, 19536777, 19147750, 17177598, 26051236, 21252719" +OncoKB,EGFR,Oncogenic,NA,GOF,NA,NA,NA,NA,"19536777, 16205628, 25521406, 25521405, 23242437, 19147750, 18676761, 23912954, 25179728, 25130612" +OncoKB,EGFR,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"21531810, 26051236, 23912954" +OncoKB,EGFR,Oncogenic,NA,GOF,NA,NA,NA,NA,"18325048, 23242437, 15118073, 15329413, 23387505, 15897572, 15118125" +OncoKB,EGFR,Likely Neutral,NA,LOF,NA,NA,NA,NA,19147750 +OncoKB,EGFR,Oncogenic,NA,GOF,NA,NA,NA,NA,"16467085, 15118073, 15329413, 15118125, 17192902" +OncoKB,EGFR,Oncogenic,NA,GOF,NA,NA,NA,NA,"21531810, 16187797, 26206867" +OncoKB,EGFR,Oncogenic,NA,GOF,NA,NA,NA,NA,"23371856, 19536777, 24353160, 21764376, 18676761, 23912954, 23749122, 15897572, 17686547" +OncoKB,EGFR,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"21531810, 17177598, 18000506" +OncoKB,EGFR,Oncogenic,NA,GOF,NA,NA,NA,NA,"15118073, 15329413, 15118125" +OncoKB,EGFR,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,21531810 +OncoKB,EGFR,Oncogenic,NA,GOF,NA,NA,NA,NA,"21531810, 18508816, 19536777, 26339441, 26001153, 22190593" +OncoKB,EGFR,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"27102076, 23917401" +OncoKB,EGFR,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,"19147750, 26870223" +OncoKB,EGFR,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,25633215 +OncoKB,EGFR,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,26416732 +OncoKB,EGFR,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,20942962 +OncoKB,EGFR,Oncogenic,NA,GOF,NA,NA,NA,NA,"15118073, 15329413, 22483783, 25179728, 15710947, 15118125" +OncoKB,EGFR,Oncogenic,NA,GOF,NA,NA,NA,NA,24212795 +OncoKB,EGFR,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,20942962 +OncoKB,EGFR,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,24743239 +OncoKB,EGFR,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"17973572, 17545553, 19632948, 17085664, 17192902" +OncoKB,EGFR,Oncogenic,NA,GOF,NA,NA,NA,NA,"17189397, 1730638, 2790960" +OncoKB,EGFR,Oncogenic,NA,GOF,NA,NA,NA,NA,"8895767, 17189397, 19324552, 8052651, 23777544, 12438278" +OncoKB,EGFR,Oncogenic,NA,GOF,NA,NA,NA,NA,"21531810, 18508816, 16467085, 17177598, 25668120, 21841502, 15897572, 21252719, 19536777, 18325048, 19147750, 26051236, 18676761, 23912954, 24457318, 22760226, 20808254, 23749122, 24285021" +OncoKB,EGFR,Oncogenic,NA,GOF,NA,NA,NA,NA,"23371856, 19536777, 24353160, 21764376, 18676761, 25179728, 15897572, 17686547" +OncoKB,EGFR,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"21531810, 15118073, 19147750, 18261621, 26206867, 21841502" +OncoKB,EGFR,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"23371856, 19536777, 24353160, 21764376, 18676761, 15897572, 17686547" +OncoKB,EGFR,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,21531810 +OncoKB,EGFR,Oncogenic,NA,GOF,NA,NA,NA,NA,27216155 +OncoKB,EGFR,Oncogenic,NA,GOF,NA,NA,NA,NA,"18193092, 25435280" +OncoKB,EGFR,Oncogenic,NA,GOF,NA,NA,NA,NA,"23371856, 19536777, 24353160, 21764376, 18676761, 15897572, 21841502, 17686547" +OncoKB,EGFR,Oncogenic,NA,GOF,NA,NA,NA,NA,"23371856, 19536777, 24353160, 21764376, 18676761, 23749122, 15897572, 17686547" +OncoKB,EGFR,Oncogenic,NA,GOF,NA,NA,NA,NA,"24893890, 17189397" +OncoKB,EGFR,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,19147750 +OncoKB,EGFR,Oncogenic,NA,GOF,NA,NA,NA,NA,"21531810, 17177598, 24743239, 21841502, 21252719" +OncoKB,EGFR,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,"23242437, 20512075, 23358982" +OncoKB,EGFR,Oncogenic,NA,GOF,NA,NA,NA,NA,"15118073, 15329413, 15710947, 15118125" +OncoKB,EGFR,Oncogenic,NA,GOF,NA,NA,NA,NA,"18508816, 18325048, 16467085, 15118073, 15329413, 18261621, 22483783, 25179728, 16373402, 15710947, 15897572, 15118125" +OncoKB,EGFR,Oncogenic,NA,GOF,NA,NA,NA,NA,17177598 +OncoKB,EGFR,Oncogenic,NA,GOF,NA,NA,NA,NA,"16166444, 24894453, 24743239" +OncoKB,EGFR,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,27478040 +OncoKB,EGFR,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"19536777, 17974985, 18676761" +OncoKB,EGFR,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,"23380224, 21172876, 19536777, 25057940, 18000506, 18355544" +OncoKB,EGFR,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,21531810 +OncoKB,EGFR,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,"17376509, 16204011, 15897572" +OncoKB,EGFR,Likely Oncogenic,NA,Likely SOF,NA,NA,NA,NA,22270724 +OncoKB,EGFR,Oncogenic,NA,GOF,NA,NA,NA,NA,"15329413, 18000506, 15118125, 19536777, 18458038, 15118073, 22019513, 23566546, 23559152, 24457318, 22760226, 23749122, 17192902" +OncoKB,EGFR,Oncogenic,NA,GOF,NA,NA,NA,NA,24747966 +OncoKB,EGFR,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"23139256, 18000506, 19238633, 25435280" +OncoKB,EGFR,Oncogenic,NA,GOF,NA,NA,NA,NA,"23371856, 19536777, 24353160, 21764376, 18676761, 15897572, 17686547" +OncoKB,EGFR,Oncogenic,NA,GOF,NA,NA,NA,NA,"24120142, 17177598, 22588883" +OncoKB,EGFR,Oncogenic,NA,GOF,NA,NA,NA,NA,"23371856, 19536777, 24353160, 21764376, 18676761, 15897572, 17686547" +OncoKB,EGFR,Oncogenic,NA,GOF,NA,NA,NA,NA,"18325048, 22190593" +OncoKB,EGFR,Oncogenic,NA,GOF,NA,NA,NA,NA,27102076 +OncoKB,EGFR,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,"21531810, 23605641, 19147750, 16152581" +OncoKB,EGFR,Oncogenic,NA,GOF,NA,NA,NA,NA,"23585556, 19147750, 21761100, 22722798, 16551849" +OncoKB,EGFR,Likely Neutral,NA,Likely LOF,NA,NA,NA,NA,24063894 +OncoKB,EGFR,Oncogenic,NA,GOF,NA,NA,NA,NA,26286086 +OncoKB,EGFR,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,19536777 +OncoKB,EGFR,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"21531810, 23749122" +OncoKB,EGFR,Likely Neutral,NA,LOF,NA,NA,NA,NA,24063894 +OncoKB,EGFR,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"17973572, 18309959, 18645621, 19632948, 18981003" +OncoKB,EGFR,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,19147750 +OncoKB,EGFR,Oncogenic,NA,GOF,NA,NA,NA,NA,"15118073, 15329413, 18261621, 15118125" +OncoKB,EGFR,Likely Neutral,NA,LOF,NA,NA,NA,NA,21081186 +OncoKB,EGFR,Likely Neutral,NA,LOF,NA,NA,NA,NA,19147750 +OncoKB,EGFR,Likely Neutral,NA,COF,NA,NA,NA,NA,"23897956, 22848293, 25176975, 23912954, 17877814" +OncoKB,EGFR,Oncogenic,NA,GOF,NA,NA,NA,NA,"15118073, 15329413, 25179728, 15118125" +OncoKB,EGFR,Oncogenic,NA,GOF,NA,NA,NA,NA,"23371856, 19536777, 24353160, 21764376, 18676761, 15897572, 17686547" +OncoKB,EGFR,Likely Oncogenic,NA,COF,NA,NA,NA,NA,25633215 +OncoKB,EGFR,Oncogenic,NA,GOF,NA,NA,NA,NA,"19147750, 15897572" +OncoKB,EGFR,Oncogenic,NA,GOF,NA,NA,NA,NA,"21531810, 26206867" +OncoKB,EGFR,Oncogenic,NA,GOF,NA,NA,NA,NA,"23371856, 19536777, 24353160, 21764376, 18676761, 15897572, 17686547" +OncoKB,EGFR,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,27102076 +OncoKB,EGFR,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,23912954 +OncoKB,EGFR,Oncogenic,NA,GOF,NA,NA,NA,NA,"15118073, 15329413, 15118125, 17192902" +OncoKB,EGFR,Oncogenic,NA,GOF,NA,NA,NA,NA,"21531810, 26206867" +OncoKB,EGFR,Oncogenic,NA,GOF,NA,NA,NA,NA,"16467085, 15118073, 15329413, 15118125" +OncoKB,EGFR,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,19147750 +OncoKB,EGFR,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,"21531810, 19671738, 23242437, 18261621, 23566546, 22483783, 23749122, 20479403, 15710947, 18372921, 21841502" +OncoKB,EGFR,Oncogenic,NA,GOF,NA,NA,NA,NA,"23371856, 19536777, 24353160, 21764376, 18676761, 15897572, 17686547" +OncoKB,EGFR,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,"20942962, 16870303" +OncoKB,EGFR,Oncogenic,NA,GOF,NA,NA,NA,NA,"18508816, 15118073, 15329413, 15897572, 15118125" +OncoKB,EGFR,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,18193092 +OncoKB,EGFR,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,19536777 +OncoKB,EGFR,Oncogenic,NA,GOF,NA,NA,NA,NA,24353160 +OncoKB,EGFR,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,"20942962, 17224267" +OncoKB,EGFR,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,23749122 +OncoKB,EGFR,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,"26571394, 27245685" +OncoKB,EGFR,Oncogenic,NA,GOF,NA,NA,NA,NA,"23371856, 19536777, 24353160, 21764376, 18676761, 23912954, 15897572, 17686547" +OncoKB,EGFR,Oncogenic,NA,GOF,NA,NA,NA,NA,"15118073, 15329413, 15710947, 15897572, 15118125" +OncoKB,EGFR,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,23912954 +OncoKB,EGFR,Oncogenic,NA,GOF,NA,NA,NA,NA,"24120142, 17177598, 22588883" +OncoKB,EGFR,Oncogenic,NA,GOF,NA,NA,NA,NA,24212795 +OncoKB,EGFR,Oncogenic,NA,GOF,NA,NA,NA,NA,"18325048, 15118073, 15329413, 15118125" +OncoKB,EGFR,Oncogenic,NA,GOF,NA,NA,NA,NA,"23371856, 19536777, 24353160, 21764376, 18676761, 15897572, 17686547" +OncoKB,EGFR,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"16533793, 26773740, 24385129, 23485129, 26096169, 22190593" +OncoKB,EGFR,Oncogenic,NA,GOF,NA,NA,NA,NA,"18508816, 15118073, 15329413, 19147750, 25179728, 15710947, 15897572, 15118125" +OncoKB,EGFR,Oncogenic,NA,GOF,NA,NA,NA,NA,"24120142, 10728703" +OncoKB,EGFR,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,18325048 +OncoKB,EGFR,Oncogenic,NA,GOF,NA,NA,NA,NA,"19625781, 25179728, 15737014, 16187797" +OncoKB,EGFR,Oncogenic,NA,GOF,NA,NA,NA,NA,"19726454, 23566546, 18000506, 25179728, 25130612, 23749122, 15710947, 26206867" +OncoKB,EGFR,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,20942962 +OncoKB,EGFR,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,15897572 +OncoKB,EGFR,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"17177598, 23243055" +OncoKB,EGFR,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"21531810, 18000506, 26206867" +OncoKB,EGFR,Oncogenic,NA,GOF,NA,NA,NA,NA,"15118073, 15329413, 15710947, 15118125" +OncoKB,EGFR,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"18676761, 15897572" +OncoKB,EGFR,Oncogenic,NA,GOF,NA,NA,NA,NA,"16205628, 21949883, 23912954, 25130612, 20808254, 21422421" +OncoKB,EGFR,Oncogenic,NA,GOF,NA,NA,NA,NA,"20676128, 23007009" +OncoKB,EGFR,Oncogenic,NA,GOF,NA,NA,NA,NA,"23371856, 19536777, 24353160, 21764376, 18676761, 23749122, 15897572, 17686547" +OncoKB,EGFR,Likely Neutral,NA,COF,NA,NA,NA,NA,24747966 +OncoKB,EGFR,Oncogenic,NA,GOF,NA,NA,NA,NA,"18508816, 15118073, 15329413, 15118125, 17192902" +OncoKB,EGFR,Likely Neutral,NA,LOF,NA,NA,NA,NA,19147750 +OncoKB,NKX2-1,Oncogenic,NA,GOF,NA,NA,NA,NA,"17925434, 18212743, 22439932" +OncoKB,NKX2-1,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,21481790 +OncoKB,NKX2-1,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,19176457 +OncoKB,NKX2-1,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,21481790 +OncoKB,NKX2-1,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,21481790 +OncoKB,NKX2-1,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,21481790 +OncoKB,EIF1AX,Oncogenic,NA,GOF,NA,NA,NA,NA,26878173 +OncoKB,ARID2,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"23047306, 21822264, 15985610, 16847454" +OncoKB,ARID2,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"23047306, 22095441, 15985610, 16847454" +OncoKB,BRD4,Oncogenic,NA,GOF,NA,NA,NA,NA,"23604113, 21447744, 25512383, 20676058, 17934517, 20871596" +OncoKB,BRD4,Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"12543779, 23128391, 25564152" +OncoKB,BRD4,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,"12192049, 19596781, 15456879" +OncoKB,HIST1H1C,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,24362818 +OncoKB,ERRFI1,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"16648858, 21113414" +OncoKB,ERRFI1,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA, +OncoKB,CHEK2,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,"16835864, 16982735" +OncoKB,CHEK2,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,"16816021, 11571648, 15239132, 11053450, 14612911, 15492928, 11298456, 12049740" +OncoKB,CHEK2,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,"21618645, 25884806" +OncoKB,CHEK2,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,16835864 +OncoKB,CHEK2,Oncogenic,NA,LOF,NA,NA,NA,NA,27716909 +OncoKB,CHEK2,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"16998506, 15649950" +OncoKB,CHEK2,Likely Neutral,NA,COF,NA,NA,NA,NA,"16998506, 15649950" +OncoKB,CHEK2,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,16982735 +OncoKB,PAK1,Oncogenic,NA,GOF,NA,NA,NA,NA,"21482786, 22105362" +OncoKB,TMPRSS2,Oncogenic,NA,GOF,NA,NA,NA,NA,"7731694, 16213704, 17043636" +OncoKB,TMPRSS2,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"16254181, 18283340" +OncoKB,TMPRSS2,Likely Neutral,NA,COF,NA,NA,NA,NA,"11745466, 25040002" +OncoKB,TMPRSS2,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,18172298 +OncoKB,TMPRSS2,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,16585160 +OncoKB,TMPRSS2,Likely Neutral,NA,COF,NA,NA,NA,NA,"11745466, 25040002" +OncoKB,TMPRSS2,Oncogenic,NA,GOF,NA,NA,NA,NA,"18563191, 23512661" +OncoKB,H3F3A,Likely Oncogenic,NA,Likely SOF,NA,NA,NA,NA,"21685365, 22286061" +OncoKB,H3F3A,Likely Oncogenic,NA,Likely SOF,NA,NA,NA,NA,"21685365, 23079654, 22286061" +OncoKB,H3F3A,Likely Oncogenic,NA,Likely SOF,NA,NA,NA,NA,"21685365, 23079654, 22286061" +OncoKB,ELF3,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,17148437 +OncoKB,ELF3,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"14976186, 17148437" +OncoKB,ELF3,Likely Neutral,NA,COF,NA,NA,NA,NA,17148437 +OncoKB,ELF3,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,17148437 +OncoKB,ELF3,Likely Neutral,NA,COF,NA,NA,NA,NA,17148437 +OncoKB,ELF3,Likely Neutral,NA,COF,NA,NA,NA,NA,17148437 +OncoKB,ELF3,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,17148437 +OncoKB,ROS1,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,27401242 +OncoKB,ROS1,Oncogenic,NA,GOF,NA,NA,NA,NA,"22919003, 22215748, 18083107, 22327623" +OncoKB,ROS1,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"25204415, 23637631" +OncoKB,ROS1,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,24218589 +OncoKB,ROS1,Oncogenic,NA,GOF,NA,NA,NA,NA,"12661006, 2827175" +OncoKB,ROS1,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"22235099, 25688157, 24675041" +OncoKB,ROS1,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,22980976 +OncoKB,ROS1,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,24218589 +OncoKB,ROS1,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,26673800 +OncoKB,ROS1,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,25351743 +OncoKB,ROS1,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,24218589 +OncoKB,ROS1,Oncogenic,NA,GOF,NA,NA,NA,NA,"22919003, 22215748, 22327623" +OncoKB,ROS1,Oncogenic,NA,GOF,NA,NA,NA,NA,22327623 +OncoKB,ROS1,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,24875859 +OncoKB,ROS1,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,27401242 +OncoKB,ROS1,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"25351743, 24047073, 24047072, 23724914, 27401242, 25688157" +OncoKB,ROS1,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"22919003, 23719267, 22215748" +OncoKB,ROS1,Oncogenic,NA,GOF,NA,NA,NA,NA,"22919003, 22215748, 18083107, 22327623" +OncoKB,ROS1,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,24875859 +OncoKB,ROS1,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,25264305 +OncoKB,ROS1,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,25264305 +OncoKB,ROS1,Oncogenic,NA,GOF,NA,NA,NA,NA,22327623 +OncoKB,ROS1,Oncogenic,NA,GOF,NA,NA,NA,NA,22327623 +OncoKB,ROS1,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,25978031 +OncoKB,ROS1,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,24218589 +OncoKB,ROS1,Oncogenic,NA,GOF,NA,NA,NA,NA,22327623 +OncoKB,ROS1,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,24218589 +OncoKB,ROS1,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"22975805, 25870798" +OncoKB,ASXL2,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,24973361 +OncoKB,ASXL2,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,24973361 +OncoKB,CDH1,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,24690483 +OncoKB,CDH1,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"15235021, 17545690" +OncoKB,CDH1,Oncogenic,NA,LOF,NA,NA,NA,NA,12588804 +OncoKB,CDH1,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"23812922, 2070412, 23341533, 19168852, 9515965, 24037103" +OncoKB,CDH1,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"11313896, 7543680" +OncoKB,CDH1,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,12588804 +OncoKB,CDH1,Oncogenic,NA,LOF,NA,NA,NA,NA,12588804 +OncoKB,CDH1,Oncogenic,NA,LOF,NA,NA,NA,NA,26123647 +OncoKB,CDH1,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"8934538, 2070412, 9515965, 17522512" +OncoKB,CDH1,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,24204729 +OncoKB,EPCAM,Oncogenic,NA,LOF,NA,NA,NA,NA,21145788 +OncoKB,TOP1,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA, +OncoKB,EP300,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,"18778367, 23307074, 9389684, 20980053" +OncoKB,EP300,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"10700188, 12402157, 12237408" +OncoKB,EP300,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"25943178, 26293203, 23307074" +OncoKB,EP300,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"10700188, 15156177, 12402157, 12237408" +OncoKB,EP300,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,"12586840, 25151357" +OncoKB,EP300,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,25151357 +OncoKB,EP300,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,18273021 +OncoKB,EP300,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,"10824998, 23307074, 11243405" +OncoKB,EP300,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,25151357 +OncoKB,EP300,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,18273021 +OncoKB,EPAS1,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"23054256, 14691554, 12086860" +OncoKB,EPAS1,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"22931260, 23418310" +OncoKB,EPAS1,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"23361906, 23653463" +OncoKB,EPAS1,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"22931260, 23418310" +OncoKB,EPAS1,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"22931260, 23418310" +OncoKB,EPAS1,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"22931260, 23418310" +OncoKB,EPAS1,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"22931260, 23418310" +OncoKB,EPAS1,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"22931260, 23418310" +OncoKB,TP53,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,22540896 +OncoKB,TP53,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,25408419 +OncoKB,TP53,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,17947339 +OncoKB,TP53,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,"17361096, 22427690" +OncoKB,TP53,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,20407015 +OncoKB,TP53,Likely Neutral,NA,COF,NA,NA,NA,NA,25584008 +OncoKB,TP53,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,21445056 +OncoKB,TP53,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,19462533 +OncoKB,TP53,Oncogenic,NA,LOF,NA,NA,NA,NA,"17724467, 8023157, 26619011, 22862161, 11900253" +OncoKB,TP53,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,16827139 +OncoKB,TP53,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,"10229196, 25584008" +OncoKB,TP53,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"19454241, 20978130" +OncoKB,TP53,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"21445056, 16778209" +OncoKB,TP53,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"19336573, 27759562, 16007150, 11753428, 11900253, 21467160" +OncoKB,TP53,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"15781620, 8023157, 11900253" +OncoKB,TP53,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,16827139 +OncoKB,TP53,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"26619011, 20978130" +OncoKB,TP53,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"19454241, 20978130" +OncoKB,TP53,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,19454241 +OncoKB,TP53,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,25408419 +OncoKB,TP53,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"26748848, 25584008" +OncoKB,TP53,Oncogenic,NA,LOF,NA,NA,NA,NA,26818906 +OncoKB,TP53,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,15781620 +OncoKB,TP53,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,7651437 +OncoKB,TP53,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"17914575, 8023157, 11900253" +OncoKB,TP53,Oncogenic,NA,LOF,NA,NA,NA,NA,"18524770, 24814347, 17189187" +OncoKB,TP53,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"24677579, 26619011" +OncoKB,TP53,Oncogenic,NA,LOF,NA,NA,NA,NA,17189187 +OncoKB,TP53,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,"18762571, 10229196, 25584008" +OncoKB,TP53,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"19462533, 26619011" +OncoKB,TP53,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,26748848 +OncoKB,TP53,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"15781620, 8023157, 26619011, 11900253" +OncoKB,TP53,Oncogenic,NA,LOF,NA,NA,NA,NA,24714748 +OncoKB,TP53,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,20471942 +OncoKB,TP53,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,7651437 +OncoKB,TP53,Oncogenic,NA,LOF,NA,NA,NA,NA,23150443 +OncoKB,TP53,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,17724467 +OncoKB,TP53,Oncogenic,NA,LOF,NA,NA,NA,NA,11160722 +OncoKB,TP53,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,"10229196, 26748848, 16861262" +OncoKB,TP53,Likely Neutral,NA,COF,NA,NA,NA,NA,"16687402, 18996393" +OncoKB,TP53,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"15781620, 8023157, 26619011, 11900253" +OncoKB,TP53,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,8633021 +OncoKB,TP53,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,21383700 +OncoKB,TP53,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"19454241, 20978130" +OncoKB,TP53,Oncogenic,NA,LOF,NA,NA,NA,NA,"8023157, 11900253" +OncoKB,TP53,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"19454241, 20978130, 11481490" +OncoKB,TP53,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"9632751, 26619011, 22955915" +OncoKB,TP53,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,17914575 +OncoKB,TP53,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,"7651437, 17189187" +OncoKB,TP53,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,19681600 +OncoKB,TP53,Oncogenic,NA,LOF,NA,NA,NA,NA,25584008 +OncoKB,TP53,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,11896595 +OncoKB,TP53,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,15781620 +OncoKB,TP53,Oncogenic,NA,LOF,NA,NA,NA,NA,"15781620, 10713666, 21445056, 25584008, 22114072" +OncoKB,TP53,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,17530187 +OncoKB,TP53,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"24814347, 21445056, 16778209" +OncoKB,TP53,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,20471942 +OncoKB,TP53,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,19462533 +OncoKB,TP53,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,10871862 +OncoKB,TP53,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"19454241, 20978130" +OncoKB,TP53,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"15781620, 8023157, 11900253" +OncoKB,TP53,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,24076587 +OncoKB,TP53,Oncogenic,NA,LOF,NA,NA,NA,NA,22553460 +OncoKB,TP53,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"15037740, 11870884" +OncoKB,TP53,Likely Neutral,NA,Likely GOF,NA,NA,NA,NA,15781620 +OncoKB,TP53,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,20978130 +OncoKB,TP53,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,19462533 +OncoKB,TP53,Likely Neutral,NA,COF,NA,NA,NA,NA,25584008 +OncoKB,TP53,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,18453682 +OncoKB,TP53,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,"8023157, 23246812, 15037740, 25584008, 11900253, 15077194" +OncoKB,TP53,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,15781620 +OncoKB,TP53,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"15781620, 26619011" +OncoKB,TP53,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,10229196 +OncoKB,TP53,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,22710932 +OncoKB,TP53,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,11429705 +OncoKB,TP53,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"19454241, 25584008, 11481490" +OncoKB,TP53,Oncogenic,NA,LOF,NA,NA,NA,NA,"2358418, 15037740" +OncoKB,TP53,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"8023157, 22908277, 11900253" +OncoKB,TP53,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,7651437 +OncoKB,TP53,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"15781620, 8023157, 26619011, 11900253" +OncoKB,TP53,Oncogenic,NA,LOF,NA,NA,NA,NA,"26181206, 15037740, 25584008" +OncoKB,TP53,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"20407015, 26619011" +OncoKB,TP53,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,8633021 +OncoKB,TP53,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"26982726, 27759562, 19477430, 11900253, 12584563" +OncoKB,TP53,Oncogenic,NA,LOF,NA,NA,NA,NA,"8023157, 11900253" +OncoKB,TP53,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"21232794, 16827139" +OncoKB,TP53,Oncogenic,NA,LOF,NA,NA,NA,NA,2857548 +OncoKB,TP53,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"15781620, 26619011, 12917626" +OncoKB,TP53,Likely Neutral,NA,COF,NA,NA,NA,NA,19462533 +OncoKB,TP53,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,"19454241, 20978130, 19106109" +OncoKB,TP53,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,20978130 +OncoKB,TP53,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"19454241, 20978130" +OncoKB,TP53,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"21445056, 18996393, 14741214" +OncoKB,TP53,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"24814347, 16687402" +OncoKB,TP53,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"10618702, 2553699, 20010306" +OncoKB,TP53,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,15781620 +OncoKB,TP53,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,10229196 +OncoKB,TP53,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,21445056 +OncoKB,TP53,Oncogenic,NA,LOF,NA,NA,NA,NA,"23315175, 15037740, 23630318" +OncoKB,TP53,Oncogenic,NA,LOF,NA,NA,NA,NA,"8023157, 11900253" +OncoKB,TP53,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,12901798 +OncoKB,TP53,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,25584008 +OncoKB,TP53,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,20407015 +OncoKB,TP53,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,11668476 +OncoKB,TP53,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,"10229196, 20471942" +OncoKB,TP53,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"25119136, 22803791, 22214764" +OncoKB,TP53,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,"19454241, 17311302, 16007150, 19106109, 11753428" +OncoKB,TP53,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,20407015 +OncoKB,TP53,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,15037740 +OncoKB,TP53,Oncogenic,NA,LOF,NA,NA,NA,NA,"8023157, 11900253" +OncoKB,TP53,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"15781620, 8023157, 11900253" +OncoKB,TP53,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,15037740 +OncoKB,TP53,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,15977174 +OncoKB,TP53,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,9627118 +OncoKB,TP53,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,"19454241, 20978130" +OncoKB,TP53,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,24814347 +OncoKB,TP53,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,19454241 +OncoKB,TP53,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,9472631 +OncoKB,TP53,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,10435620 +OncoKB,TP53,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,"10229196, 25584008" +OncoKB,TP53,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,"8023157, 15037740, 11900253" +OncoKB,TP53,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,12782597 +OncoKB,TP53,Oncogenic,NA,LOF,NA,NA,NA,NA,23981578 +OncoKB,TP53,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"15781620, 8023157, 11900253" +OncoKB,TP53,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,25584008 +OncoKB,TP53,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,20407015 +OncoKB,TP53,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,20407015 +OncoKB,TP53,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,22999923 +OncoKB,TP53,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,16861262 +OncoKB,TP53,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,21445056 +OncoKB,TP53,Oncogenic,NA,LOF,NA,NA,NA,NA,"18762572, 25584008" +OncoKB,TP53,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,20978130 +OncoKB,TP53,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,20978130 +OncoKB,TP53,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,20505364 +OncoKB,TP53,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,"15037740, 25584008, 16861262" +OncoKB,TP53,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,10435620 +OncoKB,TP53,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"15037740, 23863845, 11900253, 23612969" +OncoKB,TP53,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,15781620 +OncoKB,TP53,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,19462533 +OncoKB,TP53,Oncogenic,NA,LOF,NA,NA,NA,NA,23612969 +OncoKB,TP53,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"15781620, 8023157, 11900253" +OncoKB,TP53,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,7651437 +OncoKB,TP53,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"21561095, 15037740, 16778209" +OncoKB,TP53,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"19454241, 20978130, 11481490" +OncoKB,TP53,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"15781620, 8023157, 26619011, 11900253" +OncoKB,TP53,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,18996393 +OncoKB,TP53,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"8023157, 11900253, 12700230" +OncoKB,TP53,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,10435620 +OncoKB,TP53,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,21760996 +OncoKB,TP53,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,7651437 +OncoKB,TP53,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,21445056 +OncoKB,TP53,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,22989750 +OncoKB,TP53,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,10229196 +OncoKB,TP53,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,15037740 +OncoKB,TP53,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,20589832 +OncoKB,TP53,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,"17999388, 15037740" +OncoKB,TP53,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,25584008 +OncoKB,TP53,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,21311097 +OncoKB,TP53,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,"15781620, 18762572, 25584008" +OncoKB,TP53,Oncogenic,NA,LOF,NA,NA,NA,NA,25584008 +OncoKB,TP53,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"20407015, 26619011" +OncoKB,TP53,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,10229196 +OncoKB,TP53,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,10229196 +OncoKB,TP53,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"18524770, 24814347, 17189187" +OncoKB,TP53,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,25119136 +OncoKB,TP53,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"19454241, 20978130" +OncoKB,TP53,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,24814347 +OncoKB,TP53,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,26748848 +OncoKB,TP53,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"10435620, 25584008" +OncoKB,TP53,Oncogenic,NA,LOF,NA,NA,NA,NA,"8023157, 11900253" +OncoKB,TP53,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,25584637 +OncoKB,TP53,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,20978130 +OncoKB,TP53,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,17401432 +OncoKB,TP53,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,22090360 +OncoKB,TP53,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,19462533 +OncoKB,TP53,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"23264849, 22989750" +OncoKB,TP53,Likely Oncogenic,NA,SOF,NA,NA,NA,NA,22847613 +OncoKB,TP53,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"15037740, 22803791" +OncoKB,TP53,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,"24814347, 20471942" +OncoKB,TP53,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,7651437 +OncoKB,TP53,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"26619011, 25584008" +OncoKB,TP53,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,25584008 +OncoKB,TP53BP1,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,23103855 +OncoKB,TP53BP1,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"16260621, 22915756" +OncoKB,SMAD2,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,"15133179, 20010874, 16382155, 18618014, 12384562, 22204491, 19276350, 20852387" +OncoKB,SMAD2,Likely Neutral,NA,COF,NA,NA,NA,NA,11274206 +OncoKB,SMAD2,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,23139211 +OncoKB,SMAD2,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,11274206 +OncoKB,SMAD2,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,23139211 +OncoKB,SMAD2,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,11779503 +OncoKB,SMAD2,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,11779503 +OncoKB,SMAD2,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,11274206 +OncoKB,SMAD2,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"11779503, 9463378" +OncoKB,SMAD2,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,11779503 +OncoKB,SMAD2,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,23139211 +OncoKB,SMAD2,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,23139211 +OncoKB,SMAD2,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"14729957, 11779503" +OncoKB,SMAD2,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,11779503 +OncoKB,SMAD2,Likely Neutral,NA,COF,NA,NA,NA,NA,"11274206, 11779503" +OncoKB,SMAD2,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"11274206, 11779503" +OncoKB,SMAD2,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,11779503 +OncoKB,SMAD2,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,"16828225, 20937913" +OncoKB,SMAD2,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,23139211 +OncoKB,SMAD2,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"12894231, 23139211, 15711891, 11779503" +OncoKB,SMAD2,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,23139211 +OncoKB,SMAD3,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,11691834 +OncoKB,SMAD3,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,21949838 +OncoKB,SMAD3,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,21949838 +OncoKB,SMAD3,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,21949838 +OncoKB,SMAD3,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,21949838 +OncoKB,SMAD3,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,23139211 +OncoKB,SMAD3,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,21949838 +OncoKB,SMAD3,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,21949838 +OncoKB,SMAD3,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,21949838 +OncoKB,SMAD3,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,21949838 +OncoKB,SMAD3,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,23139211 +OncoKB,SMAD3,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,23139211 +OncoKB,SMAD3,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"14647420, 18852474, 9753318, 16951153" +OncoKB,SMAD3,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,16828225 +OncoKB,SMAD3,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,21949838 +OncoKB,SMAD3,Likely Neutral,NA,COF,NA,NA,NA,NA,17994767 +OncoKB,SMAD3,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,23139211 +OncoKB,SMAD3,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,17994767 +OncoKB,SMAD3,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,10092624 +OncoKB,SMAD3,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,21949838 +OncoKB,SMAD3,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,23139211 +OncoKB,SMAD3,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,21949838 +OncoKB,SMAD3,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,17994767 +OncoKB,SMAD3,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,10092624 +OncoKB,SMAD3,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,21949838 +OncoKB,SMAD4,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,14647410 +OncoKB,SMAD4,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,17994767 +OncoKB,SMAD4,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,11274206 +OncoKB,SMAD4,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,14647410 +OncoKB,SMAD4,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,22109972 +OncoKB,SMAD4,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,14647410 +OncoKB,SMAD4,Likely Neutral,NA,COF,NA,NA,NA,NA,"11274206, 11779503, 10822381" +OncoKB,SMAD4,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,"22321641, 25893305, 9482899, 10626800, 9506519, 17114584, 19841536, 10773876" +OncoKB,SMAD4,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,"11274206, 19139564" +OncoKB,SMAD4,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,15350224 +OncoKB,SMAD4,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,14647410 +OncoKB,SMAD4,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"23139211, 10340381, 15711891, 9094310, 11553622" +OncoKB,SMAD4,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,26488212 +OncoKB,SMAD4,Likely Oncogenic,NA,COF,NA,NA,NA,NA,"11274206, 11779503" +OncoKB,SMAD4,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,"14647410, 10092624" +OncoKB,SMAD4,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,11779503 +OncoKB,SMAD4,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,14715079 +OncoKB,SMAD4,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,22316667 +OncoKB,SMAD4,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,11779503 +OncoKB,SMAD4,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,14647410 +OncoKB,SMAD4,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,26488212 +OncoKB,SMAD4,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,"9214508, 23139211, 14715079" +OncoKB,SMAD4,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,11779503 +OncoKB,SMAD4,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,25275298 +OncoKB,SMAD4,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,22316667 +OncoKB,SMAD4,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,"9214508, 14647410, 26488212, 10092624" +OncoKB,SMAD4,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,11779503 +OncoKB,SMAD4,Oncogenic,NA,LOF,NA,NA,NA,NA,"23139211, 14715079" +OncoKB,SMAD4,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"9214508, 11274206, 10092624, 19139564, 11779503" +OncoKB,SMAD4,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,14647410 +OncoKB,SMAD4,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,26619011 +OncoKB,SMAD4,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,"9214508, 14647410, 11274206, 11779503, 14715079" +OncoKB,SMAD4,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"9214508, 9153220" +OncoKB,SMAD4,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,15350224 +OncoKB,SMAD4,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,26488212 +OncoKB,SMAD4,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,11274206 +OncoKB,SMAD4,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,22316667 +OncoKB,CDK4,Oncogenic,NA,GOF,NA,NA,NA,NA,"11606789, 11756559" +OncoKB,CDK4,Oncogenic,NA,GOF,NA,NA,NA,NA,"20534551, 8101826, 10970848" +OncoKB,CDK4,Oncogenic,NA,GOF,NA,NA,NA,NA,"9426066, 9712735, 9228064" +OncoKB,AURKB,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"17344846, 26240282, 18347165, 16222316" +OncoKB,AURKB,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,26240282 +OncoKB,CDK6,Oncogenic,NA,GOF,NA,NA,NA,NA,"17989712, 23127611, 11940479, 20534551, 24736461, 22476749, 12900351, 19145199, 24764564" +OncoKB,CDK6,Likely Neutral,NA,LOF,NA,NA,NA,NA,23918663 +OncoKB,FBXW7,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"24838835, 26619011" +OncoKB,FBXW7,Oncogenic,NA,LOF,NA,NA,NA,NA,17646409 +OncoKB,FBXW7,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,20815813 +OncoKB,FBXW7,Likely Neutral,NA,COF,NA,NA,NA,NA,27147599 +OncoKB,FBXW7,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,"27147599, 24912918, 23228967, 17575125, 22608923" +OncoKB,FBXW7,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"11565034, 19420964" +OncoKB,FBXW7,Likely Neutral,NA,COF,NA,NA,NA,NA,24838835 +OncoKB,FBXW7,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"17646409, 15103331, 18094723" +OncoKB,FBXW7,Oncogenic,NA,LOF,NA,NA,NA,NA,"27147599, 17646408, 17575125, 23228967, 24838835, 22608923, 23095493" +OncoKB,FBXW7,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,21620836 +OncoKB,FBXW7,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"25314076, 27764699, 18367647, 15103331" +OncoKB,FBXW7,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,17575125 +OncoKB,FBXW7,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"27147599, 26619011" +OncoKB,FBXW7,Likely Neutral,NA,COF,NA,NA,NA,NA,27147599 +OncoKB,FBXW7,Likely Neutral,NA,Likely GOF,NA,NA,NA,NA,22608923 +OncoKB,FBXW7,Oncogenic,NA,LOF,NA,NA,NA,NA,"17646408, 17909001, 17646409, 23095493" +OncoKB,FBXW7,Oncogenic,NA,LOF,NA,NA,NA,NA,"17646408, 17909001, 23228967, 17646409" +OncoKB,FBXW7,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"27147599, 26619011" +OncoKB,FBXW7,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,"24912918, 22608923" +OncoKB,FBXW7,Oncogenic,NA,LOF,NA,NA,NA,NA,23676439 +OncoKB,FBXW7,Oncogenic,NA,LOF,NA,NA,NA,NA,"19739118, 24884509, 18367647, 18094723, 25555218, 22673505" +OncoKB,CDK8,Oncogenic,NA,GOF,NA,NA,NA,NA,18794900 +OncoKB,CDKN1A,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,"7655464, 20127253, 18046503, 17293864" +OncoKB,CDKN1A,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"23159848, 24317508" +OncoKB,CDKN1A,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"19106607, 25483104, 23624841, 15960923" +OncoKB,CDKN1B,Oncogenic,NA,LOF,NA,NA,NA,NA,"8646779, 23460367, 18073348, 21422114" +OncoKB,CDKN1B,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,21289244 +OncoKB,CDKN1B,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"23555276, 8646779, 22129891, 21423803, 20492666, 25416039" +OncoKB,CDKN1B,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,21289244 +OncoKB,CDKN1B,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,"22823061, 23652671" +OncoKB,CDKN2A,Oncogenic,NA,LOF,NA,NA,NA,NA,"10491434, 19260062" +OncoKB,CDKN2A,Oncogenic,NA,LOF,NA,NA,NA,NA,"20340136, 19260062, 10389768" +OncoKB,CDKN2A,Oncogenic,NA,LOF,NA,NA,NA,NA,"20340136, 19260062" +OncoKB,CDKN2A,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,12606942 +OncoKB,CDKN2A,Oncogenic,NA,LOF,NA,NA,NA,NA,10491434 +OncoKB,CDKN2A,Oncogenic,NA,LOF,NA,NA,NA,NA,7647780 +OncoKB,CDKN2A,Oncogenic,NA,LOF,NA,NA,NA,NA,"10491434, 19260062" +OncoKB,CDKN2A,Oncogenic,NA,LOF,NA,NA,NA,NA,20340136 +OncoKB,CDKN2A,Oncogenic,NA,LOF,NA,NA,NA,NA,20340136 +OncoKB,CDKN2A,Oncogenic,NA,LOF,NA,NA,NA,NA,"24071852, 9516223" +OncoKB,CDKN2A,Oncogenic,NA,LOF,NA,NA,NA,NA,"20340136, 19260062, 10389768" +OncoKB,CDKN2A,Oncogenic,NA,LOF,NA,NA,NA,NA,20340136 +OncoKB,CDKN2A,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,9660926 +OncoKB,CDKN2A,Oncogenic,NA,LOF,NA,NA,NA,NA,10491434 +OncoKB,CDKN2A,Oncogenic,NA,LOF,NA,NA,NA,NA,"20340136, 19260062" +OncoKB,CDKN2A,Oncogenic,NA,LOF,NA,NA,NA,NA,20340136 +OncoKB,CDKN2A,Oncogenic,NA,LOF,NA,NA,NA,NA,"19260062, 8755727" +OncoKB,CDKN2A,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,"20340136, 19260062" +OncoKB,CDKN2A,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,"8755727, 10498896" +OncoKB,CDKN2A,Oncogenic,NA,LOF,NA,NA,NA,NA,"20340136, 19260062" +OncoKB,CDKN2A,Oncogenic,NA,LOF,NA,NA,NA,NA,19260062 +OncoKB,CDKN2A,Oncogenic,NA,LOF,NA,NA,NA,NA,20340136 +OncoKB,CDKN2A,Oncogenic,NA,LOF,NA,NA,NA,NA,7647780 +OncoKB,CDKN2A,Oncogenic,NA,LOF,NA,NA,NA,NA,"20340136, 19260062" +OncoKB,CDKN2A,Oncogenic,NA,LOF,NA,NA,NA,NA,"10491434, 20340136, 19260062, 8755727" +OncoKB,CDKN2A,Oncogenic,NA,LOF,NA,NA,NA,NA,14508519 +OncoKB,CDKN2A,Oncogenic,NA,LOF,NA,NA,NA,NA,"20340136, 19260062" +OncoKB,CDKN2A,Oncogenic,NA,LOF,NA,NA,NA,NA,10491434 +OncoKB,CDKN2A,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,10491434 +OncoKB,CDKN2A,Oncogenic,NA,LOF,NA,NA,NA,NA,7987387 +OncoKB,CDKN2A,Oncogenic,NA,LOF,NA,NA,NA,NA,"10491434, 19260062, 9607312" +OncoKB,CDKN2A,Oncogenic,NA,LOF,NA,NA,NA,NA,10498896 +OncoKB,CDKN2A,Oncogenic,NA,LOF,NA,NA,NA,NA,"10491434, 9324288" +OncoKB,CDKN2A,Oncogenic,NA,LOF,NA,NA,NA,NA,20340136 +OncoKB,CDKN2A,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"20340136, 9324288, 8603820" +OncoKB,CDKN2A,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,"20340136, 19260062" +OncoKB,CDKN2A,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,"8755727, 7777061, 10498896" +OncoKB,CDKN2A,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,"20340136, 19260062" +OncoKB,CDKN2A,Oncogenic,NA,LOF,NA,NA,NA,NA,"20340136, 19260062" +OncoKB,CDKN2A,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,"15879498, 8603820, 7647780" +OncoKB,CDKN2A,Oncogenic,NA,LOF,NA,NA,NA,NA,"10491434, 9607312" +OncoKB,CDKN2A,Oncogenic,NA,LOF,NA,NA,NA,NA,19260062 +OncoKB,CDKN2A,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,"10491434, 19260062" +OncoKB,CDKN2A,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,12417717 +OncoKB,CDKN2A,Oncogenic,NA,LOF,NA,NA,NA,NA,20340136 +OncoKB,CDKN2A,Oncogenic,NA,LOF,NA,NA,NA,NA,7647780 +OncoKB,CDKN2A,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,7647780 +OncoKB,CDKN2A,Oncogenic,NA,LOF,NA,NA,NA,NA,20340136 +OncoKB,CDKN2A,Oncogenic,NA,LOF,NA,NA,NA,NA,10491434 +OncoKB,CDKN2A,Oncogenic,NA,LOF,NA,NA,NA,NA,10498896 +OncoKB,CDKN2A,Oncogenic,NA,LOF,NA,NA,NA,NA,20340136 +OncoKB,CDKN2A,Oncogenic,NA,LOF,NA,NA,NA,NA,20340136 +OncoKB,CDKN2A,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,"20340136, 19260062" +OncoKB,CDKN2A,Oncogenic,NA,LOF,NA,NA,NA,NA,"20340136, 19260062" +OncoKB,CDKN2A,Oncogenic,NA,LOF,NA,NA,NA,NA,"20340136, 19260062" +OncoKB,CDKN2A,Oncogenic,NA,LOF,NA,NA,NA,NA,"19260062, 8755727" +OncoKB,CDKN2A,Oncogenic,NA,LOF,NA,NA,NA,NA,10491434 +OncoKB,CDKN2A,Oncogenic,NA,LOF,NA,NA,NA,NA,20340136 +OncoKB,CDKN2B,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"12032783, 9479825, 11485924" +OncoKB,CDKN2B,Oncogenic,NA,LOF,NA,NA,NA,NA,25873077 +OncoKB,CDKN2B,Oncogenic,NA,LOF,NA,NA,NA,NA,"23715670, 25873077" +OncoKB,CDKN2B,Oncogenic,NA,LOF,NA,NA,NA,NA,"19064397, 17489980" +OncoKB,CDKN2B,Oncogenic,NA,LOF,NA,NA,NA,NA,25873077 +OncoKB,CDKN2B,Oncogenic,NA,LOF,NA,NA,NA,NA,25873077 +OncoKB,CDKN2B,Oncogenic,NA,LOF,NA,NA,NA,NA,"12032783, 8078588, 9479825" +OncoKB,CDKN2C,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"18829482, 21994415" +OncoKB,CDKN2C,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA, +OncoKB,ASXL1,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"24255920, 22897849, 24218140" +OncoKB,ASXL1,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"19388938, 24216483, 22897849, 21455215, 26095772" +OncoKB,ERBB2,Oncogenic,NA,GOF,NA,NA,NA,NA,"23220880, 22908275" +OncoKB,ERBB2,Likely Neutral,NA,LOF,NA,NA,NA,NA,1671296 +OncoKB,ERBB2,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,25435280 +OncoKB,ERBB2,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,18413839 +OncoKB,ERBB2,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,18039657 +OncoKB,ERBB2,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,24997986 +OncoKB,ERBB2,Oncogenic,NA,GOF,NA,NA,NA,NA,"23220880, 16843263, 22908275" +OncoKB,ERBB2,Likely Neutral,NA,LOF,NA,NA,NA,NA,23843458 +OncoKB,ERBB2,Likely Neutral,NA,COF,NA,NA,NA,NA,"22908275, 18772396, 18772890" +OncoKB,ERBB2,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,"24317180, 26545934" +OncoKB,ERBB2,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,22046346 +OncoKB,ERBB2,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,22046346 +OncoKB,ERBB2,Oncogenic,NA,GOF,NA,NA,NA,NA,23220880 +OncoKB,ERBB2,Oncogenic,NA,GOF,NA,NA,NA,NA,"23204226, 12124352, 2885917, 24656976, 10716706, 11571643" +OncoKB,ERBB2,Oncogenic,NA,GOF,NA,NA,NA,NA,"22908275, 18772890" +OncoKB,ERBB2,Oncogenic,NA,GOF,NA,NA,NA,NA,23220880 +OncoKB,ERBB2,Likely Neutral,NA,COF,NA,NA,NA,NA,24971884 +OncoKB,ERBB2,Likely Neutral,NA,COF,NA,NA,NA,NA,"22908275, 18772396, 18772890, 23389443" +OncoKB,ERBB2,Oncogenic,NA,GOF,NA,NA,NA,NA,"22908275, 18772890" +OncoKB,ERBB2,Oncogenic,NA,GOF,NA,NA,NA,NA,"24516025, 24997986, 22908275, 26358791" +OncoKB,ERBB2,Oncogenic,NA,GOF,NA,NA,NA,NA,17311002 +OncoKB,ERBB2,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,17638894 +OncoKB,ERBB2,Oncogenic,NA,GOF,NA,NA,NA,NA,"16775247, 23220880, 16843263, 23610105, 21353324, 22649146, 22325357, 25899785" +OncoKB,ERBB2,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,18413839 +OncoKB,ERBB2,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,18413839 +OncoKB,ERBB2,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"18413839, 25435280" +OncoKB,ERBB2,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"21531810, 26305917, 16397024" +OncoKB,ERBB2,Oncogenic,NA,GOF,NA,NA,NA,NA,"22046346, 18413839, 23220880" +OncoKB,ERBB2,Oncogenic,NA,GOF,NA,NA,NA,NA,"24997986, 23220880" +OncoKB,ERBB2,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,24997986 +OncoKB,ERBB2,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,18413839 +OncoKB,ERBB2,Oncogenic,NA,GOF,NA,NA,NA,NA,24971884 +OncoKB,ERBB2,Oncogenic,NA,GOF,NA,NA,NA,NA,"23220880, 23843458" +OncoKB,ERBB2,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"22046346, 26619011, 16299242" +OncoKB,ERBB2,Oncogenic,NA,GOF,NA,NA,NA,NA,23220880 +OncoKB,ERBB2,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,18413839 +OncoKB,ERBB2,Oncogenic,NA,GOF,NA,NA,NA,NA,22908275 +OncoKB,ERBB2,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,25435280 +OncoKB,ERBB2,Likely Neutral,NA,COF,NA,NA,NA,NA,23220880 +OncoKB,ERBB2,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,18413839 +OncoKB,ERBB2,Oncogenic,NA,GOF,NA,NA,NA,NA,"23220880, 15118073, 15329413, 15118125" +OncoKB,ERBB2,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,18413839 +OncoKB,ERBB2,Oncogenic,NA,GOF,NA,NA,NA,NA,26545934 +OncoKB,ERBB2,Oncogenic,NA,GOF,NA,NA,NA,NA,"22908275, 18772890" +OncoKB,ERBB2,Oncogenic,NA,GOF,NA,NA,NA,NA,"16775247, 23220880, 16843263, 23610105, 21353324, 22649146, 22325357, 25899785" +OncoKB,ERBB2,Likely Neutral,NA,LOF,NA,NA,NA,NA,"22393464, 23680147" +OncoKB,ERBB2,Likely Neutral,NA,COF,NA,NA,NA,NA,"22908275, 18772396, 18772890, 23389443" +OncoKB,ERBB2,Likely Neutral,NA,COF,NA,NA,NA,NA,"22908275, 18772396, 18772890, 23389443" +OncoKB,ERBB2,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,18413839 +OncoKB,ERBB2,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,"22046346, 25853726" +OncoKB,ERBB2,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,24971884 +OncoKB,ERBB2,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,27697991 +OncoKB,ERBB2,Oncogenic,NA,GOF,NA,NA,NA,NA,"24516025, 24997986, 22908275, 26358791" +OncoKB,ERBB2,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,23630663 +OncoKB,ERBB2,Likely Neutral,NA,COF,NA,NA,NA,NA,"18039657, 25720673" +OncoKB,ERBB2,Oncogenic,NA,GOF,NA,NA,NA,NA,17311002 +OncoKB,ERBB2,Oncogenic,NA,GOF,NA,NA,NA,NA,"24516025, 22046346, 23220880" +OncoKB,ERBB2,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"26619011, 22908275, 18772396, 18772890, 23389443" +OncoKB,ERBB2,Likely Neutral,NA,Likely LOF,NA,NA,NA,NA,23220880 +OncoKB,ERBB2,Oncogenic,NA,GOF,NA,NA,NA,NA,"25994018, 23220880" +OncoKB,ERBB2,Likely Neutral,NA,LOF,NA,NA,NA,NA,22908275 +OncoKB,ERBB2,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,18413839 +OncoKB,ERBB2,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,18413839 +OncoKB,ERBB2,Oncogenic,NA,GOF,NA,NA,NA,NA,26243863 +OncoKB,ERBB2,Oncogenic,NA,GOF,NA,NA,NA,NA,22046346 +OncoKB,ERBB2,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"18413839, 16397024" +OncoKB,ERBB2,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,18413839 +OncoKB,ERBB2,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,18413839 +OncoKB,ERBB2,Likely Neutral,NA,LOF,NA,NA,NA,NA,16489002 +OncoKB,ERBB2,Likely Oncogenic,NA,Likely SOF,NA,NA,NA,NA,"18413839, 28274957" +OncoKB,ERBB2,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"24971884, 23220880" +OncoKB,ERBB2,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,18413839 +OncoKB,ERBB2,Oncogenic,NA,GOF,NA,NA,NA,NA,22046346 +OncoKB,ERBB2,Oncogenic,NA,GOF,NA,NA,NA,NA,16843263 +OncoKB,ERBB2,Oncogenic,NA,GOF,NA,NA,NA,NA,"1671296, 7821711" +OncoKB,ERBB2,Oncogenic,NA,GOF,NA,NA,NA,NA,26545934 +OncoKB,ERBB3,Oncogenic,NA,GOF,NA,NA,NA,NA,23680147 +OncoKB,ERBB3,Oncogenic,NA,GOF,NA,NA,NA,NA,23680147 +OncoKB,ERBB3,Oncogenic,NA,GOF,NA,NA,NA,NA,23680147 +OncoKB,ERBB3,Oncogenic,NA,GOF,NA,NA,NA,NA,23680147 +OncoKB,ERBB3,Oncogenic,NA,GOF,NA,NA,NA,NA,23680147 +OncoKB,ERBB3,Oncogenic,NA,GOF,NA,NA,NA,NA,23680147 +OncoKB,ERBB3,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,23741632 +OncoKB,ERBB3,Oncogenic,NA,GOF,NA,NA,NA,NA,"20418034, 24886126, 25739551" +OncoKB,ERBB3,Oncogenic,NA,GOF,NA,NA,NA,NA,23680147 +OncoKB,ERBB3,Oncogenic,NA,GOF,NA,NA,NA,NA,23680147 +OncoKB,ERBB3,Oncogenic,NA,GOF,NA,NA,NA,NA,23680147 +OncoKB,ERBB3,Likely Neutral,NA,COF,NA,NA,NA,NA,23680147 +OncoKB,ERBB3,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,23741632 +OncoKB,ERBB4,Oncogenic,NA,GOF,NA,NA,NA,NA,19718025 +OncoKB,ERBB4,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,21701703 +OncoKB,ERBB4,Oncogenic,NA,GOF,NA,NA,NA,NA,26050618 +OncoKB,ERBB4,Oncogenic,NA,GOF,NA,NA,NA,NA,19718025 +OncoKB,ERBB4,Likely Neutral,NA,COF,NA,NA,NA,NA,26050618 +OncoKB,ERBB4,Oncogenic,NA,GOF,NA,NA,NA,NA,"24727320, 22327623" +OncoKB,ERBB4,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,25435280 +OncoKB,ERBB4,Likely Neutral,NA,COF,NA,NA,NA,NA,26050618 +OncoKB,ERBB4,Oncogenic,NA,GOF,NA,NA,NA,NA,26050618 +OncoKB,ERBB4,Oncogenic,NA,GOF,NA,NA,NA,NA,19718025 +OncoKB,ERBB4,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,26050618 +OncoKB,ERBB4,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,24727320 +OncoKB,ERBB4,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,25435280 +OncoKB,ERBB4,Likely Neutral,NA,COF,NA,NA,NA,NA,26050618 +OncoKB,ERBB4,Likely Neutral,NA,COF,NA,NA,NA,NA,26050618 +OncoKB,ERBB4,Oncogenic,NA,GOF,NA,NA,NA,NA,19718025 +OncoKB,ERBB4,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,26050618 +OncoKB,ERBB4,Oncogenic,NA,GOF,NA,NA,NA,NA,19718025 +OncoKB,ERBB4,Oncogenic,NA,GOF,NA,NA,NA,NA,19718025 +OncoKB,ERBB4,Oncogenic,NA,GOF,NA,NA,NA,NA,26050618 +OncoKB,ERBB4,Oncogenic,NA,GOF,NA,NA,NA,NA,19718025 +OncoKB,ERBB4,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,25435280 +OncoKB,ERCC2,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,27504877 +OncoKB,ERCC2,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,27504877 +OncoKB,ERCC2,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,27504877 +OncoKB,ERCC2,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,25096233 +OncoKB,ERCC2,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,27504877 +OncoKB,ERCC2,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,27504877 +OncoKB,ERCC2,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,25096233 +OncoKB,ERCC2,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,27504877 +OncoKB,ERCC2,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,25096233 +OncoKB,ERCC2,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,27504877 +OncoKB,ERCC2,Likely Neutral,NA,COF,NA,NA,NA,NA,27504877 +OncoKB,ERCC2,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,25096233 +OncoKB,ERCC2,Likely Neutral,NA,COF,NA,NA,NA,NA,27504877 +OncoKB,ERCC2,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,25096233 +OncoKB,ERCC2,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,25096233 +OncoKB,ERCC2,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,25096233 +OncoKB,ERCC2,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,25096233 +OncoKB,ERCC2,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,27504877 +OncoKB,ERCC2,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA, +OncoKB,ERCC2,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,25096233 +OncoKB,ERCC2,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,27504877 +OncoKB,ERCC2,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,27504877 +OncoKB,BRIP1,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"16153896, 24040146, 17033622, 21964575, 18628483" +OncoKB,BRIP1,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,"17145708, 11301010, 14983014" +OncoKB,BRIP1,Oncogenic,NA,LOF,NA,NA,NA,NA,12569564 +OncoKB,BRIP1,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"16153896, 17033622" +OncoKB,BRIP1,Oncogenic,NA,LOF,NA,NA,NA,NA,"11301010, 2846277, 8196650, 14983014" +OncoKB,BRIP1,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"20639400, 16116424" +OncoKB,BRIP1,Oncogenic,NA,LOF,NA,NA,NA,NA,"11301010, 14983014" +OncoKB,BRIP1,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"24040146, 21964575, 18628483" +OncoKB,ERCC3,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,27655433 +OncoKB,ERCC3,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"16143348, 19942596, 27655433, 8196650" +OncoKB,ERCC4,Oncogenic,NA,LOF,NA,NA,NA,NA,24027083 +OncoKB,ERCC4,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"9580660, 26074087, 23623386" +OncoKB,ERCC4,Oncogenic,NA,LOF,NA,NA,NA,NA,10499592 +OncoKB,ERCC4,Oncogenic,NA,LOF,NA,NA,NA,NA,23623386 +OncoKB,ERCC4,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"9580660, 8887684" +OncoKB,ERCC4,Oncogenic,NA,LOF,NA,NA,NA,NA,"24027083, 23623386" +OncoKB,ABL1,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"16046538, 21562040" +OncoKB,ABL1,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,16482207 +OncoKB,ABL1,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,24456693 +OncoKB,ABL1,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,21435002 +OncoKB,ABL1,Oncogenic,NA,GOF,NA,NA,NA,NA,16880519 +OncoKB,ABL1,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,19201023 +OncoKB,ABL1,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"23086624, 18242697" +OncoKB,ABL1,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,21562040 +OncoKB,ABL1,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"21562040, 16424036" +OncoKB,ABL1,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,21562040 +OncoKB,ABL1,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,19798095 +OncoKB,ABL1,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,21562040 +OncoKB,ABL1,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,21562040 +OncoKB,ABL1,Oncogenic,NA,GOF,NA,NA,NA,NA,15510211 +OncoKB,ABL1,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,21562040 +OncoKB,ABL1,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,21562040 +OncoKB,ABL1,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,21562040 +OncoKB,ABL1,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,21562040 +OncoKB,ABL1,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"18794843, 11423618" +OncoKB,ABL1,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,21562040 +OncoKB,ABL1,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,21562040 +OncoKB,ABL1,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"16046538, 21562040" +OncoKB,ABL1,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,23355941 +OncoKB,ABL1,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,21562040 +OncoKB,ABL1,Oncogenic,NA,GOF,NA,NA,NA,NA,"11345193, 18851712" +OncoKB,ABL1,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,21193419 +OncoKB,ABL1,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,15194504 +OncoKB,ABL1,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,21562040 +OncoKB,ABL1,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,21562040 +OncoKB,CEBPA,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"11830484, 19322763, 19651529, 18768433, 19075268" +OncoKB,ERF,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"21548782, 17699159, 17525531, 22198386" +OncoKB,ERG,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"19649210, 23625457, 20585344" +OncoKB,ERG,Oncogenic,NA,GOF,NA,NA,NA,NA,"22142399, 19396167, 18283340, 17043636" +OncoKB,ERG,Oncogenic,NA,GOF,NA,NA,NA,NA,"8187069, 7970732, 9653171, 25453903" +OncoKB,ERG,Oncogenic,NA,GOF,NA,NA,NA,NA,"16357154, 8162068, 25453903" +OncoKB,HLA-A,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,15546342 +OncoKB,HLA-A,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,16216676 +OncoKB,HLA-B,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"26889905, 19845903, 27807939, 14675390, 28205408" +OncoKB,PDGFRA,Likely Neutral,NA,COF,NA,NA,NA,NA,23752188 +OncoKB,PDGFRA,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,24132921 +OncoKB,PDGFRA,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,20889717 +OncoKB,PDGFRA,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,24132921 +OncoKB,PDGFRA,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,15928335 +OncoKB,PDGFRA,Oncogenic,NA,GOF,NA,NA,NA,NA,23970477 +OncoKB,PDGFRA,Oncogenic,NA,GOF,NA,NA,NA,NA,23970477 +OncoKB,PDGFRA,Oncogenic,NA,GOF,NA,NA,NA,NA,"15928335, 12522257" +OncoKB,PDGFRA,Likely Neutral,NA,COF,NA,NA,NA,NA,23752188 +OncoKB,PDGFRA,Likely Neutral,NA,COF,NA,NA,NA,NA,21224473 +OncoKB,PDGFRA,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,"12023981, 12944919, 15034867" +OncoKB,PDGFRA,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,22745105 +OncoKB,PDGFRA,Likely Neutral,NA,COF,NA,NA,NA,NA,24132921 +OncoKB,PDGFRA,Oncogenic,NA,GOF,NA,NA,NA,NA,"20889717, 16690743" +OncoKB,PDGFRA,Oncogenic,NA,GOF,NA,NA,NA,NA,"16754777, 19187542, 16645167, 24057647, 12660384, 16690743, 24407160, 16608506, 21224473, 19212337, 12781364, 27021554, 16030188" +OncoKB,PDGFRA,Likely Neutral,NA,Likely LOF,NA,NA,NA,NA,23752188 +OncoKB,PDGFRA,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,22745105 +OncoKB,PDGFRA,Likely Neutral,NA,COF,NA,NA,NA,NA,23752188 +OncoKB,PDGFRA,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,24132921 +OncoKB,PDGFRA,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,"25975287, 17087943" +OncoKB,PDGFRA,Oncogenic,NA,GOF,NA,NA,NA,NA,16845659 +OncoKB,PDGFRA,Oncogenic,NA,GOF,NA,NA,NA,NA,23970477 +OncoKB,PDGFRA,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,24132921 +OncoKB,PDGFRA,Oncogenic,NA,GOF,NA,NA,NA,NA,23970477 +OncoKB,PDGFRA,Likely Neutral,NA,COF,NA,NA,NA,NA,23752188 +OncoKB,PDGFRA,Likely Neutral,NA,COF,NA,NA,NA,NA,21224473 +OncoKB,PDGFRA,Oncogenic,NA,GOF,NA,NA,NA,NA,"15928335, 12522257, 22745105" +OncoKB,PDGFRA,Oncogenic,NA,GOF,NA,NA,NA,NA,21224473 +OncoKB,PDGFRA,Likely Neutral,NA,COF,NA,NA,NA,NA,"22733151, 12949711, 19366796" +OncoKB,PDGFRA,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,15928335 +OncoKB,PDGFRA,Oncogenic,NA,GOF,NA,NA,NA,NA,"17087936, 12949711, 15928335, 19217431, 12522257, 18955458, 22665524, 22745105" +OncoKB,PDGFRA,Oncogenic,NA,GOF,NA,NA,NA,NA,23970477 +OncoKB,PDGFRA,Oncogenic,NA,Likely GOF,NA,NA,NA,NA,24132921 +OncoKB,PDGFRA,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,21224473 +OncoKB,PDGFRA,Oncogenic,NA,GOF,NA,NA,NA,NA,17555450 +OncoKB,PDGFRA,Oncogenic,NA,GOF,NA,NA,NA,NA,"17555450, 16498388" +OncoKB,PDGFRA,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,24132921 +OncoKB,PDGFRA,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,22745105 +OncoKB,PDGFRA,Oncogenic,NA,GOF,NA,NA,NA,NA,23752188 +OncoKB,PDGFRA,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,"15928335, 24132921, 22745105" +OncoKB,PDGFRA,Likely Neutral,NA,LOF,NA,NA,NA,NA,23752188 +OncoKB,PDGFRA,Oncogenic,NA,GOF,NA,NA,NA,NA,"15928335, 22745105" +OncoKB,PDGFRA,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,"15928335, 12522257" +OncoKB,PDGFRA,Likely Neutral,NA,COF,NA,NA,NA,NA,24132921 +OncoKB,PDGFRA,Likely Neutral,NA,COF,NA,NA,NA,NA,21224473 +OncoKB,PDGFRA,Oncogenic,NA,GOF,NA,NA,NA,NA,22745105 +OncoKB,PDGFRA,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,"15928335, 22745105" +OncoKB,PDGFRA,Oncogenic,NA,GOF,NA,NA,NA,NA,"20889717, 12569364" +OncoKB,PDGFRA,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,21224473 +OncoKB,PDGFRA,Likely Neutral,NA,COF,NA,NA,NA,NA,23752188 +OncoKB,PDGFRA,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,"15146165, 15928335" +OncoKB,PDGFRA,Oncogenic,NA,GOF,NA,NA,NA,NA,24132921 +OncoKB,PDGFRA,Likely Neutral,NA,COF,NA,NA,NA,NA,"24057647, 21224473" +OncoKB,PDGFRA,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,"15928335, 22745105" +OncoKB,PDGFRA,Oncogenic,NA,GOF,NA,NA,NA,NA,"21931021, 20685895, 18772890, 22745105, 16357008" +OncoKB,PDGFRA,Oncogenic,NA,GOF,NA,NA,NA,NA,26396737 +OncoKB,PDGFRA,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,24132921 +OncoKB,PDGFRA,Oncogenic,NA,GOF,NA,NA,NA,NA,"24132921, 22665524, 23752188, 18794084, 17087936, 12949711, 15928335, 23970477, 19217431, 12522257, 18955458, 22745105, 15685537, 16030188" +OncoKB,PDGFRA,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,24132921 +OncoKB,PDGFRA,Likely Neutral,NA,COF,NA,NA,NA,NA,24132921 +OncoKB,PDGFRA,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,15928335 +OncoKB,PDGFRA,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,"18955458, 22745105" +OncoKB,PDGFRA,Oncogenic,NA,GOF,NA,NA,NA,NA,21224473 +OncoKB,PDGFRA,Oncogenic,NA,GOF,NA,NA,NA,NA,17555450 +OncoKB,PDGFRA,Oncogenic,NA,GOF,NA,NA,NA,NA,24132921 +OncoKB,PDGFRA,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,18794084 +OncoKB,PDGFRA,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,23752188 +OncoKB,PDGFRB,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"17296564, 18262053" +OncoKB,PDGFRB,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,12907457 +OncoKB,PDGFRB,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,18262053 +OncoKB,PDGFRB,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,15087377 +OncoKB,PDGFRB,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,23731537 +OncoKB,PDGFRB,Oncogenic,NA,GOF,NA,NA,NA,NA,9616134 +OncoKB,PDGFRB,Oncogenic,NA,GOF,NA,NA,NA,NA,11588050 +OncoKB,PDGFRB,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,"18515258, 18157090, 18612157, 16630177, 21729646, 18670317" +OncoKB,PDGFRB,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,8168137 +OncoKB,PDGFRB,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,15492236 +OncoKB,PDGFRB,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"17296564, 18262053" +OncoKB,PDGFRB,Likely Neutral,NA,LOF,NA,NA,NA,NA,"23255827, 26599395" +OncoKB,PDGFRB,Likely Neutral,NA,Likely LOF,NA,NA,NA,NA,"23255827, 26599395" +OncoKB,PDGFRB,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,23731542 +OncoKB,PDGFRB,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,12907457 +OncoKB,PDGFRB,Oncogenic,NA,GOF,NA,NA,NA,NA,"22271894, 8168137, 19644140, 19100521" +OncoKB,PDGFRB,Oncogenic,NA,GOF,NA,NA,NA,NA,21685469 +OncoKB,PDGFRB,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,20085582 +OncoKB,PDGFRB,Likely Neutral,NA,Likely LOF,NA,NA,NA,NA,"23255827, 26599395" +OncoKB,PDGFRB,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,20085582 +OncoKB,PDGFRB,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"20581310, 8962143, 19806146, 22271894, 8168137, 22897847, 18483217" +OncoKB,PDGFRB,Oncogenic,NA,GOF,NA,NA,NA,NA,"24186319, 8168137, 22897847, 23835704" +OncoKB,PDGFRB,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,17296564 +OncoKB,PDGFRB,Oncogenic,NA,LOF,NA,NA,NA,NA,26279204 +OncoKB,PDGFRB,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,20085582 +OncoKB,PDGFRB,Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"23186533, 15492236" +OncoKB,RBM10,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"26853560, 24000153, 24332178" +OncoKB,RBM10,Oncogenic,NA,LOF,NA,NA,NA,NA,"20007775, 24332178" +OncoKB,RBM10,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"21910224, 24000153, 22980975, 25079552, 24332178" +OncoKB,KDM5C,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,25666439 +OncoKB,KDM5C,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,25666439 +OncoKB,KDM5C,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,25666439 +OncoKB,KDM5C,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,25016185 +OncoKB,KDM5C,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA, +OncoKB,KDM5C,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,25666439 +OncoKB,ESR1,Likely Neutral,NA,COF,NA,NA,NA,NA,27986707 +OncoKB,ESR1,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,"24185512, 24398047, 24185510, 9102207, 11322512, 9500442" +OncoKB,ESR1,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,"10787412, 9234721, 1630819, 9774463, 15282324" +OncoKB,ESR1,Oncogenic,NA,GOF,NA,NA,NA,NA,27986707 +OncoKB,ESR1,Oncogenic,NA,GOF,NA,NA,NA,NA,"24185512, 24185510, 26836308, 27986707, 8923465, 9398213, 11914066" +OncoKB,ESR1,Oncogenic,NA,GOF,NA,NA,NA,NA,"25099679, 22496636, 22101766" +OncoKB,ESR1,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,27986707 +OncoKB,ESR1,Oncogenic,NA,GOF,NA,NA,NA,NA,24055055 +OncoKB,ESR1,Likely Neutral,NA,COF,NA,NA,NA,NA,27986707 +OncoKB,ESR1,Oncogenic,NA,GOF,NA,NA,NA,NA,"24185512, 24398047, 24185510, 24217577, 1630819, 26836308, 15282324" +OncoKB,ESR1,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,"24185512, 1630819, 15282324" +OncoKB,ESR1,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,"9259327, 1630819, 8114756, 15282324" +OncoKB,ESR1,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"24185512, 1630819, 15282324" +OncoKB,ESR1,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,"24185510, 1630819, 15282324" +OncoKB,ESR1,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,"1630819, 15282324, 15159406" +OncoKB,ESR1,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,"24398047, 24185510, 1630819, 11322512, 9500442, 15282324" +OncoKB,ESR1,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,"1630819, 27986707, 15282324" +OncoKB,ESR1,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"25099679, 24055055" +OncoKB,ETV1,Oncogenic,NA,GOF,NA,NA,NA,NA,"16357154, 7700648, 25453903" +OncoKB,ETV1,Oncogenic,NA,GOF,NA,NA,NA,NA,"23908683, 20160028" +OncoKB,ETV1,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"23814484, 21298110, 18794142, 23625457, 17671502" +OncoKB,ETV1,Oncogenic,NA,GOF,NA,NA,NA,NA,"18563191, 23512661" +OncoKB,ETV6,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"25581430, 26522332, 27365488" +OncoKB,ETV6,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,25807284 +OncoKB,ETV6,Oncogenic,NA,GOF,NA,NA,NA,NA,"21804605, 18068631, 21148487" +OncoKB,ETV6,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,25807284 +OncoKB,ETV6,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"25581430, 26522332, 26102509, 27365488" +OncoKB,ETV6,Oncogenic,NA,GOF,NA,NA,NA,NA,16761019 +OncoKB,ETV6,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,25807284 +OncoKB,ETV6,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"12173038, 10702799, 22578774" +OncoKB,TSC1,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"23485365, 24529379, 20301399" +OncoKB,TSC1,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,18397877 +OncoKB,TSC1,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,18397877 +OncoKB,TSC1,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,18830229 +OncoKB,TSC1,Likely Neutral,NA,COF,NA,NA,NA,NA,18830229 +OncoKB,TSC1,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,18830229 +OncoKB,TSC1,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,18830229 +OncoKB,TSC1,Likely Neutral,NA,COF,NA,NA,NA,NA,18830229 +OncoKB,TSC1,Oncogenic,NA,LOF,NA,NA,NA,NA,18830229 +OncoKB,TSC1,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,18397877 +OncoKB,TSC1,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,"18830229, 11781698, 17304050" +OncoKB,TSC1,Likely Neutral,NA,COF,NA,NA,NA,NA,18830229 +OncoKB,TSC1,Likely Neutral,NA,COF,NA,NA,NA,NA,"18397877, 10570911, 10607950" +OncoKB,TSC1,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,22923433 +OncoKB,TSC1,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,18397877 +OncoKB,TSC1,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,18397877 +OncoKB,TSC1,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,18397877 +OncoKB,TSC1,Likely Neutral,NA,COF,NA,NA,NA,NA,18830229 +OncoKB,TSC1,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"23485365, 24529379, 11741833, 10353610" +OncoKB,TSC1,Likely Neutral,NA,COF,NA,NA,NA,NA,"23857276, 21309039" +OncoKB,TSC1,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,18830229 +OncoKB,TSC1,Likely Neutral,NA,COF,NA,NA,NA,NA,18830229 +OncoKB,TSC1,Likely Neutral,NA,COF,NA,NA,NA,NA,18830229 +OncoKB,IKZF1,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,"27067989, 19129520, 27815723, 26202931" +OncoKB,TSC2,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"24529379, 14729330, 25724664, 14561707" +OncoKB,TSC2,Oncogenic,NA,LOF,NA,NA,NA,NA,22903760 +OncoKB,TSC2,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,22903760 +OncoKB,TSC2,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,22903760 +OncoKB,TSC2,Oncogenic,NA,LOF,NA,NA,NA,NA,22903760 +OncoKB,TSC2,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,22903760 +OncoKB,TSC2,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"15483652, 11741832" +OncoKB,TSC2,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,22903760 +OncoKB,TSC2,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,22903760 +OncoKB,TSC2,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,17120248 +OncoKB,TSC2,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,22903760 +OncoKB,TSC2,Oncogenic,NA,LOF,NA,NA,NA,NA,22903760 +OncoKB,TSC2,Oncogenic,NA,LOF,NA,NA,NA,NA,22903760 +OncoKB,TSC2,Oncogenic,NA,LOF,NA,NA,NA,NA,22903760 +OncoKB,TSC2,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,22903760 +OncoKB,TSC2,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,15972957 +OncoKB,TSC2,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,22903760 +OncoKB,TSC2,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,22903760 +OncoKB,TSC2,Oncogenic,NA,LOF,NA,NA,NA,NA,22903760 +OncoKB,TSC2,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,22903760 +OncoKB,TSC2,Oncogenic,NA,LOF,NA,NA,NA,NA,22903760 +OncoKB,TSC2,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,22903760 +OncoKB,TSC2,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,22903760 +OncoKB,TSC2,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,17120248 +OncoKB,TSC2,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"22903760, 27493206" +OncoKB,TSC2,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,22903760 +OncoKB,TSC2,Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"11281455, 25724664, 26540169, 25281918, 14561707" +OncoKB,TSC2,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,"15483652, 11741832" +OncoKB,TSC2,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,22903760 +OncoKB,TSC2,Oncogenic,NA,LOF,NA,NA,NA,NA,22903760 +OncoKB,TSC2,Oncogenic,NA,LOF,NA,NA,NA,NA,22903760 +OncoKB,TSC2,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,22903760 +OncoKB,TSC2,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,"15483652, 11741832" +OncoKB,TSC2,Oncogenic,NA,LOF,NA,NA,NA,NA,22903760 +OncoKB,TSC2,Oncogenic,NA,LOF,NA,NA,NA,NA,22903760 +OncoKB,TSC2,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,21332470 +OncoKB,TSC2,Oncogenic,NA,LOF,NA,NA,NA,NA,22903760 +OncoKB,TSC2,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"15483652, 22903760" +OncoKB,TSC2,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,22903760 +OncoKB,TSC2,Oncogenic,NA,LOF,NA,NA,NA,NA,22903760 +OncoKB,TSC2,Oncogenic,NA,LOF,NA,NA,NA,NA,22903760 +OncoKB,TSC2,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,"11290735, 22903760, 12205112" +OncoKB,TSC2,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,17120248 +OncoKB,TSC2,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,21332470 +OncoKB,TSC2,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,22903760 +OncoKB,TSC2,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,22903760 +OncoKB,TSC2,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,22903760 +OncoKB,TSC2,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,"15483652, 11741832" +OncoKB,TSC2,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,"15483652, 11741832" +OncoKB,TSC2,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,"15483652, 11741832" +OncoKB,TSC2,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,22903760 +OncoKB,TSC2,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,22903760 +OncoKB,EWSR1,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"24320889, 21822206, 25364450, 19801966" +OncoKB,EWSR1,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"24320889, 21822206, 25364450, 19801966" +OncoKB,EWSR1,Oncogenic,NA,GOF,NA,NA,NA,NA,"9591781, 11278460, 10999739, 11237525, 24321497" +OncoKB,EWSR1,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,8605035 +OncoKB,EWSR1,Oncogenic,NA,GOF,NA,NA,NA,NA,25109552 +OncoKB,EWSR1,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,9121764 +OncoKB,EWSR1,Oncogenic,NA,GOF,NA,NA,NA,NA,"24320889, 7805034, 24790523" +OncoKB,EWSR1,Oncogenic,NA,GOF,NA,NA,NA,NA,"18500345, 8162068, 10749119" +OncoKB,EWSR1,Oncogenic,NA,GOF,NA,NA,NA,NA,23630070 +OncoKB,EWSR1,Oncogenic,NA,GOF,NA,NA,NA,NA,"22592656, 16604165" +OncoKB,EWSR1,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"8605035, 23329308, 21113140, 8834175" +OncoKB,EWSR1,Oncogenic,NA,GOF,NA,NA,NA,NA,"17250957, 22930730, 24320889, 11715049, 25453903, 12432241" +OncoKB,ACVR1,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,"24705254, 20463014, 22977237, 24769718" +OncoKB,ACVR1,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"24705254, 20463014, 22977237, 24769718" +OncoKB,ACVR1,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,"24705254, 20463014, 24705250, 24769718" +OncoKB,ACVR1,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,24852373 +OncoKB,FOXA1,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,22722839 +OncoKB,FOXA1,Oncogenic,NA,GOF,NA,NA,NA,NA,"22138582, 19470727, 22722839, 21147910, 22960745, 23622249, 19372580, 2298097, 23539448, 25079552, 12234996" +OncoKB,FOXA1,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,23539448 +OncoKB,FOXA1,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"22722839, 23539448" +OncoKB,FOXA1,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,22722839 +OncoKB,FOXA1,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,22722839 +OncoKB,FOXA1,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,22722839 +OncoKB,FOXA1,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,24840332 +OncoKB,MDM2,Oncogenic,NA,GOF,NA,NA,NA,NA,"9671804, 24667108, 15199139, 27194168" +OncoKB,ARID1A,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"21900401, 24899687, 25625625" +OncoKB,ARID1A,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,"22249247, 23097632, 21412130, 23208470" +OncoKB,EZH2,Oncogenic,NA,GOF,NA,NA,NA,NA,"16330673, 12374981, 14500907, 21837672" +OncoKB,EZH2,Likely Oncogenic,NA,SOF,NA,NA,NA,NA,22323599 +OncoKB,EZH2,Oncogenic,NA,SOF,NA,NA,NA,NA,"21078963, 21190999" +OncoKB,EZH2,Oncogenic,NA,SOF,NA,NA,NA,NA,"21078963, 21190999, 24469040, 21810159, 21843048" +OncoKB,EZH2,Oncogenic,NA,SOF,NA,NA,NA,NA,"21078963, 21190999, 27135738, 24469040, 21810159, 21843048" +OncoKB,EZH2,Oncogenic,NA,GOF,NA,NA,NA,NA,"16330673, 12374981, 14500907, 21837672" +OncoKB,EZH2,Oncogenic,NA,SOF,NA,NA,NA,NA,"21078963, 21190999" +OncoKB,EZH2,Oncogenic,NA,SOF,NA,NA,NA,NA,"21078963, 21190999" +OncoKB,MDM4,Oncogenic,NA,LOF,NA,NA,NA,NA,"15199139, 9131587" +OncoKB,MDM4,Oncogenic,NA,GOF,NA,NA,NA,NA,"9523192, 15199139, 7585611" +OncoKB,KLF4,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,23404370 +OncoKB,RXRA,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,24476821 +OncoKB,RXRA,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,24476821 +OncoKB,MAP3K1,Likely Oncogenic,NA,Inconclusive,NA,NA,NA,NA,"24003131, 24386504" +OncoKB,MAP3K1,Likely Neutral,NA,COF,NA,NA,NA,NA,25899310 +OncoKB,MAP3K1,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,25899310 +OncoKB,MAP3K1,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,25899310 +OncoKB,AXIN1,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"10700176, 25236910" +OncoKB,AXIN2,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"15802015, 17373666" +OncoKB,BAP1,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"21874000, 26246155, 24633195, 25970771" +OncoKB,BAP1,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,26680512 +OncoKB,BAP1,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,26680512 +OncoKB,BAP1,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"21874000, 18757409" +OncoKB,BAP1,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,25830670 +OncoKB,BAP1,Oncogenic,NA,LOF,NA,NA,NA,NA,"19815555, 9528852" +OncoKB,BAP1,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,18757409 +OncoKB,BAP1,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,26081045 +OncoKB,BAP1,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,"26680512, 24894717, 18757409" +OncoKB,BAP1,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,"24894717, 18757409" +OncoKB,MEN1,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA, +OncoKB,MEN1,Oncogenic,NA,LOF,NA,NA,NA,NA,"12746426, 27076911, 9510467, 16740708, 21627674, 14633735, 12941803" +OncoKB,FANCA,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"15522956, 12637330, 24689079, 8374893, 12827451, 14749703" +OncoKB,FANCA,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,16720839 +OncoKB,FANCA,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,12955722 +OncoKB,FANCA,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,16720839 +OncoKB,FANCA,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,16720839 +OncoKB,FANCA,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"21273304, 15522956, 24689079, 12827451" +OncoKB,FANCA,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,"16720839, 12444097" +OncoKB,FANCA,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA, +OncoKB,FANCA,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,16720839 +OncoKB,FANCA,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,"10468606, 11050007, 11161829" +OncoKB,FANCC,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"11520787, 16687415, 20509860" +OncoKB,MET,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,"9826708, 18709663" +OncoKB,MET,Oncogenic,NA,GOF,NA,NA,NA,NA,9563489 +OncoKB,MET,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"27666659, 14559814, 16227611, 25898965, 25971938, 15735036, 27343443, 16397241, 26892698, 19096300" +OncoKB,MET,Oncogenic,NA,GOF,NA,NA,NA,NA,"15735036, 16397241, 19096300" +OncoKB,MET,Oncogenic,NA,GOF,NA,NA,NA,NA,"15064724, 24061647" +OncoKB,MET,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,19318576 +OncoKB,MET,Oncogenic,NA,GOF,NA,NA,NA,NA,"15735036, 16397241, 19096300" +OncoKB,MET,Oncogenic,NA,GOF,NA,NA,NA,NA,"15064724, 24061647" +OncoKB,MET,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,"25605252, 14559814, 21970370, 11042681, 22973954, 15735036, 17322284" +OncoKB,MET,Oncogenic,NA,GOF,NA,NA,NA,NA,12460923 +OncoKB,MET,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,19783361 +OncoKB,MET,Oncogenic,NA,GOF,NA,NA,NA,NA,"16227611, 15123609, 11741535" +OncoKB,MET,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,10327054 +OncoKB,MET,Oncogenic,NA,GOF,NA,NA,NA,NA,"15735036, 16397241, 19096300" +OncoKB,MET,Oncogenic,NA,GOF,NA,NA,NA,NA,"10327054, 10871851, 9826715, 15557554" +OncoKB,MET,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"16227611, 15123609, 11741535" +OncoKB,MET,Oncogenic,NA,GOF,NA,NA,NA,NA,"27666659, 9826708, 9326629" +OncoKB,MET,Oncogenic,NA,GOF,NA,NA,NA,NA,"15064724, 24061647" +OncoKB,MET,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,25135958 +OncoKB,MET,Oncogenic,NA,GOF,NA,NA,NA,NA,"24173966, 21697284" +OncoKB,MET,Oncogenic,NA,GOF,NA,NA,NA,NA,"16461907, 20129249, 19117057, 17667909, 22869872, 18077425, 17463250" +OncoKB,MET,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"27666659, 14559814, 16227611, 25898965, 25971938, 15735036, 27343443, 16397241, 19096300" +OncoKB,MET,Oncogenic,NA,GOF,NA,NA,NA,NA,"15735036, 16397241, 19096300" +OncoKB,MET,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,"20670955, 14559814, 22973954" +OncoKB,MET,Oncogenic,NA,GOF,NA,NA,NA,NA,"12460923, 10734314" +OncoKB,MET,Oncogenic,NA,GOF,NA,NA,NA,NA,"19783361, 24061647" +OncoKB,MET,Oncogenic,NA,GOF,NA,NA,NA,NA,"15735036, 16397241, 19096300" +OncoKB,MET,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,26892698 +OncoKB,MET,Oncogenic,NA,GOF,NA,NA,NA,NA,"9554529, 9870683, 8077049, 11381087, 15375530, 10698493" +OncoKB,MET,Oncogenic,NA,GOF,NA,NA,NA,NA,25401301 +OncoKB,MET,Oncogenic,NA,GOF,NA,NA,NA,NA,"24061647, 10417759" +OncoKB,MET,Oncogenic,NA,GOF,NA,NA,NA,NA,"15735036, 16397241, 19096300" +OncoKB,MET,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"9826708, 27343442" +OncoKB,MET,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,"16171945, 19723643" +OncoKB,MET,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"25079552, 16397241" +OncoKB,MET,Oncogenic,NA,GOF,NA,NA,NA,NA,"15735036, 16397241, 19096300" +OncoKB,U2AF1,Oncogenic,NA,SOF,NA,NA,NA,NA,"25267526, 25311244" +OncoKB,U2AF1,Likely Oncogenic,NA,SOF,NA,NA,NA,NA,"25267526, 25311244" +OncoKB,U2AF1,Oncogenic,NA,SOF,NA,NA,NA,NA,"22158538, 25267526, 25311244" +OncoKB,U2AF1,Likely Oncogenic,NA,SOF,NA,NA,NA,NA,"25965570, 22158538, 25267526, 25311244" +OncoKB,KMT2C,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"23166019, 11891048, 24081332, 24794707, 9834205" +OncoKB,KMT2C,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"23259788, 19433796, 25537518" +OncoKB,KMT2C,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,"25998713, 25151357" +OncoKB,KMT2C,Likely Neutral,NA,COF,NA,NA,NA,NA,24965397 +OncoKB,PARP1,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA, +OncoKB,FAT1,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,23354438 +OncoKB,FAT1,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,23354438 +OncoKB,FAT1,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,23354438 +OncoKB,FAT1,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"24718888, 26905694, 23354438" +OncoKB,FAT1,Oncogenic,NA,LOF,NA,NA,NA,NA,"21617878, 23354438" +OncoKB,ARID1B,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"23660946, 22233809, 26340334" +OncoKB,ARID1B,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"23202128, 25674384, 26340334" +OncoKB,PIK3CA,Oncogenic,NA,GOF,NA,NA,NA,NA,"20593314, 21266528, 26627007" +OncoKB,PIK3CA,Oncogenic,NA,GOF,NA,NA,NA,NA,"18074223, 20593314, 22949682, 17376864" +OncoKB,PIK3CA,Oncogenic,NA,GOF,NA,NA,NA,NA,26627007 +OncoKB,PIK3CA,Oncogenic,NA,GOF,NA,NA,NA,NA,"22120714, 17376864" +OncoKB,PIK3CA,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,22949682 +OncoKB,PIK3CA,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"25915946, 21266528" +OncoKB,PIK3CA,Oncogenic,NA,GOF,NA,NA,NA,NA,17376864 +OncoKB,PIK3CA,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,"17990317, 25054828, 22553375, 25401499" +OncoKB,PIK3CA,Oncogenic,NA,GOF,NA,NA,NA,NA,"20593314, 26627007" +OncoKB,PIK3CA,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"20593314, 21266528" +OncoKB,PIK3CA,Likely Neutral,NA,COF,NA,NA,NA,NA,26627007 +OncoKB,PIK3CA,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,23619167 +OncoKB,PIK3CA,Oncogenic,NA,GOF,NA,NA,NA,NA,"18074223, 21266528, 22949682" +OncoKB,PIK3CA,Oncogenic,NA,GOF,NA,NA,NA,NA,"17626883, 17376864" +OncoKB,PIK3CA,Oncogenic,NA,GOF,NA,NA,NA,NA,"15930273, 20593314, 17376864" +OncoKB,PIK3CA,Oncogenic,NA,GOF,NA,NA,NA,NA,"20593314, 26627007, 22120714, 17376864" +OncoKB,PIK3CA,Likely Neutral,NA,COF,NA,NA,NA,NA,26627007 +OncoKB,PIK3CA,Oncogenic,NA,GOF,NA,NA,NA,NA,"20593314, 26627007, 17376864" +OncoKB,PIK3CA,Oncogenic,NA,GOF,NA,NA,NA,NA,"27126994, 17376864" +OncoKB,PIK3CA,Oncogenic,NA,GOF,NA,NA,NA,NA,"20593314, 26627007, 17376864" +OncoKB,PIK3CA,Oncogenic,NA,GOF,NA,NA,NA,NA,17376864 +OncoKB,PIK3CA,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,27126994 +OncoKB,PIK3CA,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"18074223, 21266528, 26627007, 22949682, 17376864" +OncoKB,PIK3CA,Likely Neutral,NA,COF,NA,NA,NA,NA,18074223 +OncoKB,PIK3CA,Likely Neutral,NA,COF,NA,NA,NA,NA,"18074223, 17376864" +OncoKB,PIK3CA,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,21266528 +OncoKB,PIK3CA,Oncogenic,NA,GOF,NA,NA,NA,NA,"20593314, 16432179, 26627007, 17376864" +OncoKB,PIK3CA,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,21266528 +OncoKB,PIK3CA,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,17363507 +OncoKB,PIK3CA,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,"27007084, 17050665, 24718026" +OncoKB,PIK3CA,Oncogenic,NA,GOF,NA,NA,NA,NA,26627007 +OncoKB,PIK3CA,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"15930273, 20593314" +OncoKB,PIK3CA,Likely Neutral,NA,COF,NA,NA,NA,NA,20530683 +OncoKB,PIK3CA,Oncogenic,NA,GOF,NA,NA,NA,NA,26627007 +OncoKB,PIK3CA,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,24265155 +OncoKB,PIK3CA,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"20593314, 21266528" +OncoKB,PIK3CA,Oncogenic,NA,GOF,NA,NA,NA,NA,"20593314, 26627007, 17376864" +OncoKB,PIK3CA,Likely Neutral,NA,COF,NA,NA,NA,NA,17376864 +OncoKB,PIK3CA,Oncogenic,NA,GOF,NA,NA,NA,NA,"16322248, 19029981, 22960745, 16341083, 22214849, 16432179, 26627007, 21822287, 27126994, 25079552, 22120714, 21324922, 23940356, 25631445, 20593314, 22941189, 22370636, 23787421, 23636398, 17376864" +OncoKB,PIK3CA,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,"20593314, 21266528, 27126994" +OncoKB,PIK3CA,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,19394761 +OncoKB,PIK3CA,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,18829572 +OncoKB,PIK3CA,Oncogenic,NA,GOF,NA,NA,NA,NA,17376864 +OncoKB,PIK3CA,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,21266528 +OncoKB,PIK3CA,Oncogenic,NA,GOF,NA,NA,NA,NA,"16322248, 20593314, 16432179, 26627007, 17376864" +OncoKB,PIK3CA,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,19394761 +OncoKB,PIK3CA,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,"20593314, 21266528, 22949682" +OncoKB,PIK3CA,Likely Neutral,NA,COF,NA,NA,NA,NA,23619167 +OncoKB,PIK3CA,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,"15930273, 21266528" +OncoKB,PIK3CA,Oncogenic,NA,GOF,NA,NA,NA,NA,20530683 +OncoKB,PIK3CA,Oncogenic,NA,GOF,NA,NA,NA,NA,"18074223, 21266528, 22949682" +OncoKB,PIK3CA,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"20593314, 26627007" +OncoKB,PIK3CA,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"27555788, 15930273, 21266528" +OncoKB,PIK3CA,Likely Neutral,NA,COF,NA,NA,NA,NA,"27465249, 22430209" +OncoKB,PIK3CA,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,27126994 +OncoKB,PIK3CA,Oncogenic,NA,GOF,NA,NA,NA,NA,"17626883, 26627007" +OncoKB,PIK3CA,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"22228622, 22729224" +OncoKB,PIK3CA,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"21720365, 22960745, 17992665, 23136191, 19706770, 22292935, 22994622, 19697359, 25631445, 24608574, 26876212, 23636398, 27095573, 17803655" +OncoKB,PIK3CA,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,21703185 +OncoKB,PIK3CA,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"16432179, 26627007, 17376864" +OncoKB,PIK3CA,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,17376864 +OncoKB,PIK3CA,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,22949682 +OncoKB,PIK3CB,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"18755892, 26000489" +OncoKB,PIK3CB,Oncogenic,NA,GOF,NA,NA,NA,NA,25982275 +OncoKB,PIK3CB,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"18755892, 26000489" +OncoKB,PIK3CB,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,16339315 +OncoKB,PIK3CB,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"23734178, 20668451" +OncoKB,PIK3CB,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,26759240 +OncoKB,PIK3CB,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"26000489, 16432180" +OncoKB,PIK3CB,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"18755892, 26000489" +OncoKB,PIK3CB,Oncogenic,NA,GOF,NA,NA,NA,NA,26759240 +OncoKB,PIK3CB,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"26000489, 16432180" +OncoKB,PIK3CB,Oncogenic,NA,GOF,NA,NA,NA,NA,"24418330, 26442967, 16432180, 25533673" +OncoKB,PIM1,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,23755147 +OncoKB,PIM1,Likely Neutral,NA,COF,NA,NA,NA,NA,15808862 +OncoKB,PIM1,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,15808862 +OncoKB,PIM1,Likely Neutral,NA,Likely LOF,NA,NA,NA,NA,15808862 +OncoKB,PIM1,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,15808862 +OncoKB,PIM1,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,23755147 +OncoKB,PIM1,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,23755147 +OncoKB,PIM1,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,15808862 +OncoKB,PIM1,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,"23755147, 15808862, 19734423" +OncoKB,PIK3CD,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,"24136356, 24165795" +OncoKB,PIK3CD,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,"24136356, 24165795" +OncoKB,PIK3CD,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,24165795 +OncoKB,YAP1,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"23737213, 25965568, 24553141" +OncoKB,YAP1,Oncogenic,NA,GOF,NA,NA,NA,NA,"16140918, 15586366, 16814713, 24336504, 19952108, 15824737, 8569172, 10092132, 17114655, 20842732, 23502453, 24511017, 12651874, 12208731, 19551889" +OncoKB,YAP1,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,25965575 +OncoKB,YAP1,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,25965575 +OncoKB,YAP1,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,23737213 +OncoKB,PIK3R1,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,24367658 +OncoKB,PIK3R1,Oncogenic,NA,LOF,NA,NA,NA,NA,20713702 +OncoKB,PIK3R1,Oncogenic,NA,LOF,NA,NA,NA,NA,"21478295, 25284480, 21984976" +OncoKB,PIK3R1,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"24229379, 25488983, 25133428" +OncoKB,PIK3R1,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,24367658 +OncoKB,PIK3R1,Oncogenic,NA,LOF,NA,NA,NA,NA,20713702 +OncoKB,PIK3R1,Oncogenic,NA,LOF,NA,NA,NA,NA,19962665 +OncoKB,PIK3R1,Oncogenic,NA,LOF,NA,NA,NA,NA,20713702 +OncoKB,PIK3R1,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,20713702 +OncoKB,PIK3R1,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,24367658 +OncoKB,PIK3R1,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,"25488983, 25133428" +OncoKB,PIK3R1,Oncogenic,NA,LOF,NA,NA,NA,NA,24367658 +OncoKB,PIK3R1,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,20713702 +OncoKB,PIK3R1,Oncogenic,NA,LOF,NA,NA,NA,NA,"25957691, 21984976" +OncoKB,PIK3R1,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,20713702 +OncoKB,PIK3R1,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,"25488983, 25133428" +OncoKB,PIK3R1,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,24367658 +OncoKB,PIK3R1,Oncogenic,NA,LOF,NA,NA,NA,NA,20713702 +OncoKB,PIK3R1,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,24367658 +OncoKB,PIK3R1,Oncogenic,NA,LOF,NA,NA,NA,NA,"25284480, 21984976" +OncoKB,PIK3R1,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"25488983, 25284480, 25133428" +OncoKB,PIK3R1,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"25488983, 25284480, 25133428" +OncoKB,PIK3R1,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,20713702 +OncoKB,PIK3R1,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,24367658 +OncoKB,PIK3R1,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,25284480 +OncoKB,PIK3R1,Oncogenic,NA,LOF,NA,NA,NA,NA,20713702 +OncoKB,PIK3R2,Likely Neutral,NA,COF,NA,NA,NA,NA,21984976 +OncoKB,PIK3R2,Oncogenic,NA,GOF,NA,NA,NA,NA,21984976 +OncoKB,PIK3R2,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,21984976 +OncoKB,PIK3R2,Oncogenic,NA,GOF,NA,NA,NA,NA,21984976 +OncoKB,PIK3R2,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,"26520804, 22729224" +OncoKB,PIK3R2,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,25502460 +OncoKB,PIK3R2,Likely Neutral,NA,COF,NA,NA,NA,NA,21984976 +OncoKB,PIK3R2,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"26860062, 26520804" +OncoKB,PIK3R2,Likely Neutral,NA,COF,NA,NA,NA,NA,21984976 +OncoKB,ARID5B,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA, +OncoKB,HRAS,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,26888048 +OncoKB,HRAS,Oncogenic,NA,GOF,NA,NA,NA,NA,"17054105, 19075190, 20570890, 20147967, 2403644" +OncoKB,HRAS,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"9219684, 21993244, 22589270, 18713003" +OncoKB,HRAS,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,20570890 +OncoKB,HRAS,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"26561417, 9219684, 26037647, 21993244, 22722830, 20147967" +OncoKB,HRAS,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,25600866 +OncoKB,HRAS,Oncogenic,NA,GOF,NA,NA,NA,NA,"10574788, 18073111, 9219684, 21993244, 20194776" +OncoKB,HRAS,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,"17084704, 20838576" +OncoKB,HRAS,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,17412879 +OncoKB,HRAS,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"9219684, 21993244, 25013473" +OncoKB,HRAS,Oncogenic,NA,GOF,NA,NA,NA,NA,"9219684, 21993244, 24123531" +OncoKB,HRAS,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,1730690 +OncoKB,HRAS,Oncogenic,NA,GOF,NA,NA,NA,NA,"9219684, 21993244, 20979192, 25284075, 24129065" +OncoKB,HRAS,Oncogenic,NA,GOF,NA,NA,NA,NA,"9219684, 21993244, 24240680, 22589270" +OncoKB,HRAS,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"10574788, 25705018, 9219684, 21993244, 20194776, 20147967" +OncoKB,HRAS,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"10574788, 9219684, 21993244, 20194776, 25437878" +OncoKB,HRAS,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,18247425 +OncoKB,HRAS,Oncogenic,NA,GOF,NA,NA,NA,NA,"22256804, 10574788, 9219684, 21993244, 20194776" +OncoKB,HRAS,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"8221670, 3283542, 1855225" +OncoKB,HRAS,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"9219684, 21993244" +OncoKB,HRAS,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"25705018, 9219684, 21993244, 24256730, 16051643, 26841430" +OncoKB,HRAS,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"16474404, 8246952" +OncoKB,HRAS,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,24516166 +OncoKB,HRAS,Oncogenic,NA,GOF,NA,NA,NA,NA,"17054105, 16443854, 20570890, 24247240, 20147967" +OncoKB,HRAS,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"25705018, 9219684, 21993244, 17211612, 21079152" +OncoKB,MLH1,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,18206535 +OncoKB,MLH1,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"24362816, 16216036, 15713769" +OncoKB,MLH1,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,"23435383, 24362816" +OncoKB,MLH1,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,21120944 +OncoKB,MLH1,Likely Neutral,NA,COF,NA,NA,NA,NA,"24362816, 21120944" +OncoKB,MLH1,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,"23435383, 24362816" +OncoKB,MLH1,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"23435383, 24362816" +OncoKB,MLH1,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,"23435383, 24362816" +OncoKB,MLH1,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,"23435383, 24362816" +OncoKB,MLH1,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,"24362816, 8566964, 12919140, 11781295" +OncoKB,MLH1,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,23435383 +OncoKB,MLH1,Likely Neutral,NA,COF,NA,NA,NA,NA,"24362816, 19863800" +OncoKB,MLH1,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"22426235, 24362816, 18205192" +OncoKB,MLH1,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,23435383 +OncoKB,MLH1,Likely Neutral,NA,COF,NA,NA,NA,NA,"12037578, 24362816" +OncoKB,MLH1,Likely Neutral,NA,COF,NA,NA,NA,NA,"24362816, 25092538" +OncoKB,MLH1,Oncogenic,NA,LOF,NA,NA,NA,NA,24755471 +OncoKB,MLH1,Oncogenic,NA,LOF,NA,NA,NA,NA,23435383 +OncoKB,MLH1,Likely Neutral,NA,COF,NA,NA,NA,NA,"24362816, 11781295" +OncoKB,MLH1,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,"23435383, 24362816" +OncoKB,MLH1,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,"23435383, 24362816" +OncoKB,MLH1,Oncogenic,NA,LOF,NA,NA,NA,NA,"19419416, 18205192, 11781295" +OncoKB,MLH1,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"23435383, 24362816" +OncoKB,MLH1,Likely Neutral,NA,COF,NA,NA,NA,NA,"12810663, 17510385, 11781295" +OncoKB,MLH1,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,20020535 +OncoKB,MLH1,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,"16528606, 24362816, 17510385, 9927034" +OncoKB,MLH1,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,"23435383, 24362816" +OncoKB,MLH1,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,"24755471, 20668451" +OncoKB,MLH1,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,23435383 +OncoKB,MLH1,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"12697830, 7892206, 11781295" +OncoKB,MLH1,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,"24362816, 22736432" +OncoKB,MLH1,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"20020535, 17210669, 24362816" +OncoKB,MLH1,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,"23435383, 24362816" +OncoKB,MLH1,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,"24362816, 23403630" +OncoKB,MLH1,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"22290698, 24362816, 24278394" +OncoKB,MLH1,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,"23435383, 24362816" +OncoKB,MLH1,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,"15872200, 14512394" +OncoKB,MLH1,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"11343035, 24362816, 9927033" +OncoKB,MLH1,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"23435383, 24362816" +OncoKB,FGF3,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,"24265351, 22890726, 10845805, 9205106" +OncoKB,FGF4,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,"24265351, 22890726" +OncoKB,KMT2A,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,25998713 +OncoKB,KMT2A,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"25998713, 23628958, 8681380, 11265751, 18455126" +OncoKB,KMT2A,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,"17908926, 15378024" +OncoKB,AKT1,Oncogenic,NA,GOF,NA,NA,NA,NA,23134728 +OncoKB,AKT1,Likely Neutral,NA,COF,NA,NA,NA,NA,"23134728, 23237847, 19706770" +OncoKB,AKT1,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,"14655756, 12631397, 1409633, 24896186, 17616691, 3037531, 11485901" +OncoKB,AKT1,Oncogenic,NA,GOF,NA,NA,NA,NA,23134728 +OncoKB,AKT1,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,"25856301, 18669636, 25551293" +OncoKB,AKT1,Likely Oncogenic,NA,Likely SOF,NA,NA,NA,NA,"25551293, 22460905" +OncoKB,AKT1,Oncogenic,NA,GOF,NA,NA,NA,NA,23134728 +OncoKB,AKT1,Oncogenic,NA,GOF,NA,NA,NA,NA,"23134728, 20440266, 23741320, 18256540, 21793738, 17611497, 9843996" +OncoKB,AKT1,Likely Neutral,NA,COF,NA,NA,NA,NA,"23134728, 23237847, 19706770" +OncoKB,AKT1,Likely Neutral,NA,COF,NA,NA,NA,NA,23134728 +OncoKB,AKT1,Oncogenic,NA,GOF,NA,NA,NA,NA,23134728 +OncoKB,AKT1,Oncogenic,NA,GOF,NA,NA,NA,NA,23134728 +OncoKB,AKT1,Oncogenic,NA,GOF,NA,NA,NA,NA,"23134728, 27147599, 20886116" +OncoKB,AKT1,Oncogenic,NA,GOF,NA,NA,NA,NA,23134728 +OncoKB,AKT1,Oncogenic,NA,GOF,NA,NA,NA,NA,23134728 +OncoKB,AKT1,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,27147599 +OncoKB,AKT1,Oncogenic,NA,GOF,NA,NA,NA,NA,23134728 +OncoKB,AKT1,Likely Neutral,NA,COF,NA,NA,NA,NA,23134728 +OncoKB,AKT1,Oncogenic,NA,GOF,NA,NA,NA,NA,23134728 +OncoKB,AKT1,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,"23134728, 20886116, 24265152" +OncoKB,AKT1,Likely Oncogenic,NA,Likely SOF,NA,NA,NA,NA,"7774014, 25551293" +OncoKB,AKT1,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"22722193, 23237847" +OncoKB,AKT1,Oncogenic,NA,GOF,NA,NA,NA,NA,23134728 +OncoKB,AKT1,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,27147599 +OncoKB,AKT1,Oncogenic,NA,GOF,NA,NA,NA,NA,23134728 +OncoKB,AKT1,Oncogenic,NA,GOF,NA,NA,NA,NA,19802009 +OncoKB,AKT1,Likely Neutral,NA,COF,NA,NA,NA,NA,"23134728, 23237847, 19706770" +OncoKB,AKT1,Likely Neutral,NA,COF,NA,NA,NA,NA,23134728 +OncoKB,AKT1,Oncogenic,NA,GOF,NA,NA,NA,NA,23134728 +OncoKB,AKT1,Likely Neutral,NA,COF,NA,NA,NA,NA,23134728 +OncoKB,AKT1,Oncogenic,NA,GOF,NA,NA,NA,NA,"9690513, 9843996" +OncoKB,AKT1,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,"23134728, 20886116" +OncoKB,AKT2,Likely Oncogenic,NA,SOF,NA,NA,NA,NA,25551293 +OncoKB,AKT2,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,19738612 +OncoKB,AKT2,Oncogenic,NA,GOF,NA,NA,NA,NA,8622988 +OncoKB,AKT2,Oncogenic,NA,GOF,NA,NA,NA,NA,"19372382, 24285683, 21979934, 17611497" +OncoKB,AKT2,Oncogenic,NA,GOF,NA,NA,NA,NA,25551293 +OncoKB,AKT2,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,"19738612, 25551293" +OncoKB,AKT2,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,19738612 +OncoKB,AKT2,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,25733895 +OncoKB,AKT2,Likely Oncogenic,NA,SOF,NA,NA,NA,NA,25551293 +OncoKB,AKT2,Oncogenic,NA,GOF,NA,NA,NA,NA,25551293 +OncoKB,AKT2,Oncogenic,NA,GOF,NA,NA,NA,NA,25551293 +OncoKB,AKT2,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,25733895 +OncoKB,FGFR1,Likely Neutral,NA,Likely LOF,NA,NA,NA,NA,19733072 +OncoKB,FGFR1,Oncogenic,NA,GOF,NA,NA,NA,NA,"22837387, 23558953" +OncoKB,FGFR1,Oncogenic,NA,GOF,NA,NA,NA,NA,"24777483, 24806303, 19224897, 24705251, 22820256, 16186508, 23817572, 24140581, 14602678" +OncoKB,FGFR1,Oncogenic,NA,GOF,NA,NA,NA,NA,"24265351, 23658459, 22960745, 26451490, 15863030, 15863033, 21160078, 24476821, 25677745, 17121884" +OncoKB,FGFR1,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,23558953 +OncoKB,FGFR1,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,"11739186, 20226962" +OncoKB,FGFR1,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,"20226962, 10887137, 10935490" +OncoKB,FGFR1,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,"15509736, 23817572" +OncoKB,FGFR1,Likely Neutral,NA,COF,NA,NA,NA,NA,26826182 +OncoKB,FGFR1,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,23558953 +OncoKB,FGFR1,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,"11689702, 16690081, 21330321, 20226962" +OncoKB,FGFR1,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"15157880, 25686244" +OncoKB,FGFR1,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,"10688839, 20226962" +OncoKB,FGFR1,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,21330321 +OncoKB,FGFR3,Oncogenic,NA,GOF,NA,NA,NA,NA,23175443 +OncoKB,FGFR3,Likely Neutral,NA,COF,NA,NA,NA,NA,26992226 +OncoKB,FGFR3,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"11055896, 19749790" +OncoKB,FGFR3,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,26992226 +OncoKB,FGFR3,Likely Neutral,NA,COF,NA,NA,NA,NA,26992226 +OncoKB,FGFR3,Oncogenic,NA,GOF,NA,NA,NA,NA,"25609060, 22837387" +OncoKB,FGFR3,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,"12461689, 10646125, 10611230, 21324899" +OncoKB,FGFR3,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,26992226 +OncoKB,FGFR3,Likely Neutral,NA,COF,NA,NA,NA,NA,26992226 +OncoKB,FGFR3,Likely Neutral,NA,COF,NA,NA,NA,NA,26992226 +OncoKB,FGFR3,Likely Neutral,NA,COF,NA,NA,NA,NA,26992226 +OncoKB,FGFR3,Likely Neutral,NA,COF,NA,NA,NA,NA,11157491 +OncoKB,FGFR3,Likely Neutral,NA,COF,NA,NA,NA,NA,26992226 +OncoKB,FGFR3,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,"19749790, 11429702" +OncoKB,FGFR3,Likely Neutral,NA,COF,NA,NA,NA,NA,26992226 +OncoKB,FGFR3,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,26992226 +OncoKB,FGFR3,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,23437153 +OncoKB,FGFR3,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,26992226 +OncoKB,FGFR3,Likely Neutral,NA,COF,NA,NA,NA,NA,26992226 +OncoKB,FGFR3,Oncogenic,NA,GOF,NA,NA,NA,NA,"19749790, 16338952, 11429702" +OncoKB,FGFR3,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"11055896, 19749790" +OncoKB,FGFR3,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"23298836, 23661334, 23558953" +OncoKB,FGFR3,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,12009017 +OncoKB,FGFR3,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,26992226 +OncoKB,FGFR3,Oncogenic,NA,GOF,NA,NA,NA,NA,26992226 +OncoKB,FGFR3,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"11055896, 19749790, 10053006" +OncoKB,FGFR3,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,12009017 +OncoKB,FGFR3,Likely Neutral,NA,COF,NA,NA,NA,NA,26992226 +OncoKB,FGFR3,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,22529939 +OncoKB,FGFR3,Oncogenic,NA,GOF,NA,NA,NA,NA,"19749790, 16338952, 17384684" +OncoKB,FGFR3,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"11055896, 19749790" +OncoKB,FGFR3,Oncogenic,NA,GOF,NA,NA,NA,NA,"17344846, 20094046, 19821490" +OncoKB,FGFR3,Likely Neutral,NA,COF,NA,NA,NA,NA,26992226 +OncoKB,FGFR3,Oncogenic,NA,GOF,NA,NA,NA,NA,17107900 +OncoKB,FGFR3,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"11055896, 19749790" +OncoKB,FGFR3,Oncogenic,NA,GOF,NA,NA,NA,NA,"22203368, 8640234" +OncoKB,FGFR3,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,22837387 +OncoKB,FGFR3,Likely Neutral,NA,Likely LOF,NA,NA,NA,NA,26992226 +OncoKB,FGFR3,Likely Neutral,NA,COF,NA,NA,NA,NA,26992226 +OncoKB,FGFR3,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,26992226 +OncoKB,FGFR3,Likely Neutral,NA,Likely LOF,NA,NA,NA,NA,26992226 +OncoKB,FGFR3,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,26992226 +OncoKB,FGFR3,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,11429702 +OncoKB,SPOP,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,"19818708, 18218622, 25766326" +OncoKB,SPOP,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,"19818708, 18218622, 25766326" +OncoKB,SPOP,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,"19818708, 18218622, 25766326" +OncoKB,SPOP,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"19818708, 18218622" +OncoKB,SPOP,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,"19818708, 18218622, 25274033, 24508459, 23559371" +OncoKB,SPOP,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,"19818708, 18218622, 25766326" +OncoKB,SPOP,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"19818708, 23559371, 24796539" +OncoKB,SPOP,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"19818708, 18218622, 22085717" +OncoKB,SPOP,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,"19818708, 18218622, 25274033, 24508459, 23559371" +OncoKB,SPOP,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,"19818708, 18218622, 25274033, 24508459, 23559371" +OncoKB,SPOP,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,"19818708, 18218622, 25766326" +OncoKB,SPOP,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,"19818708, 18218622, 25766326" +OncoKB,SPOP,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,"19818708, 18218622, 25766326" +OncoKB,SPOP,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,"19818708, 18218622, 25274033, 24508459, 23559371" +OncoKB,SPOP,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,"19818708, 18218622, 25766326" +OncoKB,SPOP,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,"19818708, 18218622, 25274033, 24508459, 23559371" +OncoKB,SPOP,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,"19818708, 18218622, 25766326" +OncoKB,SPOP,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"19818708, 18218622, 24990631" +OncoKB,SPOP,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,26344095 +OncoKB,SPOP,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,"19818708, 18218622, 25274033, 24508459, 23559371" +OncoKB,SPOP,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"19818708, 18218622, 24990631" +OncoKB,SPOP,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,"19818708, 18218622, 25274033, 24508459, 23559371" +OncoKB,SPOP,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,"19818708, 18218622, 25274033, 24508459, 23559371" +OncoKB,FGFR2,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,"22585574, 22558232" +OncoKB,FGFR2,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"20004243, 16844695" +OncoKB,FGFR2,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,19147536 +OncoKB,FGFR2,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,17803937 +OncoKB,FGFR2,Oncogenic,NA,GOF,NA,NA,NA,NA,"24122810, 23558953" +OncoKB,FGFR2,Oncogenic,NA,GOF,NA,NA,NA,NA,23908597 +OncoKB,FGFR2,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,24550739 +OncoKB,FGFR2,Oncogenic,NA,GOF,NA,NA,NA,NA,"20094046, 20101236" +OncoKB,FGFR2,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,19147536 +OncoKB,FGFR2,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,19147536 +OncoKB,FGFR2,Oncogenic,NA,GOF,NA,NA,NA,NA,26048680 +OncoKB,FGFR2,Oncogenic,NA,GOF,NA,NA,NA,NA,26048680 +OncoKB,FGFR2,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,"23527311, 15908952" +OncoKB,FGFR2,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,9539778 +OncoKB,FGFR2,Oncogenic,NA,GOF,NA,NA,NA,NA,24563622 +OncoKB,FGFR2,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,17803937 +OncoKB,FGFR2,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,23908597 +OncoKB,FGFR2,Oncogenic,NA,GOF,NA,NA,NA,NA,26048680 +OncoKB,FGFR2,Oncogenic,NA,GOF,NA,NA,NA,NA,24122810 +OncoKB,FGFR2,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,21928350 +OncoKB,FGFR2,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,23913723 +OncoKB,FGFR2,Oncogenic,NA,GOF,NA,NA,NA,NA,23908597 +OncoKB,FGFR2,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,"17803937, 23527311, 17525745" +OncoKB,FGFR2,Likely Neutral,NA,COF,NA,NA,NA,NA,26048680 +OncoKB,FGFR2,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,19147536 +OncoKB,FGFR2,Likely Neutral,NA,Likely LOF,NA,NA,NA,NA,19147536 +OncoKB,FGFR2,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,19147536 +OncoKB,FGFR2,Oncogenic,NA,GOF,NA,NA,NA,NA,"23908597, 17525745, 18552176" +OncoKB,FGFR2,Likely Neutral,NA,COF,NA,NA,NA,NA,18552176 +OncoKB,FGFR2,Oncogenic,NA,GOF,NA,NA,NA,NA,23908597 +OncoKB,FGFR2,Oncogenic,NA,GOF,NA,NA,NA,NA,23908597 +OncoKB,FGFR2,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,19147536 +OncoKB,FGFR2,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,19147536 +OncoKB,FGFR2,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,17525745 +OncoKB,FGFR2,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,18552176 +OncoKB,FGFR2,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"17803937, 16061565" +OncoKB,FGFR2,Oncogenic,NA,GOF,NA,NA,NA,NA,"9136983, 17525745" +OncoKB,FGFR2,Oncogenic,NA,GOF,NA,NA,NA,NA,"24265351, 11121055" +OncoKB,FGFR2,Oncogenic,NA,GOF,NA,NA,NA,NA,23908597 +OncoKB,FGFR2,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,23558953 +OncoKB,FGFR2,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"25608663, 26258846, 23558953" +OncoKB,FGFR2,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,23908597 +OncoKB,FGFR2,Oncogenic,NA,GOF,NA,NA,NA,NA,"17525745, 18552176" +OncoKB,FGFR2,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,24908667 +OncoKB,FGFR2,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,23558953 +OncoKB,FGFR2,Likely Neutral,NA,COF,NA,NA,NA,NA,18552176 +OncoKB,FGFR2,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,19147536 +OncoKB,FGFR2,Likely Neutral,NA,COF,NA,NA,NA,NA,26048680 +OncoKB,FGFR2,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,23558953 +OncoKB,FGFR2,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,19147536 +OncoKB,FGFR2,Likely Neutral,NA,COF,NA,NA,NA,NA,19147536 +OncoKB,FGFR2,Oncogenic,NA,GOF,NA,NA,NA,NA,25608663 +OncoKB,FGFR2,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,19147536 +OncoKB,FGFR2,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,"17803937, 23527311" +OncoKB,FGFR2,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,19147536 +OncoKB,FGFR4,Oncogenic,NA,GOF,NA,NA,NA,NA,19946327 +OncoKB,FGFR4,Oncogenic,NA,GOF,NA,NA,NA,NA,"15863030, 25053532, 20094046, 23344261" +OncoKB,FGFR4,Oncogenic,NA,GOF,NA,NA,NA,NA,"19809159, 25219510" +OncoKB,FGFR4,Oncogenic,NA,GOF,NA,NA,NA,NA,19809159 +OncoKB,KDM6A,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"19330029, 25225064, 27028180, 22197486" +OncoKB,KDM6A,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"19330029, 24633898, 25225064" +OncoKB,ALK,Likely Neutral,NA,COF,NA,NA,NA,NA,"21383740, 25517749" +OncoKB,ALK,Oncogenic,NA,GOF,NA,NA,NA,NA,"22277784, 21383740, 26144315, 26698910, 24736079, 24675041" +OncoKB,ALK,Oncogenic,NA,GOF,NA,NA,NA,NA,"21030459, 20979472" +OncoKB,ALK,Oncogenic,NA,GOF,NA,NA,NA,NA,"22277784, 21383740, 22034911, 24675041" +OncoKB,ALK,Oncogenic,NA,GOF,NA,NA,NA,NA,"21948233, 21383740" +OncoKB,ALK,Oncogenic,NA,GOF,NA,NA,NA,NA,"21383740, 25421750" +OncoKB,ALK,Oncogenic,NA,GOF,NA,NA,NA,NA,"21383740, 25517749, 27049722, 24491302, 25749034" +OncoKB,ALK,Likely Neutral,NA,COF,NA,NA,NA,NA,"21383740, 25517749" +OncoKB,ALK,Oncogenic,NA,GOF,NA,NA,NA,NA,"22277784, 21383740, 26144315, 24675041" +OncoKB,ALK,Oncogenic,NA,GOF,NA,NA,NA,NA,"21383740, 25749034" +OncoKB,ALK,Oncogenic,NA,GOF,NA,NA,NA,NA,"21383740, 25421750" +OncoKB,ALK,Oncogenic,NA,GOF,NA,NA,NA,NA,21030459 +OncoKB,ALK,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"21383740, 18923525, 23104988, 26786851, 18724359" +OncoKB,ALK,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,21847362 +OncoKB,ALK,Oncogenic,NA,GOF,NA,NA,NA,NA,"27009859, 21383740, 25517749, 27049722" +OncoKB,ALK,Oncogenic,NA,GOF,NA,NA,NA,NA,"22235099, 27009859, 26849637, 23401436, 21948233, 22277784, 21383740, 27049722, 26144315, 26698910, 24675041" +OncoKB,ALK,Likely Neutral,NA,COF,NA,NA,NA,NA,"21383740, 23104988" +OncoKB,ALK,Oncogenic,NA,GOF,NA,NA,NA,NA,"21383740, 25421750" +OncoKB,ALK,Likely Neutral,NA,COF,NA,NA,NA,NA,"21383740, 23104988" +OncoKB,ALK,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,"21847362, 12855999" +OncoKB,ALK,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,23598171 +OncoKB,ALK,Oncogenic,NA,GOF,NA,NA,NA,NA,25749034 +OncoKB,ALK,Oncogenic,NA,GOF,NA,NA,NA,NA,"21383740, 23104988" +OncoKB,ALK,Oncogenic,NA,GOF,NA,NA,NA,NA,"21383740, 21596819" +OncoKB,ALK,Oncogenic,NA,GOF,NA,NA,NA,NA,"18923523, 21383740, 18923525, 25517749, 26829053, 27049722, 26554404, 22072639" +OncoKB,ALK,Likely Neutral,NA,COF,NA,NA,NA,NA,"21383740, 25517749" +OncoKB,ALK,Oncogenic,NA,GOF,NA,NA,NA,NA,"21791641, 21383740, 26144315" +OncoKB,ALK,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,24613930 +OncoKB,ALK,Oncogenic,NA,GOF,NA,NA,NA,NA,"21383740, 25517749, 27049722" +OncoKB,ALK,Oncogenic,NA,GOF,NA,NA,NA,NA,"22235099, 23434628, 22277784, 21383740, 25517749, 26144315, 20979473, 26698910, 22034911, 25421750, 21613408, 24675041" +OncoKB,ALK,Oncogenic,NA,GOF,NA,NA,NA,NA,"26133723, 18923525, 26144315, 12424201, 25421750, 12879008, 21613408" +OncoKB,ALK,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,21847362 +OncoKB,ALK,Oncogenic,NA,GOF,NA,NA,NA,NA,"21383740, 25517749" +OncoKB,ALK,Oncogenic,NA,GOF,NA,NA,NA,NA,"21383740, 25749034" +OncoKB,ALK,Oncogenic,NA,GOF,NA,NA,NA,NA,"22235099, 21383740, 26144315, 20979473, 26698910, 25749034, 21613408, 24675041" +OncoKB,ALK,Oncogenic,NA,GOF,NA,NA,NA,NA,"21383740, 25421750" +OncoKB,ALK,Oncogenic,NA,GOF,NA,NA,NA,NA,"21948233, 21383740" +OncoKB,ALK,Oncogenic,NA,GOF,NA,NA,NA,NA,"21383740, 25517749" +OncoKB,ALK,Likely Neutral,NA,COF,NA,NA,NA,NA,"21383740, 25517749" +OncoKB,ALK,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,21847362 +OncoKB,ALK,Likely Neutral,NA,COF,NA,NA,NA,NA,"21383740, 23104988" +OncoKB,ALK,Oncogenic,NA,GOF,NA,NA,NA,NA,"21383740, 24491302" +OncoKB,ALK,Oncogenic,NA,GOF,NA,NA,NA,NA,"18923523, 21383740, 27049722, 25421750" +OncoKB,ALK,Oncogenic,NA,GOF,NA,NA,NA,NA,"25228534, 21383740, 22034911, 25749034, 24675041, 25736571" +OncoKB,ALK,Likely Neutral,NA,COF,NA,NA,NA,NA,"21383740, 25517749" +OncoKB,ALK,Oncogenic,NA,GOF,NA,NA,NA,NA,"21383740, 25517749" +OncoKB,ALK,Oncogenic,NA,GOF,NA,NA,NA,NA,"21383740, 21596819, 18923524" +OncoKB,ALK,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"21948233, 25421750, 25749034" +OncoKB,ALK,Oncogenic,NA,GOF,NA,NA,NA,NA,"21383740, 22034911" +OncoKB,ALK,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"25071110, 21383740" +OncoKB,ALK,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,"26144315, 21613408" +OncoKB,ALK,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,24060861 +OncoKB,ALK,Oncogenic,NA,GOF,NA,NA,NA,NA,"21383740, 23104988" +OncoKB,ALK,Likely Neutral,NA,COF,NA,NA,NA,NA,"21383740, 25517749" +OncoKB,ALK,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"21474455, 24356251, 22614325" +OncoKB,ALK,Oncogenic,NA,GOF,NA,NA,NA,NA,"21383740, 25517749, 27049722, 26554404, 22034911, 23598171" +OncoKB,ALK,Likely Neutral,NA,COF,NA,NA,NA,NA,"21383740, 23104988" +OncoKB,ALK,Oncogenic,NA,GOF,NA,NA,NA,NA,"21383740, 21596819, 26698910, 25421750" +OncoKB,ALK,Oncogenic,NA,GOF,NA,NA,NA,NA,"25071110, 21383740, 25517749, 27049722, 23598171" +OncoKB,ALK,Oncogenic,NA,GOF,NA,NA,NA,NA,"21383740, 25517749, 22072639, 18724359, 21030459, 18923523, 27009859, 21948233, 21596819, 20719933, 18923525, 27049722, 26144315, 26554404, 23104988, 18923524, 26786851, 21242967, 21613408" +OncoKB,ALK,Likely Neutral,NA,COF,NA,NA,NA,NA,"21383740, 23104988" +OncoKB,ALK,Oncogenic,NA,GOF,NA,NA,NA,NA,"21030459, 22235099, 25228534, 21791641, 21948233, 22277784, 18923524, 21613408, 24675041" +OncoKB,ALK,Oncogenic,NA,GOF,NA,NA,NA,NA,"25228534, 21383740" +OncoKB,ALK,Oncogenic,NA,GOF,NA,NA,NA,NA,"21383740, 25517749, 23104988" +OncoKB,ALK,Oncogenic,NA,GOF,NA,NA,NA,NA,"21948233, 21383740" +OncoKB,ALK,Oncogenic,NA,GOF,NA,NA,NA,NA,"21383740, 24675041" +OncoKB,ALK,Likely Neutral,NA,COF,NA,NA,NA,NA,"27009859, 21383740, 18923525, 25517749, 23104988" +OncoKB,ALK,Oncogenic,NA,GOF,NA,NA,NA,NA,"22277784, 21383740, 26144315, 24675041" +OncoKB,ALK,Likely Neutral,NA,COF,NA,NA,NA,NA,"21383740, 23104988" +OncoKB,ALK,Likely Neutral,NA,COF,NA,NA,NA,NA,"21383740, 23104988" +OncoKB,ALK,Oncogenic,NA,GOF,NA,NA,NA,NA,"27009859, 21383740, 26464158" +OncoKB,ALK,Oncogenic,NA,GOF,NA,NA,NA,NA,"21383740, 22034911" +OncoKB,ALK,Oncogenic,NA,GOF,NA,NA,NA,NA,"21383740, 23104988, 25749034" +OncoKB,ALK,Oncogenic,NA,GOF,NA,NA,NA,NA,23239810 +OncoKB,ALK,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,26633560 +OncoKB,ALK,Oncogenic,NA,GOF,NA,NA,NA,NA,"21383740, 26698910, 22034911, 24675041" +OncoKB,ALK,Likely Neutral,NA,COF,NA,NA,NA,NA,"21383740, 23104988" +OncoKB,SDHB,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,"17639058, 15987702" +OncoKB,RAD54L,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,"15056673, 10362365" +OncoKB,SDHC,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,24423348 +OncoKB,VEGFA,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,"24687604, 21743435, 24114200, 21495021" +OncoKB,MPL,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"14764528, 8695859" +OncoKB,MPL,Oncogenic,NA,GOF,NA,NA,NA,NA,16834459 +OncoKB,MPL,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"16868251, 17709604" +OncoKB,MPL,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"25538044, 23351976" +OncoKB,PMS1,Oncogenic,NA,LOF,NA,NA,NA,NA,8072530 +OncoKB,CARM1,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,19843527 +OncoKB,CARM1,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,19843527 +OncoKB,CARM1,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,19843527 +OncoKB,CARM1,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,19843527 +OncoKB,FOXO1,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"17646672, 16670091" +OncoKB,VHL,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,24969085 +OncoKB,VHL,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,"10535940, 10973499, 19602254" +OncoKB,VHL,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,10823831 +OncoKB,VHL,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,22071692 +OncoKB,VHL,Oncogenic,NA,LOF,NA,NA,NA,NA,"10535940, 24755468, 19030229" +OncoKB,VHL,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,19602254 +OncoKB,VHL,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,15611064 +OncoKB,VHL,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"10823831, 10535940" +OncoKB,VHL,Likely Neutral,NA,COF,NA,NA,NA,NA,16884327 +OncoKB,VHL,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,10823831 +OncoKB,VHL,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,10823831 +OncoKB,VHL,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"21386872, 12050673, 12004076, 22825683" +OncoKB,VHL,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,14636579 +OncoKB,VHL,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,"18544564, 15611064" +OncoKB,VHL,Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"21386872, 23632291, 25093046, 19764026" +OncoKB,VHL,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,19602254 +OncoKB,VHL,Likely Neutral,NA,COF,NA,NA,NA,NA,11865071 +OncoKB,VHL,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,"10823831, 10535940" +OncoKB,VHL,Oncogenic,NA,LOF,NA,NA,NA,NA,"25563310, 14973063, 23824745, 12202531" +OncoKB,VHL,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,26503325 +OncoKB,VHL,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,14636579 +OncoKB,VHL,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,14636579 +OncoKB,VHL,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,"10823831, 15611064" +OncoKB,VHL,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"14636579, 27179072" +OncoKB,VHL,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,14636579 +OncoKB,VHL,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,14636579 +OncoKB,VHL,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,10823831 +OncoKB,VHL,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,15611064 +OncoKB,VHL,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"26619011, 15611064" +OncoKB,VHL,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,26503325 +OncoKB,VHL,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,10823831 +OncoKB,VHL,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,14636579 +OncoKB,VHL,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,10823831 +OncoKB,VHL,Likely Neutral,NA,LOF,NA,NA,NA,NA,15611064 +OncoKB,VHL,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,19602254 +OncoKB,VHL,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"26619011, 11865071" +OncoKB,VHL,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,2706960 +OncoKB,VHL,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,15611064 +OncoKB,VHL,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,15611064 +OncoKB,VHL,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"14636579, 27179072" +OncoKB,VHL,Oncogenic,NA,LOF,NA,NA,NA,NA,21685897 +OncoKB,VHL,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,15611064 +OncoKB,VHL,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"24969085, 12202531" +OncoKB,VHL,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,10823831 +OncoKB,VHL,Oncogenic,NA,LOF,NA,NA,NA,NA,21685897 +OncoKB,MAP2K4,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,21896780 +OncoKB,MAP2K4,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"21896780, 26619011" +OncoKB,MAP2K4,Oncogenic,NA,LOF,NA,NA,NA,NA,"20668451, 15122334" +OncoKB,MAP2K4,Oncogenic,NA,LOF,NA,NA,NA,NA,"20668451, 15122334" +OncoKB,MAP2K4,Oncogenic,NA,LOF,NA,NA,NA,NA,"20668451, 15122334" +OncoKB,MAP2K4,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,21896780 +OncoKB,MAP2K4,Oncogenic,NA,LOF,NA,NA,NA,NA,"20668451, 15122334" +OncoKB,MAP2K4,Oncogenic,NA,LOF,NA,NA,NA,NA,"21896780, 20668451, 15122334" +OncoKB,MAP2K4,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,21896780 +OncoKB,MAP2K4,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,21896780 +OncoKB,MAP2K4,Oncogenic,NA,LOF,NA,NA,NA,NA,"20668451, 15122334" +OncoKB,RRAS2,Oncogenic,NA,GOF,NA,NA,NA,NA,8052619 +OncoKB,FLT1,Inconclusive,NA,Inconclusive,NA,NA,NA,NA, +OncoKB,FLT3,Oncogenic,NA,GOF,NA,NA,NA,NA,"11290608, 23631653, 15256420, 26108694, 24255108" +OncoKB,FLT3,Oncogenic,NA,GOF,NA,NA,NA,NA,18068628 +OncoKB,FLT3,Oncogenic,NA,GOF,NA,NA,NA,NA,"11290608, 15256420, 26108694" +OncoKB,FLT3,Oncogenic,NA,GOF,NA,NA,NA,NA,"9737679, 11090077, 23631653" +OncoKB,FLT3,Oncogenic,NA,GOF,NA,NA,NA,NA,"9737679, 11090077, 23631653" +OncoKB,FLT3,Oncogenic,NA,GOF,NA,NA,NA,NA,"9737679, 11090077, 23631653, 11756186" +OncoKB,FLT3,Oncogenic,NA,GOF,NA,NA,NA,NA,16410449 +OncoKB,FLT3,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,25847190 +OncoKB,FLT3,Oncogenic,NA,GOF,NA,NA,NA,NA,24608088 +OncoKB,FLT3,Likely Neutral,NA,Likely LOF,NA,NA,NA,NA,16684964 +OncoKB,FLT3,Oncogenic,NA,GOF,NA,NA,NA,NA,"9737679, 11090077, 23631653" +OncoKB,FLT3,Oncogenic,NA,GOF,NA,NA,NA,NA,"9737679, 11090077, 23631653, 11756186" +OncoKB,FLT3,Oncogenic,NA,GOF,NA,NA,NA,NA,"11290608, 15256420, 26108694" +OncoKB,FLT3,Likely Neutral,NA,COF,NA,NA,NA,NA,18068628 +OncoKB,FLT3,Likely Neutral,NA,COF,NA,NA,NA,NA,18068628 +OncoKB,FLT3,Oncogenic,NA,GOF,NA,NA,NA,NA,"9737679, 11090077, 23631653" +OncoKB,FLT3,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,15374944 +OncoKB,FLT3,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,23878140 +OncoKB,FLT3,Oncogenic,NA,GOF,NA,NA,NA,NA,"11290608, 15256420, 26108694" +OncoKB,FLT3,Oncogenic,NA,GOF,NA,NA,NA,NA,"9737679, 11090077, 23631653" +OncoKB,FLT3,Oncogenic,NA,GOF,NA,NA,NA,NA,18068628 +OncoKB,FLT3,Oncogenic,NA,GOF,NA,NA,NA,NA,16410449 +OncoKB,FLT3,Oncogenic,NA,GOF,NA,NA,NA,NA,16410449 +OncoKB,FLT3,Oncogenic,NA,GOF,NA,NA,NA,NA,23878140 +OncoKB,FLT3,Oncogenic,NA,GOF,NA,NA,NA,NA,"9737679, 11090077, 23631653, 11756186" +OncoKB,FLT3,Likely Neutral,NA,COF,NA,NA,NA,NA,18068628 +OncoKB,FLT3,Oncogenic,NA,GOF,NA,NA,NA,NA,"9737679, 11090077, 23631653, 12384447" +OncoKB,FLT3,Oncogenic,NA,GOF,NA,NA,NA,NA,15256420 +OncoKB,FLT3,Likely Neutral,NA,COF,NA,NA,NA,NA,18068628 +OncoKB,FLT3,Likely Neutral,NA,LOF,NA,NA,NA,NA,27272783 +OncoKB,FLT3,Oncogenic,NA,GOF,NA,NA,NA,NA,15178581 +OncoKB,FLT3,Oncogenic,NA,GOF,NA,NA,NA,NA,18068628 +OncoKB,FLT3,Likely Neutral,NA,COF,NA,NA,NA,NA,18068628 +OncoKB,FLT3,Oncogenic,NA,GOF,NA,NA,NA,NA,"11290608, 15256420, 26108694" +OncoKB,FLT3,Oncogenic,NA,GOF,NA,NA,NA,NA,16410449 +OncoKB,FLT3,Oncogenic,NA,GOF,NA,NA,NA,NA,24608088 +OncoKB,FLT3,Oncogenic,NA,GOF,NA,NA,NA,NA,"9737679, 11090077, 23631653" +OncoKB,FLT3,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,25847190 +OncoKB,FLT3,Oncogenic,NA,GOF,NA,NA,NA,NA,16410449 +OncoKB,FLT3,Oncogenic,NA,GOF,NA,NA,NA,NA,"9737679, 11090077, 23631653" +OncoKB,FLT3,Oncogenic,NA,GOF,NA,NA,NA,NA,"9737679, 11090077, 23631653" +OncoKB,FLT3,Oncogenic,NA,GOF,NA,NA,NA,NA,"11290608, 15256420, 26108694" +OncoKB,FLT3,Oncogenic,NA,GOF,NA,NA,NA,NA,"9737679, 11090077, 23631653, 11756186" +OncoKB,FLT3,Oncogenic,NA,GOF,NA,NA,NA,NA,18068628 +OncoKB,FLT3,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,"25848357, 27906677" +OncoKB,FLT3,Oncogenic,NA,GOF,NA,NA,NA,NA,23631653 +OncoKB,FLT3,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,22875611 +OncoKB,FLT3,Oncogenic,NA,GOF,NA,NA,NA,NA,18068628 +OncoKB,FLT3,Oncogenic,NA,GOF,NA,NA,NA,NA,"19318574, 23430109" +OncoKB,FLT3,Oncogenic,NA,GOF,NA,NA,NA,NA,15345593 +OncoKB,FLT3,Likely Neutral,NA,COF,NA,NA,NA,NA,18068628 +OncoKB,FLT3,Likely Neutral,NA,COF,NA,NA,NA,NA,18068628 +OncoKB,FLT3,Oncogenic,NA,GOF,NA,NA,NA,NA,"9737679, 11090077, 23631653, 11756186" +OncoKB,FLT3,Oncogenic,NA,GOF,NA,NA,NA,NA,"9737679, 11090077, 23631653" +OncoKB,PMS2,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"19479271, 24027009" +OncoKB,PMS2,Likely Neutral,NA,COF,NA,NA,NA,NA,"15256438, 24362816, 24027009" +OncoKB,PMS2,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"12697830, 20487569, 23582141, 21376568, 7892206, 16144131, 9488480" +OncoKB,PMS2,Oncogenic,NA,LOF,NA,NA,NA,NA,25512458 +OncoKB,PMS2,Likely Neutral,NA,COF,NA,NA,NA,NA,"24362816, 24027009" +OncoKB,PMS2,Likely Neutral,NA,COF,NA,NA,NA,NA,"24362816, 24027009" +OncoKB,PMS2,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"24362816, 16507833" +OncoKB,PMS2,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,24362816 +OncoKB,PMS2,Oncogenic,NA,LOF,NA,NA,NA,NA,25691505 +OncoKB,PMS2,Likely Neutral,NA,COF,NA,NA,NA,NA,"24362816, 24027009" +OncoKB,PMS2,Oncogenic,NA,LOF,NA,NA,NA,NA,"20864418, 24027009" +OncoKB,PMS2,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,24362816 +OncoKB,PMS2,Oncogenic,NA,LOF,NA,NA,NA,NA,"18602922, 25883011, 23709753, 17557300, 24027009, 2257789, 18709565, 16144131" +OncoKB,PMS2,Likely Neutral,NA,COF,NA,NA,NA,NA,"24362816, 24027009" +OncoKB,PMS2,Oncogenic,NA,LOF,NA,NA,NA,NA,24027009 +OncoKB,PMS2,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"18602922, 23837913, 16472587" +OncoKB,PMS2,Likely Neutral,NA,COF,NA,NA,NA,NA,24362816 +OncoKB,PMS2,Likely Neutral,NA,COF,NA,NA,NA,NA,"24362816, 24027009" +OncoKB,SRSF2,Oncogenic,NA,LOF,NA,NA,NA,NA,"27135740, 25965569, 26124281, 26261309" +OncoKB,WHSC1,Oncogenic,NA,GOF,NA,NA,NA,NA,"23823660, 24076604" +OncoKB,PPM1D,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,"25742468, 24880341, 23907125" +OncoKB,POLD1,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA, +OncoKB,POLE,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,"23263490, 25228659" +OncoKB,POLE,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,25228659 +OncoKB,POLE,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,25228659 +OncoKB,POLE,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"25228659, 24472300" +OncoKB,POLE,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,"21157497, 25228659" +OncoKB,POLE,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,25228659 +OncoKB,POLE,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,25228659 +OncoKB,POLE,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,"25228659, 23636398" +OncoKB,POLE,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"25228659, 24472300" +OncoKB,POLE,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,25228659 +OncoKB,POLE,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,"25228659, 23636398" +OncoKB,KNSTRN,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,25194279 +OncoKB,KNSTRN,Oncogenic,NA,LOF,NA,NA,NA,NA,25194279 +OncoKB,KNSTRN,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,25194279 +OncoKB,KNSTRN,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,25194279 +OncoKB,KNSTRN,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,25194279 +OncoKB,PIK3R3,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"25424831, 27766312" +OncoKB,APC,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"11062151, 15561772, 11257105" +OncoKB,APC,Oncogenic,NA,LOF,NA,NA,NA,NA,19111562 +OncoKB,APC,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"8259511, 15643602, 25317407, 11867715" +OncoKB,APC,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,18166348 +OncoKB,APC,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,9724771 +OncoKB,APC,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,11606402 +OncoKB,RICTOR,Oncogenic,NA,GOF,NA,NA,NA,NA,"19934294, 20978191, 26370156, 19185849" +OncoKB,MSH2,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"9823339, 21970482, 22781090, 23264089, 17250661" +OncoKB,MSH2,Oncogenic,NA,LOF,NA,NA,NA,NA,24362816 +OncoKB,MSH2,Likely Neutral,NA,COF,NA,NA,NA,NA,24362816 +OncoKB,MSH2,Oncogenic,NA,LOF,NA,NA,NA,NA,"19459153, 26864202, 25430799" +OncoKB,MSH2,Oncogenic,NA,LOF,NA,NA,NA,NA,24362816 +OncoKB,MSH2,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"12595050, 10528862" +OncoKB,MSH2,Oncogenic,NA,LOF,NA,NA,NA,NA,24362816 +OncoKB,MSH2,Oncogenic,NA,LOF,NA,NA,NA,NA,24362816 +OncoKB,MSH2,Likely Neutral,NA,COF,NA,NA,NA,NA,24362816 +OncoKB,MSH2,Likely Neutral,NA,COF,NA,NA,NA,NA,"17101317, 21120944" +OncoKB,MSH2,Oncogenic,NA,LOF,NA,NA,NA,NA,"21120944, 18951462" +OncoKB,MSH2,Likely Neutral,NA,COF,NA,NA,NA,NA,"24362816, 22102614" +OncoKB,MSH2,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"24362816, 22102614, 26951660" +OncoKB,MSH2,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,"24362816, 10732761, 17720936" +OncoKB,MSH2,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"11257106, 23391514, 15528792, 10946232" +OncoKB,MSH2,Oncogenic,NA,LOF,NA,NA,NA,NA,7726159 +OncoKB,MSH2,Oncogenic,NA,LOF,NA,NA,NA,NA,24362816 +OncoKB,MSH2,Oncogenic,NA,LOF,NA,NA,NA,NA,8592341 +OncoKB,MSH2,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,24362816 +OncoKB,MSH2,Oncogenic,NA,LOF,NA,NA,NA,NA,8566964 +OncoKB,MSH2,Oncogenic,NA,LOF,NA,NA,NA,NA,24362816 +OncoKB,MSH2,Oncogenic,NA,LOF,NA,NA,NA,NA,24362816 +OncoKB,MSH2,Oncogenic,NA,LOF,NA,NA,NA,NA,24362816 +OncoKB,IDH1,Oncogenic,NA,SOF,NA,NA,NA,NA,"23264629, 23630074, 19935646" +OncoKB,IDH1,Likely Oncogenic,NA,SOF,NA,NA,NA,NA,21996744 +OncoKB,IDH1,Likely Neutral,NA,COF,NA,NA,NA,NA,27147599 +OncoKB,IDH1,Likely Neutral,NA,LOF,NA,NA,NA,NA,21996744 +OncoKB,IDH1,Likely Neutral,NA,COF,NA,NA,NA,NA,21996744 +OncoKB,IDH1,Likely Neutral,NA,LOF,NA,NA,NA,NA,21996744 +OncoKB,IDH1,Oncogenic,NA,SOF,NA,NA,NA,NA,"25730874, 23393090, 22763442, 22343901, 23630074, 22343889, 22899282, 19935646" +OncoKB,IDH1,Likely Neutral,NA,COF,NA,NA,NA,NA,21996744 +OncoKB,IDH1,Likely Neutral,NA,COF,NA,NA,NA,NA,27147599 +OncoKB,IDH1,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,21996744 +OncoKB,IDH1,Likely Oncogenic,NA,SOF,NA,NA,NA,NA,"21760534, 25257301, 23630074, 21912393, 22033490, 19935646" +OncoKB,IDH1,Likely Neutral,NA,LOF,NA,NA,NA,NA,21996744 +OncoKB,IDH1,Oncogenic,NA,SOF,NA,NA,NA,NA,"23630074, 23954893, 19935646" +OncoKB,IDH1,Likely Neutral,NA,COF,NA,NA,NA,NA,21996744 +OncoKB,IDH1,Likely Neutral,NA,LOF,NA,NA,NA,NA,20171178 +OncoKB,IDH1,Likely Oncogenic,NA,SOF,NA,NA,NA,NA,21996744 +OncoKB,IDH1,Likely Neutral,NA,COF,NA,NA,NA,NA,21996744 +OncoKB,IDH1,Likely Oncogenic,NA,Likely SOF,NA,NA,NA,NA,"25730874, 23630074, 19935646" +OncoKB,IDH2,Likely Oncogenic,NA,Likely SOF,NA,NA,NA,NA,"27147599, 20171147" +OncoKB,IDH2,Oncogenic,NA,SOF,NA,NA,NA,NA,"20171147, 25043045" +OncoKB,IDH2,Likely Oncogenic,NA,Likely SOF,NA,NA,NA,NA,"21641335, 20171147" +OncoKB,IDH2,Oncogenic,NA,SOF,NA,NA,NA,NA,"20692206, 23264629, 20171147, 25043045, 24440599, 20847235" +OncoKB,IDH2,Oncogenic,NA,SOF,NA,NA,NA,NA,"23264629, 20171147" +OncoKB,XPO1,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"21741593, 21642962, 27312795, 26619011, 27479820" +OncoKB,XPO1,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,"27680702, 23034282" +OncoKB,XRCC2,Likely Neutral,NA,Likely LOF,NA,NA,NA,NA,"22464251, 14678973, 10517641" +OncoKB,XRCC2,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,12023985 +OncoKB,XRCC2,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"22464251, 14678973, 10517641" +OncoKB,CREBBP,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,"11691934, 21390130" +OncoKB,CREBBP,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,21390130 +OncoKB,CREBBP,Likely Neutral,NA,COF,NA,NA,NA,NA,21390130 +OncoKB,CREBBP,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,21390130 +OncoKB,CREBBP,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,21390130 +OncoKB,CREBBP,Likely Neutral,NA,COF,NA,NA,NA,NA,21390130 +OncoKB,CREBBP,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,21390130 +OncoKB,DIS3,Oncogenic,NA,LOF,NA,NA,NA,NA,"26193331, 24150935" +OncoKB,AR,Oncogenic,NA,GOF,NA,NA,NA,NA,"23779130, 23842682, 23580326" +OncoKB,AR,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,25500996 +OncoKB,AR,Likely Neutral,NA,LOF,NA,NA,NA,NA,22403669 +OncoKB,AR,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,25500996 +OncoKB,AR,Oncogenic,NA,GOF,NA,NA,NA,NA,12517791 +OncoKB,AR,Oncogenic,NA,GOF,NA,NA,NA,NA,"9092797, 2260966, 10363963, 9815822, 25320358" +OncoKB,AR,Likely Neutral,NA,Likely LOF,NA,NA,NA,NA,25500996 +OncoKB,AR,Oncogenic,NA,GOF,NA,NA,NA,NA,"9092797, 2260966, 9815822" +OncoKB,AR,Likely Neutral,NA,Likely LOF,NA,NA,NA,NA,25500996 +OncoKB,AR,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,25500996 +OncoKB,AR,Oncogenic,NA,GOF,NA,NA,NA,NA,"7795646, 7511045, 11306464, 12888829, 14702632, 10496349" +OncoKB,AR,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"23779130, 2384268" +OncoKB,AR,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,"12801573, 23637914, 24737579" +OncoKB,AR,Oncogenic,NA,GOF,NA,NA,NA,NA,"20823238, 19117982, 24449822, 22014572, 23851510, 21552559, 19244107, 20644256" +OncoKB,AR,Oncogenic,NA,GOF,NA,NA,NA,NA,"11956172, 10835690" +OncoKB,AR,Oncogenic,NA,GOF,NA,NA,NA,NA,12517791 +OncoKB,AR,Oncogenic,NA,GOF,NA,NA,NA,NA,"9092797, 9815822" +OncoKB,AR,Likely Neutral,NA,COF,NA,NA,NA,NA,25500996 +OncoKB,AR,Likely Neutral,NA,Likely LOF,NA,NA,NA,NA,"25500996, 11422119" +OncoKB,AR,Oncogenic,NA,GOF,NA,NA,NA,NA,"20823238, 19117982, 24449822, 22014572, 23851510, 21552559, 19244107, 20644256" +OncoKB,AR,Likely Neutral,NA,COF,NA,NA,NA,NA,25500996 +OncoKB,AR,Likely Neutral,NA,COF,NA,NA,NA,NA,25500996 +OncoKB,ARAF,Oncogenic,NA,GOF,NA,NA,NA,NA,"24569458, 15520807" +OncoKB,ARAF,Oncogenic,NA,GOF,NA,NA,NA,NA,24652991 +OncoKB,ARAF,Oncogenic,NA,GOF,NA,NA,NA,NA,"24569458, 15520807" +OncoKB,ARAF,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,"25608663, 24569458" +OncoKB,ARAF,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"24569458, 26566875, 15520807" +OncoKB,ARAF,Oncogenic,NA,GOF,NA,NA,NA,NA,24652991 +OncoKB,ARAF,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,"24569458, 15520807" +OncoKB,ARAF,Oncogenic,NA,GOF,NA,NA,NA,NA,"25608663, 15520807" +OncoKB,RHOA,Oncogenic,NA,LOF,NA,NA,NA,NA,"24413737, 24584070" +OncoKB,RHOA,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"26619011, 9482732" +OncoKB,RHOA,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"19147561, 15993039" +OncoKB,RHOA,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,24816255 +OncoKB,RHOA,Oncogenic,NA,GOF,NA,NA,NA,NA,"10213513, 15448013, 25104222" +OncoKB,RHOA,Oncogenic,NA,GOF,NA,NA,NA,NA,"10213513, 15448013, 25104222" +OncoKB,RHOA,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"26619011, 9565577" +OncoKB,RHOA,Likely Oncogenic,NA,Likely SOF,NA,NA,NA,NA,"24398689, 26619011" +OncoKB,RHOA,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"26619011, 9482732" +OncoKB,RHOA,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"26619011, 9565577" +OncoKB,RHOA,Oncogenic,NA,LOF,NA,NA,NA,NA,24816253 +OncoKB,RHOA,Oncogenic,NA,LOF,NA,NA,NA,NA,"9482732, 24816253, 24816255" +OncoKB,RHOA,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"26619011, 9482732" +OncoKB,RHOA,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,"22491204, 12221096, 16472675" +OncoKB,RHOA,Likely Neutral,NA,LOF,NA,NA,NA,NA,"24584070, 19515453" +OncoKB,RHOA,Likely Oncogenic,NA,Likely SOF,NA,NA,NA,NA,"26619011, 9482732" +OncoKB,RHOA,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,"19147561, 24584070" +OncoKB,RHOA,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,25044415 +OncoKB,NCOR1,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"21102521, 7566114" +OncoKB,PPP2R1A,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"17174897, 17086192, 18922469" +OncoKB,PPP2R1A,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"21435433, 17174897, 17086192, 18922469" +OncoKB,PPP2R1A,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"21435433, 17174897, 17086192, 18922469" +OncoKB,PPP2R1A,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"17174897, 17086192, 18922469" +OncoKB,PPP2R1A,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"17174897, 17086192, 18922469" +OncoKB,PPP2R1A,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"21435433, 17174897, 17086192, 18922469" +OncoKB,PPP2R1A,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"17174897, 17086192, 18922469" +OncoKB,PPP2R1A,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"21435433, 17174897, 17086192, 18922469" +OncoKB,PPP2R1A,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,"21435433, 17174897, 17086192, 18922469, 27272709" +OncoKB,PPP2R1A,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,"17174897, 17086192, 18922469" +OncoKB,PPP2R1A,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"21435433, 17174897, 17086192, 18922469, 26168268" +OncoKB,PPP2R1A,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,"17174897, 17086192, 18922469" +OncoKB,PPP2R1A,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"17174897, 17086192, 18922469" +OncoKB,PPP2R1A,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"17174897, 17086192, 18922469" +OncoKB,SETD2,Oncogenic,NA,LOF,NA,NA,NA,NA,27282254 +OncoKB,SETD2,Oncogenic,NA,LOF,NA,NA,NA,NA,27528607 +OncoKB,SETD2,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"24509477, 25728682, 23417712" +OncoKB,IGF1R,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,23045302 +OncoKB,IGF1R,Likely Neutral,NA,Likely LOF,NA,NA,NA,NA,20103656 +OncoKB,IGF1R,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,22778948 +OncoKB,IGF1R,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,22778948 +OncoKB,PPP6C,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,23729733 +OncoKB,PPP6C,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,23729733 +OncoKB,PPP6C,Oncogenic,NA,LOF,NA,NA,NA,NA,23729733 +OncoKB,PPP6C,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,23729733 +OncoKB,CTCF,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"11782357, 24794443, 26619011" +OncoKB,CTCF,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"11782357, 24794443, 26619011" +OncoKB,CTCF,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"11782357, 24794443, 26619011" +OncoKB,CTCF,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"26330387, 24130125, 19568526" +OncoKB,CTCF,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"25079317, 24130125, 23636398" +OncoKB,CTCF,Likely Oncogenic,NA,SOF,NA,NA,NA,NA,11782357 +OncoKB,IKBKE,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"17574021, 25365225" +OncoKB,MTOR,Oncogenic,NA,GOF,NA,NA,NA,NA,22397650 +OncoKB,MTOR,Oncogenic,NA,GOF,NA,NA,NA,NA,"20190810, 24631838, 26255626" +OncoKB,MTOR,Likely Neutral,NA,COF,NA,NA,NA,NA,20190810 +OncoKB,MTOR,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,23322780 +OncoKB,MTOR,Oncogenic,NA,GOF,NA,NA,NA,NA,27482884 +OncoKB,MTOR,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,24631838 +OncoKB,MTOR,Oncogenic,NA,GOF,NA,NA,NA,NA,24631838 +OncoKB,MTOR,Likely Neutral,NA,COF,NA,NA,NA,NA,24631838 +OncoKB,MTOR,Oncogenic,NA,GOF,NA,NA,NA,NA,24625776 +OncoKB,MTOR,Oncogenic,NA,GOF,NA,NA,NA,NA,24631838 +OncoKB,MTOR,Likely Neutral,NA,COF,NA,NA,NA,NA,24631838 +OncoKB,MTOR,Likely Neutral,NA,COF,NA,NA,NA,NA,24631838 +OncoKB,MTOR,Oncogenic,NA,GOF,NA,NA,NA,NA,27482884 +OncoKB,MTOR,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,27713405 +OncoKB,MTOR,Oncogenic,NA,GOF,NA,NA,NA,NA,24631838 +OncoKB,MTOR,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,24631838 +OncoKB,MTOR,Likely Neutral,NA,COF,NA,NA,NA,NA,24631838 +OncoKB,MTOR,Likely Neutral,NA,COF,NA,NA,NA,NA,20190810 +OncoKB,MTOR,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,27279227 +OncoKB,MTOR,Oncogenic,NA,GOF,NA,NA,NA,NA,24631838 +OncoKB,MTOR,Likely Neutral,NA,COF,NA,NA,NA,NA,24631838 +OncoKB,MTOR,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,24631838 +OncoKB,MTOR,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,24625776 +OncoKB,MTOR,Oncogenic,NA,GOF,NA,NA,NA,NA,24631838 +OncoKB,MTOR,Likely Neutral,NA,COF,NA,NA,NA,NA,24631838 +OncoKB,MTOR,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"24631838, 26255626" +OncoKB,MTOR,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"24631838, 26619011" +OncoKB,MTOR,Oncogenic,NA,GOF,NA,NA,NA,NA,"24631838, 26255626" +OncoKB,MTOR,Likely Neutral,NA,COF,NA,NA,NA,NA,24631838 +OncoKB,MTOR,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"24631838, 26255626" +OncoKB,MTOR,Oncogenic,NA,GOF,NA,NA,NA,NA,24622468 +OncoKB,MTOR,Likely Neutral,NA,COF,NA,NA,NA,NA,24631838 +OncoKB,MTOR,Oncogenic,NA,GOF,NA,NA,NA,NA,"20190810, 24631838, 26255626" +OncoKB,MTOR,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,24631838 +OncoKB,MTOR,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"23322780, 22460905" +OncoKB,MTOR,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,23322780 +OncoKB,MTOR,Likely Neutral,NA,COF,NA,NA,NA,NA,24631838 +OncoKB,MTOR,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,24631838 +OncoKB,MTOR,Oncogenic,NA,GOF,NA,NA,NA,NA,24631838 +OncoKB,MTOR,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,27279227 +OncoKB,MTOR,Likely Neutral,NA,COF,NA,NA,NA,NA,24631838 +OncoKB,MTOR,Oncogenic,NA,GOF,NA,NA,NA,NA,24631838 +OncoKB,MTOR,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,24631838 +OncoKB,MTOR,Oncogenic,NA,GOF,NA,NA,NA,NA,"20190810, 24631838, 24336570" +OncoKB,MTOR,Oncogenic,NA,GOF,NA,NA,NA,NA,"24631838, 26255626" +OncoKB,MTOR,Likely Neutral,NA,COF,NA,NA,NA,NA,24631838 +OncoKB,MTOR,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,27279227 +OncoKB,MTOR,Oncogenic,NA,GOF,NA,NA,NA,NA,"24631838, 26255626" +OncoKB,MTOR,Likely Neutral,NA,COF,NA,NA,NA,NA,24631838 +OncoKB,MTOR,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,26432419 +OncoKB,TET1,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"21057493, 22156206, 19372391" +OncoKB,TET1,Oncogenic,NA,GOF,NA,NA,NA,NA,"19144982, 12646957, 23818607, 24323992" +OncoKB,TET1,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"21625234, 19420352, 25867473" +OncoKB,SMARCA4,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"24658002, 24658001, 24658004, 25060813, 18301784" +OncoKB,SMARCA4,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,"26842758, 23698369" +OncoKB,SMARCA4,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,20137775 +OncoKB,SMARCA4,Oncogenic,NA,LOF,NA,NA,NA,NA,"24658001, 24658004" +OncoKB,SMARCA4,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"21520050, 23139211, 18381774, 11481457, 26942101, 11163203" +OncoKB,SMARCA4,Oncogenic,NA,LOF,NA,NA,NA,NA,"24658002, 24658004" +OncoKB,SMARCA4,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,23698369 +OncoKB,SMARCB1,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"23620515, 12138206, 9671307, 23435428, 21076395" +OncoKB,SMARCB1,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"11313485, 10521299, 11095756, 23074045, 9892189, 12450796, 22797305, 11263494" +OncoKB,FOXP1,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,25329375 +OncoKB,FOXP1,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,26647308 +OncoKB,SMO,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"25759020, 25759019" +OncoKB,SMO,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,"2575902, 25759020, 25759019, 25199678" +OncoKB,SMO,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,25759019 +OncoKB,SMO,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,"2575902, 25759020, 25759019, 25199678" +OncoKB,SMO,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,"25759020, 25759019, 25199678" +OncoKB,SMO,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,"2575902, 25759020, 25759019, 25199678" +OncoKB,SMO,Likely Neutral,NA,COF,NA,NA,NA,NA,21123452 +OncoKB,SMO,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"25759020, 25759019" +OncoKB,SMO,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,25759019 +OncoKB,SMO,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"25759020, 25759019" +OncoKB,SMO,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,25759019 +OncoKB,SMO,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"25759020, 25759019" +OncoKB,SMO,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,19726788 +OncoKB,SMO,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,"2575902, 25759020, 25759019, 25199678" +OncoKB,SMO,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"16339184, 12499255" +OncoKB,SMO,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"25759020, 25759019" +OncoKB,SMO,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,"2575902, 25759020, 25759019, 25199678" +OncoKB,SMO,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,21123452 +OncoKB,SMO,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,"25759020, 23636324, 9422511" +OncoKB,SMO,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,"24202394, 26124204, 20215540" +OncoKB,SMO,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,25759020 +OncoKB,SMO,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"25801792, 26619011" +OncoKB,SMO,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,19726788 +OncoKB,CARD11,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,"25930198, 23149938" +OncoKB,CARD11,Oncogenic,NA,GOF,NA,NA,NA,NA,"23027925, 18323416, 26776161" +OncoKB,CARD11,Oncogenic,NA,GOF,NA,NA,NA,NA,"23027925, 18323416, 26776161" +OncoKB,CARD11,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,"20799731, 23149938" +OncoKB,CARD11,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,"20799731, 23149938" +OncoKB,CARD11,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,23179749 +OncoKB,CARD11,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,23179749 +OncoKB,CARD11,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,23027925 +OncoKB,CARD11,Oncogenic,NA,GOF,NA,NA,NA,NA,23149938 +OncoKB,CARD11,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,23027925 +OncoKB,CARD11,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,23027925 +OncoKB,CARD11,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,18323416 +OncoKB,CARD11,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,26551667 +OncoKB,CARD11,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,25921526 +OncoKB,MEF2B,Oncogenic,NA,LOF,NA,NA,NA,NA,"23974956, 26245647" +OncoKB,MEF2B,Oncogenic,NA,LOF,NA,NA,NA,NA,23974956 +OncoKB,MEF2B,Oncogenic,NA,LOF,NA,NA,NA,NA,23974956 +OncoKB,MEF2B,Oncogenic,NA,LOF,NA,NA,NA,NA,23974956 +OncoKB,MEF2B,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,26245647 +OncoKB,MEF2B,Oncogenic,NA,GOF,NA,NA,NA,NA,"23974956, 26245647" +OncoKB,CTLA4,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"15018649, 11976786, 20064370, 10082437, 8989248, 18528295, 9459504, 12244107" +OncoKB,ATM,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,"18634022, 9463314" +OncoKB,ATM,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"15928302, 16832357, 16998505" +OncoKB,ATM,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"21514219, 18807267" +OncoKB,ATM,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,"9733515, 27304073" +OncoKB,ATM,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"21993670, 16014569" +OncoKB,ATM,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,"9733515, 27304073" +OncoKB,ATM,Likely Neutral,NA,COF,NA,NA,NA,NA,"20396981, 18264724, 20799949" +OncoKB,NUP93,Likely Neutral,NA,COF,NA,NA,NA,NA,26878725 +OncoKB,NUP93,Likely Neutral,NA,COF,NA,NA,NA,NA,26878725 +OncoKB,NUP93,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,26878725 +OncoKB,NUP93,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,26878725 +OncoKB,MAPK1,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,22961667 +OncoKB,MAPK1,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,"24390348, 18813840, 25320010, 26551667, 26181029, 15999996, 21098038, 16324895, 16051177" +OncoKB,CTNNB1,Oncogenic,NA,GOF,NA,NA,NA,NA,12799363 +OncoKB,CTNNB1,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,"9635572, 15829978, 9065402" +OncoKB,CTNNB1,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,"9635572, 10671680, 9065402" +OncoKB,CTNNB1,Oncogenic,NA,GOF,NA,NA,NA,NA,"9635572, 24735922, 18757411, 9065402" +OncoKB,CTNNB1,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,"20606007, 9635572, 9065402" +OncoKB,CTNNB1,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,"9635572, 24735922, 18282277, 9065402" +OncoKB,CTNNB1,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,"9635572, 15064718, 9065402" +OncoKB,CTNNB1,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,"9635572, 9537226, 9065402" +OncoKB,CTNNB1,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,"9635572, 15064718, 9065402" +OncoKB,CTNNB1,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"9635572, 15829978, 27543871, 18757411, 19582367, 9065402" +OncoKB,CTNNB1,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,"9635572, 18282277, 9065402" +OncoKB,CTNNB1,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,"9635572, 24735922, 18282277, 9065402" +OncoKB,CTNNB1,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,"15579438, 9635572, 9065402" +OncoKB,CTNNB1,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,"9635572, 24735922, 18282277, 9065402" +OncoKB,CTNNB1,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,15829978 +OncoKB,CTNNB1,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,"12375019, 9635572, 24735922, 18282277, 9065402, 10665646" +OncoKB,CTNNB1,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,"9635572, 15064718, 9065402" +OncoKB,CTNNB1,Oncogenic,NA,GOF,NA,NA,NA,NA,15829978 +OncoKB,CTNNB1,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,"9635572, 18282277, 26686699, 9065402" +OncoKB,CTNNB1,Oncogenic,NA,GOF,NA,NA,NA,NA,"9635572, 19582367, 9065402" +OncoKB,CTNNB1,Oncogenic,NA,GOF,NA,NA,NA,NA,"9635572, 24735922, 12799363, 9065402" +OncoKB,CTNNB1,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,"15579438, 9635572, 24735922, 9065402" +OncoKB,CTNNB1,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,"9635572, 24735922, 9065402" +OncoKB,CTNNB1,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,"9635572, 15064718, 9065402" +OncoKB,CTNNB1,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,"15579438, 9635572, 9065402" +OncoKB,CTNNB1,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,"9635572, 9065402, 9419974" +OncoKB,CTNNB1,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,"9635572, 22815287, 20303878, 9537226, 9065403, 9065402" +OncoKB,CTNNB1,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,"9635572, 10671680, 9671767, 9065402" +OncoKB,MAP2K1,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,"17981815, 16439621" +OncoKB,MAP2K1,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,24265153 +OncoKB,MAP2K1,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,19915144 +OncoKB,MAP2K1,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,26566875 +OncoKB,MAP2K1,Oncogenic,NA,GOF,NA,NA,NA,NA,"24982505, 22327936" +OncoKB,MAP2K1,Oncogenic,NA,GOF,NA,NA,NA,NA,"25351745, 18060073" +OncoKB,MAP2K1,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,"21705440, 19915144, 26399658" +OncoKB,MAP2K1,Oncogenic,NA,GOF,NA,NA,NA,NA,"25351745, 22197931" +OncoKB,MAP2K1,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,"19915144, 12370306" +OncoKB,MAP2K1,Oncogenic,NA,GOF,NA,NA,NA,NA,"24265153, 22197931, 25370473" +OncoKB,MAP2K1,Likely Neutral,NA,COF,NA,NA,NA,NA,22197931 +OncoKB,MAP2K1,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,"19915144, 25370473" +OncoKB,MAP2K1,Oncogenic,NA,GOF,NA,NA,NA,NA,22327936 +OncoKB,MAP2K1,Oncogenic,NA,GOF,NA,NA,NA,NA,"26566875, 25370473, 24241536" +OncoKB,MAP2K1,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,26644315 +OncoKB,MAP2K1,Likely Neutral,NA,COF,NA,NA,NA,NA,26566875 +OncoKB,MAP2K1,Oncogenic,NA,GOF,NA,NA,NA,NA,26324360 +OncoKB,MAP2K1,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,25351745 +OncoKB,MAP2K1,Oncogenic,NA,GOF,NA,NA,NA,NA,"19915144, 25351745, 22327936, 26566875" +OncoKB,MAP2K1,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,26566875 +OncoKB,MAP2K1,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,"18060073, 26566875" +OncoKB,MAP2K1,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,"26399658, 26684394" +OncoKB,MAP2K1,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,19915144 +OncoKB,MAP2K1,Oncogenic,NA,GOF,NA,NA,NA,NA,"25351745, 21383288, 22197931, 26582713, 26324360, 24241536" +OncoKB,MAP2K1,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,"24448821, 25351745, 21383288" +OncoKB,MAP2K1,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,"19915144, 26399658" +OncoKB,MAP2K1,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,12370306 +OncoKB,MAP2K1,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,26566875 +OncoKB,MAP2K1,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,26566875 +OncoKB,MAP2K1,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,17981815 +OncoKB,MAP2K1,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,19915144 +OncoKB,MAP2K1,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,12370306 +OncoKB,MAP2K1,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,19915144 +OncoKB,MAP2K1,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,"17981815, 16439621" +OncoKB,MAP2K1,Oncogenic,NA,GOF,NA,NA,NA,NA,"17981815, 16439621" +OncoKB,MAP2K1,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,22327936 +OncoKB,MAP2K1,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,22327936 +OncoKB,MAP2K1,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,22389471 +OncoKB,MAP2K1,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,12370306 +OncoKB,MAP2K1,Likely Neutral,NA,COF,NA,NA,NA,NA,22389471 +OncoKB,MAP2K1,Oncogenic,NA,GOF,NA,NA,NA,NA,"25351745, 18632602, 26566875" +OncoKB,MAP2K1,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,25370473 +OncoKB,MAP2K1,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,24265153 +OncoKB,MAP2K1,Likely Neutral,NA,COF,NA,NA,NA,NA,26566875 +OncoKB,MAP2K1,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,26566875 +OncoKB,MAP2K1,Likely Neutral,NA,LOF,NA,NA,NA,NA,"22177953, 10567369, 16439621" +OncoKB,MAP2K1,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,26566875 +OncoKB,MAP2K2,Oncogenic,NA,GOF,NA,NA,NA,NA,"24265154, 24055054" +OncoKB,MAP2K2,Oncogenic,NA,GOF,NA,NA,NA,NA,"24265153, 21383288" +OncoKB,MAP2K2,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"18042262, 18456719, 16439621" +OncoKB,MAP2K2,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,"19376813, 22177953, 16439621" +OncoKB,MAP2K2,Oncogenic,NA,GOF,NA,NA,NA,NA,"24265153, 21383288" +OncoKB,MAP2K2,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,16439621 +OncoKB,MAP2K2,Oncogenic,NA,GOF,NA,NA,NA,NA,22197931 +OncoKB,MAP2K2,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,16439621 +OncoKB,MAP2K2,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,16439621 +OncoKB,MAP2K2,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"18042262, 18456719, 16439621" +OncoKB,MAP2K2,Oncogenic,NA,GOF,NA,NA,NA,NA,"25487361, 24265153" +OncoKB,MAP2K2,Oncogenic,NA,GOF,NA,NA,NA,NA,"24265153, 21383288" +OncoKB,SPEN,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,26297734 +OncoKB,STAG2,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"22417201, 21852505, 24121789, 25010205" +OncoKB,IL7R,Oncogenic,NA,GOF,NA,NA,NA,NA,21892159 +OncoKB,SOS1,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,17143285 +OncoKB,SOS1,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,"21041952, 17143285" +OncoKB,SOS1,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,27304678 +OncoKB,SOS1,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,"27304678, 17143285, 25712082, 24297905" +OncoKB,SOS1,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,27304678 +OncoKB,SOS1,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,27304678 +OncoKB,MYC,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,"10378696, 20399964, 21266350, 18642118, 16934487, 19029958, 10706881, 22464321" +OncoKB,MYC,Oncogenic,NA,GOF,NA,NA,NA,NA,"10378696, 22333947, 16934487, 19029958, 22464321" +OncoKB,MYC,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"20713710, 26619011, 10825194" +OncoKB,MYC,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,"24696454, 20691906" +OncoKB,MYC,Oncogenic,NA,GOF,NA,NA,NA,NA,"19351371, 10378696, 24957271, 7731690, 8502472, 22333947, 16934487, 21887927, 19029958, 8816814, 19246886, 22464321" +OncoKB,MYC,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"22134537, 24298051" +OncoKB,MYC,Oncogenic,NA,GOF,NA,NA,NA,NA,"20164920, 10378696, 16934487, 15083194, 19029958, 22464321" +OncoKB,MYC,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"22333947, 16934487" +OncoKB,MYC,Oncogenic,NA,GOF,NA,NA,NA,NA,"10378696, 11034608, 7731690, 8502472, 22333947, 16934487, 19029958, 8816814, 22464321" +OncoKB,MYCN,Oncogenic,NA,GOF,NA,NA,NA,NA,"12612655, 16116477, 22035742, 22139329, 23091029, 21533284, 15013217, 9214616" +OncoKB,MYCN,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"23334666, 24086065" +OncoKB,SOX9,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"10446171, 12783851, 9002675" +OncoKB,SOX9,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,10446171 +OncoKB,SOX9,Likely Neutral,NA,COF,NA,NA,NA,NA,10446171 +OncoKB,SOX9,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"10446171, 27248473" +OncoKB,SOX9,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,27429045 +OncoKB,SOX9,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,10446171 +OncoKB,SOX9,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,10446171 +OncoKB,SOX9,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,15694126 +OncoKB,TET2,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,24315485 +OncoKB,TET2,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,24315485 +OncoKB,TET2,Likely Neutral,NA,COF,NA,NA,NA,NA,24315485 +OncoKB,TET2,Likely Neutral,NA,COF,NA,NA,NA,NA,24315485 +OncoKB,TET2,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,24315485 +OncoKB,TET2,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,24315485 +OncoKB,TET2,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,24315485 +OncoKB,TET2,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,24315485 +OncoKB,TET2,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"21057493, 24315485" +OncoKB,TET2,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,24315485 +OncoKB,TET2,Likely Neutral,NA,COF,NA,NA,NA,NA,24315485 +OncoKB,TET2,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,24315485 +OncoKB,TET2,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,24315485 +OncoKB,TET2,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,"21625234, 25224413, 21723200, 22017486" +OncoKB,TET2,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,24315485 +OncoKB,TET2,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,24315485 +OncoKB,MYD88,Oncogenic,NA,GOF,NA,NA,NA,NA,"25723115, 26111727" +OncoKB,MYD88,Oncogenic,NA,GOF,NA,NA,NA,NA,25359991 +OncoKB,MYD88,Oncogenic,NA,GOF,NA,NA,NA,NA,"24534189, 2179087" +OncoKB,AGO2,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,17891150 +OncoKB,AGO2,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"18787018, 23775134" +OncoKB,AGO2,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"20198652, 14749716" +OncoKB,AGO2,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,17891150 +OncoKB,AGO2,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,17891150 +OncoKB,AGO2,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,17891150 +OncoKB,KMT2B,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,"25998713, 16540515, 17429066" +OncoKB,ATR,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"10691732, 15282542" +OncoKB,ATRX,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"21719641, 8968741, 24148618, 15591283, 14592816, 18409179, 17609377" +OncoKB,ATRX,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"21719641, 27311324, 24148618, 26741321, 23904111" +OncoKB,CDK12,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,"24554720, 21720365, 25712099" +OncoKB,CDK12,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,"20932292, 26658019, 21097718" +OncoKB,CDK12,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"24554720, 25712099" +OncoKB,CDK12,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"24554720, 21720365, 25712099, 26787825" +OncoKB,CDK12,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,"24554720, 25712099" +OncoKB,CDK12,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,"24554720, 21720365, 25712099" +OncoKB,CDK12,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"24554720, 25712099, 24240700" +OncoKB,CDK12,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,"24554720, 21720365, 25712099" +OncoKB,CDK12,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,"24554720, 25712099" +OncoKB,CDK12,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,24554720 +OncoKB,CDK12,Likely Neutral,NA,COF,NA,NA,NA,NA,"24554720, 21720365, 25712099" +OncoKB,AXL,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"23264849, 22751098, 25337673, 25966280" +OncoKB,MYOD1,Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"24793135, 1329087" +OncoKB,B2M,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,22137796 +OncoKB,B2M,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,24947018 +OncoKB,B2M,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,22137796 +OncoKB,B2M,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"25594174, 25294904, 22833104, 16730261, 22137796, 23784959, 9637706, 1898655" +OncoKB,B2M,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,"24947018, 22137796" +OncoKB,B2M,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,"11894933, 24947018" +OncoKB,B2M,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"25594174, 25294904, 22833104, 16730261, 22137796, 23784959, 9637706, 1898655" +OncoKB,SRC,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"24788409, 11114744, 15060621, 22589274" +OncoKB,SRC,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,9988270 +OncoKB,GATA3,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"20154722, 11441075, 18471881, 16087702, 24448324, 20855495, 21779441" +OncoKB,GATA3,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,26268891 +OncoKB,GATA3,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"10935639, 15361840, 23426732, 26637396, 24758297, 7829479" +OncoKB,GATA3,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"23426732, 18242514, 26637396, 27588951, 24758297" +OncoKB,BARD1,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA, +OncoKB,BARD1,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"20029420, 17848578, 20842729" +OncoKB,CCND1,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,"17299095, 9832503, 16732330, 9926916" +OncoKB,CCND1,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,"24145436, 27713153" +OncoKB,CCND1,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,"24145436, 27713153" +OncoKB,CCND1,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"9832503, 16732330" +OncoKB,CCND1,Oncogenic,NA,GOF,NA,NA,NA,NA,"16732330, 11124803" +OncoKB,CCND1,Oncogenic,NA,GOF,NA,NA,NA,NA,"9832503, 16732330" +OncoKB,CCND1,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"16732330, 12955092, 12615961" +OncoKB,CCND1,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,"14514791, 25596256, 16690963, 16402392" +OncoKB,CCND1,Oncogenic,NA,GOF,NA,NA,NA,NA,"9832503, 16732330, 12955092" +OncoKB,CCND1,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,"16732330, 12615961" +OncoKB,CCND1,Oncogenic,NA,GOF,NA,NA,NA,NA,"9832503, 20164920, 20074063, 8114739, 10508165, 11486031, 16393691, 9792703, 19020303, 21734724" +OncoKB,CCND1,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"28483394, 19823025" +OncoKB,CCND1,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"9832503, 16732330" +OncoKB,CCND1,Oncogenic,NA,GOF,NA,NA,NA,NA,"9832503, 16732330, 11124803" +OncoKB,BCL2,Oncogenic,NA,GOF,NA,NA,NA,NA,"23939148, 3500184, 18202696, 3874430, 10910891, 2875799, 23892979" +OncoKB,KEAP1,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,24322982 +OncoKB,KEAP1,Oncogenic,NA,LOF,NA,NA,NA,NA,18316592 +OncoKB,KEAP1,Oncogenic,NA,LOF,NA,NA,NA,NA,24322982 +OncoKB,KEAP1,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,17822677 +OncoKB,KEAP1,Oncogenic,NA,LOF,NA,NA,NA,NA,24322982 +OncoKB,KEAP1,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"17020408, 24142871" +OncoKB,KEAP1,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"17020408, 24142871, 24322982" +OncoKB,KEAP1,Oncogenic,NA,LOF,NA,NA,NA,NA,18316592 +OncoKB,KEAP1,Oncogenic,NA,LOF,NA,NA,NA,NA,18316592 +OncoKB,KEAP1,Oncogenic,NA,LOF,NA,NA,NA,NA,24322982 +OncoKB,KEAP1,Oncogenic,NA,LOF,NA,NA,NA,NA,24322982 +OncoKB,KEAP1,Oncogenic,NA,LOF,NA,NA,NA,NA,24322982 +OncoKB,KEAP1,Oncogenic,NA,LOF,NA,NA,NA,NA,23912815 +OncoKB,KEAP1,Oncogenic,NA,LOF,NA,NA,NA,NA,24322982 +OncoKB,KEAP1,Oncogenic,NA,LOF,NA,NA,NA,NA,19818716 +OncoKB,KEAP1,Oncogenic,NA,LOF,NA,NA,NA,NA,24322982 +OncoKB,PTCH1,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,8782823 +OncoKB,PTCH1,Likely Neutral,NA,COF,NA,NA,NA,NA,24368541 +OncoKB,PTEN,Oncogenic,NA,LOF,NA,NA,NA,NA,21828076 +OncoKB,PTEN,Oncogenic,NA,LOF,NA,NA,NA,NA,11051241 +OncoKB,PTEN,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"21828076, 26619011" +OncoKB,PTEN,Oncogenic,NA,LOF,NA,NA,NA,NA,21828076 +OncoKB,PTEN,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,10866302 +OncoKB,PTEN,Oncogenic,NA,LOF,NA,NA,NA,NA,"10866302, 24721394" +OncoKB,PTEN,Oncogenic,NA,LOF,NA,NA,NA,NA,21828076 +OncoKB,PTEN,Oncogenic,NA,LOF,NA,NA,NA,NA,"9467011, 10866302" +OncoKB,PTEN,Oncogenic,NA,LOF,NA,NA,NA,NA,"9467011, 21828076" +OncoKB,PTEN,Oncogenic,NA,LOF,NA,NA,NA,NA,21828076 +OncoKB,PTEN,Oncogenic,NA,LOF,NA,NA,NA,NA,19329485 +OncoKB,PTEN,Oncogenic,NA,LOF,NA,NA,NA,NA,21828076 +OncoKB,PTEN,Oncogenic,NA,LOF,NA,NA,NA,NA,21828076 +OncoKB,PTEN,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,25527629 +OncoKB,PTEN,Oncogenic,NA,LOF,NA,NA,NA,NA,21828076 +OncoKB,PTEN,Oncogenic,NA,LOF,NA,NA,NA,NA,21828076 +OncoKB,PTEN,Oncogenic,NA,LOF,NA,NA,NA,NA,"20926450, 21828076" +OncoKB,PTEN,Oncogenic,NA,LOF,NA,NA,NA,NA,21828076 +OncoKB,PTEN,Oncogenic,NA,LOF,NA,NA,NA,NA,21828076 +OncoKB,PTEN,Likely Neutral,NA,COF,NA,NA,NA,NA,21828076 +OncoKB,PTEN,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,17213812 +OncoKB,PTEN,Oncogenic,NA,LOF,NA,NA,NA,NA,10866302 +OncoKB,PTEN,Oncogenic,NA,LOF,NA,NA,NA,NA,21828076 +OncoKB,PTEN,Oncogenic,NA,LOF,NA,NA,NA,NA,21828076 +OncoKB,PTEN,Oncogenic,NA,LOF,NA,NA,NA,NA,21828076 +OncoKB,PTEN,Oncogenic,NA,LOF,NA,NA,NA,NA,21828076 +OncoKB,PTEN,Oncogenic,NA,LOF,NA,NA,NA,NA,"9467011, 21828076, 10866302" +OncoKB,PTEN,Oncogenic,NA,LOF,NA,NA,NA,NA,24721394 +OncoKB,PTEN,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,10866302 +OncoKB,PTEN,Oncogenic,NA,LOF,NA,NA,NA,NA,21828076 +OncoKB,PTEN,Oncogenic,NA,LOF,NA,NA,NA,NA,10468583 +OncoKB,PTEN,Oncogenic,NA,LOF,NA,NA,NA,NA,"11051241, 10866302" +OncoKB,PTEN,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,10866302 +OncoKB,PTEN,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,10866302 +OncoKB,PTEN,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,10866302 +OncoKB,PTEN,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,21828076 +OncoKB,PTEN,Oncogenic,NA,LOF,NA,NA,NA,NA,17213812 +OncoKB,PTEN,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,17942903 +OncoKB,PTEN,Oncogenic,NA,LOF,NA,NA,NA,NA,21828076 +OncoKB,PTEN,Oncogenic,NA,LOF,NA,NA,NA,NA,10866302 +OncoKB,PTEN,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,10866302 +OncoKB,PTEN,Likely Neutral,NA,COF,NA,NA,NA,NA,21828076 +OncoKB,PTEN,Oncogenic,NA,LOF,NA,NA,NA,NA,25527629 +OncoKB,PTEN,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,"17213812, 10866302" +OncoKB,PTEN,Oncogenic,NA,LOF,NA,NA,NA,NA,"25527629, 10866302" +OncoKB,PTEN,Oncogenic,NA,LOF,NA,NA,NA,NA,"20926450, 19457929" +OncoKB,PTEN,Oncogenic,NA,LOF,NA,NA,NA,NA,17213812 +OncoKB,PTEN,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,10866302 +OncoKB,PTEN,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,10866302 +OncoKB,PTEN,Oncogenic,NA,LOF,NA,NA,NA,NA,21828076 +OncoKB,PTEN,Oncogenic,NA,LOF,NA,NA,NA,NA,21828076 +OncoKB,PTEN,Oncogenic,NA,GOF,NA,NA,NA,NA,17213812 +OncoKB,PTEN,Oncogenic,NA,LOF,NA,NA,NA,NA,23475934 +OncoKB,PTEN,Oncogenic,NA,LOF,NA,NA,NA,NA,21828076 +OncoKB,PTEN,Oncogenic,NA,LOF,NA,NA,NA,NA,21828076 +OncoKB,PTEN,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,10866302 +OncoKB,PTEN,Oncogenic,NA,LOF,NA,NA,NA,NA,"21828076, 25527629, 10866302, 9811831" +OncoKB,PTEN,Oncogenic,NA,LOF,NA,NA,NA,NA,21828076 +OncoKB,PTEN,Oncogenic,NA,LOF,NA,NA,NA,NA,"21828076, 25527629, 11051241, 10866302, 9811831" +OncoKB,PTEN,Oncogenic,NA,LOF,NA,NA,NA,NA,"21828076, 10866302" +OncoKB,PTEN,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,"25527629, 9811831" +OncoKB,PTEN,Oncogenic,NA,LOF,NA,NA,NA,NA,21828076 +OncoKB,PTEN,Oncogenic,NA,LOF,NA,NA,NA,NA,23840064 +OncoKB,PTEN,Oncogenic,NA,LOF,NA,NA,NA,NA,"9467011, 21828076, 25527629, 10866302, 9811831" +OncoKB,PTEN,Oncogenic,NA,LOF,NA,NA,NA,NA,"20926450, 19457929" +OncoKB,PTEN,Oncogenic,NA,LOF,NA,NA,NA,NA,21828076 +OncoKB,PTEN,Oncogenic,NA,LOF,NA,NA,NA,NA,21828076 +OncoKB,PTEN,Oncogenic,NA,LOF,NA,NA,NA,NA,25527629 +OncoKB,PTEN,Likely Neutral,NA,COF,NA,NA,NA,NA,21828076 +OncoKB,PTEN,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,10866302 +OncoKB,PTEN,Oncogenic,NA,LOF,NA,NA,NA,NA,21828076 +OncoKB,PTEN,Oncogenic,NA,LOF,NA,NA,NA,NA,"21828076, 25527629" +OncoKB,PTEN,Oncogenic,NA,LOF,NA,NA,NA,NA,21828076 +OncoKB,PTEN,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,10866302 +OncoKB,PTEN,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,"23840064, 9467011, 10866302" +OncoKB,PTEN,Oncogenic,NA,LOF,NA,NA,NA,NA,21828076 +OncoKB,PTEN,Oncogenic,NA,LOF,NA,NA,NA,NA,21828076 +OncoKB,PTEN,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,17213812 +OncoKB,PTEN,Oncogenic,NA,LOF,NA,NA,NA,NA,21828076 +OncoKB,PTEN,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,"24904117, 10560660, 22817889, 9326929, 24293293" +OncoKB,PTEN,Oncogenic,NA,LOF,NA,NA,NA,NA,21828076 +OncoKB,PTEN,Likely Neutral,NA,COF,NA,NA,NA,NA,19329485 +OncoKB,PTEN,Likely Neutral,NA,COF,NA,NA,NA,NA,21828076 +OncoKB,PTEN,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,10866302 +OncoKB,PTEN,Oncogenic,NA,LOF,NA,NA,NA,NA,21828076 +OncoKB,PTEN,Oncogenic,NA,LOF,NA,NA,NA,NA,21828076 +OncoKB,PTEN,Oncogenic,NA,LOF,NA,NA,NA,NA,10866302 +OncoKB,PTEN,Oncogenic,NA,LOF,NA,NA,NA,NA,"21828076, 11051241, 10866302" +OncoKB,PTEN,Oncogenic,NA,LOF,NA,NA,NA,NA,21828076 +OncoKB,PTEN,Oncogenic,NA,LOF,NA,NA,NA,NA,"21828076, 25527629" +OncoKB,PTEN,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,10866302 +OncoKB,PTEN,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,23475934 +OncoKB,PTEN,Oncogenic,NA,LOF,NA,NA,NA,NA,21828076 +OncoKB,PTEN,Likely Neutral,NA,COF,NA,NA,NA,NA,19329485 +OncoKB,PTEN,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,10866302 +OncoKB,PTEN,Oncogenic,NA,LOF,NA,NA,NA,NA,21828076 +OncoKB,PTEN,Oncogenic,NA,LOF,NA,NA,NA,NA,21828076 +OncoKB,PTEN,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"17218262, 11237521" +OncoKB,PTEN,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,10866302 +OncoKB,PTEN,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,25527629 +OncoKB,PTEN,Oncogenic,NA,LOF,NA,NA,NA,NA,21828076 +OncoKB,PTEN,Oncogenic,NA,LOF,NA,NA,NA,NA,21828076 +OncoKB,PTEN,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,10866302 +OncoKB,PTEN,Oncogenic,NA,LOF,NA,NA,NA,NA,21828076 +OncoKB,PTEN,Oncogenic,NA,LOF,NA,NA,NA,NA,21828076 +OncoKB,PTEN,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,10866302 +OncoKB,PTEN,Oncogenic,NA,LOF,NA,NA,NA,NA,21828076 +OncoKB,PTEN,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,10866302 +OncoKB,PTEN,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,"24904117, 10560660, 22817889, 9326929, 24293293" +OncoKB,PTEN,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,10866302 +OncoKB,PTEN,Oncogenic,NA,LOF,NA,NA,NA,NA,"21828076, 25527629" +OncoKB,PTEN,Oncogenic,NA,LOF,NA,NA,NA,NA,21828076 +OncoKB,PTEN,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,10866302 +OncoKB,PTEN,Oncogenic,NA,LOF,NA,NA,NA,NA,21828076 +OncoKB,PTEN,Oncogenic,NA,LOF,NA,NA,NA,NA,10866302 +OncoKB,PTEN,Oncogenic,NA,LOF,NA,NA,NA,NA,19329485 +OncoKB,PTEN,Oncogenic,NA,LOF,NA,NA,NA,NA,21828076 +OncoKB,PTEN,Oncogenic,NA,LOF,NA,NA,NA,NA,21828076 +OncoKB,PTEN,Oncogenic,NA,LOF,NA,NA,NA,NA,25447541 +OncoKB,PTEN,Oncogenic,NA,LOF,NA,NA,NA,NA,21828076 +OncoKB,PTEN,Oncogenic,NA,LOF,NA,NA,NA,NA,21828076 +OncoKB,PTEN,Oncogenic,NA,LOF,NA,NA,NA,NA,21828076 +OncoKB,PTEN,Likely Neutral,NA,COF,NA,NA,NA,NA,"21828076, 10866302" +OncoKB,PTEN,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,10866302 +OncoKB,PTEN,Oncogenic,NA,LOF,NA,NA,NA,NA,"21828076, 25527629" +OncoKB,PTEN,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,26166433 +OncoKB,PTEN,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,10866302 +OncoKB,PTEN,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,10866302 +OncoKB,PTEN,Oncogenic,NA,LOF,NA,NA,NA,NA,"12844284, 9697695, 12370746, 21430697" +OncoKB,PTEN,Oncogenic,NA,LOF,NA,NA,NA,NA,21828076 +OncoKB,PTEN,Oncogenic,NA,LOF,NA,NA,NA,NA,21828076 +OncoKB,PTEN,Oncogenic,NA,LOF,NA,NA,NA,NA,21828076 +OncoKB,PTEN,Likely Neutral,NA,COF,NA,NA,NA,NA,19329485 +OncoKB,PTEN,Oncogenic,NA,LOF,NA,NA,NA,NA,19329485 +OncoKB,PTEN,Oncogenic,NA,LOF,NA,NA,NA,NA,21828076 +OncoKB,PTEN,Oncogenic,NA,LOF,NA,NA,NA,NA,21828076 +OncoKB,PTEN,Oncogenic,NA,LOF,NA,NA,NA,NA,21828076 +OncoKB,PTEN,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,23039341 +OncoKB,PTEN,Oncogenic,NA,LOF,NA,NA,NA,NA,"11051241, 10866302" +OncoKB,PTEN,Oncogenic,NA,LOF,NA,NA,NA,NA,"9467011, 25527629, 10866302" +OncoKB,BCOR,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"26847029, 10582652, 2212066" +OncoKB,BCOR,Oncogenic,NA,Likely SOF,NA,NA,NA,NA,22387997 +OncoKB,BCOR,Oncogenic,NA,Likely SOF,NA,NA,NA,NA,20807888 +OncoKB,BCOR,Oncogenic,NA,Likely SOF,NA,NA,NA,NA,23580382 +OncoKB,BCOR,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"26847029, 25550361, 22237022, 22012066, 24047651" +OncoKB,BCOR,Likely Oncogenic,NA,Likely SOF,NA,NA,NA,NA,24515802 +OncoKB,RNF43,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"23847203, 23096461, 25344691" +OncoKB,CIC,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"22072439, 25007147, 28188754" +OncoKB,CIC,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"22072542, 25193860" +OncoKB,CIC,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"22072542, 25193860" +OncoKB,CIC,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"22072542, 22588899, 21817013, 24117486, 24086756" +OncoKB,CIC,Oncogenic,NA,SOF,NA,NA,NA,NA,"22072439, 16717057" +OncoKB,INPP4B,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"25883023, 25428846, 19647222, 21127264" +OncoKB,INPP4B,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"25428846, 19647222, 21127264" +OncoKB,STAT3,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"22751495, 17881745, 17676033, 18602572, 26619011" +OncoKB,STAT3,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,25586472 +OncoKB,STAT3,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"22751495, 17881745, 17676033, 18602572, 26619011" +OncoKB,STAT3,Oncogenic,NA,GOF,NA,NA,NA,NA,"25586472, 25873174, 22591296" +OncoKB,STAT3,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"22751495, 17881745, 17676033, 18602572, 26619011" +OncoKB,STAT3,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,"25586472, 25709890" +OncoKB,STAT3,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,22591296 +OncoKB,STAT3,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,26419508 +OncoKB,WHSC1L1,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,"18757432, 24874471, 21664949" +OncoKB,PRDM1,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,21156281 +OncoKB,PRDM1,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,21156281 +OncoKB,PRDM1,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"20651244, 27568520, 16424392, 21156281, 16492805" +OncoKB,PRDM1,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,21156281 +OncoKB,PRDM1,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,21156281 +OncoKB,PRDM1,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"27568520, 16424392, 21156281, 16492805" +OncoKB,JAK1,Oncogenic,NA,GOF,NA,NA,NA,NA,"20868368, 19139102, 21393331" +OncoKB,JAK1,Oncogenic,NA,GOF,NA,NA,NA,NA,19139102 +OncoKB,JAK1,Oncogenic,NA,GOF,NA,NA,NA,NA,21393331 +OncoKB,JAK1,Oncogenic,NA,GOF,NA,NA,NA,NA,21393331 +OncoKB,JAK1,Oncogenic,NA,GOF,NA,NA,NA,NA,18362171 +OncoKB,JAK1,Oncogenic,NA,GOF,NA,NA,NA,NA,23788652 +OncoKB,JAK1,Oncogenic,NA,GOF,NA,NA,NA,NA,20868368 +OncoKB,JAK1,Oncogenic,NA,GOF,NA,NA,NA,NA,"24825865, 23788652" +OncoKB,JAK1,Oncogenic,NA,GOF,NA,NA,NA,NA,21393331 +OncoKB,JAK1,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,24735922 +OncoKB,JAK1,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,24154688 +OncoKB,JAK1,Oncogenic,NA,GOF,NA,NA,NA,NA,20868368 +OncoKB,JAK1,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,16474838 +OncoKB,JAK1,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,21551237 +OncoKB,JAK1,Oncogenic,NA,GOF,NA,NA,NA,NA,18362171 +OncoKB,JAK1,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,25873174 +OncoKB,JAK1,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,21551237 +OncoKB,JAK1,Oncogenic,NA,GOF,NA,NA,NA,NA,"20868368, 25873174, 23788652" +OncoKB,JAK1,Oncogenic,NA,GOF,NA,NA,NA,NA,21393331 +OncoKB,JAK1,Oncogenic,NA,GOF,NA,NA,NA,NA,19470474 +OncoKB,JAK2,Oncogenic,NA,GOF,NA,NA,NA,NA,"12351625, 15793561, 21533163, 19543316" +OncoKB,JAK2,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,26419724 +OncoKB,JAK2,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,26419724 +OncoKB,JAK2,Oncogenic,NA,GOF,NA,NA,NA,NA,"20585391, 17267906, 21362419" +OncoKB,JAK2,Oncogenic,NA,GOF,NA,NA,NA,NA,22960131 +OncoKB,JAK2,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"25515960, 25951811" +OncoKB,JAK2,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,26419724 +OncoKB,JAK2,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,26419724 +OncoKB,JAK2,Oncogenic,NA,GOF,NA,NA,NA,NA,"22733019, 10706877, 9360930, 15676212, 10845925" +OncoKB,JAK2,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"25207766, 24913195" +OncoKB,JAK2,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,26419724 +OncoKB,JAK2,Oncogenic,NA,GOF,NA,NA,NA,NA,"25207766, 25515960" +OncoKB,JAK2,Oncogenic,NA,GOF,NA,NA,NA,NA,20628145 +OncoKB,JAK2,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,26419724 +OncoKB,JAK2,Oncogenic,NA,GOF,NA,NA,NA,NA,"18805579, 23748007, 23452118" +OncoKB,JAK2,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,26419724 +OncoKB,JAK2,Oncogenic,NA,GOF,NA,NA,NA,NA,25207766 +OncoKB,JAK2,Oncogenic,NA,GOF,NA,NA,NA,NA,17267906 +OncoKB,JAK2,Oncogenic,NA,GOF,NA,NA,NA,NA,"18805579, 20585391, 23748007, 23452118" +OncoKB,JAK2,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,26419724 +OncoKB,JAK2,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,26419724 +OncoKB,JAK2,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,26419724 +OncoKB,JAK2,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,26419724 +OncoKB,JAK2,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,26419724 +OncoKB,JAK2,Oncogenic,NA,GOF,NA,NA,NA,NA,17267906 +OncoKB,JAK2,Oncogenic,NA,GOF,NA,NA,NA,NA,"25664618, 22549126, 22384256, 25789185, 23904814, 18537978, 16001431, 24913195, 18503828" +OncoKB,JAK2,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"21325169, 18618714" +OncoKB,JAK2,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,20182460 +OncoKB,JAK2,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,26419724 +OncoKB,JAK2,Oncogenic,NA,GOF,NA,NA,NA,NA,17267906 +OncoKB,JAK2,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,26419724 +OncoKB,JAK2,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,26419724 +OncoKB,JAK2,Oncogenic,NA,GOF,NA,NA,NA,NA,"18805579, 23748007, 23452118" +OncoKB,JAK2,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,26419724 +OncoKB,JAK2,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,26419724 +OncoKB,JAK2,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,"16034466, 21325169, 23372669, 15805263, 16424865, 24913195" +OncoKB,JAK2,Oncogenic,NA,GOF,NA,NA,NA,NA,"20585391, 16804112, 19543316, 21362419" +OncoKB,AURKA,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,"12881723, 12208850" +OncoKB,AURKA,Likely Neutral,NA,LOF,NA,NA,NA,NA,"12237287, 25395580" +OncoKB,AURKA,Oncogenic,NA,GOF,NA,NA,NA,NA,"9606188, 9771714, 10914715" +OncoKB,STK11,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"16582077, 21532627, 1627113, 19892943" +OncoKB,STK11,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,9837816 +OncoKB,STK11,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,"9837816, 15987703" +OncoKB,STK11,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"24652667, 21516316, 19340305, 19892943, 25079552" +OncoKB,STK11,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,25960268 +OncoKB,STK11,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,26917230 +OncoKB,STK11,Likely Neutral,NA,COF,NA,NA,NA,NA,"15800014, 10676634" +OncoKB,STK11,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,"9887330, 14668798, 10430928, 9605748" +OncoKB,STK11,Oncogenic,NA,LOF,NA,NA,NA,NA,"9837816, 12552571" +OncoKB,STK11,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,"15800014, 14668798" +OncoKB,STK11,Oncogenic,NA,LOF,NA,NA,NA,NA,16407837 +OncoKB,STK11,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,14668798 +OncoKB,STK11,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,"9837816, 15987703" +OncoKB,STK11,Oncogenic,NA,LOF,NA,NA,NA,NA,12552571 +OncoKB,STK11,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,"9837816, 15987703" +OncoKB,JUN,Oncogenic,NA,GOF,NA,NA,NA,NA,"19449367, 17418412" +OncoKB,PTPN11,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,15834506 +OncoKB,PTPN11,Oncogenic,NA,GOF,NA,NA,NA,NA,"15834506, 12717436" +OncoKB,PTPN11,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,15604238 +OncoKB,PTPN11,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,24935154 +OncoKB,PTPN11,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,24891296 +OncoKB,PTPN11,Oncogenic,NA,GOF,NA,NA,NA,NA,18286234 +OncoKB,PTPN11,Oncogenic,NA,GOF,NA,NA,NA,NA,"15834506, 12717436" +OncoKB,PTPN11,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,24935154 +OncoKB,PTPN11,Likely Neutral,NA,Likely SOF,NA,NA,NA,NA,25823821 +OncoKB,PTPN11,Oncogenic,NA,GOF,NA,NA,NA,NA,15834506 +OncoKB,PTPN11,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"17053061, 24891296" +OncoKB,PTPN11,Oncogenic,NA,LOF,NA,NA,NA,NA,22869052 +OncoKB,PTPN11,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"25359717, 21803945, 22058153" +OncoKB,PTPN11,Oncogenic,NA,GOF,NA,NA,NA,NA,15834506 +OncoKB,PTPN11,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,16358218 +OncoKB,PTPN11,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,15604238 +OncoKB,PTPN11,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,15834506 +OncoKB,PTPN11,Oncogenic,NA,GOF,NA,NA,NA,NA,"14974085, 15834506" +OncoKB,PTPN11,Oncogenic,NA,GOF,NA,NA,NA,NA,"15604238, 18286234" +OncoKB,PTPN11,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"15604238, 12717436" +OncoKB,PTPN11,Oncogenic,NA,GOF,NA,NA,NA,NA,"15834506, 12717436" +OncoKB,PTPN11,Oncogenic,NA,GOF,NA,NA,NA,NA,15834506 +OncoKB,PTPN11,Oncogenic,NA,GOF,NA,NA,NA,NA,15834506 +OncoKB,PTPN11,Oncogenic,NA,GOF,NA,NA,NA,NA,14974085 +OncoKB,PTPN11,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,15834506 +OncoKB,PTPN11,Oncogenic,NA,GOF,NA,NA,NA,NA,15834506 +OncoKB,PTPN11,Oncogenic,NA,LOF,NA,NA,NA,NA,"26742426, 16358218, 25288766" +OncoKB,PTPN11,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,15834506 +OncoKB,PTPN11,Oncogenic,NA,GOF,NA,NA,NA,NA,"14974085, 15834506, 12717436" +OncoKB,NF1,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,"8052307, 19573811, 24576830, 9003501, 12509763, 8563751, 7542586" +OncoKB,NF1,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"8052307, 26345759, 19573811, 8563751, 23913538, 7542586, 7655472, 10862084, 24576830, 23047742, 10543400, 12509763, 14722914" +OncoKB,NF1,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,"8052307, 19573811, 24576830, 12509763, 8563751, 22807134, 7542586" +OncoKB,NF1,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,"8052307, 19573811, 24576830, 12509763, 8563751, 22807134, 7542586, 22108604" +OncoKB,NF1,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,"8052307, 19573811, 24576830, 12509763, 8563751, 22807134, 7542586" +OncoKB,NF1,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,"8052307, 19573811, 24576830, 12509763, 8563751, 22807134, 7542586" +OncoKB,NF1,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,"23460398, 8052307, 19573811, 24576830, 12509763, 8563751, 19767589, 7542586, 20513137" +OncoKB,NF1,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,"8052307, 19573811, 24576830, 12509763, 8563751, 22807134, 7542586" +OncoKB,NF1,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,"8052307, 19573811, 24576830, 12509763, 8563751, 22807134, 7542586" +OncoKB,NF1,Oncogenic,NA,LOF,NA,NA,NA,NA,"9302992, 9219684, 9668168" +OncoKB,NF1,Oncogenic,NA,LOF,NA,NA,NA,NA,11258625 +OncoKB,NF1,Oncogenic,NA,LOF,NA,NA,NA,NA,"8052307, 19573811, 24576830, 12509763, 8563751, 1568247, 7542586" +OncoKB,NF1,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,23288408 +OncoKB,NF1,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,"8052307, 19573811, 24576830, 12509763, 8563751, 22807134, 7542586" +OncoKB,NF1,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,"8052307, 19573811, 24576830, 12509763, 8563751, 22807134, 7542586" +OncoKB,NF1,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,"8052307, 19573811, 24576830, 12509763, 8563751, 22807134, 7542586" +OncoKB,NF1,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,"8052307, 19573811, 24576830, 12509763, 8563751, 22807134, 7542586" +OncoKB,FOXL2,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,21623383 +OncoKB,FOXL2,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,"24342437, 24817949, 23372819" +OncoKB,PTPRD,Oncogenic,NA,LOF,NA,NA,NA,NA,"19478061, 19074898, 26267899" +OncoKB,PTPRD,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"19074898, 25113440, 8393854" +OncoKB,PTPRD,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"19478061, 26267899" +OncoKB,PTPRD,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"19478061, 25113440" +OncoKB,PTPRD,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,19074898 +OncoKB,PTPRD,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,19478061 +OncoKB,BRCA1,Likely Neutral,NA,COF,NA,NA,NA,NA,20516115 +OncoKB,BRCA1,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,"20103620, 22034435, 23161852, 16403807" +OncoKB,BRCA1,Likely Neutral,NA,COF,NA,NA,NA,NA,23867111 +OncoKB,BRCA1,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,20516115 +OncoKB,BRCA1,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,"22034435, 16403807" +OncoKB,BRCA1,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"15004537, 15172985, 20516115" +OncoKB,BRCA1,Likely Neutral,NA,COF,NA,NA,NA,NA,23867111 +OncoKB,BRCA1,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,23161852 +OncoKB,BRCA1,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"15172985, 11573086, 12496477" +OncoKB,BRCA1,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,23867111 +OncoKB,BRCA1,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,"23867111, 23613828" +OncoKB,BRCA1,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,"18680205, 20516115, 17308087" +OncoKB,BRCA1,Oncogenic,NA,LOF,NA,NA,NA,NA,"14729053, 23867111, 27454287, 15569676, 9145676, 14576434" +OncoKB,BRCA1,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,"22034435, 16403807" +OncoKB,BRCA1,Likely Neutral,NA,COF,NA,NA,NA,NA,23867111 +OncoKB,BRCA1,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,"15172985, 23867111, 9799248, 20516115" +OncoKB,BRCA1,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,"15172985, 10811118, 20516115" +OncoKB,BRCA1,Oncogenic,NA,LOF,NA,NA,NA,NA,"15004537, 14729053, 10811118, 12427738, 7545954, 8751436, 16101277, 11573086, 15689452, 15569676, 8942979, 10635334, 23161852, 15133502, 7939630, 15172985, 20516115, 21922593, 9159158" +OncoKB,BRCA1,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,"15004537, 15172985, 9796975, 15689452, 20516115" +OncoKB,BRCA1,Likely Neutral,NA,COF,NA,NA,NA,NA,23867111 +OncoKB,BRCA1,Likely Neutral,NA,COF,NA,NA,NA,NA,"23867111, 20516115" +OncoKB,BRCA1,Likely Neutral,NA,COF,NA,NA,NA,NA,23867111 +OncoKB,BRCA1,Likely Neutral,NA,COF,NA,NA,NA,NA,23867111 +OncoKB,BRCA1,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,20516115 +OncoKB,BRCA1,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,23161852 +OncoKB,BRCA1,Likely Neutral,NA,COF,NA,NA,NA,NA,20516115 +OncoKB,BRCA1,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,18680205 +OncoKB,BRCA1,Likely Neutral,NA,COF,NA,NA,NA,NA,"20103620, 23161852" +OncoKB,BRCA1,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,20516115 +OncoKB,BRCA1,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,21922593 +OncoKB,BRCA1,Likely Neutral,NA,COF,NA,NA,NA,NA,20516115 +OncoKB,BRCA1,Likely Neutral,NA,COF,NA,NA,NA,NA,20516115 +OncoKB,BRCA1,Likely Neutral,NA,COF,NA,NA,NA,NA,20516115 +OncoKB,BRCA1,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,"15172985, 20516115, 11157798" +OncoKB,BRCA1,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,"22034435, 16403807" +OncoKB,BRCA1,Likely Neutral,NA,COF,NA,NA,NA,NA,"15004537, 15172985, 23867111, 15689452, 20516115" +OncoKB,BRCA1,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,15004537 +OncoKB,BRCA1,Likely Neutral,NA,COF,NA,NA,NA,NA,17308087 +OncoKB,BRCA1,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,"15172985, 23867111, 12496477" +OncoKB,BRCA1,Likely Neutral,NA,COF,NA,NA,NA,NA,9159158 +OncoKB,BRCA1,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"15172985, 10811118" +OncoKB,BRCA1,Likely Neutral,NA,COF,NA,NA,NA,NA,23867111 +OncoKB,BRCA1,Likely Neutral,NA,COF,NA,NA,NA,NA,23161852 +OncoKB,BRCA1,Likely Neutral,NA,COF,NA,NA,NA,NA,23161852 +OncoKB,BRCA1,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,"15172985, 23867111, 9799248, 8968102, 15689452, 20516115" +OncoKB,BRCA1,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"15004537, 15172985, 10811118" +OncoKB,BRCA1,Oncogenic,NA,LOF,NA,NA,NA,NA,"15172985, 23867111, 11573086, 12496476, 20516115, 11157798, 7939630" +OncoKB,BRCA1,Likely Neutral,NA,COF,NA,NA,NA,NA,23867111 +OncoKB,BRCA1,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,20516115 +OncoKB,BRCA1,Likely Neutral,NA,COF,NA,NA,NA,NA,15689452 +OncoKB,BRCA1,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,"18680205, 23161852" +OncoKB,BRCA1,Likely Neutral,NA,COF,NA,NA,NA,NA,"15004537, 15172985, 10811118, 20516115, 17308087" +OncoKB,BRCA1,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,"15172985, 10196379" +OncoKB,BRCA1,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,"22034435, 16403807" +OncoKB,BRCA1,Likely Neutral,NA,COF,NA,NA,NA,NA,17308087 +OncoKB,BRCA1,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,"22034435, 16403807" +OncoKB,BRCA1,Oncogenic,NA,LOF,NA,NA,NA,NA,"20103620, 22034435, 23161852, 21922593, 16403807" +OncoKB,BRCA1,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,20516115 +OncoKB,BRCA1,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,20516115 +OncoKB,BRCA1,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,20516115 +OncoKB,BRCA1,Likely Neutral,NA,COF,NA,NA,NA,NA,23613828 +OncoKB,BRCA1,Likely Neutral,NA,COF,NA,NA,NA,NA,23867111 +OncoKB,BRCA1,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,"22034435, 16403807" +OncoKB,BRCA1,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"23867111, 19369211, 15689452, 16793542, 15770685" +OncoKB,BRCA1,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,"15172985, 20516115, 11157798" +OncoKB,BRCA1,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"15172985, 9799248, 20516115" +OncoKB,BRCA1,Likely Neutral,NA,COF,NA,NA,NA,NA,23867111 +OncoKB,BRCA1,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,"22034435, 16403807" +OncoKB,BRCA1,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,20516115 +OncoKB,BRCA1,Likely Neutral,NA,COF,NA,NA,NA,NA,"20103620, 23161852, 16403807" +OncoKB,BRCA1,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,"20103620, 22034435, 23161852, 16403807" +OncoKB,BRCA1,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,15172985 +OncoKB,BRCA1,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,"20103620, 23867111, 22034435, 10635334, 23161852, 16403807" +OncoKB,BRCA1,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,"20103620, 11385711, 23161852" +OncoKB,BRCA1,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,"22034435, 16403807" +OncoKB,BRCA1,Likely Neutral,NA,COF,NA,NA,NA,NA,"15172985, 23867111, 15689452, 15923272, 20516115" +OncoKB,BRCA1,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"15172985, 10811118" +OncoKB,BRCA1,Likely Neutral,NA,COF,NA,NA,NA,NA,"18036263, 18497862" +OncoKB,BRCA1,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,23867111 +OncoKB,BRCA1,Likely Neutral,NA,COF,NA,NA,NA,NA,23867111 +OncoKB,BRCA1,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,"22034435, 16403807" +OncoKB,BRCA1,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,"22034435, 16403807" +OncoKB,BRCA1,Likely Neutral,NA,COF,NA,NA,NA,NA,"15172985, 20516115" +OncoKB,BRCA1,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,23613828 +OncoKB,BRCA1,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"15172985, 20516115" +OncoKB,BRCA1,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"15004537, 15172985, 20516115" +OncoKB,BRCA1,Likely Neutral,NA,COF,NA,NA,NA,NA,23867111 +OncoKB,BRCA1,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,23867111 +OncoKB,BRCA1,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,"14729053, 20103620, 23867111, 22034435, 15569676, 23161852, 16403807" +OncoKB,BRCA1,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,18992264 +OncoKB,BRCA1,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,"20103620, 23161852" +OncoKB,BRCA1,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,"22034435, 16403807" +OncoKB,BRCA1,Likely Neutral,NA,COF,NA,NA,NA,NA,20516115 +OncoKB,BRCA1,Likely Neutral,NA,COF,NA,NA,NA,NA,23867111 +OncoKB,BRCA1,Likely Neutral,NA,COF,NA,NA,NA,NA,"15172985, 12142080, 20516115" +OncoKB,BRCA1,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,20516115 +OncoKB,BRCA1,Likely Neutral,NA,COF,NA,NA,NA,NA,23842040 +OncoKB,BRCA1,Likely Neutral,NA,COF,NA,NA,NA,NA,15689452 +OncoKB,BRCA1,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,"15172985, 9809041" +OncoKB,BRCA1,Likely Neutral,NA,COF,NA,NA,NA,NA,23867111 +OncoKB,BRCA1,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,15004537 +OncoKB,BRCA1,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"15172985, 20516115" +OncoKB,BRCA1,Likely Neutral,NA,COF,NA,NA,NA,NA,23161852 +OncoKB,BRCA1,Likely Neutral,NA,COF,NA,NA,NA,NA,"15172985, 20516115" +OncoKB,BRCA1,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,20516115 +OncoKB,BRCA1,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"15172985, 20516115" +OncoKB,BRCA1,Likely Neutral,NA,COF,NA,NA,NA,NA,23867111 +OncoKB,BRCA1,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"15172985, 12496477" +OncoKB,BRCA1,Likely Neutral,NA,COF,NA,NA,NA,NA,23867111 +OncoKB,BRCA1,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,"22034435, 16403807" +OncoKB,BRCA1,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,20516115 +OncoKB,BRCA1,Likely Neutral,NA,COF,NA,NA,NA,NA,20516115 +OncoKB,BRCA1,Likely Neutral,NA,COF,NA,NA,NA,NA,"15172985, 20516115" +OncoKB,BRCA1,Likely Neutral,NA,COF,NA,NA,NA,NA,23161852 +OncoKB,BRCA1,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,20516115 +OncoKB,BRCA1,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,"22034435, 16403807" +OncoKB,BRCA1,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,"22034435, 16403807" +OncoKB,BRCA1,Likely Neutral,NA,COF,NA,NA,NA,NA,20516115 +OncoKB,BRCA1,Likely Neutral,NA,COF,NA,NA,NA,NA,23867111 +OncoKB,BRCA1,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,"15172985, 15689452, 20516115" +OncoKB,BRCA1,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,"22034435, 16403807" +OncoKB,BRCA1,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,"15004537, 15172985, 23867111, 15350310, 20516115, 17308087" +OncoKB,BRCA1,Likely Neutral,NA,COF,NA,NA,NA,NA,"15172985, 20516115" +OncoKB,BRCA1,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,"23867111, 20516115, 17308087" +OncoKB,BRCA1,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,"15172985, 9544765" +OncoKB,BRCA1,Likely Neutral,NA,COF,NA,NA,NA,NA,20516115 +OncoKB,BRCA1,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"12483515, 11358863, 20608970, 12947386" +OncoKB,BRCA1,Likely Neutral,NA,COF,NA,NA,NA,NA,23867111 +OncoKB,BRCA1,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"15172985, 10811118, 11573086" +OncoKB,BRCA1,Oncogenic,NA,LOF,NA,NA,NA,NA,"20516115, 17308087, 9159158" +OncoKB,BRCA1,Likely Neutral,NA,COF,NA,NA,NA,NA,18992264 +OncoKB,BRCA1,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,20516115 +OncoKB,BRCA1,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,"20103620, 22034435, 23161852, 16403807" +OncoKB,BRCA1,Likely Neutral,NA,COF,NA,NA,NA,NA,15569676 +OncoKB,BRCA1,Likely Neutral,NA,COF,NA,NA,NA,NA,20516115 +OncoKB,BRCA1,Likely Neutral,NA,COF,NA,NA,NA,NA,9159158 +OncoKB,BRCA1,Likely Neutral,NA,COF,NA,NA,NA,NA,23867111 +OncoKB,BRCA1,Likely Neutral,NA,COF,NA,NA,NA,NA,"15172985, 17161371, 20516115" +OncoKB,BRCA1,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,"22034435, 16403807" +OncoKB,BRCA1,Oncogenic,NA,LOF,NA,NA,NA,NA,"22034435, 21922593, 16403807" +OncoKB,BRCA1,Likely Neutral,NA,COF,NA,NA,NA,NA,23867111 +OncoKB,BRCA1,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"23867111, 20516115" +OncoKB,BRCA1,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"15172985, 11573086, 12496477" +OncoKB,BRCA1,Likely Neutral,NA,COF,NA,NA,NA,NA,23867111 +OncoKB,BRCA1,Likely Neutral,NA,COF,NA,NA,NA,NA,23867111 +OncoKB,BRCA1,Likely Neutral,NA,COF,NA,NA,NA,NA,23161852 +OncoKB,BRCA1,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,"23867111, 19369211, 16793542, 15770685" +OncoKB,BRCA1,Likely Neutral,NA,COF,NA,NA,NA,NA,23867111 +OncoKB,BRCA1,Likely Neutral,NA,COF,NA,NA,NA,NA,23613828 +OncoKB,BRCA1,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"15172985, 12496477" +OncoKB,BRCA1,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"15172985, 9799248, 20516115" +OncoKB,BRCA1,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,"15172985, 23867111, 20516115, 17308087" +OncoKB,BRCA1,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,15172985 +OncoKB,BRCA1,Likely Neutral,NA,COF,NA,NA,NA,NA,23867111 +OncoKB,BRCA1,Likely Neutral,NA,COF,NA,NA,NA,NA,23867111 +OncoKB,BRCA1,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,20516115 +OncoKB,BRCA1,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,"22034435, 16403807" +OncoKB,BRCA1,Likely Neutral,NA,COF,NA,NA,NA,NA,"18992264, 20516115" +OncoKB,BRCA1,Likely Neutral,NA,COF,NA,NA,NA,NA,"15172985, 10811118, 17161371, 20516115, 11157798" +OncoKB,BRCA1,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"12483515, 18501021, 27452521, 12670888, 9354803" +OncoKB,BRCA1,Likely Neutral,NA,COF,NA,NA,NA,NA,23867111 +OncoKB,BRCA1,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,15689452 +OncoKB,BRCA1,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,"23867111, 19369211, 16793542, 15770685" +OncoKB,BRCA1,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,"22034435, 16403807" +OncoKB,BRCA1,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,"15004537, 15172985, 23867111, 20516115, 17308087" +OncoKB,BRCA1,Likely Neutral,NA,COF,NA,NA,NA,NA,"23867111, 20516115, 17308087" +OncoKB,BRCA1,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,23613828 +OncoKB,BRCA1,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,"15172985, 20516115, 11157798" +OncoKB,BRCA1,Likely Neutral,NA,COF,NA,NA,NA,NA,20516115 +OncoKB,BRCA1,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,17308087 +OncoKB,BRCA1,Likely Neutral,NA,COF,NA,NA,NA,NA,"15172985, 20516115, 11157798" +OncoKB,BRCA1,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,"20103620, 22034435, 23161852, 16403807" +OncoKB,BRCA1,Likely Neutral,NA,COF,NA,NA,NA,NA,23867111 +OncoKB,BRCA1,Likely Neutral,NA,COF,NA,NA,NA,NA,23867111 +OncoKB,BRCA1,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,"22034435, 16403807" +OncoKB,BRCA1,Likely Neutral,NA,COF,NA,NA,NA,NA,20516115 +OncoKB,BRCA1,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"15004537, 15172985, 20516115" +OncoKB,BRCA1,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,"22034435, 16403807" +OncoKB,BRCA1,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"15172985, 11573086, 20516115" +OncoKB,BRCA1,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,"15172985, 20516115, 17308087" +OncoKB,BRCA1,Likely Neutral,NA,COF,NA,NA,NA,NA,23867111 +OncoKB,BRCA1,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,20516115 +OncoKB,BRCA1,Likely Neutral,NA,COF,NA,NA,NA,NA,"23867111, 18680205, 23161852" +OncoKB,BRCA1,Likely Neutral,NA,COF,NA,NA,NA,NA,"9150149, 15172985, 20516115" +OncoKB,BRCA1,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,"23867111, 10635334" +OncoKB,BRCA1,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,23867111 +OncoKB,BRCA1,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,20516115 +OncoKB,BRCA1,Likely Neutral,NA,COF,NA,NA,NA,NA,23613828 +OncoKB,BRCA1,Likely Neutral,NA,COF,NA,NA,NA,NA,"23867111, 17308087" +OncoKB,BRCA1,Likely Neutral,NA,COF,NA,NA,NA,NA,"15172985, 20516115" +OncoKB,BRCA1,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"15172985, 20516115" +OncoKB,BRCA1,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,25416589 +OncoKB,BRCA1,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"15172985, 20516115, 17308087" +OncoKB,BRCA1,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,"22034435, 16403807" +OncoKB,BRCA1,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,"15172985, 23867111, 11573086, 20516115, 11157798" +OncoKB,BRCA1,Likely Neutral,NA,COF,NA,NA,NA,NA,"20103620, 22034435, 23161852, 16403807" +OncoKB,BRCA1,Likely Neutral,NA,COF,NA,NA,NA,NA,23867111 +OncoKB,BRCA1,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,"23867111, 20516115" +OncoKB,BRCA1,Likely Neutral,NA,COF,NA,NA,NA,NA,"23867111, 23161852" +OncoKB,BRCA1,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,"22034435, 16403807" +OncoKB,BRCA1,Likely Neutral,NA,COF,NA,NA,NA,NA,"20516115, 17308087" +OncoKB,BRCA1,Likely Neutral,NA,COF,NA,NA,NA,NA,"23867111, 23161852" +OncoKB,BRCA1,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"15172985, 20516115" +OncoKB,BRCA1,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,"22034435, 16403807" +OncoKB,BRCA1,Likely Neutral,NA,COF,NA,NA,NA,NA,"20103620, 23161852" +OncoKB,BRCA1,Likely Neutral,NA,COF,NA,NA,NA,NA,"15172985, 11573086, 8942979" +OncoKB,BRCA1,Likely Neutral,NA,COF,NA,NA,NA,NA,23867111 +OncoKB,BRCA1,Likely Neutral,NA,COF,NA,NA,NA,NA,"15172985, 20516115" +OncoKB,BRCA1,Likely Neutral,NA,COF,NA,NA,NA,NA,"15172985, 11573086, 20516115" +OncoKB,BRCA1,Likely Neutral,NA,COF,NA,NA,NA,NA,18680205 +OncoKB,BRCA1,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,15172985 +OncoKB,BRCA1,Likely Neutral,NA,COF,NA,NA,NA,NA,"23867111, 17308087" +OncoKB,BRCA1,Oncogenic,NA,LOF,NA,NA,NA,NA,"15172985, 23867111, 8751436, 11573086, 15923272, 8942979, 20516115, 21922593, 11157798, 9159158, 7939630" +OncoKB,BRCA1,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,21922593 +OncoKB,BRCA1,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"15172985, 20516115" +OncoKB,BRCA1,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"15172985, 12496477" +OncoKB,BRCA1,Likely Neutral,NA,COF,NA,NA,NA,NA,"23867111, 23161852" +OncoKB,BRCA1,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"15172985, 10811118" +OncoKB,BRCA1,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,8942979 +OncoKB,BRCA1,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"15172985, 20516115" +OncoKB,BRCA1,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"15172985, 11573086, 8942979" +OncoKB,BRCA1,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,"22034435, 16403807" +OncoKB,BRCA1,Likely Neutral,NA,COF,NA,NA,NA,NA,"20103620, 23867111, 23161852" +OncoKB,BRCA1,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,"15172985, 15689452, 20516115" +OncoKB,BRCA1,Oncogenic,NA,LOF,NA,NA,NA,NA,"20103620, 23867111, 23161852, 21922593" +OncoKB,BRCA1,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,"15004537, 23867111, 20516115, 17308087" +OncoKB,BRCA1,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"15172985, 15689452, 20516115" +OncoKB,BRCA1,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,23867111 +OncoKB,BRCA1,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,"20516115, 17308087" +OncoKB,BRCA1,Oncogenic,NA,LOF,NA,NA,NA,NA,"15004537, 14729053, 8942979, 15569676, 21922593" +OncoKB,BRCA1,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"15172985, 11595708, 20516115" +OncoKB,BRCA1,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"15172985, 12496477" +OncoKB,BRCA1,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,"15172985, 18285836, 11573086, 8942979, 20516115" +OncoKB,BRCA1,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"15172985, 20516115" +OncoKB,BRCA1,Likely Neutral,NA,COF,NA,NA,NA,NA,"15172985, 20516115, 17308087" +OncoKB,BRCA1,Likely Neutral,NA,COF,NA,NA,NA,NA,"15172985, 10196379, 20516115, 11157798" +OncoKB,BRCA1,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,"22034435, 16403807" +OncoKB,BRCA1,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"15172985, 20516115" +OncoKB,BRCA1,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,"22034435, 16403807" +OncoKB,BRCA1,Likely Neutral,NA,COF,NA,NA,NA,NA,23867111 +OncoKB,BRCA1,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,"15172985, 10811118, 20516115" +OncoKB,BRCA1,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,"23842040, 20516115" +OncoKB,BRCA1,Likely Neutral,NA,COF,NA,NA,NA,NA,"15004537, 15172985, 20516115" +OncoKB,BRCA1,Oncogenic,NA,LOF,NA,NA,NA,NA,"14729053, 23867111, 27454287, 27454289, 15569676, 9145676, 14576434" +OncoKB,BRCA1,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,23867111 +OncoKB,BRCA1,Likely Neutral,NA,COF,NA,NA,NA,NA,"15172985, 20516115" +OncoKB,BRCA1,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"15004537, 18992264, 15172985, 12142080, 20516115" +OncoKB,BRCA1,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,"20103620, 23161852" +OncoKB,BRCA1,Likely Neutral,NA,COF,NA,NA,NA,NA,23867111 +OncoKB,BRCA1,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"15172985, 10811118, 11573086" +OncoKB,BRCA1,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,"15004537, 15172985, 9585608, 20516115" +OncoKB,BRCA1,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,"22034435, 16403807" +OncoKB,BRCA1,Likely Neutral,NA,COF,NA,NA,NA,NA,"18680205, 15689452" +OncoKB,BRCA1,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,"22034435, 16403807" +OncoKB,BRCA1,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"15172985, 12496477" +OncoKB,BRCA1,Likely Neutral,NA,COF,NA,NA,NA,NA,23867111 +OncoKB,BRCA1,Likely Neutral,NA,COF,NA,NA,NA,NA,23867111 +OncoKB,BRCA1,Likely Neutral,NA,COF,NA,NA,NA,NA,23613828 +OncoKB,BRCA1,Likely Neutral,NA,COF,NA,NA,NA,NA,20516115 +OncoKB,BRCA1,Likely Neutral,NA,COF,NA,NA,NA,NA,23867111 +OncoKB,BRCA1,Likely Neutral,NA,COF,NA,NA,NA,NA,23867111 +OncoKB,BRCA1,Likely Neutral,NA,COF,NA,NA,NA,NA,"15172985, 20516115, 11157798" +OncoKB,BRCA1,Likely Neutral,NA,COF,NA,NA,NA,NA,20516115 +OncoKB,BRCA1,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,20516115 +OncoKB,BRCA1,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,17308087 +OncoKB,BRCA1,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,"15004537, 15172985, 23867111, 20516115" +OncoKB,BRCA1,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,18493658 +OncoKB,BRCA1,Likely Neutral,NA,COF,NA,NA,NA,NA,20516115 +OncoKB,BRCA1,Likely Neutral,NA,COF,NA,NA,NA,NA,23867111 +OncoKB,BRCA1,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"15172985, 20516115" +OncoKB,BRCA1,Likely Neutral,NA,COF,NA,NA,NA,NA,23867111 +OncoKB,BRCA1,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,"15004537, 15172985, 20516115" +OncoKB,BRCA1,Likely Neutral,NA,COF,NA,NA,NA,NA,"15172985, 20516115" +OncoKB,BRCA1,Likely Neutral,NA,COF,NA,NA,NA,NA,23867111 +OncoKB,BRCA1,Oncogenic,NA,LOF,NA,NA,NA,NA,"14729053, 15172985, 8751436, 15569676, 10635334, 20516115, 21922593, 9159158" +OncoKB,BRCA1,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"12497638, 15172985, 20516115" +OncoKB,BRCA1,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,"22034435, 16403807" +OncoKB,BRCA1,Likely Neutral,NA,COF,NA,NA,NA,NA,15004537 +OncoKB,BRCA1,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,"15172985, 9799248, 10196379, 20516115" +OncoKB,BRCA1,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"15172985, 20516115" +OncoKB,BRCA1,Likely Neutral,NA,COF,NA,NA,NA,NA,"23867111, 15350310, 15689452" +OncoKB,BRCA1,Likely Neutral,NA,COF,NA,NA,NA,NA,23867111 +OncoKB,BRCA1,Likely Neutral,NA,COF,NA,NA,NA,NA,"18992264, 15172985, 23867111, 9326340, 12215251, 9523200, 20516115, 21922593, 9159158" +OncoKB,BRCA1,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,21922593 +OncoKB,BRCA1,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"15172985, 17020472" +OncoKB,BRCA1,Oncogenic,NA,LOF,NA,NA,NA,NA,"23867111, 18680205" +OncoKB,BRCA1,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,"15172985, 10811118, 20516115, 17308087, 11157798" +OncoKB,BRCA1,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,20516115 +OncoKB,BRCA1,Likely Neutral,NA,COF,NA,NA,NA,NA,20516115 +OncoKB,BRCA1,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,"15172985, 23867111, 20516115, 17308087" +OncoKB,BRCA1,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,"15172985, 23867111, 9809041" +OncoKB,BRCA1,Likely Neutral,NA,COF,NA,NA,NA,NA,20516115 +OncoKB,BRCA1,Likely Neutral,NA,COF,NA,NA,NA,NA,23867111 +OncoKB,BRAF,Oncogenic,NA,GOF,NA,NA,NA,NA,"16273091, 22663011, 12068308, 25265492, 24508103, 25287827, 25399551, 15035987" +OncoKB,BRAF,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,19206169 +OncoKB,BRAF,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,"14678966, 20141835, 15035987" +OncoKB,BRAF,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"15150094, 22510884, 15035987, 16439621" +OncoKB,BRAF,Oncogenic,NA,GOF,NA,NA,NA,NA,"26045855, 23833300" +OncoKB,BRAF,Likely Neutral,NA,LOF,NA,NA,NA,NA,22926515 +OncoKB,BRAF,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,"15630448, 21424530" +OncoKB,BRAF,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"22798288, 26643848" +OncoKB,BRAF,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,15046639 +OncoKB,BRAF,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,18060073 +OncoKB,BRAF,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"23833300, 20141835, 16439621" +OncoKB,BRAF,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,26732095 +OncoKB,BRAF,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,15035987 +OncoKB,BRAF,Likely Neutral,NA,COF,NA,NA,NA,NA,19206169 +OncoKB,BRAF,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,15035987 +OncoKB,BRAF,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,26732095 +OncoKB,BRAF,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,"15150094, 15035987" +OncoKB,BRAF,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,"24270325, 26343582" +OncoKB,BRAF,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"23833300, 18794803, 20141835, 16439621" +OncoKB,BRAF,Oncogenic,NA,GOF,NA,NA,NA,NA,26732095 +OncoKB,BRAF,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,28174173 +OncoKB,BRAF,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"16364920, 15046639, 15035987" +OncoKB,BRAF,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,20978199 +OncoKB,BRAF,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,"14678966, 16364920, 15035987" +OncoKB,BRAF,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,16501605 +OncoKB,BRAF,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,26732095 +OncoKB,BRAF,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,16501605 +OncoKB,BRAF,Oncogenic,NA,GOF,NA,NA,NA,NA,"25515853, 24112705, 24283590" +OncoKB,BRAF,Oncogenic,NA,GOF,NA,NA,NA,NA,21190184 +OncoKB,BRAF,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,26343582 +OncoKB,BRAF,Likely Neutral,NA,COF,NA,NA,NA,NA,"15150094, 15035987" +OncoKB,BRAF,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,"22798288, 24583796, 24933606, 26643848, 23248257, 15035987" +OncoKB,BRAF,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,"14678966, 19376813, 15035987, 16439621" +OncoKB,BRAF,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"19376813, 23533272, 15035987, 27025703" +OncoKB,BRAF,Oncogenic,NA,GOF,NA,NA,NA,NA,"23833300, 21190184, 19363522" +OncoKB,BRAF,Likely Neutral,NA,COF,NA,NA,NA,NA,"15150094, 20141835, 15035987" +OncoKB,BRAF,Likely Neutral,NA,COF,NA,NA,NA,NA,"15573099, 20538618" +OncoKB,BRAF,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,"19376813, 16439621" +OncoKB,BRAF,Oncogenic,NA,GOF,NA,NA,NA,NA,"25120313, 19206169" +OncoKB,BRAF,Oncogenic,NA,GOF,NA,NA,NA,NA,"23463675, 16273091, 12068308, 15035987, 25382067" +OncoKB,BRAF,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"22798288, 26643848" +OncoKB,BRAF,Oncogenic,NA,GOF,NA,NA,NA,NA,17297294 +OncoKB,BRAF,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,21478863 +OncoKB,BRAF,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,15035987 +OncoKB,BRAF,Likely Neutral,NA,COF,NA,NA,NA,NA,"15150094, 15035987" +OncoKB,BRAF,Oncogenic,NA,GOF,NA,NA,NA,NA,"25266736, 25985019, 22745804, 24345920" +OncoKB,BRAF,Oncogenic,NA,GOF,NA,NA,NA,NA,15150094 +OncoKB,BRAF,Likely Neutral,NA,COF,NA,NA,NA,NA,"16474404, 16439621" +OncoKB,BRAF,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,22649091 +OncoKB,BRAF,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,23833300 +OncoKB,BRAF,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,"15630448, 24345920" +OncoKB,BRAF,Oncogenic,NA,GOF,NA,NA,NA,NA,22113612 +OncoKB,BRAF,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,22798288 +OncoKB,BRAF,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,"19376813, 16474404, 16439621" +OncoKB,BRAF,Oncogenic,NA,GOF,NA,NA,NA,NA,"23317446, 20551065, 16273091, 12068308, 15035987" +OncoKB,BRAF,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,19200582 +OncoKB,BRAF,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"18974108, 26314551, 15630448, 23817572" +OncoKB,BRAF,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,23817572 +OncoKB,BRAF,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,"26343582, 22798288, 26643848" +OncoKB,BRAF,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,"16474404, 16439621" +OncoKB,BRAF,Oncogenic,NA,GOF,NA,NA,NA,NA,"15150094, 12068308, 15035987" +OncoKB,BRAF,Oncogenic,NA,GOF,NA,NA,NA,NA,"18974108, 23533272, 24345920" +OncoKB,BRAF,Oncogenic,NA,GOF,NA,NA,NA,NA,"16273091, 12068308, 23473613, 15035987, 23490649" +OncoKB,BRAF,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,26732095 +OncoKB,BRAF,Oncogenic,NA,GOF,NA,NA,NA,NA,"26314551, 23890088, 24135138" +OncoKB,BRAF,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"25870796, 23401075" +OncoKB,BRAF,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,"26150740, 24920063, 16096377, 26343582, 26619011" +OncoKB,BRAF,Likely Neutral,NA,COF,NA,NA,NA,NA,"15573099, 20538618" +OncoKB,BRAF,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,19206169 +OncoKB,BRAF,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"25985019, 22745804, 15630448, 26324360" +OncoKB,BRAF,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"18974108, 26314551, 25985019, 23890088, 22745804, 15630448, 26324360, 21424530, 24345920" +OncoKB,BRAF,Oncogenic,NA,GOF,NA,NA,NA,NA,16501605 +OncoKB,BRAF,Likely Neutral,NA,LOF,NA,NA,NA,NA,"26619011, 22926515" +OncoKB,BRAF,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,"20735442, 16273091, 12068308, 26287849, 15035987" +OncoKB,BRAF,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"24920063, 24035431" +OncoKB,BRAF,Oncogenic,NA,GOF,NA,NA,NA,NA,15630448 +OncoKB,BRAF,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,16474404 +OncoKB,BRAF,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,26732095 +OncoKB,BRAF,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,19206169 +OncoKB,BRAF,Oncogenic,NA,GOF,NA,NA,NA,NA,25348715 +OncoKB,BRAF,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"19376813, 16439621" +OncoKB,BRAF,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,"15630448, 24345920" +OncoKB,BRAF,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,"17603482, 16474404" +OncoKB,BRAF,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"26732095, 18060073" +OncoKB,BRAF,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,"17724477, 15035987" +OncoKB,BRAF,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,26732095 +OncoKB,BRAF,Likely Neutral,NA,LOF,NA,NA,NA,NA,20179705 +OncoKB,BRAF,Oncogenic,NA,GOF,NA,NA,NA,NA,22752848 +OncoKB,BRAF,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"19474002, 26084293, 19276360, 15035987" +OncoKB,BRAF,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,15035987 +OncoKB,BRAF,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,23658559 +OncoKB,BRAF,Likely Neutral,NA,COF,NA,NA,NA,NA,17603482 +OncoKB,BRAF,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,16474404 +OncoKB,BRAF,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"27799065, 23533272, 15035987" +OncoKB,BRAF,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,"16474404, 16439621" +OncoKB,BRAF,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,25155755 +OncoKB,BRAF,Likely Oncogenic,NA,GOF,NA,NA,NA,NA, +OncoKB,BRAF,Oncogenic,NA,GOF,NA,NA,NA,NA,"15467732, 24055054, 25618114, 22395615, 21098728" +OncoKB,BRAF,Oncogenic,NA,GOF,NA,NA,NA,NA,"23833300, 12068308, 22510884, 15035987, 22773810, 16439621" +OncoKB,BRAF,Oncogenic,NA,GOF,NA,NA,NA,NA,"20179705, 16273091, 23153539, 12068308, 15035987" +OncoKB,BRAF,Likely Neutral,NA,COF,NA,NA,NA,NA,"15573099, 20538618" +OncoKB,BRAF,Oncogenic,NA,GOF,NA,NA,NA,NA,"26343582, 12068308, 26643848, 15035987" +OncoKB,BRAF,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,"16364920, 15035987, 24446311" +OncoKB,BRAF,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,"22649091, 24202393, 16364920, 15035987, 16439621" +OncoKB,BRCA2,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,18824701 +OncoKB,BRCA2,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,18824701 +OncoKB,BRCA2,Likely Neutral,NA,COF,NA,NA,NA,NA,18451181 +OncoKB,BRCA2,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,17924331 +OncoKB,BRCA2,Likely Neutral,NA,COF,NA,NA,NA,NA,"17924331, 18451181" +OncoKB,BRCA2,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,17924331 +OncoKB,BRCA2,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,18375895 +OncoKB,BRCA2,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,18375895 +OncoKB,BRCA2,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,17924331 +OncoKB,BRCA2,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,17924331 +OncoKB,BRCA2,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,18824701 +OncoKB,BRCA2,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,18451181 +OncoKB,BRCA2,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,17924331 +OncoKB,BRCA2,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,18824701 +OncoKB,BRCA2,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,18824701 +OncoKB,BRCA2,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,17924331 +OncoKB,BRCA2,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,18375895 +OncoKB,BRCA2,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,18824701 +OncoKB,BRCA2,Likely Neutral,NA,COF,NA,NA,NA,NA,18451181 +OncoKB,BRCA2,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,18824701 +OncoKB,BRCA2,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,18375895 +OncoKB,BRCA2,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,"17924331, 18451181, 12624152" +OncoKB,BRCA2,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,17924331 +OncoKB,BRCA2,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,18824701 +OncoKB,BRCA2,Likely Neutral,NA,COF,NA,NA,NA,NA,"16489001, 18824701" +OncoKB,BRCA2,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,17924331 +OncoKB,BRCA2,Likely Neutral,NA,COF,NA,NA,NA,NA,18451181 +OncoKB,BRCA2,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,22962691 +OncoKB,BRCA2,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,18824701 +OncoKB,BRCA2,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"17924331, 16489001, 18451181" +OncoKB,BRCA2,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,16489001 +OncoKB,BRCA2,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"17924331, 18451181" +OncoKB,BRCA2,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,17924331 +OncoKB,BRCA2,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,18451181 +OncoKB,BRCA2,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,18375895 +OncoKB,BRCA2,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,17924331 +OncoKB,BRCA2,Likely Neutral,NA,COF,NA,NA,NA,NA,"17924331, 18824701" +OncoKB,BRCA2,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,18824701 +OncoKB,BRCA2,Likely Neutral,NA,COF,NA,NA,NA,NA,18451181 +OncoKB,BRCA2,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,17924331 +OncoKB,BRCA2,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,22962691 +OncoKB,BRCA2,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,17924331 +OncoKB,BRCA2,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,17924331 +OncoKB,BRCA2,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,17924331 +OncoKB,BRCA2,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,17924331 +OncoKB,BRCA2,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,18824701 +OncoKB,BRCA2,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,17924331 +OncoKB,BRCA2,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,18824701 +OncoKB,BRCA2,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,16489001 +OncoKB,BRCA2,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,17924331 +OncoKB,BRCA2,Likely Neutral,NA,COF,NA,NA,NA,NA,"17924331, 18375895" +OncoKB,BRCA2,Likely Neutral,NA,COF,NA,NA,NA,NA,"16489001, 18451181, 18824701, 15290653" +OncoKB,BRCA2,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,22962691 +OncoKB,BRCA2,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,17924331 +OncoKB,BRCA2,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,22962691 +OncoKB,BRCA2,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,16489001 +OncoKB,BRCA2,Likely Neutral,NA,COF,NA,NA,NA,NA,"17924331, 18824701" +OncoKB,BRCA2,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"19179552, 23451180, 22962691" +OncoKB,BRCA2,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,16489001 +OncoKB,BRCA2,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,18451181 +OncoKB,BRCA2,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,22962691 +OncoKB,BRCA2,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,17924331 +OncoKB,BRCA2,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"18424508, 22505045" +OncoKB,BRCA2,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,18824701 +OncoKB,BRCA2,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,18824701 +OncoKB,BRCA2,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,18824701 +OncoKB,BRCA2,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,17924331 +OncoKB,BRCA2,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,17924331 +OncoKB,BRCA2,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,23108138 +OncoKB,BRCA2,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,17924331 +OncoKB,BRCA2,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,17924331 +OncoKB,BRCA2,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"17924331, 18451181" +OncoKB,BRCA2,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,17924331 +OncoKB,BRCA2,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,18824701 +OncoKB,BRCA2,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,18824701 +OncoKB,BRCA2,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,18824701 +OncoKB,BRCA2,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"17924331, 18451181" +OncoKB,BRCA2,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,"18824701, 15290653" +OncoKB,BRCA2,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,17924331 +OncoKB,BRCA2,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,18824701 +OncoKB,BRCA2,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,17924331 +OncoKB,BRCA2,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"17924331, 18451181" +OncoKB,BRCA2,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"16489001, 18451181, 15290653" +OncoKB,BRCA2,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,17924331 +OncoKB,BRCA2,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,17924331 +OncoKB,BRCA2,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,17924331 +OncoKB,BRCA2,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,17924331 +OncoKB,BRCA2,Likely Neutral,NA,COF,NA,NA,NA,NA,"17924331, 18375895, 18824701" +OncoKB,BRCA2,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,18375895 +OncoKB,BRCA2,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,17924331 +OncoKB,BRCA2,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,17924331 +OncoKB,BRCA2,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,17924331 +OncoKB,BRCA2,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,18824701 +OncoKB,BRCA2,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,17924331 +OncoKB,BRCA2,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,18375895 +OncoKB,BRCA2,Oncogenic,NA,LOF,NA,NA,NA,NA,"12483515, 18501021, 27452521, 11239455, 22193408, 16199546" +OncoKB,BRCA2,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,18824701 +OncoKB,BRCA2,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,17924331 +OncoKB,BRCA2,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,18451181 +OncoKB,BRCA2,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,17924331 +OncoKB,BRCA2,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,17924331 +OncoKB,BRCA2,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,16489001 +OncoKB,BRCA2,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,17924331 +OncoKB,BRCA2,Likely Neutral,NA,COF,NA,NA,NA,NA,"16489001, 18824701" +OncoKB,BRCA2,Likely Neutral,NA,COF,NA,NA,NA,NA,"17924331, 18451181" +OncoKB,BRCA2,Likely Neutral,NA,COF,NA,NA,NA,NA,22962691 +OncoKB,BRCA2,Likely Neutral,NA,COF,NA,NA,NA,NA,"17924331, 18451181, 18824701" +OncoKB,BRCA2,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,17924331 +OncoKB,BRCA2,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,17924331 +OncoKB,BRCA2,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,17924331 +OncoKB,BRCA2,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,18824701 +OncoKB,BRCA2,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,17924331 +OncoKB,BRCA2,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,17924331 +OncoKB,BRCA2,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,17924331 +OncoKB,BRCA2,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,17924331 +OncoKB,BRCA2,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"20878484, 24312913, 11239455, 22193408, 10570174" +OncoKB,BRCA2,Likely Neutral,NA,COF,NA,NA,NA,NA,16489001 +OncoKB,BRCA2,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,18824701 +OncoKB,BRCA2,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,17924331 +OncoKB,BRCA2,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,21638052 +OncoKB,BRCA2,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"21947752, 23108138, 20694749" +OncoKB,BRCA2,Likely Neutral,NA,COF,NA,NA,NA,NA,"17924331, 18375895" +OncoKB,BRCA2,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,17924331 +OncoKB,BRCA2,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,18375895 +OncoKB,BRCA2,Likely Neutral,NA,COF,NA,NA,NA,NA,"17924331, 16489001" +OncoKB,BRCA2,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"22505045, 9150172" +OncoKB,BRCA2,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,17924331 +OncoKB,BRCA2,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,18451181 +OncoKB,BRCA2,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,17924331 +OncoKB,BRCA2,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,22505045 +OncoKB,BRCA2,Likely Neutral,NA,COF,NA,NA,NA,NA,18451181 +OncoKB,BRCA2,Likely Neutral,NA,COF,NA,NA,NA,NA,"17924331, 18451181" +OncoKB,BRCA2,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,17924331 +OncoKB,BRCA2,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,18824701 +OncoKB,BRCA2,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,18424508 +OncoKB,BRCA2,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,17924331 +OncoKB,BRCA2,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,"17924331, 18451181, 18489799" +OncoKB,BRCA2,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,17924331 +OncoKB,BRCA2,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"17924331, 18451181" +OncoKB,NF2,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"19545378, 8755919, 22825583, 9643284" +OncoKB,NF2,Likely Neutral,NA,COF,NA,NA,NA,NA,11448944 +OncoKB,NF2,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"21383154, 20178741" +OncoKB,NF2,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"21383154, 20178741, 10712203, 11448944" +OncoKB,NF2,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"21383154, 20178741" +OncoKB,NF2,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"20178741, 11448944" +OncoKB,NF2,Likely Neutral,NA,COF,NA,NA,NA,NA,"10712203, 11448944" +OncoKB,NF2,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"10712203, 11448944" +OncoKB,NF2,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,"21383154, 11448944" +OncoKB,NF2,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,11448944 +OncoKB,NF2,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,11448944 +OncoKB,NF2,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"24726726, 15645494, 19451229, 22825583, 9643284" +OncoKB,PAX8,Oncogenic,NA,GOF,NA,NA,NA,NA,"17131411, 10958784" +OncoKB,NFE2L2,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,"24142871, 18757741, 1875774" +OncoKB,NFE2L2,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"16888629, 26619011" +OncoKB,NFE2L2,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,12167159 +OncoKB,NFE2L2,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,"24142871, 18757741, 1875774" +OncoKB,NFE2L2,Oncogenic,NA,GOF,NA,NA,NA,NA,27147599 +OncoKB,NFE2L2,Oncogenic,NA,GOF,NA,NA,NA,NA,27147599 +OncoKB,NFE2L2,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,"24142871, 18757741, 1875774" +OncoKB,NFE2L2,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,"24142871, 18757741, 1875774" +OncoKB,NFE2L2,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,"24142871, 18757741, 1875774" +OncoKB,NFE2L2,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,"24142871, 18757741, 1875774" +OncoKB,NFE2L2,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,23365135 +OncoKB,NFE2L2,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,"24142871, 18757741, 1875774" +OncoKB,NFE2L2,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,"24142871, 18757741, 1875774" +OncoKB,NFE2L2,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,"24142871, 18757741, 1875774" +OncoKB,NFE2L2,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,"24142871, 18757741, 1875774" +OncoKB,NFE2L2,Oncogenic,NA,GOF,NA,NA,NA,NA,27147599 +OncoKB,NFE2L2,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"24130096, 18757741" +OncoKB,NFE2L2,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,"24142871, 18757741, 1875774" +OncoKB,NFE2L2,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,"24142871, 18757741, 1875774" +OncoKB,NFE2L2,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,"24142871, 18757741, 1875774" +OncoKB,NFE2L2,Oncogenic,NA,GOF,NA,NA,NA,NA,"24130096, 27147599, 18757741" +OncoKB,NFE2L2,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,"24142871, 18757741, 1875774" +OncoKB,NFE2L2,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,"24142871, 18757741, 1875774" +OncoKB,NFE2L2,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,"24142871, 18757741, 1875774" +OncoKB,GLI1,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,25476449 +OncoKB,GLI1,Oncogenic,NA,GOF,NA,NA,NA,NA,"3563490, 1825351" +OncoKB,FUBP1,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"22072542, 22588899, 21817013, 24117486" +OncoKB,BTK,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,"25189416, 24869598" +OncoKB,BTK,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"20052711, 20826165" +OncoKB,BTK,Likely Neutral,NA,LOF,NA,NA,NA,NA,"20052711, 9188445, 20826165" +OncoKB,NFKBIA,Likely Neutral,NA,Likely GOF,NA,NA,NA,NA,23708964 +OncoKB,NFKBIA,Likely Neutral,NA,Likely GOF,NA,NA,NA,NA,23864385 +OncoKB,NFKBIA,Likely Neutral,NA,GOF,NA,NA,NA,NA,18412279 +OncoKB,NFKBIA,Likely Neutral,NA,GOF,NA,NA,NA,NA,14523047 +OncoKB,GNA11,Oncogenic,NA,GOF,NA,NA,NA,NA,21083380 +OncoKB,GNA11,Oncogenic,NA,GOF,NA,NA,NA,NA,21083380 +OncoKB,KDR,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"18931684, 25411163, 21712447" +OncoKB,KDR,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"24793135, 24599305, 21712447" +OncoKB,KDR,Oncogenic,NA,GOF,NA,NA,NA,NA,"11114740, 26578684" +OncoKB,KDR,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,19723655 +OncoKB,KDR,Oncogenic,NA,GOF,NA,NA,NA,NA,19723655 +OncoKB,KDR,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,27004155 +OncoKB,KDR,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,"26422291, 19723655" +OncoKB,BCL10,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"10319863, 9989495" +OncoKB,BCL10,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"10319863, 9989495, 10845924" +OncoKB,GNAQ,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,22236444 +OncoKB,GNAQ,Oncogenic,NA,GOF,NA,NA,NA,NA,"19078957, 1328859, 21083380" +OncoKB,GNAS,Oncogenic,NA,GOF,NA,NA,NA,NA,"26257060, 24498386" +OncoKB,GNAS,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,2549426 +OncoKB,GNAS,Oncogenic,NA,GOF,NA,NA,NA,NA,"25288233, 20531296" +OncoKB,GNAS,Oncogenic,NA,GOF,NA,NA,NA,NA,"15148396, 19423757" +OncoKB,GNAS,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,2549426 +OncoKB,MGA,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,10601024 +OncoKB,MGA,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,23039309 +OncoKB,KIT,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"23775962, 18955458" +OncoKB,KIT,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"21689725, 18724244" +OncoKB,KIT,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,21642685 +OncoKB,KIT,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,16551858 +OncoKB,KIT,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"15650049, 18506689, 16166280, 21523721, 19779861, 15869870, 24868028, 17189383" +OncoKB,KIT,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,23775962 +OncoKB,KIT,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"16551858, 25239608, 16397263" +OncoKB,KIT,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,9168438 +OncoKB,KIT,Oncogenic,NA,GOF,NA,NA,NA,NA,"15790786, 16434489, 14645423, 16954519, 16397263" +OncoKB,KIT,Oncogenic,NA,GOF,NA,NA,NA,NA,"18235121, 12181401, 23076159, 17662946, 24061512, 18955458, 16098458, 15451219" +OncoKB,KIT,Oncogenic,NA,GOF,NA,NA,NA,NA,"15790786, 17372901, 18980976, 18955458, 16954519, 25605837, 15930355, 17699867, 9438854" +OncoKB,KIT,Likely Oncogenic,NA,Likely SOF,NA,NA,NA,NA,"14977822, 16551858, 18623623, 23840364, 25239608, 22614970, 18955458, 15930355, 17699867" +OncoKB,KIT,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,18955458 +OncoKB,KIT,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,25735500 +OncoKB,KIT,Oncogenic,NA,GOF,NA,NA,NA,NA,"25239608, 16954519" +OncoKB,KIT,Oncogenic,NA,GOF,NA,NA,NA,NA,"18235121, 17372901, 25079768, 12181401, 17046465, 19282169, 25641662, 16098458, 15451219, 23177515, 19536093" +OncoKB,KIT,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"18955458, 16954519" +OncoKB,KIT,Oncogenic,NA,GOF,NA,NA,NA,NA,24317392 +OncoKB,KIT,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"10224103, 25079768, 15342366" +OncoKB,KIT,Oncogenic,NA,GOF,NA,NA,NA,NA,15790786 +OncoKB,KIT,Oncogenic,NA,GOF,NA,NA,NA,NA,"14645423, 25239608, 16954519, 15930355, 17699867" +OncoKB,KIT,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,"16143141, 23599150" +OncoKB,KIT,Oncogenic,NA,GOF,NA,NA,NA,NA,15790786 +OncoKB,KIT,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"16551858, 15930355" +OncoKB,KIT,Oncogenic,NA,GOF,NA,NA,NA,NA,"22357254, 17372901, 26264378, 18980976, 25605837, 15930355, 19671763, 22068222, 23775962, 21642685, 25695690, 18955458, 16954519" +OncoKB,KIT,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,17259998 +OncoKB,KIT,Oncogenic,NA,GOF,NA,NA,NA,NA,"16551858, 17545544, 23840364, 16954519, 17699867" +OncoKB,KIT,Oncogenic,NA,GOF,NA,NA,NA,NA,"15790786, 23840364, 21482694, 24490049, 21642685, 25695690, 22614970, 16954519, 26316776, 17699867" +OncoKB,KIT,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"21969494, 22357254" +OncoKB,KIT,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"16551858, 18623623, 23840364, 18955458, 16954519, 21456006" +OncoKB,KIT,Oncogenic,NA,GOF,NA,NA,NA,NA,25239608 +OncoKB,KIT,Oncogenic,NA,GOF,NA,NA,NA,NA,"11526490, 25239608, 18955458, 16954519" +OncoKB,KIT,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,15930355 +OncoKB,KIT,Oncogenic,NA,GOF,NA,NA,NA,NA,21689725 +OncoKB,KIT,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,"14977822, 10224103, 19018266, 22357254, 21953054, 25079768, 21325067, 18980976, 21906875, 21642685, 20859122, 12888812" +OncoKB,KIT,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,21642685 +OncoKB,KIT,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"17139461, 18955458, 16954519" +OncoKB,KIT,Oncogenic,NA,GOF,NA,NA,NA,NA,"16954519, 9438854" +OncoKB,KIT,Oncogenic,NA,GOF,NA,NA,NA,NA,16397263 +OncoKB,KIT,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,22324351 +OncoKB,KIT,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,21642685 +OncoKB,KIT,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,16954519 +OncoKB,KIT,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"21690468, 22350270, 25239608" +OncoKB,KIT,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,16551858 +OncoKB,KIT,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,22357254 +OncoKB,KIT,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,"24211109, 16226710" +OncoKB,KIT,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,19865100 +OncoKB,KIT,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,11369651 +OncoKB,KIT,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,19865100 +OncoKB,KIT,Oncogenic,NA,GOF,NA,NA,NA,NA,"23348204, 12569358" +OncoKB,KIT,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,16952044 +OncoKB,KIT,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,18955458 +OncoKB,KIT,Oncogenic,NA,GOF,NA,NA,NA,NA,25239608 +OncoKB,KIT,Oncogenic,NA,GOF,NA,NA,NA,NA,9438854 +OncoKB,KIT,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,"14645423, 18955458, 16954519" +OncoKB,KIT,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,15930355 +OncoKB,KIT,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"15897563, 19812602, 16908931, 9438854" +OncoKB,KIT,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,18955458 +OncoKB,KIT,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"18955458, 16397263" +OncoKB,KIT,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,"18955458, 15930355" +OncoKB,KIT,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,"19802003, 12717247" +OncoKB,KIT,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"19461405, 25886408, 15685537" +OncoKB,KIT,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,18980976 +OncoKB,KIT,Oncogenic,NA,GOF,NA,NA,NA,NA,9438854 +OncoKB,KIT,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,19865100 +OncoKB,KIT,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,15690055 +OncoKB,KIT,Oncogenic,NA,GOF,NA,NA,NA,NA,"15790786, 15167915, 16397263, 15725473" +OncoKB,KIT,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"24419427, 18955458" +OncoKB,KIT,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,19865100 +OncoKB,KIT,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,"18623623, 23840364, 21642685, 18955458, 16954519, 16751810" +OncoKB,KIT,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,"22825855, 19603346, 16143141" +OncoKB,KIT,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,16551858 +OncoKB,KIT,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"15897563, 21642685, 25695690, 9438854" +OncoKB,KIT,Oncogenic,NA,GOF,NA,NA,NA,NA,"22350270, 25239608, 18955458, 16954519, 21527588, 17699867" +OncoKB,KIT,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"19369884, 17372901, 25079768" +OncoKB,KIT,Oncogenic,NA,GOF,NA,NA,NA,NA,"16551858, 15790786, 16954519" +OncoKB,KIT,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,15070706 +OncoKB,KIT,Oncogenic,NA,GOF,NA,NA,NA,NA,19861435 +OncoKB,KIT,Oncogenic,NA,GOF,NA,NA,NA,NA,12569358 +OncoKB,KIT,Oncogenic,NA,GOF,NA,NA,NA,NA,"18623623, 16956837, 18980976, 25304235, 25239608, 18955458, 16954519, 16397263" +OncoKB,KIT,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,22357254 +OncoKB,KIT,Likely Neutral,NA,COF,NA,NA,NA,NA,15790786 +OncoKB,KIT,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,17489795 +OncoKB,KIT,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,"12569358, 9438854" +OncoKB,KIT,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,"24855380, 23940219, 11526490, 25695690, 25304235, 25239608, 14645423, 16954519" +OncoKB,KIT,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,23840364 +OncoKB,KIT,Oncogenic,NA,GOF,NA,NA,NA,NA,"22357254, 16551858, 19861435, 15201427, 25605837" +OncoKB,KIT,Oncogenic,NA,GOF,NA,NA,NA,NA,"23775962, 16551858, 23840364, 25239608, 18955458, 16954519, 25605837, 9438854" +OncoKB,KIT,Oncogenic,NA,GOF,NA,NA,NA,NA,"20633291, 22069175, 16551858, 18623623, 22301675, 18980976, 22089421, 18955458, 16954519, 15930355" +OncoKB,KIT,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,18980976 +OncoKB,KIT,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"25015329, 21757432, 15790786, 20664593, 21498700, 18795925, 16307017" +OncoKB,KIT,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"23840364, 25239608, 18955458, 16954519" +OncoKB,KIT,Likely Neutral,NA,LOF,NA,NA,NA,NA,20824047 +OncoKB,KIT,Oncogenic,NA,GOF,NA,NA,NA,NA,"18235121, 17372901, 25079768, 12181401, 15365079, 16098458, 15451219" +OncoKB,KIT,Oncogenic,NA,GOF,NA,NA,NA,NA,"20339585, 16081693" +OncoKB,KIT,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,18955458 +OncoKB,KIT,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,"23993026, 15236194, 10485475, 16751810" +OncoKB,KIT,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,21642685 +OncoKB,KIT,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,21642685 +OncoKB,KIT,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,23567324 +OncoKB,KIT,Oncogenic,NA,GOF,NA,NA,NA,NA,15790786 +OncoKB,KIT,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,26863566 +OncoKB,KIT,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,25239608 +OncoKB,KIT,Oncogenic,NA,GOF,NA,NA,NA,NA,"15972446, 19193436, 7479840, 26002753, 16434489, 16397263, 15725473, 15790786, 17545544, 22301675, 16254134, 14645423, 16779792, 23659595, 23416972" +OncoKB,KIT,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"16551858, 16954519" +OncoKB,KIT,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,16954519 +OncoKB,KIT,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"18955458, 16954519, 15930355" +OncoKB,KIT,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"18623623, 18980976, 21642685, 25239608, 18955458" +OncoKB,KIT,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,25239608 +OncoKB,KIT,Oncogenic,NA,GOF,NA,NA,NA,NA,"18235121, 17372901, 25079768, 12181401, 15365079, 16098458, 15451219" +OncoKB,FGF19,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"24265351, 21397858, 22309595" +OncoKB,MED12,Oncogenic,NA,SOF,NA,NA,NA,NA,24746821 +OncoKB,MED12,Oncogenic,NA,GOF,NA,NA,NA,NA,24980722 +OncoKB,MED12,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,23178117 +OncoKB,MED12,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"12218053, 26619011, 17612495, 26383637" +OncoKB,MED12,Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"23738515, 25038752, 23913526, 21868628" +OncoKB,MED12,Oncogenic,NA,SOF,NA,NA,NA,NA,24746821 +OncoKB,NOTCH1,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"22077063, 23734977, 20852131" +OncoKB,NOTCH1,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"22056382, 24651013, 16618740, 25806268, 15472075, 16738328" +OncoKB,NOTCH1,Oncogenic,NA,GOF,NA,NA,NA,NA,"22056382, 24651013, 16618740, 25806268, 15472075, 16738328" +OncoKB,NOTCH1,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,"22056382, 24651013, 16618740, 25806268, 16738328" +OncoKB,NOTCH1,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,"22056382, 24651013, 16618740, 25806268, 16738328" +OncoKB,NOTCH1,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,"22056382, 24651013, 16618740, 25806268, 16738328" +OncoKB,NOTCH1,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"24651013, 25564152, 21948802, 15472075" +OncoKB,NOTCH1,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,"22056382, 24651013, 16618740, 25806268, 16738328" +OncoKB,NOTCH1,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,23999936 +OncoKB,NOTCH1,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"24651013, 25564152, 21948802, 15472075" +OncoKB,NOTCH1,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"24651013, 25564152, 21948802, 15472075" +OncoKB,NOTCH1,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,"22056382, 24651013, 16618740, 25806268, 16738328" +OncoKB,NOTCH1,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"24651013, 25564152, 21948802, 15472075" +OncoKB,NOTCH1,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"24651013, 25376516, 15472075, 19340001" +OncoKB,NOTCH1,Likely Neutral,NA,COF,NA,NA,NA,NA,"24651013, 16738328" +OncoKB,NOTCH1,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,"22056382, 24651013, 16618740, 25806268, 16738328" +OncoKB,NOTCH1,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"22056382, 24651013, 16618740, 25806268, 15472075, 16738328" +OncoKB,NOTCH1,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,"22056382, 24651013, 16618740, 25806268, 16738328" +OncoKB,NOTCH1,Oncogenic,NA,GOF,NA,NA,NA,NA,22101766 +OncoKB,NOTCH1,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,20823234 +OncoKB,NOTCH1,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"22056382, 24651013, 16618740, 25564152, 21948802, 25806268, 15472075" +OncoKB,NOTCH1,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"24651013, 25564152, 21948802, 15472075" +OncoKB,NOTCH1,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,"22056382, 24651013, 16618740, 25806268, 16738328" +OncoKB,NOTCH1,Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"24651013, 22006338, 21798897, 21798893" +OncoKB,NOTCH1,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,"22056382, 24651013, 16618740, 25806268, 16738328" +OncoKB,NOTCH1,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"24651013, 25564152, 21948802, 15472075" +OncoKB,NOTCH1,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"16688224, 22101766, 23033986" +OncoKB,NOTCH1,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,"22056382, 24651013, 16618740, 25806268, 16738328" +OncoKB,NOTCH1,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,"22056382, 24651013, 16618740, 25806268, 15472075, 16738328" +OncoKB,NOTCH1,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"24651013, 25564152, 21948802, 15472075" +OncoKB,NOTCH1,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"24651013, 25564152, 21948802, 15472075" +OncoKB,NOTCH1,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,"22056382, 24651013, 16618740, 25806268, 16738328" +OncoKB,NOTCH1,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,"24651013, 22006338, 27228302" +OncoKB,NOTCH1,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"24651013, 25564152, 21948802, 15472075" +OncoKB,NOTCH1,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,"22056382, 24651013, 16618740, 25806268, 16738328" +OncoKB,NOTCH2,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,21378989 +OncoKB,NOTCH2,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,22006338 +OncoKB,RAC1,Oncogenic,NA,GOF,NA,NA,NA,NA,"2546593, 22842228, 23284172, 25056119, 25465943" +OncoKB,RAC1,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,26619011 +OncoKB,RAC1,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,28115009 +OncoKB,RAC1,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,"24072884, 23474757" +OncoKB,RAC1,Oncogenic,NA,GOF,NA,NA,NA,NA,"23382236, 23284172" +OncoKB,RAC1,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,23382236 +OncoKB,RAC1,Oncogenic,NA,GOF,NA,NA,NA,NA,23382236 +OncoKB,DNMT3A,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"24656771, 27010239" +OncoKB,DNMT3A,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"22722925, 24167195, 24656771, 25416276, 27010239" +OncoKB,DNMT3A,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"21067377, 25964253, 24614070" +OncoKB,DNMT3A,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"21067377, 27636998" +OncoKB,DNMT3B,Likely Oncogenic,NA,Likely SOF,NA,NA,NA,NA,"20587527, 23315164, 25607950, 22815530, 17353906" +OncoKB,DNMT3B,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"25470049, 22810696" +OncoKB,RAD21,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"28116354, 25006131" +OncoKB,RAD21,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"28116354, 25006131" +OncoKB,RAD51,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA, +OncoKB,RAD51C,Likely Neutral,NA,COF,NA,NA,NA,NA,"21990120, 26261251, 20400964, 21980511" +OncoKB,RAD51C,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"20400963, 20400964, 21616938" +OncoKB,RAD51C,Likely Neutral,NA,COF,NA,NA,NA,NA,"21990120, 26261251, 20400964" +OncoKB,RAD51B,Likely Oncogenic,NA,Likely SOF,NA,NA,NA,NA,"9892177, 26787895, 11450849" +OncoKB,RAD51D,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"23372765, 21822267, 22986143" +OncoKB,KRAS,Oncogenic,NA,GOF,NA,NA,NA,NA,"25705018, 24256730, 16051643, 26841430" +OncoKB,KRAS,Oncogenic,NA,GOF,NA,NA,NA,NA,"17349581, 24300897, 19296721, 26037647, 11751631, 15093544, 20570890, 20147967" +OncoKB,KRAS,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,"3043178, 26841430" +OncoKB,KRAS,Oncogenic,NA,GOF,NA,NA,NA,NA,"20516123, 20949621, 25359494, 20570890, 12957286, 20147967" +OncoKB,KRAS,Likely Neutral,NA,COF,NA,NA,NA,NA,"22810696, 12506171" +OncoKB,KRAS,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,19075190 +OncoKB,KRAS,Oncogenic,NA,GOF,NA,NA,NA,NA,"25705018, 21079152" +OncoKB,KRAS,Oncogenic,NA,GOF,NA,NA,NA,NA,"21993244, 25363767, 24651010, 25437878" +OncoKB,KRAS,Oncogenic,NA,GOF,NA,NA,NA,NA,"20949621, 16474405, 18509354" +OncoKB,KRAS,Oncogenic,NA,GOF,NA,NA,NA,NA,23059812 +OncoKB,KRAS,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"20949621, 21263000" +OncoKB,KRAS,Oncogenic,NA,GOF,NA,NA,NA,NA,19490892 +OncoKB,KRAS,Oncogenic,NA,GOF,NA,NA,NA,NA,"20978259, 26037647, 22722830, 20147967" +OncoKB,KRAS,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,"26274561, 20147967" +OncoKB,KRAS,Oncogenic,NA,GOF,NA,NA,NA,NA,"8995293, 17875937, 20949621, 16474405" +OncoKB,KRAS,Oncogenic,NA,GOF,NA,NA,NA,NA,27147599 +OncoKB,KRAS,Oncogenic,NA,GOF,NA,NA,NA,NA,20949621 +OncoKB,KRAS,Oncogenic,NA,GOF,NA,NA,NA,NA,"20949621, 17601930, 7877967" +OncoKB,KRAS,Oncogenic,NA,GOF,NA,NA,NA,NA,"24893629, 26037647, 21831957, 22722830" +OncoKB,KRAS,Oncogenic,NA,GOF,NA,NA,NA,NA,"25705018, 21993244, 24651010, 20147967" +OncoKB,KRAS,Oncogenic,NA,GOF,NA,NA,NA,NA,"20570890, 20147967" +OncoKB,KRAS,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,"11333268, 26841430" +OncoKB,KRAS,Oncogenic,NA,GOF,NA,NA,NA,NA,24642870 +OncoKB,KRAS,Oncogenic,NA,GOF,NA,NA,NA,NA,"26662311, 26037647, 25013473, 23182985" +OncoKB,KRAS,Oncogenic,NA,GOF,NA,NA,NA,NA,"25600866, 20949621, 16474405" +OncoKB,KRAS,Oncogenic,NA,GOF,NA,NA,NA,NA,"17150185, 20147967" +OncoKB,KRAS,Oncogenic,NA,GOF,NA,NA,NA,NA,23059812 +OncoKB,KRAS,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,"11333268, 26841430" +OncoKB,KRAS,Oncogenic,NA,GOF,NA,NA,NA,NA,"26184075, 25284075" +OncoKB,KRAS,Oncogenic,NA,GOF,NA,NA,NA,NA,"17875937, 20949621" +OncoKB,KRAS,Oncogenic,NA,GOF,NA,NA,NA,NA,"25359213, 20949621, 16474405" +OncoKB,KRAS,Oncogenic,NA,GOF,NA,NA,NA,NA,"23059812, 11095964, 20570890" +OncoKB,KRAS,Oncogenic,NA,GOF,NA,NA,NA,NA,"12628188, 26841430" +OncoKB,KRAS,Oncogenic,NA,GOF,NA,NA,NA,NA,"20949621, 21263000" +OncoKB,KRAS,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"23099803, 24874471, 20841479, 23404247" +OncoKB,KRAS,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,21632860 +OncoKB,KRAS,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,20871262 +OncoKB,KRAS,Oncogenic,NA,GOF,NA,NA,NA,NA,"27147599, 1221964, 26841430" +OncoKB,KRAS,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"8552403, 11103938" +OncoKB,KRAS,Oncogenic,NA,GOF,NA,NA,NA,NA,"19075190, 20570890, 20147967, 2403644" +OncoKB,KRAS,Likely Neutral,NA,COF,NA,NA,NA,NA,"20570890, 16483931" +OncoKB,KRAS,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,21375404 +OncoKB,KRAS,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"19453520, 26619011, 17503413, 19521964" +OncoKB,KRAS,Oncogenic,NA,GOF,NA,NA,NA,NA,"17875937, 20949621, 25941399" +OncoKB,KRAS,Oncogenic,NA,GOF,NA,NA,NA,NA,"8626650, 24798740" +OncoKB,KRAS,Oncogenic,NA,GOF,NA,NA,NA,NA,"21993244, 25363767, 24651010, 26854029, 25437878" +OncoKB,KRAS,Oncogenic,NA,GOF,NA,NA,NA,NA,"17875937, 20949621, 16474405, 25941399" +OncoKB,KRAS,Oncogenic,NA,GOF,NA,NA,NA,NA,8955068 +OncoKB,KRAS,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,26841430 +OncoKB,NPM1,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"18212245, 19322210, 20877721, 16007073" +OncoKB,NPM1,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"19322210, 20877721" +OncoKB,RAF1,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,"12077328, 7867061, 17603483" +OncoKB,RAF1,Oncogenic,NA,GOF,NA,NA,NA,NA,"12077328, 7867061, 24569458, 17603483" +OncoKB,RAF1,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"27810072, 19363522, 20526349, 23637631" +OncoKB,RAF1,Oncogenic,NA,GOF,NA,NA,NA,NA,19357705 +OncoKB,RAF1,Oncogenic,NA,GOF,NA,NA,NA,NA,"24569458, 20679480" +OncoKB,RAF1,Oncogenic,NA,GOF,NA,NA,NA,NA,20526349 +OncoKB,RAF1,Oncogenic,NA,GOF,NA,NA,NA,NA,"16585161, 19357705" +OncoKB,RAF1,Oncogenic,NA,GOF,NA,NA,NA,NA,"17603483, 20679480" +OncoKB,RAF1,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"17603483, 20679480" +OncoKB,RAF1,Oncogenic,NA,GOF,NA,NA,NA,NA,"11389083, 21215703, 16517112" +OncoKB,RAF1,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,23637631 +OncoKB,RAF1,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,20679480 +OncoKB,RAF1,Oncogenic,NA,GOF,NA,NA,NA,NA,19363522 +OncoKB,RAB35,Oncogenic,NA,GOF,NA,NA,NA,NA,26338797 +OncoKB,RAB35,Oncogenic,NA,GOF,NA,NA,NA,NA,26338797 +OncoKB,HNF1A,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"12574234, 18003757, 25793983" +OncoKB,HNF1A,Likely Neutral,NA,COF,NA,NA,NA,NA,21170474 +OncoKB,HNF1A,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"12574234, 25793983" +OncoKB,HNF1A,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"12574234, 9313763, 16917892" +OncoKB,AKT3,Oncogenic,NA,GOF,NA,NA,NA,NA,"17178867, 24138071, 18451171, 25737557, 15466193, 20647317" +OncoKB,AKT3,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,18813315 +OncoKB,AKT3,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,22722202 +OncoKB,AKT3,Oncogenic,NA,GOF,NA,NA,NA,NA,22722202 +OncoKB,TCF3,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,"24492847, 22885699" +OncoKB,TCF7L2,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"10919662, 16547505, 18478343, 18599616, 10485457" +OncoKB,RARA,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,"27148563, 23670176, 19865110, 11438209" +OncoKB,NRAS,Oncogenic,NA,GOF,NA,NA,NA,NA,"25277205, 21993244, 20194776, 23515407, 24651010, 19492075" +OncoKB,NRAS,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"21993244, 24651010" +OncoKB,NRAS,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,"26266759, 25263998, 22876308" +OncoKB,NRAS,Oncogenic,NA,GOF,NA,NA,NA,NA,"26037647, 21993244, 24651010, 22722830" +OncoKB,NRAS,Oncogenic,NA,GOF,NA,NA,NA,NA,"21993244, 24651010" +OncoKB,NRAS,Oncogenic,NA,GOF,NA,NA,NA,NA,"21993244, 20194776, 23515407, 24651010" +OncoKB,NRAS,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"20371679, 21993244, 24651010" +OncoKB,NRAS,Oncogenic,NA,GOF,NA,NA,NA,NA,"25277205, 21993244, 20194776, 23515407, 24651010, 19492075" +OncoKB,NRAS,Oncogenic,NA,GOF,NA,NA,NA,NA,"25277205, 21993244, 20194776, 23515407, 24651010, 19492075" +OncoKB,NRAS,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"22817889, 19966803" +OncoKB,NRAS,Oncogenic,NA,GOF,NA,NA,NA,NA,"21993244, 23687087, 24651010, 25252692, 18372904" +OncoKB,NRAS,Oncogenic,NA,GOF,NA,NA,NA,NA,"18952898, 21993244, 21478863, 24651010" +OncoKB,NRAS,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,"19075190, 19966803, 10716188, 21263000" +OncoKB,NRAS,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"24265153, 16474405" +OncoKB,RASA1,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"2173144, 9121432, 9034330, 1689011" +OncoKB,RASA1,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,26993606 +OncoKB,RASA1,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"2173144, 9121432, 9034330, 1689011, 24038909" +OncoKB,RASA1,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,26993606 +OncoKB,BCL2L11,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"24737648, 23382048, 26076815, 23559152, 21652541, 26001141, 23116058" +OncoKB,BCL2L11,Oncogenic,NA,LOF,NA,NA,NA,NA,24223824 +OncoKB,BCL2L11,Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"22426421, 26076815, 23559152, 23116058" +OncoKB,RB1,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,"16449662, 7927327, 9420334, 1352883, 18677112" +OncoKB,RB1,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"25621664, 22293180, 22205104" +OncoKB,RB1,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,20594292 +OncoKB,RB1,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,18677112 +OncoKB,RB1,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,20594292 +OncoKB,RB1,Likely Neutral,NA,COF,NA,NA,NA,NA,18677112 +OncoKB,RB1,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,20594292 +OncoKB,RB1,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"16127685, 17854503, 23960888" +OncoKB,RB1,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"10671068, 9420334" +OncoKB,RB1,Likely Neutral,NA,COF,NA,NA,NA,NA,18677112 +OncoKB,RB1,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,"16269091, 10882758" +OncoKB,KDM5A,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"22937203, 2293720" +OncoKB,NTRK1,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,"7565764, 9488046" +OncoKB,NTRK1,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,24162815 +OncoKB,NTRK1,Oncogenic,NA,GOF,NA,NA,NA,NA,24647444 +OncoKB,NTRK1,Oncogenic,NA,GOF,NA,NA,NA,NA,"2869410, 2927393, 24962792" +OncoKB,NTRK1,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,18270328 +OncoKB,NTRK1,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,24647444 +OncoKB,NTRK1,Likely Neutral,NA,LOF,NA,NA,NA,NA,27272783 +OncoKB,NTRK1,Oncogenic,NA,GOF,NA,NA,NA,NA,11073967 +OncoKB,NTRK1,Oncogenic,NA,GOF,NA,NA,NA,NA,24445538 +OncoKB,NTRK1,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,26496938 +OncoKB,NTRK1,Oncogenic,NA,GOF,NA,NA,NA,NA,"9172002, 1532241, 7851906" +OncoKB,NTRK1,Oncogenic,NA,GOF,NA,NA,NA,NA,15488758 +OncoKB,NTRK1,Oncogenic,NA,GOF,NA,NA,NA,NA,24162815 +OncoKB,NTRK1,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,"1695324, 11313867, 23000897, 23636398, 22460905" +OncoKB,NTRK1,Oncogenic,NA,GOF,NA,NA,NA,NA,24162815 +OncoKB,NTRK1,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"24647444, 25384085" +OncoKB,NTRK1,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,"1695324, 11313867, 23636398, 22460905" +OncoKB,NTRK2,Likely Neutral,NA,Likely LOF,NA,NA,NA,NA,21242122 +OncoKB,NTRK2,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"26565381, 25204415, 26216294, 26884591, 24647444, 24445538, 26457764, 26797418, 24162815, 27843590, 26603524" +OncoKB,NTRK2,Likely Neutral,NA,Likely LOF,NA,NA,NA,NA,21242122 +OncoKB,NTRK2,Likely Neutral,NA,COF,NA,NA,NA,NA,21242122 +OncoKB,NTRK3,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"26565381, 25204415, 26216294, 26884591, 27843950, 26457764, 26797418, 27148571, 26603524" +OncoKB,NTRK3,Oncogenic,NA,GOF,NA,NA,NA,NA,"10702799, 12450792" +OncoKB,NTRK3,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,26884591 +OncoKB,NTRK3,Oncogenic,NA,GOF,NA,NA,NA,NA,24705251 +OncoKB,NTRK3,Oncogenic,NA,GOF,NA,NA,NA,NA,24705251 +OncoKB,DUSP4,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,"21317287, 19525976" +OncoKB,DDR2,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"24505276, 26362312, 28099935" +OncoKB,DDR2,Oncogenic,NA,GOF,NA,NA,NA,NA,"22328973, 23335507" +OncoKB,DDR2,Oncogenic,NA,GOF,NA,NA,NA,NA,"23822953, 22328973" +OncoKB,DDR2,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,"23822953, 22328973" +OncoKB,DDR2,Oncogenic,NA,GOF,NA,NA,NA,NA,22328973 +OncoKB,DDR2,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,24296828 +OncoKB,DDR2,Oncogenic,NA,GOF,NA,NA,NA,NA,"22328973, 23335507" +OncoKB,DDR2,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,"22328973, 24296828" +OncoKB,DDR2,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"22328973, 25173530" +OncoKB,DDR2,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,"23822953, 22328973" +OncoKB,SOX17,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"17655922, 28237397, 24407731, 20716954, 17875931, 18413743, 19301122, 27738313, 21514720, 24153254, 27102016, 22846201" +OncoKB,SOX17,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA, +OncoKB,NSD1,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"11895789, 23630019" +OncoKB,NSD1,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"11895789, 23630019, 27889185" +OncoKB,CASP8,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"15531912, 19852930, 15705878, 12949717" +OncoKB,CASP8,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,23659359 +OncoKB,CASP8,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,"16397500, 10969767, 11593392" +OncoKB,CASP8,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,"12010809, 10860845, 15735742, 16374545" +OncoKB,CASP8,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"15531912, 12055196, 15705878" +OncoKB,CASP8,Likely Neutral,NA,COF,NA,NA,NA,NA,12353035 +OncoKB,RET,Oncogenic,NA,GOF,NA,NA,NA,NA,9230192 +OncoKB,RET,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,21810974 +OncoKB,RET,Oncogenic,NA,GOF,NA,NA,NA,NA,17047083 +OncoKB,RET,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,10445857 +OncoKB,RET,Oncogenic,NA,GOF,NA,NA,NA,NA,9230192 +OncoKB,RET,Oncogenic,NA,GOF,NA,NA,NA,NA,21551259 +OncoKB,RET,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"15184865, 9242375" +OncoKB,RET,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"25064355, 24561444, 22327623" +OncoKB,RET,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,9191060 +OncoKB,RET,Oncogenic,NA,GOF,NA,NA,NA,NA,9230192 +OncoKB,RET,Likely Neutral,NA,LOF,NA,NA,NA,NA,11438491 +OncoKB,RET,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"17664273, 9230192" +OncoKB,RET,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"20103606, 21551259" +OncoKB,RET,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,21810974 +OncoKB,RET,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"15277225, 11746981" +OncoKB,RET,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,21810974 +OncoKB,RET,Oncogenic,NA,GOF,NA,NA,NA,NA,9230192 +OncoKB,RET,Oncogenic,NA,GOF,NA,NA,NA,NA,"24561444, 20554711" +OncoKB,RET,Oncogenic,NA,GOF,NA,NA,NA,NA,"20444924, 15753368" +OncoKB,RET,Oncogenic,NA,GOF,NA,NA,NA,NA,23578175 +OncoKB,RET,Likely Neutral,NA,LOF,NA,NA,NA,NA,11438491 +OncoKB,RET,Oncogenic,NA,GOF,NA,NA,NA,NA,"8755580, 22584710, 7824936, 9681850, 24561444" +OncoKB,RET,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,9230192 +OncoKB,RET,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,19186126 +OncoKB,RET,Likely Neutral,NA,LOF,NA,NA,NA,NA,11438491 +OncoKB,RET,Likely Neutral,NA,Likely LOF,NA,NA,NA,NA,15184865 +OncoKB,RET,Likely Neutral,NA,COF,NA,NA,NA,NA,"25733075, 24336963" +OncoKB,RET,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,21810974 +OncoKB,RET,Likely Neutral,NA,COF,NA,NA,NA,NA,21810974 +OncoKB,RET,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,15277225 +OncoKB,RET,Oncogenic,NA,GOF,NA,NA,NA,NA,22327624 +OncoKB,RET,Likely Neutral,NA,COF,NA,NA,NA,NA,10049754 +OncoKB,RET,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,"21711375, 11295841" +OncoKB,RET,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,16928683 +OncoKB,RET,Likely Neutral,NA,COF,NA,NA,NA,NA,10049754 +OncoKB,RET,Likely Neutral,NA,LOF,NA,NA,NA,NA,11438491 +OncoKB,RET,Likely Oncogenic,NA,Likely GOF,NA,NA,NA,NA,19029224 +OncoKB,RET,Likely Oncogenic,NA,GOF,NA,NA,NA,NA,"15753368, 9506724, 12490841, 17209045" +OncoKB,RET,Oncogenic,NA,GOF,NA,NA,NA,NA,9230192 +OncoKB,RET,Oncogenic,NA,GOF,NA,NA,NA,NA,24561444 +OncoKB,RET,Likely Neutral,NA,COF,NA,NA,NA,NA,11438491 +OncoKB,RET,Oncogenic,NA,GOF,NA,NA,NA,NA,9230192 +OncoKB,RET,Likely Neutral,NA,COF,NA,NA,NA,NA,21810974 +OncoKB,RET,Oncogenic,NA,GOF,NA,NA,NA,NA,"15531548, 21810974" +OncoKB,RET,Likely Neutral,NA,LOF,NA,NA,NA,NA,11438491 +OncoKB,RUNX1,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,"15864279, 15386419, 17394134" +OncoKB,RUNX1,Oncogenic,NA,LOF,NA,NA,NA,NA,"25490895, 21725049, 17290219" +OncoKB,RUNX1,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,10508512 +OncoKB,RUNX1,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,"19414342, 21174539, 4125056, 9819404" +OncoKB,RUNX1,Oncogenic,NA,GOF,NA,NA,NA,NA,25592647 +OncoKB,RUNX1,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,22318203 +OncoKB,RUNX1,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,22318203 +OncoKB,RUNX1,Oncogenic,NA,LOF,NA,NA,NA,NA,"18192504, 12393679" +OncoKB,RUNX1,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,22318203 +OncoKB,RUNX1,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,10508512 +OncoKB,RUNX1,Oncogenic,NA,LOF,NA,NA,NA,NA,"10068652, 11830488, 15156185" +OncoKB,RUNX1,Inconclusive,NA,Inconclusive,NA,NA,NA,NA,"18192504, 12874780, 12393679" +OncoKB,RUNX1,Oncogenic,NA,LOF,NA,NA,NA,NA,18192504 +OncoKB,RUNX1,Oncogenic,NA,LOF,NA,NA,NA,NA,18192504 +OncoKB,RUNX1,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,"11830488, 15156185" +OncoKB,RUNX1,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,"11830488, 15156185" +OncoKB,RUNX1,Oncogenic,NA,GOF,NA,NA,NA,NA,"26021490, 20549580" +OncoKB,RUNX1,Oncogenic,NA,LOF,NA,NA,NA,NA,"11830488, 18192504" +OncoKB,RUNX1,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,"15156182, 19016745" +OncoKB,RUNX1,Oncogenic,NA,LOF,NA,NA,NA,NA,18192504 +OncoKB,RUNX1,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,25893166 +OncoKB,RUNX1,Oncogenic,NA,LOF,NA,NA,NA,NA,18192504 +OncoKB,RUNX1,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,15156185 +OncoKB,RUNX1,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,21174539 +OncoKB,RUNX1,Likely Oncogenic,NA,Likely LOF,NA,NA,NA,NA,18192504 +OncoKB,RUNX1,Likely Oncogenic,NA,LOF,NA,NA,NA,NA,15156184 +Civic,gene,variant,disease,NA,NA,disease,NA,NA,pubmed_id +Civic,JAK2,V617F,Lymphoid Leukemia,NA,NA,Lymphoid Leukemia,NA,NA,16081687 +Civic,PDGFRA,D842V,Gastrointestinal Stromal Tumor,NA,NA,Gastrointestinal Stromal Tumor,NA,NA,15146165 +Civic,DNMT3A,R882,Acute Myeloid Leukemia,NA,NA,Acute Myeloid Leukemia,NA,NA,22081665 +Civic,DNMT3A,R882,Acute Myeloid Leukemia,NA,NA,Acute Myeloid Leukemia,NA,NA,22490330 +Civic,JAK2,V617F,Chronic Myeloid Leukemia,NA,NA,Chronic Myeloid Leukemia,NA,NA,16081687 +Civic,JAK2,V617F,Bone Marrow Cancer,NA,NA,Bone Marrow Cancer,NA,NA,19287384 +Civic,KRAS,G12,Acute Leukemia,NA,NA,Acute Leukemia,NA,NA,24571676 +Civic,NRAS,Q61,Melanoma,NA,NA,Melanoma,NA,NA,23861977 +Civic,DNMT3A,R882,Acute Myeloid Leukemia,NA,NA,Acute Myeloid Leukemia,NA,NA,22081665 +Civic,MAP2K1,P124S,Melanoma,NA,NA,Melanoma,NA,NA,19915144 +Civic,MAP2K1,Q56P,Melanoma,NA,NA,Melanoma,NA,NA,19915144 +Civic,NRAS,Q61,Melanoma,NA,NA,Melanoma,NA,NA,23569304 +Civic,PDGFRA,D842V,Gastrointestinal Stromal Tumor,NA,NA,Gastrointestinal Stromal Tumor,NA,NA,15928335 +Civic,PDGFRA,D842V,Gastrointestinal Stromal Tumor,NA,NA,Gastrointestinal Stromal Tumor,NA,NA,16954519 +Civic,ARAF,S214C,Non-small Cell Lung Carcinoma,NA,NA,Non-small Cell Lung Carcinoma,NA,NA,24569458 +Civic,DNMT3A,R882,Acute Myeloid Leukemia,NA,NA,Acute Myeloid Leukemia,NA,NA,22081665 +Civic,JAK2,V617F,Polycythemia Vera,NA,NA,Polycythemia Vera,NA,NA,16709929 +Civic,JAK2,V617F,Polycythemia Vera,NA,NA,Polycythemia Vera,NA,NA,18394554 +Civic,NRAS,G13D,Melanoma,NA,NA,Melanoma,NA,NA,18375819 +Civic,NRAS,Q61L,Melanoma,NA,NA,Melanoma,NA,NA,21576590 +Civic,NRAS,Q61R,Melanoma,NA,NA,Melanoma,NA,NA,21576590 +Civic,DNMT3A,R882,Acute Myeloid Leukemia,NA,NA,Acute Myeloid Leukemia,NA,NA,22081665 +Civic,DNMT3A,R882,Acute Myeloid Leukemia,NA,NA,Acute Myeloid Leukemia,NA,NA,21067377 +Civic,KIT,D816V,Acute Myeloid Leukemia,NA,NA,Acute Myeloid Leukemia,NA,NA,16384925 +Civic,NRAS,MUTATION,Colorectal Cancer,NA,NA,Colorectal Cancer,NA,NA,24666267 +Civic,BRAF,V600,Melanoma,NA,NA,Melanoma,NA,NA,21166657 +Civic,DNMT3A,R882,Acute Myeloid Leukemia,NA,NA,Acute Myeloid Leukemia,NA,NA,24512939 +Civic,ALK,F1174L,Inflammatory Myofibroblastic Tumor,NA,NA,Inflammatory Myofibroblastic Tumor,NA,NA,21030459 +Civic,ALK,F1174L,Non-small Cell Lung Carcinoma,NA,NA,Non-small Cell Lung Carcinoma,NA,NA,21030459 +Civic,KIT,L576P,Melanoma,NA,NA,Melanoma,NA,NA,19671763 +Civic,KRAS,EXON 2 MUTATION,Non-small Cell Lung Carcinoma,NA,NA,Non-small Cell Lung Carcinoma,NA,NA,15696205 +Civic,NRAS,Q61,Colorectal Cancer,NA,NA,Colorectal Cancer,NA,NA,20619739 +Civic,ALK,F1174L,Neuroblastoma,NA,NA,Neuroblastoma,NA,NA,21575866 +Civic,ALK,F1174L,Neuroblastoma,NA,NA,Neuroblastoma,NA,NA,21948233 +Civic,ALK,R1275Q,Neuroblastoma,NA,NA,Neuroblastoma,NA,NA,18923525 +Civic,ARAF,S214C,Non-small Cell Lung Carcinoma,NA,NA,Non-small Cell Lung Carcinoma,NA,NA,24569458 +Civic,ARAF,S214C,Non-small Cell Lung Carcinoma,NA,NA,Non-small Cell Lung Carcinoma,NA,NA,24569458 +Civic,KIT,L576P,Melanoma,NA,NA,Melanoma,NA,NA,19671763 +Civic,PDGFRA,D842I,Gastrointestinal Stromal Tumor,NA,NA,Gastrointestinal Stromal Tumor,NA,NA,22745105 +Civic,PDGFRA,D842V,Gastrointestinal Stromal Tumor,NA,NA,Gastrointestinal Stromal Tumor,NA,NA,22745105 +Civic,PDGFRA,D842Y,Gastrointestinal Stromal Tumor,NA,NA,Gastrointestinal Stromal Tumor,NA,NA,22745105 +Civic,PDGFRA,I843DEL,Gastrointestinal Stromal Tumor,NA,NA,Gastrointestinal Stromal Tumor,NA,NA,22745105 +Civic,PDGFRA,DI842-843VM,Gastrointestinal Stromal Tumor,NA,NA,Gastrointestinal Stromal Tumor,NA,NA,22745105 +Civic,ALK,R1275Q,Neuroblastoma,NA,NA,Neuroblastoma,NA,NA,18923525 +Civic,DNMT3A,R882,Acute Myeloid Leukemia,NA,NA,Acute Myeloid Leukemia,NA,NA,23632886 +Civic,DNMT3A,R882,Acute Myeloid Leukemia,NA,NA,Acute Myeloid Leukemia,NA,NA,23632886 +Civic,DNMT3A,R882,Acute Myeloid Leukemia,NA,NA,Acute Myeloid Leukemia,NA,NA,22490330 +Civic,FLT3,ITD,Acute Myeloid Leukemia,NA,NA,Acute Myeloid Leukemia,NA,NA,22490330 +Civic,KIT,EXON 11 MUTATION,Gastrointestinal Stromal Tumor,NA,NA,Gastrointestinal Stromal Tumor,NA,NA,16551858 +Civic,NRAS,MUTATION,Acute Myeloid Leukemia,NA,NA,Acute Myeloid Leukemia,NA,NA,15951308 +Civic,NRAS,G12,Acute Myeloid Leukemia,NA,NA,Acute Myeloid Leukemia,NA,NA,16434492 +Civic,KIT,EXON 11 MUTATION,Melanoma,NA,NA,Melanoma,NA,NA,23775962 +Civic,DNMT3A,R882,Acute Myeloid Leukemia,NA,NA,Acute Myeloid Leukemia,NA,NA,23632886 +Civic,DNMT3A,R882,Acute Myeloid Leukemia,NA,NA,Acute Myeloid Leukemia,NA,NA,21067377 +Civic,DNMT3A,R882,Acute Myeloid Leukemia,NA,NA,Acute Myeloid Leukemia,NA,NA,23632886 +Civic,DNMT3A,R882,Acute Myeloid Leukemia,NA,NA,Acute Myeloid Leukemia,NA,NA,21067377 +Civic,DNMT3A,R882,Acute Myeloid Leukemia,NA,NA,Acute Myeloid Leukemia,NA,NA,24512939 +Civic,DNMT3A,R882,Acute Myeloid Leukemia,NA,NA,Acute Myeloid Leukemia,NA,NA,22291079 +Civic,DNMT3A,R882,Acute Myeloid Leukemia,NA,NA,Acute Myeloid Leukemia,NA,NA,22490330 +Civic,DNMT3A,R882,Acute Myeloid Leukemia,NA,NA,Acute Myeloid Leukemia,NA,NA,22291079 +Civic,FLT3,ITD,Acute Myeloid Leukemia,NA,NA,Acute Myeloid Leukemia,NA,NA,21067377 +Civic,KIT,EXON 14 MUTATION,Gastrointestinal Stromal Tumor,NA,NA,Gastrointestinal Stromal Tumor,NA,NA,16551858 +Civic,NRAS,MUTATION,Melanoma,NA,NA,Melanoma,NA,NA,22180178 +Civic,BRAF,V600E+V600M,Melanoma,NA,NA,Melanoma,NA,NA,23031422 +Civic,RET,M918T,Thyroid Medullary Carcinoma,NA,NA,Thyroid Medullary Carcinoma,NA,NA,18073307 +Civic,RET,C634W,Thyroid Medullary Carcinoma,NA,NA,Thyroid Medullary Carcinoma,NA,NA,21422803 +Civic,RET,M918T,Thyroid Medullary Carcinoma,NA,NA,Thyroid Medullary Carcinoma,NA,NA,21422803 +Civic,RET,M918T,Thyroid Medullary Carcinoma,NA,NA,Thyroid Medullary Carcinoma,NA,NA,23056499 +Civic,RET,M918T,Thyroid Medullary Carcinoma,NA,NA,Thyroid Medullary Carcinoma,NA,NA,9839497 +Civic,BRAF,V600E,Thyroid Cancer,NA,NA,Thyroid Cancer,NA,NA,21594703 +Civic,BRAF,V600E,Thyroid Cancer,NA,NA,Thyroid Cancer,NA,NA,24570209 +Civic,BRAF,V600E,Melanoma,NA,NA,Melanoma,NA,NA,24586605 +Civic,PIK3CA,E542K,Colorectal Cancer,NA,NA,Colorectal Cancer,NA,NA,24559322 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Leukemia,NA,NA,Acute Myeloid Leukemia,NA,NA,23632886 +Civic,DNMT3A,R882,Acute Myeloid Leukemia,NA,NA,Acute Myeloid Leukemia,NA,NA,23632886 +Civic,NPM1,EXON 12 MUTATION,Acute Myeloid Leukemia,NA,NA,Acute Myeloid Leukemia,NA,NA,19357394 +Civic,NPM1,EXON 12 MUTATION,Acute Myeloid Leukemia,NA,NA,Acute Myeloid Leukemia,NA,NA,17957027 +Civic,NPM1,EXON 12 MUTATION,Acute Myeloid Leukemia,NA,NA,Acute Myeloid Leukemia,NA,NA,16076867 +Civic,NPM1,EXON 12 MUTATION,Acute Myeloid Leukemia,NA,NA,Acute Myeloid Leukemia,NA,NA,16455956 +Civic,NPM1,EXON 12 MUTATION,Acute Myeloid Leukemia,NA,NA,Acute Myeloid Leukemia,NA,NA,19059939 +Civic,NPM1,W288FS,Acute Myeloid Leukemia,NA,NA,Acute Myeloid Leukemia,NA,NA,21067377 +Civic,CEBPA,MUTATION,Acute Myeloid Leukemia,NA,NA,Acute Myeloid Leukemia,NA,NA,19965647 +Civic,PIK3CA,EXON 10 MUTATION,Colorectal Cancer,NA,NA,Colorectal Cancer,NA,NA,20619739 +Civic,NRAS,Q61,Colorectal Cancer,NA,NA,Colorectal Cancer,NA,NA,20619739 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MUTATION,Acute Myeloid Leukemia,NA,NA,Acute Myeloid Leukemia,NA,NA,18591546 +Civic,ALK,EML4-ALK L1196M,Non-small Cell Lung Carcinoma,NA,NA,Non-small Cell Lung Carcinoma,NA,NA,21575866 +Civic,ALK,F1174L,Neuroblastoma,NA,NA,Neuroblastoma,NA,NA,18923525 +Civic,ALK,R1275Q,Neuroblastoma,NA,NA,Neuroblastoma,NA,NA,22072639 +Civic,FGFR3,FGFR3-BAIAP2L1,Bladder Carcinoma,NA,NA,Bladder Carcinoma,NA,NA,23558953 +Civic,KRAS,G13D,Colorectal Cancer,NA,NA,Colorectal Cancer,NA,NA,20978259 +Civic,NPM1,EXON 12 MUTATION,Acute Myeloid Leukemia,NA,NA,Acute Myeloid Leukemia,NA,NA,19059939 +Civic,NPM1,EXON 12 MUTATION,Acute Myeloid Leukemia,NA,NA,Acute Myeloid Leukemia,NA,NA,22417203 +Civic,NPM1,EXON 12 MUTATION,Acute Myeloid Leukemia,NA,NA,Acute Myeloid Leukemia,NA,NA,24797300 +Civic,NPM1,EXON 12 MUTATION,Acute Myeloid Leukemia,NA,NA,Acute Myeloid Leukemia,NA,NA,21719597 +Civic,NPM1,EXON 12 MUTATION,Acute Myeloid Leukemia,NA,NA,Acute Myeloid Leukemia,NA,NA,24927407 +Civic,NPM1,EXON 12 MUTATION,Acute Myeloid Leukemia,NA,NA,Acute Myeloid Leukemia,NA,NA,24927407 +Civic,NPM1,W288FS,Acute Myeloid Leukemia,NA,NA,Acute Myeloid Leukemia,NA,NA,21719597 +Civic,NPM1,W288FS,Acute Myeloid Leukemia,NA,NA,Acute Myeloid Leukemia,NA,NA,15659725 +Civic,TSC1,FRAMESHIFT TRUNCATION,Non-small Cell Lung Carcinoma,NA,NA,Non-small Cell Lung Carcinoma,NA,NA,19966866 +Civic,TSC1,LOSS-OF-FUNCTION,Bladder Carcinoma,NA,NA,Bladder Carcinoma,NA,NA,22923433 +Civic,FLT3,MUTATION,Acute Myeloid Leukemia,NA,NA,Acute Myeloid Leukemia,NA,NA,14726504 +Civic,DNMT3A,R882,Acute Myeloid Leukemia,NA,NA,Acute Myeloid Leukemia,NA,NA,22291079 +Civic,FLT3,ITD,Acute Myeloid Leukemia,NA,NA,Acute Myeloid Leukemia,NA,NA,21537333 +Civic,FLT3,ITD,Acute Myeloid Leukemia,NA,NA,Acute Myeloid Leukemia,NA,NA,17957027 +Civic,IDH1,R132,Acute Myeloid Leukemia,NA,NA,Acute Myeloid Leukemia,NA,NA,20805365 +Civic,WT1,EXON 7 MUTATION,Acute Myeloid Leukemia,NA,NA,Acute Myeloid Leukemia,NA,NA,19221039 +Civic,WT1,EXON 7 MUTATION,Acute Myeloid Leukemia,NA,NA,Acute Myeloid Leukemia,NA,NA,19221039 +Civic,WT1,EXON 9 MUTATION,Acute Myeloid Leukemia,NA,NA,Acute Myeloid Leukemia,NA,NA,19221039 +Civic,CEBPA,MUTATION,Acute Myeloid Leukemia,NA,NA,Acute Myeloid Leukemia,NA,NA,19965647 +Civic,CEBPA,MUTATION,Acute Myeloid Leukemia,NA,NA,Acute Myeloid Leukemia,NA,NA,18450602 +Civic,CEBPA,MUTATION,Acute Myeloid Leukemia,NA,NA,Acute Myeloid Leukemia,NA,NA,14726504 +Civic,DNMT3A,R882,Acute Myeloid Leukemia,NA,NA,Acute Myeloid Leukemia,NA,NA,23632886 +Civic,FLT3,TKD MUTATION,Acute Myeloid Leukemia,NA,NA,Acute Myeloid Leukemia,NA,NA,17965322 +Civic,MGMT,PROMOTER METHYLATION,Glioblastoma Multiforme,NA,NA,Glioblastoma Multiforme,NA,NA,11070098 +Civic,NPM1,EXON 12 MUTATION,Acute Myeloid Leukemia,NA,NA,Acute Myeloid Leukemia,NA,NA,17957027 +Civic,NPM1,EXON 12 MUTATION,Acute Myeloid Leukemia,NA,NA,Acute Myeloid Leukemia,NA,NA,19059939 +Civic,NPM1,EXON 12 MUTATION,Acute Myeloid Leukemia,NA,NA,Acute Myeloid Leukemia,NA,NA,16455956 +Civic,NPM1,EXON 12 MUTATION,Acute Myeloid Leukemia,NA,NA,Acute Myeloid Leukemia,NA,NA,16076867 +Civic,NPM1,EXON 12 MUTATION,Acute Myeloid Leukemia,NA,NA,Acute Myeloid Leukemia,NA,NA,15659725 +Civic,NPM1,EXON 12 MUTATION,Acute Myeloid Leukemia,NA,NA,Acute Myeloid Leukemia,NA,NA,22417203 +Civic,NPM1,EXON 12 MUTATION,Acute Myeloid Leukemia,NA,NA,Acute Myeloid Leukemia,NA,NA,19047294 +Civic,NPM1,EXON 12 MUTATION,Acute Myeloid Leukemia,NA,NA,Acute Myeloid Leukemia,NA,NA,24855211 +Civic,NPM1,EXON 12 MUTATION,Acute Myeloid Leukemia,NA,NA,Acute Myeloid Leukemia,NA,NA,22430270 +Civic,NPM1,EXON 12 MUTATION,Acute Myeloid Leukemia,NA,NA,Acute Myeloid Leukemia,NA,NA,18450602 +Civic,NPM1,EXON 12 MUTATION,Acute Myeloid Leukemia,NA,NA,Acute Myeloid Leukemia,NA,NA,20026798 +Civic,NPM1,EXON 12 MUTATION,Acute Myeloid Leukemia,NA,NA,Acute Myeloid Leukemia,NA,NA,16051734 +Civic,DNMT3A,R882,Acute Myeloid Leukemia,NA,NA,Acute Myeloid Leukemia,NA,NA,22490330 +Civic,DNMT3A,R882,Acute Myeloid Leukemia,NA,NA,Acute Myeloid Leukemia,NA,NA,22291079 +Civic,DNMT3A,MUTATION,Acute Myeloid Leukemia,NA,NA,Acute Myeloid Leukemia,NA,NA,22490330 +Civic,DNMT3A,R882,Acute Myeloid Leukemia,NA,NA,Acute Myeloid Leukemia,NA,NA,22490330 +Civic,FLT3,ITD,Acute Myeloid Leukemia,NA,NA,Acute Myeloid Leukemia,NA,NA,24801015 +Civic,FLT3,ITD,Acute Myeloid Leukemia,NA,NA,Acute Myeloid Leukemia,NA,NA,21537333 +Civic,FLT3,ITD,Acute Myeloid Leukemia,NA,NA,Acute Myeloid Leukemia,NA,NA,21537333 +Civic,FLT3,ITD,Acute Myeloid Leukemia,NA,NA,Acute Myeloid Leukemia,NA,NA,21537333 +Civic,KRAS,G12/G13,Colorectal Cancer,NA,NA,Colorectal Cancer,NA,NA,18202412 +Civic,FLT3,ITD,Acute Myeloid Leukemia,NA,NA,Acute Myeloid Leukemia,NA,NA,16455956 +Civic,NPM1,EXON 12 MUTATION,Acute Myeloid Leukemia,NA,NA,Acute Myeloid Leukemia,NA,NA,19587375 +Civic,FLT3,ITD,Acute Myeloid Leukemia,NA,NA,Acute Myeloid Leukemia,NA,NA,24855211 +Civic,NPM1,EXON 12 MUTATION,Acute Myeloid Leukemia,NA,NA,Acute Myeloid Leukemia,NA,NA,24859829 +Civic,WT1,EXON 7 MUTATION,Acute Myeloid Leukemia,NA,NA,Acute Myeloid Leukemia,NA,NA,19536888 +Civic,WT1,EXON 7 MUTATION,Acute Myeloid Leukemia,NA,NA,Acute Myeloid Leukemia,NA,NA,19536888 +Civic,WT1,EXON 7 MUTATION,Acute Myeloid Leukemia,NA,NA,Acute Myeloid Leukemia,NA,NA,19221039 +Civic,WT1,EXON 7 MUTATION,Acute Myeloid Leukemia,NA,NA,Acute Myeloid Leukemia,NA,NA,18559874 +Civic,WT1,EXON 7 MUTATION,Acute Myeloid Leukemia,NA,NA,Acute Myeloid Leukemia,NA,NA,18591546 +Civic,WT1,EXON 7 MUTATION,Acute Myeloid Leukemia,NA,NA,Acute Myeloid Leukemia,NA,NA,18591546 +Civic,WT1,EXON 9 MUTATION,Acute Myeloid Leukemia,NA,NA,Acute Myeloid Leukemia,NA,NA,18559874 +Civic,BRCA1,LOSS-OF-FUNCTION,Ovarian Cancer,NA,NA,Ovarian Cancer,NA,NA,23346317 +Civic,BRCA2,LOSS-OF-FUNCTION,Ovarian Cancer,NA,NA,Ovarian Cancer,NA,NA,23346317 +Civic,ABL1,BCR-ABL,Chronic Myeloid Leukemia,NA,NA,Chronic Myeloid Leukemia,NA,NA,25212276 +Civic,FLT3,TKD MUTATION,Acute Myeloid Leukemia,NA,NA,Acute Myeloid Leukemia,NA,NA,11290608 +Civic,KRAS,G12,Non-small Cell Lung Carcinoma,NA,NA,Non-small Cell Lung Carcinoma,NA,NA,18794081 +Civic,U2AF1,Q157P/R,Acute Myeloid Leukemia,NA,NA,Acute Myeloid Leukemia,NA,NA,23029227 +Civic,U2AF1,S34Y/F,Acute Myeloid Leukemia,NA,NA,Acute Myeloid Leukemia,NA,NA,23029227 +Civic,CCND2,PROMOTER DEMETHYLATION,Stomach Cancer,NA,NA,Stomach Cancer,NA,NA,14612939 +Civic,ABL1,BCR-ABL,Chronic Myeloid Leukemia,NA,NA,Chronic Myeloid Leukemia,NA,NA,20537386 +Civic,CCND1,OVEREXPRESSION,Breast Cancer,NA,NA,Breast Cancer,NA,NA,15961768 +Civic,FLT3,ITD,Acute Myeloid Leukemia,NA,NA,Acute Myeloid Leukemia,NA,NA,11290608 +Civic,IDH1,R132,Acute Myeloid Leukemia,NA,NA,Acute Myeloid Leukemia,NA,NA,20376086 +Civic,IDH1,R132C,Acute Myeloid Leukemia,NA,NA,Acute Myeloid Leukemia,NA,NA,20538800 +Civic,KIT,EXON 11 MUTATION,Gastrointestinal Stromal Tumor,NA,NA,Gastrointestinal Stromal Tumor,NA,NA,10485475 +Civic,KRAS,G12C,Lung Cancer,NA,NA,Lung Cancer,NA,NA,23014527 +Civic,KRAS,G12D,Lung Cancer,NA,NA,Lung Cancer,NA,NA,23014527 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Carcinoma,NA,NA,Non-small Cell Lung Carcinoma,NA,NA,22328973 +Civic,DDR2,L239R,Non-small Cell Lung Carcinoma,NA,NA,Non-small Cell Lung Carcinoma,NA,NA,22328973 +Civic,DDR2,L63V,Non-small Cell Lung Carcinoma,NA,NA,Non-small Cell Lung Carcinoma,NA,NA,22328973 +Civic,DDR2,S768R,Non-small Cell Lung Carcinoma,NA,NA,Non-small Cell Lung Carcinoma,NA,NA,22328973 +Civic,EGFR,EXON 19 DELETION,Non-small Cell Lung Carcinoma,NA,NA,Non-small Cell Lung Carcinoma,NA,NA,16730237 +Civic,EGFR,G719S,Non-small Cell Lung Carcinoma,NA,NA,Non-small Cell Lung Carcinoma,NA,NA,15118125 +Civic,EGFR,L858R,Non-small Cell Lung Carcinoma,NA,NA,Non-small Cell Lung Carcinoma,NA,NA,24457318 +Civic,EGFR,L858R,Non-small Cell Lung Carcinoma,NA,NA,Non-small Cell Lung Carcinoma,NA,NA,15118125 +Civic,EGFR,T790M,Non-small Cell Lung Carcinoma,NA,NA,Non-small Cell Lung Carcinoma,NA,NA,24636847 +Civic,EGFR,T790M,Non-small Cell Lung Carcinoma,NA,NA,Non-small Cell Lung Carcinoma,NA,NA,24658966 +Civic,ERBB2,D769H,Breast Cancer,NA,NA,Breast Cancer,NA,NA,23220880 +Civic,ERBB2,D769Y,Breast Cancer,NA,NA,Breast Cancer,NA,NA,23220880 +Civic,ERBB2,DEL 755-759,Breast Cancer,NA,NA,Breast Cancer,NA,NA,23220880 +Civic,ERBB2,G309A,Breast Cancer,NA,NA,Breast Cancer,NA,NA,23220880 +Civic,ERBB2,L755S,Breast Cancer,NA,NA,Breast Cancer,NA,NA,23220880 +Civic,ERBB2,L755W,Breast Cancer,NA,NA,Breast Cancer,NA,NA,23220880 +Civic,ERBB2,P780INS,Breast Cancer,NA,NA,Breast Cancer,NA,NA,23220880 +Civic,ERBB2,R678Q,Breast Cancer,NA,NA,Breast Cancer,NA,NA,23220880 +Civic,ERBB2,R896C,Breast Cancer,NA,NA,Breast Cancer,NA,NA,23220880 +Civic,ERBB2,V777L,Breast Cancer,NA,NA,Breast Cancer,NA,NA,23220880 +Civic,ERBB2,V842I,Breast Cancer,NA,NA,Breast Cancer,NA,NA,23220880 +Civic,ESR1,L536Q,Breast Cancer,NA,NA,Breast Cancer,NA,NA,24185510 +Civic,ESR1,D538G,Breast Cancer,NA,NA,Breast Cancer,NA,NA,24185510 +Civic,ESR1,Y537C,Breast Cancer,NA,NA,Breast Cancer,NA,NA,24185510 +Civic,ESR1,Y537N,Breast Cancer,NA,NA,Breast Cancer,NA,NA,24185510 +Civic,ESR1,Y537S,Breast Cancer,NA,NA,Breast Cancer,NA,NA,24185510 +Civic,FGFR2,FGFR2-MGEA5,Cholangiocarcinoma,NA,NA,Cholangiocarcinoma,NA,NA,24550739 +Civic,FGFR2,FGFR2-TACC3,Cholangiocarcinoma,NA,NA,Cholangiocarcinoma,NA,NA,24550739 +Civic,FLT3,ITD,Acute Myeloid Leukemia,NA,NA,Acute Myeloid Leukemia,NA,NA,14726387 +Civic,FLT3,ITD,Acute Myeloid Leukemia,NA,NA,Acute Myeloid Leukemia,NA,NA,18230792 +Civic,FLT3,ITD,Acute Myeloid Leukemia,NA,NA,Acute Myeloid Leukemia,NA,NA,12357354 +Civic,GATA2,EXPRESSION,Bronchogenic Lung Adenocarcinoma,NA,NA,Bronchogenic Lung Adenocarcinoma,NA,NA,22541434 +Civic,KIT,INTERNAL DUPLICATION,Malignant Anus Melanoma,NA,NA,Malignant Anus Melanoma,NA,NA,18421059 +Civic,KIT,L576P,Non-small Cell Lung Carcinoma,NA,NA,Non-small Cell Lung Carcinoma,NA,NA,17372901 +Civic,KIT,V654A,Gastrointestinal Stromal Tumor,NA,NA,Gastrointestinal Stromal Tumor,NA,NA,16638875 +Civic,KRAS,G12D,Non-small Cell Lung Carcinoma,NA,NA,Non-small Cell Lung Carcinoma,NA,NA,19029981 +Civic,KRAS,G13D,Colorectal Cancer,NA,NA,Colorectal Cancer,NA,NA,20978259 +Civic,MGMT,PROMOTER METHYLATION,Glioblastoma Multiforme,NA,NA,Glioblastoma Multiforme,NA,NA,15758010 +Civic,MGMT,PROMOTER METHYLATION,Glioblastoma Multiforme,NA,NA,Glioblastoma Multiforme,NA,NA,11070098 +Civic,MGMT,PROMOTER METHYLATION,Glioblastoma Multiforme,NA,NA,Glioblastoma Multiforme,NA,NA,11070098 +Civic,PIK3CA,E542K,Breast Cancer,NA,NA,Breast Cancer,NA,NA,21558396 +Civic,PIK3CA,E542K,Breast Cancer,NA,NA,Breast Cancer,NA,NA,15647370 +Civic,PIK3CA,H1047R,Breast Cancer,NA,NA,Breast Cancer,NA,NA,21558396 +Civic,PML,PML-RARA,Acute Promyelocytic Leukemia,NA,NA,Acute Promyelocytic Leukemia,NA,NA,8674046 +Civic,PTEN,R233*,Breast Cancer,NA,NA,Breast Cancer,NA,NA,20085938 +Civic,TP53,R175H,Breast Cancer,NA,NA,Breast Cancer,NA,NA,22698404 +Civic,TSC1,FRAMESHIFT TRUNCATION,Invasive Bladder Transitional Cell Carcinoma,NA,NA,Invasive Bladder Transitional Cell Carcinoma,NA,NA,22923433 +Civic,FLT3,TKD MUTATION,Acute Myeloid Leukemia,NA,NA,Acute Myeloid Leukemia,NA,NA,11290608 +Civic,IDH1,R132,Acute Myeloid Leukemia,NA,NA,Acute Myeloid Leukemia,NA,NA,20368538 +Civic,IDH1,R132C,Acute Myeloid Leukemia,NA,NA,Acute Myeloid Leukemia,NA,NA,20538800 +Civic,IDH2,R140,Acute Myeloid Leukemia,NA,NA,Acute Myeloid Leukemia,NA,NA,22616558 +Civic,IDH2,MUTATION,Acute Myeloid Leukemia,NA,NA,Acute Myeloid Leukemia,NA,NA,20421455 +Civic,IDH2,R140,Myelodysplastic Syndrome,NA,NA,Myelodysplastic Syndrome,NA,NA,21997850 +Civic,IDH2,R140,Myelodysplastic Syndrome,NA,NA,Myelodysplastic Syndrome,NA,NA,22033490 +Civic,IDH2,R172K,Acute Myeloid Leukemia,NA,NA,Acute Myeloid Leukemia,NA,NA,22616558 +Civic,IDH2,R172K,Myelodysplastic Syndrome,NA,NA,Myelodysplastic Syndrome,NA,NA,21997850 +Civic,KIT,EXON 11 MUTATION,Gastrointestinal Stromal Tumor,NA,NA,Gastrointestinal Stromal Tumor,NA,NA,12000708 +Civic,KIT,EXON 11 MUTATION,Lung Cancer,NA,NA,Lung Cancer,NA,NA,15217946 +Civic,KRAS,G12,Colorectal Cancer,NA,NA,Colorectal Cancer,NA,NA,19934290 +Civic,KRAS,G12,Non-small Cell Lung Carcinoma,NA,NA,Non-small Cell Lung Carcinoma,NA,NA,11208838 +Civic,U2AF1,Q157P/R,Acute Myeloid Leukemia,NA,NA,Acute Myeloid Leukemia,NA,NA,23029227 +Civic,U2AF1,Q157P/R,Myelodysplastic Syndrome,NA,NA,Myelodysplastic Syndrome,NA,NA,23029227 +Civic,U2AF1,S34Y/F,Acute Myeloid Leukemia,NA,NA,Acute Myeloid Leukemia,NA,NA,23029227 +Civic,CCND1,EXPRESSION,Non-small Cell Lung Carcinoma,NA,NA,Non-small Cell Lung Carcinoma,NA,NA,17070615 +Civic,PTEN,R233*,Glioblastoma Multiforme,NA,NA,Glioblastoma Multiforme,NA,NA,22479427 +Civic,ABL1,BCR-ABL,Chronic Myeloid Leukemia,NA,NA,Chronic Myeloid Leukemia,NA,NA,20537386 +Civic,EGFR,L858R,Non-small Cell Lung Carcinoma,NA,NA,Non-small Cell Lung Carcinoma,NA,NA,24662454 +Civic,IDH1,R132,Astrocytoma,NA,NA,Astrocytoma,NA,NA,19933982 +Civic,IDH1,R132,Glioblastoma Multiforme,NA,NA,Glioblastoma Multiforme,NA,NA,20127344 +Civic,IDH2,R140,Acute Myeloid Leukemia,NA,NA,Acute Myeloid Leukemia,NA,NA,21596855 +Civic,SF3B1,MUTATION,Myelodysplastic Syndrome,NA,NA,Myelodysplastic Syndrome,NA,NA,21995386 +Civic,CCND1,AMPLIFICATION,Non-small Cell Lung Carcinoma,NA,NA,Non-small Cell Lung Carcinoma,NA,NA,17070615 +Civic,CCND1,EXPRESSION,Non-small Cell Lung Carcinoma,NA,NA,Non-small Cell Lung Carcinoma,NA,NA,17070615 +Civic,CCND1,OVEREXPRESSION,Breast Cancer,NA,NA,Breast Cancer,NA,NA,15961768 +Civic,CCND1,OVEREXPRESSION,Head And Neck Squamous Cell Carcinoma,NA,NA,Head And Neck Squamous Cell Carcinoma,NA,NA,16309541 +Civic,CCND1,OVEREXPRESSION,Mantle Cell Lymphoma,NA,NA,Mantle Cell Lymphoma,NA,NA,17891190 +Civic,CCND2,OVEREXPRESSION,Stomach Cancer,NA,NA,Stomach Cancer,NA,NA,10547574 +Civic,CCND2,OVEREXPRESSION,Stomach Cancer,NA,NA,Stomach Cancer,NA,NA,10547574 +Civic,CCND2,OVEREXPRESSION,Stomach Cancer,NA,NA,Stomach Cancer,NA,NA,10547574 +Civic,CCND2,OVEREXPRESSION,Stomach Cancer,NA,NA,Stomach Cancer,NA,NA,10547574 +Civic,CCNE1,OVEREXPRESSION,Breast Cancer,NA,NA,Breast Cancer,NA,NA,12432043 +Civic,CCNE1,OVEREXPRESSION,Gastric Adenosquamous Carcinoma,NA,NA,Gastric Adenosquamous Carcinoma,NA,NA,10224221 +Civic,CCNE1,OVEREXPRESSION,Gastric Adenosquamous Carcinoma,NA,NA,Gastric Adenosquamous Carcinoma,NA,NA,10224221 +Civic,CDKN2A,PROMOTER HYPERMETHYLATION,Non-small Cell Lung Carcinoma,NA,NA,Non-small Cell Lung Carcinoma,NA,NA,23111194 +Civic,EGFR,T790M,Non-small Cell Lung Carcinoma,NA,NA,Non-small Cell Lung Carcinoma,NA,NA,24623981 +Civic,EGFR,T790M,Non-small Cell Lung Carcinoma,NA,NA,Non-small Cell Lung Carcinoma,NA,NA,24729716 +Civic,FLT3,ITD,Acute Myeloid Leukemia,NA,NA,Acute Myeloid Leukemia,NA,NA,11290608 +Civic,FLT3,ITD,Acute Myeloid Leukemia,NA,NA,Acute Myeloid Leukemia,NA,NA,11585760 +Civic,FLT3,TKD MUTATION,Acute Myeloid Leukemia,NA,NA,Acute Myeloid Leukemia,NA,NA,17940205 +Civic,IDH1,R132,Myelodysplastic Syndrome,NA,NA,Myelodysplastic Syndrome,NA,NA,20494930 +Civic,IDH2,R172K,Acute Myeloid Leukemia,NA,NA,Acute Myeloid Leukemia,NA,NA,21596855 +Civic,KIT,EXON 11 MUTATION,Gastrointestinal Stromal Tumor,NA,NA,Gastrointestinal Stromal Tumor,NA,NA,10485475 +Civic,KRAS,G12,Multiple Myeloma,NA,NA,Multiple Myeloma,NA,NA,18528420 +Civic,KRAS,G12,Non-small Cell Lung Carcinoma,NA,NA,Non-small Cell Lung Carcinoma,NA,NA,15597105 +Civic,NOTCH1,D1642H,Non-small Cell Lung Carcinoma,NA,NA,Non-small Cell Lung Carcinoma,NA,NA,20007775 +Civic,NOTCH1,R2327W,Non-small Cell Lung Carcinoma,NA,NA,Non-small Cell Lung Carcinoma,NA,NA,20007775 +Civic,NOTCH1,S2275FS,Non-small Cell Lung Carcinoma,NA,NA,Non-small Cell Lung Carcinoma,NA,NA,20007775 +Civic,NOTCH1,V2444FS,Non-small Cell Lung Carcinoma,NA,NA,Non-small Cell Lung Carcinoma,NA,NA,20007775 +Civic,PIK3CA,E542K,Colorectal Cancer,NA,NA,Colorectal Cancer,NA,NA,22357840 +Civic,PIK3CA,E542K,Colorectal Cancer,NA,NA,Colorectal Cancer,NA,NA,19223544 +Civic,PIK3CA,E545K,Colorectal Cancer,NA,NA,Colorectal Cancer,NA,NA,19223544 +Civic,PIK3CA,H1047R,Colorectal Cancer,NA,NA,Colorectal Cancer,NA,NA,19223544 +Civic,TP53,R175H,Breast Cancer,NA,NA,Breast Cancer,NA,NA,16489069 +Civic,TP53,R248Q,Breast Cancer,NA,NA,Breast Cancer,NA,NA,16489069 +Civic,TP53,R248Q,Breast Cancer,NA,NA,Breast Cancer,NA,NA,9569050 +Civic,TP53,R248W,Breast Cancer,NA,NA,Breast Cancer,NA,NA,16489069 +Civic,TP53,R249,Breast Cancer,NA,NA,Breast Cancer,NA,NA,9569050 +Civic,TP53,R273C,Breast Cancer,NA,NA,Breast Cancer,NA,NA,16489069 +Civic,TP53,R273C,Breast Cancer,NA,NA,Breast Cancer,NA,NA,9569050 +Civic,TP53,R273H,Breast Cancer,NA,NA,Breast Cancer,NA,NA,16489069 +Civic,TP53,R273H,Breast Cancer,NA,NA,Breast Cancer,NA,NA,9569050 +Civic,TP53,R249,Breast Cancer,NA,NA,Breast Cancer,NA,NA,9569050 +Civic,U2AF1,Q157P/R,Myelodysplastic Syndrome,NA,NA,Myelodysplastic Syndrome,NA,NA,23861105 +Civic,U2AF1,S34Y/F,Myelodysplastic Syndrome,NA,NA,Myelodysplastic Syndrome,NA,NA,23861105 +Civic,CSF1R,MEF2D-CSF1R,Acute Lymphocytic Leukemia,NA,NA,Acute Lymphocytic Leukemia,NA,NA,24186003 +Civic,PRKACA,DNAJB1-PRKACA,Hepatocellular Fibrolamellar Carcinoma,NA,NA,Hepatocellular Fibrolamellar Carcinoma,NA,NA,24578576 +Civic,BCL2,IGH-BCL2,Diffuse Large B-cell Lymphoma,NA,NA,Diffuse Large B-cell Lymphoma,NA,NA,12075054 +Civic,FOXP1,AMPLIFICATION,Diffuse Large B-cell Lymphoma,NA,NA,Diffuse Large B-cell Lymphoma,NA,NA,18765795 +Civic,REL,AMPLIFICATION,Diffuse Large B-cell Lymphoma,NA,NA,Diffuse Large B-cell Lymphoma,NA,NA,12075054 +Civic,RUNX1,MUTATION,Acute Myeloid Leukemia,NA,NA,Acute Myeloid Leukemia,NA,NA,21343560 +Civic,IGF2,OVEREXPRESSION,Prostate Cancer,NA,NA,Prostate Cancer,NA,NA,25670080 +Civic,EGFR,EXON 19 DELETION,Non-small Cell Lung Carcinoma,NA,NA,Non-small Cell Lung Carcinoma,NA,NA,16818686 +Civic,IGF2,OVEREXPRESSION,Prostate Cancer,NA,NA,Prostate Cancer,NA,NA,25670080 +Civic,TET2,MUTATION,Acute Myeloid Leukemia,NA,NA,Acute Myeloid Leukemia,NA,NA,22430270 +Civic,AURKA,EXPRESSION,Ovarian Carcinoma,NA,NA,Ovarian Carcinoma,NA,NA,19157502 +Civic,TET2,MUTATION,Myelodysplastic Syndrome,NA,NA,Myelodysplastic Syndrome,NA,NA,19666869 +Civic,VHL,MUTATION,Renal Clear Cell Carcinoma,NA,NA,Renal Clear Cell Carcinoma,NA,NA,18464292 +Civic,TET2,MUTATION,Acute Myeloid Leukemia,NA,NA,Acute Myeloid Leukemia,NA,NA,22430270 +Civic,PBRM1,MUTATION,Renal Clear Cell Carcinoma,NA,NA,Renal Clear Cell Carcinoma,NA,NA,23620406 +Civic,TET2,MUTATION,Acute Myeloid Leukemia,NA,NA,Acute Myeloid Leukemia,NA,NA,21343549 +Civic,VHL,MUTATION,Renal Clear Cell Carcinoma,NA,NA,Renal Clear Cell Carcinoma,NA,NA,23620406 +Civic,BCL2,EXPRESSION,Diffuse Large B-cell Lymphoma,NA,NA,Diffuse Large B-cell Lymphoma,NA,NA,9207459 +Civic,BCL2,EXPRESSION,Diffuse Large B-cell Lymphoma,NA,NA,Diffuse Large B-cell Lymphoma,NA,NA,9207459 +Civic,EZH2,MUTATION,Myelodysplastic Syndrome,NA,NA,Myelodysplastic Syndrome,NA,NA,20601954 +Civic,TET2,MUTATION,Acute Myeloid Leukemia,NA,NA,Acute Myeloid Leukemia,NA,NA,21828143 +Civic,TET2,MUTATION,Acute Myeloid Leukemia,NA,NA,Acute Myeloid Leukemia,NA,NA,21343549 +Civic,VHL,LOSS-OF-FUNCTION,Renal Clear Cell Carcinoma,NA,NA,Renal Clear Cell Carcinoma,NA,NA,11793370 +Civic,RUNX1,MUTATION,Acute Myeloid Leukemia,NA,NA,Acute Myeloid Leukemia,NA,NA,21343560 +Civic,RUNX1,MUTATION,Acute Myeloid Leukemia,NA,NA,Acute Myeloid Leukemia,NA,NA,21343560 +Civic,FLI1,EWSR1-FLI1 Type 1,Ewing Sarcoma,NA,NA,Ewing Sarcoma,NA,NA,9552022 +Civic,EZH2,Y646,Diffuse Large B-cell Lymphoma,NA,NA,Diffuse Large B-cell Lymphoma,NA,NA,20081860 +Civic,EZH2,Y646,Follicular Lymphoma,NA,NA,Follicular Lymphoma,NA,NA,20081860 +Civic,KMT2D,LOSS-OF-FUNCTION,Follicular Lymphoma,NA,NA,Follicular Lymphoma,NA,NA,21796119 +Civic,BTK,C481S,Chronic Lymphocytic Leukemia,NA,NA,Chronic Lymphocytic Leukemia,NA,NA,24869598 +Civic,AKT1,Q79K,Melanoma,NA,NA,Melanoma,NA,NA,24265152 +Civic,ALK,EML4-ALK AMPLIFICATION,Non-small Cell Lung Carcinoma,NA,NA,Non-small Cell Lung Carcinoma,NA,NA,22277784 +Civic,ALK,ALK FUSION G1202R,Non-small Cell Lung Carcinoma,NA,NA,Non-small Cell Lung Carcinoma,NA,NA,22277784 +Civic,ALK,EML4-ALK L1196M,Non-small Cell Lung Carcinoma,NA,NA,Non-small Cell Lung Carcinoma,NA,NA,22277784 +Civic,ALK,EML4-ALK S1206Y,Non-small Cell Lung Carcinoma,NA,NA,Non-small Cell Lung Carcinoma,NA,NA,22277784 +Civic,ALK,EML4-ALK T1151INST,Non-small Cell Lung Carcinoma,NA,NA,Non-small Cell Lung Carcinoma,NA,NA,22277784 +Civic,APC,MUTATION,Colon Carcinoma,NA,NA,Colon Carcinoma,NA,NA,22440753 +Civic,APC,MUTATION,Colorectal Cancer,NA,NA,Colorectal Cancer,NA,NA,23539443 +Civic,AR,F877L,Prostate Cancer,NA,NA,Prostate Cancer,NA,NA,23779130 +Civic,AR,W742,Prostate Carcinoma,NA,NA,Prostate Carcinoma,NA,NA,12517791 +Civic,ASXL1,MUTATION,Acute Myeloid Leukemia,NA,NA,Acute Myeloid Leukemia,NA,NA,25412851 +Civic,ASXL1,MUTATION,Acute Myeloid Leukemia,NA,NA,Acute Myeloid Leukemia,NA,NA,25412851 +Civic,ASXL1,MUTATION,Acute Myeloid Leukemia,NA,NA,Acute Myeloid Leukemia,NA,NA,25308295 +Civic,ATM,MUTATION,Glioblastoma Multiforme,NA,NA,Glioblastoma Multiforme,NA,NA,23960094 +Civic,ATM,MUTATION,Melanoma,NA,NA,Melanoma,NA,NA,23960094 +Civic,ATM,UNDEREXPRESSION,Cancer,NA,NA,Cancer,NA,NA,23761041 +Civic,ATM,MUTATION,Hematologic Cancer,NA,NA,Hematologic Cancer,NA,NA,20739657 +Civic,AURKA,AMPLIFICATION,Esophagus Adenocarcinoma,NA,NA,Esophagus Adenocarcinoma,NA,NA,22302096 +Civic,AURKA,OVEREXPRESSION,Cervical Adenocarcinoma,NA,NA,Cervical Adenocarcinoma,NA,NA,12559175 +Civic,BAP1,EXPRESSION,Uveal Melanoma,NA,NA,Uveal Melanoma,NA,NA,25147369 +Civic,BAP1,MUTATION,Renal Clear Cell Carcinoma,NA,NA,Renal Clear Cell Carcinoma,NA,NA,23797736 +Civic,BAP1,MUTATION,Renal Clear Cell Carcinoma,NA,NA,Renal Clear Cell Carcinoma,NA,NA,23792563 +Civic,BRAF,AKAP9-BRAF,Papillary Thyroid Carcinoma,NA,NA,Papillary Thyroid Carcinoma,NA,NA,15630448 +Civic,BRAF,V600E,Myeloma,NA,NA,Myeloma,NA,NA,23612012 +Civic,BRCA1,MUTATION,Epithelial Ovarian Cancer,NA,NA,Epithelial Ovarian Cancer,NA,NA,22274685 +Civic,BRCA2,MUTATION,Epithelial Ovarian Cancer,NA,NA,Epithelial Ovarian Cancer,NA,NA,22274685 +Civic,CCNE1,AMPLIFICATION,Ovarian Carcinoma,NA,NA,Ovarian Carcinoma,NA,NA,20336784 +Civic,CEBPA,MUTATION,Acute Myeloid Leukemia,NA,NA,Acute Myeloid Leukemia,NA,NA,19304957 +Civic,CEBPA,MUTATION,Acute Myeloid Leukemia,NA,NA,Acute Myeloid Leukemia,NA,NA,25014773 +Civic,DNMT3A,MUTATION,T-cell Acute Lymphoblastic Leukemia,NA,NA,T-cell Acute Lymphoblastic Leukemia,NA,NA,23341344 +Civic,EGFR,AMPLIFICATION,Barrett's Adenocarcinoma,NA,NA,Barrett's Adenocarcinoma,NA,NA,20840671 +Civic,EGFR,AMPLIFICATION,Cervical Squamous Cell Carcinoma,NA,NA,Cervical Squamous Cell Carcinoma,NA,NA,21730982 +Civic,EGFR,COPY NUMBER VARIATION,Head And Neck Squamous Cell Carcinoma,NA,NA,Head And Neck Squamous Cell Carcinoma,NA,NA,17538160 +Civic,EGFR,AMPLIFICATION,Head And Neck Squamous Cell Carcinoma,NA,NA,Head And Neck Squamous Cell Carcinoma,NA,NA,16943533 +Civic,EGFR,OVEREXPRESSION,Supratentorial Glioblastoma Multiforme,NA,NA,Supratentorial Glioblastoma Multiforme,NA,NA,14583498 +Civic,ERG,EWSR1-ERG,Ewing Sarcoma,NA,NA,Ewing Sarcoma,NA,NA,23706910 +Civic,ERG,TMPRSS2-ERG,Prostate Carcinoma,NA,NA,Prostate Carcinoma,NA,NA,16254181 +Civic,FGFR3,Y375C,Bladder Carcinoma,NA,NA,Bladder Carcinoma,NA,NA,20542753 +Civic,FLI1,EWSR1-FLI1,Ewing Sarcoma,NA,NA,Ewing Sarcoma,NA,NA,23706910 +Civic,FOXL2,C134W,Ovarian Granulosa Cell Tumor,NA,NA,Ovarian Granulosa Cell Tumor,NA,NA,20693978 +Civic,IDH1,R132,Glioblastoma Multiforme,NA,NA,Glioblastoma Multiforme,NA,NA,19228619 +Civic,IDH1,R132,Astrocytoma,NA,NA,Astrocytoma,NA,NA,19228619 +Civic,IDH2,R172,Glioblastoma Multiforme,NA,NA,Glioblastoma Multiforme,NA,NA,19228619 +Civic,IDH2,R172,Astrocytoma,NA,NA,Astrocytoma,NA,NA,19228619 +Civic,IKZF1,DELETION,Precursor B Lymphoblastic Lymphoma/leukemia,NA,NA,Precursor B Lymphoblastic Lymphoma/leukemia,NA,NA,22699455 +Civic,KIT,M541L,Chronic Myeloid Leukemia,NA,NA,Chronic Myeloid Leukemia,NA,NA,16307017 +Civic,KIT,V560DEL,Thymic Carcinoma,NA,NA,Thymic Carcinoma,NA,NA,15201427 +Civic,KRAS,G12,Multiple Myeloma,NA,NA,Multiple Myeloma,NA,NA,18528420 +Civic,KRAS,G13,Multiple Myeloma,NA,NA,Multiple Myeloma,NA,NA,18528420 +Civic,KRAS,Q61,Multiple Myeloma,NA,NA,Multiple Myeloma,NA,NA,18528420 +Civic,MGMT,PROMOTER METHYLATION,Anaplastic Oligodendroglioma,NA,NA,Anaplastic Oligodendroglioma,NA,NA,19901104 +Civic,MGMT,PROMOTER METHYLATION,Glioblastoma Multiforme,NA,NA,Glioblastoma Multiforme,NA,NA,15758010 +Civic,NCOA3,AMPLIFICATION,Breast Cancer,NA,NA,Breast Cancer,NA,NA,23322234 +Civic,NCOA3,OVEREXPRESSION,Breast Cancer,NA,NA,Breast Cancer,NA,NA,23322234 +Civic,NOTCH1,MUTATION,Mantle Cell Lymphoma,NA,NA,Mantle Cell Lymphoma,NA,NA,22210878 +Civic,NOTCH1,P2514FS,Chronic Lymphocytic Leukemia,NA,NA,Chronic Lymphocytic Leukemia,NA,NA,21670202 +Civic,NRAS,MUTATION,Multiple Myeloma,NA,NA,Multiple Myeloma,NA,NA,18528420 +Civic,NRAS,Q61,Follicular Thyroid Carcinoma,NA,NA,Follicular Thyroid Carcinoma,NA,NA,22650231 +Civic,PAX8,PAX8-PPARG,Follicular Thyroid Carcinoma,NA,NA,Follicular Thyroid Carcinoma,NA,NA,12727991 +Civic,PBRM1,MUTATION,Renal Cell Carcinoma,NA,NA,Renal Cell Carcinoma,NA,NA,23333114 +Civic,PGR,EXPRESSION,Breast Cancer,NA,NA,Breast Cancer,NA,NA,16497822 +Civic,PGR,EXPRESSION,Breast Cancer,NA,NA,Breast Cancer,NA,NA,23280579 +Civic,PGR,EXPRESSION,Breast Cancer,NA,NA,Breast Cancer,NA,NA,21422407 +Civic,PGR,EXPRESSION,Breast Cancer,NA,NA,Breast Cancer,NA,NA,21422407 +Civic,PIK3CA,AMPLIFICATION,Gastric Adenocarcinoma,NA,NA,Gastric Adenocarcinoma,NA,NA,22292935 +Civic,PTEN,DELETION,Prostate Adenocarcinoma,NA,NA,Prostate Adenocarcinoma,NA,NA,17700571 +Civic,PTEN,LOSS,Colorectal Cancer,NA,NA,Colorectal Cancer,NA,NA,21163703 +Civic,PTEN,LOSS,Prostate Cancer,NA,NA,Prostate Cancer,NA,NA,11504908 +Civic,RUNX1,MUTATION,Acute Lymphocytic Leukemia,NA,NA,Acute Lymphocytic Leukemia,NA,NA,23341344 +Civic,RUNX1,MUTATION,Acute Myeloid Leukemia,NA,NA,Acute Myeloid Leukemia,NA,NA,22753902 +Civic,SF3B1,MUTATION,Chronic Lymphocytic Leukemia,NA,NA,Chronic Lymphocytic Leukemia,NA,NA,23568491 +Civic,SMAD4,MUTATION,Pancreatic Adenocarcinoma,NA,NA,Pancreatic Adenocarcinoma,NA,NA,19584151 +Civic,SMARCA4,MUTATION,Small Cell Carcinoma Of The Ovary Hypercalcemic Type,NA,NA,Small Cell Carcinoma Of The Ovary Hypercalcemic Type,NA,NA,24658004 +Civic,SMARCA4,INACTIVATING MUTATION,Lung Adenocarcinoma,NA,NA,Lung Adenocarcinoma,NA,NA,24658004 +Civic,TERT,AMPLIFICATION,Acral Lentiginous Melanoma,NA,NA,Acral Lentiginous Melanoma,NA,NA,25219713 +Civic,TERT,PROMOTER MUTATION,Skin Melanoma,NA,NA,Skin Melanoma,NA,NA,25217772 +Civic,TERT,PROMOTER MUTATION,Glioblastoma Multiforme,NA,NA,Glioblastoma Multiforme,NA,NA,23955565 +Civic,TP53,DELETERIOUS MUTATION,Head And Neck Squamous Cell Carcinoma,NA,NA,Head And Neck Squamous Cell Carcinoma,NA,NA,22090360 +Civic,TP53,MUTATION,Head And Neck Squamous Cell Carcinoma,NA,NA,Head And Neck Squamous Cell Carcinoma,NA,NA,8901856 +Civic,TP53,MUTATION,Esophagus Squamous Cell Carcinoma,NA,NA,Esophagus Squamous Cell Carcinoma,NA,NA,19941080 +Civic,TP53,MUTATION,Precursor B Lymphoblastic Lymphoma/leukemia,NA,NA,Precursor B Lymphoblastic Lymphoma/leukemia,NA,NA,22699455 +Civic,TP53,MUTATION,Myelodysplastic Syndrome,NA,NA,Myelodysplastic Syndrome,NA,NA,24836762 +Civic,TP53,MUTATION,Myeloma,NA,NA,Myeloma,NA,NA,17215851 +Civic,TP53,MUTATION,Head And Neck Squamous Cell Carcinoma,NA,NA,Head And Neck Squamous Cell Carcinoma,NA,NA,11325447 +Civic,TP53,MUTATION,Head And Neck Squamous Cell Carcinoma,NA,NA,Head And Neck Squamous Cell Carcinoma,NA,NA,11325447 +Civic,TP53,TRUNCATING MUTATION,Head And Neck Squamous Cell Carcinoma,NA,NA,Head And Neck Squamous Cell Carcinoma,NA,NA,21467160 +Civic,TP53,TRUNCATING MUTATION,Head And Neck Squamous Cell Carcinoma,NA,NA,Head And Neck Squamous Cell Carcinoma,NA,NA,21467160 +Civic,TTF1,AMPLIFICATION,Lung Adenocarcinoma,NA,NA,Lung Adenocarcinoma,NA,NA,19040416 +Civic,ERBB2,AMPLIFICATION,Breast Cancer,NA,NA,Breast Cancer,NA,NA,11248153 +Civic,ERBB2,AMPLIFICATION,Breast Cancer,NA,NA,Breast Cancer,NA,NA,15911866 +Civic,CHEK2,LOSS-OF-FUNCTION,Cancer,NA,NA,Cancer,NA,NA,10617473 +Civic,PRKACA,DNAJB1-PRKACA,Hepatocellular Fibrolamellar Carcinoma,NA,NA,Hepatocellular Fibrolamellar Carcinoma,NA,NA,25698061 +Civic,KRAS,G12/G13,Pancreatic Adenocarcinoma,NA,NA,Pancreatic Adenocarcinoma,NA,NA,24915778 +Civic,CDK12,LOSS-OF-FUNCTION,Ovarian Serous Carcinoma,NA,NA,Ovarian Serous Carcinoma,NA,NA,24240700 +Civic,IKZF1,DELETION,Precursor B Lymphoblastic Lymphoma/leukemia,NA,NA,Precursor B Lymphoblastic Lymphoma/leukemia,NA,NA,24366361 +Civic,IKZF1,DELETION,Acute Lymphocytic Leukemia,NA,NA,Acute Lymphocytic Leukemia,NA,NA,19770381 +Civic,IKZF1,DELETION,Acute Lymphocytic Leukemia,NA,NA,Acute Lymphocytic Leukemia,NA,NA,20445578 +Civic,IDH2,R172,Peripheral T-cell Lymphoma,NA,NA,Peripheral T-cell Lymphoma,NA,NA,26268241 +Civic,IDH2,R172,Peripheral T-cell Lymphoma,NA,NA,Peripheral T-cell Lymphoma,NA,NA,22215888 +Civic,IKZF1,DELETION,Precursor B Lymphoblastic Lymphoma/leukemia,NA,NA,Precursor B Lymphoblastic Lymphoma/leukemia,NA,NA,24740809 +Civic,NT5C2,R367Q,T-cell Acute Lymphoblastic Leukemia,NA,NA,T-cell Acute Lymphoblastic Leukemia,NA,NA,23377281 +Civic,NT5C2,K359Q,T-cell Acute Lymphoblastic Leukemia,NA,NA,T-cell Acute Lymphoblastic Leukemia,NA,NA,23377281 +Civic,NT5C2,D407A,T-cell Acute Lymphoblastic Leukemia,NA,NA,T-cell Acute Lymphoblastic Leukemia,NA,NA,23377281 +Civic,NT5C2,R367Q,T-cell Acute Lymphoblastic Leukemia,NA,NA,T-cell Acute Lymphoblastic Leukemia,NA,NA,23377281 +Civic,NT5C2,D407A,T-cell Acute Lymphoblastic Leukemia,NA,NA,T-cell Acute Lymphoblastic Leukemia,NA,NA,23377281 +Civic,NT5C2,K359Q,T-cell Acute Lymphoblastic Leukemia,NA,NA,T-cell Acute Lymphoblastic Leukemia,NA,NA,23377281 +Civic,ABL1,BCR-ABL F317L,Chronic Myeloid Leukemia,NA,NA,Chronic Myeloid Leukemia,NA,NA,18818391 +Civic,ABL1,BCR-ABL F317L,Chronic Myeloid Leukemia,NA,NA,Chronic Myeloid Leukemia,NA,NA,24236021 +Civic,ABL1,BCR-ABL F317L,Chronic Myeloid Leukemia,NA,NA,Chronic Myeloid Leukemia,NA,NA,25349473 +Civic,TP53,MUTATION,Precursor B Lymphoblastic Lymphoma/leukemia,NA,NA,Precursor B Lymphoblastic Lymphoma/leukemia,NA,NA,21747090 +Civic,TP53,DNA BINDING DOMAIN MUTATION,Oral Squamous Cell Carcinoma,NA,NA,Oral Squamous Cell Carcinoma,NA,NA,12509970 +Civic,EGFR,T790M,Lung Cancer,NA,NA,Lung Cancer,NA,NA,18227510 +Civic,PTEN,LOSS,Prostate Cancer,NA,NA,Prostate Cancer,NA,NA,17700571 +Civic,PTEN,LOSS,Bladder Carcinoma,NA,NA,Bladder Carcinoma,NA,NA,23989949 +Civic,PTEN,LOSS,Breast Cancer,NA,NA,Breast Cancer,NA,NA,24387334 +Civic,EGFR,T790M,Non-small Cell Lung Carcinoma,NA,NA,Non-small Cell Lung Carcinoma,NA,NA,25923550 +Civic,ATM,V2288FS*1,Prostate Cancer,NA,NA,Prostate Cancer,NA,NA,26510020 +Civic,ATM,N2875H,Prostate Cancer,NA,NA,Prostate Cancer,NA,NA,26510020 +Civic,NF2,Y177FS,Peritoneal Mesothelioma,NA,NA,Peritoneal Mesothelioma,NA,NA,25798586 +Civic,BRCA2,LOSS-OF-FUNCTION,Prostate Cancer,NA,NA,Prostate Cancer,NA,NA,26510020 +Civic,PDGFRA,D842V,Gastrointestinal Stromal Tumor,NA,NA,Gastrointestinal Stromal Tumor,NA,NA,12949711 +Civic,PDGFRA,V561A,Gastrointestinal Stromal Tumor,NA,NA,Gastrointestinal Stromal Tumor,NA,NA,12949711 +Civic,KIT,EXON 11 MUTATION,Gastrointestinal Stromal Tumor,NA,NA,Gastrointestinal Stromal Tumor,NA,NA,14645423 +Civic,TERT,C228T,Papillary Thyroid Carcinoma,NA,NA,Papillary Thyroid Carcinoma,NA,NA,25024077 +Civic,BRAF,V600E,Papillary Thyroid Carcinoma,NA,NA,Papillary Thyroid Carcinoma,NA,NA,25024077 +Civic,TERT,PROMOTER MUTATION,Thyroid Cancer,NA,NA,Thyroid Cancer,NA,NA,23766237 +Civic,TERT,PROMOTER MUTATION,Thyroid Cancer,NA,NA,Thyroid Cancer,NA,NA,23766237 +Civic,XRCC1,R194W,Non-small Cell Lung Carcinoma,NA,NA,Non-small Cell Lung Carcinoma,NA,NA,19157633 +Civic,GSTP1,DELETION,Ovarian Carcinoma,NA,NA,Ovarian Carcinoma,NA,NA,25010864 +Civic,BIRC7,AMPLIFICATION,Colon Cancer,NA,NA,Colon Cancer,NA,NA,23188704 +Civic,EGFR,EXON 4 DELETION,Epithelial Ovarian Cancer,NA,NA,Epithelial Ovarian Cancer,NA,NA,23764753 +Civic,KRAS,RS61764370,Epithelial Ovarian Cancer,NA,NA,Epithelial Ovarian Cancer,NA,NA,22139083 +Civic,ERCC5,RS751402,Parietal Lobe Ependymoma,NA,NA,Parietal Lobe Ependymoma,NA,NA,26338418 +Civic,KIT,3' UTR MUTATION,Acral Lentiginous Melanoma,NA,NA,Acral Lentiginous Melanoma,NA,NA,21119596 +Civic,NT5C2,K359Q,Acute Lymphocytic Leukemia,NA,NA,Acute Lymphocytic Leukemia,NA,NA,23377281 +Civic,EZH2,INTRON 6 MUTATION,Colorectal Cancer,NA,NA,Colorectal Cancer,NA,NA,21926398 +Civic,MTHFR,A222V,Stomach Cancer,NA,NA,Stomach Cancer,NA,NA,18704422 +Civic,GSTP1,I105V,Colorectal Cancer,NA,NA,Colorectal Cancer,NA,NA,19922504 +Civic,ABCG2,Q141K,Ovarian Cancer,NA,NA,Ovarian Cancer,NA,NA,22112610 +Civic,XRCC1,Q399R,Non-small Cell Lung Carcinoma,NA,NA,Non-small Cell Lung Carcinoma,NA,NA,22551904 +Civic,XRCC1,Q399R,Cervical Cancer,NA,NA,Cervical Cancer,NA,NA,16875718 +Civic,ABCB1,S893T,Ovarian Cancer,NA,NA,Ovarian Cancer,NA,NA,16467099 +Civic,ABCB1,I1145I,Non-small Cell Lung Carcinoma,NA,NA,Non-small Cell Lung Carcinoma,NA,NA,22296372 +Civic,ERCC2,K751Q,Osteosarcoma,NA,NA,Osteosarcoma,NA,NA,19434073 +Civic,ERCC2,K751Q,Non-small Cell Lung Carcinoma,NA,NA,Non-small Cell Lung Carcinoma,NA,NA,19470925 +Civic,TYMS,5' TANDEM REPEAT,Colorectal Cancer,NA,NA,Colorectal Cancer,NA,NA,20628391 +Civic,LRP1B,EXON 12–22 DELETION,Ovarian Cancer,NA,NA,Ovarian Cancer,NA,NA,22896685 +Civic,FGFR1,AMPLIFICATION,Lung Squamous Cell Carcinoma,NA,NA,Lung Squamous Cell Carcinoma,NA,NA,21160078 +Civic,FGFR1,EXPRESSION,Lung Cancer,NA,NA,Lung Cancer,NA,NA,24771645 +Civic,FGFR1,AMPLIFICATION,Lung Squamous Cell Carcinoma,NA,NA,Lung Squamous Cell Carcinoma,NA,NA,23182986 +Civic,FGFR1,AMPLIFICATION,Lung Squamous Cell Carcinoma,NA,NA,Lung Squamous Cell Carcinoma,NA,NA,25086725 +Civic,FGFR1,AMPLIFICATION,Non-small Cell Lung Carcinoma,NA,NA,Non-small Cell Lung Carcinoma,NA,NA,23806793 +Civic,FGFR1,AMPLIFICATION,Cancer,NA,NA,Cancer,NA,NA,25171497 +Civic,FGFR1,AMPLIFICATION,Non-small Cell Lung Carcinoma,NA,NA,Non-small Cell Lung Carcinoma,NA,NA,21666749 +Civic,FGFR1,AMPLIFICATION,Lung Squamous Cell Carcinoma,NA,NA,Lung Squamous Cell Carcinoma,NA,NA,25433983 +Civic,ROS1,REARRANGEMENT,Non-small Cell Lung Carcinoma,NA,NA,Non-small Cell Lung Carcinoma,NA,NA,25264305 +Civic,MET,AMPLIFICATION,Gastric Adenocarcinoma,NA,NA,Gastric Adenocarcinoma,NA,NA,22389872 +Civic,ATR,I774FS,Endometrial Cancer,NA,NA,Endometrial Cancer,NA,NA,19470935 +Civic,EGFR,AMPLIFICATION,Head And Neck Squamous Cell Carcinoma,NA,NA,Head And Neck Squamous Cell Carcinoma,NA,NA,21048039 +Civic,EGFR,OVEREXPRESSION,Head And Neck Squamous Cell Carcinoma,NA,NA,Head And Neck Squamous Cell Carcinoma,NA,NA,23265711 +Civic,EGFR,OVEREXPRESSION,Non-small Cell Lung Carcinoma,NA,NA,Non-small Cell Lung Carcinoma,NA,NA,22056021 +Civic,CDKN2A,p16 EXPRESSION,Head And Neck Squamous Cell Carcinoma,NA,NA,Head And Neck Squamous Cell Carcinoma,NA,NA,24577117 +Civic,CDKN2A,p16 EXPRESSION,Head And Neck Squamous Cell Carcinoma,NA,NA,Head And Neck Squamous Cell Carcinoma,NA,NA,24799460 +Civic,CDKN2A,p16 EXPRESSION,Head And Neck Squamous Cell Carcinoma,NA,NA,Head And Neck Squamous Cell Carcinoma,NA,NA,23746666 +Civic,CDKN2A,p16 EXPRESSION,Head And Neck Squamous Cell Carcinoma,NA,NA,Head And Neck Squamous Cell Carcinoma,NA,NA,24577089 +Civic,RET,KIF5B-RET,Lung Adenocarcinoma,NA,NA,Lung Adenocarcinoma,NA,NA,23584301 +Civic,HRAS,G13D,Colorectal Cancer,NA,NA,Colorectal Cancer,NA,NA,26561417 +Civic,HRAS,MUTATION,Cancer,NA,NA,Cancer,NA,NA,26544513 +Civic,CD274,EXPRESSION,Non-small Cell Lung Carcinoma,NA,NA,Non-small Cell Lung Carcinoma,NA,NA,26664143 +Civic,CD274,EXPRESSION,Lung Squamous Cell Carcinoma,NA,NA,Lung Squamous Cell Carcinoma,NA,NA,26313362 +Civic,CD274,EXPRESSION,Ovarian Serous Carcinoma,NA,NA,Ovarian Serous Carcinoma,NA,NA,26625204 +Civic,CD274,EXPRESSION,Melanoma,NA,NA,Melanoma,NA,NA,26086854 +Civic,MTOR,MUTATION,Bladder Carcinoma,NA,NA,Bladder Carcinoma,NA,NA,24625776 +Civic,AKT2,EXPRESSION,Breast Cancer,NA,NA,Breast Cancer,NA,NA,22842582 +Civic,AKT1,E17K,Melanoma,NA,NA,Melanoma,NA,NA,24735930 +Civic,PTEN,LOSS,Melanoma,NA,NA,Melanoma,NA,NA,24735930 +Civic,AKT1,E17K,Breast Cancer,NA,NA,Breast Cancer,NA,NA,26351323 +Civic,PIK3CA,E545K,Breast Cancer,NA,NA,Breast Cancer,NA,NA,23888070 +Civic,PTEN,LOSS,Breast Cancer,NA,NA,Breast Cancer,NA,NA,25398829 +Civic,MTOR,MUTATION,Melanoma,NA,NA,Melanoma,NA,NA,26490311 +Civic,MTOR,H1968Y,Melanoma,NA,NA,Melanoma,NA,NA,26490311 +Civic,PTEN,LOSS,Cancer,NA,NA,Cancer,NA,NA,25672916 +Civic,NF2,K159FS*16,Breast Cancer,NA,NA,Breast Cancer,NA,NA,25878190 +Civic,PTEN,LOSS,Breast Cancer,NA,NA,Breast Cancer,NA,NA,25409150 +Civic,EGFR,S492R,Colorectal Cancer,NA,NA,Colorectal Cancer,NA,NA,22270724 +Civic,FBXW7,MUTATION,Colorectal Cancer,NA,NA,Colorectal Cancer,NA,NA,26508446 +Civic,SMAD4,MUTATION,Colorectal Cancer,NA,NA,Colorectal Cancer,NA,NA,26508446 +Civic,SMAD4,UNDEREXPRESSION,Head And Neck Squamous Cell Carcinoma,NA,NA,Head And Neck Squamous Cell Carcinoma,NA,NA,26046389 +Civic,MTOR,P2213S,Melanoma,NA,NA,Melanoma,NA,NA,26490311 +Civic,BRAF,AGK-BRAF,Melanoma,NA,NA,Melanoma,NA,NA,23890088 +Civic,BRAF,AGK-BRAF,Melanoma,NA,NA,Melanoma,NA,NA,23890088 +Civic,BRAF,PAPSS1-BRAF,Melanoma,NA,NA,Melanoma,NA,NA,24345920 +Civic,BRAF,PAPSS1-BRAF,Melanoma,NA,NA,Melanoma,NA,NA,24345920 +Civic,BRAF,TRIM24-BRAF,Melanoma,NA,NA,Melanoma,NA,NA,24345920 +Civic,BRAF,L597R,Melanoma,NA,NA,Melanoma,NA,NA,23715574 +Civic,ERBB3,OVEREXPRESSION,Colorectal Cancer,NA,NA,Colorectal Cancer,NA,NA,25520391 +Civic,NT5E,OVEREXPRESSION,Colorectal Cancer,NA,NA,Colorectal Cancer,NA,NA,25520391 +Civic,EZH2,OVEREXPRESSION,Cancer,NA,NA,Cancer,NA,NA,26683709 +Civic,IDH1,R132C,Acute Myeloid Leukemia,NA,NA,Acute Myeloid Leukemia,NA,NA,26436839 +Civic,MET,AMPLIFICATION,Non-small Cell Lung Carcinoma,NA,NA,Non-small Cell Lung Carcinoma,NA,NA,17463250 +Civic,MYD88,OVEREXPRESSION,Breast Cancer,NA,NA,Breast Cancer,NA,NA,26596839 +Civic,MET,AMPLIFICATION,Non-small Cell Lung Carcinoma,NA,NA,Non-small Cell Lung Carcinoma,NA,NA,21623265 +Civic,MET,EXON 14 SKIPPING MUTATION,Cancer,NA,NA,Cancer,NA,NA,26547802 +Civic,EGFR,OVEREXPRESSION,Non-small Cell Lung Carcinoma,NA,NA,Non-small Cell Lung Carcinoma,NA,NA,26439803 +Civic,PDGFRA,D842V,Gastrointestinal Stromal Tumor,NA,NA,Gastrointestinal Stromal Tumor,NA,NA,26130666 +Civic,PIK3CA,P471L,Merkel Cell Carcinoma,NA,NA,Merkel Cell Carcinoma,NA,NA,26466009 +Civic,RET,EXPRESSION,Breast Cancer,NA,NA,Breast Cancer,NA,NA,26686064 +Civic,RIT1,OVEREXPRESSION,Endometrial Cancer,NA,NA,Endometrial Cancer,NA,NA,26617739 +Civic,RIT1,MUTATION,Lung Adenocarcinoma,NA,NA,Lung Adenocarcinoma,NA,NA,24469055 +Civic,CD274,EXPRESSION,Non-small Cell Lung Carcinoma,NA,NA,Non-small Cell Lung Carcinoma,NA,NA,26086854 +Civic,MYCN,AMPLIFICATION,Neuroblastoma,NA,NA,Neuroblastoma,NA,NA,26537256 +Civic,SMO,D473H,Brain Medulloblastoma,NA,NA,Brain Medulloblastoma,NA,NA,19726788 +Civic,SMO,MUTATION,Basal Cell Carcinoma,NA,NA,Basal Cell Carcinoma,NA,NA,25759020 +Civic,SMO,MUTATION,Basal Cell Carcinoma,NA,NA,Basal Cell Carcinoma,NA,NA,25759020 +Civic,PTCH1,MUTATION,Brain Medulloblastoma,NA,NA,Brain Medulloblastoma,NA,NA,24651015 +Civic,PTCH1,LOH,Brain Medulloblastoma,NA,NA,Brain Medulloblastoma,NA,NA,26169613 +Civic,STK11,EXON 1-2 MUTATION,Non-small Cell Lung Carcinoma,NA,NA,Non-small Cell Lung Carcinoma,NA,NA,26625312 +Civic,STK11,UNDEREXPRESSION,Prostate Cancer,NA,NA,Prostate Cancer,NA,NA,26391455 +Civic,SYK,OVEREXPRESSION,Ovarian Cancer,NA,NA,Ovarian Cancer,NA,NA,26096845 +Civic,CDKN2A,p16 EXPRESSION,Head And Neck Squamous Cell Carcinoma,NA,NA,Head And Neck Squamous Cell Carcinoma,NA,NA,23746666 +Civic,PRKACA,DNAJB1-PRKACA,Hepatocellular Fibrolamellar Carcinoma,NA,NA,Hepatocellular Fibrolamellar Carcinoma,NA,NA,25557953 +Civic,SMO,D473H,Basal Cell Carcinoma,NA,NA,Basal Cell Carcinoma,NA,NA,25759020 +Civic,PIK3CA,AMPLIFICATION,Epithelial Ovarian Cancer,NA,NA,Epithelial Ovarian Cancer,NA,NA,25370471 +Civic,BRAF,V600E,Melanoma,NA,NA,Melanoma,NA,NA,25370471 +Civic,CDKN2A,p16 EXPRESSION,Oropharynx Cancer,NA,NA,Oropharynx Cancer,NA,NA,20530316 +Civic,CDKN2A,p16 EXPRESSION,Oropharynx Cancer,NA,NA,Oropharynx Cancer,NA,NA,26712222 +Civic,ERBB2,AMPLIFICATION,Breast Cancer,NA,NA,Breast Cancer,NA,NA,18725974 +Civic,ERBB2,AMPLIFICATION,Breast Cancer,NA,NA,Breast Cancer,NA,NA,20142587 +Civic,EGFR,T790M,Non-small Cell Lung Carcinoma,NA,NA,Non-small Cell Lung Carcinoma,NA,NA,24065731 +Civic,ALK,EML4-ALK L1152R,Non-small Cell Lung Carcinoma,NA,NA,Non-small Cell Lung Carcinoma,NA,NA,21791641 +Civic,ALK,EML4-ALK G1269A,Non-small Cell Lung Carcinoma,NA,NA,Non-small Cell Lung Carcinoma,NA,NA,22235099 +Civic,ALK,EML4-ALK G1269A,Non-small Cell Lung Carcinoma,NA,NA,Non-small Cell Lung Carcinoma,NA,NA,23344087 +Civic,ALK,EML4-ALK AMPLIFICATION,Non-small Cell Lung Carcinoma,NA,NA,Non-small Cell Lung Carcinoma,NA,NA,22235099 +Civic,ALK,EML4-ALK AMPLIFICATION,Non-small Cell Lung Carcinoma,NA,NA,Non-small Cell Lung Carcinoma,NA,NA,23344087 +Civic,ERBB4,MUTATION,Melanoma,NA,NA,Melanoma,NA,NA,19718025 +Civic,PIK3CA,MUTATION,Colorectal Cancer,NA,NA,Colorectal Cancer,NA,NA,25242168 +Civic,EGFR,VIII,Glioblastoma Multiforme,NA,NA,Glioblastoma Multiforme,NA,NA,16282176 +Civic,EGFR,VIII,Glioblastoma Multiforme,NA,NA,Glioblastoma Multiforme,NA,NA,26423602 +Civic,PTEN,EXPRESSION,Glioblastoma Multiforme,NA,NA,Glioblastoma Multiforme,NA,NA,16282176 +Civic,PTEN,EXPRESSION,Glioblastoma Multiforme,NA,NA,Glioblastoma Multiforme,NA,NA,25939761 +Civic,NRG1,EXPRESSION,Head And Neck Squamous Cell Carcinoma,NA,NA,Head And Neck Squamous Cell Carcinoma,NA,NA,21840482 +Civic,NRG1,EXPRESSION,Colorectal Cancer,NA,NA,Colorectal Cancer,NA,NA,21900593 +Civic,NRG1,EXPRESSION,Ovarian Cancer,NA,NA,Ovarian Cancer,NA,NA,20227043 +Civic,NRG1,EXPRESSION,Non-small Cell Lung Carcinoma,NA,NA,Non-small Cell Lung Carcinoma,NA,NA,23390248 +Civic,AREG,EXPRESSION,Non-small Cell Lung Carcinoma,NA,NA,Non-small Cell Lung Carcinoma,NA,NA,21791641 +Civic,AREG,EXPRESSION,Non-small Cell Lung Carcinoma,NA,NA,Non-small Cell Lung Carcinoma,NA,NA,23344087 +Civic,EGFR,OVEREXPRESSION,Head And Neck Squamous Cell Carcinoma,NA,NA,Head And Neck Squamous Cell Carcinoma,NA,NA,9625170 +Civic,EGFR,OVEREXPRESSION,Esophagus Squamous Cell Carcinoma,NA,NA,Esophagus Squamous Cell Carcinoma,NA,NA,26459251 +Civic,EGFR,OVEREXPRESSION,Esophagus Squamous Cell Carcinoma,NA,NA,Esophagus Squamous Cell Carcinoma,NA,NA,26459251 +Civic,TGFA,EXPRESSION,Head And Neck Squamous Cell Carcinoma,NA,NA,Head And Neck Squamous Cell Carcinoma,NA,NA,9625170 +Civic,EGFR,G724S,Colorectal Cancer,NA,NA,Colorectal Cancer,NA,NA,24894453 +Civic,EGFR,G719S,Colorectal Cancer,NA,NA,Colorectal Cancer,NA,NA,24894453 +Civic,AREG,EXPRESSION,Colorectal Cancer,NA,NA,Colorectal Cancer,NA,NA,23374602 +Civic,EREG,EXPRESSION,Colorectal Cancer,NA,NA,Colorectal Cancer,NA,NA,23374602 +Civic,MAPK1,E322K,Head And Neck Squamous Cell Carcinoma,NA,NA,Head And Neck Squamous Cell Carcinoma,NA,NA,26181029 +Civic,MAPK1,AMPLIFICATION,Non-small Cell Lung Carcinoma,NA,NA,Non-small Cell Lung Carcinoma,NA,NA,22961667 +Civic,FGFR1,EXPRESSION,Breast Cancer,NA,NA,Breast Cancer,NA,NA,26673008 +Civic,KRAS,A146V,Non-small Cell Lung Carcinoma,NA,NA,Non-small Cell Lung Carcinoma,NA,NA,24836576 +Civic,KRAS,G12V,Non-small Cell Lung Carcinoma,NA,NA,Non-small Cell Lung Carcinoma,NA,NA,20609353 +Civic,MET,MUTATION,Papillary Renal Cell Carcinoma,NA,NA,Papillary Renal Cell Carcinoma,NA,NA,23213094 +Civic,MET,EXON 14 SKIPPING MUTATION,Lung Adenocarcinoma,NA,NA,Lung Adenocarcinoma,NA,NA,25971939 +Civic,FGFR1,EXPRESSION,Head And Neck Squamous Cell Carcinoma,NA,NA,Head And Neck Squamous Cell Carcinoma,NA,NA,26115874 +Civic,FGFR1,EXPRESSION,Head And Neck Squamous Cell Carcinoma,NA,NA,Head And Neck Squamous Cell Carcinoma,NA,NA,26015511 +Civic,FGFR1,EXPRESSION,Gastric Adenocarcinoma,NA,NA,Gastric Adenocarcinoma,NA,NA,26637881 +Civic,FGFR1,EXPRESSION,Bladder Carcinoma,NA,NA,Bladder Carcinoma,NA,NA,21119661 +Civic,FGFR3,EXPRESSION,Bladder Carcinoma,NA,NA,Bladder Carcinoma,NA,NA,21119661 +Civic,CDKN2A,p16 EXPRESSION,Head And Neck Squamous Cell Carcinoma,NA,NA,Head And Neck Squamous Cell Carcinoma,NA,NA,25267748 +Civic,CBLC,EXPRESSION,Cancer,NA,NA,Cancer,NA,NA,25883215 +Civic,KRAS,G13D,Colorectal Cancer,NA,NA,Colorectal Cancer,NA,NA,26623049 +Civic,PTPRD,MUTATION,Head And Neck Carcinoma,NA,NA,Head And Neck Carcinoma,NA,NA,26267899 +Civic,DEFA1,EXPRESSION,Prostate Cancer,NA,NA,Prostate Cancer,NA,NA,26261420 +Civic,ERCC1,EXPRESSION,Bladder Carcinoma,NA,NA,Bladder Carcinoma,NA,NA,26162296 +Civic,ERCC1,EXPRESSION,Bladder Carcinoma,NA,NA,Bladder Carcinoma,NA,NA,26162296 +Civic,NOTCH1,AMPLIFICATION,Colorectal Cancer,NA,NA,Colorectal Cancer,NA,NA,26152787 +Civic,NOTCH1,AMPLIFICATION,Colorectal Cancer,NA,NA,Colorectal Cancer,NA,NA,26152787 +Civic,NRG1,EXPRESSION,Non-small Cell Lung Carcinoma,NA,NA,Non-small Cell Lung Carcinoma,NA,NA,26137564 +Civic,WEE1,POLYMORPHISM,Non-small Cell Lung Carcinoma,NA,NA,Non-small Cell Lung Carcinoma,NA,NA,26057002 +Civic,FNTB,RS11623866,Ovarian Cancer,NA,NA,Ovarian Cancer,NA,NA,26033044 +Civic,BRAF,V600E,Colorectal Cancer,NA,NA,Colorectal Cancer,NA,NA,25989278 +Civic,PTPRT,PROMOTER HYPERMETHYLATION,Head And Neck Squamous Cell Carcinoma,NA,NA,Head And Neck Squamous Cell Carcinoma,NA,NA,25982282 +Civic,VEGFA,UNDEREXPRESSION,Colorectal Cancer,NA,NA,Colorectal Cancer,NA,NA,25973082 +Civic,DNMT1,EXPRESSION,Ovarian Cancer,NA,NA,Ovarian Cancer,NA,NA,25968887 +Civic,KRAS,MUTATION,Ovarian Cancer,NA,NA,Ovarian Cancer,NA,NA,25968887 +Civic,PDCD4,EXPRESSION,Lung Cancer,NA,NA,Lung Cancer,NA,NA,25928036 +Civic,MGMT,RS16906252,Glioblastoma Multiforme,NA,NA,Glioblastoma Multiforme,NA,NA,25910840 +Civic,TFF3,EXPRESSION,Breast Cancer,NA,NA,Breast Cancer,NA,NA,25900183 +Civic,DKK1,NUCLEAR EXPRESSION,Colorectal Cancer,NA,NA,Colorectal Cancer,NA,NA,25788273 +Civic,CD44,ISOFORM EXPRESSION,Cancer,NA,NA,Cancer,NA,NA,25762343 +Civic,EGF,EXPRESSION,Head And Neck Squamous Cell Carcinoma,NA,NA,Head And Neck Squamous Cell Carcinoma,NA,NA,25677871 +Civic,MDM2,EXPRESSION,Malignant Pleural Mesothelioma,NA,NA,Malignant Pleural Mesothelioma,NA,NA,25668009 +Civic,MDM2,EXPRESSION,Malignant Pleural Mesothelioma,NA,NA,Malignant Pleural Mesothelioma,NA,NA,25668009 +Civic,HMOX1,EXPRESSION,Renal Cell Carcinoma,NA,NA,Renal Cell Carcinoma,NA,NA,26309414 +Civic,SPHK1,OVEREXPRESSION,Cervical Cancer,NA,NA,Cervical Cancer,NA,NA,26311741 +Civic,CASP8,EXPRESSION,Bone Ewing's Sarcoma,NA,NA,Bone Ewing's Sarcoma,NA,NA,26291055 +Civic,TYMS,EXPRESSION,Non-small Cell Lung Carcinoma,NA,NA,Non-small Cell Lung Carcinoma,NA,NA,26502926 +Civic,PBK,OVEREXPRESSION,Non-small Cell Lung Carcinoma,NA,NA,Non-small Cell Lung Carcinoma,NA,NA,26745678 +Civic,MET,AMPLIFICATION,Lung Adenocarcinoma,NA,NA,Lung Adenocarcinoma,NA,NA,26724472 +Civic,SMARCA4,UNDEREXPRESSION,Non-small Cell Lung Carcinoma,NA,NA,Non-small Cell Lung Carcinoma,NA,NA,26671993 +Civic,SMARCA4,UNDEREXPRESSION,Non-small Cell Lung Carcinoma,NA,NA,Non-small Cell Lung Carcinoma,NA,NA,26671993 +Civic,SETBP1,EXON 4 MUTATION,Chronic Myeloid Leukemia,NA,NA,Chronic Myeloid Leukemia,NA,NA,23222956 +Civic,SETBP1,G870S,Chronic Myeloid Leukemia,NA,NA,Chronic Myeloid Leukemia,NA,NA,23222956 +Civic,ALK,EML4-ALK C1156Y,Non-small Cell Lung Carcinoma,NA,NA,Non-small Cell Lung Carcinoma,NA,NA,26698910 +Civic,ALK,EML4-ALK C1156Y,Non-small Cell Lung Carcinoma,NA,NA,Non-small Cell Lung Carcinoma,NA,NA,26698910 +Civic,ALK,EML4-ALK C1156Y–L1198F,Non-small Cell Lung Carcinoma,NA,NA,Non-small Cell Lung Carcinoma,NA,NA,26698910 +Civic,ALK,EML4-ALK C1156Y–L1198F,Non-small Cell Lung Carcinoma,NA,NA,Non-small Cell Lung Carcinoma,NA,NA,26698910 +Civic,BRCA1,LOSS-OF-FUNCTION,Prostate Cancer,NA,NA,Prostate Cancer,NA,NA,26510020 +Civic,AREG,EXPRESSION,Head And Neck Squamous Cell Carcinoma,NA,NA,Head And Neck Squamous Cell Carcinoma,NA,NA,21653686 +Civic,EGFR,VIII,Head And Neck Squamous Cell Carcinoma,NA,NA,Head And Neck Squamous Cell Carcinoma,NA,NA,21653686 +Civic,EGFR,EXPRESSION,Head And Neck Squamous Cell Carcinoma,NA,NA,Head And Neck Squamous Cell Carcinoma,NA,NA,21653686 +Civic,TP53,MUTATION,Gastric Adenocarcinoma,NA,NA,Gastric Adenocarcinoma,NA,NA,24740294 +Civic,TP53,MUTATION,Breast Cancer,NA,NA,Breast Cancer,NA,NA,22698404 +Civic,CDKN1A,EXPRESSION,Colorectal Cancer,NA,NA,Colorectal Cancer,NA,NA,24708484 +Civic,ALCAM,EXPRESSION,Colorectal Cancer,NA,NA,Colorectal Cancer,NA,NA,24708484 +Civic,EGFR,AMPLIFICATION,Colorectal Cancer,NA,NA,Colorectal Cancer,NA,NA,24653627 +Civic,STMN1,EXPRESSION,Endometrial Carcinoma,NA,NA,Endometrial Carcinoma,NA,NA,24587245 +Civic,CCND1,OVEREXPRESSION,Estrogen-receptor Positive Breast Cancer,NA,NA,Estrogen-receptor Positive Breast Cancer,NA,NA,15138475 +Civic,RSF1,AMPLIFICATION,Breast Cancer,NA,NA,Breast Cancer,NA,NA,24367492 +Civic,CCND1,AMPLIFICATION,Breast Cancer,NA,NA,Breast Cancer,NA,NA,24367492 +Civic,AR,OVEREXPRESSION,Breast Cancer,NA,NA,Breast Cancer,NA,NA,24356815 +Civic,CDKN1B,CYTOPLASMIC MISLOCALIZATION,Breast Cancer,NA,NA,Breast Cancer,NA,NA,25587029 +Civic,NRG1,EXPRESSION,Cancer,NA,NA,Cancer,NA,NA,25542901 +Civic,ERBB3,EXPRESSION,Cancer,NA,NA,Cancer,NA,NA,25542901 +Civic,AR,SPLICE VARIANT 7,Prostate Cancer,NA,NA,Prostate Cancer,NA,NA,25184630 +Civic,PTEN,LOSS,Gastric Adenocarcinoma,NA,NA,Gastric Adenocarcinoma,NA,NA,25300346 +Civic,ERBB3,EXPRESSION,Pancreatic Ductal Adenocarcinoma,NA,NA,Pancreatic Ductal Adenocarcinoma,NA,NA,25216528 +Civic,UGT1A,EXPRESSION,Colorectal Cancer,NA,NA,Colorectal Cancer,NA,NA,25210794 +Civic,ERBB4,NUCLEAR TRANSLOCATION,Breast Cancer,NA,NA,Breast Cancer,NA,NA,25153719 +Civic,ERBB4,NUCLEAR TRANSLOCATION,Breast Cancer,NA,NA,Breast Cancer,NA,NA,25153719 +Civic,ERBB4,EXPRESSION,Breast Cancer,NA,NA,Breast Cancer,NA,NA,25590338 +Civic,SLFN11,EXPRESSION,Colorectal Cancer,NA,NA,Colorectal Cancer,NA,NA,25089570 +Civic,AURKA,OVEREXPRESSION,Non-small Cell Lung Carcinoma,NA,NA,Non-small Cell Lung Carcinoma,NA,NA,25082261 +Civic,KRAS,RS61764370,Head And Neck Squamous Cell Carcinoma,NA,NA,Head And Neck Squamous Cell Carcinoma,NA,NA,25081901 +Civic,RAC1,P29S,Melanoma,NA,NA,Melanoma,NA,NA,25056119 +Civic,BIRC5,NUCLEAR EXPRESSION,Non-small Cell Lung Carcinoma,NA,NA,Non-small Cell Lung Carcinoma,NA,NA,24961465 +Civic,TP53,WILD TYPE,Colorectal Cancer,NA,NA,Colorectal Cancer,NA,NA,24957073 +Civic,MRE11,LOSS,Endometrial Cancer,NA,NA,Endometrial Cancer,NA,NA,24927325 +Civic,ATM,UNDEREXPRESSION,Gastric Adenocarcinoma,NA,NA,Gastric Adenocarcinoma,NA,NA,24841718 +Civic,EGFR,L858R,Lung Adenocarcinoma,NA,NA,Lung Adenocarcinoma,NA,NA,23816960 +Civic,EGFR,EXON 19 DELETION,Lung Adenocarcinoma,NA,NA,Lung Adenocarcinoma,NA,NA,23816960 +Civic,EGFR,EXON 19 DELETION,Non-small Cell Lung Carcinoma,NA,NA,Non-small Cell Lung Carcinoma,NA,NA,25862853 +Civic,EGFR,EXON 19 DELETION,Lung Adenocarcinoma,NA,NA,Lung Adenocarcinoma,NA,NA,22452895 +Civic,EGFR,L858R,Lung Adenocarcinoma,NA,NA,Lung Adenocarcinoma,NA,NA,22452895 +Civic,EGFR,EXON 19 DELETION,Non-small Cell Lung Carcinoma,NA,NA,Non-small Cell Lung Carcinoma,NA,NA,22285168 +Civic,EGFR,L858R,Non-small Cell Lung Carcinoma,NA,NA,Non-small Cell Lung Carcinoma,NA,NA,22285168 +Civic,ERBB2,AMPLIFICATION,Uterine Corpus Endometrial Carcinoma,NA,NA,Uterine Corpus Endometrial Carcinoma,NA,NA,25268372 +Civic,ERBB2,AMPLIFICATION,Breast Cancer,NA,NA,Breast Cancer,NA,NA,25537159 +Civic,TOP1,AMPLIFICATION,Colorectal Cancer,NA,NA,Colorectal Cancer,NA,NA,24256029 +Civic,CDKN1B,EXPRESSION,Head And Neck Squamous Cell Carcinoma,NA,NA,Head And Neck Squamous Cell Carcinoma,NA,NA,24239278 +Civic,MET,AMPLIFICATION,Lung Squamous Cell Carcinoma,NA,NA,Lung Squamous Cell Carcinoma,NA,NA,24192513 +Civic,AGR2,EXPRESSION,Breast Cancer,NA,NA,Breast Cancer,NA,NA,24167368 +Civic,PIK3CA,MUTATION,Endometrial Cancer,NA,NA,Endometrial Cancer,NA,NA,24166148 +Civic,PTEN,LOSS,Endometrial Cancer,NA,NA,Endometrial Cancer,NA,NA,24166148 +Civic,KRAS,MUTATION,Endometrial Cancer,NA,NA,Endometrial Cancer,NA,NA,24166148 +Civic,ERBB2,AMPLIFICATION,Colorectal Cancer,NA,NA,Colorectal Cancer,NA,NA,24146218 +Civic,FGFR1,EXPRESSION,Colorectal Cancer,NA,NA,Colorectal Cancer,NA,NA,24135816 +Civic,NAPRT,PROMOTER HYPERMETHYLATION,Cancer,NA,NA,Cancer,NA,NA,24097869 +Civic,EGFR,EXON 18 OVEREXPRESSION,Non-small Cell Lung Carcinoma,NA,NA,Non-small Cell Lung Carcinoma,NA,NA,24039832 +Civic,ZEB1,EXPRESSION,Mantle Cell Lymphoma,NA,NA,Mantle Cell Lymphoma,NA,NA,24013721 +Civic,ZEB1,EXPRESSION,Mantle Cell Lymphoma,NA,NA,Mantle Cell Lymphoma,NA,NA,24013721 +Civic,TIMP1,OVEREXPRESSION,Breast Cancer,NA,NA,Breast Cancer,NA,NA,23881388 +Civic,PTP4A3,OVEREXPRESSION,Colorectal Cancer,NA,NA,Colorectal Cancer,NA,NA,23867504 +Civic,TYMS,AMPLIFICATION,Lung Adenocarcinoma,NA,NA,Lung Adenocarcinoma,NA,NA,23645741 +Civic,IGF1R,EXPRESSION,Non-small Cell Lung Carcinoma,NA,NA,Non-small Cell Lung Carcinoma,NA,NA,23619944 +Civic,EPHB4,EXPRESSION,Colorectal Cancer,NA,NA,Colorectal Cancer,NA,NA,23579861 +Civic,TP53,WILD TYPE,Esophageal Carcinoma,NA,NA,Esophageal Carcinoma,NA,NA,23515910 +Civic,TYMS,UNDEREXPRESSION,Non-small Cell Lung Carcinoma,NA,NA,Non-small Cell Lung Carcinoma,NA,NA,21367480 +Civic,TYMS,UNDEREXPRESSION,Prostate Cancer,NA,NA,Prostate Cancer,NA,NA,24782778 +Civic,TOP2A,EXPRESSION,Breast Cancer,NA,NA,Breast Cancer,NA,NA,15486187 +Civic,TOP1,EXPRESSION,Ovarian Cancer,NA,NA,Ovarian Cancer,NA,NA,19648970 +Civic,EGFR,AMPLIFICATION,Colorectal Cancer,NA,NA,Colorectal Cancer,NA,NA,18794099 +Civic,TOP1,EXPRESSION,Colorectal Cancer,NA,NA,Colorectal Cancer,NA,NA,19775480 +Civic,PRKAA2,T172 PHOSPHORYLATION,Cancer,NA,NA,Cancer,NA,NA,23506848 +Civic,HSPA5,EXPRESSION,Colorectal Cancer,NA,NA,Colorectal Cancer,NA,NA,23456958 +Civic,PIK3CA,MUTATION,Colorectal Cancer,NA,NA,Colorectal Cancer,NA,NA,23435830 +Civic,KRAS,EXON 2 MUTATION,Pancreatic Carcinoma,NA,NA,Pancreatic Carcinoma,NA,NA,23435671 +Civic,KRAS,EXON 2 MUTATION,Pancreatic Carcinoma,NA,NA,Pancreatic Carcinoma,NA,NA,23435671 +Civic,EIF4EBP1,PHOSPHORYLATION,Gastric Adenocarcinoma,NA,NA,Gastric Adenocarcinoma,NA,NA,23340172 +Civic,KIT,MUTATION,Gastrointestinal Stromal Tumor,NA,NA,Gastrointestinal Stromal Tumor,NA,NA,23231951 +Civic,TUBB3,EXPRESSION,Cancer,NA,NA,Cancer,NA,NA,21576762 +Civic,TUBB3,EXPRESSION,Breast Cancer,NA,NA,Breast Cancer,NA,NA,23218766 +Civic,TYMS,EXPRESSION,Non-small Cell Lung Carcinoma,NA,NA,Non-small Cell Lung Carcinoma,NA,NA,23060591 +Civic,EGFR,Y1092 PHOSPHORYLATION,Non-small Cell Lung Carcinoma,NA,NA,Non-small Cell Lung Carcinoma,NA,NA,22901364 +Civic,IGF1R,NUCLEAR EXPRESSION,Sarcoma,NA,NA,Sarcoma,NA,NA,22682017 +Civic,CFLAR,EXPRESSION,Prostate Cancer,NA,NA,Prostate Cancer,NA,NA,22623731 +Civic,PROM1,EXPRESSION,Hepatocellular Carcinoma,NA,NA,Hepatocellular Carcinoma,NA,NA,22596232 +Civic,TIMP1,OVEREXPRESSION,Breast Cancer,NA,NA,Breast Cancer,NA,NA,22544540 +Civic,FOXP3,EXPRESSION,Breast Cancer,NA,NA,Breast Cancer,NA,NA,22431701 +Civic,TYMS,EXPRESSION,Gastric Adenocarcinoma,NA,NA,Gastric Adenocarcinoma,NA,NA,22422354 +Civic,RPS6,PHOSPHORYLATION,Gastric Adenocarcinoma,NA,NA,Gastric Adenocarcinoma,NA,NA,22343617 +Civic,JAK1,OVEREXPRESSION,Non-small Cell Lung Carcinoma,NA,NA,Non-small Cell Lung Carcinoma,NA,NA,22333600 +Civic,EIF4EBP1,PHOSPHORYLATION,Colorectal Cancer,NA,NA,Colorectal Cancer,NA,NA,22262166 +Civic,BRCA1,EXPRESSION,Malignant Mesothelioma,NA,NA,Malignant Mesothelioma,NA,NA,22190288 +Civic,DUSP6,EXPRESSION,Cancer,NA,NA,Cancer,NA,NA,22169769 +Civic,KRAS,MUTATION,Cancer,NA,NA,Cancer,NA,NA,22169769 +Civic,BRAF,MUTATION,Cancer,NA,NA,Cancer,NA,NA,22169769 +Civic,KRAS,G12D,Pancreatic Carcinoma,NA,NA,Pancreatic Carcinoma,NA,NA,22025163 +Civic,PTEN,LOSS,Pancreatic Carcinoma,NA,NA,Pancreatic Carcinoma,NA,NA,22025163 +Civic,HSPB1,EXPRESSION,Pancreatic Ductal Adenocarcinoma,NA,NA,Pancreatic Ductal Adenocarcinoma,NA,NA,22004109 +Civic,NQO1,EXPRESSION,Lung Cancer,NA,NA,Lung Cancer,NA,NA,21964527 +Civic,NQO1,P187S,Lung Cancer,NA,NA,Lung Cancer,NA,NA,21964527 +Civic,BRCA1,UNDEREXPRESSION,Ovarian Cancer,NA,NA,Ovarian Cancer,NA,NA,21920589 +Civic,KRAS,MUTATION,Colorectal Cancer,NA,NA,Colorectal Cancer,NA,NA,21890455 +Civic,ABCB1,EXPRESSION,Non-small Cell Lung Carcinoma,NA,NA,Non-small Cell Lung Carcinoma,NA,NA,21883677 +Civic,ALK,ALK FUSIONS,Non-small Cell Lung Carcinoma,NA,NA,Non-small Cell Lung Carcinoma,NA,NA,21642865 +Civic,DNMT1,EXPRESSION,Gastric Adenocarcinoma,NA,NA,Gastric Adenocarcinoma,NA,NA,21458988 +Civic,KRAS,MUTATION,Colorectal Cancer,NA,NA,Colorectal Cancer,NA,NA,20956938 +Civic,EGFR,AMPLIFICATION,Non-small Cell Lung Carcinoma,NA,NA,Non-small Cell Lung Carcinoma,NA,NA,20826716 +Civic,CXCR4,EXPRESSION,Gastric Adenocarcinoma,NA,NA,Gastric Adenocarcinoma,NA,NA,20651371 +Civic,MAGEH1,EXPRESSION,Bile Duct Adenocarcinoma,NA,NA,Bile Duct Adenocarcinoma,NA,NA,20088962 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Cancer,NA,NA,22418700 +Civic,ERBB2,AMPLIFICATION,Pancreatic Adenocarcinoma,NA,NA,Pancreatic Adenocarcinoma,NA,NA,26668065 +Civic,EGFR,T790M,Non-small Cell Lung Carcinoma,NA,NA,Non-small Cell Lung Carcinoma,NA,NA,24893891 +Civic,EGFR,C797S,Non-small Cell Lung Carcinoma,NA,NA,Non-small Cell Lung Carcinoma,NA,NA,25939061 +Civic,EGFR,T790M,Non-small Cell Lung Carcinoma,NA,NA,Non-small Cell Lung Carcinoma,NA,NA,25923549 +Civic,EGFR,T790M,Non-small Cell Lung Carcinoma,NA,NA,Non-small Cell Lung Carcinoma,NA,NA,26720284 +Civic,EGFR,T790M,Non-small Cell Lung Carcinoma,NA,NA,Non-small Cell Lung Carcinoma,NA,NA,26515464 +Civic,EGFR,L858R,Non-small Cell Lung Carcinoma,NA,NA,Non-small Cell Lung Carcinoma,NA,NA,26515464 +Civic,EGFR,EXON 19 DELETION,Non-small Cell Lung Carcinoma,NA,NA,Non-small Cell Lung Carcinoma,NA,NA,26515464 +Civic,FGFR1,EXPRESSION,Head And Neck Squamous Cell Carcinoma,NA,NA,Head And Neck Squamous Cell Carcinoma,NA,NA,16454808 +Civic,EGFR,VIII,Glioblastoma 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Adenocarcinoma,NA,NA,Lung Adenocarcinoma,NA,NA,16906227 +Civic,CD274,EXPRESSION,Non-small Cell Lung Carcinoma,NA,NA,Non-small Cell Lung Carcinoma,NA,NA,26970723 +Civic,KRAS,G12C,Cancer,NA,NA,Cancer,NA,NA,26739882 +Civic,ERBB2,V842I,Colon Cancer,NA,NA,Colon Cancer,NA,NA,26243863 +Civic,ALK,ALK FUSIONS,Non-small Cell Lung Carcinoma,NA,NA,Non-small Cell Lung Carcinoma,NA,NA,26973324 +Civic,ERBB2,L755S,Colon Cancer,NA,NA,Colon Cancer,NA,NA,26243863 +Civic,ERBB2,V777L,Colon Cancer,NA,NA,Colon Cancer,NA,NA,26243863 +Civic,ERBB2,L866M,Colon Cancer,NA,NA,Colon Cancer,NA,NA,26243863 +Civic,ERBB2,S310F/Y,Colon Cancer,NA,NA,Colon Cancer,NA,NA,26243863 +Civic,KRAS,G13D,Colorectal Cancer,NA,NA,Colorectal Cancer,NA,NA,26371285 +Civic,KRAS,G13D,Colorectal Cancer,NA,NA,Colorectal Cancer,NA,NA,26812186 +Civic,KRAS,MUTATION,Colorectal Cancer,NA,NA,Colorectal Cancer,NA,NA,26709701 +Civic,KRAS,MUTATION,Cancer,NA,NA,Cancer,NA,NA,26881434 +Civic,MIR218-1,UNDEREXPRESSION,Pancreatic Cancer,NA,NA,Pancreatic Cancer,NA,NA,26662432 +Civic,MET,EXON 14 SKIPPING MUTATION,Lung Adenocarcinoma,NA,NA,Lung Adenocarcinoma,NA,NA,26729443 +Civic,MET,EXON 14 SKIPPING MUTATION,Lung Adenocarcinoma,NA,NA,Lung Adenocarcinoma,NA,NA,25971938 +Civic,ALK,ALK FUSIONS,Non-small Cell Lung Carcinoma,NA,NA,Non-small Cell Lung Carcinoma,NA,NA,20979469 +Civic,ALK,EML4-ALK,Non-small Cell Lung Carcinoma,NA,NA,Non-small Cell Lung Carcinoma,NA,NA,17625570 +Civic,ALK,EML4-ALK E20;A20,Non-small Cell Lung Carcinoma,NA,NA,Non-small Cell Lung Carcinoma,NA,NA,20979469 +Civic,ALK,EML4-ALK E2;A20,Non-small Cell Lung Carcinoma,NA,NA,Non-small Cell Lung Carcinoma,NA,NA,18927303 +Civic,KDR,R961W,Colorectal Adenocarcinoma,NA,NA,Colorectal Adenocarcinoma,NA,NA,27004155 +Civic,ALK,EML4-ALK E6;A20,Non-small Cell Lung Carcinoma,NA,NA,Non-small Cell Lung Carcinoma,NA,NA,18593892 +Civic,ALK,EML4-ALK E6;A20,Non-small Cell Lung Carcinoma,NA,NA,Non-small Cell Lung Carcinoma,NA,NA,20979469 +Civic,ALK,EML4-ALK E6;A20,Non-small Cell Lung Carcinoma,NA,NA,Non-small Cell Lung Carcinoma,NA,NA,18451166 +Civic,ALK,EML4-ALK E6;A20,Non-small Cell Lung Carcinoma,NA,NA,Non-small Cell Lung Carcinoma,NA,NA,18594010 +Civic,ALK,EML4-ALK E20;A20,Non-small Cell Lung Carcinoma,NA,NA,Non-small Cell Lung Carcinoma,NA,NA,22912387 +Civic,ALK,EML4-ALK E6;A20,Non-small Cell Lung Carcinoma,NA,NA,Non-small Cell Lung Carcinoma,NA,NA,22912387 +Civic,ALK,ALK FUSIONS,Non-small Cell Lung Carcinoma,NA,NA,Non-small Cell Lung Carcinoma,NA,NA,23724913 +Civic,ALK,ALK FUSIONS,Non-small Cell Lung Carcinoma,NA,NA,Non-small Cell Lung Carcinoma,NA,NA,25470694 +Civic,ALK,ALK FUSIONS,Non-small Cell Lung Carcinoma,NA,NA,Non-small Cell Lung Carcinoma,NA,NA,24478318 +Civic,ALK,ALK FUSIONS,Non-small Cell Lung Carcinoma,NA,NA,Non-small Cell Lung Carcinoma,NA,NA,27022118 +Civic,ALK,ALK FUSIONS,Non-small Cell Lung Carcinoma,NA,NA,Non-small Cell Lung Carcinoma,NA,NA,20940188 +Civic,ALK,EML4-ALK,Non-small Cell Lung Carcinoma,NA,NA,Non-small Cell Lung Carcinoma,NA,NA,21258415 +Civic,ALK,EML4-ALK E20;A20,Non-small Cell Lung Carcinoma,NA,NA,Non-small Cell Lung Carcinoma,NA,NA,22912387 +Civic,ALK,EML4-ALK E6;A20,Non-small Cell Lung Carcinoma,NA,NA,Non-small Cell Lung Carcinoma,NA,NA,22912387 +Civic,ALK,EML4-ALK,Non-small Cell Lung Carcinoma,NA,NA,Non-small Cell Lung Carcinoma,NA,NA,22912387 +Civic,ALK,EML4-ALK,Non-small Cell Lung Carcinoma,NA,NA,Non-small Cell Lung Carcinoma,NA,NA,20979469 +Civic,KRAS,EXON 2 MUTATION,Colorectal Cancer,NA,NA,Colorectal Cancer,NA,NA,27037411 +Civic,TP53,P47S,Cancer,NA,NA,Cancer,NA,NA,27034505 +Civic,GNAQ,MUTATION,Uveal Melanoma,NA,NA,Uveal Melanoma,NA,NA,26397223 +Civic,GNA11,MUTATION,Uveal Melanoma,NA,NA,Uveal Melanoma,NA,NA,26397223 +Civic,GNA11,Q209,Uveal Melanoma,NA,NA,Uveal Melanoma,NA,NA,24938562 +Civic,GNAQ,Q209,Uveal Melanoma,NA,NA,Uveal Melanoma,NA,NA,24938562 +Civic,PMS2,K706FS*19,Glioblastoma Multiforme,NA,NA,Glioblastoma Multiforme,NA,NA,27001570 +Civic,KRAS,G12D,Colorectal Cancer,NA,NA,Colorectal Cancer,NA,NA,22948721 +Civic,KRAS,G12C,Colorectal Cancer,NA,NA,Colorectal Cancer,NA,NA,23313110 +Civic,KRAS,G12C,Non-small Cell Lung Carcinoma,NA,NA,Non-small Cell Lung Carcinoma,NA,NA,22247021 +Civic,KRAS,MUTATION,Lung Adenocarcinoma,NA,NA,Lung Adenocarcinoma,NA,NA,21847063 +Civic,KRAS,EXON 2 MUTATION,Pancreatic Cancer,NA,NA,Pancreatic Cancer,NA,NA,21862683 +Civic,KRAS,MUTATION,Non-small Cell Lung Carcinoma,NA,NA,Non-small Cell Lung Carcinoma,NA,NA,22805291 +Civic,KIT,EXON 9 MUTATION,Gastrointestinal Stromal Tumor,NA,NA,Gastrointestinal Stromal Tumor,NA,NA,16624552 +Civic,KIT,MUTATION,Melanoma,NA,NA,Melanoma,NA,NA,21690468 +Civic,KIT,EXON 9 MUTATION,Gastrointestinal Stromal Tumor,NA,NA,Gastrointestinal Stromal Tumor,NA,NA,22439647 +Civic,KIT,EXON 11 MUTATION,Melanoma,NA,NA,Melanoma,NA,NA,22261812 +Civic,NRAS,MUTATION,Skin Melanoma,NA,NA,Skin Melanoma,NA,NA,25542057 +Civic,NRAS,Q61,Skin Melanoma,NA,NA,Skin Melanoma,NA,NA,23414587 +Civic,NRAS,MUTATION,Melanoma,NA,NA,Melanoma,NA,NA,22805292 +Civic,GNA11,MUTATION,Uveal Melanoma,NA,NA,Uveal Melanoma,NA,NA,22805292 +Civic,GNAQ,MUTATION,Uveal Melanoma,NA,NA,Uveal Melanoma,NA,NA,22805292 +Civic,NRAS,MUTATION,Cancer,NA,NA,Cancer,NA,NA,25504439 +Civic,PTEN,DELETION,Prostate Cancer,NA,NA,Prostate Cancer,NA,NA,23582881 +Civic,PTEN,MUTATION,Endometrial Carcinoma,NA,NA,Endometrial Carcinoma,NA,NA,23238879 +Civic,GNAQ,Q209,Uveal Melanoma,NA,NA,Uveal Melanoma,NA,NA,23434733 +Civic,BAP1,MUTATION,Uveal Melanoma,NA,NA,Uveal Melanoma,NA,NA,22038994 +Civic,BAP1,MUTATION,Malignant Mesothelioma,NA,NA,Malignant Mesothelioma,NA,NA,25970771 +Civic,FGFR2,MUTATION,Endometrial Cancer,NA,NA,Endometrial Cancer,NA,NA,26574622 +Civic,ALK,MUTATION,Non-small Cell Lung Carcinoma,NA,NA,Non-small Cell Lung Carcinoma,NA,NA,24670165 +Civic,DNMT3A,MUTATION,Myelodysplastic Syndrome,NA,NA,Myelodysplastic Syndrome,NA,NA,21415852 +Civic,ALK,NPM-ALK,Anaplastic Large Cell Lymphoma,NA,NA,Anaplastic Large Cell Lymphoma,NA,NA,18089725 +Civic,ALK,ALK FUSIONS,Anaplastic Large Cell Lymphoma,NA,NA,Anaplastic Large Cell Lymphoma,NA,NA,21345110 +Civic,ALK,NPM-ALK,Anaplastic Large Cell Lymphoma,NA,NA,Anaplastic Large Cell Lymphoma,NA,NA,23598171 +Civic,ALK,ALK FUSIONS,Inflammatory Myofibroblastic Tumor,NA,NA,Inflammatory Myofibroblastic Tumor,NA,NA,23598171 +Civic,ALK,RANBP2-ALK,Inflammatory Myofibroblastic Tumor,NA,NA,Inflammatory Myofibroblastic Tumor,NA,NA,20979472 +Civic,ALK,EML4-ALK E20;A20,Cancer,NA,NA,Cancer,NA,NA,25408655 +Civic,FGFR1,N546K,Bone Ewing's Sarcoma,NA,NA,Bone Ewing's Sarcoma,NA,NA,26179511 +Civic,FGFR1,AMPLIFICATION,Bone Ewing's Sarcoma,NA,NA,Bone Ewing's Sarcoma,NA,NA,26179511 +Civic,ROS1,REARRANGEMENT,Lung Adenocarcinoma,NA,NA,Lung Adenocarcinoma,NA,NA,26917690 +Civic,ROS1,CD74-ROS1 G2032R,Non-small Cell Lung Carcinoma,NA,NA,Non-small Cell Lung Carcinoma,NA,NA,26372962 +Civic,ROS1,CD74-ROS1 G2032R,Non-small Cell Lung Carcinoma,NA,NA,Non-small Cell Lung Carcinoma,NA,NA,26372962 +Civic,ROS1,CD74-ROS1 G2032R,Non-small Cell Lung Carcinoma,NA,NA,Non-small Cell Lung Carcinoma,NA,NA,25733882 +Civic,ROS1,CD74-ROS1 L2026M,Non-small Cell Lung Carcinoma,NA,NA,Non-small Cell Lung Carcinoma,NA,NA,25733882 +Civic,ROS1,CD74-ROS1 L2026M,Non-small Cell Lung Carcinoma,NA,NA,Non-small Cell Lung Carcinoma,NA,NA,25733882 +Civic,ROS1,CD74-ROS1 G2032R,Non-small Cell Lung Carcinoma,NA,NA,Non-small Cell Lung Carcinoma,NA,NA,25688157 +Civic,ROS1,CD74-ROS1 G2032R,Non-small Cell Lung Carcinoma,NA,NA,Non-small Cell Lung Carcinoma,NA,NA,25688157 +Civic,ROS1,CD74-ROS1 L2155S,Non-small Cell Lung Carcinoma,NA,NA,Non-small Cell Lung Carcinoma,NA,NA,25688157 +Civic,ROS1,CD74-ROS1 L2026M,Non-small Cell Lung Carcinoma,NA,NA,Non-small Cell Lung Carcinoma,NA,NA,25688157 +Civic,ROS1,CD74-ROS1 L2026M,Non-small Cell Lung Carcinoma,NA,NA,Non-small Cell Lung Carcinoma,NA,NA,25688157 +Civic,ROS1,CD74-ROS1 G2101A,Non-small Cell Lung Carcinoma,NA,NA,Non-small Cell Lung Carcinoma,NA,NA,25688157 +Civic,ROS1,CD74-ROS1 G2101A,Non-small Cell Lung Carcinoma,NA,NA,Non-small Cell Lung Carcinoma,NA,NA,25688157 +Civic,ALK,CLTC-ALK,Diffuse Large B-cell Lymphoma,NA,NA,Diffuse Large B-cell Lymphoma,NA,NA,21494621 +Civic,U2AF1,MUTATION,Myelofibrosis,NA,NA,Myelofibrosis,NA,NA,27058230 +Civic,ALK,CLTC-ALK,Diffuse Large B-cell Lymphoma,NA,NA,Diffuse Large B-cell Lymphoma,NA,NA,19636007 +Civic,ALK,ALK FUSIONS,Diffuse Large B-cell Lymphoma,NA,NA,Diffuse Large B-cell Lymphoma,NA,NA,24330038 +Civic,ALK,CLTC-ALK,Diffuse Large B-cell Lymphoma,NA,NA,Diffuse Large B-cell Lymphoma,NA,NA,26221234 +Civic,ALK,EML4-ALK E2;A20,Renal Cell Carcinoma,NA,NA,Renal Cell Carcinoma,NA,NA,22252991 +Civic,BRAF,DEL 485-490,Cancer,NA,NA,Cancer,NA,NA,26732095 +Civic,ALK,R1275Q,Neuroblastoma,NA,NA,Neuroblastoma,NA,NA,23598171 +Civic,ALK,R1275Q,Neuroblastoma,NA,NA,Neuroblastoma,NA,NA,23598171 +Civic,ALK,F1174L,Neuroblastoma,NA,NA,Neuroblastoma,NA,NA,23598171 +Civic,ALK,ALK FUSIONS,Non-small Cell Lung Carcinoma,NA,NA,Non-small Cell Lung Carcinoma,NA,NA,23639470 +Civic,ALK,ALK FUSIONS,Non-small Cell Lung Carcinoma,NA,NA,Non-small Cell Lung Carcinoma,NA,NA,26938871 +Civic,CD274,EXPRESSION,Papillary Thyroid Carcinoma,NA,NA,Papillary Thyroid Carcinoma,NA,NA,27086918 +Civic,CD274,EXPRESSION,Stomach Carcinoma,NA,NA,Stomach Carcinoma,NA,NA,27009855 +Civic,DUX4,DUX4 FUSIONS,Acute Lymphocytic Leukemia,NA,NA,Acute Lymphocytic Leukemia,NA,NA,27019113 +Civic,DUX4,DUX4 FUSIONS,Acute Lymphocytic Leukemia,NA,NA,Acute Lymphocytic Leukemia,NA,NA,27019113 +Civic,B4GALT1,EXPRESSION,Renal Cell Carcinoma,NA,NA,Renal Cell Carcinoma,NA,NA,27092876 +Civic,ALK,ALK FUSIONS,Non-small Cell Lung Carcinoma,NA,NA,Non-small Cell Lung Carcinoma,NA,NA,25153538 +Civic,BCL2L11,DELETION POLYMORPHISM,Chronic Myeloid Leukemia,NA,NA,Chronic Myeloid Leukemia,NA,NA,22426421 +Civic,BCL2L11,DELETION POLYMORPHISM,Non-small Cell Lung Carcinoma,NA,NA,Non-small Cell Lung Carcinoma,NA,NA,22426421 +Civic,ALK,ALK FUSIONS,Non-small Cell Lung Carcinoma,NA,NA,Non-small Cell Lung Carcinoma,NA,NA,26708155 +Civic,ALK,ALK FUSION I1171,Non-small Cell Lung Carcinoma,NA,NA,Non-small Cell Lung Carcinoma,NA,NA,25228534 +Civic,ALK,ALK FUSION I1171,Non-small Cell Lung Carcinoma,NA,NA,Non-small Cell Lung Carcinoma,NA,NA,25228534 +Civic,ALK,ALK FUSION I1171,Non-small Cell Lung Carcinoma,NA,NA,Non-small Cell Lung Carcinoma,NA,NA,25228534 +Civic,ALK,EML4-ALK V1180L,Non-small Cell Lung Carcinoma,NA,NA,Non-small Cell Lung Carcinoma,NA,NA,25228534 +Civic,ALK,ALK FUSION I1171,Non-small Cell Lung Carcinoma,NA,NA,Non-small Cell Lung Carcinoma,NA,NA,25228534 +Civic,ALK,EML4-ALK V1180L,Non-small Cell Lung Carcinoma,NA,NA,Non-small Cell Lung Carcinoma,NA,NA,25228534 +Civic,ALK,EML4-ALK V1180L,Non-small Cell Lung Carcinoma,NA,NA,Non-small Cell Lung Carcinoma,NA,NA,25228534 +Civic,ALK,EML4-ALK V1180L,Non-small Cell Lung Carcinoma,NA,NA,Non-small Cell Lung Carcinoma,NA,NA,25228534 +Civic,ALK,EML4-ALK V1180L,Non-small Cell Lung Carcinoma,NA,NA,Non-small Cell Lung Carcinoma,NA,NA,25228534 +Civic,ATM,UNDEREXPRESSION,Pancreatic Cancer,NA,NA,Pancreatic Cancer,NA,NA,25423555 +Civic,SIRT1,OVEREXPRESSION,Pancreatic Ductal Carcinoma,NA,NA,Pancreatic Ductal Carcinoma,NA,NA,24088390 +Civic,SIRT1,OVEREXPRESSION,Pancreatic Cancer,NA,NA,Pancreatic Cancer,NA,NA,24088390 +Civic,FLT3,TKD MUTATION,Acute Myeloid Leukemia,NA,NA,Acute Myeloid Leukemia,NA,NA,20733134 +Civic,PIK3CA,MUTATION,Her2-receptor Positive Breast Cancer,NA,NA,Her2-receptor Positive Breast Cancer,NA,NA,27091708 +Civic,PTEN,LOSS,Her2-receptor Positive Breast Cancer,NA,NA,Her2-receptor Positive Breast Cancer,NA,NA,27091708 +Civic,KRAS,G12R,Pancreatic Cancer,NA,NA,Pancreatic Cancer,NA,NA,22983505 +Civic,KRAS,G12D,Pancreatic Cancer,NA,NA,Pancreatic Cancer,NA,NA,27010960 +Civic,ROS1,REARRANGEMENT,Colorectal Adenocarcinoma,NA,NA,Colorectal Adenocarcinoma,NA,NA,24296758 +Civic,TP53,P72R,Breast Cancer,NA,NA,Breast Cancer,NA,NA,17909070 +Civic,TP53,P72R,Lung Carcinoma,NA,NA,Lung Carcinoma,NA,NA,12840112 +Civic,TP53,P72R,Cervical Cancer,NA,NA,Cervical Cancer,NA,NA,11535556 +Civic,PALB2,BIALLELIC INACTIVATION,Pancreatic Cancer,NA,NA,Pancreatic Cancer,NA,NA,21135251 +Civic,SMAD4,EXPRESSION,Pancreatic Ductal Adenocarcinoma,NA,NA,Pancreatic Ductal Adenocarcinoma,NA,NA,11751510 +Civic,FANCC,LOSS-OF-FUNCTION,Pancreatic Cancer,NA,NA,Pancreatic Cancer,NA,NA,16243825 +Civic,BRCA2,LOSS-OF-FUNCTION,Pancreatic Cancer,NA,NA,Pancreatic Cancer,NA,NA,16243825 +Civic,PDGFRA,I843DEL,Gastrointestinal Stromal Tumor,NA,NA,Gastrointestinal Stromal Tumor,NA,NA,14645423 +Civic,PDGFRB,EBF1-PDGFRB,Acute Lymphocytic Leukemia,NA,NA,Acute Lymphocytic Leukemia,NA,NA,23835704 +Civic,KRAS,G12D,Tumor Of Exocrine Pancreas,NA,NA,Tumor Of Exocrine Pancreas,NA,NA,23565280 +Civic,RB1,EXPRESSION,Non-small Cell Lung Carcinoma,NA,NA,Non-small Cell Lung Carcinoma,NA,NA,22619677 +Civic,CDKN2A,p16 EXPRESSION,Non-small Cell Lung Carcinoma,NA,NA,Non-small Cell Lung Carcinoma,NA,NA,22619677 +Civic,MLH1,METHYLATION,Stomach Carcinoma,NA,NA,Stomach Carcinoma,NA,NA,24748501 +Civic,PTPN11,EXPRESSION,Laryngeal Carcinoma,NA,NA,Laryngeal Carcinoma,NA,NA,24297342 +Civic,FLT3,T227M,Renal Cell Carcinoma,NA,NA,Renal Cell Carcinoma,NA,NA,19667267 +Civic,PALB2,L531FS*30,Breast Cancer,NA,NA,Breast Cancer,NA,NA,18628482 +Civic,MTOR,S2215Y,Endometrial Adenocarcinoma,NA,NA,Endometrial Adenocarcinoma,NA,NA,24631838 +Civic,MTOR,C1483Y,T-cell Acute Lymphoblastic Leukemia,NA,NA,T-cell Acute Lymphoblastic Leukemia,NA,NA,24631838 +Civic,MTOR,E1799K,Renal Clear Cell Carcinoma,NA,NA,Renal Clear Cell Carcinoma,NA,NA,24631838 +Civic,FGFR2,N550K,Endometrial Cancer,NA,NA,Endometrial Cancer,NA,NA,18757403 +Civic,RB1,OVEREXPRESSION,Pancreatic Adenocarcinoma,NA,NA,Pancreatic Adenocarcinoma,NA,NA,11792751 +Civic,PPP1R15A,RS557806,Colorectal Cancer,NA,NA,Colorectal Cancer,NA,NA,27177629 +Civic,KRAS,EXON 2 MUTATION,Colorectal Cancer,NA,NA,Colorectal Cancer,NA,NA,25322874 +Civic,ALK,F1174L,Neuroblastoma,NA,NA,Neuroblastoma,NA,NA,26786851 +Civic,MYCN,AMPLIFICATION,Neuroblastoma,NA,NA,Neuroblastoma,NA,NA,25517749 +Civic,ALK,F1174L,Neuroblastoma,NA,NA,Neuroblastoma,NA,NA,26554404 +Civic,ALK,F1245C,Neuroblastoma,NA,NA,Neuroblastoma,NA,NA,26554404 +Civic,ALK,R1275Q,Neuroblastoma,NA,NA,Neuroblastoma,NA,NA,26554404 +Civic,ALK,EML4-ALK,Non-small Cell Lung Carcinoma,NA,NA,Non-small Cell Lung Carcinoma,NA,NA,26554404 +Civic,ALK,F1245C,Neuroblastoma,NA,NA,Neuroblastoma,NA,NA,23598171 +Civic,ALK,ALK FUSIONS,Colorectal Adenocarcinoma,NA,NA,Colorectal Adenocarcinoma,NA,NA,19737969 +Civic,ALK,ALK FUSIONS,Breast Cancer,NA,NA,Breast Cancer,NA,NA,19737969 +Civic,ALK,DEL4-11,Neuroblastoma,NA,NA,Neuroblastoma,NA,NA,27049722 +Civic,ALK,ALK FUSION F1245C,Cancer,NA,NA,Cancer,NA,NA,22034911 +Civic,ALK,ALK FUSION F1245C,Non-small Cell Lung Carcinoma,NA,NA,Non-small Cell Lung Carcinoma,NA,NA,26775591 +Civic,ALK,ALK FUSION F1245C,Non-small Cell Lung Carcinoma,NA,NA,Non-small Cell Lung Carcinoma,NA,NA,26775591 +Civic,ALK,EML4-ALK E6;A20,Non-small Cell Lung Carcinoma,NA,NA,Non-small Cell Lung Carcinoma,NA,NA,24675041 +Civic,ALK,EML4-ALK L1196M,Non-small Cell Lung Carcinoma,NA,NA,Non-small Cell Lung Carcinoma,NA,NA,24675041 +Civic,ALK,ALK FUSION G1269A,Non-small Cell Lung Carcinoma,NA,NA,Non-small Cell Lung Carcinoma,NA,NA,24675041 +Civic,ALK,EML4-ALK S1206Y,Cancer,NA,NA,Cancer,NA,NA,24675041 +Civic,ALK,ALK FUSION I1171,Non-small Cell Lung Carcinoma,NA,NA,Non-small Cell Lung Carcinoma,NA,NA,24675041 +Civic,ALK,ALK FUSION G1202R,Non-small Cell Lung Carcinoma,NA,NA,Non-small Cell Lung Carcinoma,NA,NA,24675041 +Civic,ALK,EML4-ALK C1156Y,Non-small Cell Lung Carcinoma,NA,NA,Non-small Cell Lung Carcinoma,NA,NA,24675041 +Civic,ALK,EML4-ALK T1151INST,Non-small Cell Lung Carcinoma,NA,NA,Non-small Cell Lung Carcinoma,NA,NA,22277784 +Civic,ALK,EML4-ALK T1151INST,Non-small Cell Lung Carcinoma,NA,NA,Non-small Cell Lung Carcinoma,NA,NA,22277784 +Civic,ALK,EML4-ALK T1151INST,Non-small Cell Lung Carcinoma,NA,NA,Non-small Cell Lung Carcinoma,NA,NA,22277784 +Civic,ALK,ALK FUSION G1202R,Cancer,NA,NA,Cancer,NA,NA,25727400 +Civic,ALK,ALK FUSION G1202R,Cancer,NA,NA,Cancer,NA,NA,25727400 +Civic,ALK,ALK FUSION G1202R,Non-small Cell Lung Carcinoma,NA,NA,Non-small Cell Lung Carcinoma,NA,NA,22277784 +Civic,ALK,ALK FUSION G1269A,Cancer,NA,NA,Cancer,NA,NA,25727400 +Civic,ALK,ALK FUSION G1269A,Cancer,NA,NA,Cancer,NA,NA,25727400 +Civic,ALK,ALK FUSION G1269A,Cancer,NA,NA,Cancer,NA,NA,25727400 +Civic,ALK,NPM-ALK,Cancer,NA,NA,Cancer,NA,NA,25727400 +Civic,ALK,ALK FUSION G1202R,Lung Adenocarcinoma,NA,NA,Lung Adenocarcinoma,NA,NA,22277784 +Civic,PIK3CA,MUTATION,Cancer,NA,NA,Cancer,NA,NA,25855885 +Civic,PTEN,MUTATION,Head And Neck Cancer,NA,NA,Head And Neck Cancer,NA,NA,25855885 +Civic,PIK3CA,MUTATION,Head And Neck Cancer,NA,NA,Head And Neck Cancer,NA,NA,23619167 +Civic,PIK3CA,H1047R,Head And Neck Cancer,NA,NA,Head And Neck Cancer,NA,NA,25855885 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Cancer,NA,NA,Thyroid Cancer,NA,NA,19706758 +Civic,FBXW7,LOSS-OF-FUNCTION,Renal Cell Carcinoma,NA,NA,Renal Cell Carcinoma,NA,NA,24253377 +Civic,CCNE1,AMPLIFICATION,Estrogen-receptor Positive Breast Cancer,NA,NA,Estrogen-receptor Positive Breast Cancer,NA,NA,27020857 +Civic,RB1,M695FS*26,Estrogen-receptor Positive Breast Cancer,NA,NA,Estrogen-receptor Positive Breast Cancer,NA,NA,27020857 +Civic,FBXW7,MUTATION,Cancer,NA,NA,Cancer,NA,NA,24586741 +Civic,FBXW7,LOSS-OF-FUNCTION,Cancer,NA,NA,Cancer,NA,NA,18787170 +Civic,JUN,OVEREXPRESSION,Colorectal Adenocarcinoma,NA,NA,Colorectal Adenocarcinoma,NA,NA,27022066 +Civic,FOS,OVEREXPRESSION,Colon Adenocarcinoma,NA,NA,Colon Adenocarcinoma,NA,NA,27022066 +Civic,CDKN2A,RS3814960,Esophagus Squamous Cell Carcinoma,NA,NA,Esophagus Squamous Cell Carcinoma,NA,NA,27414035 +Civic,MDM2,RS34886328,Esophagus Squamous Cell Carcinoma,NA,NA,Esophagus Squamous Cell Carcinoma,NA,NA,27414035 +Civic,CBLB,RS2305035,Non-small Cell Lung Carcinoma,NA,NA,Non-small Cell 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T674I,"Myeloid And Lymphoid Neoplasms With Eosinophilia And Abnormalities Of PDGFRA, PDGFRB, And FGFR1",NA,NA,"Myeloid And Lymphoid Neoplasms With Eosinophilia And Abnormalities Of PDGFRA, PDGFRB, And FGFR1",NA,NA,24407160 +Civic,EGFR,G719,Lung Adenocarcinoma,NA,NA,Lung Adenocarcinoma,NA,NA,26773740 +Civic,BRD4,BRD4-NUTM1,NUT Midline Carcinoma,NA,NA,NUT Midline Carcinoma,NA,NA,20871596 +Civic,EGFR,S720,Lung Adenocarcinoma,NA,NA,Lung Adenocarcinoma,NA,NA,26773740 +Civic,ALK,ALK FUSIONS,Inflammatory Myofibroblastic Tumor,NA,NA,Inflammatory Myofibroblastic Tumor,NA,NA,10383129 +Civic,CYP2D6,LOSS-OF-FUNCTION,Breast Cancer,NA,NA,Breast Cancer,NA,NA,24098545 +Civic,DDIT3,FUS-DDIT3,Myxoid Liposarcoma,NA,NA,Myxoid Liposarcoma,NA,NA,1568170 +Civic,EGFR,K757R,Lung Adenocarcinoma,NA,NA,Lung Adenocarcinoma,NA,NA,26773740 +Civic,EGFR,E746G,Lung Adenocarcinoma,NA,NA,Lung Adenocarcinoma,NA,NA,26773740 +Civic,MLH1,E13FS*3,Lynch Syndrome,NA,NA,Lynch Syndrome,NA,NA,25111426 +Civic,MSH2,R383*,Lynch Syndrome,NA,NA,Lynch Syndrome,NA,NA,25111426 +Civic,UGT1A1,UGT1A1*28,Cancer,NA,NA,Cancer,NA,NA,26313268 +Civic,MLH1,G606FS*2,Lynch Syndrome,NA,NA,Lynch Syndrome,NA,NA,25111426 +Civic,MLH1,790+1G > A,Lynch Syndrome,NA,NA,Lynch Syndrome,NA,NA,25111426 +Civic,UGT1A1,UGT1A1*60,Cancer,NA,NA,Cancer,NA,NA,26313268 +Civic,MLH1,K618DEL,Lynch Syndrome,NA,NA,Lynch Syndrome,NA,NA,25111426 +Civic,MLH1,R687FS,Lynch Syndrome,NA,NA,Lynch Syndrome,NA,NA,25111426 +Civic,EGFR,V769_770insASV,Lung Adenocarcinoma,NA,NA,Lung Adenocarcinoma,NA,NA,26773740 +Civic,DPYD,DPYD*2A HOMOZYGOSITY,Cancer,NA,NA,Cancer,NA,NA,23988873 +Civic,DPYD,DPYD*13 HOMOZYGOSITY,Cancer,NA,NA,Cancer,NA,NA,23988873 +Civic,FOS,FOS TRUNCATING FUSION,Bone Epithelioid Hemangioma,NA,NA,Bone Epithelioid Hemangioma,NA,NA,26173738 +Civic,DPYD,RS67376798 HOMOZYGOSITY,Cancer,NA,NA,Cancer,NA,NA,23988873 +Civic,MLH1,R100*,Lynch Syndrome,NA,NA,Lynch Syndrome,NA,NA,25111426 +Civic,WWTR1,WWTR1-CAMTA1,Epithelioid Hemangioendothelioma,NA,NA,Epithelioid 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Protuberans,NA,NA,25852058 +Civic,RUNX1,T148HFSX9,Acute Myeloid Leukemia,NA,NA,Acute Myeloid Leukemia,NA,NA,18478040 +Civic,DDX41,R164W,Hematologic Cancer,NA,NA,Hematologic Cancer,NA,NA,26712909 +Civic,ERBB2,Y772_A775DUP,Lung Adenocarcinoma,NA,NA,Lung Adenocarcinoma,NA,NA,22325357 +Civic,ERBB2,G776L,Lung Adenocarcinoma,NA,NA,Lung Adenocarcinoma,NA,NA,22325357 +Civic,ERBB2,G778_P780DUP,Lung Adenocarcinoma,NA,NA,Lung Adenocarcinoma,NA,NA,22325357 +Civic,ERBB2,AMPLIFICATION,Non-small Cell Lung Carcinoma,NA,NA,Non-small Cell Lung Carcinoma,NA,NA,25899785 +Civic,ERBB2,G778_P780DUP,Non-small Cell Lung Carcinoma,NA,NA,Non-small Cell Lung Carcinoma,NA,NA,25899785 +Civic,ERBB2,Y772_A775DUP,Non-small Cell Lung Carcinoma,NA,NA,Non-small Cell Lung Carcinoma,NA,NA,25899785 +Civic,ERBB2,M774DELINSWLV,Non-small Cell Lung Carcinoma,NA,NA,Non-small Cell Lung Carcinoma,NA,NA,25899785 +Civic,PTPRB,LOSS-OF-FUNCTION,Angiosarcoma,NA,NA,Angiosarcoma,NA,NA,24633157 +Civic,VHL,A149S (c.445G>T),Von 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(c.1-1_20del21),Von Hippel-Lindau Disease,NA,NA,Von Hippel-Lindau Disease,NA,NA,15932632 +Civic,VHL,M1? (c.3G>A),Von Hippel-Lindau Disease,NA,NA,Von Hippel-Lindau Disease,NA,NA,11505222 +Civic,VHL,N7D (c.19A>G),Von Hippel-Lindau Disease,NA,NA,Von Hippel-Lindau Disease,NA,NA,11536052 +Civic,VHL,P25L (c.74C>T),Von Hippel-Lindau Disease,NA,NA,Von Hippel-Lindau Disease,NA,NA,12114495 +Civic,VHL,P59fs (c.173_174insC),Von Hippel-Lindau Disease,NA,NA,Von Hippel-Lindau Disease,NA,NA,19270817 +Civic,VHL,Y98FS (c.291_310DEL20),Von Hippel-Lindau Disease,NA,NA,Von Hippel-Lindau Disease,NA,NA,15932632 +Civic,GNA11,MUTATION,Uveal Melanoma,NA,NA,Uveal Melanoma,NA,NA,24141786 +Civic,GNAQ,MUTATION,Uveal Melanoma,NA,NA,Uveal Melanoma,NA,NA,24141786 +Civic,NF1,MUTATION,Plexiform Neurofibroma,NA,NA,Plexiform Neurofibroma,NA,NA,28029918 +Civic,ATM,MUTATION,Prostate Cancer,NA,NA,Prostate Cancer,NA,NA,26510020 +Civic,PALB2,BIALLELIC INACTIVATION,Prostate Cancer,NA,NA,Prostate Cancer,NA,NA,26510020 +Civic,MET,AMPLIFICATION,Colorectal Cancer,NA,NA,Colorectal Cancer,NA,NA,23729478 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Carcinoma,NA,NA,Non-small Cell Lung Carcinoma,NA,NA,27315356 +Civic,KIT,V559D,Gastrointestinal Stromal Tumor,NA,NA,Gastrointestinal Stromal Tumor,NA,NA,22114577 +Civic,KIT,V559D,Cancer,NA,NA,Cancer,NA,NA,16046538 +Civic,AKT1,E17K,Cancer,NA,NA,Cancer,NA,NA,28489509 +Civic,PIK3CA,MUTATION,Cancer,NA,NA,Cancer,NA,NA,28489509 +Civic,TP53,R248Q,Cancer,NA,NA,Cancer,NA,NA,25730903 +Civic,CTNNB1,S45P,Desmoid Fibromatosis,NA,NA,Desmoid Fibromatosis,NA,NA,18832571 +Civic,CTNNB1,T41A,Desmoid Fibromatosis,NA,NA,Desmoid Fibromatosis,NA,NA,18832571 +Civic,GNAS,R201H,Follicular Thyroid Carcinoma,NA,NA,Follicular Thyroid Carcinoma,NA,NA,26788326 +Civic,BRAF,MUTATION,Colorectal Cancer,NA,NA,Colorectal Cancer,NA,NA,28486044 +Civic,GNA11,MUTATION,Uveal Melanoma,NA,NA,Uveal Melanoma,NA,NA,28103611 +Civic,NRAS,G12D,Colorectal Cancer,NA,NA,Colorectal Cancer,NA,NA,25666295 +Civic,KRAS,G12A,Colorectal Cancer,NA,NA,Colorectal Cancer,NA,NA,26161928 +Civic,BRAF,V600E,Colorectal Cancer,NA,NA,Colorectal Cancer,NA,NA,25666295 +Civic,EGFR,Ex19 del L858R,Lung Adenocarcinoma,NA,NA,Lung Adenocarcinoma,NA,NA,22285168 +Civic,EGFR,L861Q,Non-small Cell Lung Carcinoma,NA,NA,Non-small Cell Lung Carcinoma,NA,NA,21531810 +Civic,HRAS,G13D,Skin Squamous Cell Carcinoma,NA,NA,Skin Squamous Cell Carcinoma,NA,NA,22256804 +Civic,HRAS,G13D,Colorectal Cancer,NA,NA,Colorectal Cancer,NA,NA,26561417 +Civic,KRAS,A146T,Colorectal Cancer,NA,NA,Colorectal Cancer,NA,NA,25666295 +Civic,KRAS,Q61H,Colorectal Cancer,NA,NA,Colorectal Cancer,NA,NA,22722830 +Civic,KRAS,G13D,Colorectal Cancer,NA,NA,Colorectal Cancer,NA,NA,22722830 +Civic,KRAS,G13D,Colorectal Cancer,NA,NA,Colorectal Cancer,NA,NA,25666295 +Civic,KRAS,G12V,Colorectal Cancer,NA,NA,Colorectal Cancer,NA,NA,26161928 +Civic,KRAS,G12D,Colorectal Cancer,NA,NA,Colorectal Cancer,NA,NA,26161928 +Civic,KRAS,G12C,Colorectal Cancer,NA,NA,Colorectal Cancer,NA,NA,26161928 +Civic,KRAS,G12R,Colorectal Cancer,NA,NA,Colorectal Cancer,NA,NA,22722830 +Civic,KRAS,G12R,Colorectal Cancer,NA,NA,Colorectal Cancer,NA,NA,26161928 +Civic,KRAS,G12S,Colorectal Cancer,NA,NA,Colorectal Cancer,NA,NA,26161928 +Civic,FLT3,D835V,Acute Myeloid Leukemia,NA,NA,Acute Myeloid Leukemia,NA,NA,15459012 +Civic,AKT1,E17K,Melanoma,NA,NA,Melanoma,NA,NA,24265155 +Civic,IDH1,R132C,Glioblastoma Multiforme,NA,NA,Glioblastoma Multiforme,NA,NA,22199315 +Civic,PDGFRA,D842V,Gastrointestinal Stromal Tumor,NA,NA,Gastrointestinal Stromal Tumor,NA,NA,18955458 +Civic,EGFR,R108K,Malignant Glioma,NA,NA,Malignant Glioma,NA,NA,17177598 +Civic,EGFR,T263P,Malignant Glioma,NA,NA,Malignant Glioma,NA,NA,17177598 +Civic,EGFR,A289V,Malignant Glioma,NA,NA,Malignant Glioma,NA,NA,17177598 +Civic,EGFR,G719,Non-small Cell Lung Carcinoma,NA,NA,Non-small Cell Lung Carcinoma,NA,NA,21531810 +Civic,EGFR,G719D,Non-small Cell Lung Carcinoma,NA,NA,Non-small Cell Lung Carcinoma,NA,NA,21531810 +Civic,EGFR,L747P,Non-small Cell Lung Carcinoma,NA,NA,Non-small Cell Lung Carcinoma,NA,NA,21531810 +Civic,EGFR,V774A,Non-small Cell Lung Carcinoma,NA,NA,Non-small Cell Lung Carcinoma,NA,NA,21531810 +Civic,EGFR,V774M,Non-small Cell Lung Carcinoma,NA,NA,Non-small Cell Lung Carcinoma,NA,NA,21531810 +Civic,EGFR,K806E,Non-small Cell Lung Carcinoma,NA,NA,Non-small Cell Lung Carcinoma,NA,NA,21531810 +Civic,EGFR,N826Y,Non-small Cell Lung Carcinoma,NA,NA,Non-small Cell Lung Carcinoma,NA,NA,21531810 +Civic,EGFR,V834I,Non-small Cell Lung Carcinoma,NA,NA,Non-small Cell Lung Carcinoma,NA,NA,21531810 +Civic,EGFR,L838P,Non-small Cell Lung Carcinoma,NA,NA,Non-small Cell Lung Carcinoma,NA,NA,21531810 +Civic,EGFR,N842S,Non-small Cell Lung Carcinoma,NA,NA,Non-small Cell Lung Carcinoma,NA,NA,21531810 +Civic,EGFR,T847I,Non-small Cell Lung Carcinoma,NA,NA,Non-small Cell Lung Carcinoma,NA,NA,21531810 +Civic,EGFR,V851I,Non-small Cell Lung Carcinoma,NA,NA,Non-small Cell Lung Carcinoma,NA,NA,21531810 +Civic,EGFR,L858R,Malignant Glioma,NA,NA,Malignant Glioma,NA,NA,17177598 +Civic,EGFR,L861,Non-small Cell Lung Carcinoma,NA,NA,Non-small Cell Lung Carcinoma,NA,NA,21531810 +Civic,EGFR,L861Q,Malignant Glioma,NA,NA,Malignant Glioma,NA,NA,17177598 +Civic,AKT1,Q79K,Melanoma,NA,NA,Melanoma,NA,NA,24265155 +Civic,EGFR,VIII,Malignant Glioma,NA,NA,Malignant Glioma,NA,NA,17177598 +Civic,ABL1,BCR-ABL G398R,Chronic Myeloid Leukemia,NA,NA,Chronic Myeloid Leukemia,NA,NA,19075254 +Civic,SMO,L412F,Basal Cell Carcinoma,NA,NA,Basal Cell Carcinoma,NA,NA,25759020 +Civic,SMO,L412F,Basal Cell Carcinoma,NA,NA,Basal Cell Carcinoma,NA,NA,26822128 +Civic,EGFR,L861R,Non-small Cell Lung Carcinoma,NA,NA,Non-small Cell Lung Carcinoma,NA,NA,21531810 +Civic,EGFR,RARE EX 18-21 MUT,Non-small Cell Lung Carcinoma,NA,NA,Non-small Cell Lung Carcinoma,NA,NA,21531810 +Civic,EGFR,Ex19 del L858R,Non-small Cell Lung Carcinoma,NA,NA,Non-small Cell Lung Carcinoma,NA,NA,21531810 +Civic,EGFR,RARE EX 18-21 MUT,Non-small Cell Lung Carcinoma,NA,NA,Non-small Cell Lung Carcinoma,NA,NA,21531810 +Civic,EGFR,EXON 19 DELETION,Lung Adenocarcinoma,NA,NA,Lung Adenocarcinoma,NA,NA,27566387 +Civic,NRAS,Q179X,Colorectal Cancer,NA,NA,Colorectal Cancer,NA,NA,25666295 +Civic,MET,EXON 14 SKIPPING MUTATION,Lung Adenocarcinoma,NA,NA,Lung Adenocarcinoma,NA,NA,25769807 +Civic,ESR1,D538G,Breast Cancer,NA,NA,Breast Cancer,NA,NA,27556863 +Civic,JAK2,F547 SPLICE SITE MUTATION,Melanoma,NA,NA,Melanoma,NA,NA,27433843 +Civic,IDH2,MUTATION,Acute Myeloid Leukemia,NA,NA,Acute Myeloid Leukemia,NA,NA,28193778 +Civic,BRCA1,LOSS-OF-FUNCTION,Breast Cancer,NA,NA,Breast Cancer,NA,NA,28242752 +Civic,BRCA2,LOSS-OF-FUNCTION,Breast Cancer,NA,NA,Breast Cancer,NA,NA,28242752 +Civic,CDK4,AMPLIFICATION,Liposarcoma,NA,NA,Liposarcoma,NA,NA,27124835 +Civic,CD274,EXPRESSION,Breast Cancer,NA,NA,Breast Cancer,NA,NA,28079291 +Civic,ACVR1,Gain-of-Function,Astrocytoma,NA,NA,Astrocytoma,NA,NA,24705250 +Civic,CD274,EXPRESSION,Breast Cancer,NA,NA,Breast Cancer,NA,NA,28430626 +Civic,CD274,EXPRESSION,Cancer,NA,NA,Cancer,NA,NA,28453554 +Civic,CD274,EXPRESSION,Non-small Cell Lung Carcinoma,NA,NA,Non-small Cell Lung Carcinoma,NA,NA,28472902 +Civic,ALK,ALK FUSIONS,Non-small Cell Lung Carcinoma,NA,NA,Non-small Cell Lung Carcinoma,NA,NA,28586279 +Civic,EGFR,EXON 19 DELETION,Non-small Cell Lung Carcinoma,NA,NA,Non-small Cell Lung Carcinoma,NA,NA,26768165 +Civic,KRAS,MUTATION,Non-small Cell Lung Carcinoma,NA,NA,Non-small Cell Lung Carcinoma,NA,NA,28525386 +Civic,KRAS,MUTATION,Non-small Cell Lung Carcinoma,NA,NA,Non-small Cell Lung Carcinoma,NA,NA,28259530 +Civic,KRAS,MUTATION,Non-small Cell Lung Carcinoma,NA,NA,Non-small Cell Lung Carcinoma,NA,NA,25722381 +Civic,KRAS,MUTATION,Non-small Cell Lung Carcinoma,NA,NA,Non-small Cell Lung Carcinoma,NA,NA,26802155 +Civic,CDK4,EXPRESSION,Sarcoma,NA,NA,Sarcoma,NA,NA,26528855 +Civic,BRCA2,LOSS-OF-FUNCTION,Ovarian Cancer,NA,NA,Ovarian Cancer,NA,NA,28242752 +Civic,BRCA1,LOSS-OF-FUNCTION,Ovarian Cancer,NA,NA,Ovarian Cancer,NA,NA,28242752 +Civic,EGFR,EXPRESSION,Non-small Cell Lung Carcinoma,NA,NA,Non-small Cell Lung Carcinoma,NA,NA,12748244 +Civic,VHL,A149T (c.445G>A),Von Hippel-Lindau Disease,NA,NA,Von Hippel-Lindau Disease,NA,NA,7728151 +Civic,VHL,C162F (c.485G>T),Von Hippel-Lindau Disease,NA,NA,Von Hippel-Lindau Disease,NA,NA,7728151 +Civic,VHL,A56D (c.167insA),Von Hippel-Lindau Disease,NA,NA,Von Hippel-Lindau Disease,NA,NA,7987306 +Civic,KRAS,MUTATION,Non-small Cell Lung Carcinoma,NA,NA,Non-small Cell Lung Carcinoma,NA,NA,26209642 +Civic,KRAS,MUTATION,Non-small Cell Lung Carcinoma,NA,NA,Non-small Cell Lung Carcinoma,NA,NA,20038723 +Civic,POLE,S459F,Colorectal Cancer,NA,NA,Colorectal Cancer,NA,NA,28404093 +Civic,VHL,C162F (c.485G>T),Von Hippel-Lindau Disease,NA,NA,Von Hippel-Lindau Disease,NA,NA,9829911 +Civic,GNAQ,MUTATION,Uveal Melanoma,NA,NA,Uveal Melanoma,NA,NA,28103611 +Civic,IDH2,MUTATION,Acute Myeloid Leukemia,NA,NA,Acute Myeloid Leukemia,NA,NA,28588020 +Civic,CTNNB1,T41A,Desmoid Fibromatosis,NA,NA,Desmoid Fibromatosis,NA,NA,22766794 +Civic,CTNNB1,S45F,Desmoid Fibromatosis,NA,NA,Desmoid Fibromatosis,NA,NA,22766794 +Civic,CTNNB1,S45P,Desmoid Fibromatosis,NA,NA,Desmoid Fibromatosis,NA,NA,22766794 +Civic,VHL,V74fs (c.223_224insT),Von Hippel-Lindau Disease,NA,NA,Von Hippel-Lindau Disease,NA,NA,19270817 +Civic,VHL,C162R (c.484T>C),Von Hippel-Lindau Disease,NA,NA,Von Hippel-Lindau Disease,NA,NA,19270817 +Civic,VHL,K196* (c.586A>T),Von Hippel-Lindau Disease,NA,NA,Von Hippel-Lindau Disease,NA,NA,19270817 +Civic,VHL,C162F (c.485G>T),Von Hippel-Lindau Disease,NA,NA,Von Hippel-Lindau Disease,NA,NA,21463266 +Civic,VHL,N78S (c.233A>G),Von Hippel-Lindau Disease,NA,NA,Von Hippel-Lindau Disease,NA,NA,19464396 +Civic,FLT3,MUTATION,Acute Myeloid Leukemia,NA,NA,Acute Myeloid Leukemia,NA,NA,28546144 +Civic,VHL,X214L (c.641G>T),Von Hippel-Lindau Disease,NA,NA,Von Hippel-Lindau Disease,NA,NA,20560986 +Civic,VHL,*214Wext*15 (c.642A>G),Von Hippel-Lindau Disease,NA,NA,Von Hippel-Lindau Disease,NA,NA,20560986 +Civic,BAP1,MUTATION,Renal Cell Carcinoma,NA,NA,Renal Cell Carcinoma,NA,NA,27751729 +Civic,RRM1,UNDEREXPRESSION,Pancreatic Cancer,NA,NA,Pancreatic Cancer,NA,NA,19543324 +Civic,CD274,EXPRESSION,Cancer,NA,NA,Cancer,NA,NA,28471952 +Synapse,ABL1,T315A,NA,GOF,NA,NA,NA,NA,",NCCN,,,,,," +Synapse,ABL1,T315I,NA,GOF,NA,NA,NA,NA,",NCCN,22772060,25686603,,,," +Synapse,ABL1,F317L/V/I/C,NA,GOF,NA,NA,NA,NA,",NCCN,,,,,," +Synapse,ABL1,F359V/C/I,NA,GOF,NA,NA,NA,NA,",NCCN,,,,,," +Synapse,ABL1,Y253H,NA,GOF,NA,NA,NA,NA,",NCCN,,,,,," +Synapse,ABL1,E255K/V,NA,GOF,NA,NA,NA,NA,",NCCN,,,,,," +Synapse,ABL1,V299L,NA,GOF,NA,NA,NA,NA,",NCCN,,,,,," +Synapse,ABL1,T315A,NA,GOF,NA,NA,NA,NA,",21562040,,,,,," +Synapse,ABL1,T315I,NA,GOF,NA,NA,NA,NA,",21562040,,,,,," +Synapse,ABL1,F317L/V/I/C,NA,GOF,NA,NA,NA,NA,",21562040,,,,,," +Synapse,ABL1,F359V/C/I,NA,GOF,NA,NA,NA,NA,",21562040,,,,,," +Synapse,ABL1,Y253H,NA,GOF,NA,NA,NA,NA,",21562040,,,,,," +Synapse,ABL1,E255K/V,NA,GOF,NA,NA,NA,NA,",21562040,,,,,," +Synapse,ABL1,V299L,NA,GOF,NA,NA,NA,NA,",21562040,,,,,," +Synapse,AKT1,E17K,NA,GOF,NA,NA,NA,NA,",21464312, 17611497,,,,,," +Synapse,AKT1,E17K,NA,GOF,NA,NA,NA,NA,",ENA 2015 (abstract B109), 28489509,,,,,," +Synapse,AKT1,E17K,NA,GOF,NA,NA,NA,NA,",21464312, 17611497, 23134728,,,,,," +Synapse,AKT1,H238Y,NA,GOF,NA,NA,NA,NA,",ASCO 2015 (abstr 11010),,,,,," +Synapse,AKT1,Q79K,NA,GOF,NA,NA,NA,NA,",24265152,,,,,," +Synapse,AKT1,E17K,NA,GOF,NA,NA,NA,NA,",26763254,,,,,," +Synapse,AKT1,E17K,NA,GOF,NA,NA,NA,NA,",27016228,,,,,," +Synapse,AKT2,amplification,NA,GOF,NA,NA,NA,NA,",ENA 2014 (abstr 373),,,,,," +Synapse,AKT3,rearrangement,NA,GOF,NA,NA,NA,NA,",22722202,,,,,," +Synapse,ALK,rearrangement,NA,GOF,NA,NA,NA,NA,",26633560, 26933125,,,,,," +Synapse,ALK,rearrangement,NA,GOF,NA,NA,NA,NA,",20979472,27742657,,,,," +Synapse,ALK,G1128A,NA,GOF,NA,NA,NA,NA,",http://ascopubs.org/doi/full/10.1200/PO.17.00015,,,,,," +Synapse,ALK,rearrangement,NA,GOF,NA,NA,NA,NA,",FDA,23639470,23553849,25173427,25394791,," +Synapse,ALK,F856S,NA,GOF,NA,NA,NA,NA,",26032424,,,,,," +Synapse,ALK,A348D,NA,GOF,NA,NA,NA,NA,",26032424,,,,,," +Synapse,ALK,R1275Q ,NA,GOF,NA,NA,NA,NA,",22072639,,,,,," +Synapse,ALK,F1174L,NA,GOF,NA,NA,NA,NA,",22072639,,,,,," +Synapse,ALK,G1128A,NA,GOF,NA,NA,NA,NA,",22072639,,,,,," +Synapse,ALK,I1171N ,NA,GOF,NA,NA,NA,NA,",22072639,,,,,," +Synapse,ALK,R1192P,NA,GOF,NA,NA,NA,NA,",22072639,,,,,," +Synapse,ALK,F1245C,NA,GOF,NA,NA,NA,NA,",22072639,,,,,," +Synapse,ALK,L1196M,NA,GOF,NA,NA,NA,NA,",22277784,24670165, 24327273,ASCO 2017 (abstr 9065),,,," +Synapse,ALK,L1198F,NA,GOF,NA,NA,NA,NA,",26698910,26698910,,,,," +Synapse,ALK,L1152R,NA,GOF,NA,NA,NA,NA,",22277784,,,,,," +Synapse,ALK, C1156Y,NA,GOF,NA,NA,NA,NA,",22277784,27401242,,,,," +Synapse,ALK,F1174L,NA,GOF,NA,NA,NA,NA,",22277784,24327273,,,,," +Synapse,ALK,G1202R,NA,GOF,NA,NA,NA,NA,",22277784,,,,,," +Synapse,ALK, S1206Y,NA,GOF,NA,NA,NA,NA,",22277784,24670165,,,,," +Synapse,ALK,G1269A,NA,GOF,NA,NA,NA,NA,",22277784,24670165,,,,," +Synapse,ALK, 1151Tins,NA,GOF,NA,NA,NA,NA,",22277784,24670165,,,,," +Synapse,ALK,I1171T,NA,GOF,NA,NA,NA,NA,",25228534,25228534,,,,," +Synapse,ALK,amplification,NA,GOF,NA,NA,NA,NA,",22277784,ASCO 2017 (abstr 9065),,,,," +Synapse,ALK,E1408V,NA,GOF,NA,NA,NA,NA,",ASCO 2017 (abstr 9065),,,,,," +Synapse,ALK,rearrangement,NA,GOF,NA,NA,NA,NA,",24491302,,,,,," +Synapse,ALK,rearrangement,NA,GOF,NA,NA,NA,NA,",24687827,,,,,," +Synapse,APC,any,NA,LOF,NA,NA,NA,NA,",22440753, 23539443 ,,,,,," +Synapse,AR,F877L/T878A coexisting,NA,GOF,NA,NA,NA,NA,",27196756,,,,,," +Synapse,AR ,F876L ,NA,GOF,NA,NA,NA,NA,",23779130,,,,,," +Synapse,AR ,T877A,NA,GOF,NA,NA,NA,NA,",2260966,23779130,,,,," +Synapse,AR ,W741,NA,GOF,NA,NA,NA,NA,",12517791,23779130,,,,," +Synapse,AR ,L702H,NA,GOF,NA,NA,NA,NA,",26537258,,,,,," +Synapse,AR ,T878A,NA,GOF,NA,NA,NA,NA,",26537258,,,,,," +Synapse,AR ,amplification,NA,GOF,NA,NA,NA,NA,",26537258,,,,,," +Synapse,AR ,amplification,NA,GOF,NA,NA,NA,NA,",23589709, 21859989,,,,,," +Synapse,AR-V7,splice variant mRNA,NA,GOF,NA,NA,NA,NA,",25184630,,,,,," +Synapse,ARAF,unknown,NA,GOF,NA,NA,NA,NA,",ENA 2014 (abstr 428),,,,,," +Synapse,ARAF,S214C,NA,GOF,NA,NA,NA,NA,",24569458,,,,,," +Synapse,AREG,amplification,NA,GOF,NA,NA,NA,NA,",19738126, 26341080,,,,,," +Synapse,ARID1A,mut,NA,LOF,NA,NA,NA,NA,",27172896,,,,,," +Synapse,ARID1A,mut,NA,LOF,NA,NA,NA,NA,",26069190,26552009,,,,," +Synapse,ARID1A,any,NA,LOF,NA,NA,NA,NA,",25686104,,,,,," +Synapse,ARID1A,any,NA,LOF,NA,NA,NA,NA,",27958275,,,,,," +Synapse,ATM,any,NA,LOF,NA,NA,NA,NA,",26238431,,,,,," +Synapse,ATM,any,NA,LOF,NA,NA,NA,NA,",ENA 2015 (abstract A48),,,,,," +Synapse,ATM,any,NA,LOF,NA,NA,NA,NA,",ENA 2014 (abstr 8LBA),,,,,," +Synapse,ATM,any,NA,LOF,NA,NA,NA,NA,",23960094,,,,,," +Synapse,ATM,any,NA,LOF,NA,NA,NA,NA,",23761041,,,,,," +Synapse,ATM,any,NA,LOF,NA,NA,NA,NA,",26510020,,,,,," +Synapse,ATR,any,NA,LOF,NA,NA,NA,NA,",23548269,,,,,," +Synapse,ATR,any,NA,LOF,NA,NA,NA,NA,",23960094,,,,,," +Synapse,AURKA,amplification,NA,GOF,NA,NA,NA,NA,",22302096,,,,,," +Synapse,AURKA,amplification,NA,GOF,NA,NA,NA,NA,",22389870,,,,,," +Synapse,B2M,any,NA,LOF,NA,NA,NA,NA,",27433843,,,,,," +Synapse,BAP1,any,NA,LOF,NA,NA,NA,NA,",22683710,,,,,," +Synapse,BAP1,any,NA,LOF,NA,NA,NA,NA,",22038994,,,,,," +Synapse,BAP1,any,NA,LOF,NA,NA,NA,NA,",26437366,,,,,," +Synapse,BAP1,any,NA,LOF,NA,NA,NA,NA,",22683710,,,,,," +Synapse,BCL2,amplification,NA,GOF,NA,NA,NA,NA,",22649144,,,,,," +Synapse,BCOR,mut,NA,LOF,NA,NA,NA,NA,",27397505,,,,,," +Synapse,BCR-ABL1,rearrangement,NA,GOF,NA,NA,NA,NA,",27582059,,,,,," +Synapse,BCR-ABL1,rearrangement,NA,GOF,NA,NA,NA,NA,",FDA,,,,,," +Synapse,BCR-ABL1,rearrangement,NA,GOF,NA,NA,NA,NA,",NCCN,,,,,," +Synapse,BCR-ABL1,rearrangement,NA,GOF,NA,NA,NA,NA,",FDA,,,,,," +Synapse,BCR-ABL1,rearrangement,NA,GOF,NA,NA,NA,NA,",FDA,,,,,," +Synapse,BCR-JAK2,rearrangement,NA,GOF,NA,NA,NA,NA,",22897847,,,,,," +Synapse,BRAF,V600E,NA,GOF,NA,NA,NA,NA,",22773810,27283860,27080216,22743296,ASCO 2017 (abstr 2508),," +Synapse,BRAF,V600,NA,GOF,NA,NA,NA,NA,",20619739, 21163703, 23325582 ,26460303,26392102, ASCO 2014 (abstr 3515), ASCO 2015 (abstr 103) ,28363909,," +Synapse,BRAF,V600E,NA,GOF,NA,NA,NA,NA,",23470635, 22608338,,,,,," +Synapse,BRAF,V600E,NA,GOF,NA,NA,NA,NA,",22038996, 22586120,,,,,," +Synapse,BRAF,V600E,NA,GOF,NA,NA,NA,NA,",22621641,,,,,," +Synapse,BRAF,Y472C,NA,LOF,NA,NA,NA,NA,",22649091,,,,,," +Synapse,BRAF,G466V,NA,LOF,NA,NA,NA,NA,",22649091,,,,,," +Synapse,BRAF,rearrangement,NA,GOF,NA,NA,NA,NA,",ASCO 2017 (abstr 9072),24727320,,,,," +Synapse,BRAF,rearrangement,NA,GOF,NA,NA,NA,NA,",24345920,238900088,,,,," +Synapse,BRAF,V600E,NA,GOF,NA,NA,NA,NA,",22608338,19018267,,,,," +Synapse,BRAF,rearrangement,NA,GOF,NA,NA,NA,NA,",26324360,,,,,," +Synapse,BRAF,rearrangement,NA,GOF,NA,NA,NA,NA,",20526349,,,,,," +Synapse,BRAF,"V600D,V600K,V600M,V600G,V600R",NA,GOF,NA,NA,NA,NA,",NCCN,,,,,," +Synapse,BRAF,V600E,NA,GOF,NA,NA,NA,NA,",27048246,,,,,," +Synapse,BRAF,G469A ,NA,GOF,NA,NA,NA,NA,",ASCO 2017 (abstr 2508),,,,,," +Synapse,BRAF,L485W,NA,GOF,NA,NA,NA,NA,",ASCO 2017 (abstr 2508),,,,,," +Synapse,BRAF ,V600E,NA,GOF,NA,NA,NA,NA,",22608338, 20818844, 23489023, 27460442,22241789,23406027,ASCO 2013 (abstr 9029),AACR 2016 (abstr CT005),," +Synapse,BRAF ,L485-P490,NA,GOF,NA,NA,NA,NA,",26732095,26732095,,,,," +Synapse,BRAF ,G469A ,NA,GOF,NA,NA,NA,NA,",22773810,22773810,,,,," +Synapse,BRAF ,V600K,NA,GOF,NA,NA,NA,NA,",FDA,22356324,,,,," +Synapse,BRAF ,V600R,NA,GOF,NA,NA,NA,NA,",23237741,23248257,,,,," +Synapse,BRAF ,K601R,NA,GOF,NA,NA,NA,NA,",23248257,,,,,," +Synapse,BRAF ,L597R,NA,GOF,NA,NA,NA,NA,",22805292, 22798288,23715574,,,,," +Synapse,BRAF ,D594G,NA,GOF,NA,NA,NA,NA,",18794803,,,,,," +Synapse,BRAF ,G469E ,NA,GOF,NA,NA,NA,NA,",18794803,,,,,," +Synapse,BRAF ,V600E,NA,GOF,NA,NA,NA,NA,",23612012,,,,,," +Synapse,BRAF ,V600E,NA,GOF,NA,NA,NA,NA,",FDA,ESMO 2015 (abstract 300), AACR 2016 (abstr CT005), AACR 2017 (abstr CT002),22389471, 21156289 ,22351686,22997239,," +Synapse,BRCA1,any,NA,LOF,NA,NA,NA,NA,",20609467, 25366685,25847936,26801247,,,," +Synapse,BRCA1,any,NA,LOF,NA,NA,NA,NA,",25964244,,,,,," +Synapse,BRCA1,any,NA,LOF,NA,NA,NA,NA,",FDA,22406760, 22711857 ,22307137, ASCO 2012 (abstr 1009),,,," +Synapse,BRCA1,deletion,NA,LOF,NA,NA,NA,NA,",22392482,,,,,," +Synapse,BRCA1,any,NA,LOF,NA,NA,NA,NA,",25366685, 25719666,,,,,," +Synapse,BRCA1,any,NA,LOF,NA,NA,NA,NA,",19553641, 25366685, 26510020,,,,,," +Synapse,BRCA2,any,NA,LOF,NA,NA,NA,NA,",20609467,25847936,26801247,,,," +Synapse,BRCA2,any,NA,LOF,NA,NA,NA,NA,",26997480,,,,,," +Synapse,BRCA2,any,NA,LOF,NA,NA,NA,NA,",FDA,22406760, 22711857 ,22307137, ASCO 2012 (abstr 1009),,,," +Synapse,BRCA2,deletion,NA,LOF,NA,NA,NA,NA,",22392482,,,,,," +Synapse,BRCA2,any,NA,LOF,NA,NA,NA,NA,",25719666,,,,,," +Synapse,BRCA2,any,NA,LOF,NA,NA,NA,NA,",26510020,,,,,," +Synapse,BRD4,BRD4-NUT fusion,NA,GOF,NA,NA,NA,NA,",ENA 2015 (abstract A49),,,,,," +Synapse,BTK,C481,NA,GOF,NA,NA,NA,NA,",25082755,,,,,," +Synapse,BTK,C481S,NA,GOF,NA,NA,NA,NA,",24869598, 27199251,,,,,," +Synapse,CBL,Y371H,NA,GOF,NA,NA,NA,NA,",23696637,,,,,," +Synapse,CBL,C384R,NA,GOF,NA,NA,NA,NA,",23696637,,,,,," +Synapse,CCND1,amplification,NA,GOF,NA,NA,NA,NA,",22471707,,,,,," +Synapse,CCND1,amplification,NA,GOF,NA,NA,NA,NA,",ASCO 2014 (abstr 2528^),,,,,," +Synapse,CCND1,amplification,NA,GOF,NA,NA,NA,NA,",ASCO 2017 (abstr 9056),,,,,," +Synapse,CCND2,amplification,NA,GOF,NA,NA,NA,NA,",22471707,,,,,," +Synapse,CCND3,amplification,NA,GOF,NA,NA,NA,NA,",22471707,,,,,," +Synapse,CCNE1,amplification,NA,GOF,NA,NA,NA,NA,",22471707,,,,,," +Synapse,CD274,amplification,NA,GOF,NA,NA,NA,NA,",25079317,,,,,," +Synapse,CD274,amplification,NA,GOF,NA,NA,NA,NA,",27942391,,,,,," +Synapse,CDH1,mut,NA,LOF,NA,NA,NA,NA,",27397505,,,,,," +Synapse,CDK12,any,NA,LOF,NA,NA,NA,NA,", 24240700, 24554720,,,,,," +Synapse,CDK4,amplification,NA,GOF,NA,NA,NA,NA,",23569312,,,,,," +Synapse,CDK4,amplification,NA,GOF,NA,NA,NA,NA,",ASCO 2017 (abstr 9056),,,,,," +Synapse,CDK6,amplification,NA,GOF,NA,NA,NA,NA,",22471707,,,,,," +Synapse,CDKN1A,any,NA,LOF,NA,NA,NA,NA,",22471707, 22997239,,,,,," +Synapse,CDKN1B,any,NA,LOF,NA,NA,NA,NA,",22471707,,,,,," +Synapse,CDKN2A,any,NA,LOF,NA,NA,NA,NA,",22471707,,,,,," +Synapse,CDKN2A,any,NA,LOF,NA,NA,NA,NA,",22586120, 22711607,,,,,," +Synapse,CDKN2A,any,NA,LOF,NA,NA,NA,NA,",ASCO 2013 (abstr 2500),,,,,," +Synapse,CDKN2B,any,NA,LOF,NA,NA,NA,NA,",22471707,,,,,," +Synapse,CDKN2B,any,NA,LOF,NA,NA,NA,NA,",22711607,,,,,," +Synapse,CDKN2C,any,NA,LOF,NA,NA,NA,NA,",22471707, 22997239,,,,,," +Synapse,CDKN2C,any,NA,LOF,NA,NA,NA,NA,",22711607,,,,,," +Synapse,CHEK2,any,NA,LOF,NA,NA,NA,NA,",AACR 2015 (abstr CT322), 26510020,,,,,," +Synapse,COL1A1-PDGFRB ,rearrangement,NA,GOF,NA,NA,NA,NA,",FDA,,,,,," +Synapse,CRLF2,rearrangement,NA,GOF,NA,NA,NA,NA,",22904298,22955920,,,,," +Synapse,CSF1R,Y571D,NA,GOF,NA,NA,NA,NA,",18971950,,,,,," +Synapse,CSF3R,T615A,NA,GOF,NA,NA,NA,NA,",23656643,,,,,," +Synapse,CSF3R,Q741X ,NA,GOF,NA,NA,NA,NA,",23656643,,,,,," +Synapse,CSF3R,Y752X,NA,GOF,NA,NA,NA,NA,",23656643,,,,,," +Synapse,CSF3R,W791X,NA,GOF,NA,NA,NA,NA,",23656643,,,,,," +Synapse,CSF3R,D771fs,NA,GOF,NA,NA,NA,NA,",23656643,,,,,," +Synapse,CSF3R,S783fs,NA,GOF,NA,NA,NA,NA,",23656643,,,,,," +Synapse,CSF3R,T618I,NA,GOF,NA,NA,NA,NA,",23656643,,,,,," +Synapse,CTNNB1,any,NA,GOF,NA,NA,NA,NA,",23539443,,,,,," +Synapse,CTNNB1,"H36Y, S37C, S37Y, D32V",NA,GOF,NA,NA,NA,NA,",25624430,,,,,," +Synapse,DDR2,S768R,NA,GOF,NA,NA,NA,NA,",22328973,22328973,,,,," +Synapse,DDR2, I638F ,NA,GOF,NA,NA,NA,NA,",22328973,,,,,," +Synapse,DDR2,L239R,NA,GOF,NA,NA,NA,NA,",22328973,,,,,," +Synapse,DDR2,G253C,NA,GOF,NA,NA,NA,NA,",22328973,,,,,," +Synapse,DDR2,G774V,NA,GOF,NA,NA,NA,NA,",22328973,,,,,," +Synapse,DDR2,L63V,NA,GOF,NA,NA,NA,NA,",22328973,,,,,," +Synapse,DDR2,G505S,NA,GOF,NA,NA,NA,NA,",22328973,,,,,," +Synapse,DNMT3A,any,NA,LOF,NA,NA,NA,NA,",22417203,,,,,," +Synapse,EGFR,exon 20 p.762-823,NA,GOF,NA,NA,NA,NA,",21764376, 26773740, 26051236,ASCO 2014 (abstr 8015),26515464,,,," +Synapse,EGFR,S720,NA,GOF,NA,NA,NA,NA,",26773740,,,,,," +Synapse,EGFR,"K757R, E746G",NA,GOF,NA,NA,NA,NA,",26773740,,,,,," +Synapse,EGFR,V769_770insASV,NA,GOF,NA,NA,NA,NA,",26773740, 23328547,,,,,," +Synapse,EGFR," S464L, G465R, I491M",NA,GOF,NA,NA,NA,NA,",25623215,,,,,," +Synapse,EGFR,G465R,NA,GOF,NA,NA,NA,NA,",26059438, 26888827,,,,,," +Synapse,EGFR,R451C,NA,GOF,NA,NA,NA,NA,",25623215,,,,,," +Synapse,EGFR,K467T,NA,GOF,NA,NA,NA,NA,",25623215, 26888827,25623215,,,,," +Synapse,EGFR,S492R,NA,GOF,NA,NA,NA,NA,",22270724,22270724,25962717,,,," +Synapse,EGFR,amplification,NA,GOF,NA,NA,NA,NA,",18794099, 17664472,,,,,," +Synapse,EGFR,E690K,NA,GOF,NA,NA,NA,NA,",22885469,,,,,," +Synapse,EGFR,amplification,NA,GOF,NA,NA,NA,NA,",24950987,,,,,," +Synapse,EGFR,A289V,NA,GOF,NA,NA,NA,NA,",17177598,,,,,," +Synapse,EGFR,R108K,NA,GOF,NA,NA,NA,NA,",17177598,,,,,," +Synapse,EGFR,G598V,NA,GOF,NA,NA,NA,NA,",17177598,,,,,," +Synapse,EGFR,T263P,NA,GOF,NA,NA,NA,NA,",17177598,,,,,," +Synapse,EGFR,amplification,NA,GOF,NA,NA,NA,NA,",16282176, 16278407 ,,,,,," +Synapse,EGFR,exon 2-7 p.30-336,NA,GOF,NA,NA,NA,NA,",19204207,,,,,," +Synapse,EGFR,amplification,NA,GOF,NA,NA,NA,NA,",21274259, 22261807,26763254,,,,," +Synapse,EGFR,V843I,NA,GOF,NA,NA,NA,NA,",21274259,,,,,," +Synapse,EGFR,delL747-P753insS,NA,GOF,NA,NA,NA,NA,",21274259,,,,,," +Synapse,EGFR,P546S,NA,GOF,NA,NA,NA,NA,",23578570,,,,,," +Synapse,EGFR,P753S,NA,GOF,NA,NA,NA,NA,",24934779,,,,,," +Synapse,EGFR,L858R,NA,GOF,NA,NA,NA,NA,",FDA,22753918,ESMO 2012 (abstr 1289),ESMO 2012 (abstr 4380),23102728,," +Synapse,EGFR,L861Q,NA,GOF,NA,NA,NA,NA,",NCCN,22753918,ESMO 2012 (abstr 1289),ESMO 2012 (abstr 4380),23102728,," +Synapse,EGFR,G719A,NA,GOF,NA,NA,NA,NA,",NCCN,22753918,ESMO 2012 (abstr 1289),ESMO 2012 (abstr 4380),23102728,," +Synapse,EGFR,G719S,NA,GOF,NA,NA,NA,NA,",NCCN,22753918,ESMO 2012 (abstr 1289),ESMO 2012 (abstr 4380),23102728,," +Synapse,EGFR,G719C,NA,GOF,NA,NA,NA,NA,",NCCN,22753918,ESMO 2012 (abstr 1289),ESMO 2012 (abstr 4380),23102728,," +Synapse,EGFR,G719D,NA,GOF,NA,NA,NA,NA,",NCCN,22753918,ESMO 2012 (abstr 1289),ESMO 2012 (abstr 4380),23102728,," +Synapse,EGFR,L747S,NA,GOF,NA,NA,NA,NA,",NCCN,22753918,ESMO 2012 (abstr 1289),ESMO 2012 (abstr 4380),23102728,," +Synapse,EGFR,S768I,NA,GOF,NA,NA,NA,NA,",NCCN,22753918,ESMO 2012 (abstr 1289),ESMO 2012 (abstr 4380),23102728,," +Synapse,EGFR,L861P,NA,GOF,NA,NA,NA,NA,",NCCN,22753918,ESMO 2012 (abstr 1289),ESMO 2012 (abstr 4380),23102728,," +Synapse,EGFR,L861Q,NA,GOF,NA,NA,NA,NA,",NCCN,22753918,ESMO 2012 (abstr 1289),ESMO 2012 (abstr 4380),23102728,," +Synapse,EGFR,L861R,NA,GOF,NA,NA,NA,NA,",NCCN,22753918,ESMO 2012 (abstr 1289),ESMO 2012 (abstr 4380),23102728,," +Synapse,EGFR,C797S,NA,GOF,NA,NA,NA,NA,",25939061,,,,,," +Synapse,EGFR,L792,NA,GOF,NA,NA,NA,NA,",ASCO 2017 (abstr 2572),,,,,," +Synapse,EGFR,L718,NA,GOF,NA,NA,NA,NA,",ASCO 2017 (abstr 2572),,,,,," +Synapse,EGFR,exon 19 p.729-761,NA,GOF,NA,NA,NA,NA,",22190593,22753918,ESMO 2012 (abstr 1289),ESMO 2012 (abstr 4380),23102728,," +Synapse,EGFR,exon 19 p.729-761,NA,GOF,NA,NA,NA,NA,",FDA,22753918, 25589191,ESMO 2012 (abstr 1289),ESMO 2012 (abstr 4380),23102728,," +Synapse,EGFR,amplification,NA,GOF,NA,NA,NA,NA,",ASCO 2015 (abstr e19028),,,,,," +Synapse,EGFR,T790M,NA,GOF,NA,NA,NA,NA,",NCCN,FDA,25074459,26667485,ESMO 2012 (abstr 4380),emerging," +Synapse,EGFR,L798I,NA,GOF,NA,NA,NA,NA,",27283993,,,,,," +Synapse,EGFR-RAD51,rearrangement,NA,GOF,NA,NA,NA,NA,",27102076,,,,,," +Synapse,EPHA2,amplification,NA,GOF,NA,NA,NA,NA,",18047674, 19010823, 19861960,,,,,," +Synapse,EPHA2,G391R,NA,GOF,NA,NA,NA,NA,",20360610,,,,,," +Synapse,EPHA3,amplification,NA,GOF,NA,NA,NA,NA,",25125683,,,,,," +Synapse,ERBB2,K753E,NA,GOF,NA,NA,NA,NA,",27697991,27697991,,,,," +Synapse,ERBB2,amplification,NA,GOF,NA,NA,NA,NA,",26022204,,,,,," +Synapse,ERBB2,L755S,NA,GOF,NA,NA,NA,NA,",23220880,,,,,," +Synapse,ERBB2,L869R,NA,GOF,NA,NA,NA,NA,",28274957,,,,,," +Synapse,ERBB2,T798I,NA,GOF,NA,NA,NA,NA,",28274957,28274957,,,,," +Synapse,ERBB2,G309A,NA,GOF,NA,NA,NA,NA,",23220880,,,,,," +Synapse,ERBB2,755-759del,NA,GOF,NA,NA,NA,NA,",23220880,,,,,," +Synapse,ERBB2, D769Y ,NA,GOF,NA,NA,NA,NA,",23220880,,,,,," +Synapse,ERBB2, D769H ,NA,GOF,NA,NA,NA,NA,",23220880,,,,,," +Synapse,ERBB2,R896C,NA,GOF,NA,NA,NA,NA,",23220880,,,,,," +Synapse,ERBB2,V777L,NA,GOF,NA,NA,NA,NA,",23220880,,,,,," +Synapse,ERBB2,P780_Y781insGSP,NA,GOF,NA,NA,NA,NA,",23220880,,,,,," +Synapse,ERBB2,V842I,NA,GOF,NA,NA,NA,NA,",23220880,,,,,," +Synapse,ERBB2,amplification,NA,GOF,NA,NA,NA,NA,",FDA, 20142587, 22418700, 23632474 ,21558407,21107682, 20975068,26977878,," +Synapse,ERBB2,V659E,NA,GOF,NA,NA,NA,NA,",23950206,,,,,," +Synapse,ERBB2,G309E ,NA,GOF,NA,NA,NA,NA,",22908275,,,,,," +Synapse,ERBB2,S310F,NA,GOF,NA,NA,NA,NA,",22908275,,,,,," +Synapse,ERBB2,S310Y,NA,GOF,NA,NA,NA,NA,",22908275,,,,,," +Synapse,ERBB2,C311R ,NA,GOF,NA,NA,NA,NA,",22908275,,,,,," +Synapse,ERBB2,E321G,NA,GOF,NA,NA,NA,NA,",22908275,,,,,," +Synapse,ERBB2,C334S,NA,GOF,NA,NA,NA,NA,",22908275,,,,,," +Synapse,ERBB2,"S310, L755, V777, P780_Y781insGSP, A775_G776insYVMA",NA,GOF,NA,NA,NA,NA,",AACR 2017 (abstr CT001),,,,,," +Synapse,ERBB2,"A775_G776insYVMA, G776delinsVC, V659E, S310F",NA,GOF,NA,NA,NA,NA,",ASCO 2017 (abstr 8510),,,,,," +Synapse,ERBB2,amplification,NA,GOF,NA,NA,NA,NA,",22586653, 23348520,27108243,http://ascopubs.org/doi/full/10.1200/PO.16.00055, ,,," +Synapse,ERBB2,amplification,NA,GOF,NA,NA,NA,NA,",19840887,25294905,,,,," +Synapse,ERBB2,amplification,NA,GOF,NA,NA,NA,NA,",FDA,AACR 2014 (abstr CT228),24960402,25694417, NCT02015169,,," +Synapse,ERBB2,amplification,NA,GOF,NA,NA,NA,NA,",21380780,,,,,," +Synapse,ERBB2,proximal exon 20 p.775-881,NA,GOF,NA,NA,NA,NA,",26598547, ASCO 2017 (abstr 9071),,,,,," +Synapse,ERBB2,G776L,NA,GOF,NA,NA,NA,NA,",16775247,,,,,," +Synapse,ERBB2,V659E,NA,GOF,NA,NA,NA,NA,",23950206,,,,,," +Synapse,ERBB2,amplification,NA,GOF,NA,NA,NA,NA,",20003286, 12525520,,,,,," +Synapse,ERBB2,amplification,NA,GOF,NA,NA,NA,NA,",27044931,,,,,," +Synapse,ERBB3,G284R,NA,GOF,NA,NA,NA,NA,",ASCO 2015 (abstr e15516),,,,,," +Synapse,ERBB3,R103G,NA,GOF,NA,NA,NA,NA,",ASCO 2015 (abstr e15516),,,,,," +Synapse,ERBB3,P262H,NA,GOF,NA,NA,NA,NA,",23680147,,,,,," +Synapse,ERBB3,G284R,NA,GOF,NA,NA,NA,NA,",23680147,,,,,," +Synapse,ERBB3,Q809R,NA,GOF,NA,NA,NA,NA,",23680147,,,,,," +Synapse,ERBB3,amplification,NA,GOF,NA,NA,NA,NA,",25520391,,,,,," +Synapse,ERBB3,"G284R, V104M, R103G",NA,GOF,NA,NA,NA,NA,",27044931,,,,,," +Synapse,ERBB4,H809G,NA,GOF,NA,NA,NA,NA,",26530965,,,,,," +Synapse,ERBB4,rearrangement,NA,GOF,NA,NA,NA,NA,",24727320,,,,,," +Synapse,ERBB4,E317K,NA,GOF,NA,NA,NA,NA,",19718025,,,,,," +Synapse,ERBB4,E452K,NA,GOF,NA,NA,NA,NA,",19718025,,,,,," +Synapse,ERBB4,E542K,NA,GOF,NA,NA,NA,NA,",19718025,,,,,," +Synapse,ERBB4,R544W,NA,GOF,NA,NA,NA,NA,",19718025,,,,,," +Synapse,ERBB4,R393W,NA,GOF,NA,NA,NA,NA,",19718025,,,,,," +Synapse,ERBB4,E872K,NA,GOF,NA,NA,NA,NA,",19718025,,,,,," +Synapse,ERCC1,any,NA,LOF,NA,NA,NA,NA,",23934192,23275151, 23934192,,,,," +Synapse,ERCC2,any,NA,LOF,NA,NA,NA,NA,",25096233,,,,,," +Synapse,ERCC4,any,NA,LOF,NA,NA,NA,NA,",25634215,,,,,," +Synapse,ERCC6,any ,NA,LOF,NA,NA,NA,NA,",25634215,,,,,," +Synapse,EREG,amplification,NA,GOF,NA,NA,NA,NA,",19738126, 26341080,,,,,," +Synapse,ESR1,ERS1-YAP1 rearrangement,NA,GOF,NA,NA,NA,NA,",24055055,,,,,," +Synapse,ESR1,E380Q,NA,GOF,NA,NA,NA,NA,",24185512, 24185510, 24398047,,,,,," +Synapse,ESR1,"codons 537, 538",NA,GOF,NA,NA,NA,NA,",24185512, 24185510, 24398047,AACR 2015 (abstr CT231),,,,," +Synapse,ESR1,"codons 537, 538",NA,GOF,NA,NA,NA,NA,",27020862,,,,,," +Synapse,ESR1,L536,NA,GOF,NA,NA,NA,NA,",24185512, 24185510,,,,,," +Synapse,ESR1,P535H,NA,GOF,NA,NA,NA,NA,",24185512,,,,,," +Synapse,ESR1,any,NA,GOF,NA,NA,NA,NA,",27269946,27269946,,,,," +Synapse,ESR1,Y537S,NA,GOF,NA,NA,NA,NA,",27986707,,,,,," +Synapse,EZH2,Y641F,NA,GOF,NA,NA,NA,NA,",24563539,,,,,," +Synapse,EZH2,A677,NA,GOF,NA,NA,NA,NA,",23023262,,,,,," +Synapse,FANCA,any,NA,LOF,NA,NA,NA,NA,",26510020,,,,,," +Synapse,FANCC,any,NA,LOF,NA,NA,NA,NA,",26238431,,,,,," +Synapse,FAT1 ,mut,NA,LOF,NA,NA,NA,NA,",27397505,,,,,," +Synapse,FBXW7,any,NA,LOF,NA,NA,NA,NA,",20861909,,,,,," +Synapse,FBXW7,any,NA,LOF,NA,NA,NA,NA,",21368834,,,,,," +Synapse,FGF3,amplification,NA,GOF,NA,NA,NA,NA,",23658459,,,,,," +Synapse,FGF4,amplification,NA,GOF,NA,NA,NA,NA,",23658459,,,,,," +Synapse,FGFR1,amplification,NA,GOF,NA,NA,NA,NA,",25193991,,,,,," +Synapse,FGFR1,amplification,NA,GOF,NA,NA,NA,NA,",27870574,,,,,," +Synapse,FGFR1,amplification,NA,GOF,NA,NA,NA,NA,",ASCO 2017 (abstr 2500),,,,,," +Synapse,FGFR1 ,amplification,NA,GOF,NA,NA,NA,NA,",23418312,,,,,," +Synapse,FGFR2,rearrangement,NA,GOF,NA,NA,NA,NA,",23558953,,,,,," +Synapse,FGFR2,amplification,NA,GOF,NA,NA,NA,NA,",25193991,,,,,," +Synapse,FGFR2,S252W,NA,GOF,NA,NA,NA,NA,",18552176, 22238366, 23002168 ,,,,,," +Synapse,FGFR2,N549K,NA,GOF,NA,NA,NA,NA,",18552176, 22238366, 23002168 ,,,,,," +Synapse,FGFR2,V565I,NA,GOF,NA,NA,NA,NA,",23908597,23908597,ENA 2014 (abstr 381),,,," +Synapse,FGFR2,"M536I, M538I, I548V, N550, E566G, L618M, K660E ",NA,GOF,NA,NA,NA,NA,",23908597,23908597,,,,," +Synapse,FGFR2,amplification,NA,GOF,NA,NA,NA,NA,",ASCO 2015 (abstr 2508),,,,,," +Synapse,FGFR2,P253R,NA,GOF,NA,NA,NA,NA,",23786770,,,,,," +Synapse,FGFR2,A266_S267ins,NA,GOF,NA,NA,NA,NA,",26048680,,,,,," +Synapse,FGFR2,290_291WI>C,NA,GOF,NA,NA,NA,NA,",26048680,,,,,," +Synapse,FGFR2,W290C,NA,GOF,NA,NA,NA,NA,",23786770,,,,,," +Synapse,FGFR2,S320C,NA,GOF,NA,NA,NA,NA,",23786770,,,,,," +Synapse,FGFR2,K660N,NA,GOF,NA,NA,NA,NA,",25035393,,,,,," +Synapse,FGFR2,rearrangement,NA,GOF,NA,NA,NA,NA,",ASCO 2017 (abstr 2500),,,,,," +Synapse,FGFR2,rearrangement,NA,GOF,NA,NA,NA,NA,",ASCO 2016 (abstr 109),,,,,," +Synapse,FGFR2,multiple,NA,GOF,NA,NA,NA,NA,",28034880,,,,,," +Synapse,FGFR2,mut,NA,GOF,NA,NA,NA,NA,",ASCO 2017 (abstr 2500),,,,,," +Synapse,FGFR3,any,NA,GOF,NA,NA,NA,NA,",27870574,,,,,," +Synapse,FGFR3,rearrangement,NA,GOF,NA,NA,NA,NA,",26324363, ASCO 2017 (abstr 2500),,,,,," +Synapse,FGFR3,rearrangement,NA,GOF,NA,NA,NA,NA,",26324363,,,,,," +Synapse,FGFR3,Y373C,NA,GOF,NA,NA,NA,NA,",19331127, 21273588,22869148,,,,," +Synapse,FGFR3,K650,NA,GOF,NA,NA,NA,NA,",19331127, 21273588,16091734, 20439987,,,,," +Synapse,FGFR3,V555M,NA,GOF,NA,NA,NA,NA,",22869148,,,,,," +Synapse,FGFR3,"S249C, G691R",NA,GOF,NA,NA,NA,NA,",27998968,,,,,," +Synapse,FGFR4,N535,NA,GOF,NA,NA,NA,NA,",19809159, 24124571,,,,,," +Synapse,FGFR4,V550,NA,GOF,NA,NA,NA,NA,",19809159, 24124571,,,,,," +Synapse,FLCN,any,NA,LOF,NA,NA,NA,NA,",23995526,,,,,," +Synapse,FLCN,any,NA,LOF,NA,NA,NA,NA,",25295501,,,,,," +Synapse,FLT3,F691,NA,GOF,NA,NA,NA,NA,",22504184,25847190, 25847190,,,,," +Synapse,FLT3,D835,NA,GOF,NA,NA,NA,NA,",22504184,23430109,22368270,20733134,16857985,," +Synapse,FLT3,N676,NA,GOF,NA,NA,NA,NA,",23878140,24619500,,,,," +Synapse,FLT3,Y842,NA,GOF,NA,NA,NA,NA,",22504184,23430109,24619500,,,," +Synapse,FLT3,ITD (Y591-597),NA,GOF,NA,NA,NA,NA,",ASH 2012 (abstr 673), ASH 2012 (abstr 48),16857985,19389879, 22368270,23613521,,," +Synapse,FLT3,"ITD (Y591-597), tyrosine kinase domain (p.610-p.946)",NA,GOF,NA,NA,NA,NA,",ASH 2015,,,,,," +Synapse,FOXA1,amplification,NA,GOF,NA,NA,NA,NA,",27397505,,,,,," +Synapse,FRS2,amplification,NA,GOF,NA,NA,NA,NA,",23393200,,,,,," +Synapse,GATA3,any,NA,GOF,NA,NA,NA,NA,",24758297,,,,,," +Synapse,GNA11,Q209L,NA,GOF,NA,NA,NA,NA,",ASCO 2013 (abstr CRA9003),22733540, 22808163,NCT01587352,,,," +Synapse,GNA11,Q209P,NA,GOF,NA,NA,NA,NA,",ASCO 2013 (abstr CRA9003),22733540, 22808163,NCT01587352,,,," +Synapse,GNAQ,Q209,NA,GOF,NA,NA,NA,NA,",ASCO 2013 (abstr CRA9003),22733540, 22808163,22653968, 22253748 ,NCT01587352,,," +Synapse,GNAS,R201,NA,GOF,NA,NA,NA,NA,",21835143,,,,,," +Synapse,HDAC2,any,NA,LOF,NA,NA,NA,NA,",26510020,,,,,," +Synapse,HGF,amplification,NA,GOF,NA,NA,NA,NA,",22850551,,,,,," +Synapse,HRAS,any,NA,GOF,NA,NA,NA,NA,",22399013, 22507781,,,,,," +Synapse,HRAS,any,NA,GOF,NA,NA,NA,NA,",NCT02383927,,,,,," +Synapse,HRAS,any,NA,GOF,NA,NA,NA,NA,",15950068,22345164,,,,," +Synapse,IDH1,unknown,NA,SOF,NA,NA,NA,NA,",ENA 2014 (abstr 1LBA),25599133,,,,," +Synapse,IDH1,R132H,NA,SOF,NA,NA,NA,NA,",23558169,,,,,," +Synapse,IDH1,R132,NA,GOF,NA,NA,NA,NA,",27231123,,,,,," +Synapse,IDH1,R132,NA,GOF,NA,NA,NA,NA,",28148839,,,,,," +Synapse,IDH2,R140Q,NA,SOF,NA,NA,NA,NA,",AACR 2014 (abstr CT103),,,,,," +Synapse,IDH2,R172K,NA,SOF,NA,NA,NA,NA,",AACR 2014 (abstr CT103),,,,,," +Synapse,IDH2,R172,NA,GOF,NA,NA,NA,NA,",27231123,,,,,," +Synapse,IGF1R,amplification,NA,GOF,NA,NA,NA,NA,",24458568,,,,,," +Synapse,IGF2,amplification,NA,GOF,NA,NA,NA,NA,",25632036,,,,,," +Synapse,IL7R ,237-255_indel or S185C,NA,GOF,NA,NA,NA,NA,",22897847, 22955920,22955920,,,,," +Synapse,INI1,any,NA,LOF,NA,NA,NA,NA,",ENA 2014 (abstr 6LBA), ESMO 2015 (abstract 302),,,,,," +Synapse,INPP4B,any,NA,LOF,NA,NA,NA,NA,",23551093,,,,,," +Synapse,JAK1,S646F,NA,GOF,NA,NA,NA,NA,",22955920,,,,,," +Synapse,JAK1,any,NA,LOF,NA,NA,NA,NA,",27433843,,,,,," +Synapse,JAK1,any,NA,LOF,NA,NA,NA,NA,",27903500,,,,,," +Synapse,JAK2,rearrangement,NA,GOF,NA,NA,NA,NA,",22875628, 22899477 ,,,,,," +Synapse,JAK2,R683,NA,GOF,NA,NA,NA,NA,",18805579, 22955920,,,,,," +Synapse,JAK2,V617F,NA,GOF,NA,NA,NA,NA,",22422826,22829971,,,,," +Synapse,JAK2,V617F,NA,GOF,NA,NA,NA,NA,",FDA,,,,,," +Synapse,JAK2,amplification,NA,GOF,NA,NA,NA,NA,",27075627,,,,,," +Synapse,JAK2,any,NA,LOF,NA,NA,NA,NA,",27433843,,,,,," +Synapse,JAK3,R657Q,NA,GOF,NA,NA,NA,NA,",18397343,,,,,," +Synapse,JAK3,I87T,NA,GOF,NA,NA,NA,NA,",18397343,,,,,," +Synapse,JAK3,Q501H,NA,GOF,NA,NA,NA,NA,",18397343,,,,,," +Synapse,JAK3 ,A572V,NA,GOF,NA,NA,NA,NA,",22705984,,,,,," +Synapse,JAK3 ,A573V,NA,GOF,NA,NA,NA,NA,",22705984,,,,,," +Synapse,KDR,A1065T,NA,GOF,NA,NA,NA,NA,",24569783,,,,,," +Synapse,KIT,N822K,NA,GOF,NA,NA,NA,NA,",23149070,,,,,," +Synapse,KIT,exon 8 p.416-422,NA,GOF,NA,NA,NA,NA,",15618474,,,,,," +Synapse,KIT,D816V,NA,GOF,NA,NA,NA,NA,",18986703,,,,,," +Synapse,KIT,"V559I, H687Y, T670, V654A, A829P, D816, N822, Y823D",NA,GOF,NA,NA,NA,NA,",23582185, 21689725, 17259998,,,,,," +Synapse,KIT,exon 9 p.449-514,NA,GOF,NA,NA,NA,NA,",FDA,18955458, 18955451, 16624552,22270258,21737509,,," +Synapse,KIT,exon 11 p.550-592,NA,GOF,NA,NA,NA,NA,",FDA,18955458,22270258,22898035,25239608, ASCO 2015 (abstr 10535),," +Synapse,KIT,exon 14 p.664-714,NA,GOF,NA,NA,NA,NA,",FDA,18955458,,,,," +Synapse,KIT,exon 17 p.788-828,NA,GOF,NA,NA,NA,NA,",FDA,23840364,22119758, 21456006,23840364,21737509,," +Synapse,KIT,"exon 17 p.788-828, exon 18 p.829-860",NA,GOF,NA,NA,NA,NA,",ASCO 2015 (abstr 10517),,,,,," +Synapse,KIT,T670I,NA,GOF,NA,NA,NA,NA,",24687822,,,,,," +Synapse,KIT,"A82P9, V654A, T670I",NA,GOF,NA,NA,NA,NA,",25239608,,,,,," +Synapse,KIT,"exon 11 p.550-592, exon 13 p.627-664 ",NA,GOF,NA,NA,NA,NA,",NCCN,18421059, 21642685, 21690468, 22261812 ,19671763,18936790,22068222, 25695690,," +Synapse,KIT,amplification,NA,GOF,NA,NA,NA,NA,",23775962,22261812,,,,," +Synapse,KIT,"exon 17 p.788-828, exon 18 p.829-860",NA,GOF,NA,NA,NA,NA,",21690468, 21642685,20372153,,,,," +Synapse,KIT,D820Y,NA,GOF,NA,NA,NA,NA,",23775962,25695690,,,,," +Synapse,KIT,Y553N,NA,GOF,NA,NA,NA,NA,",21969494,23375402,,,,," +Synapse,KIT,D820E,NA,GOF,NA,NA,NA,NA,",19461405,,,,,," +Synapse,KIT,del577-578–579,NA,GOF,NA,NA,NA,NA,",20970876,,,,,," +Synapse,KIT,V560del,NA,GOF,NA,NA,NA,NA,",15201427,,,,,," +Synapse,KIT,H697Y,NA,GOF,NA,NA,NA,NA,",19861435,,,,,," +Synapse,KIT ,exon 13 p.627-664,NA,GOF,NA,NA,NA,NA,",FDA,18955458,,,,," +Synapse,KIT ,wild type,NA,NA,NA,NA,NA,NA,",18955458,18955458,ASCO 2011 (abstr 10009),16397263,,," +Synapse,KIT ,D816V,NA,GOF,NA,NA,NA,NA,",18559612,,,,,," +Synapse,KRAS,any,NA,GOF,NA,NA,NA,NA,",20921461,23200175, 24947927, 25667274, 25722381,26802155,25516890,AACR 2016 (abstr LB214),emerging,emerging" +Synapse,KRAS,G12,NA,GOF,NA,NA,NA,NA,",18701506,,,,,," +Synapse,KRAS,any,NA,GOF,NA,NA,NA,NA,",22507781,,,,,," +Synapse,KRAS,any,NA,GOF,NA,NA,NA,NA,",23391555,,,,,," +Synapse,KRAS,any,NA,GOF,NA,NA,NA,NA,",22169769,27167191,,,,," +Synapse,KRAS,wild type,NA,NA,NA,NA,NA,NA,",FDA,,,,,," +Synapse,KRAS,any,NA,GOF,NA,NA,NA,NA,",FDA,24163374,24553387,22392911,23245996,emerging ," +Synapse,KRAS,amplification,NA,GOF,NA,NA,NA,NA,",ENA 2014 (abstr 428),,,,,," +Synapse,KRAS,any,NA,GOF,NA,NA,NA,NA,",22614881, 22290393,,,,,," +Synapse,KRAS,G12,NA,GOF,NA,NA,NA,NA,",24687822,,,,,," +Synapse,KRAS,any,NA,GOF,NA,NA,NA,NA,",25294897,,,,,," +Synapse,KRAS,any,NA,GOF,NA,NA,NA,NA,",22985491,,,,,," +Synapse,KRAS,any,NA,GOF,NA,NA,NA,NA,",23583440,ASCO 2015 (abstr 4119),,,,," +Synapse,KRAS,any,NA,GOF,NA,NA,NA,NA,",AACR 2016 (abstr CT005), AACR 2017 (abstr CT002),22662154,21984976, 22662154,,,," +Synapse,KRAS,G13D,NA,GOF,NA,NA,NA,NA,",27114605,,,,,," +Synapse,KRAS ,any,NA,GOF,NA,NA,NA,NA,",25500057, 25516890,19018267,25968887,,,," +Synapse,LRP1B ,any,NA,LOF,NA,NA,NA,NA,",22896685,,,,,," +Synapse,MAP2K1,I99T,NA,GOF,NA,NA,NA,NA,",19915144,,,,,," +Synapse,MAP2K1,L115,NA,GOF,NA,NA,NA,NA,",19915144,,,,,," +Synapse,MAP2K1,G128D,NA,GOF,NA,NA,NA,NA,",19915144,,,,,," +Synapse,MAP2K1,F129L,NA,GOF,NA,NA,NA,NA,",19915144,23614898,,,,," +Synapse,MAP2K1,V211D,NA,GOF,NA,NA,NA,NA,",19915144,,,,,," +Synapse,MAP2K1,L215P,NA,GOF,NA,NA,NA,NA,",19915144,23614898,,,,," +Synapse,MAP2K1,I103N,NA,GOF,NA,NA,NA,NA,",19915144,23614898,,,,," +Synapse,MAP2K1,K104N,NA,GOF,NA,NA,NA,NA,",19915144,,,,,," +Synapse,MAP2K1,I111N,NA,GOF,NA,NA,NA,NA,",19915144,,,,,," +Synapse,MAP2K1,H119P,NA,GOF,NA,NA,NA,NA,",19915144,,,,,," +Synapse,MAP2K1,E120D,NA,GOF,NA,NA,NA,NA,",19915144,,,,,," +Synapse,MAP2K1,F133L,NA,GOF,NA,NA,NA,NA,",19915144,,,,,," +Synapse,MAP2K1,Q56P,NA,GOF,NA,NA,NA,NA,",26582713,,,,,," +Synapse,MAP2K1,P124,NA,GOF,NA,NA,NA,NA,",19915144,23614898,,,,," +Synapse,MAP2K1,D67N,NA,GOF,NA,NA,NA,NA,",19915144,,,,,," +Synapse,MAP2K1,unknown,NA,GOF,NA,NA,NA,NA,",26030179,,,,,," +Synapse,MAP2K1,K57T,NA,GOF,NA,NA,NA,NA,",26644315,,,,,," +Synapse,MAP2K1,P124L,NA,GOF,NA,NA,NA,NA,",19915144,,,,,," +Synapse,MAP2K1,P124S,NA,GOF,NA,NA,NA,NA,",22588879,,,,,," +Synapse,MAP2K1,P124,NA,GOF,NA,NA,NA,NA,",25370473,25370473,,,,," +Synapse,MAP2K1,I111S,NA,GOF,NA,NA,NA,NA,",22588879,,,,,," +Synapse,MAP2K1,K57E,NA,GOF,NA,NA,NA,NA,",23569304,,,,,," +Synapse,MAP2K1,K57N,NA,GOF,NA,NA,NA,NA,",23444215,,,,,," +Synapse,MAP2K1,C121S,NA,GOF,NA,NA,NA,NA,",21383288,24448821,,,,," +Synapse,MAP2K1,E203K,NA,GOF,NA,NA,NA,NA,",23569304,19915144,,,,," +Synapse,MAP2K1,Q56P,NA,GOF,NA,NA,NA,NA,",23569304,,,,,," +Synapse,MAP2K1,Q56_V60del,NA,GOF,NA,NA,NA,NA,",26324360,,,,,," +Synapse,MAP2K2,Q60P,NA,GOF,NA,NA,NA,NA,",24265154,24265154,,,,," +Synapse,MAP2K2,"V35M, L46F, N126D, C125S",NA,GOF,NA,NA,NA,NA,",24265153,24265153,,,,," +Synapse,MCL1,amplification,NA,GOF,NA,NA,NA,NA,",21368834,,,,,," +Synapse,MDM2,amplification,NA,GOF,NA,NA,NA,NA,",27646943,,,,,," +Synapse,MDM2,amplification,NA,GOF,NA,NA,NA,NA,",23084521, ASCO 2015 (abstr 10564),,,,,," +Synapse,MDM4,amplification,NA,GOF,NA,NA,NA,NA,",24336067,,,,,," +Synapse,MET,amplification,NA,GOF,NA,NA,NA,NA,",23729478,ENA 2015 (abstract A52),27397505,27325282,27325282,," +Synapse,MET,rearrangement,NA,GOF,NA,NA,NA,NA,",27748748,,,,,," +Synapse,MET,exon 16-19 p.1132-1330,NA,GOF,NA,NA,NA,NA,",AACR 2016 (abstr CT2006),,,,,," +Synapse,MET,amplification,NA,GOF,NA,NA,NA,NA,",23213094, AACR 2016 (abstr CT2006),,,,,," +Synapse,MET,amplification,NA,GOF,NA,NA,NA,NA,",22850551,,,,,," +Synapse,MET,V1110I,NA,GOF,NA,NA,NA,NA,",17483355,,,,,," +Synapse,MET,H1112R,NA,GOF,NA,NA,NA,NA,",17483355,,,,,," +Synapse,MET,M1250I,NA,GOF,NA,NA,NA,NA,",17483355,,,,,," +Synapse,MET,R988C,NA,GOF,NA,NA,NA,NA,",17483355,,,,,," +Synapse,MET,T1010I,NA,GOF,NA,NA,NA,NA,",17483355,,,,,," +Synapse,MET,Y1230C,NA,GOF,NA,NA,NA,NA,",17483355,,,,,," +Synapse,MET,Y1235D,NA,GOF,NA,NA,NA,NA,",17483355,,,,,," +Synapse,MET,H1112L,NA,GOF,NA,NA,NA,NA,",AACR 2012 (abstr 1786),,,,,," +Synapse,MET,amplification,NA,GOF,NA,NA,NA,NA,",26432108,,,,,," +Synapse,MET,amplification,NA,GOF,NA,NA,NA,NA,",ASCO GI 2015 (abstr 1),22729845, 23327903,22238368,,,," +Synapse,MET,amplification,NA,GOF,NA,NA,NA,NA,",22162573,,,,,," +Synapse,MET,amplification,NA,GOF,NA,NA,NA,NA,",ENA 2015 (abstract A55),,,,,," +Synapse,MET,amplification,NA,GOF,NA,NA,NA,NA,",ASCO 2014 (abstr 8001), ASCO 2015 (abstr 2595),ASCO 2015 (abstr 8089),,,,," +Synapse,MET,M1268T,NA,GOF,NA,NA,NA,NA,",23610116,,,,,," +Synapse,MET,H1094R,NA,GOF,NA,NA,NA,NA,",23213094,,,,,," +Synapse,MET,kinase domain,NA,GOF,NA,NA,NA,NA,",28644771,,,,,," +Synapse,MET,kinase domain,NA,GOF,NA,NA,NA,NA,",28644771,,,,,," +Synapse,MET,kinase domain,NA,GOF,NA,NA,NA,NA,",28644771,,,,,," +Synapse,MET,D1228V,NA,GOF,NA,NA,NA,NA,",27694386,,,,,," +Synapse,MET,exon 14 skipping,NA,GOF,NA,NA,NA,NA,",ASCO 2016 (abstr 108), ASCO 2017 (abstr 8511),25971938, 26215952 ,,,,," +Synapse,MGMT,any,NA,LOF,NA,NA,NA,NA,",15758010,,,,,," +Synapse,MITF,amplification,NA,GOF,NA,NA,NA,NA,",24265153,,,,,," +Synapse,MLL ,rearrangement,NA,GOF,NA,NA,NA,NA,",22417203,22015773,21741596,21964340,,," +Synapse,MLL2,mut,NA,LOF,NA,NA,NA,NA,",27397505,,,,,," +Synapse,MPL,W515F,NA,GOF,NA,NA,NA,NA,",16834459,,,,,," +Synapse,MSH3,any,NA,LOF,NA,NA,NA,NA,",24556366,,,,,," +Synapse,MTOR,I1973F,NA,GOF,NA,NA,NA,NA,",26859683,,,,,," +Synapse,MTOR,I1973F,NA,GOF,NA,NA,NA,NA,",ASCO 2015 (abstr 11010),,,,,," +Synapse,MTOR,E2014K,NA,GOF,NA,NA,NA,NA,",24625776,,,,,," +Synapse,MTOR,E2419K,NA,GOF,NA,NA,NA,NA,",24625776,,,,,," +Synapse,MTOR,N1421D,NA,GOF,NA,NA,NA,NA,",ASCO 2015 (abstr 11010),,,,,," +Synapse,MTOR,L1460P,NA,GOF,NA,NA,NA,NA,",24631838,,,,,," +Synapse,MTOR,S2215Y,NA,GOF,NA,NA,NA,NA,",24631838,,,,,," +Synapse,MTOR,R2505P,NA,GOF,NA,NA,NA,NA,",24631838,,,,,," +Synapse,MTOR,F2108L,NA,GOF,NA,NA,NA,NA,",25295501,25295501,,,,," +Synapse,MTOR,K1771R,NA,GOF,NA,NA,NA,NA,",ASCO 2015 (abstr 11010),,,,,," +Synapse,MTOR,Q2223K,NA,GOF,NA,NA,NA,NA,",24622468,,,,,," +Synapse,MTOR,N1421D,NA,GOF,NA,NA,NA,NA,",26859683,,,,,," +Synapse,MTOR,K1771R,NA,GOF,NA,NA,NA,NA,",26859683,,,,,," +Synapse,MYC,amplification,NA,GOF,NA,NA,NA,NA,",21889194,,,,,," +Synapse,MYC,amplification,NA,GOF,NA,NA,NA,NA,",26537256,23430699,25416950,,,," +Synapse,MYC,amplification,NA,GOF,NA,NA,NA,NA,",25505253,,,,,," +Synapse,MYC,amplification,NA,GOF,NA,NA,NA,NA,",27397505,,,,,," +Synapse,MYD88,L265P,NA,GOF,NA,NA,NA,NA,",25853747,,,,,," +Synapse,MYD88,L265P,NA,GOF,NA,NA,NA,NA,",26244327,21179087,,,,," +Synapse,NF1,any,NA,LOF,NA,NA,NA,NA,",ASCO 2016 (abstr 105),24576830,23288408, 24576830,23444215, 23288408,,," +Synapse,NF1,any,NA,LOF,NA,NA,NA,NA,",ASCO 2016 (abstr 11053),18483311, 20505189, 24509877,23221341,21907929,,," +Synapse,NF1,any,NA,LOF,NA,NA,NA,NA,",19573811,,,,,," +Synapse,NF1,D1644A,NA,LOF,NA,NA,NA,NA,",26859683,,,,,," +Synapse,NF1,mut,NA,LOF,NA,NA,NA,NA,",24931142,,,,,," +Synapse,NF2,any,NA,LOF,NA,NA,NA,NA,",25567352,,,,,," +Synapse,NF2,any,NA,LOF,NA,NA,NA,NA,",25878190,,,,,," +Synapse,NF2,any,NA,LOF,NA,NA,NA,NA,",19451225, 22426462, 22927055 ,,,,,," +Synapse,NF2,any,NA,LOF,NA,NA,NA,NA,",ENA 2012 (abstr 610),,,,,," +Synapse,NF2,any,NA,LOF,NA,NA,NA,NA,",22805104,,,,,," +Synapse,NF2,any,NA,LOF,NA,NA,NA,NA,",22844108,,,,,," +Synapse,NF2,any,NA,LOF,NA,NA,NA,NA,",23960073,,,,,," +Synapse,NOTCH1,rearrangement,NA,GOF,NA,NA,NA,NA,",16688224, 23033986 ,,,,,," +Synapse,NOTCH1,PEST domain p.2245-2536,NA,GOF,NA,NA,NA,NA,",27870570,,,,,," +Synapse,NOTCH1,PEST domain p.2245-2536,NA,GOF,NA,NA,NA,NA,",ASCO 2006 (abstr 6585),15472075, 19778842, 22510873, 23001755,19246562,19318552,20861909, 20861920, 20944675,," +Synapse,NOTCH1,HD p.1529-1723,NA,GOF,NA,NA,NA,NA,",ASCO 2006 (abstr 6585),15472075, 19778842, 22510873, 23001755 ,19246562,19318552,20861909, 20861920, 20944675,," +Synapse,NOTCH1,rearrangement,NA,GOF,NA,NA,NA,NA,",22101766,,,,,," +Synapse,NOTCH1,PEST domain p.2245-2536,NA,GOF,NA,NA,NA,NA,",25564152,,,,,," +Synapse,NOTCH1,any,NA,GOF,NA,NA,NA,NA,",22210878,,,,,," +Synapse,NOTCH2,PEST domain p.2010-2472,NA,GOF,NA,NA,NA,NA,",25564152,,,,,," +Synapse,NOTCH2,rearrangement,NA,GOF,NA,NA,NA,NA,",22101766,,,,,," +Synapse,NPM1,any,NA,LOF,NA,NA,NA,NA,",22417203,19059939,27535106,,,," +Synapse,NRAS,any,NA,GOF,NA,NA,NA,NA,",23414587, ASCO 2016 (abstr 9500),18390968, 22761467,ASCO 2014 (abstr 9009),ESMO 2015 (abstract 300), AACR 2017 (abstr CT002),23538902,emerging ," +Synapse,NRAS,any,NA,GOF,NA,NA,NA,NA,",18701506,,,,,," +Synapse,NRAS,any,NA,GOF,NA,NA,NA,NA,",22507781,,,,,," +Synapse,NRAS,G12C,NA,GOF,NA,NA,NA,NA,",23614898,,,,,," +Synapse,NRAS,any,NA,GOF,NA,NA,NA,NA,",24024839, 20619739, 23325582 ,23274911, 22392911 ,,,,," +Synapse,NRAS,any,NA,GOF,NA,NA,NA,NA,",25294897,,,,,," +Synapse,NRAS,any,NA,GOF,NA,NA,NA,NA,",23515407,,,,,," +Synapse,NRAS,any,NA,GOF,NA,NA,NA,NA,",22985491,,,,,," +Synapse,NRG1,rearrangement,NA,GOF,NA,NA,NA,NA,",AACR 2016 (abstr 2631),24727320,,,,," +Synapse,NTRK1,"G595R, G667C",NA,GOF,NA,NA,NA,NA,",26546295,,,,,," +Synapse,NTRK1,rearrangement,NA,GOF,NA,NA,NA,NA,",26546295,,,,,," +Synapse,NTRK1,rearrangement,NA,GOF,NA,NA,NA,NA,",ASCO 2013 (abstr 8023),24162815,,,,," +Synapse,NTRK1,rearrangement,NA,GOF,NA,NA,NA,NA,",28183697, ASCO 2017 (LBA2501),,,,,," +Synapse,NTRK3,rearrangement,NA,GOF,NA,NA,NA,NA,",AACR 2016 (abstr CT008),,,,,," +Synapse,NTRK3,rearrangement,NA,GOF,NA,NA,NA,NA,",21148487, 23131561,,,,,," +Synapse,PAK1,amplification,NA,GOF,NA,NA,NA,NA,",23535073,,,,,," +Synapse,PALB2,any,NA,LOF,NA,NA,NA,NA,",21135251,25719666,25263539, NCT01585805,,,," +Synapse,PALB2,any,NA,LOF,NA,NA,NA,NA,",AACR 2015 (abstr CT322), 26510020,,,,,," +Synapse,PBRM1,any,NA,LOF,NA,NA,NA,NA,",26552009,,,,,," +Synapse,PDGFRA,"R748G,Y894C",NA,GOF,NA,NA,NA,NA,",NCCN,,,,,," +Synapse,PDGFRA,amplification,NA,GOF,NA,NA,NA,NA,",23544171,,,,,," +Synapse,PDGFRA,T674I,NA,GOF,NA,NA,NA,NA,",12660384,,,,,," +Synapse,PDGFRA,rearrangement,NA,GOF,NA,NA,NA,NA,",FDA,,,,,," +Synapse,PDGFRA,"P577S, R841K, H845Y, G853D",NA,GOF,NA,NA,NA,NA,",24132921,,,,,," +Synapse,PDGFRA,rearrangement,NA,GOF,NA,NA,NA,NA,",FDA,,,,,," +Synapse,PDGFRA ,D842V,NA,GOF,NA,NA,NA,NA,",22718859, 16638875,ASCO 2016 (abstr 11010),18794084,18794084,,," +Synapse,PDGFRA ,exon 12 p.552-596,NA,GOF,NA,NA,NA,NA,",NCCN,,,,,," +Synapse,PDGFRA ,exon 14 p.631-668,NA,GOF,NA,NA,NA,NA,",NCCN,,,,,," +Synapse,PDGFRA ,exon 18 p.814-854,NA,GOF,NA,NA,NA,NA,",NCCN,,,,,," +Synapse,PDGFRA ,wild type,NA,NA,NA,NA,NA,NA,",14645423, 18955458,18955458,ASCO 2011 (abstr 10009),16397263,,," +Synapse,PDGFRA ,V658A,NA,GOF,NA,NA,NA,NA,",24132921,24132921,,,,," +Synapse,PDPK1,amplification,NA,GOF,NA,NA,NA,NA,",19602588,,,,,," +Synapse,PIK3CA,any,NA,GOF,NA,NA,NA,NA,",22271473, 27672108,,,,,," +Synapse,PIK3CA,any,NA,GOF,NA,NA,NA,NA,",ASCO 2015 (abstr 2516),,,,,," +Synapse,PIK3CA,amplification,NA,GOF,NA,NA,NA,NA,",24366379,,,,,," +Synapse,PIK3CA,any,NA,GOF,NA,NA,NA,NA,",22271473, ASCO 2013 (abstr 2531),,,,,," +Synapse,PIK3CA,any ,NA,GOF,NA,NA,NA,NA,",23094721,19223544, 20619739,23475782, 22392911 ,,,," +Synapse,PIK3CA,any,NA,GOF,NA,NA,NA,NA,",ASCO 2015 (abstr 2501),,,,,," +Synapse,PIK3CA, any,NA,GOF,NA,NA,NA,NA,",19671762,,,,,," +Synapse,PIK3CA,any,NA,GOF,NA,NA,NA,NA,",26787751, 26763254 ,,,,,," +Synapse,PIK3CA,any ,NA,GOF,NA,NA,NA,NA,",ASCO 2017 (abstr 9054),,,,,," +Synapse,PIK3CA,any,NA,GOF,NA,NA,NA,NA,",22271473, AACR 2013 (abstr LB-66), 25231405,,,,,," +Synapse,PIK3CA,any,NA,GOF,NA,NA,NA,NA,",21289267,,,,,," +Synapse,PIK3CA,any,NA,GOF,NA,NA,NA,NA,",28331003,22271473,27091708,ASCO 2015 (abstr 2500),,," +Synapse,PIK3CB,D1067Y,NA,GOF,NA,NA,NA,NA,",26759240,26759240,,,,," +Synapse,PIK3CB,any,NA,GOF,NA,NA,NA,NA,",23619167,,,,,," +Synapse,PIK3R1,any,NA,LOF,NA,NA,NA,NA,",ASCO 2015 (abstr 11075),,,,,," +Synapse,PIK3R1,any,NA,LOF,NA,NA,NA,NA,",23166678,,,,,," +Synapse,PIK3R2,A171V,NA,LOF,NA,NA,NA,NA,",21984976, 19962665 , ,,,,," +Synapse,PIK3R2,N561D,NA,LOF,NA,NA,NA,NA,",21984976,,,,,," +Synapse,PLCG2,"R665W, L845F",NA,GOF,NA,NA,NA,NA,",24869598,,,,,," +Synapse,PML-RARA,rearrangement,NA,GOF,NA,NA,NA,NA,",FDA,,,,,," +Synapse,POLE,exonuclease domain,NA,GOF,NA,NA,NA,NA,",27001570, 27683556,,,,,," +Synapse,POLE,exonuclease domain,NA,GOF,NA,NA,NA,NA,",27159395,,,,,," +Synapse,POLE,any,NA,LOF,NA,NA,NA,NA,",28188185,,,,,," +Synapse,PRKCH,amplification,NA,GOF,NA,NA,NA,NA,",25186176,,,,,," +Synapse,PTCH1,any,NA,LOF,NA,NA,NA,NA,",19726763,,,,,," +Synapse,PTCH1,any,NA,LOF,NA,NA,NA,NA,",19726761,25391241,,,,," +Synapse,PTEN,any,NA,LOF,NA,NA,NA,NA,",http://ascopubs.org/doi/abs/10.1200/PO.16.00054,23039341,26645196,,,," +Synapse,PTEN,any,NA,LOF,NA,NA,NA,NA,",23085766, 22932669,,,,,," +Synapse,PTEN,any,NA,LOF,NA,NA,NA,NA,",ASCO 2013 (abstr 2532),,,,,," +Synapse,PTEN,any,NA,LOF,NA,NA,NA,NA,",21163703, 19398573 ,,,,,," +Synapse,PTEN,any,NA,LOF,NA,NA,NA,NA,",21468130, 20944090,21788564, 23238879 ,22662154,,,," +Synapse,PTEN,any,NA,LOF,NA,NA,NA,NA,",21325073, 21191045, 17804702,,,,,," +Synapse,PTEN,any,NA,LOF,NA,NA,NA,NA,",23136191,,,,,," +Synapse,PTEN,any,NA,LOF,NA,NA,NA,NA,",21632463,21632463,,,,," +Synapse,PTEN,any,NA,LOF,NA,NA,NA,NA,",22025163,,,,,," +Synapse,PTEN,any,NA,LOF,NA,NA,NA,NA,",23582881,21575859,ASCO 2014 (abstr 2514^),,,," +Synapse,PTEN,any,NA,LOF,NA,NA,NA,NA,",21289267,,,,,," +Synapse,PTEN,any,NA,LOF,NA,NA,NA,NA,",25409150,27091708,27397505,,,," +Synapse,PTEN ,any,NA,LOF,NA,NA,NA,NA,",21673091, 23287563, 21998291 ,,,,,," +Synapse,PTPRD,mut,NA,GOF,NA,NA,NA,NA,",23800680,,,,,," +Synapse,RAC1,P29S,NA,GOF,NA,NA,NA,NA,",25056119,,,,,," +Synapse,RAD50,L1237F,NA,LOF,NA,NA,NA,NA,",24934408,,,,,," +Synapse,RAD51C,any,NA,LOF,NA,NA,NA,NA,",ASCO 2015 (abstr 5508),,,,,," +Synapse,RAF1,S257P,NA,GOF,NA,NA,NA,NA,",23737487,,,,,," +Synapse,RAF1,P261P,NA,GOF,NA,NA,NA,NA,",23737487,,,,,," +Synapse,RAF1,G361A,NA,GOF,NA,NA,NA,NA,",23737487,,,,,," +Synapse,RAF1,rearrangement,NA,GOF,NA,NA,NA,NA,",20526349,,,,,," +Synapse,RB1,any,NA,LOF,NA,NA,NA,NA,",26238431,,,,,," +Synapse,RB1,any,NA,LOF,NA,NA,NA,NA,", 17080083, 21515735,18483379,,,,," +Synapse,RET,rearrangement,NA,GOF,NA,NA,NA,NA,",28447912,26787234,,,,," +Synapse,RET,I788N,NA,GOF,NA,NA,NA,NA,",28615362,,,,,," +Synapse,RET,"codon 618, 620, 634, 768, 791, 891, 918",NA,GOF,NA,NA,NA,NA,",20065189, 22025146,,,,,," +Synapse,RET,C634W,NA,GOF,NA,NA,NA,NA,",20065189, 22025146,21470995,23056499,,,," +Synapse,RET,M918T,NA,GOF,NA,NA,NA,NA,",20065189, 22025146,21470995,23056499,,,," +Synapse,RET-PTC1,rearrangement,NA,GOF,NA,NA,NA,NA,",21470995,23056499,,,,," +Synapse,RICTOR,amplification,NA,GOF,NA,NA,NA,NA,",26370156,,,,,," +Synapse,RNF43,any,NA,GOF,NA,NA,NA,NA,",ENA 2015 (abstract C45),,,,,," +Synapse,RNF43,any,NA,GOF,NA,NA,NA,NA,",27869803,,,,,," +Synapse,ROS1,rearrangement,NA,GOF,NA,NA,NA,NA,",24875859,,,,,," +Synapse,ROS1,rearrangement,NA,GOF,NA,NA,NA,NA,",FDA,27370605,23533265,,,," +Synapse,ROS1,G2032R,NA,GOF,NA,NA,NA,NA,",23724914, 25688157,25351743,,,,," +Synapse,ROS1,"S1986Y, S1986F",NA,GOF,NA,NA,NA,NA,",27401242,27401242,,,,," +Synapse,SERPINB3,mut,NA,LOF,NA,NA,NA,NA,",27668655,,,,,," +Synapse,SETD2,any,NA,LOF,NA,NA,NA,NA,",ENA 2014 (abstr 211),,,,,," +Synapse,SF3B1,"K700E, K666N",NA,GOF,NA,NA,NA,NA,",ENA 2014 (abstr 456), ENA 2014 (abstr 575), 25424858,,,,,," +Synapse,SH2B3,any,NA,LOF,NA,NA,NA,NA,",20404132,,,,,," +Synapse,SMARCA1,any,NA,LOF,NA,NA,NA,NA,",26552009,,,,,," +Synapse,SMARCA4,any,NA,LOF,NA,NA,NA,NA,",ESMO 2015 (abstract 302),,,,,," +Synapse,SMARCB1,mut,NA,LOF,NA,NA,NA,NA,",26920892,,,,,," +Synapse,SMO,"G497W, D473Y",NA,GOF,NA,NA,NA,NA,",25306392,,,,,," +Synapse,SMO,D473H,NA,GOF,NA,NA,NA,NA,",19726788, 25759019 ,,,,,," +Synapse,SMO,P641A,NA,GOF,NA,NA,NA,NA,",ASCO 2017 (abstr 9062),,,,,," +Synapse,SOCS1,any,NA,LOF,NA,NA,NA,NA,",22025331,,,,,," +Synapse,SRSF2,any,NA,LOF,NA,NA,NA,NA,",27135740,,,,,," +Synapse,STAG2,any,NA,LOF,NA,NA,NA,NA,",24356817,,,,,," +Synapse,STK11,any,NA,LOF,NA,NA,NA,NA,",19541609,,,,,," +Synapse,STK11,any,NA,LOF,NA,NA,NA,NA,",19165201,22425996,23352126,19165201,20541700,," +Synapse,STK11,D194E,NA,LOF,NA,NA,NA,NA,",21189378,,,,,," +Synapse,SUZ12,any,NA,LOF,NA,NA,NA,NA,",25119042,,,,,," +Synapse,SYK,amplification,NA,GOF,NA,NA,NA,NA,",16409295, 19549911,,,,,," +Synapse,TMPRSS2,rearrangement,NA,GOF,NA,NA,NA,NA,",21575865,21575865, ,,,," +Synapse,TOP2A,amplification,NA,GOF,NA,NA,NA,NA,",22864769,,,,,," +Synapse,TP53,mut,NA,LOF,NA,NA,NA,NA,",27217383,,,,,," +Synapse,TP53,mut,NA,LOF,NA,NA,NA,NA,",27646943,,,,,," +Synapse,TP53,mut,NA,LOF,NA,NA,NA,NA,",27959731,,,,,," +Synapse,TP53,mut,NA,LOF,NA,NA,NA,NA,",27959731,,,,,," +Synapse,TP53,"R248Q, R175H",NA,GOF,NA,NA,NA,NA,",26009011,,,,,," +Synapse,TP53,any,NA,LOF,NA,NA,NA,NA,",25125259,,,,,," +Synapse,TP53,any,NA,GOF,NA,NA,NA,NA,",ASCO2015 (abstr 2507),,,,,," +Synapse,TP53,any,NA,LOF,NA,NA,NA,NA,",25409149,,,,,," +Synapse,TP53,mut,NA,LOF,NA,NA,NA,NA,",27397505,,,,,," +Synapse,TP53,wild type,NA,LOF,NA,NA,NA,NA,",AACR 2017 (abstr CT152),,,,,," +Synapse,TRKA,G595R,NA,GOF,NA,NA,NA,NA,",28578312,,,,,," +Synapse,TRKC ,G623R,NA,GOF,NA,NA,NA,NA,",28578312,28578312,,,,," +Synapse,TSC1,any,NA,LOF,NA,NA,NA,NA,",26859683,,,,,," +Synapse,TSC1,any,NA,LOF,NA,NA,NA,NA,",24622468, 26859683, ASCO 2015 (abstr 11010), ASCO 2015 (abstr 4519),,,,,," +Synapse,TSC1,any,NA,LOF,NA,NA,NA,NA,",23312829, 21525172, 20048174,,,,,," +Synapse,TSC1,any,NA,LOF,NA,NA,NA,NA,",22923433,,,,,," +Synapse,TSC1,any,NA,GOF,NA,NA,NA,NA,",27016228,,,,,," +Synapse,TSC2,any,NA,LOF,NA,NA,NA,NA,",26859683,,,,,," +Synapse,TSC2,any,NA,LOF,NA,NA,NA,NA,",23312829, 21525172, 20048174,,,,,," +Synapse,TSC2,any,NA,LOF,NA,NA,NA,NA,",24691995,,,,,," +Synapse,TSC2,any,NA,LOF,NA,NA,NA,NA,",25295501,,,,,," +Synapse,TSC2,any,NA,GOF,NA,NA,NA,NA,",27016228,,,,,," +Synapse,U2AF1,mut,NA,LOF,NA,NA,NA,NA,",27397505,,,,,," +Synapse,VEGFA,amplification,NA,GOF,NA,NA,NA,NA,",24687604,,,,,," +Synapse,ZNRF3,any,NA,GOF,NA,NA,NA,NA,",26023187,,,,,," +Docm,MTOR,I2500M,NA,NA,NA,NA,NA,NA,26619011 +Docm,MTOR,C1483W,NA,NA,NA,NA,NA,NA,26619011 +Docm,NRAS,Q61R,NA,NA,NA,NA,NA,NA,"19075190,16434492,26619011,19773371,23515407,2674680,21305640,2278970,19255327,22761467,21107323,23406027,20619739,20130576,21729679,23614898,3122217,18390968,18948947,8120410,23538902,16273091,25157968,17384584,20736745,20179705,17699718,23569304,21829508,16291983,21576590,12460918,22407852,23414587" +Docm,NRAS,Q61P,NA,NA,NA,NA,NA,NA,"26619011,23414587,23569304,23614898,24370118,8120410,20130576,22761467,18390968,23538902,2674680,20179705,25157968,16291983" +Docm,NRAS,Q61*,NA,NA,NA,NA,NA,NA,"23076151,25157968" +Docm,NRAS,Q61K,NA,NA,NA,NA,NA,NA,"26619011,23414587,18390968,21829508,16273091,2674680,20619739,21305640,19255327,19773371,23614898,17384584,8120410,20130576,20736745,21729679,18948947,12460918,22761467,23538902,26821351,23515407,17699718,23569304,16291983,21107323,23406027,20179705,19657110" +Docm,CTNNB1,VSHWQQQSYLDSGIHSG22-,NA,NA,NA,NA,NA,NA,25157968 +Candl,ABL1,T212R,NA,NA,NA,NA,NA,NA,20519627 +Candl,ABL1,T212R,NA,NA,NA,NA,NA,NA,20519627 +Candl,AKT1,0,NA,NA,NA,NA,NA,NA, +Candl,AKT1,E17K,NA,NA,NA,NA,NA,NA,"17611497, 23134728" +Candl,ARAF,F351L,NA,NA,NA,NA,NA,NA,24652991 +Candl,BRAF,0,NA,NA,NA,NA,NA,NA, diff --git a/oncoKB_tmp.csv b/oncoKB_tmp.csv old mode 100644 new mode 100755 index 174b2af..9924720 --- a/oncoKB_tmp.csv +++ b/oncoKB_tmp.csv @@ -1,3702 +1,3701 @@ -Gene Alteration Oncogenicity Mutation Effect PMIDs for Mutation Effect Abstracts for Mutation Effect -FAM58A Truncating Mutations Likely Oncogenic Likely Loss-of-function 24218572, 18297069 -CBL H94Y Inconclusive Inconclusive 20126411, 26676746 -CBL M374V Likely Neutral Likely Neutral 26676746 -CBL R420Q Oncogenic Loss-of-function 25178484, 17446348, 19387008, 19734451 -CBL V391I Likely Oncogenic Loss-of-function 26676746 -CBL Deletion Likely Oncogenic Likely Loss-of-function 19276253, 19901108, 22315494 -CBL W802* Likely Oncogenic Likely Gain-of-function 20126411 -CBL Y371H Oncogenic Loss-of-function 23696637, 26676746 -CBL V430M Likely Neutral Likely Neutral 26676746 -CBL H398Y Likely Oncogenic Loss-of-function 19387008 -CBL Y371S Oncogenic Loss-of-function 19620960 -CBL K382E Likely Oncogenic Loss-of-function 25178484, 26676746 -CBL Truncating Mutations Likely Oncogenic Likely Loss-of-function 20508043, 20694012, 22315494 -CBL S376F Likely Oncogenic Loss-of-function 19387008 -CBL P417A Likely Oncogenic Loss-of-function 19387008 -CBL P428L Likely Neutral Likely Neutral 26676746 -CBL C381A Likely Oncogenic Loss-of-function 25178484, 26676746 -CBL C396R Likely Oncogenic Loss-of-function 26676746 -CBL S80N Inconclusive Inconclusive 20126411, 26676746 -CBL G375P Likely Oncogenic Loss-of-function 26676746 -CBL P395A Likely Oncogenic Loss-of-function 26676746 -CBL H398Q Likely Oncogenic Loss-of-function 26676746 -CBL D390Y Likely Oncogenic Loss-of-function 25178484 -CBL L399V Likely Oncogenic Loss-of-function 26676746 -CBL C384R Oncogenic Loss-of-function 23696637 -CBL Q367P Oncogenic Loss-of-function 19620960 -CBL N454D Likely Neutral Neutral 19387008 -CBL Q249E Likely Oncogenic Likely Gain-of-function 20126411 -SHOC2 M173I Likely Oncogenic Loss-of-function 25137548 -SHOC2 S2G Likely Oncogenic Loss-of-function 19684605, 23918763 -TERT H412Y Likely Oncogenic Loss-of-function 18042801 -TERT Promoter Mutations Oncogenic Gain-of-function 23348506, 23348503, 23887589, 24657534, 25048572, 23530248 -TERT P704S Likely Oncogenic Loss-of-function 18042801 -TERT Y846C Likely Oncogenic Loss-of-function 18042801 -TERT C250T Oncogenic Gain-of-function 23348506, 23348503, 23887589, 26389665, 24657534, 23530248 -TERT Amplification Likely Oncogenic Likely Gain-of-function 25219713, 18482052, 25301727 -TERT H876Q Likely Oncogenic Loss-of-function 18042801 -TERT C228T Oncogenic Gain-of-function 23348506, 23348503, 23887589, 24657534, 23530248 -DICER1 E1705K Likely Oncogenic Loss-of-function 22187960 -DICER1 E1705A Likely Oncogenic Loss-of-function 17920623 -DICER1 D1709N Oncogenic Loss-of-function 26033159, 22187960 -DICER1 D1709A Likely Oncogenic Likely Loss-of-function 22187960 -DICER1 Truncating Mutations Likely Oncogenic Likely Loss-of-function 20305640, 22133720, 21501861, 22353998, 21266384 -DICER1 D1709E Likely Oncogenic Likely Loss-of-function 22187960 -DICER1 D1810A Likely Oncogenic Loss-of-function 17920623 -DICER1 G1809K Likely Oncogenic Loss-of-function 26033159 -DICER1 G1809R Oncogenic Loss-of-function 26033159 -DICER1 Deletion Likely Oncogenic Likely Loss-of-function 20305640, 26513514, 27295554, 19903759, 22353998 -PTPRT T844M Likely Oncogenic Loss-of-function 24493670 -PTPRT A1022E Oncogenic Loss-of-function 24395800 -PTPRT R1343L Likely Oncogenic Loss-of-function 15155950 -PTPRT A707T Likely Oncogenic Likely Loss-of-function 20230342 -PTPRT Q984K Likely Oncogenic Loss-of-function 15155950, 22389709 -PTPRT N1125I Likely Oncogenic Loss-of-function 15155950, 22389709 -PTPRT Y412F Likely Oncogenic Likely Loss-of-function 20230342 -PTPRT Y280H Likely Oncogenic Likely Loss-of-function 18644975 -PTPRT L708P Likely Oncogenic Likely Loss-of-function 20230342 -PTPRT R1040L Oncogenic Likely Loss-of-function 24395800 -PTPRT A209T Likely Oncogenic Likely Loss-of-function 18644975 -PTPRT F74S Likely Oncogenic Likely Loss-of-function 15155950, 18644975 -PTPRT V648G Likely Oncogenic Likely Loss-of-function 20230342 -PTPRT R453C Likely Oncogenic Likely Loss-of-function 20230342 -PTPRT Promoter Hypermethylation Oncogenic Loss-of-function 25009298, 25982282, 23096495 -PTPRT Q479E Likely Oncogenic Likely Loss-of-function 20230342 -PTPRT S492F Likely Oncogenic Likely Loss-of-function 20230342 -PTPRT T1365M Likely Oncogenic Loss-of-function 15155950 -PTPRT F248S Likely Oncogenic Likely Loss-of-function 18644975 -PTPRT N510K Likely Oncogenic Likely Loss-of-function 20230342 -PTPRT V995M Likely Oncogenic Loss-of-function 24317090, 17360477 -PTPRT Truncating Mutations Likely Oncogenic Likely Loss-of-function 15155950, 20133777, 21517784 -PTPRT K218T Likely Oncogenic Likely Loss-of-function 18644975 -PTPRT T605M Likely Oncogenic Likely Loss-of-function 20230342 -PTPRT R1209W Likely Oncogenic Loss-of-function 15155950 -PTPRT D927G Likely Oncogenic Loss-of-function 22389709 -RHEB Y35H Likely Oncogenic Gain-of-function 24631838, 22819219 -RHEB Y35C Oncogenic Gain-of-function 24631838, 22819219 -RHEB Y35N Oncogenic Gain-of-function 24631838, 27399332, 22819219, 26255626 -SHQ1 Deletion Likely Oncogenic Likely Loss-of-function 19383767, 19019820, 20579941 -SHQ1 Truncating Mutations Likely Oncogenic Likely Loss-of-function -CCND2 Amplification Likely Oncogenic Likely Gain-of-function 8114739 -RAD50 L234fs Likely Oncogenic Likely Loss-of-function 16474176, 14684699, 16385572 -RAD50 Deletion Likely Oncogenic Likely Loss-of-function 12208847, 2659437, 14684699, 15309560 -RAD50 L1273F Likely Oncogenic Loss-of-function 24934408 -RAD50 Truncating Mutations Likely Oncogenic Likely Loss-of-function 12208847, 16288216, 21892167, 14684699 -CCND3 Amplification Likely Oncogenic Likely Gain-of-function 8114739 -CCND3 D286_L292trunc Likely Oncogenic Likely Gain-of-function 9832503 -CCND3 I290R Likely Oncogenic Likely Gain-of-function 2876518, 24913233, 22885699 -CCND3 T283A Likely Oncogenic Gain-of-function 2876518, 24913233, 22885699 -CCND3 T286A Likely Oncogenic Gain-of-function 9832503 -CCND3 I290A Likely Oncogenic Likely Gain-of-function 9832503 -CCND3 P284L Likely Oncogenic Likely Gain-of-function 2876518, 24913233, 22885699 -CCND3 Q276* Likely Oncogenic Gain-of-function 2876518, 24913233, 22885699 -RIT1 A77P Oncogenic Gain-of-function 24469055 -RIT1 A77T Likely Oncogenic Likely Gain-of-function 26714497 -RIT1 M90I Oncogenic Gain-of-function 24469055 -RIT1 A77S Oncogenic Gain-of-function 24469055 -CCNE1 Amplification Oncogenic Gain-of-function 8618861, 15838514, 12845634, 24605326 -CCNE1 Overexpression Oncogenic Gain-of-function 8618861, 15838514, 12845634, 24605326 -RYBP Truncating Mutations Likely Oncogenic Likely Loss-of-function 19098711 -TGFBR1 C41Y Likely Oncogenic Loss-of-function 21358634 -TGFBR1 N45S Likely Oncogenic Loss-of-function 21358634, 23358096 -TGFBR1 R487Q Likely Oncogenic Likely Loss-of-function 16928994, 25116393, 16791849 -TGFBR1 S241L Likely Oncogenic Likely Loss-of-function 16791849 -TGFBR1 G52R Likely Oncogenic Loss-of-function 21358634, 23358096 -TGFBR1 Truncating Mutations Likely Oncogenic Likely Loss-of-function 10656986, 11212236 -TGFBR1 S387Y Likely Oncogenic Loss-of-function 9809982 -TGFBR1 P83L Likely Oncogenic Loss-of-function 21358634 -TGFBR1 TGFBR1*6A Likely Oncogenic Loss-of-function 17848956, 10582683, 20429896, 16204663, 19882361, 22905183 -TGFBR2 R537P Likely Oncogenic Likely Gain-of-function 18339844 -TGFBR2 P525L Likely Oncogenic Loss-of-function 7862150 -TGFBR2 D404G Likely Oncogenic Loss-of-function 8668164 -TGFBR2 Deletion Likely Oncogenic Likely Loss-of-function 27558455, 25521327, 25736321 -TGFBR2 E526Q Likely Oncogenic Loss-of-function 18339844, 10789724 -TGFBR2 Truncating Mutations Likely Oncogenic Likely Loss-of-function 16310402, 17456004, 17985359, 9927040, 11309634, 7585632 -MSH6 T1219I Likely Oncogenic Likely Loss-of-function 11709755, 24362816, 22102614, 23621914 -MSH6 S144I Likely Neutral Likely Neutral 21120944 -MSH6 R1076C Likely Oncogenic Likely Loss-of-function 21056691, 19072991 -MSH6 Deletion Likely Oncogenic Likely Loss-of-function 25255306, 24090359, 21970482, 12019211, 22781090 -MSH6 F1088Sfs*2 Oncogenic Loss-of-function 9808525, 11474654, 19254532, 9331106 -MSH6 R1095H Likely Neutral Likely Neutral 22581703, 24040339, 12522549, 23621914 -MSH6 F1088Lfs*5 Oncogenic Loss-of-function 12732731, 11474654, 10959092, 9510473, 19254532, 21637783 -MSH6 Truncating Mutations Likely Oncogenic Likely Loss-of-function 9822680, 9111312, 1651234, 9564049 -MSH6 R976H Likely Oncogenic Likely Loss-of-function 11709755, 24362816, 11807791, 18790734 -MSH6 V509A Likely Neutral Likely Neutral 24362816 -MSH6 R922* Oncogenic Loss-of-function 24362816, 19254532 -MSH6 E946* Oncogenic Loss-of-function 12732731, 22810696, 19254532 -MSH6 E1322* Oncogenic Loss-of-function 24755471, 22810696, 19254532 -MSH6 G39E Likely Neutral Likely Neutral 24362816 -KMT2D Deletion Likely Oncogenic Likely Loss-of-function 24633898, 24240169, 26366712 -KMT2D Truncating Mutations Likely Oncogenic Likely Loss-of-function 24633898, 24240169, 26366712 -LATS1 Truncating Mutations Likely Oncogenic Loss-of-function 9988269, 23230145, 11850843 -LATS1 Deletion Likely Oncogenic Likely Loss-of-function 9988269, 23573293, 26040669 -PBRM1 Deletion Likely Oncogenic Likely Loss-of-function 18339845, 21248752, 23867514, 22949125 -PBRM1 N1333Gfs* Oncogenic Loss-of-function 25911086 -PBRM1 Truncating Mutations Likely Oncogenic Likely Loss-of-function 18339845, 24613357, 21248752, 22949125, 21654818 -SF3B1 H662D Likely Oncogenic Switch-of-function 25428262 -SF3B1 R625D Likely Oncogenic Switch-of-function 24434863 -SF3B1 G742D Likely Oncogenic Switch-of-function 24434863, 25428262, 21909114 -SF3B1 R625G Likely Oncogenic Switch-of-function 25788694, 26565915 -SF3B1 K666M Likely Oncogenic Switch-of-function 24434863 -SF3B1 R625C Likely Oncogenic Switch-of-function 24434863, 26565915, 23861464 -SF3B1 K666R Oncogenic Switch-of-function 25428262, 21909114 -SF3B1 R957Q Likely Oncogenic Switch-of-function 23160465 -SF3B1 K700R Likely Oncogenic Likely Switch-of-function 24434863, 26565915, 26619011, 25428262 -SF3B1 R625H Likely Oncogenic Switch-of-function 24434863, 26565915, 23861464 -SF3B1 H662Q Likely Oncogenic Switch-of-function 25428262, 21909114 -SF3B1 R625L Likely Oncogenic Switch-of-function 24434863, 26565915, 23861464 -SF3B1 K700E Likely Oncogenic Switch-of-function 25424858, 24434863, 26565915, 24854990, 23335386, 25428262, 23160465, 27622333, 21909114 -SF3B1 E622Q Likely Oncogenic Switch-of-function 26565915, 25428262, 21909114 -SF3B1 K666N Likely Oncogenic Switch-of-function 24434863, 25788694 -SF3B1 H662R Likely Oncogenic Switch-of-function 25428262, 21909114 -SF3B1 E622D Likely Oncogenic Switch-of-function 25428262, 21909114 -SF3B1 K666T Likely Oncogenic Switch-of-function 24434863, 26842708 -LATS2 Deletion Oncogenic Loss-of-function 21245096 -EGFR V769_D770insGVV Oncogenic Gain-of-function 23371856, 19536777, 24353160, 21764376, 18676761, 15897572, 17686547, 17192902 -EGFR L703P Likely Oncogenic Likely Gain-of-function 19020901 -EGFR S720P Likely Oncogenic Likely Gain-of-function 22760226, 15897572 -EGFR S784F Likely Oncogenic Gain-of-function 20522446, 21531810, 19147750, 21841502 -EGFR Exon 19 insertion Oncogenic Gain-of-function 21422421, 22190593 -EGFR L858Q Likely Oncogenic Likely Gain-of-function 24743239 -EGFR Exon 19 deletion Oncogenic Gain-of-function 15329413, 18000506, 15118125, 19536777, 18458038, 15118073, 22019513, 23566546, 23559152, 24457318, 22760226, 23749122, 17192902 -EGFR D770_N771insVDSVDNP Oncogenic Gain-of-function 23371856, 19536777, 24353160, 21764376, 18676761, 15897572, 21841502, 17686547 -EGFR K745_A750del Oncogenic Gain-of-function 15118073, 15329413, 25179728, 15118125 -EGFR T710A Likely Oncogenic Likely Gain-of-function 23912954 -EGFR H773dup Oncogenic Gain-of-function 24353160 -EGFR G863S Likely Oncogenic Likely Gain-of-function 18000506 -EGFR Y727H Likely Oncogenic Likely Gain-of-function 18000506 -EGFR E884K Oncogenic Gain-of-function 16407879, 19015641 -EGFR T790M Oncogenic Gain-of-function 15728811, 18227510, 15737014 -EGFR G796S Likely Oncogenic Gain-of-function 18193092 -EGFR L747V Likely Oncogenic Likely Gain-of-function 23242437, 22190593 -EGFR H773L Oncogenic Gain-of-function 17974985 -EGFR R841K Likely Neutral Likely Loss-of-function 18193092 -EGFR E746V Likely Oncogenic Likely Gain-of-function 16467085, 18000506 -EGFR S768_D770dup Oncogenic Gain-of-function 23371856, 19536777, 24353160, 21764376, 18676761, 23749122, 15897572, 17686547 -EGFR H870R Likely Neutral Likely Neutral 19671738, 21841502 -EGFR P691S Likely Oncogenic Likely Gain-of-function 22483783, 18000506 -EGFR L858M Likely Oncogenic Likely Gain-of-function 25232377 -EGFR R108K Oncogenic Gain-of-function 24120142, 17177598 -EGFR E746Q Likely Oncogenic Likely Gain-of-function 16467085 -EGFR L747_E749del Oncogenic Gain-of-function 16467085, 15118073, 15329413, 25179728, 15118125 -EGFR E709Q Likely Oncogenic Likely Gain-of-function 19671738, 15897572 -EGFR I744_K745delinsKIPVAI Oncogenic Gain-of-function 15118073, 15329413, 21841502, 15118125 -EGFR V726M Likely Oncogenic Likely Gain-of-function 18000506 -EGFR W731L Likely Oncogenic Gain-of-function 20942962 -EGFR A750_E758delinsP Oncogenic Gain-of-function 15118073, 15329413, 18261621, 15118125 -EGFR S464L Likely Oncogenic Likely Gain-of-function 25633215 -EGFR V774M Likely Oncogenic Likely Gain-of-function 21531810 -EGFR S921R Likely Neutral Inconclusive 19020901 -EGFR A763_Y764insFQEA Oncogenic Gain-of-function 24353160 -EGFR P753S Likely Oncogenic Likely Gain-of-function 16467085, 16106023, 25130612, 24934779 -EGFR N826Y Likely Oncogenic Likely Gain-of-function 21531810, 19147750 -EGFR S752_I759del Likely Oncogenic Likely Gain-of-function 23371856, 19536777, 24353160, 21764376, 18676761, 15897572, 17686547, 17192902 -EGFR E746_S752delinsI Oncogenic Gain-of-function 15118073, 15329413, 15118125, 17192902 -EGFR E709V Likely Oncogenic Likely Gain-of-function 21531810, 19536777, 26051236 -EGFR G465E Likely Oncogenic Likely Gain-of-function 26416732 -EGFR L861F Likely Oncogenic Likely Gain-of-function 21531810, 19536777, 19147750, 17177598, 26051236, 21252719 -EGFR S768I Oncogenic Gain-of-function 19536777, 16205628, 25521406, 25521405, 23242437, 19147750, 18676761, 23912954, 25179728, 25130612 -EGFR E709G Likely Oncogenic Likely Gain-of-function 21531810, 26051236, 23912954 -EGFR L747_T751del Oncogenic Gain-of-function 18325048, 23242437, 15118073, 15329413, 23387505, 15897572, 15118125 -EGFR E866K Likely Neutral Loss-of-function 19147750 -EGFR L747_S752del Oncogenic Gain-of-function 16467085, 15118073, 15329413, 15118125, 17192902 -EGFR G719S Oncogenic Gain-of-function 21531810, 16187797, 26206867 -EGFR A767_V769dup Oncogenic Gain-of-function 23371856, 19536777, 24353160, 21764376, 18676761, 23912954, 23749122, 15897572, 17686547 -EGFR L861P Likely Oncogenic Likely Gain-of-function 21531810, 17177598, 18000506 -EGFR L858R Oncogenic Gain-of-function 15118073, 15329413, 15118125 -EGFR L838P Likely Oncogenic Likely Gain-of-function 21531810 -EGFR L747P Oncogenic Gain-of-function 21531810, 18508816, 19536777, 26339441, 26001153, 22190593 -EGFR Fusions Likely Oncogenic Likely Gain-of-function 27102076, 23917401 -EGFR D761N Likely Oncogenic Gain-of-function 19147750, 26870223 -EGFR K467T Likely Oncogenic Likely Gain-of-function 25633215 -EGFR G465R Likely Oncogenic Likely Gain-of-function 26416732 -EGFR T785A Likely Oncogenic Gain-of-function 20942962 -EGFR E746_S752delinsV Oncogenic Gain-of-function 15118073, 15329413, 22483783, 25179728, 15710947, 15118125 -EGFR E330K Oncogenic Gain-of-function 24212795 -EGFR E734Q Likely Oncogenic Gain-of-function 20942962 -EGFR T725M Likely Oncogenic Gain-of-function 24743239 -EGFR D761Y Likely Oncogenic Likely Gain-of-function 17973572, 17545553, 19632948, 17085664, 17192902 -EGFR EGFRvV Oncogenic Gain-of-function 17189397, 1730638, 2790960 -EGFR EGFRvIII Oncogenic Gain-of-function 8895767, 17189397, 19324552, 8052651, 23777544, 12438278 -EGFR L861Q Oncogenic Gain-of-function 21531810, 18508816, 16467085, 17177598, 25668120, 21841502, 15897572, 21252719, 19536777, 18325048, 19147750, 26051236, 18676761, 23912954, 24457318, 22760226, 20808254, 23749122, 24285021 -EGFR P772_V774dup Oncogenic Gain-of-function 23371856, 19536777, 24353160, 21764376, 18676761, 25179728, 15897572, 17686547 -EGFR G719C Likely Oncogenic Likely Gain-of-function 21531810, 15118073, 19147750, 18261621, 26206867, 21841502 -EGFR A767_V769del Likely Oncogenic Likely Gain-of-function 23371856, 19536777, 24353160, 21764376, 18676761, 15897572, 17686547 -EGFR E746G Likely Oncogenic Likely Gain-of-function 21531810 -EGFR T34_A289del Oncogenic Gain-of-function 27216155 -EGFR G735S Oncogenic Gain-of-function 18193092, 25435280 -EGFR S768_V769insVAS Oncogenic Gain-of-function 23371856, 19536777, 24353160, 21764376, 18676761, 15897572, 21841502, 17686547 -EGFR H773insLGNP Oncogenic Gain-of-function 23371856, 19536777, 24353160, 21764376, 18676761, 23749122, 15897572, 17686547 -EGFR EGFRvII Oncogenic Gain-of-function 24893890, 17189397 -EGFR G810S Likely Oncogenic Gain-of-function 19147750 -EGFR L861R Oncogenic Gain-of-function 21531810, 17177598, 24743239, 21841502, 21252719 -EGFR R776H Likely Oncogenic Gain-of-function 23242437, 20512075, 23358982 -EGFR E746_S752delinsA Oncogenic Gain-of-function 15118073, 15329413, 15710947, 15118125 -EGFR E746_A750del Oncogenic Gain-of-function 18508816, 18325048, 16467085, 15118073, 15329413, 18261621, 22483783, 25179728, 16373402, 15710947, 15897572, 15118125 -EGFR T263P Oncogenic Gain-of-function 17177598 -EGFR G724S Oncogenic Gain-of-function 16166444, 24894453, 24743239 -EGFR S645C Likely Oncogenic Likely Gain-of-function 27478040 -EGFR H773Y Likely Oncogenic Likely Gain-of-function 19536777, 17974985, 18676761 -EGFR V843I Likely Oncogenic Gain-of-function 23380224, 21172876, 19536777, 25057940, 18000506, 18355544 -EGFR V774A Likely Oncogenic Likely Gain-of-function 21531810 -EGFR G863D Likely Oncogenic Gain-of-function 17376509, 16204011, 15897572 -EGFR S492R Likely Oncogenic Likely Switch-of-function 22270724 -EGFR Exon 19 deletion/insertion Oncogenic Gain-of-function 15329413, 18000506, 15118125, 19536777, 18458038, 15118073, 22019513, 23566546, 23559152, 24457318, 22760226, 23749122, 17192902 -EGFR C620Y Oncogenic Gain-of-function 24747966 -EGFR G857E Likely Oncogenic Likely Gain-of-function 23139256, 18000506, 19238633, 25435280 -EGFR P772_H773insYNP Oncogenic Gain-of-function 23371856, 19536777, 24353160, 21764376, 18676761, 15897572, 17686547 -EGFR A289V Oncogenic Gain-of-function 24120142, 17177598, 22588883 -EGFR D770_N771insSVD Oncogenic Gain-of-function 23371856, 19536777, 24353160, 21764376, 18676761, 15897572, 17686547 -EGFR E746_T751insIP Oncogenic Gain-of-function 18325048, 22190593 -EGFR EGFR-RAD51 Fusion Oncogenic Gain-of-function 27102076 -EGFR V742A Likely Oncogenic Gain-of-function 21531810, 23605641, 19147750, 16152581 -EGFR A864T Oncogenic Gain-of-function 23585556, 19147750, 21761100, 22722798, 16551849 -EGFR I941R Likely Neutral Likely Loss-of-function 24063894 -EGFR EGFR-KDD Oncogenic Gain-of-function 26286086 -EGFR E758G Likely Oncogenic Likely Gain-of-function 19536777 -EGFR V769M Likely Oncogenic Likely Gain-of-function 21531810, 23749122 -EGFR L704N Likely Neutral Loss-of-function 24063894 -EGFR L747S Likely Oncogenic Likely Gain-of-function 17973572, 18309959, 18645621, 19632948, 18981003 -EGFR R776C Likely Oncogenic Gain-of-function 19147750 -EGFR E746_T751delinsL Oncogenic Gain-of-function 15118073, 15329413, 18261621, 15118125 -EGFR K745M Likely Neutral Loss-of-function 21081186 -EGFR I853T Likely Neutral Loss-of-function 19147750 -EGFR P848L Likely Neutral Likely Neutral 23897956, 22848293, 25176975, 23912954, 17877814 -EGFR L747_P753del Oncogenic Gain-of-function 15118073, 15329413, 25179728, 15118125 -EGFR D770_N771insNPG Oncogenic Gain-of-function 23371856, 19536777, 24353160, 21764376, 18676761, 15897572, 17686547 -EGFR I491M Likely Oncogenic Likely Neutral 25633215 -EGFR N826S Oncogenic Gain-of-function 19147750, 15897572 -EGFR E709_T710delinsD Oncogenic Gain-of-function 21531810, 26206867 -EGFR V769_D770insASV Oncogenic Gain-of-function 23371856, 19536777, 24353160, 21764376, 18676761, 15897572, 17686547 -EGFR EGFR-PURB Fusion Likely Oncogenic Likely Gain-of-function 27102076 -EGFR L692F Likely Oncogenic Likely Gain-of-function 23912954 -EGFR E746_A750delinsQ Oncogenic Gain-of-function 15118073, 15329413, 15118125, 17192902 -EGFR G719A Oncogenic Gain-of-function 21531810, 26206867 -EGFR L747_A750del Oncogenic Gain-of-function 16467085, 15118073, 15329413, 15118125 -EGFR L838V Likely Oncogenic Gain-of-function 19147750 -EGFR E709A Likely Oncogenic Gain-of-function 21531810, 19671738, 23242437, 18261621, 23566546, 22483783, 23749122, 20479403, 15710947, 18372921, 21841502 -EGFR Exon 20 insertion Oncogenic Gain-of-function 23371856, 19536777, 24353160, 21764376, 18676761, 15897572, 17686547 -EGFR E868G Likely Oncogenic Gain-of-function 20942962, 16870303 -EGFR E746_T751delinsVA Oncogenic Gain-of-function 18508816, 15118073, 15329413, 15897572, 15118125 -EGFR E804G Likely Oncogenic Gain-of-function 18193092 -EGFR K806A Likely Oncogenic Likely Gain-of-function 19536777 -EGFR H773_V774insH Oncogenic Gain-of-function 24353160 -EGFR Y801H Likely Oncogenic Gain-of-function 20942962, 17224267 -EGFR D837N Likely Oncogenic Likely Gain-of-function 23749122 -EGFR D587H Likely Oncogenic Gain-of-function 26571394, 27245685 -EGFR N771_H773dup Oncogenic Gain-of-function 23371856, 19536777, 24353160, 21764376, 18676761, 23912954, 15897572, 17686547 -EGFR E746_T751delinsA Oncogenic Gain-of-function 15118073, 15329413, 15710947, 15897572, 15118125 -EGFR R836C Likely Oncogenic Likely Gain-of-function 23912954 -EGFR G598V Oncogenic Gain-of-function 24120142, 17177598, 22588883 -EGFR R324L Oncogenic Gain-of-function 24212795 -EGFR A750_E758del Oncogenic Gain-of-function 18325048, 15118073, 15329413, 15118125 -EGFR D770_N771insD Oncogenic Gain-of-function 23371856, 19536777, 24353160, 21764376, 18676761, 15897572, 17686547 -EGFR L747F Likely Oncogenic Likely Gain-of-function 16533793, 26773740, 24385129, 23485129, 26096169, 22190593 -EGFR L747_P753delinsS Oncogenic Gain-of-function 18508816, 15118073, 15329413, 19147750, 25179728, 15710947, 15897572, 15118125 -EGFR Amplification Oncogenic Gain-of-function 24120142, 10728703 -EGFR A859_L883delinsV Likely Oncogenic Likely Gain-of-function 18325048 -EGFR A750P Oncogenic Gain-of-function 19625781, 25179728, 15737014, 16187797 -EGFR E709K Oncogenic Gain-of-function 19726454, 23566546, 18000506, 25179728, 25130612, 23749122, 15710947, 26206867 -EGFR C797Y Likely Oncogenic Gain-of-function 20942962 -EGFR V765A Likely Oncogenic Likely Gain-of-function 15897572 -EGFR P596L Likely Oncogenic Likely Gain-of-function 17177598, 23243055 -EGFR G719D Likely Oncogenic Likely Gain-of-function 21531810, 18000506, 26206867 -EGFR L747_T751delinsP Oncogenic Gain-of-function 15118073, 15329413, 15710947, 15118125 -EGFR T783A Likely Oncogenic Likely Gain-of-function 18676761, 15897572 -EGFR L833V Oncogenic Gain-of-function 16205628, 21949883, 23912954, 25130612, 20808254, 21422421 -EGFR EGFRvIV Oncogenic Gain-of-function 20676128, 23007009 -EGFR D770_P772dup Oncogenic Gain-of-function 23371856, 19536777, 24353160, 21764376, 18676761, 23749122, 15897572, 17686547 -EGFR C628Y Likely Neutral Neutral 24747966 -EGFR L747_A750delinsP Oncogenic Gain-of-function 18508816, 15118073, 15329413, 15118125, 17192902 -EGFR V851A Likely Neutral Loss-of-function 19147750 -NKX2-1 Amplification Oncogenic Gain-of-function 17925434, 18212743, 22439932 -NKX2-1 Fusions Likely Oncogenic Likely Gain-of-function 21481790 -NKX2-1 A339V Likely Oncogenic Gain-of-function 19176457 -NKX2-1 TRB-NKX2-1 Fusion Likely Oncogenic Likely Gain-of-function 21481790 -NKX2-1 IGH-NKX2 Fusion Likely Oncogenic Likely Gain-of-function 21481790 -NKX2-1 TRA-NKX2-1 Fusion Likely Oncogenic Likely Gain-of-function 21481790 -EIF1AX A113_splice Oncogenic Gain-of-function 26878173 Krishnamoorthy et al. Abstract# 892, AACR 2016 http://cancerres.aacrjournals.org/content/76/14_Supplement/892 -ARID2 Truncating Mutations Likely Oncogenic Likely Loss-of-function 23047306, 21822264, 15985610, 16847454 -ARID2 Deletion Likely Oncogenic Likely Loss-of-function 23047306, 22095441, 15985610, 16847454 -BRD4 BRD4-NUT Fusion Oncogenic Gain-of-function 23604113, 21447744, 25512383, 20676058, 17934517, 20871596 -BRD4 Fusions Oncogenic Likely Gain-of-function 12543779, 23128391, 25564152 -BRD4 Amplification Likely Oncogenic Gain-of-function 12192049, 19596781, 15456879 -HIST1H1C S102F Likely Oncogenic Likely Loss-of-function 24362818 -ERRFI1 Deletion Likely Oncogenic Likely Loss-of-function 16648858, 21113414 -ERRFI1 Truncating Mutations Likely Oncogenic Likely Loss-of-function -CHEK2 R117G Likely Oncogenic Loss-of-function 16835864, 16982735 -CHEK2 I157T Inconclusive Inconclusive 16816021, 11571648, 15239132, 11053450, 14612911, 15492928, 11298456, 12049740 -CHEK2 H371Y Likely Oncogenic Loss-of-function 21618645, 25884806 -CHEK2 E321K Likely Oncogenic Loss-of-function 16835864 -CHEK2 K373E Oncogenic Loss-of-function 27716909 -CHEK2 S428F Likely Oncogenic Likely Loss-of-function 16998506, 15649950 -CHEK2 P85L Likely Neutral Neutral 16998506, 15649950 -CHEK2 E161del Likely Oncogenic Loss-of-function 16982735 -PAK1 Amplification Oncogenic Gain-of-function 21482786, 22105362 -TMPRSS2 TMPRSS2-ERG Fusion Oncogenic Gain-of-function 7731694, 16213704, 17043636 -TMPRSS2 Fusions Likely Oncogenic Likely Gain-of-function 16254181, 18283340 -TMPRSS2 T75M Likely Neutral Neutral 11745466, 25040002 -TMPRSS2 TMPRSS2-ETV5 Fusion Likely Oncogenic Likely Gain-of-function 18172298 -TMPRSS2 TMPRSS2-ETV4 Fusion Likely Oncogenic Likely Gain-of-function 16585160 -TMPRSS2 M160V Likely Neutral Neutral 11745466, 25040002 -TMPRSS2 TMPRSS2-ETV1 Fusion Oncogenic Gain-of-function 18563191, 23512661 -H3F3A K28M Likely Oncogenic Likely Switch-of-function 21685365, 22286061 -H3F3A G35V Likely Oncogenic Likely Switch-of-function 21685365, 23079654, 22286061 -H3F3A G35R Likely Oncogenic Likely Switch-of-function 21685365, 23079654, 22286061 -ELF3 I279P Likely Oncogenic Likely Loss-of-function 17148437 -ELF3 Truncating Mutations Likely Oncogenic Likely Loss-of-function 14976186, 17148437 -ELF3 K320E Likely Neutral Likely Neutral 17148437 -ELF3 A312P Likely Oncogenic Likely Loss-of-function 17148437 -ELF3 S330A Likely Neutral Likely Neutral 17148437 -ELF3 S308A Likely Neutral Likely Neutral 17148437 -ELF3 R331P Likely Oncogenic Likely Loss-of-function 17148437 -ROS1 S1986F Likely Oncogenic Likely Gain-of-function 27401242 -ROS1 ROS1-CD74 Fusion Oncogenic Gain-of-function 22919003, 22215748, 18083107, 22327623 -ROS1 CEP85L-ROS1 Fusion Likely Oncogenic Likely Gain-of-function 25204415, 23637631 -ROS1 E1935G Likely Oncogenic Likely Gain-of-function 24218589 -ROS1 FIG-ROS1 Fusion Oncogenic Gain-of-function 12661006, 2827175 -ROS1 G2101A Likely Oncogenic Likely Gain-of-function 22235099, 25688157, 24675041 -ROS1 KDELR2-ROS1 Fusion Likely Oncogenic Likely Gain-of-function 22980976 -ROS1 G1971E Likely Oncogenic Likely Gain-of-function 24218589 -ROS1 D2033N Likely Oncogenic Likely Gain-of-function 26673800 -ROS1 L1951R Inconclusive Inconclusive 25351743 -ROS1 C2060G Likely Oncogenic Likely Gain-of-function 24218589 -ROS1 SLC34A2-ROS1 Fusion Oncogenic Gain-of-function 22919003, 22215748, 22327623 -ROS1 TPM3-ROS1 Fusion Oncogenic Gain-of-function 22327623 -ROS1 TFG-ROS1 Fusion Likely Oncogenic Likely Gain-of-function 24875859 -ROS1 S1986Y Likely Oncogenic Likely Gain-of-function 27401242 -ROS1 G2032R Likely Oncogenic Likely Gain-of-function 25351743, 24047073, 24047072, 23724914, 27401242, 25688157 -ROS1 Fusions Likely Oncogenic Likely Gain-of-function 22919003, 23719267, 22215748 -ROS1 CD74-ROS1 Fusion Oncogenic Gain-of-function 22919003, 22215748, 18083107, 22327623 -ROS1 YWHAE-ROS1 Fusion Likely Oncogenic Likely Gain-of-function 24875859 -ROS1 LIMA1-ROS1 Fusion Likely Oncogenic Likely Gain-of-function 25264305 -ROS1 MSN-ROS1 Fusion Likely Oncogenic Likely Gain-of-function 25264305 -ROS1 EZR-ROS1 Fusion Oncogenic Gain-of-function 22327623 -ROS1 LRIG3-ROS1 Fusion Oncogenic Gain-of-function 22327623 -ROS1 Amplification Likely Oncogenic Likely Gain-of-function 25978031 -ROS1 V2098I Likely Oncogenic Likely Gain-of-function 24218589 -ROS1 SDC4-ROS1 Fusion Oncogenic Gain-of-function 22327623 -ROS1 L1947R Likely Oncogenic Likely Gain-of-function 24218589 -ROS1 CCDC6-ROS1 Fusion Likely Oncogenic Likely Gain-of-function 22975805, 25870798 -ASXL2 Truncating Mutations Likely Oncogenic Likely Loss-of-function 24973361 Li et al. Abstract# 1509, ASH 2016 http://www.bloodjournal.org/content/128/22/1509 -ASXL2 Deletion Likely Oncogenic Likely Loss-of-function 24973361 Li et al. Abstract# 1509, ASH 2016 http://www.bloodjournal.org/content/128/22/1509 -CDH1 D257N Likely Oncogenic Likely Loss-of-function 24690483 -CDH1 R732Q Likely Oncogenic Likely Loss-of-function 15235021, 17545690 -CDH1 T340A Oncogenic Loss-of-function 12588804 -CDH1 Deletion Likely Oncogenic Likely Loss-of-function 23812922, 2070412, 23341533, 19168852, 9515965, 24037103 -CDH1 Epigenetic Silencing Likely Oncogenic Likely Loss-of-function 11313896, 7543680 -CDH1 A617T Likely Oncogenic Loss-of-function 12588804 -CDH1 A634V Oncogenic Loss-of-function 12588804 -CDH1 D254N Oncogenic Loss-of-function 26123647 -CDH1 Truncating Mutations Likely Oncogenic Likely Loss-of-function 8934538, 2070412, 9515965, 17522512 -CDH1 A298T Likely Oncogenic Likely Loss-of-function 24204729 -EPCAM 3' Deletion Oncogenic Loss-of-function 21145788 -TOP1 Truncating Mutations Likely Oncogenic Likely Loss-of-function -EP300 EP300-MLL Fusion Likely Oncogenic Gain-of-function 18778367, 23307074, 9389684, 20980053 -EP300 Deletion Likely Oncogenic Likely Loss-of-function 10700188, 12402157, 12237408 -EP300 Fusions Likely Oncogenic Likely Gain-of-function 25943178, 26293203, 23307074 -EP300 Truncating Mutations Likely Oncogenic Likely Loss-of-function 10700188, 15156177, 12402157, 12237408 -EP300 D1399Y Likely Oncogenic Loss-of-function 12586840, 25151357 -EP300 P1502L Likely Oncogenic Loss-of-function 25151357 -EP300 C1385 Likely Oncogenic Loss-of-function 18273021 -EP300 EP300-MOZ Fusion Likely Oncogenic Gain-of-function 10824998, 23307074, 11243405 -EP300 Y1414C Likely Oncogenic Loss-of-function 25151357 -EP300 R1627 Likely Oncogenic Loss-of-function 18273021 -EPAS1 P531A Likely Oncogenic Likely Gain-of-function 23054256, 14691554, 12086860 -EPAS1 533_534del Likely Oncogenic Likely Gain-of-function 22931260, 23418310 -EPAS1 Y532C Likely Oncogenic Likely Gain-of-function 23361906, 23653463 -EPAS1 A530V Likely Oncogenic Likely Gain-of-function 22931260, 23418310 -EPAS1 A530T Likely Oncogenic Likely Gain-of-function 22931260, 23418310 -EPAS1 P531S Likely Oncogenic Likely Gain-of-function 22931260, 23418310 -EPAS1 P531L Likely Oncogenic Likely Gain-of-function 22931260, 23418310 -EPAS1 534_536del Likely Oncogenic Likely Gain-of-function 22931260, 23418310 -TP53 H179Q Likely Oncogenic Loss-of-function 22540896 -TP53 I255F Likely Oncogenic Likely Loss-of-function 25408419 -TP53 R158C Likely Oncogenic Likely Loss-of-function 17947339 -TP53 H179R Likely Oncogenic Loss-of-function 17361096, 22427690 -TP53 C238F Likely Oncogenic Loss-of-function 20407015 -TP53 G334R Likely Neutral Neutral 25584008 -TP53 R282W Likely Oncogenic Likely Loss-of-function 21445056 -TP53 H168N Likely Oncogenic Likely Loss-of-function 19462533 -TP53 S215G Oncogenic Loss-of-function 17724467, 8023157, 26619011, 22862161, 11900253 -TP53 G266R Likely Oncogenic Loss-of-function 16827139 -TP53 P219S Likely Oncogenic Loss-of-function 10229196, 25584008 -TP53 F338I Likely Oncogenic Likely Loss-of-function 19454241, 20978130 -TP53 R110L Likely Oncogenic Likely Loss-of-function 21445056, 16778209 -TP53 Truncating Mutations Likely Oncogenic Likely Loss-of-function 19336573, 27759562, 16007150, 11753428, 11900253, 21467160 -TP53 P153H Likely Oncogenic Likely Loss-of-function 15781620, 8023157, 11900253 -TP53 Y236C Likely Oncogenic Loss-of-function 16827139 -TP53 Q331H Likely Oncogenic Likely Loss-of-function 26619011, 20978130 -TP53 L330H Likely Oncogenic Likely Loss-of-function 19454241, 20978130 -TP53 L348F Likely Oncogenic Likely Loss-of-function 19454241 -TP53 V197E Likely Oncogenic Likely Loss-of-function 25408419 -TP53 R248L Likely Oncogenic Likely Loss-of-function 26748848, 25584008 -TP53 G244S Oncogenic Loss-of-function 26818906 -TP53 S121F Likely Oncogenic Likely Gain-of-function 15781620 -TP53 R283Q Likely Oncogenic Likely Loss-of-function 7651437 -TP53 C135S Likely Oncogenic Likely Loss-of-function 17914575, 8023157, 11900253 -TP53 K120E Oncogenic Loss-of-function 18524770, 24814347, 17189187 -TP53 R273G Likely Oncogenic Likely Loss-of-function 24677579, 26619011 -TP53 K120M Oncogenic Loss-of-function 17189187 -TP53 R248W Likely Oncogenic Loss-of-function 18762571, 10229196, 25584008 -TP53 H233N Likely Oncogenic Likely Loss-of-function 19462533, 26619011 -TP53 I251S Likely Oncogenic Likely Loss-of-function 26748848 -TP53 R290G Likely Oncogenic Likely Loss-of-function 15781620, 8023157, 26619011, 11900253 -TP53 R280K Oncogenic Loss-of-function 24714748 -TP53 R181H Likely Oncogenic Loss-of-function 20471942 -TP53 C277Q Likely Oncogenic Likely Loss-of-function 7651437 -TP53 H179L Oncogenic Loss-of-function 23150443 -TP53 G266E Likely Oncogenic Likely Loss-of-function 17724467 -TP53 G244R Oncogenic Loss-of-function 11160722 -TP53 Y234C Likely Oncogenic Loss-of-function 10229196, 26748848, 16861262 -TP53 T123A Likely Neutral Likely Neutral 16687402, 18996393 -TP53 K292T Likely Oncogenic Likely Loss-of-function 15781620, 8023157, 26619011, 11900253 -TP53 C176R Likely Oncogenic Loss-of-function 8633021 -TP53 S241F Likely Oncogenic Likely Loss-of-function 21383700 -TP53 F341C Likely Oncogenic Likely Loss-of-function 19454241, 20978130 -TP53 L145R Oncogenic Loss-of-function 8023157, 11900253 -TP53 R337L Likely Oncogenic Likely Loss-of-function 19454241, 20978130, 11481490 -TP53 R175C Likely Oncogenic Likely Loss-of-function 9632751, 26619011, 22955915 -TP53 C135R Likely Oncogenic Loss-of-function 17914575 -TP53 K120R Likely Oncogenic Loss-of-function 7651437, 17189187 -TP53 C238S Likely Oncogenic Loss-of-function 19681600 -TP53 I254T Oncogenic Loss-of-function 25584008 -TP53 S241T Likely Oncogenic Loss-of-function 11896595 -TP53 S121Y Inconclusive Inconclusive 15781620 -TP53 R175H Oncogenic Loss-of-function 15781620, 10713666, 21445056, 25584008, 22114072 -TP53 H179Y Likely Oncogenic Loss-of-function 17530187 -TP53 R248Q Likely Oncogenic Likely Loss-of-function 24814347, 21445056, 16778209 -TP53 R181L Likely Oncogenic Likely Loss-of-function 20471942 -TP53 H193N Likely Oncogenic Loss-of-function 19462533 -TP53 R213Q Likely Oncogenic Loss-of-function 10871862 -TP53 A347T Likely Oncogenic Likely Loss-of-function 19454241, 20978130 -TP53 R156C Likely Oncogenic Likely Loss-of-function 15781620, 8023157, 11900253 -TP53 P278A Likely Oncogenic Likely Loss-of-function 24076587 -TP53 N239S Oncogenic Loss-of-function 22553460 -TP53 V272M Likely Oncogenic Likely Loss-of-function 15037740, 11870884 -TP53 S121A Likely Neutral Likely Gain-of-function 15781620 -TP53 G356A Inconclusive Inconclusive 20978130 -TP53 H179N Likely Oncogenic Likely Loss-of-function 19462533 -TP53 P47S Likely Neutral Neutral 25584008 -TP53 R282Q Likely Oncogenic Likely Loss-of-function 18453682 -TP53 Y163C Likely Oncogenic Loss-of-function 8023157, 23246812, 15037740, 25584008, 11900253, 15077194 -TP53 S121C Inconclusive Inconclusive 15781620 -TP53 H214Q Likely Oncogenic Likely Loss-of-function 15781620, 26619011 -TP53 S240R Likely Oncogenic Likely Loss-of-function 10229196 -TP53 Y234H Likely Oncogenic Loss-of-function 22710932 -TP53 Y236S Likely Oncogenic Loss-of-function 11429705 -TP53 R337H Likely Oncogenic Likely Loss-of-function 19454241, 25584008, 11481490 -TP53 G245S Oncogenic Loss-of-function 2358418, 15037740 -TP53 P151H Likely Oncogenic Likely Loss-of-function 8023157, 22908277, 11900253 -TP53 R248K Likely Oncogenic Likely Loss-of-function 7651437 -TP53 K291E Likely Oncogenic Likely Loss-of-function 15781620, 8023157, 26619011, 11900253 -TP53 R273H Oncogenic Loss-of-function 26181206, 15037740, 25584008 -TP53 H214R Likely Oncogenic Likely Loss-of-function 20407015, 26619011 -TP53 Y236D Likely Oncogenic Loss-of-function 8633021 -TP53 Deletion Likely Oncogenic Likely Loss-of-function 26982726, 27759562, 19477430, 11900253, 12584563 -TP53 DNA binding domain deletions Oncogenic Loss-of-function 8023157, 11900253 -TP53 A161T Likely Oncogenic Likely Loss-of-function 21232794, 16827139 -TP53 P151S Oncogenic Loss-of-function 2857548 -TP53 S215C Likely Oncogenic Likely Loss-of-function 15781620, 26619011, 12917626 -TP53 H297N Likely Neutral Likely Neutral 19462533 -TP53 L344P Likely Oncogenic Loss-of-function 19454241, 20978130, 19106109 -TP53 Q331R Likely Oncogenic Likely Loss-of-function 20978130 -TP53 L330R Likely Oncogenic Likely Loss-of-function 19454241, 20978130 -TP53 R249S Likely Oncogenic Likely Loss-of-function 21445056, 18996393, 14741214 -TP53 K120A Likely Oncogenic Likely Loss-of-function 24814347, 16687402 -TP53 P316L Likely Oncogenic Likely Loss-of-function 10618702, 2553699, 20010306 -TP53 F212Y Inconclusive Inconclusive 15781620 -TP53 G199R Likely Oncogenic Likely Loss-of-function 10229196 -TP53 P250L Likely Oncogenic Likely Loss-of-function 21445056 -TP53 Y220C Oncogenic Loss-of-function 23315175, 15037740, 23630318 -TP53 DNA binding domain missense mutations Oncogenic Loss-of-function 8023157, 11900253 -TP53 G244D Likely Oncogenic Likely Loss-of-function 12901798 -TP53 C229R Likely Oncogenic Likely Loss-of-function 25584008 -TP53 C242Y Likely Oncogenic Loss-of-function 20407015 -TP53 V197L Likely Oncogenic Likely Loss-of-function 11668476 -TP53 R181C Likely Oncogenic Loss-of-function 10229196, 20471942 -TP53 G245D Likely Oncogenic Likely Loss-of-function 25119136, 22803791, 22214764 -TP53 R337C Likely Oncogenic Loss-of-function 19454241, 17311302, 16007150, 19106109, 11753428 -TP53 C242S Likely Oncogenic Loss-of-function 20407015 -TP53 C141Y Likely Oncogenic Likely Loss-of-function 15037740 -TP53 DNA binding domain insertions Oncogenic Loss-of-function 8023157, 11900253 -TP53 K292I Likely Oncogenic Likely Gain-of-function 15781620, 8023157, 11900253 -TP53 V173L Likely Oncogenic Loss-of-function 15037740 -TP53 Y220S Likely Oncogenic Loss-of-function 15977174 -TP53 H193R Likely Oncogenic Likely Loss-of-function 9627118 -TP53 R342P Likely Oncogenic Loss-of-function 19454241, 20978130 -TP53 C277W Likely Oncogenic Likely Loss-of-function 24814347 -TP53 F328V Likely Oncogenic Likely Loss-of-function 19454241 -TP53 V173E Likely Oncogenic Loss-of-function 9472631 -TP53 R156H Likely Oncogenic Loss-of-function 10435620 -TP53 R158H Likely Oncogenic Loss-of-function 10229196, 25584008 -TP53 R273L Likely Oncogenic Loss-of-function 8023157, 15037740, 11900253 -TP53 V274F Likely Oncogenic Likely Loss-of-function 12782597 -TP53 V157D Oncogenic Loss-of-function 23981578 -TP53 K291Q Likely Oncogenic Likely Loss-of-function 15781620, 8023157, 11900253 -TP53 S241Y Likely Oncogenic Loss-of-function 25584008 -TP53 E285K Likely Oncogenic Likely Loss-of-function 20407015 -TP53 P151A Likely Oncogenic Loss-of-function 20407015 -TP53 R280T Likely Oncogenic Likely Loss-of-function 22999923 -TP53 P278L Likely Oncogenic Loss-of-function 16861262 -TP53 E258V Likely Oncogenic Likely Loss-of-function 21445056 -TP53 E285V Oncogenic Loss-of-function 18762572, 25584008 -TP53 T329I Inconclusive Inconclusive 20978130 -TP53 L330P Likely Oncogenic Likely Loss-of-function 20978130 -TP53 M237K Likely Oncogenic Likely Loss-of-function 20505364 -TP53 R158L Likely Oncogenic Loss-of-function 15037740, 25584008, 16861262 -TP53 R290H Likely Oncogenic Likely Loss-of-function 10435620 -TP53 R273C Likely Oncogenic Likely Loss-of-function 15037740, 23863845, 11900253, 23612969 -TP53 E221Q Inconclusive Inconclusive 15781620 -TP53 H115N Inconclusive Inconclusive 19462533 -TP53 R249W Oncogenic Loss-of-function 23612969 -TP53 I162M Likely Oncogenic Likely Loss-of-function 15781620, 8023157, 11900253 -TP53 K120N Likely Oncogenic Loss-of-function 7651437 -TP53 V157F Likely Oncogenic Likely Loss-of-function 21561095, 15037740, 16778209 -TP53 R337P Likely Oncogenic Likely Loss-of-function 19454241, 20978130, 11481490 -TP53 Q144R Likely Oncogenic Likely Loss-of-function 15781620, 8023157, 26619011, 11900253 -TP53 H168R Likely Oncogenic Loss-of-function 18996393 -TP53 I195T Likely Oncogenic Likely Loss-of-function 8023157, 11900253, 12700230 -TP53 V143A Likely Oncogenic Likely Loss-of-function 10435620 -TP53 P278R Likely Oncogenic Loss-of-function 21760996 -TP53 C277R Likely Oncogenic Likely Loss-of-function 7651437 -TP53 R110P Likely Oncogenic Likely Loss-of-function 21445056 -TP53 P278S Likely Oncogenic Loss-of-function 22989750 -TP53 Q144P Likely Oncogenic Likely Loss-of-function 10229196 -TP53 E286K Likely Oncogenic Loss-of-function 15037740 -TP53 G245A Likely Oncogenic Likely Loss-of-function 20589832 -TP53 R249M Likely Oncogenic Loss-of-function 17999388, 15037740 -TP53 H193P Likely Oncogenic Loss-of-function 25584008 -TP53 M133T Likely Oncogenic Likely Loss-of-function 21311097 -TP53 R175L Likely Oncogenic Loss-of-function 15781620, 18762572, 25584008 -TP53 N235D Oncogenic Loss-of-function 25584008 -TP53 V272L Likely Oncogenic Likely Loss-of-function 20407015, 26619011 -TP53 R202S Likely Oncogenic Likely Loss-of-function 10229196 -TP53 T150I Likely Oncogenic Likely Loss-of-function 10229196 -TP53 R280A Likely Oncogenic Likely Loss-of-function 18524770, 24814347, 17189187 -TP53 A161S Likely Oncogenic Loss-of-function 25119136 -TP53 L344R Likely Oncogenic Likely Loss-of-function 19454241, 20978130 -TP53 D186A Likely Oncogenic Likely Loss-of-function 24814347 -TP53 E326L Likely Oncogenic Loss-of-function 26748848 -TP53 R267Q Likely Oncogenic Likely Loss-of-function 10435620, 25584008 -TP53 V218dup Oncogenic Loss-of-function 8023157, 11900253 -TP53 C275S Likely Oncogenic Loss-of-function 25584637 -TP53 L348S Likely Oncogenic Likely Loss-of-function 20978130 -TP53 C242F Likely Oncogenic Likely Loss-of-function 17401432 -TP53 C176F Likely Oncogenic Loss-of-function 22090360 -TP53 H214N Likely Oncogenic Likely Loss-of-function 19462533 -TP53 R267P Likely Oncogenic Likely Gain-of-function 23264849, 22989750 -TP53 C135Y Likely Oncogenic Switch-of-function 22847613 -TP53 G245C Likely Oncogenic Likely Loss-of-function 15037740, 22803791 -TP53 E180K Likely Oncogenic Loss-of-function 24814347, 20471942 -TP53 R273K Likely Oncogenic Loss-of-function 7651437 -TP53 F134Y Likely Oncogenic Likely Loss-of-function 26619011, 25584008 -TP53 P152L Likely Oncogenic Likely Loss-of-function 25584008 -TP53BP1 Truncating Mutations Likely Oncogenic Likely Loss-of-function 23103855 -TP53BP1 Deletion Likely Oncogenic Likely Loss-of-function 16260621, 22915756 -SMAD2 Deletion Likely Oncogenic Loss-of-function 15133179, 20010874, 16382155, 18618014, 12384562, 22204491, 19276350, 20852387 -SMAD2 F346V Likely Neutral Likely Neutral 11274206 -SMAD2 D450E Likely Oncogenic Likely Loss-of-function 23139211 -SMAD2 R310H Likely Oncogenic Likely Loss-of-function 11274206 -SMAD2 T413N Likely Oncogenic Likely Loss-of-function 23139211 -SMAD2 R428A Inconclusive Inconclusive 11779503 -SMAD2 N387P Inconclusive Inconclusive 11779503 -SMAD2 V319D Likely Oncogenic Likely Loss-of-function 11274206 -SMAD2 Y426A Likely Oncogenic Likely Loss-of-function 11779503, 9463378 -SMAD2 K375A Inconclusive Inconclusive 11779503 -SMAD2 S276L Likely Oncogenic Likely Loss-of-function 23139211 -SMAD2 S467P Likely Oncogenic Likely Loss-of-function 23139211 -SMAD2 K420A Likely Oncogenic Likely Loss-of-function 14729957, 11779503 -SMAD2 Y406H Inconclusive Inconclusive 11779503 -SMAD2 W368H Likely Neutral Likely Neutral 11274206, 11779503 -SMAD2 D300H Likely Oncogenic Likely Loss-of-function 11274206, 11779503 -SMAD2 D450H Likely Oncogenic Likely Loss-of-function 11779503 -SMAD2 R321Q Likely Oncogenic Loss-of-function 16828225, 20937913 -SMAD2 P305L Likely Oncogenic Likely Loss-of-function 23139211 -SMAD2 Truncating Mutations Likely Oncogenic Likely Loss-of-function 12894231, 23139211, 15711891, 11779503 -SMAD2 D300N Likely Oncogenic Likely Loss-of-function 23139211 -SMAD3 Truncating Mutations Likely Oncogenic Likely Loss-of-function 11691834 -SMAD3 Y297A Likely Oncogenic Likely Loss-of-function 21949838 -SMAD3 W406A Likely Oncogenic Likely Loss-of-function 21949838 -SMAD3 R292A Likely Oncogenic Likely Loss-of-function 21949838 -SMAD3 K341A Likely Oncogenic Likely Loss-of-function 21949838 -SMAD3 D258N Likely Oncogenic Loss-of-function 23139211 -SMAD3 D408H Likely Oncogenic Loss-of-function 21949838 -SMAD3 Y298A Likely Oncogenic Likely Loss-of-function 21949838 -SMAD3 R268A Likely Oncogenic Loss-of-function 21949838 -SMAD3 Y238A Likely Oncogenic Likely Loss-of-function 21949838 -SMAD3 D408Y Likely Oncogenic Loss-of-function 23139211 -SMAD3 P336S Likely Oncogenic Loss-of-function 23139211 -SMAD3 Deletion Likely Oncogenic Likely Loss-of-function 14647420, 18852474, 9753318, 16951153 -SMAD3 R373H Likely Oncogenic Likely Loss-of-function 16828225 -SMAD3 Y226A Likely Oncogenic Likely Loss-of-function 21949838 -SMAD3 Y237A Likely Neutral Neutral 17994767 -SMAD3 R373Q Likely Oncogenic Loss-of-function 23139211 -SMAD3 R287A Likely Oncogenic Loss-of-function 17994767 -SMAD3 D408E Likely Oncogenic Loss-of-function 10092624 -SMAD3 V356R Likely Oncogenic Likely Loss-of-function 21949838 -SMAD3 S425C Likely Oncogenic Loss-of-function 23139211 -SMAD3 Y384A Likely Oncogenic Likely Loss-of-function 21949838 -SMAD3 E239A Likely Oncogenic Loss-of-function 17994767 -SMAD3 V277D Likely Oncogenic Loss-of-function 10092624 -SMAD3 R243A Likely Oncogenic Likely Loss-of-function 21949838 -SMAD4 P130S Likely Oncogenic Loss-of-function 14647410 -SMAD4 E330A Likely Oncogenic Loss-of-function 17994767 -SMAD4 W398V Inconclusive Inconclusive 11274206 -SMAD4 L43V Likely Oncogenic Likely Loss-of-function 14647410 -SMAD4 C324Y Likely Oncogenic Likely Loss-of-function 22109972 -SMAD4 P102L Likely Oncogenic Likely Loss-of-function 14647410 -SMAD4 R441P Likely Neutral Likely Neutral 11274206, 11779503, 10822381 -SMAD4 Deletion Likely Oncogenic Loss-of-function 22321641, 25893305, 9482899, 10626800, 9506519, 17114584, 19841536, 10773876 -SMAD4 D493H Likely Oncogenic Loss-of-function 11274206, 19139564 -SMAD4 R378A Likely Oncogenic Likely Loss-of-function 15350224 -SMAD4 K507Q Likely Oncogenic Likely Loss-of-function 14647410 -SMAD4 Truncating Mutations Likely Oncogenic Likely Loss-of-function 23139211, 10340381, 15711891, 9094310, 11553622 -SMAD4 E330K Likely Oncogenic Loss-of-function 26488212 -SMAD4 R420H Likely Oncogenic Likely Neutral 11274206, 11779503 -SMAD4 R100T Likely Oncogenic Loss-of-function 14647410, 10092624 -SMAD4 R515A Likely Oncogenic Loss-of-function 11779503 -SMAD4 D357Y Likely Oncogenic Loss-of-function 14715079 -SMAD4 W509R Inconclusive Inconclusive 22316667 -SMAD4 K507A Likely Oncogenic Likely Loss-of-function 11779503 -SMAD4 R515G Likely Oncogenic Loss-of-function 14647410 -SMAD4 G419V Likely Oncogenic Loss-of-function 26488212 -SMAD4 D537E Likely Oncogenic Loss-of-function 9214508, 23139211, 14715079 -SMAD4 Y513A Inconclusive Inconclusive 11779503 -SMAD4 H132Y Likely Oncogenic Likely Loss-of-function 25275298 -SMAD4 E330G Likely Oncogenic Likely Loss-of-function 22316667 -SMAD4 R361C Likely Oncogenic Loss-of-function 9214508, 14647410, 26488212, 10092624 -SMAD4 K428A Likely Oncogenic Likely Loss-of-function 11779503 -SMAD4 D537Y Oncogenic Loss-of-function 23139211, 14715079 -SMAD4 V370D Likely Oncogenic Likely Loss-of-function 9214508, 11274206, 10092624, 19139564, 11779503 -SMAD4 R497H Likely Oncogenic Loss-of-function 14647410 -SMAD4 Y353L Likely Oncogenic Likely Loss-of-function 26619011 -SMAD4 D351H Likely Oncogenic Loss-of-function 9214508, 14647410, 11274206, 11779503, 14715079 -SMAD4 G508S Likely Oncogenic Likely Loss-of-function 9214508, 9153220 -SMAD4 D493A Likely Oncogenic Likely Loss-of-function 15350224 -SMAD4 R496H Likely Oncogenic Loss-of-function 26488212 -SMAD4 A532H Likely Oncogenic Loss-of-function 11274206 -SMAD4 V465M Inconclusive Inconclusive 22316667 -CDK4 R24C Oncogenic Gain-of-function 11606789, 11756559 -CDK4 Amplification Oncogenic Gain-of-function 20534551, 8101826, 10970848 -CDK4 K22A Oncogenic Gain-of-function 9426066, 9712735, 9228064 -AURKB Overexpression Likely Oncogenic Likely Gain-of-function 17344846, 26240282, 18347165, 16222316 -AURKB Amplification Likely Oncogenic Likely Gain-of-function 26240282 -CDK6 Amplification Oncogenic Gain-of-function 17989712, 23127611, 11940479, 20534551, 24736461, 22476749, 12900351, 19145199, 24764564 -CDK6 A197T Likely Neutral Loss-of-function 23918663 -FBXW7 G423R Likely Oncogenic Likely Loss-of-function 24838835, 26619011 -FBXW7 R505L Oncogenic Loss-of-function 17646409 -FBXW7 K11R Likely Oncogenic Likely Loss-of-function 20815813 -FBXW7 S462Y Likely Neutral Likely Neutral 27147599 -FBXW7 R465H Likely Oncogenic Loss-of-function 27147599, 24912918, 23228967, 17575125, 22608923 -FBXW7 D520N Likely Oncogenic Likely Loss-of-function 11565034, 19420964 -FBXW7 S562L Likely Neutral Neutral 24838835 -FBXW7 Truncating Mutations Likely Oncogenic Likely Loss-of-function 17646409, 15103331, 18094723 -FBXW7 R505C Oncogenic Loss-of-function 27147599, 17646408, 17575125, 23228967, 24838835, 22608923, 23095493 -FBXW7 S227A Likely Oncogenic Loss-of-function 21620836 -FBXW7 Deletion Likely Oncogenic Likely Loss-of-function 25314076, 27764699, 18367647, 15103331 -FBXW7 R479H Likely Oncogenic Loss-of-function 17575125 -FBXW7 R658Q Likely Oncogenic Likely Loss-of-function 27147599, 26619011 -FBXW7 I347M Likely Neutral Likely Neutral 27147599 -FBXW7 T205A Likely Neutral Likely Gain-of-function 22608923 -FBXW7 R465C Oncogenic Loss-of-function 17646408, 17909001, 17646409, 23095493 -FBXW7 R479Q Oncogenic Loss-of-function 17646408, 17909001, 23228967, 17646409 -FBXW7 R689Q Likely Oncogenic Likely Loss-of-function 27147599, 26619011 -FBXW7 R479L Likely Oncogenic Loss-of-function 24912918, 22608923 -FBXW7 R482Q Oncogenic Loss-of-function 23676439 -FBXW7 Copy Number Loss Oncogenic Loss-of-function 19739118, 24884509, 18367647, 18094723, 25555218, 22673505 -CDK8 Amplification Oncogenic Gain-of-function 18794900 -CDKN1A S31R Inconclusive Inconclusive 7655464, 20127253, 18046503, 17293864 -CDKN1A Truncating Mutations Likely Oncogenic Likely Loss-of-function 23159848, 24317508 -CDKN1A Deletion Likely Oncogenic Likely Loss-of-function 19106607, 25483104, 23624841, 15960923 -CDKN1B Deletion Oncogenic Loss-of-function 8646779, 23460367, 18073348, 21422114 -CDKN1B P133T Likely Oncogenic Likely Loss-of-function 21289244 -CDKN1B Truncating Mutations Likely Oncogenic Likely Loss-of-function 23555276, 8646779, 22129891, 21423803, 20492666, 25416039 -CDKN1B G9R Likely Oncogenic Loss-of-function 21289244 -CDKN1B V109G Inconclusive Inconclusive 22823061, 23652671 -CDKN2A D74N Oncogenic Loss-of-function 10491434, 19260062 -CDKN2A P81T Oncogenic Loss-of-function 20340136, 19260062, 10389768 -CDKN2A E69G Oncogenic Loss-of-function 20340136, 19260062 -CDKN2A D108H Likely Oncogenic Likely Loss-of-function 12606942 -CDKN2A D84V Oncogenic Loss-of-function 10491434 -CDKN2A R79P Oncogenic Loss-of-function 7647780 -CDKN2A R87W Oncogenic Loss-of-function 10491434, 19260062 -CDKN2A N71I Oncogenic Loss-of-function 20340136 -CDKN2A R112G Oncogenic Loss-of-function 20340136 -CDKN2A Deletion Oncogenic Loss-of-function 24071852, 9516223 -CDKN2A P81L Oncogenic Loss-of-function 20340136, 19260062, 10389768 -CDKN2A L32P Oncogenic Loss-of-function 20340136 -CDKN2A H83N Likely Oncogenic Loss-of-function 9660926 -CDKN2A N71S Oncogenic Loss-of-function 10491434 -CDKN2A L97R Oncogenic Loss-of-function 20340136, 19260062 -CDKN2A L16P Oncogenic Loss-of-function 20340136 -CDKN2A P114L Oncogenic Loss-of-function 19260062, 8755727 -CDKN2A G35A Likely Oncogenic Loss-of-function 20340136, 19260062 -CDKN2A D84H Likely Oncogenic Loss-of-function 8755727, 10498896 -CDKN2A A60R Oncogenic Loss-of-function 20340136, 19260062 -CDKN2A T77P Oncogenic Loss-of-function 19260062 -CDKN2A S56I Oncogenic Loss-of-function 20340136 -CDKN2A P73L Oncogenic Loss-of-function 7647780 -CDKN2A R99P Oncogenic Loss-of-function 20340136, 19260062 -CDKN2A G101W Oncogenic Loss-of-function 10491434, 20340136, 19260062, 8755727 -CDKN2A Q50P Oncogenic Loss-of-function 14508519 -CDKN2A G67S Oncogenic Loss-of-function 20340136, 19260062 -CDKN2A R80L Oncogenic Loss-of-function 10491434 -CDKN2A R80P Likely Oncogenic Likely Loss-of-function 10491434 -CDKN2A Q50* Oncogenic Loss-of-function 7987387 -CDKN2A R87P Oncogenic Loss-of-function 10491434, 19260062, 9607312 -CDKN2A D84Y Oncogenic Loss-of-function 10498896 -CDKN2A H83Y Oncogenic Loss-of-function 10491434, 9324288 -CDKN2A N71K Oncogenic Loss-of-function 20340136 -CDKN2A Truncating Mutations Likely Oncogenic Likely Loss-of-function 20340136, 9324288, 8603820 -CDKN2A A60V Likely Oncogenic Loss-of-function 20340136, 19260062 -CDKN2A D84N Likely Oncogenic Loss-of-function 8755727, 7777061, 10498896 -CDKN2A G35V Likely Oncogenic Loss-of-function 20340136, 19260062 -CDKN2A M53I Oncogenic Loss-of-function 20340136, 19260062 -CDKN2A A148T Inconclusive Inconclusive 15879498, 8603820, 7647780 -CDKN2A R87L Oncogenic Loss-of-function 10491434, 9607312 -CDKN2A A57V Oncogenic Loss-of-function 19260062 -CDKN2A D74Y Likely Oncogenic Loss-of-function 10491434, 19260062 -CDKN2A D108N Likely Oncogenic Likely Loss-of-function 12417717 -CDKN2A A36P Oncogenic Loss-of-function 20340136 -CDKN2A V118D Oncogenic Loss-of-function 7647780 -CDKN2A G93W Likely Oncogenic Loss-of-function 7647780 -CDKN2A I49S Oncogenic Loss-of-function 20340136 -CDKN2A D84G Oncogenic Loss-of-function 10491434 -CDKN2A E88K Oncogenic Loss-of-function 10498896 -CDKN2A A68T Oncogenic Loss-of-function 20340136 -CDKN2A V126D Oncogenic Loss-of-function 20340136 -CDKN2A G35R Likely Oncogenic Loss-of-function 20340136, 19260062 -CDKN2A G67R Oncogenic Loss-of-function 20340136, 19260062 -CDKN2A G23D Oncogenic Loss-of-function 20340136, 19260062 -CDKN2A P114S Oncogenic Loss-of-function 19260062, 8755727 -CDKN2A P48L Oncogenic Loss-of-function 10491434 -CDKN2A R24P Oncogenic Loss-of-function 20340136 -CDKN2B Truncating Mutations Likely Oncogenic Likely Loss-of-function 12032783, 9479825, 11485924 -CDKN2B E35* Oncogenic Loss-of-function 25873077 -CDKN2B D86N Oncogenic Loss-of-function 23715670, 25873077 -CDKN2B Hypermethylation Oncogenic Loss-of-function 19064397, 17489980 -CDKN2B P40T Oncogenic Loss-of-function 25873077 -CDKN2B A23E Oncogenic Loss-of-function 25873077 -CDKN2B Deletion Oncogenic Loss-of-function 12032783, 8078588, 9479825 -CDKN2C Deletion Likely Oncogenic Likely Loss-of-function 18829482, 21994415 -CDKN2C Truncating Mutations Likely Oncogenic Likely Loss-of-function -ASXL1 Deletion Likely Oncogenic Likely Loss-of-function 24255920, 22897849, 24218140 -ASXL1 Truncating Mutations Likely Oncogenic Likely Loss-of-function 19388938, 24216483, 22897849, 21455215, 26095772 -ERBB2 G309A Oncogenic Gain-of-function 23220880, 22908275 -ERBB2 Y1248F Likely Neutral Loss-of-function 1671296 -ERBB2 D808N Likely Oncogenic Likely Gain-of-function 25435280 -ERBB2 Y803N Inconclusive Inconclusive 18413839 -ERBB2 G776S Likely Oncogenic Gain-of-function 18039657 -ERBB2 G292R Likely Oncogenic Likely Gain-of-function 24997986 -ERBB2 Y772_A775dup Oncogenic Gain-of-function 23220880, 16843263, 22908275 -ERBB2 D769A Likely Neutral Loss-of-function 23843458 -ERBB2 T216S Likely Neutral Likely Neutral 22908275, 18772396, 18772890 -ERBB2 G660D Likely Oncogenic Gain-of-function 24317180, 26545934 -ERBB2 N857S Likely Oncogenic Likely Gain-of-function 22046346 -ERBB2 T798M Likely Oncogenic Likely Gain-of-function 22046346 -ERBB2 R896C Oncogenic Gain-of-function 23220880 -ERBB2 Amplification Oncogenic Gain-of-function 23204226, 12124352, 2885917, 24656976, 10716706, 11571643 -ERBB2 C311R Oncogenic Gain-of-function 22908275, 18772890 -ERBB2 G778_P780dup Oncogenic Gain-of-function 23220880 -ERBB2 R143Q Likely Neutral Likely Neutral 24971884 -ERBB2 N319D Likely Neutral Likely Neutral 22908275, 18772396, 18772890, 23389443 -ERBB2 E321G Oncogenic Gain-of-function 22908275, 18772890 -ERBB2 S310Y Oncogenic Gain-of-function 24516025, 24997986, 22908275, 26358791 -ERBB2 M774_A775insAYVM Oncogenic Gain-of-function 17311002 -ERBB2 L726I Likely Oncogenic Gain-of-function 17638894 -ERBB2 Exon 20 insertions/deletions Oncogenic Gain-of-function 16775247, 23220880, 16843263, 23610105, 21353324, 22649146, 22325357, 25899785 -ERBB2 L785F Inconclusive Inconclusive 18413839 -ERBB2 C630Y Inconclusive Inconclusive 18413839 -ERBB2 L726F Likely Oncogenic Likely Gain-of-function 18413839, 25435280 -ERBB2 L869R Likely Oncogenic Likely Gain-of-function 21531810, 26305917, 16397024 Hyman et al. Abstract# PD5-05, AACR 2016 http://cancerres.aacrjournals.org/content/76/4_Supplement/PD5-05 -ERBB2 L755S Oncogenic Gain-of-function 22046346, 18413839, 23220880 -ERBB2 V842I Oncogenic Gain-of-function 24997986, 23220880 -ERBB2 E265K Likely Oncogenic Likely Gain-of-function 24997986 -ERBB2 L915M Inconclusive Inconclusive 18413839 -ERBB2 S653C Oncogenic Gain-of-function 24971884 -ERBB2 D769H Oncogenic Gain-of-function 23220880, 23843458 -ERBB2 V773A Likely Oncogenic Likely Gain-of-function 22046346, 26619011, 16299242 -ERBB2 D769Y Oncogenic Gain-of-function 23220880 -ERBB2 D821N Likely Oncogenic Likely Gain-of-function 18413839 -ERBB2 G309E Oncogenic Gain-of-function 22908275 -ERBB2 V794M Likely Oncogenic Likely Gain-of-function 25435280 -ERBB2 S760A Likely Neutral Likely Neutral 23220880 -ERBB2 E719K Inconclusive Inconclusive 18413839 -ERBB2 L755_T759del Oncogenic Gain-of-function 23220880, 15118073, 15329413, 15118125 -ERBB2 E717K Inconclusive Inconclusive 18413839 -ERBB2 G776delinsLC Oncogenic Gain-of-function 26545934 -ERBB2 C334S Oncogenic Gain-of-function 22908275, 18772890 -ERBB2 Exon 20 insertions Oncogenic Gain-of-function 16775247, 23220880, 16843263, 23610105, 21353324, 22649146, 22325357, 25899785 -ERBB2 K753A Likely Neutral Loss-of-function 22393464, 23680147 -ERBB2 V750E Likely Neutral Likely Neutral 22908275, 18772396, 18772890, 23389443 -ERBB2 L49H Likely Neutral Likely Neutral 22908275, 18772396, 18772890, 23389443 -ERBB2 S783P Inconclusive Inconclusive 18413839 -ERBB2 H878Y Likely Oncogenic Gain-of-function 22046346, 25853726 -ERBB2 D277H Likely Oncogenic Likely Gain-of-function 24971884 -ERBB2 K753E Inconclusive Inconclusive 27697991 -ERBB2 S310F Oncogenic Gain-of-function 24516025, 24997986, 22908275, 26358791 -ERBB2 S335C Likely Oncogenic Likely Gain-of-function 23630663 -ERBB2 V777M Likely Neutral Likely Neutral 18039657, 25720673 -ERBB2 A775_G776insYVMA Oncogenic Gain-of-function 17311002 -ERBB2 V777L Oncogenic Gain-of-function 24516025, 22046346, 23220880 -ERBB2 V777A Likely Oncogenic Likely Gain-of-function 26619011, 22908275, 18772396, 18772890, 23389443 -ERBB2 Y835F Likely Neutral Likely Loss-of-function 23220880 -ERBB2 I767M Oncogenic Gain-of-function 25994018, 23220880 -ERBB2 D845A Likely Neutral Loss-of-function 22908275 -ERBB2 P780L Likely Oncogenic Likely Gain-of-function 18413839 -ERBB2 S1002R Inconclusive Inconclusive 18413839 -ERBB2 L866M Oncogenic Gain-of-function 26243863 -ERBB2 T862A Oncogenic Gain-of-function 22046346 -ERBB2 T733I Likely Oncogenic Likely Gain-of-function 18413839, 16397024 -ERBB2 E719G Inconclusive Inconclusive 18413839 -ERBB2 E812K Inconclusive Inconclusive 18413839 -ERBB2 K753M Likely Neutral Loss-of-function 16489002 -ERBB2 T798I Likely Oncogenic Likely Switch-of-function 18413839, 28274957 -ERBB2 R678Q Likely Oncogenic Likely Gain-of-function 24971884, 23220880 -ERBB2 V839G Inconclusive Inconclusive 18413839 -ERBB2 L755P Oncogenic Gain-of-function 22046346 -ERBB2 G776_V777insYVMA Oncogenic Gain-of-function 16843263 -ERBB2 V659E Oncogenic Gain-of-function 1671296, 7821711 -ERBB2 G776delinsVC Oncogenic Gain-of-function 26545934 -ERBB3 V104M Oncogenic Gain-of-function 23680147 -ERBB3 P262H Oncogenic Gain-of-function 23680147 -ERBB3 A232V Oncogenic Gain-of-function 23680147 -ERBB3 T389K Oncogenic Gain-of-function 23680147 -ERBB3 S846I Oncogenic Gain-of-function 23680147 -ERBB3 Q809R Oncogenic Gain-of-function 23680147 -ERBB3 R669C Inconclusive Inconclusive 23741632 -ERBB3 Amplification Oncogenic Gain-of-function 20418034, 24886126, 25739551 -ERBB3 G284R Oncogenic Gain-of-function 23680147 -ERBB3 V104L Oncogenic Gain-of-function 23680147 -ERBB3 E928G Oncogenic Gain-of-function 23680147 -ERBB3 V714M Likely Neutral Likely Neutral 23680147 -ERBB3 A1131T Inconclusive Inconclusive 23741632 -ERBB4 E542K Oncogenic Gain-of-function 19718025 -ERBB4 G936R Inconclusive Inconclusive 21701703 -ERBB4 K935I Oncogenic Gain-of-function 26050618 -ERBB4 E872K Oncogenic Gain-of-function 19718025 -ERBB4 H618P Likely Neutral Neutral 26050618 -ERBB4 EZR-ERBB4 Fusion Oncogenic Gain-of-function 24727320, 22327623 -ERBB4 M887I Inconclusive Inconclusive 25435280 -ERBB4 T244R Likely Neutral Neutral 26050618 -ERBB4 D595V Oncogenic Gain-of-function 26050618 -ERBB4 E452K Oncogenic Gain-of-function 19718025 -ERBB4 D931Y Likely Oncogenic Gain-of-function 26050618 -ERBB4 Fusions Likely Oncogenic Likely Gain-of-function 24727320 -ERBB4 G785S Inconclusive Inconclusive 25435280 -ERBB4 N181S Likely Neutral Neutral 26050618 -ERBB4 V348L Likely Neutral Neutral 26050618 -ERBB4 R544W Oncogenic Gain-of-function 19718025 -ERBB4 R306S Likely Oncogenic Gain-of-function 26050618 -ERBB4 E317K Oncogenic Gain-of-function 19718025 -ERBB4 E836K Oncogenic Gain-of-function 19718025 -ERBB4 Y285C Oncogenic Gain-of-function 26050618 -ERBB4 E563K Oncogenic Gain-of-function 19718025 -ERBB4 R838Q Inconclusive Inconclusive 25435280 -ERCC2 D513Y Likely Oncogenic Likely Loss-of-function 27504877 -ERCC2 D423N Likely Oncogenic Likely Loss-of-function 27504877 -ERCC2 R631C Likely Oncogenic Likely Loss-of-function 27504877 -ERCC2 N238S Likely Oncogenic Likely Loss-of-function 25096233 -ERCC2 R487W Likely Oncogenic Likely Loss-of-function 27504877 -ERCC2 L461V Likely Oncogenic Likely Loss-of-function 27504877 -ERCC2 D609E Likely Oncogenic Likely Loss-of-function 25096233 -ERCC2 F568fs Likely Oncogenic Likely Loss-of-function 27504877 -ERCC2 G665A Likely Oncogenic Likely Loss-of-function 25096233 -ERCC2 A717G Likely Oncogenic Likely Loss-of-function 27504877 -ERCC2 R592H Likely Neutral Likely Neutral 27504877 -ERCC2 P463L Likely Oncogenic Likely Loss-of-function 25096233 -ERCC2 R450H Likely Neutral Likely Neutral 27504877 -ERCC2 V242F Likely Oncogenic Likely Loss-of-function 25096233 -ERCC2 Y24C Likely Oncogenic Likely Loss-of-function 25096233 -ERCC2 D609G Likely Oncogenic Likely Loss-of-function 25096233 -ERCC2 Amplification Likely Oncogenic Likely Gain-of-function 25096233 -ERCC2 S746fs Likely Oncogenic Likely Loss-of-function 27504877 -ERCC2 Truncating Mutations Likely Oncogenic Likely Loss-of-function -ERCC2 E606G Likely Oncogenic Likely Loss-of-function 25096233 -ERCC2 R601Q Likely Oncogenic Likely Loss-of-function 27504877 -ERCC2 V536M Likely Oncogenic Likely Loss-of-function 27504877 -BRIP1 Truncating Mutations Likely Oncogenic Likely Loss-of-function 16153896, 24040146, 17033622, 21964575, 18628483 -BRIP1 M299I Inconclusive Inconclusive 17145708, 11301010, 14983014 -BRIP1 R173C Oncogenic Loss-of-function 12569564 -BRIP1 R798* Likely Oncogenic Likely Loss-of-function 16153896, 17033622 -BRIP1 K52R Oncogenic Loss-of-function 11301010, 2846277, 8196650, 14983014 -BRIP1 A349P Likely Oncogenic Likely Loss-of-function 20639400, 16116424 -BRIP1 P47A Oncogenic Loss-of-function 11301010, 14983014 -BRIP1 Deletion Likely Oncogenic Likely Loss-of-function 24040146, 21964575, 18628483 -ERCC3 R109* Likely Oncogenic Loss-of-function 27655433 -ERCC3 Truncating Mutations Likely Oncogenic Likely Loss-of-function 16143348, 19942596, 27655433, 8196650 -ERCC4 S786F Oncogenic Loss-of-function 24027083 -ERCC4 Deletion Likely Oncogenic Likely Loss-of-function 9580660, 26074087, 23623386 -ERCC4 E875G Oncogenic Loss-of-function 10499592 -ERCC4 L230P Oncogenic Loss-of-function 23623386 -ERCC4 Truncating Mutations Likely Oncogenic Likely Loss-of-function 9580660, 8887684 -ERCC4 R689S Oncogenic Loss-of-function 24027083, 23623386 -ABL1 M351T Likely Oncogenic Likely Gain-of-function 16046538, 21562040 -ABL1 Y253H Likely Oncogenic Likely Gain-of-function 16482207 -ABL1 E355A Likely Oncogenic Likely Gain-of-function 24456693 -ABL1 Fusions Likely Oncogenic Likely Gain-of-function 21435002 -ABL1 Y253F Oncogenic Gain-of-function 16880519 -ABL1 E459K Likely Oncogenic Likely Gain-of-function 19201023 -ABL1 V299L Likely Oncogenic Likely Gain-of-function 23086624, 18242697 -ABL1 F311L Likely Oncogenic Likely Gain-of-function 21562040 -ABL1 H396P Likely Oncogenic Likely Gain-of-function 21562040, 16424036 -ABL1 L248V Likely Oncogenic Likely Gain-of-function 21562040 -ABL1 F359C Likely Oncogenic Likely Gain-of-function 19798095 -ABL1 L384M Likely Oncogenic Likely Gain-of-function 21562040 -ABL1 L387M Likely Oncogenic Likely Gain-of-function 21562040 -ABL1 D276G Oncogenic Gain-of-function 15510211 -ABL1 E255V Likely Oncogenic Likely Gain-of-function 21562040 -ABL1 F317L Likely Oncogenic Likely Gain-of-function 21562040 -ABL1 E355G Likely Oncogenic Likely Gain-of-function 21562040 -ABL1 F359V Likely Oncogenic Likely Gain-of-function 21562040 -ABL1 T315I Likely Oncogenic Likely Gain-of-function 18794843, 11423618 -ABL1 V379I Likely Oncogenic Likely Gain-of-function 21562040 -ABL1 E279K Likely Oncogenic Likely Gain-of-function 21562040 -ABL1 Q252H Likely Oncogenic Likely Gain-of-function 16046538, 21562040 -ABL1 V289F Likely Oncogenic Likely Gain-of-function 23355941 -ABL1 G250E Likely Oncogenic Likely Gain-of-function 21562040 -ABL1 BCR-ABL1 Fusion Oncogenic Gain-of-function 11345193, 18851712 -ABL1 E281K Likely Oncogenic Likely Gain-of-function 21193419 -ABL1 E255K Likely Oncogenic Likely Gain-of-function 15194504 -ABL1 H396R Likely Oncogenic Likely Gain-of-function 21562040 -ABL1 M244V Likely Oncogenic Likely Gain-of-function 21562040 -CEBPA Truncating Mutations Likely Oncogenic Likely Loss-of-function 11830484, 19322763, 19651529, 18768433, 19075268 -ERF Truncating Mutations Likely Oncogenic Likely Loss-of-function 21548782, 17699159, 17525531, 22198386 -ERG Fusions Likely Oncogenic Likely Gain-of-function 19649210, 23625457, 20585344 -ERG TMPRSS2-ERG Fusion Oncogenic Gain-of-function 22142399, 19396167, 18283340, 17043636 -ERG FUS-ERG Fusion Oncogenic Gain-of-function 8187069, 7970732, 9653171, 25453903 -ERG EWSR1-ERG Fusion Oncogenic Gain-of-function 16357154, 8162068, 25453903 -HLA-A Truncating Mutations Likely Oncogenic Likely Loss-of-function 15546342 -HLA-A 596_619splice Likely Oncogenic Likely Loss-of-function 16216676 -HLA-B Truncating Mutations Likely Oncogenic Likely Loss-of-function 26889905, 19845903, 27807939, 14675390, 28205408 -PDGFRA D1071N Likely Neutral Neutral 23752188 -PDGFRA H845Y Likely Oncogenic Gain-of-function 24132921 -PDGFRA Fusions Likely Oncogenic Likely Gain-of-function 20889717 -PDGFRA V658A Likely Oncogenic Gain-of-function 24132921 -PDGFRA N659K Likely Oncogenic Gain-of-function 15928335 -PDGFRA C456_N468del Oncogenic Gain-of-function 23970477 -PDGFRA C456_R481del Oncogenic Gain-of-function 23970477 -PDGFRA V561_I562insER Oncogenic Gain-of-function 15928335, 12522257 -PDGFRA N870S Likely Neutral Neutral 23752188 -PDGFRA H570R Likely Neutral Neutral 21224473 -PDGFRA BCR-PDGFRA Fusion Likely Oncogenic Gain-of-function 12023981, 12944919, 15034867 -PDGFRA I843del Likely Oncogenic Gain-of-function 22745105 -PDGFRA I834V Likely Neutral Neutral 24132921 -PDGFRA KDR-PDGFRA Fusion Oncogenic Gain-of-function 20889717, 16690743 -PDGFRA FIP1L1-PDGFRA Fusion Oncogenic Gain-of-function 16754777, 19187542, 16645167, 24057647, 12660384, 16690743, 24407160, 16608506, 21224473, 19212337, 12781364, 27021554, 16030188 -PDGFRA W349C Likely Neutral Likely Loss-of-function 23752188 -PDGFRA T674I Likely Oncogenic Likely Gain-of-function 22745105 -PDGFRA E996K Likely Neutral Neutral 23752188 -PDGFRA P577S Likely Oncogenic Gain-of-function 24132921 -PDGFRA Y555C Likely Oncogenic Gain-of-function 25975287, 17087943 -PDGFRA CDK5RAP2-PDGFRA Fusion Oncogenic Gain-of-function 16845659 -PDGFRA V544_L545insAVLVLLVIVIISLI Oncogenic Gain-of-function 23970477 -PDGFRA A633T Likely Oncogenic Likely Gain-of-function 24132921 -PDGFRA E311_K312del Oncogenic Gain-of-function 23970477 -PDGFRA P130S Likely Neutral Likely Neutral 23752188 -PDGFRA I562M Likely Neutral Neutral 21224473 -PDGFRA H845_N848delinsP Oncogenic Gain-of-function 15928335, 12522257, 22745105 -PDGFRA H650Q Oncogenic Gain-of-function 21224473 -PDGFRA S478P Likely Neutral Likely Neutral 22733151, 12949711, 19366796 -PDGFRA N659R Likely Oncogenic Gain-of-function 15928335 -PDGFRA V561D Oncogenic Gain-of-function 17087936, 12949711, 15928335, 19217431, 12522257, 18955458, 22665524, 22745105 -PDGFRA C450_K451insMIEWMI Oncogenic Gain-of-function 23970477 -PDGFRA V561A Oncogenic Likely Gain-of-function 24132921 -PDGFRA N659S Likely Oncogenic Gain-of-function 21224473 -PDGFRA ETV6-PDGFRA Fusion Oncogenic Gain-of-function 17555450 -PDGFRA KIF5B-PDGFRA Fusion Oncogenic Gain-of-function 17555450, 16498388 -PDGFRA Q579R Likely Oncogenic Gain-of-function 24132921 -PDGFRA D842_H845del Likely Oncogenic Gain-of-function 22745105 -PDGFRA V536E Oncogenic Gain-of-function 23752188 -PDGFRA D842Y Likely Oncogenic Gain-of-function 15928335, 24132921, 22745105 -PDGFRA F808L Likely Neutral Loss-of-function 23752188 -PDGFRA D842_I843delinsIM Oncogenic Gain-of-function 15928335, 22745105 -PDGFRA S566_E571delinsR Likely Oncogenic Gain-of-function 15928335, 12522257 -PDGFRA A633V Likely Neutral Neutral 24132921 -PDGFRA R481G Likely Neutral Likely Neutral 21224473 -PDGFRA 560_561insER Oncogenic Gain-of-function 22745105 -PDGFRA D842I Likely Oncogenic Gain-of-function 15928335, 22745105 -PDGFRA Y375_K455del Oncogenic Gain-of-function 20889717, 12569364 -PDGFRA Y849S Likely Oncogenic Gain-of-function 21224473 -PDGFRA G829R Likely Neutral Neutral 23752188 -PDGFRA Y849C Likely Oncogenic Gain-of-function 15146165, 15928335 -PDGFRA R841K Oncogenic Gain-of-function 24132921 -PDGFRA L507P Likely Neutral Likely Neutral 24057647, 21224473 -PDGFRA D846Y Likely Oncogenic Gain-of-function 15928335, 22745105 -PDGFRA Amplification Oncogenic Gain-of-function 21931021, 20685895, 18772890, 22745105, 16357008 -PDGFRA W559_R560del Oncogenic Gain-of-function 26396737 -PDGFRA S584L Likely Oncogenic Gain-of-function 24132921 -PDGFRA D842V Oncogenic Gain-of-function 24132921, 22665524, 23752188, 18794084, 17087936, 12949711, 15928335, 23970477, 19217431, 12522257, 18955458, 22745105, 15685537, 16030188 -PDGFRA D568N Likely Oncogenic Gain-of-function 24132921 -PDGFRA K830R Likely Neutral Neutral 24132921 -PDGFRA N848K Likely Oncogenic Gain-of-function 15928335 -PDGFRA I843_D846del Likely Oncogenic Gain-of-function 18955458, 22745105 -PDGFRA R748G Oncogenic Gain-of-function 21224473 -PDGFRA STRN-PDGFRA Fusion Oncogenic Gain-of-function 17555450 -PDGFRA G853D Oncogenic Gain-of-function 24132921 -PDGFRA D842_M844del Likely Oncogenic Gain-of-function 18794084 -PDGFRA V469A Likely Oncogenic Likely Gain-of-function 23752188 -PDGFRB GIT2-PDGFRB Fusion Likely Oncogenic Likely Gain-of-function 17296564, 18262053 -PDGFRB KIAA1509-PDGFRB Fusion Likely Oncogenic Likely Gain-of-function 12907457 -PDGFRB SPTBN1-PDGFRB Fusion Likely Oncogenic Likely Gain-of-function 18262053 -PDGFRB NIN-PDGFRB Fusion Likely Oncogenic Likely Gain-of-function 15087377 -PDGFRB R561C Inconclusive Inconclusive 23731537 -PDGFRB HIP1-PDGFRB Fusion Oncogenic Gain-of-function 9616134 -PDGFRB RABEP1-PDGFRB Fusion Oncogenic Gain-of-function 11588050 -PDGFRB Amplification Inconclusive Inconclusive 18515258, 18157090, 18612157, 16630177, 21729646, 18670317 -PDGFRB ATF7IP-PDGFRB Fusion Likely Oncogenic Likely Gain-of-function 8168137 -PDGFRB TP53BP1-PDGFRB Fusion Likely Oncogenic Likely Gain-of-function 15492236 -PDGFRB PRKG2-PDGFRB Fusion Likely Oncogenic Likely Gain-of-function 17296564, 18262053 -PDGFRB L658P Likely Neutral Loss-of-function 23255827, 26599395 -PDGFRB E1071W Likely Neutral Likely Loss-of-function 23255827, 26599395 -PDGFRB P660T Inconclusive Inconclusive 23731542 -PDGFRB PDE4DIP-PDGFRB Fusion Likely Oncogenic Likely Gain-of-function 12907457 -PDGFRB ETV6-PDGFRB Fusion Oncogenic Gain-of-function 22271894, 8168137, 19644140, 19100521 -PDGFRB KANK1-PDGFRB Fusion Oncogenic Gain-of-function 21685469 -PDGFRB GOLGA4-PDGFRB Fusion Likely Oncogenic Likely Gain-of-function 20085582 -PDGFRB R987W Likely Neutral Likely Loss-of-function 23255827, 26599395 -PDGFRB WDR48-PDGFRB Fusion Likely Oncogenic Likely Gain-of-function 20085582 -PDGFRB Fusions Likely Oncogenic Likely Gain-of-function 20581310, 8962143, 19806146, 22271894, 8168137, 22897847, 18483217 -PDGFRB EBF1-PDGFRB Fusion Oncogenic Gain-of-function 24186319, 8168137, 22897847, 23835704 -PDGFRB GPIAP1-PDGFRB Fusion Likely Oncogenic Likely Gain-of-function 17296564 -PDGFRB V665A Oncogenic Loss-of-function 26279204 -PDGFRB BIN2-PDGFRB Fusion Likely Oncogenic Likely Gain-of-function 20085582 -PDGFRB CEP85L-PDGFRB Fusion Oncogenic Likely Gain-of-function 23186533, 15492236 -RBM10 Deletion Likely Oncogenic Likely Loss-of-function 26853560, 24000153, 24332178 -RBM10 V354E Oncogenic Loss-of-function 20007775, 24332178 -RBM10 Truncating Mutations Likely Oncogenic Likely Loss-of-function 21910224, 24000153, 22980975, 25079552, 24332178 -KDM5C M1_E165DEL Likely Oncogenic Loss-of-function 25666439 -KDM5C P480L Likely Oncogenic Loss-of-function 25666439 -KDM5C D402Y Likely Oncogenic Loss-of-function 25666439 -KDM5C Overexpression Likely Oncogenic Likely Gain-of-function 25016185 -KDM5C Truncating Mutations Likely Oncogenic Likely Loss-of-function -KDM5C V1075Yfs*2 Likely Oncogenic Loss-of-function 25666439 -ESR1 V534E Likely Neutral Neutral 27986707 -ESR1 Y537N Likely Oncogenic Gain-of-function 24185512, 24398047, 24185510, 9102207, 11322512, 9500442 -ESR1 L536P Likely Oncogenic Gain-of-function 10787412, 9234721, 1630819, 9774463, 15282324 -ESR1 A546D Oncogenic Gain-of-function 27986707 -ESR1 Y537S Oncogenic Gain-of-function 24185512, 24185510, 26836308, 27986707, 8923465, 9398213, 11914066 -ESR1 ESR1-CCDC170 Fusion Oncogenic Gain-of-function 25099679, 22496636, 22101766 -ESR1 V422del Likely Oncogenic Gain-of-function 27986707 -ESR1 ESR1-YAP1 Fusion Oncogenic Gain-of-function 24055055 -ESR1 S432L Likely Neutral Neutral 27986707 -ESR1 D538G Oncogenic Gain-of-function 24185512, 24398047, 24185510, 24217577, 1630819, 26836308, 15282324 -ESR1 L536R Likely Oncogenic Gain-of-function 24185512, 1630819, 15282324 -ESR1 E380Q Likely Oncogenic Gain-of-function 9259327, 1630819, 8114756, 15282324 -ESR1 S463P Likely Oncogenic Likely Gain-of-function 24185512, 1630819, 15282324 -ESR1 L536Q Likely Oncogenic Gain-of-function 24185510, 1630819, 15282324 -ESR1 L536H Likely Oncogenic Gain-of-function 1630819, 15282324, 15159406 -ESR1 Y537C Likely Oncogenic Gain-of-function 24398047, 24185510, 1630819, 11322512, 9500442, 15282324 -ESR1 L469V Likely Oncogenic Gain-of-function 1630819, 27986707, 15282324 -ESR1 Fusions Likely Oncogenic Likely Gain-of-function 25099679, 24055055 -ETV1 EWSR1-ETV1 Fusion Oncogenic Gain-of-function 16357154, 7700648, 25453903 -ETV1 Amplification Oncogenic Gain-of-function 23908683, 20160028 -ETV1 Fusions Likely Oncogenic Likely Gain-of-function 23814484, 21298110, 18794142, 23625457, 17671502 -ETV1 TMPRSS2-ETV1 Fusion Oncogenic Gain-of-function 18563191, 23512661 -ETV6 R369W Likely Oncogenic Likely Loss-of-function 25581430, 26522332, 27365488 -ETV6 R418G Likely Oncogenic Loss-of-function 25807284 -ETV6 ETV6-NTRK3 Fusion Oncogenic Gain-of-function 21804605, 18068631, 21148487 -ETV6 385_418del Likely Oncogenic Loss-of-function 25807284 -ETV6 R369Q Likely Oncogenic Likely Loss-of-function 25581430, 26522332, 26102509, 27365488 -ETV6 ETV6-FLT3 Fusion Oncogenic Gain-of-function 16761019 -ETV6 P214L Likely Oncogenic Loss-of-function 25807284 -ETV6 Fusions Likely Oncogenic Likely Gain-of-function 12173038, 10702799, 22578774 -TSC1 Truncating Mutations Likely Oncogenic Likely Loss-of-function 23485365, 24529379, 20301399 -TSC1 F216A Likely Oncogenic Likely Loss-of-function 18397877 -TSC1 H68R Likely Oncogenic Likely Loss-of-function 18397877 -TSC1 L180P Likely Oncogenic Loss-of-function 18830229 -TSC1 R1097H Likely Neutral Neutral 18830229 -TSC1 V128del Likely Oncogenic Loss-of-function 18830229 -TSC1 L191H Likely Oncogenic Loss-of-function 18830229 -TSC1 G305W Likely Neutral Neutral 18830229 -TSC1 M224R Oncogenic Loss-of-function 18830229 -TSC1 H105R Likely Oncogenic Loss-of-function 18397877 -TSC1 N198_F199delinsI Likely Oncogenic Loss-of-function 18830229, 11781698, 17304050 -TSC1 R509Q Likely Neutral Neutral 18830229 -TSC1 T417I Likely Neutral Neutral 18397877, 10570911, 10607950 -TSC1 V220F Likely Oncogenic Likely Loss-of-function 22923433 -TSC1 H206D Likely Oncogenic Loss-of-function 18397877 -TSC1 S35Q Likely Oncogenic Loss-of-function 18397877 -TSC1 F158C Likely Oncogenic Loss-of-function 18397877 -TSC1 R246K Likely Neutral Neutral 18830229 -TSC1 Deletion Likely Oncogenic Likely Loss-of-function 23485365, 24529379, 11741833, 10353610 -TSC1 K82T Likely Neutral Likely Neutral 23857276, 21309039 -TSC1 L117P Likely Oncogenic Loss-of-function 18830229 -TSC1 G305R Likely Neutral Neutral 18830229 -TSC1 G1035S Likely Neutral Neutral 18830229 -IKZF1 Deletion Likely Oncogenic Loss-of-function 27067989, 19129520, 27815723, 26202931 -TSC2 Truncating Mutations Likely Oncogenic Likely Loss-of-function 24529379, 14729330, 25724664, 14561707 -TSC2 V241del Oncogenic Loss-of-function 22903760 -TSC2 R505Q Likely Oncogenic Likely Loss-of-function 22903760 -TSC2 L493V Likely Oncogenic Likely Loss-of-function 22903760 -TSC2 E1552del Oncogenic Loss-of-function 22903760 -TSC2 V1673D Likely Oncogenic Likely Loss-of-function 22903760 -TSC2 F615S Likely Oncogenic Likely Loss-of-function 15483652, 11741832 -TSC2 G1596V Likely Oncogenic Likely Loss-of-function 22903760 -TSC2 V705M Likely Oncogenic Loss-of-function 22903760 -TSC2 R905G Likely Oncogenic Loss-of-function 17120248 -TSC2 Y598C Likely Oncogenic Likely Loss-of-function 22903760 -TSC2 L410R Oncogenic Loss-of-function 22903760 -TSC2 A889P Oncogenic Loss-of-function 22903760 -TSC2 H1620R Oncogenic Loss-of-function 22903760 -TSC2 L493P Likely Oncogenic Gain-of-function 22903760 -TSC2 S1498N Likely Oncogenic Likely Loss-of-function 15972957 -TSC2 L448P Likely Oncogenic Likely Loss-of-function 22903760 -TSC2 V299G Likely Oncogenic Likely Loss-of-function 22903760 -TSC2 T1623I Oncogenic Loss-of-function 22903760 -TSC2 V1673F Likely Oncogenic Likely Loss-of-function 22903760 -TSC2 H597Y Oncogenic Loss-of-function 22903760 -TSC2 R462C Likely Oncogenic Likely Loss-of-function 22903760 -TSC2 L1584R Likely Oncogenic Likely Loss-of-function 22903760 -TSC2 R905Q Likely Oncogenic Loss-of-function 17120248 -TSC2 E75G Likely Oncogenic Likely Loss-of-function 22903760, 27493206 -TSC2 A328P Likely Oncogenic Likely Loss-of-function 22903760 -TSC2 Deletion Oncogenic Likely Loss-of-function 11281455, 25724664, 26540169, 25281918, 14561707 -TSC2 C696Y Likely Oncogenic Loss-of-function 15483652, 11741832 -TSC2 Q1554H Likely Oncogenic Likely Loss-of-function 22903760 -TSC2 T1203K Oncogenic Loss-of-function 22903760 -TSC2 S1653P Oncogenic Loss-of-function 22903760 -TSC2 W1610G Likely Oncogenic Likely Loss-of-function 22903760 -TSC2 V769E Likely Oncogenic Loss-of-function 15483652, 11741832 -TSC2 S1653F Oncogenic Loss-of-function 22903760 -TSC2 V705E Oncogenic Loss-of-function 22903760 -TSC2 R1200W Likely Oncogenic Loss-of-function 21332470 -TSC2 L830R Oncogenic Loss-of-function 22903760 -TSC2 L826P Likely Oncogenic Likely Loss-of-function 15483652, 22903760 -TSC2 G1567D Likely Oncogenic Likely Loss-of-function 22903760 -TSC2 Y1571N Oncogenic Loss-of-function 22903760 -TSC2 L792R Oncogenic Loss-of-function 22903760 -TSC2 P1675L Likely Oncogenic Loss-of-function 11290735, 22903760, 12205112 -TSC2 R905W Likely Oncogenic Loss-of-function 17120248 -TSC2 S1036P Likely Oncogenic Likely Loss-of-function 21332470 -TSC2 P1709L Likely Oncogenic Likely Loss-of-function 22903760 -TSC2 L146R Likely Oncogenic Likely Loss-of-function 22903760 -TSC2 I427M Likely Oncogenic Likely Loss-of-function 22903760 -TSC2 R611Q Likely Oncogenic Loss-of-function 15483652, 11741832 -TSC2 A614D Likely Oncogenic Loss-of-function 15483652, 11741832 -TSC2 R611W Likely Oncogenic Loss-of-function 15483652, 11741832 -TSC2 Q1503P Likely Oncogenic Likely Loss-of-function 22903760 -TSC2 L844R Likely Oncogenic Likely Loss-of-function 22903760 -EWSR1 EWSR1-ATF1 Fusion Likely Oncogenic Likely Gain-of-function 24320889, 21822206, 25364450, 19801966 -EWSR1 EWSR1-CREB1 Fusion Likely Oncogenic Likely Gain-of-function 24320889, 21822206, 25364450, 19801966 -EWSR1 EWSR1-WT1 Fusion Oncogenic Gain-of-function 9591781, 11278460, 10999739, 11237525, 24321497 -EWSR1 EWSR1-ETV4 Fusion Likely Oncogenic Likely Gain-of-function 8605035 -EWSR1 EWSR1-ETV1 Fusion Oncogenic Gain-of-function 25109552 -EWSR1 EWSR1-FEV Fusion Likely Oncogenic Likely Gain-of-function 9121764 -EWSR1 EWSR1-DDIT3 Fusion Oncogenic Gain-of-function 24320889, 7805034, 24790523 -EWSR1 EWSR1-ERG Fusion Oncogenic Gain-of-function 18500345, 8162068, 10749119 -EWSR1 EWSR1-YY1 Fusion Oncogenic Gain-of-function 23630070 -EWSR1 EWSR1-NR4A3 Fusion Oncogenic Gain-of-function 22592656, 16604165 -EWSR1 Fusions Likely Oncogenic Likely Gain-of-function 8605035, 23329308, 21113140, 8834175 NCCN Bone Cancer. Volume# v.2017 https://www.nccn.org/professionals/physician_gls/pdf/bone.pdf -EWSR1 EWSR1-FLI1 Fusion Oncogenic Gain-of-function 17250957, 22930730, 24320889, 11715049, 25453903, 12432241 -ACVR1 R206H Likely Oncogenic Gain-of-function 24705254, 20463014, 22977237, 24769718 -ACVR1 G328E Likely Oncogenic Likely Gain-of-function 24705254, 20463014, 22977237, 24769718 -ACVR1 G328V Likely Oncogenic Gain-of-function 24705254, 20463014, 24705250, 24769718 -ACVR1 Q207E Likely Oncogenic Likely Gain-of-function 24852373 -FOXA1 L455M Likely Oncogenic Likely Loss-of-function 22722839 -FOXA1 Amplification Oncogenic Gain-of-function 22138582, 19470727, 22722839, 21147910, 22960745, 23622249, 19372580, 2298097, 23539448, 25079552, 12234996 -FOXA1 M253K Likely Oncogenic Likely Loss-of-function 23539448 -FOXA1 F400I Likely Oncogenic Likely Loss-of-function 22722839, 23539448 -FOXA1 G87R Likely Oncogenic Likely Loss-of-function 22722839 -FOXA1 S453fs* Likely Oncogenic Likely Gain-of-function 22722839 -FOXA1 L388M Likely Oncogenic Likely Loss-of-function 22722839 -FOXA1 Deletion Likely Oncogenic Likely Loss-of-function 24840332 -MDM2 Amplification Oncogenic Gain-of-function 9671804, 24667108, 15199139, 27194168 -ARID1A Truncating Mutations Likely Oncogenic Likely Loss-of-function 21900401, 24899687, 25625625 -ARID1A Deletion Likely Oncogenic Loss-of-function 22249247, 23097632, 21412130, 23208470 -EZH2 Amplification Oncogenic Gain-of-function 16330673, 12374981, 14500907, 21837672 -EZH2 A677G Likely Oncogenic Switch-of-function 22323599 -EZH2 Y646C Oncogenic Switch-of-function 21078963, 21190999 -EZH2 Y646N Oncogenic Switch-of-function 21078963, 21190999, 24469040, 21810159, 21843048 -EZH2 Y646F Oncogenic Switch-of-function 21078963, 21190999, 27135738, 24469040, 21810159, 21843048 -EZH2 Overexpression Oncogenic Gain-of-function 16330673, 12374981, 14500907, 21837672 -EZH2 Y646H Oncogenic Switch-of-function 21078963, 21190999 -EZH2 Y646S Oncogenic Switch-of-function 21078963, 21190999 -MDM4 G57A Oncogenic Loss-of-function 15199139, 9131587 -MDM4 Amplification Oncogenic Gain-of-function 9523192, 15199139, 7585611 -KLF4 K409Q Likely Oncogenic Likely Gain-of-function 23404370 -RXRA S247Y Inconclusive Inconclusive 24476821 -RXRA S247F Inconclusive Inconclusive 24476821 -MAP3K1 Truncating Mutations Likely Oncogenic Inconclusive 24003131, 24386504 -MAP3K1 E1286V Likely Neutral Likely Neutral 25899310 -MAP3K1 T779fs Likely Oncogenic Likely Loss-of-function 25899310 -MAP3K1 T1481fs Likely Oncogenic Likely Loss-of-function 25899310 -AXIN1 Truncating Mutations Likely Oncogenic Likely Loss-of-function 10700176, 25236910 -AXIN2 Truncating Mutations Likely Oncogenic Likely Loss-of-function 15802015, 17373666 -BAP1 Deletion Likely Oncogenic Likely Loss-of-function 21874000, 26246155, 24633195, 25970771 -BAP1 F81V Likely Oncogenic Loss-of-function 26680512 -BAP1 I47F Likely Oncogenic Loss-of-function 26680512 -BAP1 Truncating Mutations Likely Oncogenic Likely Loss-of-function 21874000, 18757409 -BAP1 E685V Likely Oncogenic Loss-of-function 25830670 -BAP1 C91S Oncogenic Loss-of-function 19815555, 9528852 -BAP1 C91A Likely Oncogenic Loss-of-function 18757409 -BAP1 F170I Likely Oncogenic Loss-of-function 26081045 -BAP1 A95D Likely Oncogenic Loss-of-function 26680512, 24894717, 18757409 -BAP1 G178V Likely Oncogenic Loss-of-function 24894717, 18757409 -MEN1 Truncating Mutations Likely Oncogenic Likely Loss-of-function -MEN1 Deletion Oncogenic Loss-of-function 12746426, 27076911, 9510467, 16740708, 21627674, 14633735, 12941803 -FANCA Deletion Likely Oncogenic Likely Loss-of-function 15522956, 12637330, 24689079, 8374893, 12827451, 14749703 -FANCA L274P Likely Oncogenic Loss-of-function 16720839 -FANCA S858R Likely Oncogenic Loss-of-function 12955722 -FANCA R1055L Likely Oncogenic Likely Loss-of-function 16720839 -FANCA L210R Likely Oncogenic Loss-of-function 16720839 -FANCA Truncating Mutations Likely Oncogenic Likely Loss-of-function 21273304, 15522956, 24689079, 12827451 -FANCA H492R Likely Oncogenic Loss-of-function 16720839, 12444097 -FANCA S1088F Likely Oncogenic Likely Loss-of-function Wilkes et al. Molecular Case Studies, 2016 http://molecularcasestudies.cshlp.org/content/early/2017/05/03/mcs.a001487.short -FANCA Y510C Likely Oncogenic Loss-of-function 16720839 -FANCA W183A Likely Oncogenic Loss-of-function 10468606, 11050007, 11161829 -FANCC Truncating Mutations Likely Oncogenic Likely Loss-of-function 11520787, 16687415, 20509860 -MET Y1230C Likely Oncogenic Gain-of-function 9826708, 18709663 -MET H1094R Oncogenic Gain-of-function 9563489 -MET D1010H Likely Oncogenic Likely Gain-of-function 27666659, 14559814, 16227611, 25898965, 25971938, 15735036, 27343443, 16397241, 26892698, 19096300 -MET X1009_splice Oncogenic Gain-of-function 15735036, 16397241, 19096300 -MET H1094Y Oncogenic Gain-of-function 15064724, 24061647 -MET E168D Likely Oncogenic Gain-of-function 19318576 Ma et al. Abstract# 14010 ASCO 2010 http://hwmaint.meeting.ascopubs.org/cgi/content/abstract/25/18_suppl/14010 -MET X1006_splice Oncogenic Gain-of-function 15735036, 16397241, 19096300 -MET L1195V Oncogenic Gain-of-function 15064724, 24061647 -MET T992I Likely Oncogenic Gain-of-function 25605252, 14559814, 21970370, 11042681, 22973954, 15735036, 17322284 -MET N1100Y Oncogenic Gain-of-function 12460923 -MET V1220I Likely Oncogenic Gain-of-function 19783361 -MET Y1003F Oncogenic Gain-of-function 16227611, 15123609, 11741535 -MET H1106D Likely Oncogenic Likely Gain-of-function 10327054 -MET X1008_splice Oncogenic Gain-of-function 15735036, 16397241, 19096300 -MET M1250T Oncogenic Gain-of-function 10327054, 10871851, 9826715, 15557554 -MET Y1003C Likely Oncogenic Likely Gain-of-function 16227611, 15123609, 11741535 -MET Y1230H Oncogenic Gain-of-function 27666659, 9826708, 9326629 -MET V1188L Oncogenic Gain-of-function 15064724, 24061647 -MET PTPRZ1-MET Fusion Likely Oncogenic Likely Gain-of-function 25135958 -MET F1200I Oncogenic Gain-of-function 24173966, 21697284 -MET Amplification Oncogenic Gain-of-function 16461907, 20129249, 19117057, 17667909, 22869872, 18077425, 17463250 -MET D1010Y Likely Oncogenic Likely Gain-of-function 27666659, 14559814, 16227611, 25898965, 25971938, 15735036, 27343443, 16397241, 19096300 -MET X963_splice Oncogenic Gain-of-function 15735036, 16397241, 19096300 -MET R970C Inconclusive Inconclusive 20670955, 14559814, 22973954 -MET Y1235D Oncogenic Gain-of-function 12460923, 10734314 -MET H1094L Oncogenic Gain-of-function 19783361, 24061647 -MET 963_D1010splice Oncogenic Gain-of-function 15735036, 16397241, 19096300 -MET D1010N Likely Oncogenic Likely Gain-of-function 26892698 -MET Overexpression Oncogenic Gain-of-function 9554529, 9870683, 8077049, 11381087, 15375530, 10698493 -MET V1070E Oncogenic Gain-of-function 25401301 -MET V1092I Oncogenic Gain-of-function 24061647, 10417759 -MET X1007_splice Oncogenic Gain-of-function 15735036, 16397241, 19096300 -MET D1228N Likely Oncogenic Likely Gain-of-function 9826708, 27343442 -MET N375S Inconclusive Inconclusive 16171945, 19723643 -MET Y1003* Likely Oncogenic Likely Gain-of-function 25079552, 16397241 -MET 981_1028splice Oncogenic Gain-of-function 15735036, 16397241, 19096300 -U2AF1 Q157R Oncogenic Switch-of-function 25267526, 25311244 -U2AF1 Q157P Likely Oncogenic Switch-of-function 25267526, 25311244 -U2AF1 S34Y Oncogenic Switch-of-function 22158538, 25267526, 25311244 -U2AF1 S34F Likely Oncogenic Switch-of-function 25965570, 22158538, 25267526, 25311244 -KMT2C Deletion Likely Oncogenic Likely Loss-of-function 23166019, 11891048, 24081332, 24794707, 9834205 -KMT2C Truncating Mutations Likely Oncogenic Likely Loss-of-function 23259788, 19433796, 25537518 -KMT2C A1685S Likely Oncogenic Loss-of-function 25998713, 25151357 -KMT2C S3660L Likely Neutral Likely Neutral 24965397 -PARP1 Truncating Mutations Likely Oncogenic Likely Loss-of-function -FAT1 P4309A Likely Oncogenic Likely Loss-of-function 23354438 -FAT1 A4419S Likely Oncogenic Likely Loss-of-function 23354438 -FAT1 T4511I Likely Oncogenic Likely Loss-of-function 23354438 -FAT1 Truncating Mutations Likely Oncogenic Likely Loss-of-function 24718888, 26905694, 23354438 -FAT1 Deletion Oncogenic Loss-of-function 21617878, 23354438 -ARID1B Truncating Mutations Likely Oncogenic Likely Loss-of-function 23660946, 22233809, 26340334 -ARID1B Deletion Likely Oncogenic Likely Loss-of-function 23202128, 25674384, 26340334 -PIK3CA E453K Oncogenic Gain-of-function 20593314, 21266528, 26627007 -PIK3CA N345K Oncogenic Gain-of-function 18074223, 20593314, 22949682, 17376864 -PIK3CA N1044K Oncogenic Gain-of-function 26627007 -PIK3CA M1043I Oncogenic Gain-of-function 22120714, 17376864 -PIK3CA G118D Likely Oncogenic Gain-of-function 22949682 -PIK3CA E81K Likely Oncogenic Likely Gain-of-function 25915946, 21266528 -PIK3CA M1043V Oncogenic Gain-of-function 17376864 -PIK3CA E542G Inconclusive Inconclusive 17990317, 25054828, 22553375, 25401499 -PIK3CA E545Q Oncogenic Gain-of-function 20593314, 26627007 -PIK3CA E453A Likely Oncogenic Likely Gain-of-function 20593314, 21266528 -PIK3CA I31M Likely Neutral Likely Neutral 26627007 -PIK3CA E110K Likely Oncogenic Likely Gain-of-function 23619167 -PIK3CA C420R Oncogenic Gain-of-function 18074223, 21266528, 22949682 -PIK3CA Q546P Oncogenic Gain-of-function 17626883, 17376864 -PIK3CA R38H Oncogenic Gain-of-function 15930273, 20593314, 17376864 -PIK3CA H1047L Oncogenic Gain-of-function 20593314, 26627007, 22120714, 17376864 -PIK3CA A1020V Likely Neutral Likely Neutral 26627007 -PIK3CA E545A Oncogenic Gain-of-function 20593314, 26627007, 17376864 -PIK3CA Q546K Oncogenic Gain-of-function 27126994, 17376864 -PIK3CA E545G Oncogenic Gain-of-function 20593314, 26627007, 17376864 -PIK3CA T1025S Oncogenic Gain-of-function 17376864 -PIK3CA P447_L455del Likely Oncogenic Likely Gain-of-function 27126994 -PIK3CA K111N Likely Oncogenic Likely Gain-of-function 18074223, 21266528, 26627007, 22949682, 17376864 -PIK3CA Q60K Likely Neutral Likely Neutral 18074223 -PIK3CA H701P Likely Neutral Likely Neutral 18074223, 17376864 -PIK3CA G106R Likely Oncogenic Gain-of-function 21266528 -PIK3CA E542K Oncogenic Gain-of-function 20593314, 16432179, 26627007, 17376864 -PIK3CA E365K Likely Oncogenic Gain-of-function 21266528 -PIK3CA C378R Likely Oncogenic Likely Gain-of-function 17363507 -PIK3CA V344G Inconclusive Inconclusive 27007084, 17050665, 24718026 -PIK3CA E542V Oncogenic Gain-of-function 26627007 -PIK3CA E453Q Likely Oncogenic Likely Gain-of-function 15930273, 20593314 -PIK3CA I391M Likely Neutral Likely Neutral 20530683 -PIK3CA Q546E Oncogenic Gain-of-function 26627007 -PIK3CA D350G Likely Oncogenic Gain-of-function 24265155 -PIK3CA V344A Likely Oncogenic Likely Gain-of-function 20593314, 21266528 -PIK3CA H1047Y Oncogenic Gain-of-function 20593314, 26627007, 17376864 -PIK3CA E116K Likely Neutral Likely Neutral 17376864 -PIK3CA H1047R Oncogenic Gain-of-function 16322248, 19029981, 22960745, 16341083, 22214849, 16432179, 26627007, 21822287, 27126994, 25079552, 22120714, 21324922, 23940356, 25631445, 20593314, 22941189, 22370636, 23787421, 23636398, 17376864 -PIK3CA P449_L455del Likely Oncogenic Gain-of-function 20593314, 21266528, 27126994 -PIK3CA D1029Y Likely Oncogenic Likely Gain-of-function 19394761 -PIK3CA R108H Likely Oncogenic Gain-of-function 18829572 -PIK3CA P539R Oncogenic Gain-of-function 17376864 -PIK3CA R93Q Likely Oncogenic Likely Gain-of-function 21266528 -PIK3CA E545K Oncogenic Gain-of-function 16322248, 20593314, 16432179, 26627007, 17376864 -PIK3CA G106_R108del Likely Oncogenic Likely Gain-of-function 19394761 -PIK3CA R93W Likely Oncogenic Gain-of-function 20593314, 21266528, 22949682 -PIK3CA R115L Likely Neutral Likely Neutral 23619167 -PIK3CA G106V Likely Oncogenic Gain-of-function 15930273, 21266528 -PIK3CA P449T Oncogenic Gain-of-function 20530683 -PIK3CA K111E Oncogenic Gain-of-function 18074223, 21266528, 22949682 -PIK3CA N345I Likely Oncogenic Likely Gain-of-function 20593314, 26627007 -PIK3CA G106D Likely Oncogenic Likely Gain-of-function 27555788, 15930273, 21266528 -PIK3CA A1066V Likely Neutral Likely Neutral 27465249, 22430209 -PIK3CA E78K Inconclusive Inconclusive 27126994 -PIK3CA Q546R Oncogenic Gain-of-function 17626883, 26627007 -PIK3CA G914R Likely Oncogenic Likely Gain-of-function 22228622, 22729224 -PIK3CA Amplification Likely Oncogenic Likely Gain-of-function 21720365, 22960745, 17992665, 23136191, 19706770, 22292935, 22994622, 19697359, 25631445, 24608574, 26876212, 23636398, 27095573, 17803655 Zehir A et al. Nature Medicine, 2017 http://doi:10.1038/nm.4333 -PIK3CA N1068fs*4 Likely Oncogenic Gain-of-function 21703185 -PIK3CA E542Q Likely Oncogenic Likely Gain-of-function 16432179, 26627007, 17376864 -PIK3CA E579K Likely Oncogenic Likely Gain-of-function 17376864 -PIK3CA R88Q Likely Oncogenic Gain-of-function 22949682 -PIK3CB R48W Likely Oncogenic Likely Gain-of-function 18755892, 26000489 -PIK3CB D1067V Oncogenic Gain-of-function 25982275 -PIK3CB E1051K Likely Oncogenic Likely Gain-of-function 18755892, 26000489 -PIK3CB E552K Likely Oncogenic Gain-of-function 16339315 -PIK3CB E633K Likely Oncogenic Likely Gain-of-function 23734178, 20668451 -PIK3CB D1067A Likely Oncogenic Gain-of-function 26759240 -PIK3CB ACPP-PIK3CB Fusion Likely Oncogenic Likely Gain-of-function 26000489, 16432180 -PIK3CB N553S Likely Oncogenic Likely Gain-of-function 18755892, 26000489 -PIK3CB D1067Y Oncogenic Gain-of-function 26759240 -PIK3CB Fusions Likely Oncogenic Likely Gain-of-function 26000489, 16432180 -PIK3CB Amplification Oncogenic Gain-of-function 24418330, 26442967, 16432180, 25533673 -PIM1 E142D Inconclusive Inconclusive 23755147 -PIM1 P123M Likely Neutral Likely Neutral 15808862 -PIM1 L193F Likely Oncogenic Likely Loss-of-function 15808862 -PIM1 N82K Likely Neutral Likely Loss-of-function 15808862 -PIM1 P81S Likely Oncogenic Likely Loss-of-function 15808862 -PIM1 Y53H Inconclusive Inconclusive 23755147 -PIM1 E124Q Inconclusive Inconclusive 23755147 -PIM1 H68Y Likely Oncogenic Likely Gain-of-function 15808862 -PIM1 E135K Inconclusive Inconclusive 23755147, 15808862, 19734423 -PIK3CD E525K Likely Oncogenic Gain-of-function 24136356, 24165795 -PIK3CD E1021K Likely Oncogenic Gain-of-function 24136356, 24165795 -PIK3CD N334K Likely Oncogenic Gain-of-function 24165795 -YAP1 Fusions Likely Oncogenic Likely Gain-of-function 23737213, 25965568, 24553141 -YAP1 Amplification Oncogenic Gain-of-function 16140918, 15586366, 16814713, 24336504, 19952108, 15824737, 8569172, 10092132, 17114655, 20842732, 23502453, 24511017, 12651874, 12208731, 19551889 -YAP1 YAP1-MAMLD1 Fusion Likely Oncogenic Likely Gain-of-function 25965575 -YAP1 YAP1-FAM118B Fusion Likely Oncogenic Likely Gain-of-function 25965575 -YAP1 YAP1-TFE3 Fusion Likely Oncogenic Likely Gain-of-function 23737213 -PIK3R1 E137K Likely Oncogenic Likely Loss-of-function 24367658 -PIK3R1 R574fs Oncogenic Loss-of-function 20713702 -PIK3R1 R348* Oncogenic Loss-of-function 21478295, 25284480, 21984976 -PIK3R1 Deletion Likely Oncogenic Likely Loss-of-function 24229379, 25488983, 25133428 -PIK3R1 W237_Y242del Likely Oncogenic Likely Loss-of-function 24367658 -PIK3R1 T576del Oncogenic Loss-of-function 20713702 -PIK3R1 Q579_L581del Oncogenic Loss-of-function 19962665 -PIK3R1 K379E Oncogenic Loss-of-function 20713702 -PIK3R1 E439del Likely Oncogenic Loss-of-function 20713702 -PIK3R1 R262T Likely Oncogenic Likely Loss-of-function 24367658 -PIK3R1 X434_splice Likely Oncogenic Loss-of-function 25488983, 25133428 -PIK3R1 N564D Oncogenic Loss-of-function 24367658 -PIK3R1 D560Y Likely Oncogenic Loss-of-function 20713702 -PIK3R1 R503W Oncogenic Loss-of-function 25957691, 21984976 -PIK3R1 G376R Likely Oncogenic Loss-of-function 20713702 -PIK3R1 X475_splice Likely Oncogenic Loss-of-function 25488983, 25133428 -PIK3R1 E218* Likely Oncogenic Likely Loss-of-function 24367658 -PIK3R1 K459_S460delinsN Oncogenic Loss-of-function 20713702 -PIK3R1 R162* Likely Oncogenic Likely Loss-of-function 24367658 -PIK3R1 E160* Oncogenic Loss-of-function 25284480, 21984976 -PIK3R1 Truncating Mutations Likely Oncogenic Likely Loss-of-function 25488983, 25284480, 25133428 -PIK3R1 X582_splice Likely Oncogenic Likely Loss-of-function 25488983, 25284480, 25133428 -PIK3R1 N564K Likely Oncogenic Loss-of-function 20713702 -PIK3R1 K288Q Likely Oncogenic Likely Loss-of-function 24367658 -PIK3R1 L370fs Likely Oncogenic Likely Loss-of-function 25284480 -PIK3R1 I559_D560insDKRMNS Oncogenic Loss-of-function 20713702 -PIK3R2 A36E Likely Neutral Likely Neutral 21984976 -PIK3R2 A171V Oncogenic Gain-of-function 21984976 -PIK3R2 K376N Inconclusive Inconclusive 21984976 -PIK3R2 N561D Oncogenic Gain-of-function 21984976 -PIK3R2 G373R Likely Oncogenic Gain-of-function 26520804, 22729224 -PIK3R2 Amplification Likely Oncogenic Likely Gain-of-function 25502460 -PIK3R2 A727V Likely Neutral Likely Neutral 21984976 -PIK3R2 D557H Likely Oncogenic Likely Loss-of-function 26860062, 26520804 -PIK3R2 S273C Likely Neutral Likely Neutral 21984976 -ARID5B Truncating Mutations Likely Oncogenic Likely Loss-of-function Kawamata and Itakura Abstract# LB-150, AACR 2016 http://cancerres.aacrjournals.org/content/76/14_Supplement/LB-150 -HRAS T58I Likely Oncogenic Likely Gain-of-function 26888048 -HRAS A146T Oncogenic Gain-of-function 17054105, 19075190, 20570890, 20147967, 2403644 -HRAS G13V Likely Oncogenic Likely Gain-of-function 9219684, 21993244, 22589270, 18713003 -HRAS K117N Likely Oncogenic Likely Gain-of-function 20570890 -HRAS G13D Likely Oncogenic Likely Gain-of-function 26561417, 9219684, 26037647, 21993244, 22722830, 20147967 -HRAS F28L Likely Oncogenic Gain-of-function 25600866 -HRAS Q61K Oncogenic Gain-of-function 10574788, 18073111, 9219684, 21993244, 20194776 -HRAS A59G Likely Oncogenic Gain-of-function 17084704, 20838576 -HRAS Q22K Likely Oncogenic Likely Gain-of-function 17412879 -HRAS G12A Likely Oncogenic Likely Gain-of-function 9219684, 21993244, 25013473 -HRAS G12D Oncogenic Gain-of-function 9219684, 21993244, 24123531 -HRAS A59T Likely Oncogenic Likely Gain-of-function 1730690 -HRAS G12S Oncogenic Gain-of-function 9219684, 21993244, 20979192, 25284075, 24129065 -HRAS G12V Oncogenic Gain-of-function 9219684, 21993244, 24240680, 22589270 -HRAS Q61H Likely Oncogenic Likely Gain-of-function 10574788, 25705018, 9219684, 21993244, 20194776, 20147967 -HRAS Q61R Likely Oncogenic Likely Gain-of-function 10574788, 9219684, 21993244, 20194776, 25437878 -HRAS A146V Likely Oncogenic Likely Gain-of-function 18247425 -HRAS Q61L Oncogenic Gain-of-function 22256804, 10574788, 9219684, 21993244, 20194776 -HRAS Amplification Likely Oncogenic Likely Gain-of-function 8221670, 3283542, 1855225 -HRAS G13R Likely Oncogenic Likely Gain-of-function 9219684, 21993244 -HRAS G12C Likely Oncogenic Likely Gain-of-function 25705018, 9219684, 21993244, 24256730, 16051643, 26841430 -HRAS P34R Likely Oncogenic Likely Gain-of-function 16474404, 8246952 -HRAS Y64A Likely Oncogenic Likely Gain-of-function 24516166 -HRAS K117R Oncogenic Gain-of-function 17054105, 16443854, 20570890, 24247240, 20147967 -HRAS G13C Likely Oncogenic Likely Gain-of-function 25705018, 9219684, 21993244, 17211612, 21079152 -MLH1 M587V Inconclusive Inconclusive 18206535 -MLH1 R487* Likely Oncogenic Likely Loss-of-function 24362816, 16216036, 15713769 -MLH1 P648S Inconclusive Inconclusive 23435383, 24362816 -MLH1 G67R Likely Oncogenic Likely Loss-of-function 21120944 -MLH1 V716M Likely Neutral Likely Neutral 24362816, 21120944 -MLH1 L749P Inconclusive Inconclusive 23435383, 24362816 -MLH1 L550P Likely Oncogenic Likely Loss-of-function 23435383, 24362816 -MLH1 L622H Inconclusive Inconclusive 23435383, 24362816 -MLH1 L559R Inconclusive Inconclusive 23435383, 24362816 -MLH1 T117M Likely Oncogenic Loss-of-function 24362816, 8566964, 12919140, 11781295 -MLH1 R659P Inconclusive Inconclusive 23435383 -MLH1 K618T Likely Neutral Likely Neutral 24362816, 19863800 -MLH1 K618A Likely Oncogenic Likely Loss-of-function 22426235, 24362816, 18205192 -MLH1 R659L Likely Oncogenic Likely Loss-of-function 23435383 -MLH1 V384D Likely Neutral Likely Neutral 12037578, 24362816 -MLH1 Q689R Likely Neutral Likely Neutral 24362816, 25092538 -MLH1 A120S Oncogenic Loss-of-function 24755471 -MLH1 R659* Oncogenic Loss-of-function 23435383 -MLH1 I219V Likely Neutral Likely Neutral 24362816, 11781295 -MLH1 P648L Likely Oncogenic Loss-of-function 23435383, 24362816 -MLH1 V506A Inconclusive Inconclusive 23435383, 24362816 -MLH1 R265C Oncogenic Loss-of-function 19419416, 18205192, 11781295 -MLH1 N551T Likely Oncogenic Likely Loss-of-function 23435383, 24362816 -MLH1 R217C Likely Neutral Likely Neutral 12810663, 17510385, 11781295 -MLH1 A111P Likely Oncogenic Likely Loss-of-function 20020535 -MLH1 G67W Likely Oncogenic Loss-of-function 16528606, 24362816, 17510385, 9927034 -MLH1 D737V Inconclusive Inconclusive 23435383, 24362816 -MLH1 E172K Inconclusive Inconclusive 24755471, 20668451 -MLH1 P654L Inconclusive Inconclusive 23435383 -MLH1 Truncating Mutations Likely Oncogenic Likely Loss-of-function 12697830, 7892206, 11781295 -MLH1 T82A Likely Oncogenic Loss-of-function 24362816, 22736432 -MLH1 R265S Likely Oncogenic Likely Loss-of-function 20020535, 17210669, 24362816 -MLH1 W714* Likely Oncogenic Loss-of-function 23435383, 24362816 -MLH1 R725C Inconclusive Inconclusive 24362816, 23403630 -MLH1 G101S Likely Oncogenic Likely Loss-of-function 22290698, 24362816, 24278394 -MLH1 L582F Inconclusive Inconclusive 23435383, 24362816 -MLH1 R100* Likely Oncogenic Loss-of-function 15872200, 14512394 -MLH1 R226* Likely Oncogenic Likely Loss-of-function 11343035, 24362816, 9927033 -MLH1 R755S Likely Oncogenic Likely Loss-of-function 23435383, 24362816 -FGF3 Amplification Inconclusive Inconclusive 24265351, 22890726, 10845805, 9205106 -FGF4 Amplification Inconclusive Inconclusive 24265351, 22890726 -KMT2A Truncating Mutations Likely Oncogenic Likely Loss-of-function 25998713 -KMT2A Fusions Likely Oncogenic Likely Gain-of-function 25998713, 23628958, 8681380, 11265751, 18455126 -KMT2A Amplification Inconclusive Inconclusive 17908926, 15378024 -AKT1 Q79E Oncogenic Gain-of-function 23134728 -AKT1 D32Y Likely Neutral Likely Neutral 23134728, 23237847, 19706770 -AKT1 Amplification Likely Oncogenic Gain-of-function 14655756, 12631397, 1409633, 24896186, 17616691, 3037531, 11485901 -AKT1 R23A Oncogenic Gain-of-function 23134728 -AKT1 W80A Likely Oncogenic Gain-of-function 25856301, 18669636, 25551293 -AKT1 G311D Likely Oncogenic Likely Switch-of-function 25551293, 22460905 -AKT1 V270A Oncogenic Gain-of-function 23134728 -AKT1 E17K Oncogenic Gain-of-function 23134728, 20440266, 23741320, 18256540, 21793738, 17611497, 9843996 -AKT1 K39N Likely Neutral Likely Neutral 23134728, 23237847, 19706770 -AKT1 L362R Likely Neutral Neutral 23134728 -AKT1 E191A Oncogenic Gain-of-function 23134728 -AKT1 L321A Oncogenic Gain-of-function 23134728 -AKT1 L52R Oncogenic Gain-of-function 23134728, 27147599, 20886116 -AKT1 T195I Oncogenic Gain-of-function 23134728 -AKT1 D325A Oncogenic Gain-of-function 23134728 -AKT1 E267G Likely Oncogenic Likely Gain-of-function 27147599 -AKT1 L78T Oncogenic Gain-of-function 23134728 -AKT1 R200A Likely Neutral Neutral 23134728 -AKT1 K189N Oncogenic Gain-of-function 23134728 -AKT1 Q79K Likely Oncogenic Gain-of-function 23134728, 20886116, 24265152 -AKT1 K179M Likely Oncogenic Likely Switch-of-function 7774014, 25551293 -AKT1 C77F Likely Oncogenic Likely Gain-of-function 22722193, 23237847 -AKT1 V271A Oncogenic Gain-of-function 23134728 -AKT1 R370C Likely Oncogenic Likely Gain-of-function 27147599 -AKT1 R328A Oncogenic Gain-of-function 23134728 -AKT1 E49K Oncogenic Gain-of-function 19802009 -AKT1 P42T Likely Neutral Likely Neutral 23134728, 23237847, 19706770 -AKT1 L202F Likely Neutral Neutral 23134728 -AKT1 N53A Oncogenic Gain-of-function 23134728 -AKT1 Q59E Likely Neutral Neutral 23134728 -AKT1 E40K Oncogenic Gain-of-function 9690513, 9843996 -AKT1 D323H Likely Oncogenic Gain-of-function 23134728, 20886116 -AKT2 G161V Likely Oncogenic Switch-of-function 25551293 -AKT2 D399N Likely Oncogenic Gain-of-function 19738612 -AKT2 Amplification Oncogenic Gain-of-function 8622988 -AKT2 E17K Oncogenic Gain-of-function 19372382, 24285683, 21979934, 17611497 -AKT2 I289M Oncogenic Gain-of-function 25551293 -AKT2 R368C Likely Oncogenic Gain-of-function 19738612, 25551293 -AKT2 D32H Likely Oncogenic Gain-of-function 19738612 -AKT2 BCAM-AKT2 Fusion Likely Oncogenic Gain-of-function 25733895 -AKT2 K181M Likely Oncogenic Switch-of-function 25551293 -AKT2 H355M Oncogenic Gain-of-function 25551293 -AKT2 R170W Oncogenic Gain-of-function 25551293 -AKT2 Fusions Likely Oncogenic Likely Gain-of-function 25733895 -FGFR1 E664K Likely Neutral Likely Loss-of-function 19733072 -FGFR1 FGFR1-TACC1 Fusion Oncogenic Gain-of-function 22837387, 23558953 -FGFR1 N546K Oncogenic Gain-of-function 24777483, 24806303, 19224897, 24705251, 22820256, 16186508, 23817572, 24140581, 14602678 -FGFR1 Amplification Oncogenic Gain-of-function 24265351, 23658459, 22960745, 26451490, 15863030, 15863033, 21160078, 24476821, 25677745, 17121884 -FGFR1 ERLIN2?FGFR1 Fusion Likely Oncogenic Gain-of-function 23558953 -FGFR1 BCR-FGFR1 Fusion Likely Oncogenic Gain-of-function 11739186, 20226962 -FGFR1 ZNF198-FGFR1 Fusion Likely Oncogenic Gain-of-function 20226962, 10887137, 10935490 -FGFR1 K656E Likely Oncogenic Gain-of-function 15509736, 23817572 -FGFR1 A263V Likely Neutral Likely Neutral 26826182 -FGFR1 Fusions Likely Oncogenic Likely Gain-of-function 23558953 -FGFR1 FGFR1OP1-FGFR1 Fusion Likely Oncogenic Gain-of-function 11689702, 16690081, 21330321, 20226962 -FGFR1 V561M Likely Oncogenic Likely Gain-of-function 15157880, 25686244 -FGFR1 CEP110-FGFR1 Fusion Likely Oncogenic Gain-of-function 10688839, 20226962 -FGFR1 CUX1-FGFR1 Fusion Likely Oncogenic Gain-of-function 21330321 -FGFR3 FGFR3 - BAIAP2L1 Fusion Oncogenic Gain-of-function 23175443 -FGFR3 I538F Likely Neutral Likely Neutral 26992226 -FGFR3 K650T Likely Oncogenic Likely Gain-of-function 11055896, 19749790 -FGFR3 V555M Likely Oncogenic Gain-of-function 26992226 -FGFR3 P572A Likely Neutral Likely Neutral 26992226 -FGFR3 FGFR3-TACC3 Fusion Oncogenic Gain-of-function 25609060, 22837387 -FGFR3 G380R Likely Oncogenic Gain-of-function 12461689, 10646125, 10611230, 21324899 -FGFR3 I538V Likely Oncogenic Gain-of-function 26992226 -FGFR3 N653H Likely Neutral Likely Neutral 26992226 -FGFR3 G697C Likely Neutral Likely Neutral 26992226 -FGFR3 D646Y Likely Neutral Likely Neutral 26992226 -FGFR3 F384L Likely Neutral Likely Neutral 11157491 -FGFR3 A500T Likely Neutral Likely Neutral 26992226 -FGFR3 K650E Likely Oncogenic Gain-of-function 19749790, 11429702 -FGFR3 H643D Likely Neutral Likely Neutral 26992226 -FGFR3 Y647C Likely Oncogenic Likely Gain-of-function 26992226 -FGFR3 A391E Likely Oncogenic Gain-of-function 23437153 -FGFR3 R669G Likely Oncogenic Gain-of-function 26992226 -FGFR3 V677I Likely Neutral Likely Neutral 26992226 -FGFR3 Y373C Oncogenic Gain-of-function 19749790, 16338952, 11429702 -FGFR3 K650R Likely Oncogenic Likely Gain-of-function 11055896, 19749790 -FGFR3 Fusions Likely Oncogenic Likely Gain-of-function 23298836, 23661334, 23558953 -FGFR3 G370C Likely Oncogenic Gain-of-function 12009017 -FGFR3 D641G Likely Oncogenic Gain-of-function 26992226 -FGFR3 N540K Oncogenic Gain-of-function 26992226 -FGFR3 K650M Likely Oncogenic Likely Gain-of-function 11055896, 19749790, 10053006 -FGFR3 S371C Likely Oncogenic Gain-of-function 12009017 -FGFR3 E466K Likely Neutral Likely Neutral 26992226 -FGFR3 G375C Likely Oncogenic Gain-of-function 22529939 -FGFR3 S249C Oncogenic Gain-of-function 19749790, 16338952, 17384684 -FGFR3 K650Q Likely Oncogenic Likely Gain-of-function 11055896, 19749790 -FGFR3 Amplification Oncogenic Gain-of-function 17344846, 20094046, 19821490 -FGFR3 C582F Likely Neutral Likely Neutral 26992226 -FGFR3 IGH-FGFR3 Fusion Oncogenic Gain-of-function 17107900 -FGFR3 K650N Likely Oncogenic Likely Gain-of-function 11055896, 19749790 -FGFR3 R248C Oncogenic Gain-of-function 22203368, 8640234 -FGFR3 K508M Inconclusive Inconclusive 22837387 -FGFR3 G637W Likely Neutral Likely Loss-of-function 26992226 -FGFR3 E627D Likely Neutral Likely Neutral 26992226 -FGFR3 D641N Likely Oncogenic Gain-of-function 26992226 -FGFR3 D617G Likely Neutral Likely Loss-of-function 26992226 -FGFR3 N540S Likely Oncogenic Gain-of-function 26992226 -FGFR3 G382D Likely Oncogenic Likely Gain-of-function 11429702 -SPOP P94A Likely Oncogenic Loss-of-function 19818708, 18218622, 25766326 -SPOP M117I Likely Oncogenic Loss-of-function 19818708, 18218622, 25766326 -SPOP E47K Likely Oncogenic Loss-of-function 19818708, 18218622, 25766326 -SPOP W131A Likely Oncogenic Likely Loss-of-function 19818708, 18218622 -SPOP F133L Likely Oncogenic Loss-of-function 19818708, 18218622, 25274033, 24508459, 23559371 -SPOP S80R Likely Oncogenic Loss-of-function 19818708, 18218622, 25766326 -SPOP N296I Likely Oncogenic Likely Loss-of-function 19818708, 23559371, 24796539 -SPOP D130A Likely Oncogenic Likely Loss-of-function 19818708, 18218622, 22085717 -SPOP Y87N Likely Oncogenic Loss-of-function 19818708, 18218622, 25274033, 24508459, 23559371 -SPOP F102C Likely Oncogenic Loss-of-function 19818708, 18218622, 25274033, 24508459, 23559371 -SPOP E50K Likely Oncogenic Loss-of-function 19818708, 18218622, 25766326 -SPOP R121Q Likely Oncogenic Loss-of-function 19818708, 18218622, 25766326 -SPOP G75R Likely Oncogenic Loss-of-function 19818708, 18218622, 25766326 -SPOP Y87C Likely Oncogenic Loss-of-function 19818708, 18218622, 25274033, 24508459, 23559371 -SPOP D140G Likely Oncogenic Loss-of-function 19818708, 18218622, 25766326 -SPOP W131G Likely Oncogenic Loss-of-function 19818708, 18218622, 25274033, 24508459, 23559371 -SPOP M117V Likely Oncogenic Loss-of-function 19818708, 18218622, 25766326 -SPOP K134N Likely Oncogenic Likely Loss-of-function 19818708, 18218622, 24990631 -SPOP Truncating Mutations Likely Oncogenic Likely Loss-of-function 26344095 -SPOP F133V Likely Oncogenic Loss-of-function 19818708, 18218622, 25274033, 24508459, 23559371 -SPOP K129E Likely Oncogenic Likely Loss-of-function 19818708, 18218622, 24990631 -SPOP F125V Likely Oncogenic Loss-of-function 19818708, 18218622, 25274033, 24508459, 23559371 -SPOP S119N Likely Oncogenic Loss-of-function 19818708, 18218622, 25274033, 24508459, 23559371 -FGFR2 Y375C Likely Oncogenic Gain-of-function 22585574, 22558232 -FGFR2 C278F Likely Oncogenic Likely Loss-of-function 20004243, 16844695 -FGFR2 H213Y Inconclusive Inconclusive 19147536 -FGFR2 K525E Likely Oncogenic Gain-of-function 17803937 -FGFR2 FGFR2-BICC1 Fusion Oncogenic Gain-of-function 24122810, 23558953 -FGFR2 V564I Oncogenic Gain-of-function 23908597 -FGFR2 FGFR2-MGEA5 Fusion Likely Oncogenic Likely Gain-of-function 24550739 -FGFR2 Amplification Oncogenic Gain-of-function 20094046, 20101236 -FGFR2 I642V Likely Oncogenic Likely Loss-of-function 19147536 -FGFR2 E219K Likely Oncogenic Likely Loss-of-function 19147536 -FGFR2 S267_D273dup Oncogenic Gain-of-function 26048680 -FGFR2 W290_I291delinsC Oncogenic Gain-of-function 26048680 -FGFR2 R203C Likely Oncogenic Gain-of-function 23527311, 15908952 -FGFR2 T341P Likely Oncogenic Gain-of-function 9539778 -FGFR2 FGFR2-FAM76A Fusion Oncogenic Gain-of-function 24563622 -FGFR2 N549T Likely Oncogenic Gain-of-function 17803937 -FGFR2 E565G Likely Oncogenic Gain-of-function 23908597 -FGFR2 FGFR2-TACC3 Fusion Oncogenic Gain-of-function 26048680 -FGFR2 FGFR2-AHCYL1 Fusion Oncogenic Gain-of-function 24122810 -FGFR2 E731K Likely Oncogenic Gain-of-function 21928350 -FGFR2 L617F Likely Oncogenic Gain-of-function 23913723 -FGFR2 M535I Oncogenic Gain-of-function 23908597 -FGFR2 K659N Likely Oncogenic Gain-of-function 17803937, 23527311, 17525745 -FGFR2 T730S Likely Neutral Likely Neutral 26048680 -FGFR2 L770V Inconclusive Inconclusive 19147536 -FGFR2 K517R Likely Neutral Likely Loss-of-function 19147536 -FGFR2 G271E Likely Oncogenic Likely Loss-of-function 19147536 -FGFR2 N549K Oncogenic Gain-of-function 23908597, 17525745, 18552176 -FGFR2 K310R Likely Neutral Likely Neutral 18552176 -FGFR2 L617M Oncogenic Gain-of-function 23908597 -FGFR2 N549H Oncogenic Gain-of-function 23908597 -FGFR2 D530N Likely Oncogenic Likely Loss-of-function 19147536 -FGFR2 A648T Likely Oncogenic Likely Loss-of-function 19147536 -FGFR2 K659E Likely Oncogenic Likely Gain-of-function 17525745 -FGFR2 D101Y Likely Oncogenic Likely Gain-of-function 18552176 -FGFR2 K526E Likely Oncogenic Likely Gain-of-function 17803937, 16061565 -FGFR2 C382R Oncogenic Gain-of-function 9136983, 17525745 -FGFR2 P253R Oncogenic Gain-of-function 24265351, 11121055 -FGFR2 N549S Oncogenic Gain-of-function 23908597 -FGFR2 FGFR2-KIAA1967 Fusion Likely Oncogenic Likely Gain-of-function 23558953 -FGFR2 Fusions Likely Oncogenic Likely Gain-of-function 25608663, 26258846, 23558953 -FGFR2 K641N Likely Oncogenic Likely Gain-of-function 23908597 -FGFR2 S252W Oncogenic Gain-of-function 17525745, 18552176 -FGFR2 M391R Likely Oncogenic Gain-of-function 24908667 -FGFR2 FGFR2-CCDC6 Fusion Likely Oncogenic Gain-of-function 23558953 -FGFR2 A389T Likely Neutral Likely Neutral 18552176 -FGFR2 V248D Inconclusive Inconclusive 19147536 -FGFR2 V755I Likely Neutral Likely Neutral 26048680 -FGFR2 FGFR2-CIT Fusion Likely Oncogenic Likely Gain-of-function 23558953 -FGFR2 G701S Inconclusive Inconclusive 19147536 -FGFR2 E475K Likely Neutral Likely Neutral 19147536 -FGFR2 FGFR2?PPHLN1 Fusion Oncogenic Gain-of-function 25608663 -FGFR2 R251Q Likely Oncogenic Likely Loss-of-function 19147536 -FGFR2 K641R Likely Oncogenic Gain-of-function 17803937, 23527311 -FGFR2 E636K Inconclusive Inconclusive 19147536 -FGFR4 Y367C Oncogenic Gain-of-function 19946327 -FGFR4 Amplification Oncogenic Gain-of-function 15863030, 25053532, 20094046, 23344261 -FGFR4 V550E Oncogenic Gain-of-function 19809159, 25219510 -FGFR4 N535K Oncogenic Gain-of-function 19809159 -KDM6A Deletion Likely Oncogenic Likely Loss-of-function 19330029, 25225064, 27028180, 22197486 Walker et al. Abstract #1798, ASH, 2009 http://www.bloodjournal.org/content/114/22/1798?sso-checked=true -KDM6A Truncating Mutations Likely Oncogenic Likely Loss-of-function 19330029, 24633898, 25225064 -ALK I1183T Likely Neutral Neutral 21383740, 25517749 -ALK G1202R Oncogenic Gain-of-function 22277784, 21383740, 26144315, 26698910, 24736079, 24675041 -ALK RANBP2-ALK Fusion Oncogenic Gain-of-function 21030459, 20979472 -ALK G1269S Oncogenic Gain-of-function 22277784, 21383740, 22034911, 24675041 -ALK L1198P Oncogenic Gain-of-function 21948233, 21383740 -ALK L1122V Oncogenic Gain-of-function 21383740, 25421750 -ALK I1171N Oncogenic Gain-of-function 21383740, 25517749, 27049722, 24491302, 25749034 -ALK T1343I Likely Neutral Likely Neutral 21383740, 25517749 -ALK S1206Y Oncogenic Gain-of-function 22277784, 21383740, 26144315, 24675041 -ALK N1178H Oncogenic Gain-of-function 21383740, 25749034 -ALK P1139S Oncogenic Gain-of-function 21383740, 25421750 -ALK RANBP1-ALK Fusion Oncogenic Gain-of-function 21030459 -ALK D1091N Likely Oncogenic Likely Gain-of-function 21383740, 18923525, 23104988, 26786851, 18724359 -ALK H694R Likely Oncogenic Gain-of-function 21847362 -ALK R1192P Oncogenic Gain-of-function 27009859, 21383740, 25517749, 27049722 -ALK G1269A Oncogenic Gain-of-function 22235099, 27009859, 26849637, 23401436, 21948233, 22277784, 21383740, 27049722, 26144315, 26698910, 24675041 -ALK R1464* Likely Neutral Neutral 21383740, 23104988 -ALK S1206C Oncogenic Gain-of-function 21383740, 25421750 -ALK A1234T Likely Neutral Likely Neutral 21383740, 23104988 -ALK V597A Likely Oncogenic Gain-of-function 21847362, 12855999 -ALK R1275L Likely Oncogenic Likely Gain-of-function 23598171 -ALK G1128S Oncogenic Gain-of-function 25749034 -ALK L1240V Oncogenic Gain-of-function 21383740, 23104988 -ALK G1201E Oncogenic Gain-of-function 21383740, 21596819 -ALK R1275Q Oncogenic Gain-of-function 18923523, 21383740, 18923525, 25517749, 26829053, 27049722, 26554404, 22072639 -ALK D1349H Likely Neutral Likely Neutral 21383740, 25517749 -ALK L1152R Oncogenic Gain-of-function 21791641, 21383740, 26144315 -ALK STRN-ALK Fusion Likely Oncogenic Likely Gain-of-function 24613930 -ALK G1128A Oncogenic Gain-of-function 21383740, 25517749, 27049722 -ALK L1196M Oncogenic Gain-of-function 22235099, 23434628, 22277784, 21383740, 25517749, 26144315, 20979473, 26698910, 22034911, 25421750, 21613408, 24675041 -ALK NPM-ALK Fusion Oncogenic Gain-of-function 26133723, 18923525, 26144315, 12424201, 25421750, 12879008, 21613408 -ALK G881D Likely Oncogenic Gain-of-function 21847362 -ALK F1245V Oncogenic Gain-of-function 21383740, 25517749 -ALK C1156F Oncogenic Gain-of-function 21383740, 25749034 -ALK C1156Y Oncogenic Gain-of-function 22235099, 21383740, 26144315, 20979473, 26698910, 25749034, 21613408, 24675041 -ALK Q1064R Oncogenic Gain-of-function 21383740, 25421750 -ALK G1123D Oncogenic Gain-of-function 21948233, 21383740 -ALK I1170S Oncogenic Gain-of-function 21383740, 25517749 -ALK I1250T Likely Neutral Likely Neutral 21383740, 25517749 -ALK E1384K Likely Oncogenic Gain-of-function 21847362 -ALK L1204F Likely Neutral Neutral 21383740, 23104988 -ALK M1328I Oncogenic Gain-of-function 21383740, 24491302 -ALK F1174V Oncogenic Gain-of-function 18923523, 21383740, 27049722, 25421750 -ALK I1171T Oncogenic Gain-of-function 25228534, 21383740, 22034911, 25749034, 24675041, 25736571 -ALK G1286R Likely Neutral Neutral 21383740, 25517749 -ALK I1170N Oncogenic Gain-of-function 21383740, 25517749 -ALK K1062M Oncogenic Gain-of-function 21383740, 21596819, 18923524 -ALK D1203N Likely Oncogenic Likely Gain-of-function 21948233, 25421750, 25749034 -ALK E1210K Oncogenic Gain-of-function 21383740, 22034911 -ALK T1151R Likely Oncogenic Likely Gain-of-function 25071110, 21383740 -ALK KIF5B-ALK Fusion Likely Oncogenic Gain-of-function 26144315, 21613408 -ALK Fusions Likely Oncogenic Likely Gain-of-function 24060861 -ALK F1174S Oncogenic Gain-of-function 21383740, 23104988 -ALK D1270G Likely Neutral Neutral 21383740, 25517749 -ALK Amplification Likely Oncogenic Likely Gain-of-function 21474455, 24356251, 22614325 -ALK F1245C Oncogenic Gain-of-function 21383740, 25517749, 27049722, 26554404, 22034911, 23598171 -ALK A1200V Likely Neutral Neutral 21383740, 23104988 -ALK L1198F Oncogenic Gain-of-function 21383740, 21596819, 26698910, 25421750 -ALK Y1278S Oncogenic Gain-of-function 25071110, 21383740, 25517749, 27049722, 23598171 -ALK F1174L Oncogenic Gain-of-function 21383740, 25517749, 22072639, 18724359, 21030459, 18923523, 27009859, 21948233, 21596819, 20719933, 18923525, 27049722, 26144315, 26554404, 23104988, 18923524, 26786851, 21242967, 21613408 -ALK R1060H Likely Neutral Neutral 21383740, 23104988 -ALK EML4-ALK Fusion Oncogenic Gain-of-function 21030459, 22235099, 25228534, 21791641, 21948233, 22277784, 18923524, 21613408, 24675041 -ALK V1180L Oncogenic Gain-of-function 25228534, 21383740 -ALK M1166R Oncogenic Gain-of-function 21383740, 25517749, 23104988 -ALK G1123S Oncogenic Gain-of-function 21948233, 21383740 -ALK L1152P Oncogenic Gain-of-function 21383740, 24675041 -ALK T1151M Likely Neutral Likely Neutral 27009859, 21383740, 18923525, 25517749, 23104988 -ALK T1151dup Oncogenic Gain-of-function 22277784, 21383740, 26144315, 24675041 -ALK R1231Q Likely Neutral Neutral 21383740, 23104988 -ALK A1099T Likely Neutral Neutral 21383740, 23104988 -ALK I1171S Oncogenic Gain-of-function 27009859, 21383740, 26464158 -ALK S1206R Oncogenic Gain-of-function 21383740, 22034911 -ALK F1174I Oncogenic Gain-of-function 21383740, 23104988, 25749034 -ALK L1196Q Oncogenic Gain-of-function 23239810 -ALK CAD-ALK Fusion Likely Oncogenic Likely Gain-of-function 26633560 -ALK F1174C Oncogenic Gain-of-function 21383740, 26698910, 22034911, 24675041 -ALK T1087I Likely Neutral Neutral 21383740, 23104988 -SDHB S100F Likely Oncogenic Loss-of-function 17639058, 15987702 -RAD54L G325R Likely Oncogenic Loss-of-function 15056673, 10362365 -SDHC R133* Likely Oncogenic Loss-of-function 24423348 -VEGFA Amplification Likely Oncogenic Gain-of-function 24687604, 21743435, 24114200, 21495021 -MPL S505N Likely Oncogenic Likely Gain-of-function 14764528, 8695859 -MPL W515L Oncogenic Gain-of-function 16834459 -MPL W515K Likely Oncogenic Likely Gain-of-function 16868251, 17709604 -MPL P106L Likely Oncogenic Likely Gain-of-function 25538044, 23351976 -PMS1 Q233* Oncogenic Loss-of-function 8072530 -CARM1 S217E Likely Oncogenic Likely Loss-of-function 19843527 -CARM1 S217C Likely Oncogenic Likely Loss-of-function 19843527 -CARM1 S217T Likely Oncogenic Likely Loss-of-function 19843527 -CARM1 S217A Likely Oncogenic Likely Loss-of-function 19843527 -FOXO1 T24A Likely Oncogenic Likely Loss-of-function 17646672, 16670091 -VHL H115R Likely Oncogenic Loss-of-function 24969085 -VHL L158P Likely Oncogenic Loss-of-function 10535940, 10973499, 19602254 -VHL N90I Likely Oncogenic Loss-of-function 10823831 -VHL S111C Likely Oncogenic Loss-of-function 22071692 -VHL R167Q Oncogenic Loss-of-function 10535940, 24755468, 19030229 -VHL L188Q Likely Oncogenic Loss-of-function 19602254 -VHL L63P Likely Oncogenic Loss-of-function 15611064 -VHL Y98N Likely Oncogenic Likely Loss-of-function 10823831, 10535940 -VHL P25L Likely Neutral Likely Neutral 16884327 -VHL L188V Likely Oncogenic Likely Loss-of-function 10823831 -VHL V84L Inconclusive Inconclusive 10823831 -VHL Truncating Mutations Likely Oncogenic Likely Loss-of-function 21386872, 12050673, 12004076, 22825683 -VHL F119S Likely Oncogenic Likely Loss-of-function 14636579 -VHL S68W Likely Oncogenic Loss-of-function 18544564, 15611064 -VHL Deletion Oncogenic Likely Loss-of-function 21386872, 23632291, 25093046, 19764026 -VHL L158V Likely Oncogenic Loss-of-function 19602254 -VHL L128F Likely Neutral Likely Neutral 11865071 -VHL P86H Likely Oncogenic Loss-of-function 10823831, 10535940 -VHL R167W Oncogenic Loss-of-function 25563310, 14973063, 23824745, 12202531 -VHL V155A Likely Oncogenic Loss-of-function 26503325 -VHL A149P Likely Oncogenic Likely Loss-of-function 14636579 -VHL L118P Likely Oncogenic Likely Loss-of-function 14636579 -VHL R64P Likely Oncogenic Loss-of-function 10823831, 15611064 -VHL I151S Likely Oncogenic Likely Loss-of-function 14636579, 27179072 -VHL N150K Likely Oncogenic Likely Loss-of-function 14636579 -VHL L118R Likely Oncogenic Likely Loss-of-function 14636579 -VHL Y112H Likely Oncogenic Likely Loss-of-function 10823831 -VHL S65L Likely Oncogenic Loss-of-function 15611064 -VHL S65A Likely Oncogenic Likely Loss-of-function 26619011, 15611064 -VHL Q164R Likely Oncogenic Loss-of-function 26503325 -VHL Q96P Likely Oncogenic Loss-of-function 10823831 -VHL W117C Likely Oncogenic Loss-of-function 14636579 -VHL R82P Likely Oncogenic Loss-of-function 10823831 -VHL Q145H Likely Neutral Loss-of-function 15611064 -VHL N78S Likely Oncogenic Loss-of-function 19602254 -VHL D121G Likely Oncogenic Likely Loss-of-function 26619011, 11865071 -VHL L158Q Likely Oncogenic Loss-of-function 2706960 -VHL E70K Likely Oncogenic Likely Loss-of-function 15611064 -VHL R69C Likely Oncogenic Loss-of-function 15611064 -VHL G114R Likely Oncogenic Likely Loss-of-function 14636579, 27179072 -VHL H191D Oncogenic Loss-of-function 21685897 -VHL S65W Likely Oncogenic Loss-of-function 15611064 -VHL H115Q Likely Oncogenic Likely Loss-of-function 24969085, 12202531 -VHL Y98H Likely Oncogenic Likely Loss-of-function 10823831 -VHL R200W Oncogenic Loss-of-function 21685897 -MAP2K4 R304* Likely Oncogenic Loss-of-function 21896780 -MAP2K4 R134Q Likely Oncogenic Likely Gain-of-function 21896780, 26619011 -MAP2K4 N234I Oncogenic Loss-of-function 20668451, 15122334 -MAP2K4 R154W Oncogenic Loss-of-function 20668451, 15122334 -MAP2K4 S251N Oncogenic Loss-of-function 20668451, 15122334 -MAP2K4 Truncating Mutations Likely Oncogenic Likely Loss-of-function 21896780 -MAP2K4 R228K Oncogenic Loss-of-function 20668451, 15122334 -MAP2K4 A279T Oncogenic Loss-of-function 21896780, 20668451, 15122334 -MAP2K4 V321M Likely Oncogenic Loss-of-function 21896780 -MAP2K4 P326L Likely Oncogenic Loss-of-function 21896780 -MAP2K4 G85R Oncogenic Loss-of-function 20668451, 15122334 -RRAS2 Q72L Oncogenic Gain-of-function 8052619 -FLT1 Amplification Inconclusive Inconclusive Zehir A et al. Nature Medicine, 2017 http://doi:10.1038/nm.4333 -FLT3 D835Y Oncogenic Gain-of-function 11290608, 23631653, 15256420, 26108694, 24255108 -FLT3 V592G Oncogenic Gain-of-function 18068628 -FLT3 D835V Oncogenic Gain-of-function 11290608, 15256420, 26108694 -FLT3 Y599_D600insPAPQIMSTSTLISENMNIA Oncogenic Gain-of-function 9737679, 11090077, 23631653 -FLT3 K602_W603insYEYDLK Oncogenic Gain-of-function 9737679, 11090077, 23631653 -FLT3 E598_Y599insGLVQVTGSSDNEYFYVDFREYE Oncogenic Gain-of-function 9737679, 11090077, 23631653, 11756186 -FLT3 F594L Oncogenic Gain-of-function 16410449 -FLT3 M664I Likely Oncogenic Likely Gain-of-function 25847190 -FLT3 I867S Oncogenic Gain-of-function 24608088 -FLT3 Y599F Likely Neutral Likely Loss-of-function 16684964 -FLT3 W603_E604insDREYEYDLKW Oncogenic Gain-of-function 9737679, 11090077, 23631653 -FLT3 E612_F613insGYVDFREYEYDLKWEFRPRENLEF Oncogenic Gain-of-function 9737679, 11090077, 23631653, 11756186 -FLT3 D835E Oncogenic Gain-of-function 11290608, 15256420, 26108694 -FLT3 V194M Likely Neutral Neutral 18068628 -FLT3 D324N Likely Neutral Neutral 18068628 -FLT3 E598_Y599insDVDFREYE Oncogenic Gain-of-function 9737679, 11090077, 23631653 -FLT3 A627T Likely Oncogenic Likely Gain-of-function 15374944 -FLT3 I836del Likely Oncogenic Gain-of-function 23878140 -FLT3 D835H Oncogenic Gain-of-function 11290608, 15256420, 26108694 -FLT3 F594_R595insSDNEYFYVDF Oncogenic Gain-of-function 9737679, 11090077, 23631653 -FLT3 S451F Oncogenic Gain-of-function 18068628 -FLT3 Y591D Oncogenic Gain-of-function 16410449 -FLT3 V592A Oncogenic Gain-of-function 16410449 -FLT3 N676K Oncogenic Gain-of-function 23878140 -FLT3 L601_K602insREYEYDL Oncogenic Gain-of-function 9737679, 11090077, 23631653, 11756186 -FLT3 T167A Likely Neutral Neutral 18068628 -FLT3 S840_N841insGS Oncogenic Gain-of-function 9737679, 11090077, 23631653, 12384447 -FLT3 D835del Oncogenic Gain-of-function 15256420 -FLT3 Y364H Likely Neutral Neutral 18068628 -FLT3 K868N Likely Neutral Loss-of-function 27272783 -FLT3 N841I Oncogenic Gain-of-function 15178581 -FLT3 Y572C Oncogenic Gain-of-function 18068628 -FLT3 V557I Likely Neutral Neutral 18068628 -FLT3 D835N Oncogenic Gain-of-function 11290608, 15256420, 26108694 -FLT3 F590G Oncogenic Gain-of-function 16410449 -FLT3 D839G Oncogenic Gain-of-function 24608088 -FLT3 Y599_D600insSTDNEYFYVDFREYEY Oncogenic Gain-of-function 9737679, 11090077, 23631653 -FLT3 N676S Likely Oncogenic Likely Gain-of-function 25847190 -FLT3 V579A Oncogenic Gain-of-function 16410449 -FLT3 D600_L601insDFREYEYD Oncogenic Gain-of-function 9737679, 11090077, 23631653 -FLT3 Y599_D600insEYEYEYEY Oncogenic Gain-of-function 9737679, 11090077, 23631653 -FLT3 D835A Oncogenic Gain-of-function 11290608, 15256420, 26108694 -FLT3 L611_E612insCSSDNEYFYVDFREYEYDLKWEFPRENL Oncogenic Gain-of-function 9737679, 11090077, 23631653, 11756186 -FLT3 R834Q Oncogenic Gain-of-function 18068628 -FLT3 Amplification Likely Oncogenic Gain-of-function 25848357, 27906677 -FLT3 FLT3 internal tandem duplications Oncogenic Gain-of-function 23631653 -FLT3 N676D Likely Oncogenic Likely Gain-of-function 22875611 -FLT3 S451E Oncogenic Gain-of-function 18068628 -FLT3 F691L Oncogenic Gain-of-function 19318574, 23430109 -FLT3 Y842C Oncogenic Gain-of-function 15345593 -FLT3 G831E Likely Neutral Neutral 18068628 -FLT3 M737I Likely Neutral Neutral 18068628 -FLT3 Y599_D600insGLYVDFREYEY Oncogenic Gain-of-function 9737679, 11090077, 23631653, 11756186 -FLT3 D600_L601insFREYEYD Oncogenic Gain-of-function 9737679, 11090077, 23631653 -PMS2 G207E Likely Oncogenic Likely Loss-of-function 19479271, 24027009 -PMS2 T485K Likely Neutral Likely Neutral 15256438, 24362816, 24027009 -PMS2 Truncating Mutations Likely Oncogenic Likely Loss-of-function 12697830, 20487569, 23582141, 21376568, 7892206, 16144131, 9488480 -PMS2 R20Q Oncogenic Loss-of-function 25512458 -PMS2 G857A Likely Neutral Likely Neutral 24362816, 24027009 -PMS2 L585I Likely Neutral Likely Neutral 24362816, 24027009 -PMS2 R802* Likely Oncogenic Likely Loss-of-function 24362816, 16507833 -PMS2 R421* Likely Oncogenic Likely Loss-of-function 24362816 -PMS2 I668V Oncogenic Loss-of-function 25691505 -PMS2 E541K Likely Neutral Likely Neutral 24362816, 24027009 -PMS2 E41A Oncogenic Loss-of-function 20864418, 24027009 -PMS2 R315* Likely Oncogenic Likely Loss-of-function 24362816 -PMS2 S46I Oncogenic Loss-of-function 18602922, 25883011, 23709753, 17557300, 24027009, 2257789, 18709565, 16144131 -PMS2 P470S Likely Neutral Likely Neutral 24362816, 24027009 -PMS2 S46N Oncogenic Loss-of-function 24027009 -PMS2 Deletion Likely Oncogenic Likely Loss-of-function 18602922, 23837913, 16472587 -PMS2 E5K Likely Neutral Likely Neutral 24362816 -PMS2 I18V Likely Neutral Neutral 24362816, 24027009 -SRSF2 P95H Oncogenic Loss-of-function 27135740, 25965569, 26124281, 26261309 -WHSC1 E1099K Oncogenic Gain-of-function 23823660, 24076604 -PPM1D 422_605trunc Likely Oncogenic Gain-of-function 25742468, 24880341, 23907125 -POLD1 Truncating Mutations Likely Oncogenic Likely Loss-of-function -POLE L424V Likely Oncogenic Loss-of-function 23263490, 25228659 -POLE P286H Likely Oncogenic Loss-of-function 25228659 -POLE S459F Likely Oncogenic Loss-of-function 25228659 -POLE S279Y Likely Oncogenic Likely Loss-of-function 25228659, 24472300 -POLE F367S Likely Oncogenic Loss-of-function 21157497, 25228659 -POLE P286S Likely Oncogenic Loss-of-function 25228659 -POLE L424I Likely Oncogenic Loss-of-function 25228659 -POLE V411L Likely Oncogenic Loss-of-function 25228659, 23636398 -POLE S297F Likely Oncogenic Likely Loss-of-function 25228659, 24472300 -POLE S459del Likely Oncogenic Likely Loss-of-function 25228659 -POLE P286R Likely Oncogenic Loss-of-function 25228659, 23636398 -KNSTRN R11K Likely Oncogenic Likely Loss-of-function 25194279 -KNSTRN S24F Oncogenic Loss-of-function 25194279 -KNSTRN P26S Likely Oncogenic Likely Loss-of-function 25194279 -KNSTRN A40E Likely Oncogenic Likely Loss-of-function 25194279 -KNSTRN P28S Likely Oncogenic Likely Loss-of-function 25194279 -PIK3R3 Truncating Mutations Likely Oncogenic Likely Loss-of-function 25424831, 27766312 -APC Truncating Mutations Likely Oncogenic Likely Loss-of-function 11062151, 15561772, 11257105 -APC R640G Oncogenic Loss-of-function 19111562 -APC Deletion Likely Oncogenic Likely Loss-of-function 8259511, 15643602, 25317407, 11867715 -APC N1026S Likely Oncogenic Loss-of-function 18166348 -APC I1307K Likely Oncogenic Likely Loss-of-function 9724771 -APC A290T Likely Oncogenic Likely Loss-of-function 11606402 -RICTOR Amplification Oncogenic Gain-of-function 19934294, 20978191, 26370156, 19185849 -MSH2 Deletion Likely Oncogenic Likely Loss-of-function 9823339, 21970482, 22781090, 23264089, 17250661 -MSH2 Q395* Oncogenic Loss-of-function 24362816 -MSH2 G322D Likely Neutral Likely Neutral 24362816 -MSH2 R389* Oncogenic Loss-of-function 19459153, 26864202, 25430799 -MSH2 Q337* Oncogenic Loss-of-function 24362816 -MSH2 A636P Likely Oncogenic Likely Loss-of-function 12595050, 10528862 -MSH2 R711* Oncogenic Loss-of-function 24362816 -MSH2 R680* Oncogenic Loss-of-function 24362816 -MSH2 L390F Likely Neutral Likely Neutral 24362816 -MSH2 A272V Likely Neutral Likely Neutral 17101317, 21120944 -MSH2 D603N Oncogenic Loss-of-function 21120944, 18951462 -MSH2 S860L Likely Neutral Likely Neutral 24362816, 22102614 -MSH2 S723F Likely Oncogenic Likely Loss-of-function 24362816, 22102614, 26951660 -MSH2 G751R Likely Oncogenic Loss-of-function 24362816, 10732761, 17720936 -MSH2 Truncating Mutations Likely Oncogenic Likely Loss-of-function 11257106, 23391514, 15528792, 10946232 -MSH2 Q429* Oncogenic Loss-of-function 7726159 -MSH2 E580* Oncogenic Loss-of-function 24362816 -MSH2 R383* Oncogenic Loss-of-function 8592341 -MSH2 D603G Inconclusive Inconclusive 24362816 -MSH2 R621* Oncogenic Loss-of-function 8566964 -MSH2 W345* Oncogenic Loss-of-function 24362816 -MSH2 Q816* Oncogenic Loss-of-function 24362816 -MSH2 E483* Oncogenic Loss-of-function 24362816 -IDH1 R132G Oncogenic Switch-of-function 23264629, 23630074, 19935646 -IDH1 G97D Likely Oncogenic Switch-of-function 21996744 -IDH1 E190K Likely Neutral Likely Neutral 27147599 -IDH1 G70D Likely Neutral Loss-of-function 21996744 -IDH1 H133Q Likely Neutral Likely Neutral 21996744 -IDH1 A134D Likely Neutral Loss-of-function 21996744 -IDH1 R132H Oncogenic Switch-of-function 25730874, 23393090, 22763442, 22343901, 23630074, 22343889, 22899282, 19935646 -IDH1 I99M Likely Neutral Likely Neutral 21996744 -IDH1 P33S Likely Neutral Likely Neutral 27147599 -IDH1 Y139D Likely Oncogenic Gain-of-function 21996744 -IDH1 R132S Likely Oncogenic Switch-of-function 21760534, 25257301, 23630074, 21912393, 22033490, 19935646 -IDH1 R49C Likely Neutral Loss-of-function 21996744 -IDH1 R132C Oncogenic Switch-of-function 23630074, 23954893, 19935646 -IDH1 V294M Likely Neutral Likely Neutral 21996744 -IDH1 G123R Likely Neutral Loss-of-function 20171178 -IDH1 R100A Likely Oncogenic Switch-of-function 21996744 -IDH1 I130M Likely Neutral Likely Neutral 21996744 -IDH1 R132Q Likely Oncogenic Likely Switch-of-function 25730874, 23630074, 19935646 -IDH2 R172M Likely Oncogenic Likely Switch-of-function 27147599, 20171147 -IDH2 R172K Oncogenic Switch-of-function 20171147, 25043045 -IDH2 R172G Likely Oncogenic Likely Switch-of-function 21641335, 20171147 -IDH2 R140Q Oncogenic Switch-of-function 20692206, 23264629, 20171147, 25043045, 24440599, 20847235 -IDH2 R172S Oncogenic Switch-of-function 23264629, 20171147 -XPO1 E571K Likely Oncogenic Likely Gain-of-function 21741593, 21642962, 27312795, 26619011, 27479820 -XPO1 C528S Inconclusive Inconclusive 27680702, 23034282 -XRCC2 Deletion Likely Neutral Likely Loss-of-function 22464251, 14678973, 10517641 -XRCC2 R188H Likely Oncogenic Likely Loss-of-function 12023985 -XRCC2 Truncating Mutations Likely Oncogenic Likely Loss-of-function 22464251, 14678973, 10517641 -CREBBP W1502A Likely Oncogenic Loss-of-function 11691934, 21390130 -CREBBP Deletion Likely Oncogenic Likely Loss-of-function 21390130 -CREBBP R1563S Likely Neutral Likely Neutral 21390130 -CREBBP Truncating Mutations Likely Oncogenic Likely Loss-of-function 21390130 -CREBBP R1446C Likely Oncogenic Likely Loss-of-function 21390130 -CREBBP Q1500P Likely Neutral Likely Neutral 21390130 -CREBBP R1446H Likely Oncogenic Likely Loss-of-function 21390130 -DIS3 R780K Oncogenic Loss-of-function 26193331, 24150935 -AR F877L Oncogenic Gain-of-function 23779130, 23842682, 23580326 -AR G248V Inconclusive Inconclusive 25500996 -AR L57Q Likely Neutral Loss-of-function 22403669 -AR G216R Inconclusive Inconclusive 25500996 -AR W742C Oncogenic Gain-of-function 12517791 -AR T878A Oncogenic Gain-of-function 9092797, 2260966, 10363963, 9815822, 25320358 -AR A159T Likely Neutral Likely Loss-of-function 25500996 -AR T878S Oncogenic Gain-of-function 9092797, 2260966, 9815822 -AR Q58_Q59insL Likely Neutral Likely Loss-of-function 25500996 -AR P380R Inconclusive Inconclusive 25500996 -AR Amplification Oncogenic Gain-of-function 7795646, 7511045, 11306464, 12888829, 14702632, 10496349 -AR F876L Likely Oncogenic Likely Gain-of-function 23779130, 2384268 -AR Q58L Inconclusive Inconclusive 12801573, 23637914, 24737579 -AR AR-V7 Oncogenic Gain-of-function 20823238, 19117982, 24449822, 22014572, 23851510, 21552559, 19244107, 20644256 -AR L702H Oncogenic Gain-of-function 11956172, 10835690 -AR W742L Oncogenic Gain-of-function 12517791 -AR H875Y Oncogenic Gain-of-function 9092797, 9815822 -AR L272F Likely Neutral Likely Neutral 25500996 -AR N235K Likely Neutral Likely Loss-of-function 25500996, 11422119 -AR ARv567es Oncogenic Gain-of-function 20823238, 19117982, 24449822, 22014572, 23851510, 21552559, 19244107, 20644256 -AR L57del Likely Neutral Likely Neutral 25500996 -AR Q120E Likely Neutral Likely Neutral 25500996 -ARAF S214F Oncogenic Gain-of-function 24569458, 15520807 -ARAF F351L Oncogenic Gain-of-function 24652991 -ARAF S214C Oncogenic Gain-of-function 24569458, 15520807 -ARAF G322S Likely Oncogenic Gain-of-function 25608663, 24569458 -ARAF S214A Likely Oncogenic Likely Gain-of-function 24569458, 26566875, 15520807 -ARAF Q347_A348del Oncogenic Gain-of-function 24652991 -ARAF S214T Likely Oncogenic Gain-of-function 24569458, 15520807 -ARAF N217I Oncogenic Gain-of-function 25608663, 15520807 -RHOA G17V Oncogenic Loss-of-function 24413737, 24584070 -RHOA E40L Likely Oncogenic Likely Gain-of-function 26619011, 9482732 -RHOA T37A Likely Oncogenic Likely Gain-of-function 19147561, 15993039 -RHOA G17E Likely Oncogenic Likely Loss-of-function 24816255 -RHOA Amplification Oncogenic Gain-of-function 10213513, 15448013, 25104222 -RHOA Overexpression Oncogenic Gain-of-function 10213513, 15448013, 25104222 -RHOA E40Q Likely Oncogenic Likely Gain-of-function 26619011, 9565577 -RHOA Y34F Likely Oncogenic Likely Switch-of-function 24398689, 26619011 -RHOA E40T Likely Oncogenic Likely Gain-of-function 26619011, 9482732 -RHOA Y34C Likely Oncogenic Likely Gain-of-function 26619011, 9565577 -RHOA L57V Oncogenic Loss-of-function 24816253 -RHOA Y42C Oncogenic Loss-of-function 9482732, 24816253, 24816255 -RHOA E40W Likely Oncogenic Likely Loss-of-function 26619011, 9482732 -RHOA G17A Likely Oncogenic Loss-of-function 22491204, 12221096, 16472675 -RHOA G14V Likely Neutral Loss-of-function 24584070, 19515453 -RHOA E40N Likely Oncogenic Likely Switch-of-function 26619011, 9482732 -RHOA T19N Likely Oncogenic Loss-of-function 19147561, 24584070 -RHOA R5Q Likely Oncogenic Likely Loss-of-function 25044415 -NCOR1 Truncating Mutations Likely Oncogenic Likely Loss-of-function 21102521, 7566114 -PPP2R1A R183P Likely Oncogenic Likely Loss-of-function 17174897, 17086192, 18922469 -PPP2R1A S256F Likely Oncogenic Likely Loss-of-function 21435433, 17174897, 17086192, 18922469 -PPP2R1A W257C Likely Oncogenic Likely Loss-of-function 21435433, 17174897, 17086192, 18922469 -PPP2R1A R183Q Likely Oncogenic Likely Loss-of-function 17174897, 17086192, 18922469 -PPP2R1A P179L Likely Oncogenic Likely Loss-of-function 17174897, 17086192, 18922469 -PPP2R1A S256W Likely Oncogenic Likely Loss-of-function 21435433, 17174897, 17086192, 18922469 -PPP2R1A R183W Likely Oncogenic Likely Loss-of-function 17174897, 17086192, 18922469 -PPP2R1A S256Y Likely Oncogenic Likely Loss-of-function 21435433, 17174897, 17086192, 18922469 -PPP2R1A W257G Likely Oncogenic Gain-of-function 21435433, 17174897, 17086192, 18922469, 27272709 -PPP2R1A R258C Inconclusive Inconclusive 17174897, 17086192, 18922469 -PPP2R1A R182W Likely Oncogenic Likely Loss-of-function 21435433, 17174897, 17086192, 18922469, 26168268 -PPP2R1A R258H Inconclusive Inconclusive 17174897, 17086192, 18922469 -PPP2R1A P179R Likely Oncogenic Likely Loss-of-function 17174897, 17086192, 18922469 -PPP2R1A R183G Likely Oncogenic Likely Loss-of-function 17174897, 17086192, 18922469 -SETD2 Deletion Oncogenic Loss-of-function 27282254 McKinney et al. Abstract #1052, ASH 2016 https://ash.confex.com/ash/2016/webprogram/Paper96954.html -SETD2 R1625C Oncogenic Loss-of-function 27528607 -SETD2 Truncating Mutations Likely Oncogenic Likely Loss-of-function 24509477, 25728682, 23417712 -IGF1R G119T Likely Oncogenic Loss-of-function 23045302 -IGF1R G1125A Likely Neutral Likely Loss-of-function 20103656 -IGF1R M1255I Likely Oncogenic Likely Gain-of-function 22778948 -IGF1R A1374V Likely Oncogenic Likely Gain-of-function 22778948 -PPP6C R264C Likely Oncogenic Loss-of-function 23729733 -PPP6C P186S Likely Oncogenic Loss-of-function 23729733 -PPP6C H114Y Oncogenic Loss-of-function 23729733 -PPP6C S270L Likely Oncogenic Loss-of-function 23729733 -CTCF H284Y Likely Oncogenic Likely Loss-of-function 11782357, 24794443, 26619011 -CTCF H284N Likely Oncogenic Likely Loss-of-function 11782357, 24794443, 26619011 -CTCF H284P Likely Oncogenic Likely Loss-of-function 11782357, 24794443, 26619011 -CTCF Deletion Likely Oncogenic Likely Loss-of-function 26330387, 24130125, 19568526 -CTCF Truncating Mutations Likely Oncogenic Likely Loss-of-function 25079317, 24130125, 23636398 -CTCF R339W Likely Oncogenic Switch-of-function 11782357 -IKBKE Amplification Likely Oncogenic Likely Gain-of-function 17574021, 25365225 -MTOR L2431P Oncogenic Gain-of-function 22397650 -MTOR R2505P Oncogenic Gain-of-function 20190810, 24631838, 26255626 -MTOR P2476L Likely Neutral Neutral 20190810 -MTOR E2288K Likely Oncogenic Gain-of-function 23322780 -MTOR T1977K Oncogenic Gain-of-function 27482884 -MTOR A1459P Likely Oncogenic Gain-of-function 24631838 -MTOR T1977R Oncogenic Gain-of-function 24631838 -MTOR R2505Q Likely Neutral Neutral 24631838 -MTOR E2419K Oncogenic Gain-of-function 24625776 -MTOR C1483Y Oncogenic Gain-of-function 24631838 -MTOR A41S Likely Neutral Neutral 24631838 -MTOR T1977S Likely Neutral Neutral 24631838 -MTOR L2230V Oncogenic Gain-of-function 27482884 -MTOR L2427R Likely Oncogenic Gain-of-function 27713405 -MTOR S2215F Oncogenic Gain-of-function 24631838 -MTOR D2512H Likely Oncogenic Likely Gain-of-function 24631838 -MTOR A41T Likely Neutral Neutral 24631838 -MTOR A8S Likely Neutral Likely Neutral 20190810 -MTOR M2327I Likely Oncogenic Gain-of-function 27279227 -MTOR F1888L Oncogenic Gain-of-function 24631838 -MTOR R2430M Likely Neutral Neutral 24631838 -MTOR F1888I Likely Oncogenic Gain-of-function 24631838 -MTOR E2014K Likely Oncogenic Gain-of-function 24625776 -MTOR E1799K Oncogenic Gain-of-function 24631838 -MTOR F1888V Likely Neutral Neutral 24631838 -MTOR Y1463S Likely Oncogenic Likely Gain-of-function 24631838, 26255626 -MTOR V2006L Likely Oncogenic Likely Gain-of-function 24631838, 26619011 -MTOR A1519T Oncogenic Gain-of-function 24631838, 26255626 -MTOR D2512Y Likely Neutral Neutral 24631838 -MTOR K1452N Likely Oncogenic Likely Gain-of-function 24631838, 26255626 -MTOR Q2223K Oncogenic Gain-of-function 24622468 -MTOR S2215T Likely Neutral Neutral 24631838 -MTOR L1460P Oncogenic Gain-of-function 20190810, 24631838, 26255626 -MTOR C1483R Likely Oncogenic Gain-of-function 24631838 -MTOR W1456R Likely Oncogenic Likely Gain-of-function 23322780, 22460905 -MTOR P2273S Likely Oncogenic Gain-of-function 23322780 -MTOR R2152C Likely Neutral Neutral 24631838 -MTOR C1483W Likely Oncogenic Gain-of-function 24631838 -MTOR I2500F Oncogenic Gain-of-function 24631838 -MTOR A2034V Likely Oncogenic Likely Gain-of-function 27279227 -MTOR A41P Likely Neutral Neutral 24631838 -MTOR I2500M Oncogenic Gain-of-function 24631838 -MTOR V2006I Likely Oncogenic Gain-of-function 24631838 -MTOR S2215Y Oncogenic Gain-of-function 20190810, 24631838, 24336570 -MTOR L1433S Oncogenic Gain-of-function 24631838, 26255626 -MTOR R2505* Likely Neutral Neutral 24631838 -MTOR F2108L Likely Oncogenic Likely Gain-of-function 27279227 -MTOR C1483F Oncogenic Gain-of-function 24631838, 26255626 -MTOR D2512G Likely Neutral Neutral 24631838 -MTOR T1977I Likely Oncogenic Gain-of-function 26432419 -TET1 Truncating Mutations Likely Oncogenic Likely Loss-of-function 21057493, 22156206, 19372391 -TET1 MLL-TET1 Fusion Oncogenic Gain-of-function 19144982, 12646957, 23818607, 24323992 -TET1 Deletion Likely Oncogenic Likely Loss-of-function 21625234, 19420352, 25867473 -SMARCA4 Truncating Mutations Likely Oncogenic Likely Loss-of-function 24658002, 24658001, 24658004, 25060813, 18301784 -SMARCA4 T910M Likely Oncogenic Loss-of-function 26842758, 23698369 -SMARCA4 R1189* Likely Oncogenic Loss-of-function 20137775 -SMARCA4 R1093* Oncogenic Loss-of-function 24658001, 24658004 -SMARCA4 Deletion Likely Oncogenic Likely Loss-of-function 21520050, 23139211, 18381774, 11481457, 26942101, 11163203 -SMARCA4 R978* Oncogenic Loss-of-function 24658002, 24658004 -SMARCA4 G1232D Likely Oncogenic Loss-of-function 23698369 -SMARCB1 Truncating Mutations Likely Oncogenic Likely Loss-of-function 23620515, 12138206, 9671307, 23435428, 21076395 -SMARCB1 Deletion Likely Oncogenic Likely Loss-of-function 11313485, 10521299, 11095756, 23074045, 9892189, 12450796, 22797305, 11263494 -FOXP1 Truncating Mutations Likely Oncogenic Likely Loss-of-function 25329375 -FOXP1 R514C Likely Oncogenic Likely Loss-of-function 26647308 -SMO Q477E Likely Oncogenic Likely Gain-of-function 25759020, 25759019 -SMO L412F Likely Oncogenic Gain-of-function 2575902, 25759020, 25759019, 25199678 -SMO T241M Likely Oncogenic Gain-of-function 25759019 -SMO I408V Likely Oncogenic Gain-of-function 2575902, 25759020, 25759019, 25199678 -SMO W281C Likely Oncogenic Gain-of-function 25759020, 25759019, 25199678 -SMO V321M Likely Oncogenic Gain-of-function 2575902, 25759020, 25759019, 25199678 -SMO E518K Likely Neutral Likely Neutral 21123452 -SMO L221R Likely Oncogenic Likely Gain-of-function 25759020, 25759019 -SMO S387N Likely Oncogenic Gain-of-function 25759019 -SMO D384N Likely Oncogenic Likely Gain-of-function 25759020, 25759019 -SMO A459V Likely Oncogenic Gain-of-function 25759019 -SMO H231R Likely Oncogenic Likely Gain-of-function 25759020, 25759019 -SMO D473G Likely Oncogenic Likely Gain-of-function 19726788 -SMO F460L Likely Oncogenic Gain-of-function 2575902, 25759020, 25759019, 25199678 -SMO K575M Likely Oncogenic Likely Gain-of-function 16339184, 12499255 -SMO N219D Likely Oncogenic Likely Gain-of-function 25759020, 25759019 -SMO C469Y Likely Oncogenic Gain-of-function 2575902, 25759020, 25759019, 25199678 -SMO E518A Inconclusive Inconclusive 21123452 -SMO W535L Likely Oncogenic Gain-of-function 25759020, 23636324, 9422511 -SMO Amplification Inconclusive Inconclusive 24202394, 26124204, 20215540 Zehir A et al. Nature Medicine, 2017 http://doi:10.1038/nm.4333 -SMO Q635E Likely Oncogenic Likely Gain-of-function 25759020 -SMO V414A Likely Oncogenic Likely Gain-of-function 25801792, 26619011 -SMO D473H Likely Oncogenic Likely Gain-of-function 19726788 -CARD11 C49Y Likely Oncogenic Gain-of-function 25930198, 23149938 -CARD11 S250P Oncogenic Gain-of-function 23027925, 18323416, 26776161 -CARD11 L251P Oncogenic Gain-of-function 23027925, 18323416, 26776161 -CARD11 F123I Likely Oncogenic Gain-of-function 20799731, 23149938 -CARD11 L225LI Likely Oncogenic Gain-of-function 20799731, 23149938 -CARD11 G116S Likely Oncogenic Gain-of-function 23179749 -CARD11 E127G Likely Oncogenic Gain-of-function 23179749 -CARD11 L232LI Likely Oncogenic Likely Gain-of-function 23027925 -CARD11 E93D Oncogenic Gain-of-function 23149938 -CARD11 G123S Likely Oncogenic Likely Gain-of-function 23027925 -CARD11 D387V Likely Oncogenic Likely Gain-of-function 23027925 -CARD11 Amplification Likely Oncogenic Likely Gain-of-function 18323416 Abubaker et al. Abstract# 4192, AACR 2011 http://cancerres.aacrjournals.org/content/71/8_Supplement/4192 -CARD11 E626K Likely Oncogenic Gain-of-function 26551667 -CARD11 D401N Likely Oncogenic Gain-of-function 25921526 -MEF2B K4E Oncogenic Loss-of-function 23974956, 26245647 -MEF2B N81Y Oncogenic Loss-of-function 23974956 -MEF2B E77K Oncogenic Loss-of-function 23974956 -MEF2B Y69H Oncogenic Loss-of-function 23974956 -MEF2B Amplification Likely Oncogenic Likely Gain-of-function 26245647 -MEF2B D83V Oncogenic Gain-of-function 23974956, 26245647 -CTLA4 T17A Likely Oncogenic Likely Loss-of-function 15018649, 11976786, 20064370, 10082437, 8989248, 18528295, 9459504, 12244107 -ATM V2424G Likely Oncogenic Loss-of-function 18634022, 9463314 -ATM Truncating Mutations Likely Oncogenic Likely Loss-of-function 15928302, 16832357, 16998505 -ATM E1978* Likely Oncogenic Likely Loss-of-function 21514219, 18807267 -ATM D2870A Likely Oncogenic Loss-of-function 9733515, 27304073 -ATM Deletion Likely Oncogenic Likely Loss-of-function 21993670, 16014569 -ATM N2875K Likely Oncogenic Loss-of-function 9733515, 27304073 -ATM D1853N Likely Neutral Likely Neutral 20396981, 18264724, 20799949 -NUP93 G591V Likely Neutral Neutral 26878725 -NUP93 Y629C Likely Neutral Neutral 26878725 -NUP93 Exon 13 deletion Likely Oncogenic Likely Loss-of-function 26878725 -NUP93 K442Nfs* Likely Oncogenic Likely Loss-of-function 26878725 -MAPK1 Amplification Likely Oncogenic Gain-of-function 22961667 -MAPK1 E322K Likely Oncogenic Gain-of-function 24390348, 18813840, 25320010, 26551667, 26181029, 15999996, 21098038, 16324895, 16051177 -CTNNB1 S45A Oncogenic Gain-of-function 12799363 -CTNNB1 G34A Likely Oncogenic Gain-of-function 9635572, 15829978, 9065402 -CTNNB1 G34E Likely Oncogenic Gain-of-function 9635572, 10671680, 9065402 -CTNNB1 S33Y Oncogenic Gain-of-function 9635572, 24735922, 18757411, 9065402 -CTNNB1 S37Y Likely Oncogenic Gain-of-function 20606007, 9635572, 9065402 -CTNNB1 S23R Likely Oncogenic Gain-of-function 9635572, 24735922, 18282277, 9065402 Manring et al. Abstract# 2249, AACR 2012 http://cancerres.aacrjournals.org/content/72/8_Supplement/2249 -CTNNB1 D32N Likely Oncogenic Gain-of-function 9635572, 15064718, 9065402 -CTNNB1 S37C Likely Oncogenic Gain-of-function 9635572, 9537226, 9065402 -CTNNB1 S45del Likely Oncogenic Gain-of-function 9635572, 15064718, 9065402 -CTNNB1 S33F Likely Oncogenic Likely Gain-of-function 9635572, 15829978, 27543871, 18757411, 19582367, 9065402 -CTNNB1 P44A Likely Oncogenic Gain-of-function 9635572, 18282277, 9065402 -CTNNB1 S45P Likely Oncogenic Gain-of-function 9635572, 24735922, 18282277, 9065402 Manring et al. Abstract# 2249, AACR 2012 http://cancerres.aacrjournals.org/content/72/8_Supplement/2249 -CTNNB1 S37A Likely Oncogenic Gain-of-function 15579438, 9635572, 9065402 -CTNNB1 H36P Likely Oncogenic Gain-of-function 9635572, 24735922, 18282277, 9065402 Manring et al. Abstract# 2249, AACR 2012 http://cancerres.aacrjournals.org/content/72/8_Supplement/2249 -CTNNB1 D32A Likely Oncogenic Gain-of-function 15829978 -CTNNB1 I35S Likely Oncogenic Gain-of-function 12375019, 9635572, 24735922, 18282277, 9065402, 10665646 Manring et al. Abstract# 2249, AACR 2012 http://cancerres.aacrjournals.org/content/72/8_Supplement/2249 -CTNNB1 D32G Likely Oncogenic Gain-of-function 9635572, 15064718, 9065402 -CTNNB1 S33A Oncogenic Gain-of-function 15829978 -CTNNB1 S45F Likely Oncogenic Gain-of-function 9635572, 18282277, 26686699, 9065402 -CTNNB1 S33C Oncogenic Gain-of-function 9635572, 19582367, 9065402 -CTNNB1 T41A Oncogenic Gain-of-function 9635572, 24735922, 12799363, 9065402 -CTNNB1 K335I Likely Oncogenic Gain-of-function 15579438, 9635572, 24735922, 9065402 -CTNNB1 N387K Likely Oncogenic Gain-of-function 9635572, 24735922, 9065402 -CTNNB1 D32Y Likely Oncogenic Gain-of-function 9635572, 15064718, 9065402 -CTNNB1 W383R Likely Oncogenic Gain-of-function 15579438, 9635572, 9065402 -CTNNB1 S45Y Likely Oncogenic Gain-of-function 9635572, 9065402, 9419974 -CTNNB1 S37F Likely Oncogenic Gain-of-function 9635572, 22815287, 20303878, 9537226, 9065403, 9065402 -CTNNB1 G34V Likely Oncogenic Gain-of-function 9635572, 10671680, 9671767, 9065402 -MAP2K1 F53S Likely Oncogenic Gain-of-function 17981815, 16439621 -MAP2K1 G128V Likely Oncogenic Likely Gain-of-function 24265153 -MAP2K1 L115P Likely Oncogenic Likely Gain-of-function 19915144 -MAP2K1 L37P Likely Oncogenic Likely Gain-of-function 26566875 -MAP2K1 R47Q Oncogenic Gain-of-function 24982505, 22327936 -MAP2K1 D67N Oncogenic Gain-of-function 25351745, 18060073 -MAP2K1 F129L Likely Oncogenic Gain-of-function 21705440, 19915144, 26399658 -MAP2K1 E203K Oncogenic Gain-of-function 25351745, 22197931 -MAP2K1 I103N Likely Oncogenic Gain-of-function 19915144, 12370306 -MAP2K1 P124S Oncogenic Gain-of-function 24265153, 22197931, 25370473 -MAP2K1 N382H Likely Neutral Likely Neutral 22197931 -MAP2K1 P124L Likely Oncogenic Gain-of-function 19915144, 25370473 -MAP2K1 R49L Oncogenic Gain-of-function 22327936 -MAP2K1 K57E Oncogenic Gain-of-function 26566875, 25370473, 24241536 -MAP2K1 K57T Likely Oncogenic Gain-of-function 26644315 -MAP2K1 D65N Likely Neutral Likely Neutral 26566875 -MAP2K1 Q56_V60del Oncogenic Gain-of-function 26324360 -MAP2K1 E102_I103del Likely Oncogenic Gain-of-function 25351745 -MAP2K1 Q56P Oncogenic Gain-of-function 19915144, 25351745, 22327936, 26566875 -MAP2K1 E144K Likely Oncogenic Gain-of-function 26566875 -MAP2K1 Y130C Likely Oncogenic Gain-of-function 18060073, 26566875 -MAP2K1 Amplification Inconclusive Inconclusive 26399658, 26684394 -MAP2K1 H119P Inconclusive Inconclusive 19915144 -MAP2K1 F53L Oncogenic Gain-of-function 25351745, 21383288, 22197931, 26582713, 26324360, 24241536 -MAP2K1 C121S Likely Oncogenic Gain-of-function 24448821, 25351745, 21383288 -MAP2K1 V211D Inconclusive Inconclusive 19915144, 26399658 -MAP2K1 I111A Likely Oncogenic Likely Gain-of-function 12370306 -MAP2K1 Q58_E62del Likely Oncogenic Gain-of-function 26566875 -MAP2K1 V60M Likely Oncogenic Gain-of-function 26566875 -MAP2K1 F53C Likely Oncogenic Likely Gain-of-function 17981815 -MAP2K1 I111N Inconclusive Inconclusive 19915144 -MAP2K1 I111R Likely Oncogenic Likely Gain-of-function 12370306 -MAP2K1 L115R Inconclusive Inconclusive 19915144 -MAP2K1 S218D Likely Oncogenic Gain-of-function 17981815, 16439621 -MAP2K1 S222D Oncogenic Gain-of-function 17981815, 16439621 -MAP2K1 P306H Likely Oncogenic Gain-of-function 22327936 -MAP2K1 I204T Likely Oncogenic Gain-of-function 22327936 -MAP2K1 K59del Likely Oncogenic Gain-of-function 22389471 -MAP2K1 I111P Likely Oncogenic Likely Gain-of-function 12370306 -MAP2K1 P387S Likely Neutral Likely Neutral 22389471 -MAP2K1 K57N Oncogenic Gain-of-function 25351745, 18632602, 26566875 -MAP2K1 P124Q Likely Oncogenic Gain-of-function 25370473 -MAP2K1 V60E Likely Oncogenic Likely Gain-of-function 24265153 -MAP2K1 E120Q Likely Neutral Likely Neutral 26566875 -MAP2K1 S123T Likely Oncogenic Gain-of-function 26566875 -MAP2K1 K97M Likely Neutral Loss-of-function 22177953, 10567369, 16439621 -MAP2K1 T28I Likely Oncogenic Likely Gain-of-function 26566875 -MAP2K2 Q60P Oncogenic Gain-of-function 24265154, 24055054 -MAP2K2 C125S Oncogenic Gain-of-function 24265153, 21383288 -MAP2K2 F57V Likely Oncogenic Likely Gain-of-function 18042262, 18456719, 16439621 -MAP2K2 K101M Inconclusive Inconclusive 19376813, 22177953, 16439621 -MAP2K2 V35M Oncogenic Gain-of-function 24265153, 21383288 -MAP2K2 S226D Inconclusive Inconclusive 16439621 -MAP2K2 E207K Oncogenic Gain-of-function 22197931 -MAP2K2 S222D Inconclusive Inconclusive 16439621 -MAP2K2 F57C Likely Oncogenic Gain-of-function 16439621 -MAP2K2 F57L Likely Oncogenic Likely Gain-of-function 18042262, 18456719, 16439621 -MAP2K2 N126D Oncogenic Gain-of-function 25487361, 24265153 -MAP2K2 L46F Oncogenic Gain-of-function 24265153, 21383288 -SPEN Truncating Mutations Likely Oncogenic Likely Loss-of-function 26297734 -STAG2 Truncating Mutations Likely Oncogenic Likely Loss-of-function 22417201, 21852505, 24121789, 25010205 -IL7R T244_I245insCPT Oncogenic Gain-of-function 21892159 -SOS1 R552G Likely Oncogenic Gain-of-function 17143285 -SOS1 E846K Likely Oncogenic Gain-of-function 21041952, 17143285 -SOS1 R552S Likely Oncogenic Gain-of-function 27304678 -SOS1 M269R Likely Oncogenic Gain-of-function 27304678, 17143285, 25712082, 24297905 -SOS1 G434R Likely Oncogenic Likely Gain-of-function 27304678 -SOS1 N233Y Likely Oncogenic Gain-of-function 27304678 -MYC T73A Likely Oncogenic Gain-of-function 10378696, 20399964, 21266350, 18642118, 16934487, 19029958, 10706881, 22464321 -MYC IGH-MYC Fusion Oncogenic Gain-of-function 10378696, 22333947, 16934487, 19029958, 22464321 -MYC T73I Likely Oncogenic Likely Gain-of-function 20713710, 26619011, 10825194 -MYC MYC-nick Inconclusive Inconclusive 24696454, 20691906 -MYC IGK-MYC Fusion Oncogenic Gain-of-function 19351371, 10378696, 24957271, 7731690, 8502472, 22333947, 16934487, 21887927, 19029958, 8816814, 19246886, 22464321 -MYC PVT1-MYC Fusion Likely Oncogenic Likely Gain-of-function 22134537, 24298051 -MYC Amplification Oncogenic Gain-of-function 20164920, 10378696, 16934487, 15083194, 19029958, 22464321 -MYC Fusions Likely Oncogenic Likely Gain-of-function 22333947, 16934487 -MYC IGL-MYC Fusion Oncogenic Gain-of-function 10378696, 11034608, 7731690, 8502472, 22333947, 16934487, 19029958, 8816814, 22464321 -MYCN Amplification Oncogenic Gain-of-function 12612655, 16116477, 22035742, 22139329, 23091029, 21533284, 15013217, 9214616 -MYCN P44L Likely Oncogenic Likely Gain-of-function 23334666, 24086065 -SOX9 Deletion Likely Oncogenic Likely Loss-of-function 10446171, 12783851, 9002675 -SOX9 H65Y Likely Oncogenic Loss-of-function 10446171 -SOX9 A19V Likely Neutral Neutral 10446171 -SOX9 Truncating Mutations Likely Oncogenic Likely Loss-of-function 10446171, 27248473 -SOX9 L142P Likely Oncogenic Loss-of-function 27429045 -SOX9 P70R Likely Oncogenic Likely Loss-of-function 10446171 -SOX9 F12L Likely Oncogenic Loss-of-function 10446171 -SOX9 K398A Likely Oncogenic Gain-of-function 15694126 -TET2 W1291R Likely Oncogenic Likely Loss-of-function 24315485 -TET2 D1384V Inconclusive Inconclusive 24315485 -TET2 Y1295A Likely Neutral Likely Neutral 24315485 -TET2 R1262A Likely Neutral Likely Neutral 24315485 -TET2 Y1294A Inconclusive Inconclusive 24315485 -TET2 Y1902A Likely Oncogenic Likely Loss-of-function 24315485 -TET2 N1387A Likely Oncogenic Likely Loss-of-function 24315485 -TET2 M1293A Inconclusive Inconclusive 24315485 -TET2 Truncating Mutations Likely Oncogenic Likely Loss-of-function 21057493, 24315485 -TET2 R1896M Likely Oncogenic Likely Loss-of-function 24315485 -TET2 S1290A Likely Neutral Likely Neutral 24315485 -TET2 K1299E Inconclusive Inconclusive 24315485 -TET2 H1382Y Inconclusive Inconclusive 24315485 -TET2 Deletion Likely Oncogenic Loss-of-function 21625234, 25224413, 21723200, 22017486 -TET2 S1303N Inconclusive Inconclusive 24315485 -TET2 H1904R Likely Oncogenic Likely Loss-of-function 24315485 -MYD88 L265P Oncogenic Gain-of-function 25723115, 26111727 -MYD88 M232T Oncogenic Gain-of-function 25359991 -MYD88 S243N Oncogenic Gain-of-function 24534189, 2179087 -AGO2 R583A Likely Oncogenic Likely Loss-of-function 17891150 -AGO2 Amplification Likely Oncogenic Likely Gain-of-function 18787018, 23775134 -AGO2 A603fs Likely Oncogenic Likely Loss-of-function 20198652, 14749716 -AGO2 R647A Likely Oncogenic Likely Loss-of-function 17891150 -AGO2 Q545A Likely Oncogenic Likely Loss-of-function 17891150 -AGO2 R812A Likely Oncogenic Likely Loss-of-function 17891150 -KMT2B Truncating Mutations Inconclusive Inconclusive 25998713, 16540515, 17429066 -ATR Truncating Mutations Likely Oncogenic Likely Loss-of-function 10691732, 15282542 -ATRX Truncating Mutations Likely Oncogenic Likely Loss-of-function 21719641, 8968741, 24148618, 15591283, 14592816, 18409179, 17609377 -ATRX Deletion Likely Oncogenic Likely Loss-of-function 21719641, 27311324, 24148618, 26741321, 23904111 -CDK12 R882L Likely Oncogenic Loss-of-function 24554720, 21720365, 25712099 -CDK12 Amplification Inconclusive Inconclusive 20932292, 26658019, 21097718 -CDK12 K765R Likely Oncogenic Likely Loss-of-function 24554720, 25712099 -CDK12 Truncating Mutations Likely Oncogenic Likely Loss-of-function 24554720, 21720365, 25712099, 26787825 -CDK12 W719* Likely Oncogenic Loss-of-function 24554720, 25712099 -CDK12 L996F Likely Oncogenic Loss-of-function 24554720, 21720365, 25712099 -CDK12 Deletion Likely Oncogenic Likely Loss-of-function 24554720, 25712099, 24240700 -CDK12 Y901C Likely Oncogenic Loss-of-function 24554720, 21720365, 25712099 -CDK12 G909R Likely Oncogenic Loss-of-function 24554720, 25712099 -CDK12 D887N Likely Oncogenic Likely Loss-of-function 24554720 -CDK12 K975E Likely Neutral Likely Neutral 24554720, 21720365, 25712099 -AXL Amplification Likely Oncogenic Likely Gain-of-function 23264849, 22751098, 25337673, 25966280 -MYOD1 L122R Oncogenic Likely Gain-of-function 24793135, 1329087 -B2M M1R Likely Oncogenic Loss-of-function 22137796 -B2M M1V Likely Oncogenic Loss-of-function 24947018 -B2M M1T Likely Oncogenic Loss-of-function 22137796 -B2M Deletion Likely Oncogenic Likely Loss-of-function 25594174, 25294904, 22833104, 16730261, 22137796, 23784959, 9637706, 1898655 -B2M M1K Likely Oncogenic Loss-of-function 24947018, 22137796 -B2M M1I Likely Oncogenic Loss-of-function 11894933, 24947018 -B2M Truncating Mutations Likely Oncogenic Likely Loss-of-function 25594174, 25294904, 22833104, 16730261, 22137796, 23784959, 9637706, 1898655 -SRC Amplification Likely Oncogenic Likely Gain-of-function 24788409, 11114744, 15060621, 22589274 Zehir A et al. Nature Medicine, 2017 http://doi:10.1038/nm.4333 -SRC Q531* Likely Oncogenic Gain-of-function 9988270 -GATA3 Amplification Likely Oncogenic Likely Gain-of-function 20154722, 11441075, 18471881, 16087702, 24448324, 20855495, 21779441 -GATA3 R177Pfs*126 Likely Oncogenic Loss-of-function 26268891 -GATA3 Deletion Likely Oncogenic Likely Loss-of-function 10935639, 15361840, 23426732, 26637396, 24758297, 7829479 -GATA3 Truncating Mutations Likely Oncogenic Likely Loss-of-function 23426732, 18242514, 26637396, 27588951, 24758297 -BARD1 Truncating Mutations Likely Oncogenic Likely Loss-of-function -BARD1 Deletion Likely Oncogenic Likely Loss-of-function 20029420, 17848578, 20842729 -CCND1 256_286trunc Likely Oncogenic Gain-of-function 17299095, 9832503, 16732330, 9926916 -CCND1 C47S Likely Oncogenic Gain-of-function 24145436, 27713153 -CCND1 Y44D Likely Oncogenic Gain-of-function 24145436, 27713153 -CCND1 L283_D294del Likely Oncogenic Likely Gain-of-function 9832503, 16732330 -CCND1 T286A Oncogenic Gain-of-function 16732330, 11124803 -CCND1 D289del Oncogenic Gain-of-function 9832503, 16732330 -CCND1 P287S Likely Oncogenic Likely Gain-of-function 16732330, 12955092, 12615961 -CCND1 CCND1-IGH Fusion Likely Oncogenic Gain-of-function 14514791, 25596256, 16690963, 16402392 -CCND1 P287T Oncogenic Gain-of-function 9832503, 16732330, 12955092 -CCND1 P287A Likely Oncogenic Gain-of-function 16732330, 12615961 -CCND1 Amplification Oncogenic Gain-of-function 9832503, 20164920, 20074063, 8114739, 10508165, 11486031, 16393691, 9792703, 19020303, 21734724 -CCND1 Truncating Mutations Likely Oncogenic Likely Gain-of-function 28483394, 19823025 -CCND1 D289_D292del Likely Oncogenic Likely Gain-of-function 9832503, 16732330 -CCND1 T286I Oncogenic Gain-of-function 9832503, 16732330, 11124803 -BCL2 IGH-BCL2 Fusion Oncogenic Gain-of-function 23939148, 3500184, 18202696, 3874430, 10910891, 2875799, 23892979 -KEAP1 G480W Likely Oncogenic Likely Loss-of-function 24322982 -KEAP1 R272C Oncogenic Loss-of-function 18316592 -KEAP1 D422N Oncogenic Loss-of-function 24322982 -KEAP1 C23Y Likely Oncogenic Loss-of-function 17822677 -KEAP1 R470C Oncogenic Loss-of-function 24322982 -KEAP1 Deletion Likely Oncogenic Likely Loss-of-function 17020408, 24142871 -KEAP1 Truncating Mutations Likely Oncogenic Likely Loss-of-function 17020408, 24142871, 24322982 -KEAP1 G430C Oncogenic Loss-of-function 18316592 -KEAP1 R415G Oncogenic Loss-of-function 18316592 -KEAP1 R320Q Oncogenic Loss-of-function 24322982 -KEAP1 S243C Oncogenic Loss-of-function 24322982 -KEAP1 V155F Oncogenic Loss-of-function 24322982 -KEAP1 G333S Oncogenic Loss-of-function 23912815 -KEAP1 G423V Oncogenic Loss-of-function 24322982 -KEAP1 G333C Oncogenic Loss-of-function 19818716 -KEAP1 G186R Oncogenic Loss-of-function 24322982 -PTCH1 Truncating Mutations Likely Oncogenic Likely Loss-of-function 8782823 -PTCH1 R571W Likely Neutral Likely Neutral 24368541 -PTEN A126V Oncogenic Loss-of-function 21828076 -PTEN M199del Oncogenic Loss-of-function 11051241 -PTEN G129A Likely Oncogenic Likely Loss-of-function 21828076, 26619011 -PTEN G127N Oncogenic Loss-of-function 21828076 -PTEN G165R Likely Oncogenic Loss-of-function 10866302 -PTEN R173H Oncogenic Loss-of-function 10866302, 24721394 -PTEN G127E Oncogenic Loss-of-function 21828076 -PTEN S170R Oncogenic Loss-of-function 9467011, 10866302 -PTEN G165V Oncogenic Loss-of-function 9467011, 21828076 -PTEN H93Q Oncogenic Loss-of-function 21828076 -PTEN F154L Oncogenic Loss-of-function 19329485 -PTEN D92G Oncogenic Loss-of-function 21828076 -PTEN R130A Oncogenic Loss-of-function 21828076 -PTEN L108P Likely Oncogenic Loss-of-function 25527629 -PTEN A34D Oncogenic Loss-of-function 21828076 -PTEN A126G Oncogenic Loss-of-function 21828076 -PTEN K125E Oncogenic Loss-of-function 20926450, 21828076 -PTEN M35R Oncogenic Loss-of-function 21828076 -PTEN D162G Oncogenic Loss-of-function 21828076 -PTEN K125R Likely Neutral Neutral 21828076 -PTEN D24N Likely Oncogenic Likely Loss-of-function 17213812 -PTEN L112R Oncogenic Loss-of-function 10866302 -PTEN K125L Oncogenic Loss-of-function 21828076 -PTEN H123Q Oncogenic Loss-of-function 21828076 -PTEN I122L Oncogenic Loss-of-function 21828076 -PTEN R335L Oncogenic Loss-of-function 21828076 -PTEN C124R Oncogenic Loss-of-function 9467011, 21828076, 10866302 -PTEN R130* Oncogenic Loss-of-function 24721394 -PTEN T401I Likely Oncogenic Loss-of-function 10866302 -PTEN H93R Oncogenic Loss-of-function 21828076 -PTEN T319del Oncogenic Loss-of-function 10468583 -PTEN F341V Oncogenic Loss-of-function 11051241, 10866302 -PTEN C105F Likely Oncogenic Loss-of-function 10866302 -PTEN G251C Likely Oncogenic Loss-of-function 10866302 -PTEN S227F Likely Oncogenic Loss-of-function 10866302 -PTEN D92N Likely Oncogenic Loss-of-function 21828076 -PTEN L23F Oncogenic Loss-of-function 17213812 -PTEN R159G Likely Oncogenic Loss-of-function 17942903 -PTEN T131L Oncogenic Loss-of-function 21828076 -PTEN F347L Oncogenic Loss-of-function 10866302 -PTEN K342N Likely Oncogenic Loss-of-function 10866302 -PTEN I122V Likely Neutral Neutral 21828076 -PTEN A39P Oncogenic Loss-of-function 25527629 -PTEN G20E Likely Oncogenic Loss-of-function 17213812, 10866302 -PTEN L112P Oncogenic Loss-of-function 25527629, 10866302 -PTEN Y65C Oncogenic Loss-of-function 20926450, 19457929 -PTEN D24Y Oncogenic Loss-of-function 17213812 -PTEN L345Q Likely Oncogenic Loss-of-function 10866302 -PTEN Y27S Likely Oncogenic Loss-of-function 10866302 -PTEN A126S Oncogenic Loss-of-function 21828076 -PTEN V217D Oncogenic Loss-of-function 21828076 -PTEN R15S Oncogenic Gain-of-function 17213812 -PTEN R335* Oncogenic Loss-of-function 23475934 -PTEN R15K Oncogenic Loss-of-function 21828076 -PTEN P96Q Oncogenic Loss-of-function 21828076 -PTEN M134L Likely Oncogenic Loss-of-function 10866302 -PTEN G129R Oncogenic Loss-of-function 21828076, 25527629, 10866302, 9811831 -PTEN D92H Oncogenic Loss-of-function 21828076 -PTEN R130G Oncogenic Loss-of-function 21828076, 25527629, 11051241, 10866302, 9811831 -PTEN H93Y Oncogenic Loss-of-function 21828076, 10866302 -PTEN C124S Likely Oncogenic Loss-of-function 25527629, 9811831 -PTEN D92V Oncogenic Loss-of-function 21828076 -PTEN D162H Oncogenic Loss-of-function 23840064 -PTEN G129E Oncogenic Loss-of-function 9467011, 21828076, 25527629, 10866302, 9811831 -PTEN K62R Oncogenic Loss-of-function 20926450, 19457929 -PTEN R161G Oncogenic Loss-of-function 21828076 -PTEN T167A Oncogenic Loss-of-function 21828076 -PTEN D252G Oncogenic Loss-of-function 25527629 -PTEN A121V Likely Neutral Neutral 21828076 -PTEN A121P Likely Oncogenic Loss-of-function 10866302 -PTEN R130K Oncogenic Loss-of-function 21828076 -PTEN F241S Oncogenic Loss-of-function 21828076, 25527629 -PTEN K125M Oncogenic Loss-of-function 21828076 -PTEN H61R Likely Oncogenic Loss-of-function 10866302 -PTEN Y68H Likely Oncogenic Loss-of-function 23840064, 9467011, 10866302 -PTEN G36R Oncogenic Loss-of-function 21828076 -PTEN Y68D Oncogenic Loss-of-function 21828076 -PTEN F21A Likely Oncogenic Loss-of-function 17213812 -PTEN H123D Oncogenic Loss-of-function 21828076 -PTEN I32del Likely Oncogenic Loss-of-function 24904117, 10560660, 22817889, 9326929, 24293293 -PTEN V343L Oncogenic Loss-of-function 21828076 -PTEN S362L Likely Neutral Likely Neutral 19329485 -PTEN T131S Likely Neutral Neutral 21828076 -PTEN D331G Likely Oncogenic Loss-of-function 10866302 -PTEN E157G Oncogenic Loss-of-function 21828076 -PTEN N94I Oncogenic Loss-of-function 21828076 -PTEN V343E Oncogenic Loss-of-function 10866302 -PTEN Y155C Oncogenic Loss-of-function 21828076, 11051241, 10866302 -PTEN H61D Oncogenic Loss-of-function 21828076 -PTEN N48K Oncogenic Loss-of-function 21828076, 25527629 -PTEN V133I Likely Oncogenic Loss-of-function 10866302 -PTEN C136R Likely Oncogenic Loss-of-function 23475934 -PTEN G165E Oncogenic Loss-of-function 21828076 -PTEN Q110R Likely Neutral Likely Neutral 19329485 -PTEN R130Q Likely Oncogenic Loss-of-function 10866302 -PTEN G129D Oncogenic Loss-of-function 21828076 -PTEN A121E Oncogenic Loss-of-function 21828076 -PTEN Truncating Mutations Likely Oncogenic Likely Loss-of-function 17218262, 11237521 -PTEN S10N Likely Oncogenic Loss-of-function 10866302 -PTEN N276S Likely Oncogenic Loss-of-function 25527629 -PTEN A126D Oncogenic Loss-of-function 21828076 -PTEN I122S Oncogenic Loss-of-function 21828076 -PTEN K289E Likely Oncogenic Loss-of-function 10866302 -PTEN I168F Oncogenic Loss-of-function 21828076 -PTEN D92E Oncogenic Loss-of-function 21828076 -PTEN R173P Likely Oncogenic Loss-of-function 10866302 -PTEN T160I Oncogenic Loss-of-function 21828076 -PTEN Y174N Likely Oncogenic Loss-of-function 10866302 -PTEN I33del Likely Oncogenic Loss-of-function 24904117, 10560660, 22817889, 9326929, 24293293 -PTEN S170N Likely Oncogenic Loss-of-function 10866302 -PTEN H118P Oncogenic Loss-of-function 21828076, 25527629 -PTEN K128R Oncogenic Loss-of-function 21828076 -PTEN D107Y Likely Oncogenic Loss-of-function 10866302 -PTEN P95L Oncogenic Loss-of-function 21828076 -PTEN C136Y Oncogenic Loss-of-function 10866302 -PTEN L325F Oncogenic Loss-of-function 19329485 -PTEN G44D Oncogenic Loss-of-function 21828076 -PTEN K128N Oncogenic Loss-of-function 21828076 -PTEN K128Q Oncogenic Loss-of-function 25447541 -PTEN D92A Oncogenic Loss-of-function 21828076 -PTEN P169H Oncogenic Loss-of-function 21828076 -PTEN H123Y Oncogenic Loss-of-function 21828076 -PTEN V369G Likely Neutral Neutral 21828076, 10866302 -PTEN Y16C Likely Oncogenic Loss-of-function 10866302 -PTEN D326N Oncogenic Loss-of-function 21828076, 25527629 -PTEN T319A Likely Oncogenic Likely Loss-of-function 26166433 -PTEN R173C Likely Oncogenic Loss-of-function 10866302 -PTEN L42R Likely Oncogenic Loss-of-function 10866302 -PTEN Deletion Oncogenic Loss-of-function 12844284, 9697695, 12370746, 21430697 -PTEN C124N Oncogenic Loss-of-function 21828076 -PTEN H93D Oncogenic Loss-of-function 21828076 -PTEN K128T Oncogenic Loss-of-function 21828076 -PTEN D301N Likely Neutral Likely Neutral 19329485 -PTEN P95S Oncogenic Loss-of-function 19329485 -PTEN T131A Oncogenic Loss-of-function 21828076 -PTEN L181P Oncogenic Loss-of-function 21828076 -PTEN T131I Oncogenic Loss-of-function 21828076 -PTEN P38L Likely Oncogenic Likely Loss-of-function 23039341 -PTEN C71Y Oncogenic Loss-of-function 11051241, 10866302 -PTEN R130L Oncogenic Loss-of-function 9467011, 25527629, 10866302 -BCOR Deletion Likely Oncogenic Likely Loss-of-function 26847029, 10582652, 2212066 -BCOR BCOR-CCNB3 Fusion Oncogenic Likely Switch-of-function 22387997 -BCOR BCOR-RARA Fusion Oncogenic Likely Switch-of-function 20807888 -BCOR ZC3H7B-BCOR Fusion Oncogenic Likely Switch-of-function 23580382 -BCOR Truncating Mutations Likely Oncogenic Likely Loss-of-function 26847029, 25550361, 22237022, 22012066, 24047651 -BCOR Fusions Likely Oncogenic Likely Switch-of-function 24515802 -RNF43 Truncating Mutations Likely Oncogenic Likely Loss-of-function 23847203, 23096461, 25344691 -CIC Fusions Likely Oncogenic Likely Loss-of-function 22072439, 25007147, 28188754 -CIC R201W Likely Oncogenic Likely Loss-of-function 22072542, 25193860 -CIC R1515H Likely Oncogenic Likely Loss-of-function 22072542, 25193860 -CIC Truncating Mutations Likely Oncogenic Likely Loss-of-function 22072542, 22588899, 21817013, 24117486, 24086756 -CIC CIC-DUX4 Fusion Oncogenic Switch-of-function 22072439, 16717057 -INPP4B Deletion Likely Oncogenic Likely Loss-of-function 25883023, 25428846, 19647222, 21127264 -INPP4B Truncating Mutations Likely Oncogenic Likely Loss-of-function 25428846, 19647222, 21127264 -STAT3 F384V Likely Oncogenic Likely Gain-of-function 22751495, 17881745, 17676033, 18602572, 26619011 -STAT3 D661Y Likely Oncogenic Gain-of-function 25586472 -STAT3 F384Y Likely Oncogenic Likely Gain-of-function 22751495, 17881745, 17676033, 18602572, 26619011 -STAT3 Y640F Oncogenic Gain-of-function 25586472, 25873174, 22591296 -STAT3 F384L Likely Oncogenic Likely Gain-of-function 22751495, 17881745, 17676033, 18602572, 26619011 -STAT3 S614R Likely Oncogenic Gain-of-function 25586472, 25709890 -STAT3 D661V Likely Oncogenic Gain-of-function 22591296 -STAT3 H410R Likely Oncogenic Gain-of-function 26419508 -WHSC1L1 Amplification Inconclusive Inconclusive 18757432, 24874471, 21664949 -PRDM1 P48R Likely Oncogenic Loss-of-function 21156281 -PRDM1 C569Y Likely Oncogenic Loss-of-function 21156281 -PRDM1 Truncating Mutations Likely Oncogenic Likely Loss-of-function 20651244, 27568520, 16424392, 21156281, 16492805 -PRDM1 Y149D Likely Oncogenic Loss-of-function 21156281 -PRDM1 P48T Likely Oncogenic Loss-of-function 21156281 -PRDM1 Deletion Likely Oncogenic Likely Loss-of-function 27568520, 16424392, 21156281, 16492805 -JAK1 V658F Oncogenic Gain-of-function 20868368, 19139102, 21393331 -JAK1 A634D Oncogenic Gain-of-function 19139102 -JAK1 L783F Oncogenic Gain-of-function 21393331 -JAK1 F958S Oncogenic Gain-of-function 21393331 -JAK1 R724H Oncogenic Gain-of-function 18362171 -JAK1 S729C Oncogenic Gain-of-function 23788652 -JAK1 K1026E Oncogenic Gain-of-function 20868368 -JAK1 S703I Oncogenic Gain-of-function 24825865, 23788652 -JAK1 F958C Oncogenic Gain-of-function 21393331 -JAK1 A723D Likely Oncogenic Gain-of-function 24735922 -JAK1 Truncating Mutations Likely Oncogenic Likely Loss-of-function 24154688 -JAK1 Y1035C Oncogenic Gain-of-function 20868368 -JAK1 G871E Likely Oncogenic Likely Loss-of-function 16474838 -JAK1 Y652H Likely Oncogenic Gain-of-function 21551237 -JAK1 R879C Oncogenic Gain-of-function 18362171 -JAK1 G1079D Likely Oncogenic Gain-of-function 25873174 -JAK1 K648N Likely Oncogenic Gain-of-function 21551237 -JAK1 L910P Oncogenic Gain-of-function 20868368, 25873174, 23788652 -JAK1 F958V Oncogenic Gain-of-function 21393331 -JAK1 S646F Oncogenic Gain-of-function 19470474 -JAK2 V617F Oncogenic Gain-of-function 12351625, 15793561, 21533163, 19543316 -JAK2 R277K Inconclusive Inconclusive 26419724 -JAK2 Y931C Inconclusive Inconclusive 26419724 -JAK2 K539L Oncogenic Gain-of-function 20585391, 17267906, 21362419 -JAK2 C618R Oncogenic Gain-of-function 22960131 -JAK2 SPAG9-JAK2 Fusion Likely Oncogenic Likely Gain-of-function 25515960, 25951811 -JAK2 I1018W Inconclusive Inconclusive 26419724 -JAK2 G417P Inconclusive Inconclusive 26419724 -JAK2 TEL-JAK2 Fusion Oncogenic Gain-of-function 22733019, 10706877, 9360930, 15676212, 10845925 -JAK2 Fusions Likely Oncogenic Likely Gain-of-function 25207766, 24913195 -JAK2 S1025C Inconclusive Inconclusive 26419724 -JAK2 PAX5-JAK2 Fusion Oncogenic Gain-of-function 25207766, 25515960 -JAK2 Amplification Oncogenic Gain-of-function 20628145 -JAK2 S1039F Inconclusive Inconclusive 26419724 -JAK2 R683K Oncogenic Gain-of-function 18805579, 23748007, 23452118 -JAK2 W1038C Inconclusive Inconclusive 26419724 -JAK2 ATF7IP-JAK2 Fusion Oncogenic Gain-of-function 25207766 -JAK2 N542_E543del Oncogenic Gain-of-function 17267906 -JAK2 R683G Oncogenic Gain-of-function 18805579, 20585391, 23748007, 23452118 -JAK2 D544H Inconclusive Inconclusive 26419724 -JAK2 L1026F Inconclusive Inconclusive 26419724 -JAK2 Y1045* Inconclusive Inconclusive 26419724 -JAK2 I1018F Inconclusive Inconclusive 26419724 -JAK2 F1061W Inconclusive Inconclusive 26419724 -JAK2 F537_K539delinsL Oncogenic Gain-of-function 17267906 -JAK2 BCR-JAK2 Fusion Oncogenic Gain-of-function 25664618, 22549126, 22384256, 25789185, 23904814, 18537978, 16001431, 24913195, 18503828 -JAK2 SSBP2-JAK2 Fusion Likely Oncogenic Likely Gain-of-function 21325169, 18618714 -JAK2 L611V Likely Oncogenic Likely Gain-of-function 20182460 -JAK2 L551P Inconclusive Inconclusive 26419724 -JAK2 H538Q Oncogenic Gain-of-function 17267906 -JAK2 R683T Inconclusive Inconclusive 26419724 -JAK2 V1075F Inconclusive Inconclusive 26419724 -JAK2 R683S Oncogenic Gain-of-function 18805579, 23748007, 23452118 -JAK2 Y1045W Inconclusive Inconclusive 26419724 -JAK2 L983F Inconclusive Inconclusive 26419724 -JAK2 PCM1-JAK2 Fusion Likely Oncogenic Gain-of-function 16034466, 21325169, 23372669, 15805263, 16424865, 24913195 -JAK2 T875N Oncogenic Gain-of-function 20585391, 16804112, 19543316, 21362419 -AURKA F31I Likely Oncogenic Gain-of-function 12881723, 12208850 -AURKA K162D Likely Neutral Loss-of-function 12237287, 25395580 -AURKA Amplification Oncogenic Gain-of-function 9606188, 9771714, 10914715 -STK11 Deletion Likely Oncogenic Likely Loss-of-function 16582077, 21532627, 1627113, 19892943 -STK11 K78I Likely Oncogenic Loss-of-function 9837816 -STK11 W308C Likely Oncogenic Loss-of-function 9837816, 15987703 -STK11 Truncating Mutations Likely Oncogenic Likely Loss-of-function 24652667, 21516316, 19340305, 19892943, 25079552 -STK11 H174R Likely Oncogenic Loss-of-function 25960268 -STK11 D194Y Likely Oncogenic Loss-of-function 26917230 -STK11 F354L Likely Neutral Likely Neutral 15800014, 10676634 -STK11 G163D Likely Oncogenic Loss-of-function 9887330, 14668798, 10430928, 9605748 -STK11 R304W Oncogenic Loss-of-function 9837816, 12552571 -STK11 K78A Likely Oncogenic Loss-of-function 15800014, 14668798 -STK11 A205T Oncogenic Loss-of-function 16407837 -STK11 M136R Likely Oncogenic Loss-of-function 14668798 -STK11 D176N Likely Oncogenic Loss-of-function 9837816, 15987703 -STK11 I177N Oncogenic Loss-of-function 12552571 -STK11 L67P Likely Oncogenic Loss-of-function 9837816, 15987703 -JUN Amplification Oncogenic Gain-of-function 19449367, 17418412 -PTPN11 Q79R Likely Oncogenic Likely Gain-of-function 15834506 -PTPN11 E76K Oncogenic Gain-of-function 15834506, 12717436 -PTPN11 Y62C Likely Oncogenic Gain-of-function 15604238 -PTPN11 G464A Inconclusive Inconclusive 24935154 -PTPN11 P491S Likely Oncogenic Likely Gain-of-function 24891296 -PTPN11 D106A Oncogenic Gain-of-function 18286234 -PTPN11 E76A Oncogenic Gain-of-function 15834506, 12717436 -PTPN11 R498L Inconclusive Inconclusive 24935154 -PTPN11 K590R Likely Neutral Likely Switch-of-function 25823821 -PTPN11 A72V Oncogenic Gain-of-function 15834506 -PTPN11 R498W Likely Oncogenic Likely Loss-of-function 17053061, 24891296 -PTPN11 Deletion Oncogenic Loss-of-function 22869052 -PTPN11 Q510E Likely Oncogenic Likely Loss-of-function 25359717, 21803945, 22058153 -PTPN11 T73I Oncogenic Gain-of-function 15834506 -PTPN11 E139D Likely Oncogenic Likely Gain-of-function 16358218 -PTPN11 V45L Likely Oncogenic Gain-of-function 15604238 -PTPN11 Y63C Likely Oncogenic Gain-of-function 15834506 -PTPN11 I282V Oncogenic Gain-of-function 14974085, 15834506 -PTPN11 T507K Oncogenic Gain-of-function 15604238, 18286234 -PTPN11 E69K Likely Oncogenic Likely Gain-of-function 15604238, 12717436 -PTPN11 D61Y Oncogenic Gain-of-function 15834506, 12717436 -PTPN11 F71I Oncogenic Gain-of-function 15834506 -PTPN11 D61N Oncogenic Gain-of-function 15834506 -PTPN11 A72S Oncogenic Gain-of-function 14974085 -PTPN11 G503V Likely Oncogenic Likely Gain-of-function 15834506 -PTPN11 M504V Oncogenic Gain-of-function 15834506 -PTPN11 T468M Oncogenic Loss-of-function 26742426, 16358218, 25288766 -PTPN11 S502T Likely Oncogenic Gain-of-function 15834506 -PTPN11 N308D Oncogenic Gain-of-function 14974085, 15834506, 12717436 -NF1 R1391S Likely Oncogenic Loss-of-function 8052307, 19573811, 24576830, 9003501, 12509763, 8563751, 7542586 -NF1 Truncating Mutations Likely Oncogenic Likely Loss-of-function 8052307, 26345759, 19573811, 8563751, 23913538, 7542586, 7655472, 10862084, 24576830, 23047742, 10543400, 12509763, 14722914 -NF1 R1276Q Likely Oncogenic Loss-of-function 8052307, 19573811, 24576830, 12509763, 8563751, 22807134, 7542586 -NF1 S1463F Likely Oncogenic Loss-of-function 8052307, 19573811, 24576830, 12509763, 8563751, 22807134, 7542586, 22108604 -NF1 E1356G Likely Oncogenic Loss-of-function 8052307, 19573811, 24576830, 12509763, 8563751, 22807134, 7542586 -NF1 T1324N Likely Oncogenic Loss-of-function 8052307, 19573811, 24576830, 12509763, 8563751, 22807134, 7542586 -NF1 Deletion Likely Oncogenic Loss-of-function 23460398, 8052307, 19573811, 24576830, 12509763, 8563751, 19767589, 7542586, 20513137 -NF1 L1301R Likely Oncogenic Loss-of-function 8052307, 19573811, 24576830, 12509763, 8563751, 22807134, 7542586 -NF1 K1436Q Likely Oncogenic Loss-of-function 8052307, 19573811, 24576830, 12509763, 8563751, 22807134, 7542586 -NF1 R1276P Oncogenic Loss-of-function 9302992, 9219684, 9668168 -NF1 Y489C Oncogenic Loss-of-function 11258625 -NF1 K1423E Oncogenic Loss-of-function 8052307, 19573811, 24576830, 12509763, 8563751, 1568247, 7542586 -NF1 R2450* Likely Oncogenic Likely Loss-of-function 23288408 -NF1 V1398D Likely Oncogenic Loss-of-function 8052307, 19573811, 24576830, 12509763, 8563751, 22807134, 7542586 -NF1 R1204W Likely Oncogenic Loss-of-function 8052307, 19573811, 24576830, 12509763, 8563751, 22807134, 7542586 -NF1 R1391G Likely Oncogenic Loss-of-function 8052307, 19573811, 24576830, 12509763, 8563751, 22807134, 7542586 -NF1 R1204G Likely Oncogenic Loss-of-function 8052307, 19573811, 24576830, 12509763, 8563751, 22807134, 7542586 -FOXL2 Amplification Inconclusive Inconclusive 21623383 -FOXL2 C134W Likely Oncogenic Loss-of-function 24342437, 24817949, 23372819 -PTPRD Deletion Oncogenic Loss-of-function 19478061, 19074898, 26267899 -PTPRD G446E Likely Oncogenic Likely Loss-of-function 19074898, 25113440, 8393854 -PTPRD P1311T Likely Oncogenic Likely Loss-of-function 19478061, 26267899 -PTPRD Truncating Mutations Likely Oncogenic Likely Loss-of-function 19478061, 25113440 -PTPRD V1565I Likely Oncogenic Likely Loss-of-function 19074898 -PTPRD R1088C Likely Oncogenic Likely Loss-of-function 19478061 -BRCA1 E1682K Likely Neutral Likely Neutral 20516115 -BRCA1 C44F Likely Oncogenic Loss-of-function 20103620, 22034435, 23161852, 16403807 -BRCA1 E1282V Likely Neutral Likely Neutral 23867111 -BRCA1 S1715C Likely Oncogenic Likely Loss-of-function 20516115 -BRCA1 K56N Inconclusive Inconclusive 22034435, 16403807 -BRCA1 V1810G Likely Oncogenic Likely Loss-of-function 15004537, 15172985, 20516115 -BRCA1 R1589P Likely Neutral Likely Neutral 23867111 -BRCA1 I124V Inconclusive Inconclusive 23161852 -BRCA1 A1843T Likely Oncogenic Likely Loss-of-function 15172985, 11573086, 12496477 -BRCA1 H1746Q Inconclusive Inconclusive 23867111 -BRCA1 G1770V Likely Oncogenic Loss-of-function 23867111, 23613828 -BRCA1 I1766S Likely Oncogenic Loss-of-function 18680205, 20516115, 17308087 -BRCA1 Q1756fs Oncogenic Loss-of-function 14729053, 23867111, 27454287, 15569676, 9145676, 14576434 -BRCA1 I68K Inconclusive Inconclusive 22034435, 16403807 -BRCA1 E1250K Likely Neutral Likely Neutral 23867111 -BRCA1 W1718C Likely Oncogenic Loss-of-function 15172985, 23867111, 9799248, 20516115 -BRCA1 L1780P Likely Oncogenic Loss-of-function 15172985, 10811118, 20516115 -BRCA1 M1775R Oncogenic Loss-of-function 15004537, 14729053, 10811118, 12427738, 7545954, 8751436, 16101277, 11573086, 15689452, 15569676, 8942979, 10635334, 23161852, 15133502, 7939630, 15172985, 20516115, 21922593, 9159158 -BRCA1 G1788V Likely Oncogenic Loss-of-function 15004537, 15172985, 9796975, 15689452, 20516115 -BRCA1 L1267S Likely Neutral Likely Neutral 23867111 -BRCA1 S1651F Likely Neutral Neutral 23867111, 20516115 -BRCA1 R841Q Likely Neutral Likely Neutral 23867111 -BRCA1 S1101N Likely Neutral Likely Neutral 23867111 -BRCA1 E1836K Likely Oncogenic Likely Loss-of-function 20516115 -BRCA1 I90T Inconclusive Inconclusive 23161852 -BRCA1 F1662S Likely Neutral Likely Neutral 20516115 -BRCA1 S1164I Likely Oncogenic Likely Loss-of-function 18680205 -BRCA1 I42V Likely Neutral Neutral 20103620, 23161852 -BRCA1 A1752V Likely Oncogenic Likely Loss-of-function 20516115 -BRCA1 E33A Likely Oncogenic Likely Loss-of-function 21922593 -BRCA1 D1778Y Likely Neutral Likely Neutral 20516115 -BRCA1 P1856S Likely Neutral Likely Neutral 20516115 -BRCA1 A1830T Likely Neutral Likely Neutral 20516115 -BRCA1 C1697R Likely Oncogenic Loss-of-function 15172985, 20516115, 11157798 -BRCA1 K45T Inconclusive Inconclusive 22034435, 16403807 -BRCA1 T1720A Likely Neutral Likely Neutral 15004537, 15172985, 23867111, 15689452, 20516115 -BRCA1 N1819Y Inconclusive Inconclusive 15004537 -BRCA1 E1644G Likely Neutral Likely Neutral 17308087 -BRCA1 H1686Q Likely Oncogenic Loss-of-function 15172985, 23867111, 12496477 -BRCA1 P1637L Likely Neutral Likely Neutral 9159158 -BRCA1 F1761I Likely Oncogenic Likely Loss-of-function 15172985, 10811118 -BRCA1 P798L Likely Neutral Likely Neutral 23867111 -BRCA1 S153R Likely Neutral Neutral 23161852 -BRCA1 E143K Likely Neutral Likely Neutral 23161852 -BRCA1 W1837R Likely Oncogenic Loss-of-function 15172985, 23867111, 9799248, 8968102, 15689452, 20516115 -BRCA1 M1652K Likely Oncogenic Likely Loss-of-function 15004537, 15172985, 10811118 -BRCA1 R1699W Oncogenic Loss-of-function 15172985, 23867111, 11573086, 12496476, 20516115, 11157798, 7939630 -BRCA1 V1378I Likely Neutral Likely Neutral 23867111 -BRCA1 V1838E Likely Oncogenic Likely Loss-of-function 20516115 -BRCA1 H1421Y Likely Neutral Likely Neutral 15689452 -BRCA1 Y179C Inconclusive Inconclusive 18680205, 23161852 -BRCA1 P1806A Likely Neutral Likely Neutral 15004537, 15172985, 10811118, 20516115, 17308087 -BRCA1 P1776S Inconclusive Inconclusive 15172985, 10196379 -BRCA1 S59R Inconclusive Inconclusive 22034435, 16403807 -BRCA1 P1614S Likely Neutral Likely Neutral 17308087 -BRCA1 I89T Inconclusive Inconclusive 22034435, 16403807 -BRCA1 C39Y Oncogenic Loss-of-function 20103620, 22034435, 23161852, 21922593, 16403807 -BRCA1 L1854P Likely Oncogenic Likely Loss-of-function 20516115 -BRCA1 W1837C Likely Oncogenic Likely Loss-of-function 20516115 -BRCA1 T1773I Likely Oncogenic Likely Loss-of-function 20516115 -BRCA1 R1589H Likely Neutral Likely Neutral 23613828 -BRCA1 K45Q Likely Neutral Likely Neutral 23867111 -BRCA1 E60L Inconclusive Inconclusive 22034435, 16403807 -BRCA1 L1407P Likely Oncogenic Likely Loss-of-function 23867111, 19369211, 15689452, 16793542, 15770685 -BRCA1 S1715R Likely Oncogenic Loss-of-function 15172985, 20516115, 11157798 -BRCA1 S1841N Likely Oncogenic Likely Loss-of-function 15172985, 9799248, 20516115 -BRCA1 S1301R Likely Neutral Likely Neutral 23867111 -BRCA1 E29V Inconclusive Inconclusive 22034435, 16403807 -BRCA1 V1736G Likely Oncogenic Likely Loss-of-function 20516115 -BRCA1 I31M Likely Neutral Neutral 20103620, 23161852, 16403807 -BRCA1 T37R Likely Oncogenic Loss-of-function 20103620, 22034435, 23161852, 16403807 -BRCA1 P1856T Inconclusive Inconclusive 15172985 -BRCA1 C64G Likely Oncogenic Loss-of-function 20103620, 23867111, 22034435, 10635334, 23161852, 16403807 -BRCA1 R71G Inconclusive Inconclusive 20103620, 11385711, 23161852 -BRCA1 K50L Inconclusive Inconclusive 22034435, 16403807 -BRCA1 G1706A Likely Neutral Neutral 15172985, 23867111, 15689452, 15923272, 20516115 -BRCA1 K1702E Likely Oncogenic Likely Loss-of-function 15172985, 10811118 -BRCA1 R496C Likely Neutral Likely Neutral 18036263, 18497862 -BRCA1 S4F Inconclusive Inconclusive 23867111 -BRCA1 L246V Likely Neutral Likely Neutral 23867111 -BRCA1 K45N Inconclusive Inconclusive 22034435, 16403807 -BRCA1 C24Y Inconclusive Inconclusive 22034435, 16403807 -BRCA1 N1730S Likely Neutral Likely Neutral 15172985, 20516115 -BRCA1 Y1703S Likely Oncogenic Likely Loss-of-function 23613828 -BRCA1 R1751P Likely Oncogenic Likely Loss-of-function 15172985, 20516115 -BRCA1 V1653M Likely Oncogenic Likely Loss-of-function 15004537, 15172985, 20516115 -BRCA1 E1060A Likely Neutral Likely Neutral 23867111 -BRCA1 S308A Inconclusive Inconclusive 23867111 -BRCA1 C61G Likely Oncogenic Loss-of-function 14729053, 20103620, 23867111, 22034435, 15569676, 23161852, 16403807 -BRCA1 K1487R Likely Oncogenic Likely Loss-of-function 18992264 -BRCA1 C24R Likely Oncogenic Loss-of-function 20103620, 23161852 -BRCA1 S4P Inconclusive Inconclusive 22034435, 16403807 -BRCA1 M1783L Likely Neutral Likely Neutral 20516115 -BRCA1 V271L Likely Neutral Neutral 23867111 -BRCA1 A1823T Likely Neutral Likely Neutral 15172985, 12142080, 20516115 -BRCA1 T1691K Likely Oncogenic Likely Loss-of-function 20516115 -BRCA1 A1752G Likely Neutral Likely Neutral 23842040 -BRCA1 H1402Y Likely Neutral Likely Neutral 15689452 -BRCA1 D1778H Inconclusive Inconclusive 15172985, 9809041 -BRCA1 L165P Likely Neutral Likely Neutral 23867111 -BRCA1 V1804A Inconclusive Inconclusive 15004537 -BRCA1 W1718S Likely Oncogenic Likely Loss-of-function 15172985, 20516115 -BRCA1 R133H Likely Neutral Neutral 23161852 -BRCA1 T1773S Likely Neutral Likely Neutral 15172985, 20516115 -BRCA1 D1692H Likely Oncogenic Likely Loss-of-function 20516115 -BRCA1 D1692Y Likely Oncogenic Likely Loss-of-function 15172985, 20516115 -BRCA1 D695N Likely Neutral Likely Neutral 23867111 -BRCA1 L1657P Likely Oncogenic Likely Loss-of-function 15172985, 12496477 -BRCA1 R866C Likely Neutral Likely Neutral 23867111 -BRCA1 G57R Inconclusive Inconclusive 22034435, 16403807 -BRCA1 A1708V Likely Oncogenic Likely Loss-of-function 20516115 -BRCA1 H1805P Likely Neutral Likely Neutral 20516115 -BRCA1 N1819S Likely Neutral Likely Neutral 15172985, 20516115 -BRCA1 V191D Likely Neutral Likely Neutral 23161852 -BRCA1 G1656D Likely Oncogenic Likely Loss-of-function 20516115 -BRCA1 I89N Inconclusive Inconclusive 22034435, 16403807 -BRCA1 K50E Inconclusive Inconclusive 22034435, 16403807 -BRCA1 A1789S Likely Neutral Likely Neutral 20516115 -BRCA1 M1008I Likely Neutral Likely Neutral 23867111 -BRCA1 A1752P Likely Oncogenic Loss-of-function 15172985, 15689452, 20516115 -BRCA1 K65M Inconclusive Inconclusive 22034435, 16403807 -BRCA1 V1804D Inconclusive Inconclusive 15004537, 15172985, 23867111, 15350310, 20516115, 17308087 -BRCA1 D1778N Likely Neutral Likely Neutral 15172985, 20516115 -BRCA1 R1753T Likely Oncogenic Loss-of-function 23867111, 20516115, 17308087 -BRCA1 R1758G Inconclusive Inconclusive 15172985, 9544765 -BRCA1 L1844R Likely Neutral Likely Neutral 20516115 -BRCA1 Truncating Mutations Likely Oncogenic Likely Loss-of-function 12483515, 11358863, 20608970, 12947386 -BRCA1 V191I Likely Neutral Likely Neutral 23867111 -BRCA1 Y1703H Likely Oncogenic Likely Loss-of-function 15172985, 10811118, 11573086 -BRCA1 V1713A Oncogenic Loss-of-function 20516115, 17308087, 9159158 -BRCA1 S1613C Likely Neutral Likely Neutral 18992264 -BRCA1 M1689T Likely Oncogenic Likely Loss-of-function 20516115 -BRCA1 C47G Likely Oncogenic Loss-of-function 20103620, 22034435, 23161852, 16403807 -BRCA1 T47D Likely Neutral Likely Neutral 15569676 -BRCA1 M1663L Likely Neutral Likely Neutral 20516115 -BRCA1 S1613G Likely Neutral Likely Neutral 9159158 -BRCA1 R170W Likely Neutral Likely Neutral 23867111 -BRCA1 F1695L Likely Neutral Likely Neutral 15172985, 17161371, 20516115 -BRCA1 L63F Inconclusive Inconclusive 22034435, 16403807 -BRCA1 C44Y Oncogenic Loss-of-function 22034435, 21922593, 16403807 -BRCA1 C1767S Likely Neutral Likely Neutral 23867111 -BRCA1 T1691I Likely Oncogenic Likely Loss-of-function 23867111, 20516115 -BRCA1 F1704S Likely Oncogenic Likely Loss-of-function 15172985, 11573086, 12496477 -BRCA1 C360R Likely Neutral Likely Neutral 23867111 -BRCA1 E362H Likely Neutral Likely Neutral 23867111 -BRCA1 R170Q Likely Neutral Neutral 23161852 -BRCA1 M1411T Inconclusive Inconclusive 23867111, 19369211, 16793542, 15770685 -BRCA1 W1782C Likely Neutral Likely Neutral 23867111 -BRCA1 E1586G Likely Neutral Likely Neutral 23613828 -BRCA1 G1743R Likely Oncogenic Likely Loss-of-function 15172985, 12496477 -BRCA1 W1837G Likely Oncogenic Likely Loss-of-function 15172985, 9799248, 20516115 -BRCA1 G1706E Likely Oncogenic Loss-of-function 15172985, 23867111, 20516115, 17308087 -BRCA1 T1852S Inconclusive Inconclusive 15172985 -BRCA1 L358R Likely Neutral Likely Neutral 23867111 -BRCA1 S1448G Likely Neutral Likely Neutral 23867111 -BRCA1 G1763V Likely Oncogenic Likely Loss-of-function 20516115 -BRCA1 C39S Inconclusive Inconclusive 22034435, 16403807 -BRCA1 Q1826H Likely Neutral Likely Neutral 18992264, 20516115 -BRCA1 D1733G Likely Neutral Likely Neutral 15172985, 10811118, 17161371, 20516115, 11157798 -BRCA1 Deletion Likely Oncogenic Likely Loss-of-function 12483515, 18501021, 27452521, 12670888, 9354803 -BRCA1 L147F Likely Neutral Likely Neutral 23867111 -BRCA1 M1628V Likely Oncogenic Likely Loss-of-function 15689452 -BRCA1 M1400V Inconclusive Inconclusive 23867111, 19369211, 16793542, 15770685 -BRCA1 L82P Inconclusive Inconclusive 22034435, 16403807 -BRCA1 V1736A Likely Oncogenic Loss-of-function 15004537, 15172985, 23867111, 20516115, 17308087 -BRCA1 E1794D Likely Neutral Likely Neutral 23867111, 20516115, 17308087 -BRCA1 W1718L Likely Oncogenic Likely Loss-of-function 23613828 -BRCA1 S1715N Likely Oncogenic Loss-of-function 15172985, 20516115, 11157798 -BRCA1 M1783I Likely Neutral Likely Neutral 20516115 -BRCA1 L1564P Likely Oncogenic Likely Loss-of-function 17308087 -BRCA1 V1665M Likely Neutral Likely Neutral 15172985, 20516115, 11157798 -BRCA1 H41R Likely Oncogenic Loss-of-function 20103620, 22034435, 23161852, 16403807 -BRCA1 S1140G Likely Neutral Likely Neutral 23867111 -BRCA1 Y856H Likely Neutral Likely Neutral 23867111 -BRCA1 I26N Inconclusive Inconclusive 22034435, 16403807 -BRCA1 M1663K Likely Neutral Likely Neutral 20516115 -BRCA1 D1739E Likely Oncogenic Likely Loss-of-function 15004537, 15172985, 20516115 -BRCA1 T77M Inconclusive Inconclusive 22034435, 16403807 -BRCA1 R1699L Likely Oncogenic Likely Loss-of-function 15172985, 11573086, 20516115 -BRCA1 G1738R Likely Oncogenic Loss-of-function 15172985, 20516115, 17308087 -BRCA1 K1110del Likely Neutral Likely Neutral 23867111 -BRCA1 V1714G Likely Oncogenic Likely Loss-of-function 20516115 -BRCA1 N132K Likely Neutral Neutral 23867111, 18680205, 23161852 -BRCA1 R1751Q Likely Neutral Likely Neutral 9150149, 15172985, 20516115 -BRCA1 T826K Inconclusive Inconclusive 23867111, 10635334 -BRCA1 V1688del Likely Oncogenic Likely Loss-of-function 23867111 -BRCA1 D1818G Inconclusive Inconclusive 20516115 -BRCA1 Q1409L Likely Neutral Likely Neutral 23613828 -BRCA1 R1443G Likely Neutral Likely Neutral 23867111, 17308087 -BRCA1 P1859R Likely Neutral Likely Neutral 15172985, 20516115 -BRCA1 G1803A Likely Oncogenic Likely Loss-of-function 15172985, 20516115 -BRCA1 D1344H Inconclusive Inconclusive 25416589 -BRCA1 G1788D Likely Oncogenic Likely Loss-of-function 15172985, 20516115, 17308087 -BRCA1 C39R Inconclusive Inconclusive 22034435, 16403807 -BRCA1 R1699Q Likely Oncogenic Loss-of-function 15172985, 23867111, 11573086, 20516115, 11157798 -BRCA1 L52F Likely Neutral Neutral 20103620, 22034435, 23161852, 16403807 -BRCA1 H1862L Likely Neutral Likely Neutral 23867111 -BRCA1 D1739V Likely Oncogenic Loss-of-function 23867111, 20516115 -BRCA1 P142H Likely Neutral Neutral 23867111, 23161852 -BRCA1 Q12Y Inconclusive Inconclusive 22034435, 16403807 -BRCA1 Q1785H Likely Neutral Likely Neutral 20516115, 17308087 -BRCA1 S186Y Likely Neutral Neutral 23867111, 23161852 -BRCA1 T1685A Likely Oncogenic Likely Loss-of-function 15172985, 20516115 -BRCA1 K38N Inconclusive Inconclusive 22034435, 16403807 -BRCA1 I21V Likely Neutral Neutral 20103620, 23161852 -BRCA1 M1775V Likely Neutral Likely Neutral 15172985, 11573086, 8942979 -BRCA1 S1497A Likely Neutral Likely Neutral 23867111 -BRCA1 P1771L Likely Neutral Likely Neutral 15172985, 20516115 -BRCA1 C1787S Likely Neutral Likely Neutral 15172985, 11573086, 20516115 -BRCA1 N550H Likely Neutral Likely Neutral 18680205 -BRCA1 P1812S Inconclusive Inconclusive 15172985 -BRCA1 V1534M Likely Neutral Likely Neutral 23867111, 17308087 -BRCA1 A1708E Oncogenic Loss-of-function 15172985, 23867111, 8751436, 11573086, 15923272, 8942979, 20516115, 21922593, 11157798, 9159158, 7939630 -BRCA1 M1R Likely Oncogenic Likely Loss-of-function 21922593 -BRCA1 H1746N Likely Oncogenic Likely Loss-of-function 15172985, 20516115 -BRCA1 E1660G Likely Oncogenic Likely Loss-of-function 15172985, 12496477 -BRCA1 Y105C Likely Neutral Neutral 23867111, 23161852 -BRCA1 V1833E Likely Oncogenic Likely Loss-of-function 15172985, 10811118 -BRCA1 Q1756C Likely Oncogenic Likely Loss-of-function 8942979 -BRCA1 V1696L Likely Oncogenic Likely Loss-of-function 15172985, 20516115 -BRCA1 M1775E Likely Oncogenic Likely Loss-of-function 15172985, 11573086, 8942979 -BRCA1 D96N Inconclusive Inconclusive 22034435, 16403807 -BRCA1 D67Y Likely Neutral Neutral 20103620, 23867111, 23161852 -BRCA1 T1685I Likely Oncogenic Loss-of-function 15172985, 15689452, 20516115 -BRCA1 M18T Oncogenic Loss-of-function 20103620, 23867111, 23161852, 21922593 -BRCA1 S1655F Likely Oncogenic Loss-of-function 15004537, 23867111, 20516115, 17308087 -BRCA1 V1809F Likely Oncogenic Likely Loss-of-function 15172985, 15689452, 20516115 -BRCA1 S1651P Inconclusive Inconclusive 23867111 -BRCA1 T1700A Likely Oncogenic Loss-of-function 20516115, 17308087 -BRCA1 Y1853* Oncogenic Loss-of-function 15004537, 14729053, 8942979, 15569676, 21922593 -BRCA1 A1843P Likely Oncogenic Likely Loss-of-function 15172985, 11595708, 20516115 -BRCA1 I1807S Likely Oncogenic Likely Loss-of-function 15172985, 12496477 -BRCA1 M1775K Likely Oncogenic Loss-of-function 15172985, 18285836, 11573086, 8942979, 20516115 -BRCA1 M1689R Likely Oncogenic Likely Loss-of-function 15172985, 20516115 -BRCA1 L1664P Likely Neutral Likely Neutral 15172985, 20516115, 17308087 -BRCA1 D1692N Likely Neutral Likely Neutral 15172985, 10196379, 20516115, 11157798 -BRCA1 L28P Inconclusive Inconclusive 22034435, 16403807 -BRCA1 F1734S Likely Oncogenic Likely Loss-of-function 15172985, 20516115 -BRCA1 S72R Inconclusive Inconclusive 22034435, 16403807 -BRCA1 P1812R Likely Neutral Likely Neutral 23867111 -BRCA1 F1761S Likely Oncogenic Loss-of-function 15172985, 10811118, 20516115 -BRCA1 Y1853C Likely Oncogenic Loss-of-function 23842040, 20516115 -BRCA1 V1808A Likely Neutral Likely Neutral 15004537, 15172985, 20516115 -BRCA1 E23fs Oncogenic Loss-of-function 14729053, 23867111, 27454287, 27454289, 15569676, 9145676, 14576434 -BRCA1 H1686R Likely Oncogenic Likely Loss-of-function 23867111 -BRCA1 V1809A Likely Neutral Likely Neutral 15172985, 20516115 -BRCA1 V1833M Likely Oncogenic Likely Loss-of-function 15004537, 18992264, 15172985, 12142080, 20516115 -BRCA1 C27A Likely Oncogenic Loss-of-function 20103620, 23161852 -BRCA1 N1236K Likely Neutral Likely Neutral 23867111 -BRCA1 L1705P Likely Oncogenic Likely Loss-of-function 15172985, 10811118, 11573086 -BRCA1 M1652T Inconclusive Inconclusive 15004537, 15172985, 9585608, 20516115 -BRCA1 F79S Inconclusive Inconclusive 22034435, 16403807 -BRCA1 S1512I Likely Neutral Likely Neutral 18680205, 15689452 -BRCA1 M18K Inconclusive Inconclusive 22034435, 16403807 -BRCA1 F1734L Likely Oncogenic Likely Loss-of-function 15172985, 12496477 -BRCA1 E1214K Likely Neutral Likely Neutral 23867111 -BRCA1 S1486C Likely Neutral Likely Neutral 23867111 -BRCA1 S1473P Likely Neutral Likely Neutral 23613828 -BRCA1 R1726G Likely Neutral Likely Neutral 20516115 -BRCA1 D245V Likely Neutral Likely Neutral 23867111 -BRCA1 T231M Likely Neutral Likely Neutral 23867111 -BRCA1 A1669S Likely Neutral Likely Neutral 15172985, 20516115, 11157798 -BRCA1 N1647K Likely Neutral Likely Neutral 20516115 -BRCA1 S1841R Likely Oncogenic Likely Loss-of-function 20516115 -BRCA1 D1546N Inconclusive Inconclusive 17308087 -BRCA1 D1739G Likely Oncogenic Loss-of-function 15004537, 15172985, 23867111, 20516115 -BRCA1 V11A Inconclusive Inconclusive 18493658 -BRCA1 P1771R Likely Neutral Likely Neutral 20516115 -BRCA1 S1297del Likely Neutral Likely Neutral 23867111 -BRCA1 Q1811R Likely Oncogenic Likely Loss-of-function 15172985, 20516115 -BRCA1 L668F Likely Neutral Likely Neutral 23867111 -BRCA1 M1783T Inconclusive Inconclusive 15004537, 15172985, 20516115 -BRCA1 D1778G Likely Neutral Likely Neutral 15172985, 20516115 -BRCA1 N810Y Likely Neutral Likely Neutral 23867111 -BRCA1 P1749R Oncogenic Loss-of-function 14729053, 15172985, 8751436, 15569676, 10635334, 20516115, 21922593, 9159158 -BRCA1 V1741G Likely Oncogenic Likely Loss-of-function 12497638, 15172985, 20516115 -BRCA1 I15T Inconclusive Inconclusive 22034435, 16403807 -BRCA1 T1720I Likely Neutral Likely Neutral 15004537 -BRCA1 S1722F Likely Oncogenic Loss-of-function 15172985, 9799248, 10196379, 20516115 -BRCA1 D1739Y Likely Oncogenic Likely Loss-of-function 15172985, 20516115 -BRCA1 M1628T Likely Neutral Likely Neutral 23867111, 15350310, 15689452 -BRCA1 S988A Likely Neutral Likely Neutral 23867111 -BRCA1 M1652I Likely Neutral Likely Neutral 18992264, 15172985, 23867111, 9326340, 12215251, 9523200, 20516115, 21922593, 9159158 -BRCA1 S1841A Likely Oncogenic Likely Loss-of-function 21922593 -BRCA1 P1812A Likely Oncogenic Likely Loss-of-function 15172985, 17020472 -BRCA1 A1789T Oncogenic Loss-of-function 23867111, 18680205 -BRCA1 G1738E Likely Oncogenic Loss-of-function 15172985, 10811118, 20516115, 17308087, 11157798 -BRCA1 R1835P Likely Oncogenic Likely Loss-of-function 20516115 -BRCA1 D1851E Likely Neutral Likely Neutral 20516115 -BRCA1 L1764P Likely Oncogenic Loss-of-function 15172985, 23867111, 20516115, 17308087 -BRCA1 E1735K Inconclusive Inconclusive 15172985, 23867111, 9809041 -BRCA1 E1682V Likely Neutral Likely Neutral 20516115 -BRCA1 E1346K Likely Neutral Likely Neutral 23867111 -BRAF V600K Oncogenic Gain-of-function 16273091, 22663011, 12068308, 25265492, 24508103, 25287827, 25399551, 15035987 Planchard et al. Abstract# 8009, ASCO 2013 http://meetinglibrary.asco.org/content/112427-132 -BRAF K601Q Likely Oncogenic Gain-of-function 19206169 -BRAF D594A Likely Oncogenic Gain-of-function 14678966, 20141835, 15035987 -BRAF G469E Likely Oncogenic Likely Gain-of-function 15150094, 22510884, 15035987, 16439621 -BRAF V600_K601delinsE Oncogenic Gain-of-function 26045855, 23833300 -BRAF G478C Likely Neutral Loss-of-function 22926515 -BRAF FAM131B-BRAF Fusion Likely Oncogenic Gain-of-function 15630448, 21424530 -BRAF L597S Likely Oncogenic Likely Gain-of-function 22798288, 26643848 -BRAF G464R Likely Oncogenic Gain-of-function 15046639 -BRAF Q201H Inconclusive Inconclusive 18060073 -BRAF D594Y Likely Oncogenic Likely Gain-of-function 23833300, 20141835, 16439621 -BRAF L485_Q494del Likely Oncogenic Likely Gain-of-function 26732095 -BRAF A728V Likely Oncogenic Gain-of-function 15035987 -BRAF W531C Likely Neutral Likely Neutral 19206169 -BRAF T599I Likely Oncogenic Gain-of-function 15035987 -BRAF L485_P490delinsF Likely Oncogenic Likely Gain-of-function 26732095 -BRAF F595L Likely Oncogenic Gain-of-function 15150094, 15035987 -BRAF K601N Likely Oncogenic Gain-of-function 24270325, 26343582 -BRAF D594G Likely Oncogenic Likely Gain-of-function 23833300, 18794803, 20141835, 16439621 -BRAF L485_P490del Oncogenic Gain-of-function 26732095 -BRAF R671Q Likely Oncogenic Likely Gain-of-function 28174173 -BRAF G466R Likely Oncogenic Likely Gain-of-function 16364920, 15046639, 15035987 -BRAF D594E Likely Oncogenic Gain-of-function 20978199 Noeparast et al. Abstract# 11091, ASCO 2015 http://meeting.ascopubs.org/cgi/content/abstract/33/15_suppl/11091 -BRAF G596R Likely Oncogenic Gain-of-function 14678966, 16364920, 15035987 -BRAF T599_V600insEAT Likely Oncogenic Likely Gain-of-function 16501605 -BRAF T488_P492del Likely Oncogenic Likely Gain-of-function 26732095 -BRAF T599_V600insETT Likely Oncogenic Likely Gain-of-function 16501605 -BRAF L505H Oncogenic Gain-of-function 25515853, 24112705, 24283590 -BRAF T599insTT Oncogenic Gain-of-function 21190184 -BRAF D287H Likely Oncogenic Likely Gain-of-function 26343582 -BRAF I463S Likely Neutral Likely Neutral 15150094, 15035987 -BRAF K601E Likely Oncogenic Gain-of-function 22798288, 24583796, 24933606, 26643848, 23248257, 15035987 -BRAF D594V Likely Oncogenic Gain-of-function 14678966, 19376813, 15035987, 16439621 -BRAF K483M Likely Oncogenic Likely Gain-of-function 19376813, 23533272, 15035987, 27025703 -BRAF T599dup Oncogenic Gain-of-function 23833300, 21190184, 19363522 -BRAF G464E Likely Neutral Likely Neutral 15150094, 20141835, 15035987 -BRAF T529N Likely Neutral Likely Neutral 15573099, 20538618 -BRAF S467A Likely Oncogenic Gain-of-function 19376813, 16439621 -BRAF T599R Oncogenic Gain-of-function 25120313, 19206169 -BRAF V600M Oncogenic Gain-of-function 23463675, 16273091, 12068308, 15035987, 25382067 -BRAF L597R Likely Oncogenic Likely Gain-of-function 22798288, 26643848 -BRAF V600D_K601insFGLAT Oncogenic Gain-of-function 17297294 -BRAF S151A Likely Oncogenic Likely Gain-of-function 21478863 -BRAF N581S Likely Oncogenic Likely Gain-of-function 15035987 -BRAF R462I Likely Neutral Neutral 15150094, 15035987 -BRAF SND1-BRAF Fusion Oncogenic Gain-of-function 25266736, 25985019, 22745804, 24345920 -BRAF F468C Oncogenic Gain-of-function 15150094 -BRAF E501G Likely Neutral Likely Neutral 16474404, 16439621 -BRAF Y472C Likely Oncogenic Gain-of-function 22649091 -BRAF G469del Likely Oncogenic Likely Gain-of-function 23833300 -BRAF TRIM24-BRAF Fusion Likely Oncogenic Gain-of-function 15630448, 24345920 -BRAF p61BRAF Oncogenic Gain-of-function 22113612 -BRAF D594N Likely Oncogenic Gain-of-function 22798288 Noeparast et al. Abstract# 11091, ASCO 2015 http://meeting.ascopubs.org/cgi/content/abstract/33/15_suppl/11091 -BRAF Q257R Likely Oncogenic Gain-of-function 19376813, 16474404, 16439621 -BRAF V600D Oncogenic Gain-of-function 23317446, 20551065, 16273091, 12068308, 15035987 -BRAF A598V Likely Oncogenic Gain-of-function 19200582 -BRAF MKRN1-BRAF Fusion Likely Oncogenic Likely Gain-of-function 18974108, 26314551, 15630448, 23817572 -BRAF R506_K507insVLR Likely Oncogenic Gain-of-function 23817572 -BRAF L597Q Likely Oncogenic Gain-of-function 26343582, 22798288, 26643848 -BRAF L485F Likely Oncogenic Gain-of-function 16474404, 16439621 -BRAF G464V Oncogenic Gain-of-function 15150094, 12068308, 15035987 -BRAF KIAA1549-BRAF Fusion Oncogenic Gain-of-function 18974108, 23533272, 24345920 -BRAF V600R Oncogenic Gain-of-function 16273091, 12068308, 23473613, 15035987, 23490649 -BRAF L485_P490delinsY Likely Oncogenic Likely Gain-of-function 26732095 -BRAF AGK-BRAF Fusion Oncogenic Gain-of-function 26314551, 23890088, 24135138 -BRAF G469V Likely Oncogenic Likely Gain-of-function 25870796, 23401075 -BRAF G469R Likely Oncogenic Gain-of-function 26150740, 24920063, 16096377, 26343582, 26619011 -BRAF T529I Likely Neutral Likely Neutral 15573099, 20538618 -BRAF E275K Likely Oncogenic Likely Gain-of-function 19206169 -BRAF CUL1-BRAF Fusion Likely Oncogenic Likely Gain-of-function 25985019, 22745804, 15630448, 26324360 -BRAF Fusions Likely Oncogenic Likely Gain-of-function 18974108, 26314551, 25985019, 23890088, 22745804, 15630448, 26324360, 21424530, 24345920 -BRAF T599_V600insV Oncogenic Gain-of-function 16501605 -BRAF A598T Likely Neutral Loss-of-function 26619011, 22926515 -BRAF V600G Likely Oncogenic Gain-of-function 20735442, 16273091, 12068308, 26287849, 15035987 -BRAF G469L Likely Oncogenic Likely Gain-of-function 24920063, 24035431 -BRAF AKAP9-BRAF Fusion Oncogenic Gain-of-function 15630448 -BRAF A246P Likely Oncogenic Gain-of-function 16474404 -BRAF V487_P492delinsA Likely Oncogenic Likely Gain-of-function 26732095 -BRAF T241P Likely Oncogenic Likely Gain-of-function 19206169 -BRAF V471F Oncogenic Gain-of-function 25348715 -BRAF G596V Likely Oncogenic Likely Gain-of-function 19376813, 16439621 -BRAF PAPSS1-BRAF Fusion Likely Oncogenic Gain-of-function 15630448, 24345920 -BRAF E501K Inconclusive Inconclusive 17603482, 16474404 -BRAF N486_P490del Likely Oncogenic Likely Gain-of-function 26732095, 18060073 -BRAF G466A Likely Oncogenic Gain-of-function 17724477, 15035987 -BRAF P490_Q494del Likely Oncogenic Likely Gain-of-function 26732095 -BRAF R509H Likely Neutral Loss-of-function 20179705 -BRAF V600delinsYM Oncogenic Gain-of-function 22752848 -BRAF N581Y Likely Oncogenic Likely Gain-of-function 19474002, 26084293, 19276360, 15035987 -BRAF E586K Likely Oncogenic Gain-of-function 15035987 -BRAF L584F Inconclusive Inconclusive 23658559 -BRAF I326V Likely Neutral Likely Neutral 17603482 -BRAF N581D Likely Oncogenic Likely Gain-of-function 16474404 -BRAF K483E Likely Oncogenic Likely Gain-of-function 27799065, 23533272, 15035987 -BRAF K499E Likely Oncogenic Gain-of-function 16474404, 16439621 -BRAF R462E Likely Oncogenic Likely Gain-of-function 25155755 -BRAF G596C Likely Oncogenic Gain-of-function Noeparast et al. Abstract# 11091, ASCO 2015 http://meeting.ascopubs.org/cgi/content/abstract/33/15_suppl/11091 -BRAF Amplification Oncogenic Gain-of-function 15467732, 24055054, 25618114, 22395615, 21098728 -BRAF G469A Oncogenic Gain-of-function 23833300, 12068308, 22510884, 15035987, 22773810, 16439621 -BRAF V600E Oncogenic Gain-of-function 20179705, 16273091, 23153539, 12068308, 15035987 -BRAF T529M Likely Neutral Likely Neutral 15573099, 20538618 -BRAF L597V Oncogenic Gain-of-function 26343582, 12068308, 26643848, 15035987 -BRAF G466E Likely Oncogenic Gain-of-function 16364920, 15035987, 24446311 -BRAF G466V Likely Oncogenic Gain-of-function 22649091, 24202393, 16364920, 15035987, 16439621 -BRCA2 A2351G Inconclusive Inconclusive 18824701 -BRCA2 S2483N Inconclusive Inconclusive 18824701 -BRCA2 R2520Q Likely Neutral Likely Neutral 18451181 -BRCA2 I1349T Inconclusive Inconclusive 17924331 -BRCA2 K2729N Likely Neutral Likely Neutral 17924331, 18451181 -BRCA2 D806H Inconclusive Inconclusive 17924331 -BRCA2 T2515I Inconclusive Inconclusive 18375895 -BRCA2 K2472T Inconclusive Inconclusive 18375895 -BRCA2 A75P Inconclusive Inconclusive 17924331 -BRCA2 R2888C Inconclusive Inconclusive 17924331 -BRCA2 R2304C Inconclusive Inconclusive 18824701 -BRCA2 R3052W Likely Oncogenic Likely Loss-of-function 18451181 -BRCA2 N1102Y Inconclusive Inconclusive 17924331 -BRCA2 M784V Inconclusive Inconclusive 18824701 -BRCA2 R2418G Inconclusive Inconclusive 18824701 -BRCA2 N2113S Inconclusive Inconclusive 17924331 -BRCA2 K607T Inconclusive Inconclusive 18375895 -BRCA2 V1643A Inconclusive Inconclusive 18824701 -BRCA2 A2643G Likely Neutral Likely Neutral 18451181 -BRCA2 L929S Inconclusive Inconclusive 18824701 -BRCA2 S1670A Inconclusive Inconclusive 18375895 -BRCA2 R2659K Likely Oncogenic Loss-of-function 17924331, 18451181, 12624152 -BRCA2 R1190W Inconclusive Inconclusive 17924331 -BRCA2 T2681R Inconclusive Inconclusive 18824701 -BRCA2 E2856A Likely Neutral Likely Neutral 16489001, 18824701 -BRCA2 T2250A Inconclusive Inconclusive 17924331 -BRCA2 N372H Likely Neutral Likely Neutral 18451181 -BRCA2 S206C Likely Oncogenic Likely Loss-of-function 22962691 -BRCA2 N517S Inconclusive Inconclusive 18824701 -BRCA2 E2663V Likely Oncogenic Likely Loss-of-function 17924331, 16489001, 18451181 -BRCA2 R2318Q Inconclusive Inconclusive 16489001 -BRCA2 D3095E Likely Oncogenic Likely Loss-of-function 17924331, 18451181 -BRCA2 G1771D Inconclusive Inconclusive 17924331 -BRCA2 R2784W Likely Oncogenic Likely Loss-of-function 18451181 -BRCA2 D935N Inconclusive Inconclusive 18375895 -BRCA2 P168T Inconclusive Inconclusive 17924331 -BRCA2 P1819S Likely Neutral Likely Neutral 17924331, 18824701 -BRCA2 H1966Y Inconclusive Inconclusive 18824701 -BRCA2 L2865V Likely Neutral Likely Neutral 18451181 -BRCA2 R2502C Inconclusive Inconclusive 17924331 -BRCA2 R174C Likely Oncogenic Likely Loss-of-function 22962691 -BRCA2 N2436I Inconclusive Inconclusive 17924331 -BRCA2 R2842H Inconclusive Inconclusive 17924331 -BRCA2 K1690N Inconclusive Inconclusive 17924331 -BRCA2 F1524V Inconclusive Inconclusive 17924331 -BRCA2 L2106P Inconclusive Inconclusive 18824701 -BRCA2 H1918Y Inconclusive Inconclusive 17924331 -BRCA2 D1352Y Inconclusive Inconclusive 18824701 -BRCA2 C1265S Inconclusive Inconclusive 16489001 -BRCA2 D1280V Inconclusive Inconclusive 17924331 -BRCA2 K513R Likely Neutral Likely Neutral 17924331, 18375895 -BRCA2 Y42C Likely Neutral Likely Neutral 16489001, 18451181, 18824701, 15290653 -BRCA2 S196N Likely Oncogenic Likely Loss-of-function 22962691 -BRCA2 D3170G Inconclusive Inconclusive 17924331 -BRCA2 G173C Likely Oncogenic Likely Loss-of-function 22962691 -BRCA2 A2770T Inconclusive Inconclusive 16489001 -BRCA2 I2285V Likely Neutral Likely Neutral 17924331, 18824701 -BRCA2 V211I Likely Oncogenic Likely Loss-of-function 19179552, 23451180, 22962691 -BRCA2 G2274V Inconclusive Inconclusive 16489001 -BRCA2 L2647P Likely Oncogenic Likely Loss-of-function 18451181 -BRCA2 D191G Likely Oncogenic Likely Loss-of-function 22962691 -BRCA2 C554W Inconclusive Inconclusive 17924331 -BRCA2 R2602T Likely Oncogenic Likely Loss-of-function 18424508, 22505045 -BRCA2 A1170V Inconclusive Inconclusive 18824701 -BRCA2 T3211K Inconclusive Inconclusive 18824701 -BRCA2 D1420Y Inconclusive Inconclusive 18824701 -BRCA2 R3052Q Inconclusive Inconclusive 17924331 -BRCA2 L1904V Inconclusive Inconclusive 17924331 -BRCA2 R2842C Likely Oncogenic Likely Loss-of-function 23108138 -BRCA2 W2626C Inconclusive Inconclusive 17924331 -BRCA2 T630I Inconclusive Inconclusive 17924331 -BRCA2 G2748D Likely Oncogenic Likely Loss-of-function 17924331, 18451181 -BRCA2 N56T Inconclusive Inconclusive 17924331 -BRCA2 K1434I Inconclusive Inconclusive 18824701 -BRCA2 N588D Inconclusive Inconclusive 18824701 -BRCA2 N1878K Inconclusive Inconclusive 18824701 -BRCA2 I2627F Likely Oncogenic Likely Loss-of-function 17924331, 18451181 -BRCA2 P655R Inconclusive Inconclusive 18824701, 15290653 -BRCA2 C1365Y Inconclusive Inconclusive 17924331 -BRCA2 M2676T Inconclusive Inconclusive 18824701 -BRCA2 V3079I Inconclusive Inconclusive 17924331 -BRCA2 D2723G Likely Oncogenic Likely Loss-of-function 17924331, 18451181 -BRCA2 D2723H Likely Oncogenic Likely Loss-of-function 16489001, 18451181, 15290653 -BRCA2 V894I Inconclusive Inconclusive 17924331 -BRCA2 C3198R Inconclusive Inconclusive 17924331 -BRCA2 T2722R Inconclusive Inconclusive 17924331 -BRCA2 G602R Inconclusive Inconclusive 17924331 -BRCA2 S1172L Likely Neutral Likely Neutral 17924331, 18375895, 18824701 -BRCA2 A2717S Inconclusive Inconclusive 18375895 -BRCA2 N1228D Inconclusive Inconclusive 17924331 -BRCA2 T3349A Inconclusive Inconclusive 17924331 -BRCA2 T582P Inconclusive Inconclusive 17924331 -BRCA2 R2502H Inconclusive Inconclusive 18824701 -BRCA2 P375S Inconclusive Inconclusive 17924331 -BRCA2 Q2858R Inconclusive Inconclusive 18375895 -BRCA2 Deletion Oncogenic Loss-of-function 12483515, 18501021, 27452521, 11239455, 22193408, 16199546 -BRCA2 S326R Inconclusive Inconclusive 18824701 -BRCA2 V2969M Inconclusive Inconclusive 17924331 -BRCA2 D2723A Likely Oncogenic Likely Loss-of-function 18451181 -BRCA2 S1733F Inconclusive Inconclusive 17924331 -BRCA2 Y3098H Inconclusive Inconclusive 17924331 -BRCA2 S869L Inconclusive Inconclusive 16489001 -BRCA2 V1306I Inconclusive Inconclusive 17924331 -BRCA2 S384F Likely Neutral Likely Neutral 16489001, 18824701 -BRCA2 V2908G Likely Neutral Likely Neutral 17924331, 18451181 -BRCA2 L209F Likely Neutral Likely Neutral 22962691 -BRCA2 R2973C Likely Neutral Likely Neutral 17924331, 18451181, 18824701 -BRCA2 T1354M Inconclusive Inconclusive 17924331 -BRCA2 D2312V Inconclusive Inconclusive 17924331 -BRCA2 I1929V Inconclusive Inconclusive 17924331 -BRCA2 L2721H Inconclusive Inconclusive 18824701 -BRCA2 H2074N Inconclusive Inconclusive 17924331 -BRCA2 L2396F Inconclusive Inconclusive 17924331 -BRCA2 Y3092C Inconclusive Inconclusive 17924331 -BRCA2 Q1396R Inconclusive Inconclusive 17924331 -BRCA2 Truncating Mutations Likely Oncogenic Likely Loss-of-function 20878484, 24312913, 11239455, 22193408, 10570174 -BRCA2 S2670L Likely Neutral Likely Neutral 16489001 -BRCA2 N987I Inconclusive Inconclusive 18824701 -BRCA2 Q2384K Inconclusive Inconclusive 17924331 -BRCA2 S142I Likely Oncogenic Likely Loss-of-function 21638052 -BRCA2 E3002K Likely Oncogenic Likely Loss-of-function 21947752, 23108138, 20694749 -BRCA2 K2950N Likely Neutral Likely Neutral 17924331, 18375895 -BRCA2 L1019V Inconclusive Inconclusive 17924331 -BRCA2 R18H Inconclusive Inconclusive 18375895 -BRCA2 D2665G Likely Neutral Likely Neutral 17924331, 16489001 -BRCA2 R2336P Likely Oncogenic Likely Loss-of-function 22505045, 9150172 -BRCA2 K2411T Inconclusive Inconclusive 17924331 -BRCA2 R2659T Likely Oncogenic Likely Loss-of-function 18451181 -BRCA2 N2048I Inconclusive Inconclusive 17924331 -BRCA2 N2829R Likely Oncogenic Likely Loss-of-function 22505045 -BRCA2 N319T Likely Neutral Likely Neutral 18451181 -BRCA2 E462G Likely Neutral Likely Neutral 17924331, 18451181 -BRCA2 G1529R Inconclusive Inconclusive 17924331 -BRCA2 S1424C Inconclusive Inconclusive 18824701 -BRCA2 I2675V Likely Oncogenic Likely Loss-of-function 18424508 -BRCA2 R2108H Inconclusive Inconclusive 17924331 -BRCA2 R2336H Likely Oncogenic Loss-of-function 17924331, 18451181, 18489799 -BRCA2 G1194D Inconclusive Inconclusive 17924331 -BRCA2 L2653P Likely Oncogenic Likely Loss-of-function 17924331, 18451181 -NF2 Truncating Mutations Likely Oncogenic Likely Loss-of-function 19545378, 8755919, 22825583, 9643284 -NF2 Q324L Likely Neutral Likely Neutral 11448944 -NF2 A211D Likely Oncogenic Likely Loss-of-function 21383154, 20178741 -NF2 L535P Likely Oncogenic Likely Loss-of-function 21383154, 20178741, 10712203, 11448944 -NF2 L46R Likely Oncogenic Likely Loss-of-function 21383154, 20178741 -NF2 L64P Likely Oncogenic Likely Loss-of-function 20178741, 11448944 -NF2 T352M Likely Neutral Likely Neutral 10712203, 11448944 -NF2 K79E Likely Oncogenic Likely Loss-of-function 10712203, 11448944 -NF2 K413E Inconclusive Inconclusive 21383154, 11448944 -NF2 E106G Likely Oncogenic Likely Loss-of-function 11448944 -NF2 Q538P Likely Oncogenic Likely Loss-of-function 11448944 -NF2 Deletion Likely Oncogenic Likely Loss-of-function 24726726, 15645494, 19451229, 22825583, 9643284 -PAX8 PAX8-PPAR? Fusion Oncogenic Gain-of-function 17131411, 10958784 -NFE2L2 W24S Likely Oncogenic Gain-of-function 24142871, 18757741, 1875774 -NFE2L2 D77H Likely Oncogenic Likely Gain-of-function 16888629, 26619011 -NFE2L2 E82V Likely Oncogenic Likely Gain-of-function 12167159 -NFE2L2 E79K Likely Oncogenic Gain-of-function 24142871, 18757741, 1875774 -NFE2L2 G31R Oncogenic Gain-of-function 27147599 -NFE2L2 G31A Oncogenic Gain-of-function 27147599 -NFE2L2 D29N Likely Oncogenic Gain-of-function 24142871, 18757741, 1875774 -NFE2L2 G81S Likely Oncogenic Gain-of-function 24142871, 18757741, 1875774 -NFE2L2 I28T Likely Oncogenic Gain-of-function 24142871, 18757741, 1875774 -NFE2L2 T80A Likely Oncogenic Gain-of-function 24142871, 18757741, 1875774 -NFE2L2 E82G Likely Oncogenic Gain-of-function 23365135 -NFE2L2 D29H Likely Oncogenic Gain-of-function 24142871, 18757741, 1875774 -NFE2L2 W24C Likely Oncogenic Gain-of-function 24142871, 18757741, 1875774 -NFE2L2 G81D Likely Oncogenic Gain-of-function 24142871, 18757741, 1875774 -NFE2L2 E79Q Likely Oncogenic Gain-of-function 24142871, 18757741, 1875774 -NFE2L2 G31V Oncogenic Gain-of-function 27147599 -NFE2L2 E82D Likely Oncogenic Likely Gain-of-function 24130096, 18757741 -NFE2L2 V32G Likely Oncogenic Gain-of-function 24142871, 18757741, 1875774 -NFE2L2 T80R Likely Oncogenic Gain-of-function 24142871, 18757741, 1875774 -NFE2L2 W24R Likely Oncogenic Gain-of-function 24142871, 18757741, 1875774 -NFE2L2 T80K Oncogenic Gain-of-function 24130096, 27147599, 18757741 -NFE2L2 D29Y Likely Oncogenic Gain-of-function 24142871, 18757741, 1875774 -NFE2L2 G81R Likely Oncogenic Gain-of-function 24142871, 18757741, 1875774 -NFE2L2 L30F Likely Oncogenic Gain-of-function 24142871, 18757741, 1875774 -GLI1 R380A Likely Oncogenic Likely Loss-of-function 25476449 -GLI1 Amplification Oncogenic Gain-of-function 3563490, 1825351 -FUBP1 Truncating Mutations Likely Oncogenic Likely Loss-of-function 22072542, 22588899, 21817013, 24117486 -BTK C481S Likely Oncogenic Gain-of-function 25189416, 24869598 -BTK R544S Likely Oncogenic Likely Gain-of-function 20052711, 20826165 -BTK Y551F Likely Neutral Loss-of-function 20052711, 9188445, 20826165 -NFKBIA M37K Likely Neutral Likely Gain-of-function 23708964 -NFKBIA S36Y Likely Neutral Likely Gain-of-function 23864385 -NFKBIA E14* Likely Neutral Gain-of-function 18412279 -NFKBIA S32I Likely Neutral Gain-of-function 14523047 -GNA11 R183C Oncogenic Gain-of-function 21083380 -GNA11 Q209L Oncogenic Gain-of-function 21083380 -KDR C482R Likely Oncogenic Likely Gain-of-function 18931684, 25411163, 21712447 -KDR Q472H Likely Oncogenic Likely Gain-of-function 24793135, 24599305, 21712447 Mockus et al. Abstract# 73, AACR 2015 http://cancerres.aacrjournals.org/content/75/15_Supplement/73 -KDR Amplification Oncogenic Gain-of-function 11114740, 26578684 -KDR A1065T Likely Oncogenic Gain-of-function 19723655 -KDR D717V Oncogenic Gain-of-function 19723655 -KDR R961W Inconclusive Inconclusive 27004155 -KDR T771R Inconclusive Inconclusive 26422291, 19723655 -BCL10 Truncating Mutations Likely Oncogenic Likely Loss-of-function 10319863, 9989495 -BCL10 Deletion Likely Oncogenic Likely Loss-of-function 10319863, 9989495, 10845924 -GNAQ R183Q Likely Oncogenic Likely Gain-of-function 22236444 -GNAQ Q209L Oncogenic Gain-of-function 19078957, 1328859, 21083380 -GNAS R201H Oncogenic Gain-of-function 26257060, 24498386 -GNAS Q227R Likely Oncogenic Likely Gain-of-function 2549426 -GNAS R201C Oncogenic Gain-of-function 25288233, 20531296 -GNAS R844H Oncogenic Gain-of-function 15148396, 19423757 -GNAS Q227L Likely Oncogenic Likely Gain-of-function 2549426 -MGA Deletion Likely Oncogenic Likely Loss-of-function 10601024 -MGA Truncating Mutations Likely Oncogenic Likely Loss-of-function 23039309 -KIT W557_V560del Likely Oncogenic Likely Gain-of-function 23775962, 18955458 -KIT N822Y Likely Oncogenic Likely Gain-of-function 21689725, 18724244 -KIT Y570H Likely Oncogenic Likely Gain-of-function 21642685 -KIT A504_Y505ins Likely Oncogenic Likely Gain-of-function 16551858 -KIT Amplification Likely Oncogenic Likely Gain-of-function 15650049, 18506689, 16166280, 21523721, 19779861, 15869870, 24868028, 17189383 -KIT P577_W582delinsPYD Likely Oncogenic Likely Gain-of-function 23775962 -KIT D816E Likely Oncogenic Likely Gain-of-function 16551858, 25239608, 16397263 -KIT D52N Likely Oncogenic Likely Gain-of-function 9168438 -KIT V560G Oncogenic Gain-of-function 15790786, 16434489, 14645423, 16954519, 16397263 -KIT Exon 9 mutations Oncogenic Gain-of-function 18235121, 12181401, 23076159, 17662946, 24061512, 18955458, 16098458, 15451219 -KIT V559D Oncogenic Gain-of-function 15790786, 17372901, 18980976, 18955458, 16954519, 25605837, 15930355, 17699867, 9438854 -KIT D820Y Likely Oncogenic Likely Switch-of-function 14977822, 16551858, 18623623, 23840364, 25239608, 22614970, 18955458, 15930355, 17699867 -KIT P551_M552del Likely Oncogenic Likely Gain-of-function 18955458 -KIT K558_E562del Likely Oncogenic Likely Gain-of-function 25735500 -KIT P551_E554del Oncogenic Gain-of-function 25239608, 16954519 -KIT Exon 11 mutations Oncogenic Gain-of-function 18235121, 17372901, 25079768, 12181401, 17046465, 19282169, 25641662, 16098458, 15451219, 23177515, 19536093 -KIT K558_V559del Likely Oncogenic Likely Gain-of-function 18955458, 16954519 -KIT N505I Oncogenic Gain-of-function 24317392 -KIT W557G Likely Oncogenic Likely Gain-of-function 10224103, 25079768, 15342366 -KIT R634W Oncogenic Gain-of-function 15790786 -KIT W557_K558del Oncogenic Gain-of-function 14645423, 25239608, 16954519, 15930355, 17699867 -KIT D419del Likely Oncogenic Gain-of-function 16143141, 23599150 -KIT T417_D419delinsRG Oncogenic Gain-of-function 15790786 -KIT V569_L576del Likely Oncogenic Likely Gain-of-function 16551858, 15930355 -KIT L576P Oncogenic Gain-of-function 22357254, 17372901, 26264378, 18980976, 25605837, 15930355, 19671763, 22068222, 23775962, 21642685, 25695690, 18955458, 16954519 -KIT V559I Likely Oncogenic Gain-of-function 17259998 -KIT T670I Oncogenic Gain-of-function 16551858, 17545544, 23840364, 16954519, 17699867 -KIT N822K Oncogenic Gain-of-function 15790786, 23840364, 21482694, 24490049, 21642685, 25695690, 22614970, 16954519, 26316776, 17699867 -KIT Y553N Likely Oncogenic Likely Gain-of-function 21969494, 22357254 -KIT D820G Likely Oncogenic Likely Gain-of-function 16551858, 18623623, 23840364, 18955458, 16954519, 21456006 -KIT D816G Oncogenic Gain-of-function 25239608 -KIT K558delinsNP Oncogenic Gain-of-function 11526490, 25239608, 18955458, 16954519 -KIT T574insTQLPYD Likely Oncogenic Likely Gain-of-function 15930355 -KIT N822I Oncogenic Gain-of-function 21689725 -KIT W557R Likely Oncogenic Gain-of-function 14977822, 10224103, 19018266, 22357254, 21953054, 25079768, 21325067, 18980976, 21906875, 21642685, 20859122, 12888812 -KIT N463S Likely Oncogenic Likely Gain-of-function 21642685 -KIT C809G Likely Oncogenic Likely Gain-of-function 17139461, 18955458, 16954519 -KIT K550_K558del Oncogenic Gain-of-function 16954519, 9438854 -KIT D816F Oncogenic Gain-of-function 16397263 -KIT S501_A502dup Likely Oncogenic Gain-of-function 22324351 -KIT I653T Likely Oncogenic Likely Gain-of-function 21642685 -KIT E554_I571del Likely Oncogenic Likely Gain-of-function 16954519 -KIT V560E Likely Oncogenic Likely Gain-of-function 21690468, 22350270, 25239608 -KIT S709F Likely Oncogenic Likely Gain-of-function 16551858 -KIT P577_D579del Likely Oncogenic Likely Gain-of-function 22357254 -KIT D60N Likely Oncogenic Gain-of-function 24211109, 16226710 -KIT D572A Likely Oncogenic Gain-of-function 19865100 -KIT D816N Likely Oncogenic Gain-of-function 11369651 -KIT S476I Likely Oncogenic Gain-of-function 19865100 -KIT V559G Oncogenic Gain-of-function 23348204, 12569358 -KIT N564_Y578del Likely Oncogenic Likely Gain-of-function 16952044 -KIT T574_R588delinsL Likely Oncogenic Likely Gain-of-function 18955458 -KIT K550_W557del Oncogenic Gain-of-function 25239608 -KIT P551_V555del Oncogenic Gain-of-function 9438854 -KIT N822H Likely Oncogenic Gain-of-function 14645423, 18955458, 16954519 -KIT I563_L576del Likely Oncogenic Likely Gain-of-function 15930355 -KIT V559A Likely Oncogenic Likely Gain-of-function 15897563, 19812602, 16908931, 9438854 -KIT Y568_L576delinsVN Likely Oncogenic Likely Gain-of-function 18955458 -KIT D816A Likely Oncogenic Likely Gain-of-function 18955458, 16397263 -KIT V555_V559del Likely Oncogenic Gain-of-function 18955458, 15930355 -KIT L576del Likely Oncogenic Gain-of-function 19802003, 12717247 -KIT D820E Likely Oncogenic Likely Gain-of-function 19461405, 25886408, 15685537 -KIT K558N Likely Oncogenic Likely Gain-of-function 18980976 -KIT K550_V555delinsI Oncogenic Gain-of-function 9438854 -KIT C443Y Likely Oncogenic Gain-of-function 19865100 -KIT Y553_Q556del Likely Oncogenic Gain-of-function 15690055 -KIT D816Y Oncogenic Gain-of-function 15790786, 15167915, 16397263, 15725473 -KIT D579del Likely Oncogenic Likely Gain-of-function 24419427, 18955458 -KIT K509I Likely Oncogenic Gain-of-function 19865100 -KIT V654A Likely Oncogenic Gain-of-function 18623623, 23840364, 21642685, 18955458, 16954519, 16751810 -KIT Y418_D419del Likely Oncogenic Gain-of-function 22825855, 19603346, 16143141 -KIT V559_G565del Likely Oncogenic Likely Gain-of-function 16551858 -KIT V559C Likely Oncogenic Likely Gain-of-function 15897563, 21642685, 25695690, 9438854 -KIT A502_Y503dup Oncogenic Gain-of-function 22350270, 25239608, 18955458, 16954519, 21527588, 17699867 -KIT Q556_K558del Likely Oncogenic Likely Gain-of-function 19369884, 17372901, 25079768 -KIT V559_V560del Oncogenic Gain-of-function 16551858, 15790786, 16954519 -KIT F522C Likely Oncogenic Gain-of-function 15070706 -KIT H697Y Oncogenic Gain-of-function 19861435 -KIT D814V Oncogenic Gain-of-function 12569358 -KIT D816H Oncogenic Gain-of-function 18623623, 16956837, 18980976, 25304235, 25239608, 18955458, 16954519, 16397263 -KIT E490K Likely Oncogenic Likely Gain-of-function 22357254 -KIT E839K Likely Neutral Neutral 15790786 -KIT N655K Likely Oncogenic Likely Gain-of-function 17489795 -KIT P573_D579del Likely Oncogenic Gain-of-function 12569358, 9438854 -KIT K642E Likely Oncogenic Gain-of-function 24855380, 23940219, 11526490, 25695690, 25304235, 25239608, 14645423, 16954519 -KIT V555_L576del Likely Oncogenic Gain-of-function 23840364 -KIT V560del Oncogenic Gain-of-function 22357254, 16551858, 19861435, 15201427, 25605837 -KIT V560D Oncogenic Gain-of-function 23775962, 16551858, 23840364, 25239608, 18955458, 16954519, 25605837, 9438854 -KIT Y823D Oncogenic Gain-of-function 20633291, 22069175, 16551858, 18623623, 22301675, 18980976, 22089421, 18955458, 16954519, 15930355 -KIT E554_V559del Likely Oncogenic Likely Gain-of-function 18980976 -KIT M541L Likely Oncogenic Likely Gain-of-function 25015329, 21757432, 15790786, 20664593, 21498700, 18795925, 16307017 -KIT D820A Likely Oncogenic Likely Gain-of-function 23840364, 25239608, 18955458, 16954519 -KIT R796G Likely Neutral Loss-of-function 20824047 -KIT 550_592del Oncogenic Gain-of-function 18235121, 17372901, 25079768, 12181401, 15365079, 16098458, 15451219 -KIT V530I Oncogenic Gain-of-function 20339585, 16081693 -KIT W557_V559delinsC Likely Oncogenic Likely Gain-of-function 18955458 -KIT V559del Likely Oncogenic Gain-of-function 23993026, 15236194, 10485475, 16751810 -KIT V852I Likely Oncogenic Likely Gain-of-function 21642685 -KIT P838L Likely Oncogenic Likely Gain-of-function 21642685 -KIT Y578C Likely Oncogenic Gain-of-function 23567324 -KIT T417_D419delinsI Oncogenic Gain-of-function 15790786 -KIT D737N Inconclusive Inconclusive 26863566 -KIT P551_W557delinsL Likely Oncogenic Likely Gain-of-function 25239608 -KIT D816V Oncogenic Gain-of-function 15972446, 19193436, 7479840, 26002753, 16434489, 16397263, 15725473, 15790786, 17545544, 22301675, 16254134, 14645423, 16779792, 23659595, 23416972 -KIT M552_W557del Likely Oncogenic Likely Gain-of-function 16551858, 16954519 -KIT Y553_K558del Likely Oncogenic Likely Gain-of-function 16954519 -KIT E554_K558del Likely Oncogenic Likely Gain-of-function 18955458, 16954519, 15930355 -KIT A829P Likely Oncogenic Likely Gain-of-function 18623623, 18980976, 21642685, 25239608, 18955458 -KIT M552_K558del Likely Oncogenic Likely Gain-of-function 25239608 -KIT Exon 11 deletions Oncogenic Gain-of-function 18235121, 17372901, 25079768, 12181401, 15365079, 16098458, 15451219 -FGF19 Amplification Likely Oncogenic Likely Gain-of-function 24265351, 21397858, 22309595 -MED12 G44S Oncogenic Switch-of-function 24746821 -MED12 Exon 1 mutations Oncogenic Gain-of-function 24980722 -MED12 Deletion Likely Oncogenic Likely Loss-of-function 23178117 -MED12 L1224F Likely Oncogenic Likely Gain-of-function 12218053, 26619011, 17612495, 26383637 -MED12 Exon 2 mutations Oncogenic Likely Gain-of-function 23738515, 25038752, 23913526, 21868628 -MED12 G44D Oncogenic Switch-of-function 24746821 -NOTCH1 Deletion Likely Oncogenic Likely Gain-of-function 22077063, 23734977, 20852131 -NOTCH1 V1578del Likely Oncogenic Likely Gain-of-function 22056382, 24651013, 16618740, 25806268, 15472075, 16738328 -NOTCH1 L1574P Oncogenic Gain-of-function 22056382, 24651013, 16618740, 25806268, 15472075, 16738328 -NOTCH1 L1678P Likely Oncogenic Gain-of-function 22056382, 24651013, 16618740, 25806268, 16738328 -NOTCH1 I1718T Likely Oncogenic Gain-of-function 22056382, 24651013, 16618740, 25806268, 16738328 -NOTCH1 A1701P Likely Oncogenic Gain-of-function 22056382, 24651013, 16618740, 25806268, 16738328 -NOTCH1 P2415del Likely Oncogenic Likely Gain-of-function 24651013, 25564152, 21948802, 15472075 -NOTCH1 L1593P Likely Oncogenic Gain-of-function 22056382, 24651013, 16618740, 25806268, 16738328 -NOTCH1 MIR143-NOTCH1 Fusion Likely Oncogenic Likely Gain-of-function 23999936 -NOTCH1 Q2405Rfs*17 Likely Oncogenic Likely Gain-of-function 24651013, 25564152, 21948802, 15472075 -NOTCH1 L2429V Likely Oncogenic Likely Gain-of-function 24651013, 25564152, 21948802, 15472075 -NOTCH1 V1676D Likely Oncogenic Gain-of-function 22056382, 24651013, 16618740, 25806268, 16738328 -NOTCH1 P2417A Likely Oncogenic Likely Gain-of-function 24651013, 25564152, 21948802, 15472075 -NOTCH1 V1671I Likely Oncogenic Likely Gain-of-function 24651013, 25376516, 15472075, 19340001 -NOTCH1 R1608S Likely Neutral Likely Neutral 24651013, 16738328 -NOTCH1 L1596H Likely Oncogenic Gain-of-function 22056382, 24651013, 16618740, 25806268, 16738328 -NOTCH1 V1605del Likely Oncogenic Likely Gain-of-function 22056382, 24651013, 16618740, 25806268, 15472075, 16738328 -NOTCH1 I1680N Likely Oncogenic Gain-of-function 22056382, 24651013, 16618740, 25806268, 16738328 -NOTCH1 SEC16A1-NOTCH1 Fusion Oncogenic Gain-of-function 22101766 -NOTCH1 G2430A Likely Oncogenic Gain-of-function 20823234 -NOTCH1 Truncating Mutations in the PEST Domain Likely Oncogenic Likely Gain-of-function 22056382, 24651013, 16618740, 25564152, 21948802, 25806268, 15472075 -NOTCH1 Q2416* Likely Oncogenic Likely Gain-of-function 24651013, 25564152, 21948802, 15472075 -NOTCH1 F1592S Likely Oncogenic Gain-of-function 22056382, 24651013, 16618740, 25806268, 16738328 -NOTCH1 Truncating Mutations Upstream of Transactivation Domain Oncogenic Likely Loss-of-function 24651013, 22006338, 21798897, 21798893 -NOTCH1 V1576E Likely Oncogenic Gain-of-function 22056382, 24651013, 16618740, 25806268, 16738328 -NOTCH1 H2428Q Likely Oncogenic Likely Gain-of-function 24651013, 25564152, 21948802, 15472075 -NOTCH1 Fusions Likely Oncogenic Likely Gain-of-function 16688224, 22101766, 23033986 -NOTCH1 R1598P Likely Oncogenic Gain-of-function 22056382, 24651013, 16618740, 25806268, 16738328 -NOTCH1 L1600P Likely Oncogenic Gain-of-function 22056382, 24651013, 16618740, 25806268, 15472075, 16738328 -NOTCH1 P2412T Likely Oncogenic Likely Gain-of-function 24651013, 25564152, 21948802, 15472075 -NOTCH1 A2425T Likely Oncogenic Likely Gain-of-function 24651013, 25564152, 21948802, 15472075 -NOTCH1 I1616T Likely Oncogenic Gain-of-function 22056382, 24651013, 16618740, 25806268, 16738328 -NOTCH1 R1594Q Likely Oncogenic Loss-of-function 24651013, 22006338, 27228302 -NOTCH1 G2420C Likely Oncogenic Likely Gain-of-function 24651013, 25564152, 21948802, 15472075 -NOTCH1 I1616N Likely Oncogenic Gain-of-function 22056382, 24651013, 16618740, 25806268, 16738328 -NOTCH2 2010_2471trunc Likely Oncogenic Likely Gain-of-function 21378989 -NOTCH2 1_2009trunc Likely Oncogenic Likely Loss-of-function 22006338 -RAC1 P29S Oncogenic Gain-of-function 2546593, 22842228, 23284172, 25056119, 25465943 -RAC1 Q61R Likely Oncogenic Gain-of-function 26619011 -RAC1 C18Y Likely Oncogenic Gain-of-function 28115009 -RAC1 Amplification Likely Oncogenic Gain-of-function 24072884, 23474757 -RAC1 G12V Oncogenic Gain-of-function 23382236, 23284172 -RAC1 C157Y Likely Oncogenic Gain-of-function 23382236 -RAC1 P29L Oncogenic Gain-of-function 23382236 -DNMT3A R882C Likely Oncogenic Likely Gain-of-function 24656771, 27010239 -DNMT3A R882H Likely Oncogenic Likely Gain-of-function 22722925, 24167195, 24656771, 25416276, 27010239 -DNMT3A Truncating Mutations Likely Oncogenic Likely Loss-of-function 21067377, 25964253, 24614070 -DNMT3A Deletion Likely Oncogenic Likely Loss-of-function 21067377, 27636998 -DNMT3B DNMT3B7 Likely Oncogenic Likely Switch-of-function 20587527, 23315164, 25607950, 22815530, 17353906 -DNMT3B Amplification Likely Oncogenic Likely Gain-of-function 25470049, 22810696 -RAD21 Truncating Mutations Likely Oncogenic Likely Loss-of-function 28116354, 25006131 -RAD21 Deletion Likely Oncogenic Likely Loss-of-function 28116354, 25006131 -RAD51 Truncating Mutations Likely Oncogenic Likely Loss-of-function -RAD51C A126T Likely Neutral Neutral 21990120, 26261251, 20400964, 21980511 -RAD51C Truncating Mutations Likely Oncogenic Likely Loss-of-function 20400963, 20400964, 21616938 -RAD51C G264S Likely Neutral Neutral 21990120, 26261251, 20400964 -RAD51B HMGA2-RAD51B Fusion Likely Oncogenic Likely Switch-of-function 9892177, 26787895, 11450849 -RAD51D Truncating Mutations Likely Oncogenic Likely Loss-of-function 23372765, 21822267, 22986143 -KRAS G12C Oncogenic Gain-of-function 25705018, 24256730, 16051643, 26841430 -KRAS G12D Oncogenic Gain-of-function 17349581, 24300897, 19296721, 26037647, 11751631, 15093544, 20570890, 20147967 -KRAS A146V Likely Oncogenic Gain-of-function 3043178, 26841430 -KRAS G12V Oncogenic Gain-of-function 20516123, 20949621, 25359494, 20570890, 12957286, 20147967 -KRAS Wildtype Likely Neutral Neutral 22810696, 12506171 NCCN Colon 2.2017 https://www.nccn.org/professionals/physician_gls/pdf/colon.pdf -KRAS T74P Likely Oncogenic Gain-of-function 19075190 -KRAS G13C Oncogenic Gain-of-function 25705018, 21079152 -KRAS Q61R Oncogenic Gain-of-function 21993244, 25363767, 24651010, 25437878 -KRAS T58I Oncogenic Gain-of-function 20949621, 16474405, 18509354 -KRAS Y71H Oncogenic Gain-of-function 23059812 -KRAS Q22R Likely Oncogenic Likely Gain-of-function 20949621, 21263000 -KRAS A18D Oncogenic Gain-of-function 19490892 -KRAS G13D Oncogenic Gain-of-function 20978259, 26037647, 22722830, 20147967 -KRAS R164Q Inconclusive Inconclusive 26274561, 20147967 -KRAS P34R Oncogenic Gain-of-function 8995293, 17875937, 20949621, 16474405 -KRAS E62K Oncogenic Gain-of-function 27147599 -KRAS G60R Oncogenic Gain-of-function 20949621 -KRAS F156L Oncogenic Gain-of-function 20949621, 17601930, 7877967 -KRAS G12R Oncogenic Gain-of-function 24893629, 26037647, 21831957, 22722830 -KRAS Q61H Oncogenic Gain-of-function 25705018, 21993244, 24651010, 20147967 -KRAS K117N Oncogenic Gain-of-function 20570890, 20147967 -KRAS Y32S Likely Oncogenic Gain-of-function 11333268, 26841430 -KRAS A11_G12insGA Oncogenic Gain-of-function 24642870 -KRAS G12A Oncogenic Gain-of-function 26662311, 26037647, 25013473, 23182985 -KRAS F28L Oncogenic Gain-of-function 25600866, 20949621, 16474405 -KRAS L19F Oncogenic Gain-of-function 17150185, 20147967 -KRAS K147E Oncogenic Gain-of-function 23059812 -KRAS Y40A Inconclusive Inconclusive 11333268, 26841430 -KRAS G12S Oncogenic Gain-of-function 26184075, 25284075 -KRAS P34L Oncogenic Gain-of-function 17875937, 20949621 -KRAS V14I Oncogenic Gain-of-function 25359213, 20949621, 16474405 -KRAS Q22K Oncogenic Gain-of-function 23059812, 11095964, 20570890 -KRAS Y64A Oncogenic Gain-of-function 12628188, 26841430 -KRAS Q22E Oncogenic Gain-of-function 20949621, 21263000 -KRAS Amplification Likely Oncogenic Likely Gain-of-function 23099803, 24874471, 20841479, 23404247 -KRAS G60D Inconclusive Inconclusive 21632860 -KRAS G12F Likely Oncogenic Likely Gain-of-function 20871262 -KRAS A59G Oncogenic Gain-of-function 27147599, 1221964, 26841430 -KRAS D119N Likely Oncogenic Likely Gain-of-function 8552403, 11103938 -KRAS A146T Oncogenic Gain-of-function 19075190, 20570890, 20147967, 2403644 -KRAS E31K Likely Neutral Likely Neutral 20570890, 16483931 -KRAS Q25H Inconclusive Inconclusive 21375404 -KRAS G13E Likely Oncogenic Likely Gain-of-function 19453520, 26619011, 17503413, 19521964 -KRAS K5N Oncogenic Gain-of-function 17875937, 20949621, 25941399 -KRAS S65N Oncogenic Gain-of-function 8626650, 24798740 -KRAS Q61L Oncogenic Gain-of-function 21993244, 25363767, 24651010, 26854029, 25437878 -KRAS D153V Oncogenic Gain-of-function 17875937, 20949621, 16474405, 25941399 -KRAS G10dup Oncogenic Gain-of-function 8955068 -KRAS N116H Inconclusive Inconclusive 26841430 -NPM1 Deletion Likely Oncogenic Likely Loss-of-function 18212245, 19322210, 20877721, 16007073 -NPM1 Truncating Mutations Likely Oncogenic Likely Loss-of-function 19322210, 20877721 -RAF1 S257W Likely Oncogenic Gain-of-function 12077328, 7867061, 17603483 -RAF1 S257L Oncogenic Gain-of-function 12077328, 7867061, 24569458, 17603483 -RAF1 Fusions Likely Oncogenic Likely Gain-of-function 27810072, 19363522, 20526349, 23637631 -RAF1 I448V Oncogenic Gain-of-function 19357705 -RAF1 S259A Oncogenic Gain-of-function 24569458, 20679480 -RAF1 ESRP1-RAF1 Fusion Oncogenic Gain-of-function 20526349 -RAF1 S427G Oncogenic Gain-of-function 16585161, 19357705 -RAF1 S259F Oncogenic Gain-of-function 17603483, 20679480 -RAF1 P261L Likely Oncogenic Likely Gain-of-function 17603483, 20679480 -RAF1 Amplification Oncogenic Gain-of-function 11389083, 21215703, 16517112 Zehir A et al. Nature Medicine 2017 http://doi:10.1038/nm.4333 -RAF1 ATG7-RAF1 Fusion Likely Oncogenic Likely Gain-of-function 23637631 -RAF1 S259P Likely Oncogenic Gain-of-function 20679480 -RAF1 SRGAP3-RAF1 Fusion Oncogenic Gain-of-function 19363522 -RAB35 F161L Oncogenic Gain-of-function 26338797 -RAB35 A151T Oncogenic Gain-of-function 26338797 -HNF1A Truncating Mutations Likely Oncogenic Likely Loss-of-function 12574234, 18003757, 25793983 -HNF1A T196A Likely Neutral Neutral 21170474 -HNF1A Deletion Likely Oncogenic Likely Loss-of-function 12574234, 25793983 -HNF1A P291Qfs*51 Likely Oncogenic Likely Loss-of-function 12574234, 9313763, 16917892 -AKT3 Amplification Oncogenic Gain-of-function 17178867, 24138071, 18451171, 25737557, 15466193, 20647317 -AKT3 E17K Likely Oncogenic Gain-of-function 18813315 -AKT3 Fusions Likely Oncogenic Likely Gain-of-function 22722202 -AKT3 MAGI3-AKT3 Fusion Oncogenic Gain-of-function 22722202 -TCF3 N551K Likely Oncogenic Loss-of-function 24492847, 22885699 -TCF7L2 Truncating Mutations Likely Oncogenic Likely Loss-of-function 10919662, 16547505, 18478343, 18599616, 10485457 -RARA R276W Inconclusive Inconclusive 27148563, 23670176, 19865110, 11438209 -NRAS Q61R Oncogenic Gain-of-function 25277205, 21993244, 20194776, 23515407, 24651010, 19492075 -NRAS G12C Likely Oncogenic Likely Gain-of-function 21993244, 24651010 -NRAS Amplification Inconclusive Inconclusive 26266759, 25263998, 22876308 Zehir A et al. Nature Medicine, 2017 http://doi:10.1038/nm.4333 -NRAS G13D Oncogenic Gain-of-function 26037647, 21993244, 24651010, 22722830 -NRAS G12R Oncogenic Gain-of-function 21993244, 24651010 -NRAS Q61H Oncogenic Gain-of-function 21993244, 20194776, 23515407, 24651010 -NRAS G13V Likely Oncogenic Likely Gain-of-function 20371679, 21993244, 24651010 -NRAS Q61K Oncogenic Gain-of-function 25277205, 21993244, 20194776, 23515407, 24651010, 19492075 -NRAS Q61L Oncogenic Gain-of-function 25277205, 21993244, 20194776, 23515407, 24651010, 19492075 -NRAS T50I Likely Oncogenic Likely Gain-of-function 22817889, 19966803 -NRAS G12D Oncogenic Gain-of-function 21993244, 23687087, 24651010, 25252692, 18372904 -NRAS G12V Oncogenic Gain-of-function 18952898, 21993244, 21478863, 24651010 -NRAS G60E Likely Oncogenic Gain-of-function 19075190, 19966803, 10716188, 21263000 -NRAS T58I Likely Oncogenic Likely Gain-of-function 24265153, 16474405 -RASA1 Deletion Likely Oncogenic Likely Loss-of-function 2173144, 9121432, 9034330, 1689011 -RASA1 Y472H Likely Oncogenic Likely Loss-of-function 26993606 -RASA1 Truncating Mutations Likely Oncogenic Likely Loss-of-function 2173144, 9121432, 9034330, 1689011, 24038909 -RASA1 L481F Likely Oncogenic Likely Loss-of-function 26993606 -BCL2L11 Truncating Mutations Likely Oncogenic Likely Loss-of-function 24737648, 23382048, 26076815, 23559152, 21652541, 26001141, 23116058 -BCL2L11 Single Nucleotide Polymorphism Oncogenic Loss-of-function 24223824 -BCL2L11 Deletion Oncogenic Likely Loss-of-function 22426421, 26076815, 23559152, 23116058 -RB1 R661W Inconclusive Inconclusive 16449662, 7927327, 9420334, 1352883, 18677112 -RB1 Truncating Mutations Likely Oncogenic Likely Loss-of-function 25621664, 22293180, 22205104 -RB1 R621C Likely Oncogenic Likely Loss-of-function 20594292 -RB1 C706F Likely Oncogenic Likely Loss-of-function 18677112 -RB1 L607I Likely Oncogenic Likely Loss-of-function 20594292 -RB1 N480del Likely Neutral Likely Neutral 18677112 -RB1 R698W Likely Oncogenic Likely Loss-of-function 20594292 -RB1 Deletion Likely Oncogenic Likely Loss-of-function 16127685, 17854503, 23960888 -RB1 S567L Likely Oncogenic Likely Loss-of-function 10671068, 9420334 -RB1 C712R Likely Neutral Likely Neutral 18677112 -RB1 W563L Inconclusive Inconclusive 16269091, 10882758 -KDM5A Amplification Likely Oncogenic Likely Gain-of-function 22937203, 2293720 -NTRK1 TFG-NTRK1 Fusion Likely Oncogenic Gain-of-function 7565764, 9488046 -NTRK1 Fusions Likely Oncogenic Likely Gain-of-function 24162815 -NTRK1 NFASC-NTRK1 Fusion Oncogenic Gain-of-function 24647444 -NTRK1 TPM3-NTRK1 Fusion Oncogenic Gain-of-function 2869410, 2927393, 24962792 -NTRK1 S677N Likely Oncogenic Likely Gain-of-function 18270328 -NTRK1 BCAN-NTRK1 Fusion Likely Oncogenic Likely Gain-of-function 24647444 -NTRK1 V710A Likely Neutral Loss-of-function 27272783 -NTRK1 Delta-NTRK1 Fusion Oncogenic Gain-of-function 11073967 -NTRK1 LMNA-NTRK1 Fusion Oncogenic Gain-of-function 24445538 -NTRK1 Amplification Likely Oncogenic Gain-of-function 26496938 -NTRK1 TPR-NTRK1 Fusion Oncogenic Gain-of-function 9172002, 1532241, 7851906 -NTRK1 TRKAIII Splice Variant Oncogenic Gain-of-function 15488758 -NTRK1 MPRIP-NTRK1 Fusion Oncogenic Gain-of-function 24162815 -NTRK1 R342Q Likely Oncogenic Gain-of-function 1695324, 11313867, 23000897, 23636398, 22460905 -NTRK1 CD74-NTRK1 Fusion Oncogenic Gain-of-function 24162815 -NTRK1 CHTOP-NTRK1 Fusion Likely Oncogenic Likely Gain-of-function 24647444, 25384085 -NTRK1 R342W Likely Oncogenic Gain-of-function 1695324, 11313867, 23636398, 22460905 -NTRK2 M713I Likely Neutral Likely Loss-of-function 21242122 -NTRK2 Fusions Likely Oncogenic Likely Gain-of-function 26565381, 25204415, 26216294, 26884591, 24647444, 24445538, 26457764, 26797418, 24162815, 27843590, 26603524 -NTRK2 R734C Likely Neutral Likely Loss-of-function 21242122 -NTRK2 R715G Likely Neutral Likely Neutral 21242122 -NTRK3 Fusions Likely Oncogenic Likely Gain-of-function 26565381, 25204415, 26216294, 26884591, 27843950, 26457764, 26797418, 27148571, 26603524 -NTRK3 ETV6-NTRK3 Fusion Oncogenic Gain-of-function 10702799, 12450792 -NTRK3 G623R Likely Oncogenic Likely Gain-of-function 26884591 -NTRK3 CPEB1-NTRK3 Fusion Oncogenic Gain-of-function 24705251 -NTRK3 BTBD1-NTRK3 Fusion Oncogenic Gain-of-function 24705251 -DUSP4 Deletion Inconclusive Inconclusive 21317287, 19525976 -DDR2 Amplification Likely Oncogenic Likely Gain-of-function 24505276, 26362312, 28099935 -DDR2 L239R Oncogenic Gain-of-function 22328973, 23335507 -DDR2 L63V Oncogenic Gain-of-function 23822953, 22328973 -DDR2 G505S Likely Oncogenic Gain-of-function 23822953, 22328973 -DDR2 G774V Oncogenic Gain-of-function 22328973 -DDR2 T654I Inconclusive Inconclusive 24296828 -DDR2 G253C Oncogenic Gain-of-function 22328973, 23335507 -DDR2 T654M Inconclusive Inconclusive 22328973, 24296828 -DDR2 S768R Likely Oncogenic Likely Gain-of-function 22328973, 25173530 -DDR2 I638F Inconclusive Inconclusive 23822953, 22328973 -SOX17 Deletion Likely Oncogenic Likely Loss-of-function 17655922, 28237397, 24407731, 20716954, 17875931, 18413743, 19301122, 27738313, 21514720, 24153254, 27102016, 22846201 -SOX17 Truncating Mutations Likely Oncogenic Likely Loss-of-function -NSD1 NSD1-NUP98 Fusion Likely Oncogenic Likely Gain-of-function 11895789, 23630019 -NSD1 Fusions Likely Oncogenic Likely Gain-of-function 11895789, 23630019, 27889185 -CASP8 Truncating Mutations Likely Oncogenic Likely Loss-of-function 15531912, 19852930, 15705878, 12949717 -CASP8 G325A Likely Oncogenic Gain-of-function 23659359 -CASP8 Promoter Hypermethylation Likely Oncogenic Loss-of-function 16397500, 10969767, 11593392 -CASP8 CASP8L Likely Oncogenic Loss-of-function 12010809, 10860845, 15735742, 16374545 -CASP8 Deletion Likely Oncogenic Likely Loss-of-function 15531912, 12055196, 15705878 -CASP8 C248T Likely Neutral Neutral 12353035 -RET C618R Oncogenic Gain-of-function 9230192 -RET R833C Likely Oncogenic Likely Gain-of-function 21810974 -RET V804M Oncogenic Gain-of-function 17047083 -RET E768D Likely Oncogenic Likely Gain-of-function 10445857 -RET C634R Oncogenic Gain-of-function 9230192 -RET R886W Oncogenic Gain-of-function 21551259 -RET V804L Likely Oncogenic Likely Gain-of-function 15184865, 9242375 -RET Fusions Likely Oncogenic Likely Gain-of-function 25064355, 24561444, 22327623 -RET E632_L633del Likely Oncogenic Gain-of-function 9191060 -RET C609Y Oncogenic Gain-of-function 9230192 -RET S765P Likely Neutral Loss-of-function 11438491 -RET C634W Likely Oncogenic Likely Gain-of-function 17664273, 9230192 -RET E511K Likely Oncogenic Likely Gain-of-function 20103606, 21551259 -RET M918V Likely Oncogenic Likely Gain-of-function 21810974 -RET K603Q Likely Oncogenic Likely Gain-of-function 15277225, 11746981 -RET S904F Likely Oncogenic Likely Gain-of-function 21810974 -RET C630R Oncogenic Gain-of-function 9230192 -RET S891A Oncogenic Gain-of-function 24561444, 20554711 -RET L790F Oncogenic Gain-of-function 20444924, 15753368 -RET RET-CCDC6 Fusion Oncogenic Gain-of-function 23578175 -RET R897Q Likely Neutral Loss-of-function 11438491 -RET M918T Oncogenic Gain-of-function 8755580, 22584710, 7824936, 9681850, 24561444 -RET C634Y Likely Oncogenic Gain-of-function 9230192 -RET A919V Likely Oncogenic Likely Gain-of-function 19186126 -RET E921K Likely Neutral Loss-of-function 11438491 -RET V804G Likely Neutral Likely Loss-of-function 15184865 -RET G885R Likely Neutral Likely Neutral 25733075, 24336963 -RET M848T Likely Oncogenic Likely Gain-of-function 21810974 -RET T338I Likely Neutral Likely Neutral 21810974 -RET C634S Likely Oncogenic Gain-of-function 15277225 -RET KIF5B-RET Fusion Oncogenic Gain-of-function 22327624 -RET D631G Likely Neutral Likely Neutral 10049754 -RET I852M Likely Oncogenic Likely Gain-of-function 21711375, 11295841 -RET A919P Inconclusive Inconclusive 16928683 -RET D631A Likely Neutral Likely Neutral 10049754 -RET F893L Likely Neutral Loss-of-function 11438491 -RET Y806C Likely Oncogenic Likely Gain-of-function 19029224 -RET Y791F Likely Oncogenic Gain-of-function 15753368, 9506724, 12490841, 17209045 -RET C620R Oncogenic Gain-of-function 9230192 -RET A883F Oncogenic Gain-of-function 24561444 -RET M980T Likely Neutral Likely Neutral 11438491 -RET C611Y Oncogenic Gain-of-function 9230192 -RET V648I Likely Neutral Likely Neutral 21810974 -RET A883T Oncogenic Gain-of-function 15531548, 21810974 -RET R873Q Likely Neutral Loss-of-function 11438491 -RUNX1 Truncating Mutations Likely Oncogenic Likely Loss-of-function 15864279, 15386419, 17394134 -RUNX1 R174Q Oncogenic Loss-of-function 25490895, 21725049, 17290219 -RUNX1 R201Q Likely Oncogenic Loss-of-function 10508512 -RUNX1 RUNX1-RUNX1T1 Fusion Likely Oncogenic Loss-of-function 19414342, 21174539, 4125056, 9819404 -RUNX1 Amplification Oncogenic Gain-of-function 25592647 -RUNX1 D171G Likely Oncogenic Likely Loss-of-function 22318203 -RUNX1 H78Q Likely Oncogenic Loss-of-function 22318203 -RUNX1 D171N Oncogenic Loss-of-function 18192504, 12393679 -RUNX1 R139G Likely Oncogenic Loss-of-function 22318203 -RUNX1 R166Q Likely Oncogenic Loss-of-function 10508512 -RUNX1 R177* Oncogenic Loss-of-function 10068652, 11830488, 15156185 -RUNX1 G42R Inconclusive Inconclusive 18192504, 12874780, 12393679 -RUNX1 Y113* Oncogenic Loss-of-function 18192504 -RUNX1 S291fsX300 Oncogenic Loss-of-function 18192504 -RUNX1 K83N Likely Oncogenic Loss-of-function 11830488, 15156185 -RUNX1 K83E Likely Oncogenic Loss-of-function 11830488, 15156185 -RUNX1 R174* Oncogenic Gain-of-function 26021490, 20549580 -RUNX1 R177Q Oncogenic Loss-of-function 11830488, 18192504 -RUNX1 RUNX1-EVI1 Fusion Likely Oncogenic Loss-of-function 15156182, 19016745 -RUNX1 P173S Oncogenic Loss-of-function 18192504 -RUNX1 W279* Likely Oncogenic Likely Loss-of-function 25893166 -RUNX1 S70fsX93 Oncogenic Loss-of-function 18192504 -RUNX1 R80C Likely Oncogenic Loss-of-function 15156185 -RUNX1 Fusions Likely Oncogenic Likely Loss-of-function 21174539 -RUNX1 A122* Likely Oncogenic Likely Loss-of-function 18192504 -RUNX1 TEL-RUNX1 Fusion Likely Oncogenic Loss-of-function 15156184 +FAM58A Truncating Mutations Likely Oncogenic Likely Loss-of-function 24218572, 18297069 +CBL H94Y Inconclusive Inconclusive 20126411, 26676746 +CBL M374V Likely Neutral Likely Neutral 26676746 +CBL R420Q Oncogenic Loss-of-function 25178484, 17446348, 19387008, 19734451 +CBL V391I Likely Oncogenic Loss-of-function 26676746 +CBL Deletion Likely Oncogenic Likely Loss-of-function 19276253, 19901108, 22315494 +CBL W802* Likely Oncogenic Likely Gain-of-function 20126411 +CBL Y371H Oncogenic Loss-of-function 23696637, 26676746 +CBL V430M Likely Neutral Likely Neutral 26676746 +CBL H398Y Likely Oncogenic Loss-of-function 19387008 +CBL Y371S Oncogenic Loss-of-function 19620960 +CBL K382E Likely Oncogenic Loss-of-function 25178484, 26676746 +CBL Truncating Mutations Likely Oncogenic Likely Loss-of-function 20508043, 20694012, 22315494 +CBL S376F Likely Oncogenic Loss-of-function 19387008 +CBL P417A Likely Oncogenic Loss-of-function 19387008 +CBL P428L Likely Neutral Likely Neutral 26676746 +CBL C381A Likely Oncogenic Loss-of-function 25178484, 26676746 +CBL C396R Likely Oncogenic Loss-of-function 26676746 +CBL S80N Inconclusive Inconclusive 20126411, 26676746 +CBL G375P Likely Oncogenic Loss-of-function 26676746 +CBL P395A Likely Oncogenic Loss-of-function 26676746 +CBL H398Q Likely Oncogenic Loss-of-function 26676746 +CBL D390Y Likely Oncogenic Loss-of-function 25178484 +CBL L399V Likely Oncogenic Loss-of-function 26676746 +CBL C384R Oncogenic Loss-of-function 23696637 +CBL Q367P Oncogenic Loss-of-function 19620960 +CBL N454D Likely Neutral Neutral 19387008 +CBL Q249E Likely Oncogenic Likely Gain-of-function 20126411 +SHOC2 M173I Likely Oncogenic Loss-of-function 25137548 +SHOC2 S2G Likely Oncogenic Loss-of-function 19684605, 23918763 +TERT H412Y Likely Oncogenic Loss-of-function 18042801 +TERT Promoter Mutations Oncogenic Gain-of-function 23348506, 23348503, 23887589, 24657534, 25048572, 23530248 +TERT P704S Likely Oncogenic Loss-of-function 18042801 +TERT Y846C Likely Oncogenic Loss-of-function 18042801 +TERT C250T Oncogenic Gain-of-function 23348506, 23348503, 23887589, 26389665, 24657534, 23530248 +TERT Amplification Likely Oncogenic Likely Gain-of-function 25219713, 18482052, 25301727 +TERT H876Q Likely Oncogenic Loss-of-function 18042801 +TERT C228T Oncogenic Gain-of-function 23348506, 23348503, 23887589, 24657534, 23530248 +DICER1 E1705K Likely Oncogenic Loss-of-function 22187960 +DICER1 E1705A Likely Oncogenic Loss-of-function 17920623 +DICER1 D1709N Oncogenic Loss-of-function 26033159, 22187960 +DICER1 D1709A Likely Oncogenic Likely Loss-of-function 22187960 +DICER1 Truncating Mutations Likely Oncogenic Likely Loss-of-function 20305640, 22133720, 21501861, 22353998, 21266384 +DICER1 D1709E Likely Oncogenic Likely Loss-of-function 22187960 +DICER1 D1810A Likely Oncogenic Loss-of-function 17920623 +DICER1 G1809K Likely Oncogenic Loss-of-function 26033159 +DICER1 G1809R Oncogenic Loss-of-function 26033159 +DICER1 Deletion Likely Oncogenic Likely Loss-of-function 20305640, 26513514, 27295554, 19903759, 22353998 +PTPRT T844M Likely Oncogenic Loss-of-function 24493670 +PTPRT A1022E Oncogenic Loss-of-function 24395800 +PTPRT R1343L Likely Oncogenic Loss-of-function 15155950 +PTPRT A707T Likely Oncogenic Likely Loss-of-function 20230342 +PTPRT Q984K Likely Oncogenic Loss-of-function 15155950, 22389709 +PTPRT N1125I Likely Oncogenic Loss-of-function 15155950, 22389709 +PTPRT Y412F Likely Oncogenic Likely Loss-of-function 20230342 +PTPRT Y280H Likely Oncogenic Likely Loss-of-function 18644975 +PTPRT L708P Likely Oncogenic Likely Loss-of-function 20230342 +PTPRT R1040L Oncogenic Likely Loss-of-function 24395800 +PTPRT A209T Likely Oncogenic Likely Loss-of-function 18644975 +PTPRT F74S Likely Oncogenic Likely Loss-of-function 15155950, 18644975 +PTPRT V648G Likely Oncogenic Likely Loss-of-function 20230342 +PTPRT R453C Likely Oncogenic Likely Loss-of-function 20230342 +PTPRT Promoter Hypermethylation Oncogenic Loss-of-function 25009298, 25982282, 23096495 +PTPRT Q479E Likely Oncogenic Likely Loss-of-function 20230342 +PTPRT S492F Likely Oncogenic Likely Loss-of-function 20230342 +PTPRT T1365M Likely Oncogenic Loss-of-function 15155950 +PTPRT F248S Likely Oncogenic Likely Loss-of-function 18644975 +PTPRT N510K Likely Oncogenic Likely Loss-of-function 20230342 +PTPRT V995M Likely Oncogenic Loss-of-function 24317090, 17360477 +PTPRT Truncating Mutations Likely Oncogenic Likely Loss-of-function 15155950, 20133777, 21517784 +PTPRT K218T Likely Oncogenic Likely Loss-of-function 18644975 +PTPRT T605M Likely Oncogenic Likely Loss-of-function 20230342 +PTPRT R1209W Likely Oncogenic Loss-of-function 15155950 +PTPRT D927G Likely Oncogenic Loss-of-function 22389709 +RHEB Y35H Likely Oncogenic Gain-of-function 24631838, 22819219 +RHEB Y35C Oncogenic Gain-of-function 24631838, 22819219 +RHEB Y35N Oncogenic Gain-of-function 24631838, 27399332, 22819219, 26255626 +SHQ1 Deletion Likely Oncogenic Likely Loss-of-function 19383767, 19019820, 20579941 +SHQ1 Truncating Mutations Likely Oncogenic Likely Loss-of-function +CCND2 Amplification Likely Oncogenic Likely Gain-of-function 8114739 +RAD50 L234fs Likely Oncogenic Likely Loss-of-function 16474176, 14684699, 16385572 +RAD50 Deletion Likely Oncogenic Likely Loss-of-function 12208847, 2659437, 14684699, 15309560 +RAD50 L1273F Likely Oncogenic Loss-of-function 24934408 +RAD50 Truncating Mutations Likely Oncogenic Likely Loss-of-function 12208847, 16288216, 21892167, 14684699 +CCND3 Amplification Likely Oncogenic Likely Gain-of-function 8114739 +CCND3 D286_L292trunc Likely Oncogenic Likely Gain-of-function 9832503 +CCND3 I290R Likely Oncogenic Likely Gain-of-function 2876518, 24913233, 22885699 +CCND3 T283A Likely Oncogenic Gain-of-function 2876518, 24913233, 22885699 +CCND3 T286A Likely Oncogenic Gain-of-function 9832503 +CCND3 I290A Likely Oncogenic Likely Gain-of-function 9832503 +CCND3 P284L Likely Oncogenic Likely Gain-of-function 2876518, 24913233, 22885699 +CCND3 Q276* Likely Oncogenic Gain-of-function 2876518, 24913233, 22885699 +RIT1 A77P Oncogenic Gain-of-function 24469055 +RIT1 A77T Likely Oncogenic Likely Gain-of-function 26714497 +RIT1 M90I Oncogenic Gain-of-function 24469055 +RIT1 A77S Oncogenic Gain-of-function 24469055 +CCNE1 Amplification Oncogenic Gain-of-function 8618861, 15838514, 12845634, 24605326 +CCNE1 Overexpression Oncogenic Gain-of-function 8618861, 15838514, 12845634, 24605326 +RYBP Truncating Mutations Likely Oncogenic Likely Loss-of-function 19098711 +TGFBR1 C41Y Likely Oncogenic Loss-of-function 21358634 +TGFBR1 N45S Likely Oncogenic Loss-of-function 21358634, 23358096 +TGFBR1 R487Q Likely Oncogenic Likely Loss-of-function 16928994, 25116393, 16791849 +TGFBR1 S241L Likely Oncogenic Likely Loss-of-function 16791849 +TGFBR1 G52R Likely Oncogenic Loss-of-function 21358634, 23358096 +TGFBR1 Truncating Mutations Likely Oncogenic Likely Loss-of-function 10656986, 11212236 +TGFBR1 S387Y Likely Oncogenic Loss-of-function 9809982 +TGFBR1 P83L Likely Oncogenic Loss-of-function 21358634 +TGFBR1 TGFBR1*6A Likely Oncogenic Loss-of-function 17848956, 10582683, 20429896, 16204663, 19882361, 22905183 +TGFBR2 R537P Likely Oncogenic Likely Gain-of-function 18339844 +TGFBR2 P525L Likely Oncogenic Loss-of-function 7862150 +TGFBR2 D404G Likely Oncogenic Loss-of-function 8668164 +TGFBR2 Deletion Likely Oncogenic Likely Loss-of-function 27558455, 25521327, 25736321 +TGFBR2 E526Q Likely Oncogenic Loss-of-function 18339844, 10789724 +TGFBR2 Truncating Mutations Likely Oncogenic Likely Loss-of-function 16310402, 17456004, 17985359, 9927040, 11309634, 7585632 +MSH6 T1219I Likely Oncogenic Likely Loss-of-function 11709755, 24362816, 22102614, 23621914 +MSH6 S144I Likely Neutral Likely Neutral 21120944 +MSH6 R1076C Likely Oncogenic Likely Loss-of-function 21056691, 19072991 +MSH6 Deletion Likely Oncogenic Likely Loss-of-function 25255306, 24090359, 21970482, 12019211, 22781090 +MSH6 F1088Sfs*2 Oncogenic Loss-of-function 9808525, 11474654, 19254532, 9331106 +MSH6 R1095H Likely Neutral Likely Neutral 22581703, 24040339, 12522549, 23621914 +MSH6 F1088Lfs*5 Oncogenic Loss-of-function 12732731, 11474654, 10959092, 9510473, 19254532, 21637783 +MSH6 Truncating Mutations Likely Oncogenic Likely Loss-of-function 9822680, 9111312, 1651234, 9564049 +MSH6 R976H Likely Oncogenic Likely Loss-of-function 11709755, 24362816, 11807791, 18790734 +MSH6 V509A Likely Neutral Likely Neutral 24362816 +MSH6 R922* Oncogenic Loss-of-function 24362816, 19254532 +MSH6 E946* Oncogenic Loss-of-function 12732731, 22810696, 19254532 +MSH6 E1322* Oncogenic Loss-of-function 24755471, 22810696, 19254532 +MSH6 G39E Likely Neutral Likely Neutral 24362816 +KMT2D Deletion Likely Oncogenic Likely Loss-of-function 24633898, 24240169, 26366712 +KMT2D Truncating Mutations Likely Oncogenic Likely Loss-of-function 24633898, 24240169, 26366712 +LATS1 Truncating Mutations Likely Oncogenic Loss-of-function 9988269, 23230145, 11850843 +LATS1 Deletion Likely Oncogenic Likely Loss-of-function 9988269, 23573293, 26040669 +PBRM1 Deletion Likely Oncogenic Likely Loss-of-function 18339845, 21248752, 23867514, 22949125 +PBRM1 N1333Gfs* Oncogenic Loss-of-function 25911086 +PBRM1 Truncating Mutations Likely Oncogenic Likely Loss-of-function 18339845, 24613357, 21248752, 22949125, 21654818 +SF3B1 H662D Likely Oncogenic Switch-of-function 25428262 +SF3B1 R625D Likely Oncogenic Switch-of-function 24434863 +SF3B1 G742D Likely Oncogenic Switch-of-function 24434863, 25428262, 21909114 +SF3B1 R625G Likely Oncogenic Switch-of-function 25788694, 26565915 +SF3B1 K666M Likely Oncogenic Switch-of-function 24434863 +SF3B1 R625C Likely Oncogenic Switch-of-function 24434863, 26565915, 23861464 +SF3B1 K666R Oncogenic Switch-of-function 25428262, 21909114 +SF3B1 R957Q Likely Oncogenic Switch-of-function 23160465 +SF3B1 K700R Likely Oncogenic Likely Switch-of-function 24434863, 26565915, 26619011, 25428262 +SF3B1 R625H Likely Oncogenic Switch-of-function 24434863, 26565915, 23861464 +SF3B1 H662Q Likely Oncogenic Switch-of-function 25428262, 21909114 +SF3B1 R625L Likely Oncogenic Switch-of-function 24434863, 26565915, 23861464 +SF3B1 K700E Likely Oncogenic Switch-of-function 25424858, 24434863, 26565915, 24854990, 23335386, 25428262, 23160465, 27622333, 21909114 +SF3B1 E622Q Likely Oncogenic Switch-of-function 26565915, 25428262, 21909114 +SF3B1 K666N Likely Oncogenic Switch-of-function 24434863, 25788694 +SF3B1 H662R Likely Oncogenic Switch-of-function 25428262, 21909114 +SF3B1 E622D Likely Oncogenic Switch-of-function 25428262, 21909114 +SF3B1 K666T Likely Oncogenic Switch-of-function 24434863, 26842708 +LATS2 Deletion Oncogenic Loss-of-function 21245096 +EGFR V769_D770insGVV Oncogenic Gain-of-function 23371856, 19536777, 24353160, 21764376, 18676761, 15897572, 17686547, 17192902 +EGFR L703P Likely Oncogenic Likely Gain-of-function 19020901 +EGFR S720P Likely Oncogenic Likely Gain-of-function 22760226, 15897572 +EGFR S784F Likely Oncogenic Gain-of-function 20522446, 21531810, 19147750, 21841502 +EGFR Exon 19 insertion Oncogenic Gain-of-function 21422421, 22190593 +EGFR L858Q Likely Oncogenic Likely Gain-of-function 24743239 +EGFR Exon 19 deletion Oncogenic Gain-of-function 15329413, 18000506, 15118125, 19536777, 18458038, 15118073, 22019513, 23566546, 23559152, 24457318, 22760226, 23749122, 17192902 +EGFR D770_N771insVDSVDNP Oncogenic Gain-of-function 23371856, 19536777, 24353160, 21764376, 18676761, 15897572, 21841502, 17686547 +EGFR K745_A750del Oncogenic Gain-of-function 15118073, 15329413, 25179728, 15118125 +EGFR T710A Likely Oncogenic Likely Gain-of-function 23912954 +EGFR H773dup Oncogenic Gain-of-function 24353160 +EGFR G863S Likely Oncogenic Likely Gain-of-function 18000506 +EGFR Y727H Likely Oncogenic Likely Gain-of-function 18000506 +EGFR E884K Oncogenic Gain-of-function 16407879, 19015641 +EGFR T790M Oncogenic Gain-of-function 15728811, 18227510, 15737014 +EGFR G796S Likely Oncogenic Gain-of-function 18193092 +EGFR L747V Likely Oncogenic Likely Gain-of-function 23242437, 22190593 +EGFR H773L Oncogenic Gain-of-function 17974985 +EGFR R841K Likely Neutral Likely Loss-of-function 18193092 +EGFR E746V Likely Oncogenic Likely Gain-of-function 16467085, 18000506 +EGFR S768_D770dup Oncogenic Gain-of-function 23371856, 19536777, 24353160, 21764376, 18676761, 23749122, 15897572, 17686547 +EGFR H870R Likely Neutral Likely Neutral 19671738, 21841502 +EGFR P691S Likely Oncogenic Likely Gain-of-function 22483783, 18000506 +EGFR L858M Likely Oncogenic Likely Gain-of-function 25232377 +EGFR R108K Oncogenic Gain-of-function 24120142, 17177598 +EGFR E746Q Likely Oncogenic Likely Gain-of-function 16467085 +EGFR L747_E749del Oncogenic Gain-of-function 16467085, 15118073, 15329413, 25179728, 15118125 +EGFR E709Q Likely Oncogenic Likely Gain-of-function 19671738, 15897572 +EGFR I744_K745delinsKIPVAI Oncogenic Gain-of-function 15118073, 15329413, 21841502, 15118125 +EGFR V726M Likely Oncogenic Likely Gain-of-function 18000506 +EGFR W731L Likely Oncogenic Gain-of-function 20942962 +EGFR A750_E758delinsP Oncogenic Gain-of-function 15118073, 15329413, 18261621, 15118125 +EGFR S464L Likely Oncogenic Likely Gain-of-function 25633215 +EGFR V774M Likely Oncogenic Likely Gain-of-function 21531810 +EGFR S921R Likely Neutral Inconclusive 19020901 +EGFR A763_Y764insFQEA Oncogenic Gain-of-function 24353160 +EGFR P753S Likely Oncogenic Likely Gain-of-function 16467085, 16106023, 25130612, 24934779 +EGFR N826Y Likely Oncogenic Likely Gain-of-function 21531810, 19147750 +EGFR S752_I759del Likely Oncogenic Likely Gain-of-function 23371856, 19536777, 24353160, 21764376, 18676761, 15897572, 17686547, 17192902 +EGFR E746_S752delinsI Oncogenic Gain-of-function 15118073, 15329413, 15118125, 17192902 +EGFR E709V Likely Oncogenic Likely Gain-of-function 21531810, 19536777, 26051236 +EGFR G465E Likely Oncogenic Likely Gain-of-function 26416732 +EGFR L861F Likely Oncogenic Likely Gain-of-function 21531810, 19536777, 19147750, 17177598, 26051236, 21252719 +EGFR S768I Oncogenic Gain-of-function 19536777, 16205628, 25521406, 25521405, 23242437, 19147750, 18676761, 23912954, 25179728, 25130612 +EGFR E709G Likely Oncogenic Likely Gain-of-function 21531810, 26051236, 23912954 +EGFR L747_T751del Oncogenic Gain-of-function 18325048, 23242437, 15118073, 15329413, 23387505, 15897572, 15118125 +EGFR E866K Likely Neutral Loss-of-function 19147750 +EGFR L747_S752del Oncogenic Gain-of-function 16467085, 15118073, 15329413, 15118125, 17192902 +EGFR G719S Oncogenic Gain-of-function 21531810, 16187797, 26206867 +EGFR A767_V769dup Oncogenic Gain-of-function 23371856, 19536777, 24353160, 21764376, 18676761, 23912954, 23749122, 15897572, 17686547 +EGFR L861P Likely Oncogenic Likely Gain-of-function 21531810, 17177598, 18000506 +EGFR L858R Oncogenic Gain-of-function 15118073, 15329413, 15118125 +EGFR L838P Likely Oncogenic Likely Gain-of-function 21531810 +EGFR L747P Oncogenic Gain-of-function 21531810, 18508816, 19536777, 26339441, 26001153, 22190593 +EGFR Fusions Likely Oncogenic Likely Gain-of-function 27102076, 23917401 +EGFR D761N Likely Oncogenic Gain-of-function 19147750, 26870223 +EGFR K467T Likely Oncogenic Likely Gain-of-function 25633215 +EGFR G465R Likely Oncogenic Likely Gain-of-function 26416732 +EGFR T785A Likely Oncogenic Gain-of-function 20942962 +EGFR E746_S752delinsV Oncogenic Gain-of-function 15118073, 15329413, 22483783, 25179728, 15710947, 15118125 +EGFR E330K Oncogenic Gain-of-function 24212795 +EGFR E734Q Likely Oncogenic Gain-of-function 20942962 +EGFR T725M Likely Oncogenic Gain-of-function 24743239 +EGFR D761Y Likely Oncogenic Likely Gain-of-function 17973572, 17545553, 19632948, 17085664, 17192902 +EGFR EGFRvV Oncogenic Gain-of-function 17189397, 1730638, 2790960 +EGFR EGFRvIII Oncogenic Gain-of-function 8895767, 17189397, 19324552, 8052651, 23777544, 12438278 +EGFR L861Q Oncogenic Gain-of-function 21531810, 18508816, 16467085, 17177598, 25668120, 21841502, 15897572, 21252719, 19536777, 18325048, 19147750, 26051236, 18676761, 23912954, 24457318, 22760226, 20808254, 23749122, 24285021 +EGFR P772_V774dup Oncogenic Gain-of-function 23371856, 19536777, 24353160, 21764376, 18676761, 25179728, 15897572, 17686547 +EGFR G719C Likely Oncogenic Likely Gain-of-function 21531810, 15118073, 19147750, 18261621, 26206867, 21841502 +EGFR A767_V769del Likely Oncogenic Likely Gain-of-function 23371856, 19536777, 24353160, 21764376, 18676761, 15897572, 17686547 +EGFR E746G Likely Oncogenic Likely Gain-of-function 21531810 +EGFR T34_A289del Oncogenic Gain-of-function 27216155 +EGFR G735S Oncogenic Gain-of-function 18193092, 25435280 +EGFR S768_V769insVAS Oncogenic Gain-of-function 23371856, 19536777, 24353160, 21764376, 18676761, 15897572, 21841502, 17686547 +EGFR H773insLGNP Oncogenic Gain-of-function 23371856, 19536777, 24353160, 21764376, 18676761, 23749122, 15897572, 17686547 +EGFR EGFRvII Oncogenic Gain-of-function 24893890, 17189397 +EGFR G810S Likely Oncogenic Gain-of-function 19147750 +EGFR L861R Oncogenic Gain-of-function 21531810, 17177598, 24743239, 21841502, 21252719 +EGFR R776H Likely Oncogenic Gain-of-function 23242437, 20512075, 23358982 +EGFR E746_S752delinsA Oncogenic Gain-of-function 15118073, 15329413, 15710947, 15118125 +EGFR E746_A750del Oncogenic Gain-of-function 18508816, 18325048, 16467085, 15118073, 15329413, 18261621, 22483783, 25179728, 16373402, 15710947, 15897572, 15118125 +EGFR T263P Oncogenic Gain-of-function 17177598 +EGFR G724S Oncogenic Gain-of-function 16166444, 24894453, 24743239 +EGFR S645C Likely Oncogenic Likely Gain-of-function 27478040 +EGFR H773Y Likely Oncogenic Likely Gain-of-function 19536777, 17974985, 18676761 +EGFR V843I Likely Oncogenic Gain-of-function 23380224, 21172876, 19536777, 25057940, 18000506, 18355544 +EGFR V774A Likely Oncogenic Likely Gain-of-function 21531810 +EGFR G863D Likely Oncogenic Gain-of-function 17376509, 16204011, 15897572 +EGFR S492R Likely Oncogenic Likely Switch-of-function 22270724 +EGFR Exon 19 deletion/insertion Oncogenic Gain-of-function 15329413, 18000506, 15118125, 19536777, 18458038, 15118073, 22019513, 23566546, 23559152, 24457318, 22760226, 23749122, 17192902 +EGFR C620Y Oncogenic Gain-of-function 24747966 +EGFR G857E Likely Oncogenic Likely Gain-of-function 23139256, 18000506, 19238633, 25435280 +EGFR P772_H773insYNP Oncogenic Gain-of-function 23371856, 19536777, 24353160, 21764376, 18676761, 15897572, 17686547 +EGFR A289V Oncogenic Gain-of-function 24120142, 17177598, 22588883 +EGFR D770_N771insSVD Oncogenic Gain-of-function 23371856, 19536777, 24353160, 21764376, 18676761, 15897572, 17686547 +EGFR E746_T751insIP Oncogenic Gain-of-function 18325048, 22190593 +EGFR EGFR-RAD51 Fusion Oncogenic Gain-of-function 27102076 +EGFR V742A Likely Oncogenic Gain-of-function 21531810, 23605641, 19147750, 16152581 +EGFR A864T Oncogenic Gain-of-function 23585556, 19147750, 21761100, 22722798, 16551849 +EGFR I941R Likely Neutral Likely Loss-of-function 24063894 +EGFR EGFR-KDD Oncogenic Gain-of-function 26286086 +EGFR E758G Likely Oncogenic Likely Gain-of-function 19536777 +EGFR V769M Likely Oncogenic Likely Gain-of-function 21531810, 23749122 +EGFR L704N Likely Neutral Loss-of-function 24063894 +EGFR L747S Likely Oncogenic Likely Gain-of-function 17973572, 18309959, 18645621, 19632948, 18981003 +EGFR R776C Likely Oncogenic Gain-of-function 19147750 +EGFR E746_T751delinsL Oncogenic Gain-of-function 15118073, 15329413, 18261621, 15118125 +EGFR K745M Likely Neutral Loss-of-function 21081186 +EGFR I853T Likely Neutral Loss-of-function 19147750 +EGFR P848L Likely Neutral Likely Neutral 23897956, 22848293, 25176975, 23912954, 17877814 +EGFR L747_P753del Oncogenic Gain-of-function 15118073, 15329413, 25179728, 15118125 +EGFR D770_N771insNPG Oncogenic Gain-of-function 23371856, 19536777, 24353160, 21764376, 18676761, 15897572, 17686547 +EGFR I491M Likely Oncogenic Likely Neutral 25633215 +EGFR N826S Oncogenic Gain-of-function 19147750, 15897572 +EGFR E709_T710delinsD Oncogenic Gain-of-function 21531810, 26206867 +EGFR V769_D770insASV Oncogenic Gain-of-function 23371856, 19536777, 24353160, 21764376, 18676761, 15897572, 17686547 +EGFR EGFR-PURB Fusion Likely Oncogenic Likely Gain-of-function 27102076 +EGFR L692F Likely Oncogenic Likely Gain-of-function 23912954 +EGFR E746_A750delinsQ Oncogenic Gain-of-function 15118073, 15329413, 15118125, 17192902 +EGFR G719A Oncogenic Gain-of-function 21531810, 26206867 +EGFR L747_A750del Oncogenic Gain-of-function 16467085, 15118073, 15329413, 15118125 +EGFR L838V Likely Oncogenic Gain-of-function 19147750 +EGFR E709A Likely Oncogenic Gain-of-function 21531810, 19671738, 23242437, 18261621, 23566546, 22483783, 23749122, 20479403, 15710947, 18372921, 21841502 +EGFR Exon 20 insertion Oncogenic Gain-of-function 23371856, 19536777, 24353160, 21764376, 18676761, 15897572, 17686547 +EGFR E868G Likely Oncogenic Gain-of-function 20942962, 16870303 +EGFR E746_T751delinsVA Oncogenic Gain-of-function 18508816, 15118073, 15329413, 15897572, 15118125 +EGFR E804G Likely Oncogenic Gain-of-function 18193092 +EGFR K806A Likely Oncogenic Likely Gain-of-function 19536777 +EGFR H773_V774insH Oncogenic Gain-of-function 24353160 +EGFR Y801H Likely Oncogenic Gain-of-function 20942962, 17224267 +EGFR D837N Likely Oncogenic Likely Gain-of-function 23749122 +EGFR D587H Likely Oncogenic Gain-of-function 26571394, 27245685 +EGFR N771_H773dup Oncogenic Gain-of-function 23371856, 19536777, 24353160, 21764376, 18676761, 23912954, 15897572, 17686547 +EGFR E746_T751delinsA Oncogenic Gain-of-function 15118073, 15329413, 15710947, 15897572, 15118125 +EGFR R836C Likely Oncogenic Likely Gain-of-function 23912954 +EGFR G598V Oncogenic Gain-of-function 24120142, 17177598, 22588883 +EGFR R324L Oncogenic Gain-of-function 24212795 +EGFR A750_E758del Oncogenic Gain-of-function 18325048, 15118073, 15329413, 15118125 +EGFR D770_N771insD Oncogenic Gain-of-function 23371856, 19536777, 24353160, 21764376, 18676761, 15897572, 17686547 +EGFR L747F Likely Oncogenic Likely Gain-of-function 16533793, 26773740, 24385129, 23485129, 26096169, 22190593 +EGFR L747_P753delinsS Oncogenic Gain-of-function 18508816, 15118073, 15329413, 19147750, 25179728, 15710947, 15897572, 15118125 +EGFR Amplification Oncogenic Gain-of-function 24120142, 10728703 +EGFR A859_L883delinsV Likely Oncogenic Likely Gain-of-function 18325048 +EGFR A750P Oncogenic Gain-of-function 19625781, 25179728, 15737014, 16187797 +EGFR E709K Oncogenic Gain-of-function 19726454, 23566546, 18000506, 25179728, 25130612, 23749122, 15710947, 26206867 +EGFR C797Y Likely Oncogenic Gain-of-function 20942962 +EGFR V765A Likely Oncogenic Likely Gain-of-function 15897572 +EGFR P596L Likely Oncogenic Likely Gain-of-function 17177598, 23243055 +EGFR G719D Likely Oncogenic Likely Gain-of-function 21531810, 18000506, 26206867 +EGFR L747_T751delinsP Oncogenic Gain-of-function 15118073, 15329413, 15710947, 15118125 +EGFR T783A Likely Oncogenic Likely Gain-of-function 18676761, 15897572 +EGFR L833V Oncogenic Gain-of-function 16205628, 21949883, 23912954, 25130612, 20808254, 21422421 +EGFR EGFRvIV Oncogenic Gain-of-function 20676128, 23007009 +EGFR D770_P772dup Oncogenic Gain-of-function 23371856, 19536777, 24353160, 21764376, 18676761, 23749122, 15897572, 17686547 +EGFR C628Y Likely Neutral Neutral 24747966 +EGFR L747_A750delinsP Oncogenic Gain-of-function 18508816, 15118073, 15329413, 15118125, 17192902 +EGFR V851A Likely Neutral Loss-of-function 19147750 +NKX2-1 Amplification Oncogenic Gain-of-function 17925434, 18212743, 22439932 +NKX2-1 Fusions Likely Oncogenic Likely Gain-of-function 21481790 +NKX2-1 A339V Likely Oncogenic Gain-of-function 19176457 +NKX2-1 TRB-NKX2-1 Fusion Likely Oncogenic Likely Gain-of-function 21481790 +NKX2-1 IGH-NKX2 Fusion Likely Oncogenic Likely Gain-of-function 21481790 +NKX2-1 TRA-NKX2-1 Fusion Likely Oncogenic Likely Gain-of-function 21481790 +EIF1AX A113_splice Oncogenic Gain-of-function 26878173 Krishnamoorthy et al. Abstract# 892, AACR 2016 http://cancerres.aacrjournals.org/content/76/14_Supplement/892 +ARID2 Truncating Mutations Likely Oncogenic Likely Loss-of-function 23047306, 21822264, 15985610, 16847454 +ARID2 Deletion Likely Oncogenic Likely Loss-of-function 23047306, 22095441, 15985610, 16847454 +BRD4 BRD4-NUT Fusion Oncogenic Gain-of-function 23604113, 21447744, 25512383, 20676058, 17934517, 20871596 +BRD4 Fusions Oncogenic Likely Gain-of-function 12543779, 23128391, 25564152 +BRD4 Amplification Likely Oncogenic Gain-of-function 12192049, 19596781, 15456879 +HIST1H1C S102F Likely Oncogenic Likely Loss-of-function 24362818 +ERRFI1 Deletion Likely Oncogenic Likely Loss-of-function 16648858, 21113414 +ERRFI1 Truncating Mutations Likely Oncogenic Likely Loss-of-function +CHEK2 R117G Likely Oncogenic Loss-of-function 16835864, 16982735 +CHEK2 I157T Inconclusive Inconclusive 16816021, 11571648, 15239132, 11053450, 14612911, 15492928, 11298456, 12049740 +CHEK2 H371Y Likely Oncogenic Loss-of-function 21618645, 25884806 +CHEK2 E321K Likely Oncogenic Loss-of-function 16835864 +CHEK2 K373E Oncogenic Loss-of-function 27716909 +CHEK2 S428F Likely Oncogenic Likely Loss-of-function 16998506, 15649950 +CHEK2 P85L Likely Neutral Neutral 16998506, 15649950 +CHEK2 E161del Likely Oncogenic Loss-of-function 16982735 +PAK1 Amplification Oncogenic Gain-of-function 21482786, 22105362 +TMPRSS2 TMPRSS2-ERG Fusion Oncogenic Gain-of-function 7731694, 16213704, 17043636 +TMPRSS2 Fusions Likely Oncogenic Likely Gain-of-function 16254181, 18283340 +TMPRSS2 T75M Likely Neutral Neutral 11745466, 25040002 +TMPRSS2 TMPRSS2-ETV5 Fusion Likely Oncogenic Likely Gain-of-function 18172298 +TMPRSS2 TMPRSS2-ETV4 Fusion Likely Oncogenic Likely Gain-of-function 16585160 +TMPRSS2 M160V Likely Neutral Neutral 11745466, 25040002 +TMPRSS2 TMPRSS2-ETV1 Fusion Oncogenic Gain-of-function 18563191, 23512661 +H3F3A K28M Likely Oncogenic Likely Switch-of-function 21685365, 22286061 +H3F3A G35V Likely Oncogenic Likely Switch-of-function 21685365, 23079654, 22286061 +H3F3A G35R Likely Oncogenic Likely Switch-of-function 21685365, 23079654, 22286061 +ELF3 I279P Likely Oncogenic Likely Loss-of-function 17148437 +ELF3 Truncating Mutations Likely Oncogenic Likely Loss-of-function 14976186, 17148437 +ELF3 K320E Likely Neutral Likely Neutral 17148437 +ELF3 A312P Likely Oncogenic Likely Loss-of-function 17148437 +ELF3 S330A Likely Neutral Likely Neutral 17148437 +ELF3 S308A Likely Neutral Likely Neutral 17148437 +ELF3 R331P Likely Oncogenic Likely Loss-of-function 17148437 +ROS1 S1986F Likely Oncogenic Likely Gain-of-function 27401242 +ROS1 ROS1-CD74 Fusion Oncogenic Gain-of-function 22919003, 22215748, 18083107, 22327623 +ROS1 CEP85L-ROS1 Fusion Likely Oncogenic Likely Gain-of-function 25204415, 23637631 +ROS1 E1935G Likely Oncogenic Likely Gain-of-function 24218589 +ROS1 FIG-ROS1 Fusion Oncogenic Gain-of-function 12661006, 2827175 +ROS1 G2101A Likely Oncogenic Likely Gain-of-function 22235099, 25688157, 24675041 +ROS1 KDELR2-ROS1 Fusion Likely Oncogenic Likely Gain-of-function 22980976 +ROS1 G1971E Likely Oncogenic Likely Gain-of-function 24218589 +ROS1 D2033N Likely Oncogenic Likely Gain-of-function 26673800 +ROS1 L1951R Inconclusive Inconclusive 25351743 +ROS1 C2060G Likely Oncogenic Likely Gain-of-function 24218589 +ROS1 SLC34A2-ROS1 Fusion Oncogenic Gain-of-function 22919003, 22215748, 22327623 +ROS1 TPM3-ROS1 Fusion Oncogenic Gain-of-function 22327623 +ROS1 TFG-ROS1 Fusion Likely Oncogenic Likely Gain-of-function 24875859 +ROS1 S1986Y Likely Oncogenic Likely Gain-of-function 27401242 +ROS1 G2032R Likely Oncogenic Likely Gain-of-function 25351743, 24047073, 24047072, 23724914, 27401242, 25688157 +ROS1 Fusions Likely Oncogenic Likely Gain-of-function 22919003, 23719267, 22215748 +ROS1 CD74-ROS1 Fusion Oncogenic Gain-of-function 22919003, 22215748, 18083107, 22327623 +ROS1 YWHAE-ROS1 Fusion Likely Oncogenic Likely Gain-of-function 24875859 +ROS1 LIMA1-ROS1 Fusion Likely Oncogenic Likely Gain-of-function 25264305 +ROS1 MSN-ROS1 Fusion Likely Oncogenic Likely Gain-of-function 25264305 +ROS1 EZR-ROS1 Fusion Oncogenic Gain-of-function 22327623 +ROS1 LRIG3-ROS1 Fusion Oncogenic Gain-of-function 22327623 +ROS1 Amplification Likely Oncogenic Likely Gain-of-function 25978031 +ROS1 V2098I Likely Oncogenic Likely Gain-of-function 24218589 +ROS1 SDC4-ROS1 Fusion Oncogenic Gain-of-function 22327623 +ROS1 L1947R Likely Oncogenic Likely Gain-of-function 24218589 +ROS1 CCDC6-ROS1 Fusion Likely Oncogenic Likely Gain-of-function 22975805, 25870798 +ASXL2 Truncating Mutations Likely Oncogenic Likely Loss-of-function 24973361 Li et al. Abstract# 1509, ASH 2016 http://www.bloodjournal.org/content/128/22/1509 +ASXL2 Deletion Likely Oncogenic Likely Loss-of-function 24973361 Li et al. Abstract# 1509, ASH 2016 http://www.bloodjournal.org/content/128/22/1509 +CDH1 D257N Likely Oncogenic Likely Loss-of-function 24690483 +CDH1 R732Q Likely Oncogenic Likely Loss-of-function 15235021, 17545690 +CDH1 T340A Oncogenic Loss-of-function 12588804 +CDH1 Deletion Likely Oncogenic Likely Loss-of-function 23812922, 2070412, 23341533, 19168852, 9515965, 24037103 +CDH1 Epigenetic Silencing Likely Oncogenic Likely Loss-of-function 11313896, 7543680 +CDH1 A617T Likely Oncogenic Loss-of-function 12588804 +CDH1 A634V Oncogenic Loss-of-function 12588804 +CDH1 D254N Oncogenic Loss-of-function 26123647 +CDH1 Truncating Mutations Likely Oncogenic Likely Loss-of-function 8934538, 2070412, 9515965, 17522512 +CDH1 A298T Likely Oncogenic Likely Loss-of-function 24204729 +EPCAM 3' Deletion Oncogenic Loss-of-function 21145788 +TOP1 Truncating Mutations Likely Oncogenic Likely Loss-of-function +EP300 EP300-MLL Fusion Likely Oncogenic Gain-of-function 18778367, 23307074, 9389684, 20980053 +EP300 Deletion Likely Oncogenic Likely Loss-of-function 10700188, 12402157, 12237408 +EP300 Fusions Likely Oncogenic Likely Gain-of-function 25943178, 26293203, 23307074 +EP300 Truncating Mutations Likely Oncogenic Likely Loss-of-function 10700188, 15156177, 12402157, 12237408 +EP300 D1399Y Likely Oncogenic Loss-of-function 12586840, 25151357 +EP300 P1502L Likely Oncogenic Loss-of-function 25151357 +EP300 C1385 Likely Oncogenic Loss-of-function 18273021 +EP300 EP300-MOZ Fusion Likely Oncogenic Gain-of-function 10824998, 23307074, 11243405 +EP300 Y1414C Likely Oncogenic Loss-of-function 25151357 +EP300 R1627 Likely Oncogenic Loss-of-function 18273021 +EPAS1 P531A Likely Oncogenic Likely Gain-of-function 23054256, 14691554, 12086860 +EPAS1 533_534del Likely Oncogenic Likely Gain-of-function 22931260, 23418310 +EPAS1 Y532C Likely Oncogenic Likely Gain-of-function 23361906, 23653463 +EPAS1 A530V Likely Oncogenic Likely Gain-of-function 22931260, 23418310 +EPAS1 A530T Likely Oncogenic Likely Gain-of-function 22931260, 23418310 +EPAS1 P531S Likely Oncogenic Likely Gain-of-function 22931260, 23418310 +EPAS1 P531L Likely Oncogenic Likely Gain-of-function 22931260, 23418310 +EPAS1 534_536del Likely Oncogenic Likely Gain-of-function 22931260, 23418310 +TP53 H179Q Likely Oncogenic Loss-of-function 22540896 +TP53 I255F Likely Oncogenic Likely Loss-of-function 25408419 +TP53 R158C Likely Oncogenic Likely Loss-of-function 17947339 +TP53 H179R Likely Oncogenic Loss-of-function 17361096, 22427690 +TP53 C238F Likely Oncogenic Loss-of-function 20407015 +TP53 G334R Likely Neutral Neutral 25584008 +TP53 R282W Likely Oncogenic Likely Loss-of-function 21445056 +TP53 H168N Likely Oncogenic Likely Loss-of-function 19462533 +TP53 S215G Oncogenic Loss-of-function 17724467, 8023157, 26619011, 22862161, 11900253 +TP53 G266R Likely Oncogenic Loss-of-function 16827139 +TP53 P219S Likely Oncogenic Loss-of-function 10229196, 25584008 +TP53 F338I Likely Oncogenic Likely Loss-of-function 19454241, 20978130 +TP53 R110L Likely Oncogenic Likely Loss-of-function 21445056, 16778209 +TP53 Truncating Mutations Likely Oncogenic Likely Loss-of-function 19336573, 27759562, 16007150, 11753428, 11900253, 21467160 +TP53 P153H Likely Oncogenic Likely Loss-of-function 15781620, 8023157, 11900253 +TP53 Y236C Likely Oncogenic Loss-of-function 16827139 +TP53 Q331H Likely Oncogenic Likely Loss-of-function 26619011, 20978130 +TP53 L330H Likely Oncogenic Likely Loss-of-function 19454241, 20978130 +TP53 L348F Likely Oncogenic Likely Loss-of-function 19454241 +TP53 V197E Likely Oncogenic Likely Loss-of-function 25408419 +TP53 R248L Likely Oncogenic Likely Loss-of-function 26748848, 25584008 +TP53 G244S Oncogenic Loss-of-function 26818906 +TP53 S121F Likely Oncogenic Likely Gain-of-function 15781620 +TP53 R283Q Likely Oncogenic Likely Loss-of-function 7651437 +TP53 C135S Likely Oncogenic Likely Loss-of-function 17914575, 8023157, 11900253 +TP53 K120E Oncogenic Loss-of-function 18524770, 24814347, 17189187 +TP53 R273G Likely Oncogenic Likely Loss-of-function 24677579, 26619011 +TP53 K120M Oncogenic Loss-of-function 17189187 +TP53 R248W Likely Oncogenic Loss-of-function 18762571, 10229196, 25584008 +TP53 H233N Likely Oncogenic Likely Loss-of-function 19462533, 26619011 +TP53 I251S Likely Oncogenic Likely Loss-of-function 26748848 +TP53 R290G Likely Oncogenic Likely Loss-of-function 15781620, 8023157, 26619011, 11900253 +TP53 R280K Oncogenic Loss-of-function 24714748 +TP53 R181H Likely Oncogenic Loss-of-function 20471942 +TP53 C277Q Likely Oncogenic Likely Loss-of-function 7651437 +TP53 H179L Oncogenic Loss-of-function 23150443 +TP53 G266E Likely Oncogenic Likely Loss-of-function 17724467 +TP53 G244R Oncogenic Loss-of-function 11160722 +TP53 Y234C Likely Oncogenic Loss-of-function 10229196, 26748848, 16861262 +TP53 T123A Likely Neutral Likely Neutral 16687402, 18996393 +TP53 K292T Likely Oncogenic Likely Loss-of-function 15781620, 8023157, 26619011, 11900253 +TP53 C176R Likely Oncogenic Loss-of-function 8633021 +TP53 S241F Likely Oncogenic Likely Loss-of-function 21383700 +TP53 F341C Likely Oncogenic Likely Loss-of-function 19454241, 20978130 +TP53 L145R Oncogenic Loss-of-function 8023157, 11900253 +TP53 R337L Likely Oncogenic Likely Loss-of-function 19454241, 20978130, 11481490 +TP53 R175C Likely Oncogenic Likely Loss-of-function 9632751, 26619011, 22955915 +TP53 C135R Likely Oncogenic Loss-of-function 17914575 +TP53 K120R Likely Oncogenic Loss-of-function 7651437, 17189187 +TP53 C238S Likely Oncogenic Loss-of-function 19681600 +TP53 I254T Oncogenic Loss-of-function 25584008 +TP53 S241T Likely Oncogenic Loss-of-function 11896595 +TP53 S121Y Inconclusive Inconclusive 15781620 +TP53 R175H Oncogenic Loss-of-function 15781620, 10713666, 21445056, 25584008, 22114072 +TP53 H179Y Likely Oncogenic Loss-of-function 17530187 +TP53 R248Q Likely Oncogenic Likely Loss-of-function 24814347, 21445056, 16778209 +TP53 R181L Likely Oncogenic Likely Loss-of-function 20471942 +TP53 H193N Likely Oncogenic Loss-of-function 19462533 +TP53 R213Q Likely Oncogenic Loss-of-function 10871862 +TP53 A347T Likely Oncogenic Likely Loss-of-function 19454241, 20978130 +TP53 R156C Likely Oncogenic Likely Loss-of-function 15781620, 8023157, 11900253 +TP53 P278A Likely Oncogenic Likely Loss-of-function 24076587 +TP53 N239S Oncogenic Loss-of-function 22553460 +TP53 V272M Likely Oncogenic Likely Loss-of-function 15037740, 11870884 +TP53 S121A Likely Neutral Likely Gain-of-function 15781620 +TP53 G356A Inconclusive Inconclusive 20978130 +TP53 H179N Likely Oncogenic Likely Loss-of-function 19462533 +TP53 P47S Likely Neutral Neutral 25584008 +TP53 R282Q Likely Oncogenic Likely Loss-of-function 18453682 +TP53 Y163C Likely Oncogenic Loss-of-function 8023157, 23246812, 15037740, 25584008, 11900253, 15077194 +TP53 S121C Inconclusive Inconclusive 15781620 +TP53 H214Q Likely Oncogenic Likely Loss-of-function 15781620, 26619011 +TP53 S240R Likely Oncogenic Likely Loss-of-function 10229196 +TP53 Y234H Likely Oncogenic Loss-of-function 22710932 +TP53 Y236S Likely Oncogenic Loss-of-function 11429705 +TP53 R337H Likely Oncogenic Likely Loss-of-function 19454241, 25584008, 11481490 +TP53 G245S Oncogenic Loss-of-function 2358418, 15037740 +TP53 P151H Likely Oncogenic Likely Loss-of-function 8023157, 22908277, 11900253 +TP53 R248K Likely Oncogenic Likely Loss-of-function 7651437 +TP53 K291E Likely Oncogenic Likely Loss-of-function 15781620, 8023157, 26619011, 11900253 +TP53 R273H Oncogenic Loss-of-function 26181206, 15037740, 25584008 +TP53 H214R Likely Oncogenic Likely Loss-of-function 20407015, 26619011 +TP53 Y236D Likely Oncogenic Loss-of-function 8633021 +TP53 Deletion Likely Oncogenic Likely Loss-of-function 26982726, 27759562, 19477430, 11900253, 12584563 +TP53 DNA binding domain deletions Oncogenic Loss-of-function 8023157, 11900253 +TP53 A161T Likely Oncogenic Likely Loss-of-function 21232794, 16827139 +TP53 P151S Oncogenic Loss-of-function 2857548 +TP53 S215C Likely Oncogenic Likely Loss-of-function 15781620, 26619011, 12917626 +TP53 H297N Likely Neutral Likely Neutral 19462533 +TP53 L344P Likely Oncogenic Loss-of-function 19454241, 20978130, 19106109 +TP53 Q331R Likely Oncogenic Likely Loss-of-function 20978130 +TP53 L330R Likely Oncogenic Likely Loss-of-function 19454241, 20978130 +TP53 R249S Likely Oncogenic Likely Loss-of-function 21445056, 18996393, 14741214 +TP53 K120A Likely Oncogenic Likely Loss-of-function 24814347, 16687402 +TP53 P316L Likely Oncogenic Likely Loss-of-function 10618702, 2553699, 20010306 +TP53 F212Y Inconclusive Inconclusive 15781620 +TP53 G199R Likely Oncogenic Likely Loss-of-function 10229196 +TP53 P250L Likely Oncogenic Likely Loss-of-function 21445056 +TP53 Y220C Oncogenic Loss-of-function 23315175, 15037740, 23630318 +TP53 DNA binding domain missense mutations Oncogenic Loss-of-function 8023157, 11900253 +TP53 G244D Likely Oncogenic Likely Loss-of-function 12901798 +TP53 C229R Likely Oncogenic Likely Loss-of-function 25584008 +TP53 C242Y Likely Oncogenic Loss-of-function 20407015 +TP53 V197L Likely Oncogenic Likely Loss-of-function 11668476 +TP53 R181C Likely Oncogenic Loss-of-function 10229196, 20471942 +TP53 G245D Likely Oncogenic Likely Loss-of-function 25119136, 22803791, 22214764 +TP53 R337C Likely Oncogenic Loss-of-function 19454241, 17311302, 16007150, 19106109, 11753428 +TP53 C242S Likely Oncogenic Loss-of-function 20407015 +TP53 C141Y Likely Oncogenic Likely Loss-of-function 15037740 +TP53 DNA binding domain insertions Oncogenic Loss-of-function 8023157, 11900253 +TP53 K292I Likely Oncogenic Likely Gain-of-function 15781620, 8023157, 11900253 +TP53 V173L Likely Oncogenic Loss-of-function 15037740 +TP53 Y220S Likely Oncogenic Loss-of-function 15977174 +TP53 H193R Likely Oncogenic Likely Loss-of-function 9627118 +TP53 R342P Likely Oncogenic Loss-of-function 19454241, 20978130 +TP53 C277W Likely Oncogenic Likely Loss-of-function 24814347 +TP53 F328V Likely Oncogenic Likely Loss-of-function 19454241 +TP53 V173E Likely Oncogenic Loss-of-function 9472631 +TP53 R156H Likely Oncogenic Loss-of-function 10435620 +TP53 R158H Likely Oncogenic Loss-of-function 10229196, 25584008 +TP53 R273L Likely Oncogenic Loss-of-function 8023157, 15037740, 11900253 +TP53 V274F Likely Oncogenic Likely Loss-of-function 12782597 +TP53 V157D Oncogenic Loss-of-function 23981578 +TP53 K291Q Likely Oncogenic Likely Loss-of-function 15781620, 8023157, 11900253 +TP53 S241Y Likely Oncogenic Loss-of-function 25584008 +TP53 E285K Likely Oncogenic Likely Loss-of-function 20407015 +TP53 P151A Likely Oncogenic Loss-of-function 20407015 +TP53 R280T Likely Oncogenic Likely Loss-of-function 22999923 +TP53 P278L Likely Oncogenic Loss-of-function 16861262 +TP53 E258V Likely Oncogenic Likely Loss-of-function 21445056 +TP53 E285V Oncogenic Loss-of-function 18762572, 25584008 +TP53 T329I Inconclusive Inconclusive 20978130 +TP53 L330P Likely Oncogenic Likely Loss-of-function 20978130 +TP53 M237K Likely Oncogenic Likely Loss-of-function 20505364 +TP53 R158L Likely Oncogenic Loss-of-function 15037740, 25584008, 16861262 +TP53 R290H Likely Oncogenic Likely Loss-of-function 10435620 +TP53 R273C Likely Oncogenic Likely Loss-of-function 15037740, 23863845, 11900253, 23612969 +TP53 E221Q Inconclusive Inconclusive 15781620 +TP53 H115N Inconclusive Inconclusive 19462533 +TP53 R249W Oncogenic Loss-of-function 23612969 +TP53 I162M Likely Oncogenic Likely Loss-of-function 15781620, 8023157, 11900253 +TP53 K120N Likely Oncogenic Loss-of-function 7651437 +TP53 V157F Likely Oncogenic Likely Loss-of-function 21561095, 15037740, 16778209 +TP53 R337P Likely Oncogenic Likely Loss-of-function 19454241, 20978130, 11481490 +TP53 Q144R Likely Oncogenic Likely Loss-of-function 15781620, 8023157, 26619011, 11900253 +TP53 H168R Likely Oncogenic Loss-of-function 18996393 +TP53 I195T Likely Oncogenic Likely Loss-of-function 8023157, 11900253, 12700230 +TP53 V143A Likely Oncogenic Likely Loss-of-function 10435620 +TP53 P278R Likely Oncogenic Loss-of-function 21760996 +TP53 C277R Likely Oncogenic Likely Loss-of-function 7651437 +TP53 R110P Likely Oncogenic Likely Loss-of-function 21445056 +TP53 P278S Likely Oncogenic Loss-of-function 22989750 +TP53 Q144P Likely Oncogenic Likely Loss-of-function 10229196 +TP53 E286K Likely Oncogenic Loss-of-function 15037740 +TP53 G245A Likely Oncogenic Likely Loss-of-function 20589832 +TP53 R249M Likely Oncogenic Loss-of-function 17999388, 15037740 +TP53 H193P Likely Oncogenic Loss-of-function 25584008 +TP53 M133T Likely Oncogenic Likely Loss-of-function 21311097 +TP53 R175L Likely Oncogenic Loss-of-function 15781620, 18762572, 25584008 +TP53 N235D Oncogenic Loss-of-function 25584008 +TP53 V272L Likely Oncogenic Likely Loss-of-function 20407015, 26619011 +TP53 R202S Likely Oncogenic Likely Loss-of-function 10229196 +TP53 T150I Likely Oncogenic Likely Loss-of-function 10229196 +TP53 R280A Likely Oncogenic Likely Loss-of-function 18524770, 24814347, 17189187 +TP53 A161S Likely Oncogenic Loss-of-function 25119136 +TP53 L344R Likely Oncogenic Likely Loss-of-function 19454241, 20978130 +TP53 D186A Likely Oncogenic Likely Loss-of-function 24814347 +TP53 E326L Likely Oncogenic Loss-of-function 26748848 +TP53 R267Q Likely Oncogenic Likely Loss-of-function 10435620, 25584008 +TP53 V218dup Oncogenic Loss-of-function 8023157, 11900253 +TP53 C275S Likely Oncogenic Loss-of-function 25584637 +TP53 L348S Likely Oncogenic Likely Loss-of-function 20978130 +TP53 C242F Likely Oncogenic Likely Loss-of-function 17401432 +TP53 C176F Likely Oncogenic Loss-of-function 22090360 +TP53 H214N Likely Oncogenic Likely Loss-of-function 19462533 +TP53 R267P Likely Oncogenic Likely Gain-of-function 23264849, 22989750 +TP53 C135Y Likely Oncogenic Switch-of-function 22847613 +TP53 G245C Likely Oncogenic Likely Loss-of-function 15037740, 22803791 +TP53 E180K Likely Oncogenic Loss-of-function 24814347, 20471942 +TP53 R273K Likely Oncogenic Loss-of-function 7651437 +TP53 F134Y Likely Oncogenic Likely Loss-of-function 26619011, 25584008 +TP53 P152L Likely Oncogenic Likely Loss-of-function 25584008 +TP53BP1 Truncating Mutations Likely Oncogenic Likely Loss-of-function 23103855 +TP53BP1 Deletion Likely Oncogenic Likely Loss-of-function 16260621, 22915756 +SMAD2 Deletion Likely Oncogenic Loss-of-function 15133179, 20010874, 16382155, 18618014, 12384562, 22204491, 19276350, 20852387 +SMAD2 F346V Likely Neutral Likely Neutral 11274206 +SMAD2 D450E Likely Oncogenic Likely Loss-of-function 23139211 +SMAD2 R310H Likely Oncogenic Likely Loss-of-function 11274206 +SMAD2 T413N Likely Oncogenic Likely Loss-of-function 23139211 +SMAD2 R428A Inconclusive Inconclusive 11779503 +SMAD2 N387P Inconclusive Inconclusive 11779503 +SMAD2 V319D Likely Oncogenic Likely Loss-of-function 11274206 +SMAD2 Y426A Likely Oncogenic Likely Loss-of-function 11779503, 9463378 +SMAD2 K375A Inconclusive Inconclusive 11779503 +SMAD2 S276L Likely Oncogenic Likely Loss-of-function 23139211 +SMAD2 S467P Likely Oncogenic Likely Loss-of-function 23139211 +SMAD2 K420A Likely Oncogenic Likely Loss-of-function 14729957, 11779503 +SMAD2 Y406H Inconclusive Inconclusive 11779503 +SMAD2 W368H Likely Neutral Likely Neutral 11274206, 11779503 +SMAD2 D300H Likely Oncogenic Likely Loss-of-function 11274206, 11779503 +SMAD2 D450H Likely Oncogenic Likely Loss-of-function 11779503 +SMAD2 R321Q Likely Oncogenic Loss-of-function 16828225, 20937913 +SMAD2 P305L Likely Oncogenic Likely Loss-of-function 23139211 +SMAD2 Truncating Mutations Likely Oncogenic Likely Loss-of-function 12894231, 23139211, 15711891, 11779503 +SMAD2 D300N Likely Oncogenic Likely Loss-of-function 23139211 +SMAD3 Truncating Mutations Likely Oncogenic Likely Loss-of-function 11691834 +SMAD3 Y297A Likely Oncogenic Likely Loss-of-function 21949838 +SMAD3 W406A Likely Oncogenic Likely Loss-of-function 21949838 +SMAD3 R292A Likely Oncogenic Likely Loss-of-function 21949838 +SMAD3 K341A Likely Oncogenic Likely Loss-of-function 21949838 +SMAD3 D258N Likely Oncogenic Loss-of-function 23139211 +SMAD3 D408H Likely Oncogenic Loss-of-function 21949838 +SMAD3 Y298A Likely Oncogenic Likely Loss-of-function 21949838 +SMAD3 R268A Likely Oncogenic Loss-of-function 21949838 +SMAD3 Y238A Likely Oncogenic Likely Loss-of-function 21949838 +SMAD3 D408Y Likely Oncogenic Loss-of-function 23139211 +SMAD3 P336S Likely Oncogenic Loss-of-function 23139211 +SMAD3 Deletion Likely Oncogenic Likely Loss-of-function 14647420, 18852474, 9753318, 16951153 +SMAD3 R373H Likely Oncogenic Likely Loss-of-function 16828225 +SMAD3 Y226A Likely Oncogenic Likely Loss-of-function 21949838 +SMAD3 Y237A Likely Neutral Neutral 17994767 +SMAD3 R373Q Likely Oncogenic Loss-of-function 23139211 +SMAD3 R287A Likely Oncogenic Loss-of-function 17994767 +SMAD3 D408E Likely Oncogenic Loss-of-function 10092624 +SMAD3 V356R Likely Oncogenic Likely Loss-of-function 21949838 +SMAD3 S425C Likely Oncogenic Loss-of-function 23139211 +SMAD3 Y384A Likely Oncogenic Likely Loss-of-function 21949838 +SMAD3 E239A Likely Oncogenic Loss-of-function 17994767 +SMAD3 V277D Likely Oncogenic Loss-of-function 10092624 +SMAD3 R243A Likely Oncogenic Likely Loss-of-function 21949838 +SMAD4 P130S Likely Oncogenic Loss-of-function 14647410 +SMAD4 E330A Likely Oncogenic Loss-of-function 17994767 +SMAD4 W398V Inconclusive Inconclusive 11274206 +SMAD4 L43V Likely Oncogenic Likely Loss-of-function 14647410 +SMAD4 C324Y Likely Oncogenic Likely Loss-of-function 22109972 +SMAD4 P102L Likely Oncogenic Likely Loss-of-function 14647410 +SMAD4 R441P Likely Neutral Likely Neutral 11274206, 11779503, 10822381 +SMAD4 Deletion Likely Oncogenic Loss-of-function 22321641, 25893305, 9482899, 10626800, 9506519, 17114584, 19841536, 10773876 +SMAD4 D493H Likely Oncogenic Loss-of-function 11274206, 19139564 +SMAD4 R378A Likely Oncogenic Likely Loss-of-function 15350224 +SMAD4 K507Q Likely Oncogenic Likely Loss-of-function 14647410 +SMAD4 Truncating Mutations Likely Oncogenic Likely Loss-of-function 23139211, 10340381, 15711891, 9094310, 11553622 +SMAD4 E330K Likely Oncogenic Loss-of-function 26488212 +SMAD4 R420H Likely Oncogenic Likely Neutral 11274206, 11779503 +SMAD4 R100T Likely Oncogenic Loss-of-function 14647410, 10092624 +SMAD4 R515A Likely Oncogenic Loss-of-function 11779503 +SMAD4 D357Y Likely Oncogenic Loss-of-function 14715079 +SMAD4 W509R Inconclusive Inconclusive 22316667 +SMAD4 K507A Likely Oncogenic Likely Loss-of-function 11779503 +SMAD4 R515G Likely Oncogenic Loss-of-function 14647410 +SMAD4 G419V Likely Oncogenic Loss-of-function 26488212 +SMAD4 D537E Likely Oncogenic Loss-of-function 9214508, 23139211, 14715079 +SMAD4 Y513A Inconclusive Inconclusive 11779503 +SMAD4 H132Y Likely Oncogenic Likely Loss-of-function 25275298 +SMAD4 E330G Likely Oncogenic Likely Loss-of-function 22316667 +SMAD4 R361C Likely Oncogenic Loss-of-function 9214508, 14647410, 26488212, 10092624 +SMAD4 K428A Likely Oncogenic Likely Loss-of-function 11779503 +SMAD4 D537Y Oncogenic Loss-of-function 23139211, 14715079 +SMAD4 V370D Likely Oncogenic Likely Loss-of-function 9214508, 11274206, 10092624, 19139564, 11779503 +SMAD4 R497H Likely Oncogenic Loss-of-function 14647410 +SMAD4 Y353L Likely Oncogenic Likely Loss-of-function 26619011 +SMAD4 D351H Likely Oncogenic Loss-of-function 9214508, 14647410, 11274206, 11779503, 14715079 +SMAD4 G508S Likely Oncogenic Likely Loss-of-function 9214508, 9153220 +SMAD4 D493A Likely Oncogenic Likely Loss-of-function 15350224 +SMAD4 R496H Likely Oncogenic Loss-of-function 26488212 +SMAD4 A532H Likely Oncogenic Loss-of-function 11274206 +SMAD4 V465M Inconclusive Inconclusive 22316667 +CDK4 R24C Oncogenic Gain-of-function 11606789, 11756559 +CDK4 Amplification Oncogenic Gain-of-function 20534551, 8101826, 10970848 +CDK4 K22A Oncogenic Gain-of-function 9426066, 9712735, 9228064 +AURKB Overexpression Likely Oncogenic Likely Gain-of-function 17344846, 26240282, 18347165, 16222316 +AURKB Amplification Likely Oncogenic Likely Gain-of-function 26240282 +CDK6 Amplification Oncogenic Gain-of-function 17989712, 23127611, 11940479, 20534551, 24736461, 22476749, 12900351, 19145199, 24764564 +CDK6 A197T Likely Neutral Loss-of-function 23918663 +FBXW7 G423R Likely Oncogenic Likely Loss-of-function 24838835, 26619011 +FBXW7 R505L Oncogenic Loss-of-function 17646409 +FBXW7 K11R Likely Oncogenic Likely Loss-of-function 20815813 +FBXW7 S462Y Likely Neutral Likely Neutral 27147599 +FBXW7 R465H Likely Oncogenic Loss-of-function 27147599, 24912918, 23228967, 17575125, 22608923 +FBXW7 D520N Likely Oncogenic Likely Loss-of-function 11565034, 19420964 +FBXW7 S562L Likely Neutral Neutral 24838835 +FBXW7 Truncating Mutations Likely Oncogenic Likely Loss-of-function 17646409, 15103331, 18094723 +FBXW7 R505C Oncogenic Loss-of-function 27147599, 17646408, 17575125, 23228967, 24838835, 22608923, 23095493 +FBXW7 S227A Likely Oncogenic Loss-of-function 21620836 +FBXW7 Deletion Likely Oncogenic Likely Loss-of-function 25314076, 27764699, 18367647, 15103331 +FBXW7 R479H Likely Oncogenic Loss-of-function 17575125 +FBXW7 R658Q Likely Oncogenic Likely Loss-of-function 27147599, 26619011 +FBXW7 I347M Likely Neutral Likely Neutral 27147599 +FBXW7 T205A Likely Neutral Likely Gain-of-function 22608923 +FBXW7 R465C Oncogenic Loss-of-function 17646408, 17909001, 17646409, 23095493 +FBXW7 R479Q Oncogenic Loss-of-function 17646408, 17909001, 23228967, 17646409 +FBXW7 R689Q Likely Oncogenic Likely Loss-of-function 27147599, 26619011 +FBXW7 R479L Likely Oncogenic Loss-of-function 24912918, 22608923 +FBXW7 R482Q Oncogenic Loss-of-function 23676439 +FBXW7 Copy Number Loss Oncogenic Loss-of-function 19739118, 24884509, 18367647, 18094723, 25555218, 22673505 +CDK8 Amplification Oncogenic Gain-of-function 18794900 +CDKN1A S31R Inconclusive Inconclusive 7655464, 20127253, 18046503, 17293864 +CDKN1A Truncating Mutations Likely Oncogenic Likely Loss-of-function 23159848, 24317508 +CDKN1A Deletion Likely Oncogenic Likely Loss-of-function 19106607, 25483104, 23624841, 15960923 +CDKN1B Deletion Oncogenic Loss-of-function 8646779, 23460367, 18073348, 21422114 +CDKN1B P133T Likely Oncogenic Likely Loss-of-function 21289244 +CDKN1B Truncating Mutations Likely Oncogenic Likely Loss-of-function 23555276, 8646779, 22129891, 21423803, 20492666, 25416039 +CDKN1B G9R Likely Oncogenic Loss-of-function 21289244 +CDKN1B V109G Inconclusive Inconclusive 22823061, 23652671 +CDKN2A D74N Oncogenic Loss-of-function 10491434, 19260062 +CDKN2A P81T Oncogenic Loss-of-function 20340136, 19260062, 10389768 +CDKN2A E69G Oncogenic Loss-of-function 20340136, 19260062 +CDKN2A D108H Likely Oncogenic Likely Loss-of-function 12606942 +CDKN2A D84V Oncogenic Loss-of-function 10491434 +CDKN2A R79P Oncogenic Loss-of-function 7647780 +CDKN2A R87W Oncogenic Loss-of-function 10491434, 19260062 +CDKN2A N71I Oncogenic Loss-of-function 20340136 +CDKN2A R112G Oncogenic Loss-of-function 20340136 +CDKN2A Deletion Oncogenic Loss-of-function 24071852, 9516223 +CDKN2A P81L Oncogenic Loss-of-function 20340136, 19260062, 10389768 +CDKN2A L32P Oncogenic Loss-of-function 20340136 +CDKN2A H83N Likely Oncogenic Loss-of-function 9660926 +CDKN2A N71S Oncogenic Loss-of-function 10491434 +CDKN2A L97R Oncogenic Loss-of-function 20340136, 19260062 +CDKN2A L16P Oncogenic Loss-of-function 20340136 +CDKN2A P114L Oncogenic Loss-of-function 19260062, 8755727 +CDKN2A G35A Likely Oncogenic Loss-of-function 20340136, 19260062 +CDKN2A D84H Likely Oncogenic Loss-of-function 8755727, 10498896 +CDKN2A A60R Oncogenic Loss-of-function 20340136, 19260062 +CDKN2A T77P Oncogenic Loss-of-function 19260062 +CDKN2A S56I Oncogenic Loss-of-function 20340136 +CDKN2A P73L Oncogenic Loss-of-function 7647780 +CDKN2A R99P Oncogenic Loss-of-function 20340136, 19260062 +CDKN2A G101W Oncogenic Loss-of-function 10491434, 20340136, 19260062, 8755727 +CDKN2A Q50P Oncogenic Loss-of-function 14508519 +CDKN2A G67S Oncogenic Loss-of-function 20340136, 19260062 +CDKN2A R80L Oncogenic Loss-of-function 10491434 +CDKN2A R80P Likely Oncogenic Likely Loss-of-function 10491434 +CDKN2A Q50* Oncogenic Loss-of-function 7987387 +CDKN2A R87P Oncogenic Loss-of-function 10491434, 19260062, 9607312 +CDKN2A D84Y Oncogenic Loss-of-function 10498896 +CDKN2A H83Y Oncogenic Loss-of-function 10491434, 9324288 +CDKN2A N71K Oncogenic Loss-of-function 20340136 +CDKN2A Truncating Mutations Likely Oncogenic Likely Loss-of-function 20340136, 9324288, 8603820 +CDKN2A A60V Likely Oncogenic Loss-of-function 20340136, 19260062 +CDKN2A D84N Likely Oncogenic Loss-of-function 8755727, 7777061, 10498896 +CDKN2A G35V Likely Oncogenic Loss-of-function 20340136, 19260062 +CDKN2A M53I Oncogenic Loss-of-function 20340136, 19260062 +CDKN2A A148T Inconclusive Inconclusive 15879498, 8603820, 7647780 +CDKN2A R87L Oncogenic Loss-of-function 10491434, 9607312 +CDKN2A A57V Oncogenic Loss-of-function 19260062 +CDKN2A D74Y Likely Oncogenic Loss-of-function 10491434, 19260062 +CDKN2A D108N Likely Oncogenic Likely Loss-of-function 12417717 +CDKN2A A36P Oncogenic Loss-of-function 20340136 +CDKN2A V118D Oncogenic Loss-of-function 7647780 +CDKN2A G93W Likely Oncogenic Loss-of-function 7647780 +CDKN2A I49S Oncogenic Loss-of-function 20340136 +CDKN2A D84G Oncogenic Loss-of-function 10491434 +CDKN2A E88K Oncogenic Loss-of-function 10498896 +CDKN2A A68T Oncogenic Loss-of-function 20340136 +CDKN2A V126D Oncogenic Loss-of-function 20340136 +CDKN2A G35R Likely Oncogenic Loss-of-function 20340136, 19260062 +CDKN2A G67R Oncogenic Loss-of-function 20340136, 19260062 +CDKN2A G23D Oncogenic Loss-of-function 20340136, 19260062 +CDKN2A P114S Oncogenic Loss-of-function 19260062, 8755727 +CDKN2A P48L Oncogenic Loss-of-function 10491434 +CDKN2A R24P Oncogenic Loss-of-function 20340136 +CDKN2B Truncating Mutations Likely Oncogenic Likely Loss-of-function 12032783, 9479825, 11485924 +CDKN2B E35* Oncogenic Loss-of-function 25873077 +CDKN2B D86N Oncogenic Loss-of-function 23715670, 25873077 +CDKN2B Hypermethylation Oncogenic Loss-of-function 19064397, 17489980 +CDKN2B P40T Oncogenic Loss-of-function 25873077 +CDKN2B A23E Oncogenic Loss-of-function 25873077 +CDKN2B Deletion Oncogenic Loss-of-function 12032783, 8078588, 9479825 +CDKN2C Deletion Likely Oncogenic Likely Loss-of-function 18829482, 21994415 +CDKN2C Truncating Mutations Likely Oncogenic Likely Loss-of-function +ASXL1 Deletion Likely Oncogenic Likely Loss-of-function 24255920, 22897849, 24218140 +ASXL1 Truncating Mutations Likely Oncogenic Likely Loss-of-function 19388938, 24216483, 22897849, 21455215, 26095772 +ERBB2 G309A Oncogenic Gain-of-function 23220880, 22908275 +ERBB2 Y1248F Likely Neutral Loss-of-function 1671296 +ERBB2 D808N Likely Oncogenic Likely Gain-of-function 25435280 +ERBB2 Y803N Inconclusive Inconclusive 18413839 +ERBB2 G776S Likely Oncogenic Gain-of-function 18039657 +ERBB2 G292R Likely Oncogenic Likely Gain-of-function 24997986 +ERBB2 Y772_A775dup Oncogenic Gain-of-function 23220880, 16843263, 22908275 +ERBB2 D769A Likely Neutral Loss-of-function 23843458 +ERBB2 T216S Likely Neutral Likely Neutral 22908275, 18772396, 18772890 +ERBB2 G660D Likely Oncogenic Gain-of-function 24317180, 26545934 +ERBB2 N857S Likely Oncogenic Likely Gain-of-function 22046346 +ERBB2 T798M Likely Oncogenic Likely Gain-of-function 22046346 +ERBB2 R896C Oncogenic Gain-of-function 23220880 +ERBB2 Amplification Oncogenic Gain-of-function 23204226, 12124352, 2885917, 24656976, 10716706, 11571643 +ERBB2 C311R Oncogenic Gain-of-function 22908275, 18772890 +ERBB2 G778_P780dup Oncogenic Gain-of-function 23220880 +ERBB2 R143Q Likely Neutral Likely Neutral 24971884 +ERBB2 N319D Likely Neutral Likely Neutral 22908275, 18772396, 18772890, 23389443 +ERBB2 E321G Oncogenic Gain-of-function 22908275, 18772890 +ERBB2 S310Y Oncogenic Gain-of-function 24516025, 24997986, 22908275, 26358791 +ERBB2 M774_A775insAYVM Oncogenic Gain-of-function 17311002 +ERBB2 L726I Likely Oncogenic Gain-of-function 17638894 +ERBB2 Exon 20 insertions/deletions Oncogenic Gain-of-function 16775247, 23220880, 16843263, 23610105, 21353324, 22649146, 22325357, 25899785 +ERBB2 L785F Inconclusive Inconclusive 18413839 +ERBB2 C630Y Inconclusive Inconclusive 18413839 +ERBB2 L726F Likely Oncogenic Likely Gain-of-function 18413839, 25435280 +ERBB2 L869R Likely Oncogenic Likely Gain-of-function 21531810, 26305917, 16397024 Hyman et al. Abstract# PD5-05, AACR 2016 http://cancerres.aacrjournals.org/content/76/4_Supplement/PD5-05 +ERBB2 L755S Oncogenic Gain-of-function 22046346, 18413839, 23220880 +ERBB2 V842I Oncogenic Gain-of-function 24997986, 23220880 +ERBB2 E265K Likely Oncogenic Likely Gain-of-function 24997986 +ERBB2 L915M Inconclusive Inconclusive 18413839 +ERBB2 S653C Oncogenic Gain-of-function 24971884 +ERBB2 D769H Oncogenic Gain-of-function 23220880, 23843458 +ERBB2 V773A Likely Oncogenic Likely Gain-of-function 22046346, 26619011, 16299242 +ERBB2 D769Y Oncogenic Gain-of-function 23220880 +ERBB2 D821N Likely Oncogenic Likely Gain-of-function 18413839 +ERBB2 G309E Oncogenic Gain-of-function 22908275 +ERBB2 V794M Likely Oncogenic Likely Gain-of-function 25435280 +ERBB2 S760A Likely Neutral Likely Neutral 23220880 +ERBB2 E719K Inconclusive Inconclusive 18413839 +ERBB2 L755_T759del Oncogenic Gain-of-function 23220880, 15118073, 15329413, 15118125 +ERBB2 E717K Inconclusive Inconclusive 18413839 +ERBB2 G776delinsLC Oncogenic Gain-of-function 26545934 +ERBB2 C334S Oncogenic Gain-of-function 22908275, 18772890 +ERBB2 Exon 20 insertions Oncogenic Gain-of-function 16775247, 23220880, 16843263, 23610105, 21353324, 22649146, 22325357, 25899785 +ERBB2 K753A Likely Neutral Loss-of-function 22393464, 23680147 +ERBB2 V750E Likely Neutral Likely Neutral 22908275, 18772396, 18772890, 23389443 +ERBB2 L49H Likely Neutral Likely Neutral 22908275, 18772396, 18772890, 23389443 +ERBB2 S783P Inconclusive Inconclusive 18413839 +ERBB2 H878Y Likely Oncogenic Gain-of-function 22046346, 25853726 +ERBB2 D277H Likely Oncogenic Likely Gain-of-function 24971884 +ERBB2 K753E Inconclusive Inconclusive 27697991 +ERBB2 S310F Oncogenic Gain-of-function 24516025, 24997986, 22908275, 26358791 +ERBB2 S335C Likely Oncogenic Likely Gain-of-function 23630663 +ERBB2 V777M Likely Neutral Likely Neutral 18039657, 25720673 +ERBB2 A775_G776insYVMA Oncogenic Gain-of-function 17311002 +ERBB2 V777L Oncogenic Gain-of-function 24516025, 22046346, 23220880 +ERBB2 V777A Likely Oncogenic Likely Gain-of-function 26619011, 22908275, 18772396, 18772890, 23389443 +ERBB2 Y835F Likely Neutral Likely Loss-of-function 23220880 +ERBB2 I767M Oncogenic Gain-of-function 25994018, 23220880 +ERBB2 D845A Likely Neutral Loss-of-function 22908275 +ERBB2 P780L Likely Oncogenic Likely Gain-of-function 18413839 +ERBB2 S1002R Inconclusive Inconclusive 18413839 +ERBB2 L866M Oncogenic Gain-of-function 26243863 +ERBB2 T862A Oncogenic Gain-of-function 22046346 +ERBB2 T733I Likely Oncogenic Likely Gain-of-function 18413839, 16397024 +ERBB2 E719G Inconclusive Inconclusive 18413839 +ERBB2 E812K Inconclusive Inconclusive 18413839 +ERBB2 K753M Likely Neutral Loss-of-function 16489002 +ERBB2 T798I Likely Oncogenic Likely Switch-of-function 18413839, 28274957 +ERBB2 R678Q Likely Oncogenic Likely Gain-of-function 24971884, 23220880 +ERBB2 V839G Inconclusive Inconclusive 18413839 +ERBB2 L755P Oncogenic Gain-of-function 22046346 +ERBB2 G776_V777insYVMA Oncogenic Gain-of-function 16843263 +ERBB2 V659E Oncogenic Gain-of-function 1671296, 7821711 +ERBB2 G776delinsVC Oncogenic Gain-of-function 26545934 +ERBB3 V104M Oncogenic Gain-of-function 23680147 +ERBB3 P262H Oncogenic Gain-of-function 23680147 +ERBB3 A232V Oncogenic Gain-of-function 23680147 +ERBB3 T389K Oncogenic Gain-of-function 23680147 +ERBB3 S846I Oncogenic Gain-of-function 23680147 +ERBB3 Q809R Oncogenic Gain-of-function 23680147 +ERBB3 R669C Inconclusive Inconclusive 23741632 +ERBB3 Amplification Oncogenic Gain-of-function 20418034, 24886126, 25739551 +ERBB3 G284R Oncogenic Gain-of-function 23680147 +ERBB3 V104L Oncogenic Gain-of-function 23680147 +ERBB3 E928G Oncogenic Gain-of-function 23680147 +ERBB3 V714M Likely Neutral Likely Neutral 23680147 +ERBB3 A1131T Inconclusive Inconclusive 23741632 +ERBB4 E542K Oncogenic Gain-of-function 19718025 +ERBB4 G936R Inconclusive Inconclusive 21701703 +ERBB4 K935I Oncogenic Gain-of-function 26050618 +ERBB4 E872K Oncogenic Gain-of-function 19718025 +ERBB4 H618P Likely Neutral Neutral 26050618 +ERBB4 EZR-ERBB4 Fusion Oncogenic Gain-of-function 24727320, 22327623 +ERBB4 M887I Inconclusive Inconclusive 25435280 +ERBB4 T244R Likely Neutral Neutral 26050618 +ERBB4 D595V Oncogenic Gain-of-function 26050618 +ERBB4 E452K Oncogenic Gain-of-function 19718025 +ERBB4 D931Y Likely Oncogenic Gain-of-function 26050618 +ERBB4 Fusions Likely Oncogenic Likely Gain-of-function 24727320 +ERBB4 G785S Inconclusive Inconclusive 25435280 +ERBB4 N181S Likely Neutral Neutral 26050618 +ERBB4 V348L Likely Neutral Neutral 26050618 +ERBB4 R544W Oncogenic Gain-of-function 19718025 +ERBB4 R306S Likely Oncogenic Gain-of-function 26050618 +ERBB4 E317K Oncogenic Gain-of-function 19718025 +ERBB4 E836K Oncogenic Gain-of-function 19718025 +ERBB4 Y285C Oncogenic Gain-of-function 26050618 +ERBB4 E563K Oncogenic Gain-of-function 19718025 +ERBB4 R838Q Inconclusive Inconclusive 25435280 +ERCC2 D513Y Likely Oncogenic Likely Loss-of-function 27504877 +ERCC2 D423N Likely Oncogenic Likely Loss-of-function 27504877 +ERCC2 R631C Likely Oncogenic Likely Loss-of-function 27504877 +ERCC2 N238S Likely Oncogenic Likely Loss-of-function 25096233 +ERCC2 R487W Likely Oncogenic Likely Loss-of-function 27504877 +ERCC2 L461V Likely Oncogenic Likely Loss-of-function 27504877 +ERCC2 D609E Likely Oncogenic Likely Loss-of-function 25096233 +ERCC2 F568fs Likely Oncogenic Likely Loss-of-function 27504877 +ERCC2 G665A Likely Oncogenic Likely Loss-of-function 25096233 +ERCC2 A717G Likely Oncogenic Likely Loss-of-function 27504877 +ERCC2 R592H Likely Neutral Likely Neutral 27504877 +ERCC2 P463L Likely Oncogenic Likely Loss-of-function 25096233 +ERCC2 R450H Likely Neutral Likely Neutral 27504877 +ERCC2 V242F Likely Oncogenic Likely Loss-of-function 25096233 +ERCC2 Y24C Likely Oncogenic Likely Loss-of-function 25096233 +ERCC2 D609G Likely Oncogenic Likely Loss-of-function 25096233 +ERCC2 Amplification Likely Oncogenic Likely Gain-of-function 25096233 +ERCC2 S746fs Likely Oncogenic Likely Loss-of-function 27504877 +ERCC2 Truncating Mutations Likely Oncogenic Likely Loss-of-function +ERCC2 E606G Likely Oncogenic Likely Loss-of-function 25096233 +ERCC2 R601Q Likely Oncogenic Likely Loss-of-function 27504877 +ERCC2 V536M Likely Oncogenic Likely Loss-of-function 27504877 +BRIP1 Truncating Mutations Likely Oncogenic Likely Loss-of-function 16153896, 24040146, 17033622, 21964575, 18628483 +BRIP1 M299I Inconclusive Inconclusive 17145708, 11301010, 14983014 +BRIP1 R173C Oncogenic Loss-of-function 12569564 +BRIP1 R798* Likely Oncogenic Likely Loss-of-function 16153896, 17033622 +BRIP1 K52R Oncogenic Loss-of-function 11301010, 2846277, 8196650, 14983014 +BRIP1 A349P Likely Oncogenic Likely Loss-of-function 20639400, 16116424 +BRIP1 P47A Oncogenic Loss-of-function 11301010, 14983014 +BRIP1 Deletion Likely Oncogenic Likely Loss-of-function 24040146, 21964575, 18628483 +ERCC3 R109* Likely Oncogenic Loss-of-function 27655433 +ERCC3 Truncating Mutations Likely Oncogenic Likely Loss-of-function 16143348, 19942596, 27655433, 8196650 +ERCC4 S786F Oncogenic Loss-of-function 24027083 +ERCC4 Deletion Likely Oncogenic Likely Loss-of-function 9580660, 26074087, 23623386 +ERCC4 E875G Oncogenic Loss-of-function 10499592 +ERCC4 L230P Oncogenic Loss-of-function 23623386 +ERCC4 Truncating Mutations Likely Oncogenic Likely Loss-of-function 9580660, 8887684 +ERCC4 R689S Oncogenic Loss-of-function 24027083, 23623386 +ABL1 M351T Likely Oncogenic Likely Gain-of-function 16046538, 21562040 +ABL1 Y253H Likely Oncogenic Likely Gain-of-function 16482207 +ABL1 E355A Likely Oncogenic Likely Gain-of-function 24456693 +ABL1 Fusions Likely Oncogenic Likely Gain-of-function 21435002 +ABL1 Y253F Oncogenic Gain-of-function 16880519 +ABL1 E459K Likely Oncogenic Likely Gain-of-function 19201023 +ABL1 V299L Likely Oncogenic Likely Gain-of-function 23086624, 18242697 +ABL1 F311L Likely Oncogenic Likely Gain-of-function 21562040 +ABL1 H396P Likely Oncogenic Likely Gain-of-function 21562040, 16424036 +ABL1 L248V Likely Oncogenic Likely Gain-of-function 21562040 +ABL1 F359C Likely Oncogenic Likely Gain-of-function 19798095 +ABL1 L384M Likely Oncogenic Likely Gain-of-function 21562040 +ABL1 L387M Likely Oncogenic Likely Gain-of-function 21562040 +ABL1 D276G Oncogenic Gain-of-function 15510211 +ABL1 E255V Likely Oncogenic Likely Gain-of-function 21562040 +ABL1 F317L Likely Oncogenic Likely Gain-of-function 21562040 +ABL1 E355G Likely Oncogenic Likely Gain-of-function 21562040 +ABL1 F359V Likely Oncogenic Likely Gain-of-function 21562040 +ABL1 T315I Likely Oncogenic Likely Gain-of-function 18794843, 11423618 +ABL1 V379I Likely Oncogenic Likely Gain-of-function 21562040 +ABL1 E279K Likely Oncogenic Likely Gain-of-function 21562040 +ABL1 Q252H Likely Oncogenic Likely Gain-of-function 16046538, 21562040 +ABL1 V289F Likely Oncogenic Likely Gain-of-function 23355941 +ABL1 G250E Likely Oncogenic Likely Gain-of-function 21562040 +ABL1 BCR-ABL1 Fusion Oncogenic Gain-of-function 11345193, 18851712 +ABL1 E281K Likely Oncogenic Likely Gain-of-function 21193419 +ABL1 E255K Likely Oncogenic Likely Gain-of-function 15194504 +ABL1 H396R Likely Oncogenic Likely Gain-of-function 21562040 +ABL1 M244V Likely Oncogenic Likely Gain-of-function 21562040 +CEBPA Truncating Mutations Likely Oncogenic Likely Loss-of-function 11830484, 19322763, 19651529, 18768433, 19075268 +ERF Truncating Mutations Likely Oncogenic Likely Loss-of-function 21548782, 17699159, 17525531, 22198386 +ERG Fusions Likely Oncogenic Likely Gain-of-function 19649210, 23625457, 20585344 +ERG TMPRSS2-ERG Fusion Oncogenic Gain-of-function 22142399, 19396167, 18283340, 17043636 +ERG FUS-ERG Fusion Oncogenic Gain-of-function 8187069, 7970732, 9653171, 25453903 +ERG EWSR1-ERG Fusion Oncogenic Gain-of-function 16357154, 8162068, 25453903 +HLA-A Truncating Mutations Likely Oncogenic Likely Loss-of-function 15546342 +HLA-A 596_619splice Likely Oncogenic Likely Loss-of-function 16216676 +HLA-B Truncating Mutations Likely Oncogenic Likely Loss-of-function 26889905, 19845903, 27807939, 14675390, 28205408 +PDGFRA D1071N Likely Neutral Neutral 23752188 +PDGFRA H845Y Likely Oncogenic Gain-of-function 24132921 +PDGFRA Fusions Likely Oncogenic Likely Gain-of-function 20889717 +PDGFRA V658A Likely Oncogenic Gain-of-function 24132921 +PDGFRA N659K Likely Oncogenic Gain-of-function 15928335 +PDGFRA C456_N468del Oncogenic Gain-of-function 23970477 +PDGFRA C456_R481del Oncogenic Gain-of-function 23970477 +PDGFRA V561_I562insER Oncogenic Gain-of-function 15928335, 12522257 +PDGFRA N870S Likely Neutral Neutral 23752188 +PDGFRA H570R Likely Neutral Neutral 21224473 +PDGFRA BCR-PDGFRA Fusion Likely Oncogenic Gain-of-function 12023981, 12944919, 15034867 +PDGFRA I843del Likely Oncogenic Gain-of-function 22745105 +PDGFRA I834V Likely Neutral Neutral 24132921 +PDGFRA KDR-PDGFRA Fusion Oncogenic Gain-of-function 20889717, 16690743 +PDGFRA FIP1L1-PDGFRA Fusion Oncogenic Gain-of-function 16754777, 19187542, 16645167, 24057647, 12660384, 16690743, 24407160, 16608506, 21224473, 19212337, 12781364, 27021554, 16030188 +PDGFRA W349C Likely Neutral Likely Loss-of-function 23752188 +PDGFRA T674I Likely Oncogenic Likely Gain-of-function 22745105 +PDGFRA E996K Likely Neutral Neutral 23752188 +PDGFRA P577S Likely Oncogenic Gain-of-function 24132921 +PDGFRA Y555C Likely Oncogenic Gain-of-function 25975287, 17087943 +PDGFRA CDK5RAP2-PDGFRA Fusion Oncogenic Gain-of-function 16845659 +PDGFRA V544_L545insAVLVLLVIVIISLI Oncogenic Gain-of-function 23970477 +PDGFRA A633T Likely Oncogenic Likely Gain-of-function 24132921 +PDGFRA E311_K312del Oncogenic Gain-of-function 23970477 +PDGFRA P130S Likely Neutral Likely Neutral 23752188 +PDGFRA I562M Likely Neutral Neutral 21224473 +PDGFRA H845_N848delinsP Oncogenic Gain-of-function 15928335, 12522257, 22745105 +PDGFRA H650Q Oncogenic Gain-of-function 21224473 +PDGFRA S478P Likely Neutral Likely Neutral 22733151, 12949711, 19366796 +PDGFRA N659R Likely Oncogenic Gain-of-function 15928335 +PDGFRA V561D Oncogenic Gain-of-function 17087936, 12949711, 15928335, 19217431, 12522257, 18955458, 22665524, 22745105 +PDGFRA C450_K451insMIEWMI Oncogenic Gain-of-function 23970477 +PDGFRA V561A Oncogenic Likely Gain-of-function 24132921 +PDGFRA N659S Likely Oncogenic Gain-of-function 21224473 +PDGFRA ETV6-PDGFRA Fusion Oncogenic Gain-of-function 17555450 +PDGFRA KIF5B-PDGFRA Fusion Oncogenic Gain-of-function 17555450, 16498388 +PDGFRA Q579R Likely Oncogenic Gain-of-function 24132921 +PDGFRA D842_H845del Likely Oncogenic Gain-of-function 22745105 +PDGFRA V536E Oncogenic Gain-of-function 23752188 +PDGFRA D842Y Likely Oncogenic Gain-of-function 15928335, 24132921, 22745105 +PDGFRA F808L Likely Neutral Loss-of-function 23752188 +PDGFRA D842_I843delinsIM Oncogenic Gain-of-function 15928335, 22745105 +PDGFRA S566_E571delinsR Likely Oncogenic Gain-of-function 15928335, 12522257 +PDGFRA A633V Likely Neutral Neutral 24132921 +PDGFRA R481G Likely Neutral Likely Neutral 21224473 +PDGFRA 560_561insER Oncogenic Gain-of-function 22745105 +PDGFRA D842I Likely Oncogenic Gain-of-function 15928335, 22745105 +PDGFRA Y375_K455del Oncogenic Gain-of-function 20889717, 12569364 +PDGFRA Y849S Likely Oncogenic Gain-of-function 21224473 +PDGFRA G829R Likely Neutral Neutral 23752188 +PDGFRA Y849C Likely Oncogenic Gain-of-function 15146165, 15928335 +PDGFRA R841K Oncogenic Gain-of-function 24132921 +PDGFRA L507P Likely Neutral Likely Neutral 24057647, 21224473 +PDGFRA D846Y Likely Oncogenic Gain-of-function 15928335, 22745105 +PDGFRA Amplification Oncogenic Gain-of-function 21931021, 20685895, 18772890, 22745105, 16357008 +PDGFRA W559_R560del Oncogenic Gain-of-function 26396737 +PDGFRA S584L Likely Oncogenic Gain-of-function 24132921 +PDGFRA D842V Oncogenic Gain-of-function 24132921, 22665524, 23752188, 18794084, 17087936, 12949711, 15928335, 23970477, 19217431, 12522257, 18955458, 22745105, 15685537, 16030188 +PDGFRA D568N Likely Oncogenic Gain-of-function 24132921 +PDGFRA K830R Likely Neutral Neutral 24132921 +PDGFRA N848K Likely Oncogenic Gain-of-function 15928335 +PDGFRA I843_D846del Likely Oncogenic Gain-of-function 18955458, 22745105 +PDGFRA R748G Oncogenic Gain-of-function 21224473 +PDGFRA STRN-PDGFRA Fusion Oncogenic Gain-of-function 17555450 +PDGFRA G853D Oncogenic Gain-of-function 24132921 +PDGFRA D842_M844del Likely Oncogenic Gain-of-function 18794084 +PDGFRA V469A Likely Oncogenic Likely Gain-of-function 23752188 +PDGFRB GIT2-PDGFRB Fusion Likely Oncogenic Likely Gain-of-function 17296564, 18262053 +PDGFRB KIAA1509-PDGFRB Fusion Likely Oncogenic Likely Gain-of-function 12907457 +PDGFRB SPTBN1-PDGFRB Fusion Likely Oncogenic Likely Gain-of-function 18262053 +PDGFRB NIN-PDGFRB Fusion Likely Oncogenic Likely Gain-of-function 15087377 +PDGFRB R561C Inconclusive Inconclusive 23731537 +PDGFRB HIP1-PDGFRB Fusion Oncogenic Gain-of-function 9616134 +PDGFRB RABEP1-PDGFRB Fusion Oncogenic Gain-of-function 11588050 +PDGFRB Amplification Inconclusive Inconclusive 18515258, 18157090, 18612157, 16630177, 21729646, 18670317 +PDGFRB ATF7IP-PDGFRB Fusion Likely Oncogenic Likely Gain-of-function 8168137 +PDGFRB TP53BP1-PDGFRB Fusion Likely Oncogenic Likely Gain-of-function 15492236 +PDGFRB PRKG2-PDGFRB Fusion Likely Oncogenic Likely Gain-of-function 17296564, 18262053 +PDGFRB L658P Likely Neutral Loss-of-function 23255827, 26599395 +PDGFRB E1071W Likely Neutral Likely Loss-of-function 23255827, 26599395 +PDGFRB P660T Inconclusive Inconclusive 23731542 +PDGFRB PDE4DIP-PDGFRB Fusion Likely Oncogenic Likely Gain-of-function 12907457 +PDGFRB ETV6-PDGFRB Fusion Oncogenic Gain-of-function 22271894, 8168137, 19644140, 19100521 +PDGFRB KANK1-PDGFRB Fusion Oncogenic Gain-of-function 21685469 +PDGFRB GOLGA4-PDGFRB Fusion Likely Oncogenic Likely Gain-of-function 20085582 +PDGFRB R987W Likely Neutral Likely Loss-of-function 23255827, 26599395 +PDGFRB WDR48-PDGFRB Fusion Likely Oncogenic Likely Gain-of-function 20085582 +PDGFRB Fusions Likely Oncogenic Likely Gain-of-function 20581310, 8962143, 19806146, 22271894, 8168137, 22897847, 18483217 +PDGFRB EBF1-PDGFRB Fusion Oncogenic Gain-of-function 24186319, 8168137, 22897847, 23835704 +PDGFRB GPIAP1-PDGFRB Fusion Likely Oncogenic Likely Gain-of-function 17296564 +PDGFRB V665A Oncogenic Loss-of-function 26279204 +PDGFRB BIN2-PDGFRB Fusion Likely Oncogenic Likely Gain-of-function 20085582 +PDGFRB CEP85L-PDGFRB Fusion Oncogenic Likely Gain-of-function 23186533, 15492236 +RBM10 Deletion Likely Oncogenic Likely Loss-of-function 26853560, 24000153, 24332178 +RBM10 V354E Oncogenic Loss-of-function 20007775, 24332178 +RBM10 Truncating Mutations Likely Oncogenic Likely Loss-of-function 21910224, 24000153, 22980975, 25079552, 24332178 +KDM5C M1_E165DEL Likely Oncogenic Loss-of-function 25666439 +KDM5C P480L Likely Oncogenic Loss-of-function 25666439 +KDM5C D402Y Likely Oncogenic Loss-of-function 25666439 +KDM5C Overexpression Likely Oncogenic Likely Gain-of-function 25016185 +KDM5C Truncating Mutations Likely Oncogenic Likely Loss-of-function +KDM5C V1075Yfs*2 Likely Oncogenic Loss-of-function 25666439 +ESR1 V534E Likely Neutral Neutral 27986707 +ESR1 Y537N Likely Oncogenic Gain-of-function 24185512, 24398047, 24185510, 9102207, 11322512, 9500442 +ESR1 L536P Likely Oncogenic Gain-of-function 10787412, 9234721, 1630819, 9774463, 15282324 +ESR1 A546D Oncogenic Gain-of-function 27986707 +ESR1 Y537S Oncogenic Gain-of-function 24185512, 24185510, 26836308, 27986707, 8923465, 9398213, 11914066 +ESR1 ESR1-CCDC170 Fusion Oncogenic Gain-of-function 25099679, 22496636, 22101766 +ESR1 V422del Likely Oncogenic Gain-of-function 27986707 +ESR1 ESR1-YAP1 Fusion Oncogenic Gain-of-function 24055055 +ESR1 S432L Likely Neutral Neutral 27986707 +ESR1 D538G Oncogenic Gain-of-function 24185512, 24398047, 24185510, 24217577, 1630819, 26836308, 15282324 +ESR1 L536R Likely Oncogenic Gain-of-function 24185512, 1630819, 15282324 +ESR1 E380Q Likely Oncogenic Gain-of-function 9259327, 1630819, 8114756, 15282324 +ESR1 S463P Likely Oncogenic Likely Gain-of-function 24185512, 1630819, 15282324 +ESR1 L536Q Likely Oncogenic Gain-of-function 24185510, 1630819, 15282324 +ESR1 L536H Likely Oncogenic Gain-of-function 1630819, 15282324, 15159406 +ESR1 Y537C Likely Oncogenic Gain-of-function 24398047, 24185510, 1630819, 11322512, 9500442, 15282324 +ESR1 L469V Likely Oncogenic Gain-of-function 1630819, 27986707, 15282324 +ESR1 Fusions Likely Oncogenic Likely Gain-of-function 25099679, 24055055 +ETV1 EWSR1-ETV1 Fusion Oncogenic Gain-of-function 16357154, 7700648, 25453903 +ETV1 Amplification Oncogenic Gain-of-function 23908683, 20160028 +ETV1 Fusions Likely Oncogenic Likely Gain-of-function 23814484, 21298110, 18794142, 23625457, 17671502 +ETV1 TMPRSS2-ETV1 Fusion Oncogenic Gain-of-function 18563191, 23512661 +ETV6 R369W Likely Oncogenic Likely Loss-of-function 25581430, 26522332, 27365488 +ETV6 R418G Likely Oncogenic Loss-of-function 25807284 +ETV6 ETV6-NTRK3 Fusion Oncogenic Gain-of-function 21804605, 18068631, 21148487 +ETV6 385_418del Likely Oncogenic Loss-of-function 25807284 +ETV6 R369Q Likely Oncogenic Likely Loss-of-function 25581430, 26522332, 26102509, 27365488 +ETV6 ETV6-FLT3 Fusion Oncogenic Gain-of-function 16761019 +ETV6 P214L Likely Oncogenic Loss-of-function 25807284 +ETV6 Fusions Likely Oncogenic Likely Gain-of-function 12173038, 10702799, 22578774 +TSC1 Truncating Mutations Likely Oncogenic Likely Loss-of-function 23485365, 24529379, 20301399 +TSC1 F216A Likely Oncogenic Likely Loss-of-function 18397877 +TSC1 H68R Likely Oncogenic Likely Loss-of-function 18397877 +TSC1 L180P Likely Oncogenic Loss-of-function 18830229 +TSC1 R1097H Likely Neutral Neutral 18830229 +TSC1 V128del Likely Oncogenic Loss-of-function 18830229 +TSC1 L191H Likely Oncogenic Loss-of-function 18830229 +TSC1 G305W Likely Neutral Neutral 18830229 +TSC1 M224R Oncogenic Loss-of-function 18830229 +TSC1 H105R Likely Oncogenic Loss-of-function 18397877 +TSC1 N198_F199delinsI Likely Oncogenic Loss-of-function 18830229, 11781698, 17304050 +TSC1 R509Q Likely Neutral Neutral 18830229 +TSC1 T417I Likely Neutral Neutral 18397877, 10570911, 10607950 +TSC1 V220F Likely Oncogenic Likely Loss-of-function 22923433 +TSC1 H206D Likely Oncogenic Loss-of-function 18397877 +TSC1 S35Q Likely Oncogenic Loss-of-function 18397877 +TSC1 F158C Likely Oncogenic Loss-of-function 18397877 +TSC1 R246K Likely Neutral Neutral 18830229 +TSC1 Deletion Likely Oncogenic Likely Loss-of-function 23485365, 24529379, 11741833, 10353610 +TSC1 K82T Likely Neutral Likely Neutral 23857276, 21309039 +TSC1 L117P Likely Oncogenic Loss-of-function 18830229 +TSC1 G305R Likely Neutral Neutral 18830229 +TSC1 G1035S Likely Neutral Neutral 18830229 +IKZF1 Deletion Likely Oncogenic Loss-of-function 27067989, 19129520, 27815723, 26202931 +TSC2 Truncating Mutations Likely Oncogenic Likely Loss-of-function 24529379, 14729330, 25724664, 14561707 +TSC2 V241del Oncogenic Loss-of-function 22903760 +TSC2 R505Q Likely Oncogenic Likely Loss-of-function 22903760 +TSC2 L493V Likely Oncogenic Likely Loss-of-function 22903760 +TSC2 E1552del Oncogenic Loss-of-function 22903760 +TSC2 V1673D Likely Oncogenic Likely Loss-of-function 22903760 +TSC2 F615S Likely Oncogenic Likely Loss-of-function 15483652, 11741832 +TSC2 G1596V Likely Oncogenic Likely Loss-of-function 22903760 +TSC2 V705M Likely Oncogenic Loss-of-function 22903760 +TSC2 R905G Likely Oncogenic Loss-of-function 17120248 +TSC2 Y598C Likely Oncogenic Likely Loss-of-function 22903760 +TSC2 L410R Oncogenic Loss-of-function 22903760 +TSC2 A889P Oncogenic Loss-of-function 22903760 +TSC2 H1620R Oncogenic Loss-of-function 22903760 +TSC2 L493P Likely Oncogenic Gain-of-function 22903760 +TSC2 S1498N Likely Oncogenic Likely Loss-of-function 15972957 +TSC2 L448P Likely Oncogenic Likely Loss-of-function 22903760 +TSC2 V299G Likely Oncogenic Likely Loss-of-function 22903760 +TSC2 T1623I Oncogenic Loss-of-function 22903760 +TSC2 V1673F Likely Oncogenic Likely Loss-of-function 22903760 +TSC2 H597Y Oncogenic Loss-of-function 22903760 +TSC2 R462C Likely Oncogenic Likely Loss-of-function 22903760 +TSC2 L1584R Likely Oncogenic Likely Loss-of-function 22903760 +TSC2 R905Q Likely Oncogenic Loss-of-function 17120248 +TSC2 E75G Likely Oncogenic Likely Loss-of-function 22903760, 27493206 +TSC2 A328P Likely Oncogenic Likely Loss-of-function 22903760 +TSC2 Deletion Oncogenic Likely Loss-of-function 11281455, 25724664, 26540169, 25281918, 14561707 +TSC2 C696Y Likely Oncogenic Loss-of-function 15483652, 11741832 +TSC2 Q1554H Likely Oncogenic Likely Loss-of-function 22903760 +TSC2 T1203K Oncogenic Loss-of-function 22903760 +TSC2 S1653P Oncogenic Loss-of-function 22903760 +TSC2 W1610G Likely Oncogenic Likely Loss-of-function 22903760 +TSC2 V769E Likely Oncogenic Loss-of-function 15483652, 11741832 +TSC2 S1653F Oncogenic Loss-of-function 22903760 +TSC2 V705E Oncogenic Loss-of-function 22903760 +TSC2 R1200W Likely Oncogenic Loss-of-function 21332470 +TSC2 L830R Oncogenic Loss-of-function 22903760 +TSC2 L826P Likely Oncogenic Likely Loss-of-function 15483652, 22903760 +TSC2 G1567D Likely Oncogenic Likely Loss-of-function 22903760 +TSC2 Y1571N Oncogenic Loss-of-function 22903760 +TSC2 L792R Oncogenic Loss-of-function 22903760 +TSC2 P1675L Likely Oncogenic Loss-of-function 11290735, 22903760, 12205112 +TSC2 R905W Likely Oncogenic Loss-of-function 17120248 +TSC2 S1036P Likely Oncogenic Likely Loss-of-function 21332470 +TSC2 P1709L Likely Oncogenic Likely Loss-of-function 22903760 +TSC2 L146R Likely Oncogenic Likely Loss-of-function 22903760 +TSC2 I427M Likely Oncogenic Likely Loss-of-function 22903760 +TSC2 R611Q Likely Oncogenic Loss-of-function 15483652, 11741832 +TSC2 A614D Likely Oncogenic Loss-of-function 15483652, 11741832 +TSC2 R611W Likely Oncogenic Loss-of-function 15483652, 11741832 +TSC2 Q1503P Likely Oncogenic Likely Loss-of-function 22903760 +TSC2 L844R Likely Oncogenic Likely Loss-of-function 22903760 +EWSR1 EWSR1-ATF1 Fusion Likely Oncogenic Likely Gain-of-function 24320889, 21822206, 25364450, 19801966 +EWSR1 EWSR1-CREB1 Fusion Likely Oncogenic Likely Gain-of-function 24320889, 21822206, 25364450, 19801966 +EWSR1 EWSR1-WT1 Fusion Oncogenic Gain-of-function 9591781, 11278460, 10999739, 11237525, 24321497 +EWSR1 EWSR1-ETV4 Fusion Likely Oncogenic Likely Gain-of-function 8605035 +EWSR1 EWSR1-ETV1 Fusion Oncogenic Gain-of-function 25109552 +EWSR1 EWSR1-FEV Fusion Likely Oncogenic Likely Gain-of-function 9121764 +EWSR1 EWSR1-DDIT3 Fusion Oncogenic Gain-of-function 24320889, 7805034, 24790523 +EWSR1 EWSR1-ERG Fusion Oncogenic Gain-of-function 18500345, 8162068, 10749119 +EWSR1 EWSR1-YY1 Fusion Oncogenic Gain-of-function 23630070 +EWSR1 EWSR1-NR4A3 Fusion Oncogenic Gain-of-function 22592656, 16604165 +EWSR1 Fusions Likely Oncogenic Likely Gain-of-function 8605035, 23329308, 21113140, 8834175 NCCN Bone Cancer. Volume# v.2017 https://www.nccn.org/professionals/physician_gls/pdf/bone.pdf +EWSR1 EWSR1-FLI1 Fusion Oncogenic Gain-of-function 17250957, 22930730, 24320889, 11715049, 25453903, 12432241 +ACVR1 R206H Likely Oncogenic Gain-of-function 24705254, 20463014, 22977237, 24769718 +ACVR1 G328E Likely Oncogenic Likely Gain-of-function 24705254, 20463014, 22977237, 24769718 +ACVR1 G328V Likely Oncogenic Gain-of-function 24705254, 20463014, 24705250, 24769718 +ACVR1 Q207E Likely Oncogenic Likely Gain-of-function 24852373 +FOXA1 L455M Likely Oncogenic Likely Loss-of-function 22722839 +FOXA1 Amplification Oncogenic Gain-of-function 22138582, 19470727, 22722839, 21147910, 22960745, 23622249, 19372580, 2298097, 23539448, 25079552, 12234996 +FOXA1 M253K Likely Oncogenic Likely Loss-of-function 23539448 +FOXA1 F400I Likely Oncogenic Likely Loss-of-function 22722839, 23539448 +FOXA1 G87R Likely Oncogenic Likely Loss-of-function 22722839 +FOXA1 S453fs* Likely Oncogenic Likely Gain-of-function 22722839 +FOXA1 L388M Likely Oncogenic Likely Loss-of-function 22722839 +FOXA1 Deletion Likely Oncogenic Likely Loss-of-function 24840332 +MDM2 Amplification Oncogenic Gain-of-function 9671804, 24667108, 15199139, 27194168 +ARID1A Truncating Mutations Likely Oncogenic Likely Loss-of-function 21900401, 24899687, 25625625 +ARID1A Deletion Likely Oncogenic Loss-of-function 22249247, 23097632, 21412130, 23208470 +EZH2 Amplification Oncogenic Gain-of-function 16330673, 12374981, 14500907, 21837672 +EZH2 A677G Likely Oncogenic Switch-of-function 22323599 +EZH2 Y646C Oncogenic Switch-of-function 21078963, 21190999 +EZH2 Y646N Oncogenic Switch-of-function 21078963, 21190999, 24469040, 21810159, 21843048 +EZH2 Y646F Oncogenic Switch-of-function 21078963, 21190999, 27135738, 24469040, 21810159, 21843048 +EZH2 Overexpression Oncogenic Gain-of-function 16330673, 12374981, 14500907, 21837672 +EZH2 Y646H Oncogenic Switch-of-function 21078963, 21190999 +EZH2 Y646S Oncogenic Switch-of-function 21078963, 21190999 +MDM4 G57A Oncogenic Loss-of-function 15199139, 9131587 +MDM4 Amplification Oncogenic Gain-of-function 9523192, 15199139, 7585611 +KLF4 K409Q Likely Oncogenic Likely Gain-of-function 23404370 +RXRA S247Y Inconclusive Inconclusive 24476821 +RXRA S247F Inconclusive Inconclusive 24476821 +MAP3K1 Truncating Mutations Likely Oncogenic Inconclusive 24003131, 24386504 +MAP3K1 E1286V Likely Neutral Likely Neutral 25899310 +MAP3K1 T779fs Likely Oncogenic Likely Loss-of-function 25899310 +MAP3K1 T1481fs Likely Oncogenic Likely Loss-of-function 25899310 +AXIN1 Truncating Mutations Likely Oncogenic Likely Loss-of-function 10700176, 25236910 +AXIN2 Truncating Mutations Likely Oncogenic Likely Loss-of-function 15802015, 17373666 +BAP1 Deletion Likely Oncogenic Likely Loss-of-function 21874000, 26246155, 24633195, 25970771 +BAP1 F81V Likely Oncogenic Loss-of-function 26680512 +BAP1 I47F Likely Oncogenic Loss-of-function 26680512 +BAP1 Truncating Mutations Likely Oncogenic Likely Loss-of-function 21874000, 18757409 +BAP1 E685V Likely Oncogenic Loss-of-function 25830670 +BAP1 C91S Oncogenic Loss-of-function 19815555, 9528852 +BAP1 C91A Likely Oncogenic Loss-of-function 18757409 +BAP1 F170I Likely Oncogenic Loss-of-function 26081045 +BAP1 A95D Likely Oncogenic Loss-of-function 26680512, 24894717, 18757409 +BAP1 G178V Likely Oncogenic Loss-of-function 24894717, 18757409 +MEN1 Truncating Mutations Likely Oncogenic Likely Loss-of-function +MEN1 Deletion Oncogenic Loss-of-function 12746426, 27076911, 9510467, 16740708, 21627674, 14633735, 12941803 +FANCA Deletion Likely Oncogenic Likely Loss-of-function 15522956, 12637330, 24689079, 8374893, 12827451, 14749703 +FANCA L274P Likely Oncogenic Loss-of-function 16720839 +FANCA S858R Likely Oncogenic Loss-of-function 12955722 +FANCA R1055L Likely Oncogenic Likely Loss-of-function 16720839 +FANCA L210R Likely Oncogenic Loss-of-function 16720839 +FANCA Truncating Mutations Likely Oncogenic Likely Loss-of-function 21273304, 15522956, 24689079, 12827451 +FANCA H492R Likely Oncogenic Loss-of-function 16720839, 12444097 +FANCA S1088F Likely Oncogenic Likely Loss-of-function Wilkes et al. Molecular Case Studies, 2016 http://molecularcasestudies.cshlp.org/content/early/2017/05/03/mcs.a001487.short +FANCA Y510C Likely Oncogenic Loss-of-function 16720839 +FANCA W183A Likely Oncogenic Loss-of-function 10468606, 11050007, 11161829 +FANCC Truncating Mutations Likely Oncogenic Likely Loss-of-function 11520787, 16687415, 20509860 +MET Y1230C Likely Oncogenic Gain-of-function 9826708, 18709663 +MET H1094R Oncogenic Gain-of-function 9563489 +MET D1010H Likely Oncogenic Likely Gain-of-function 27666659, 14559814, 16227611, 25898965, 25971938, 15735036, 27343443, 16397241, 26892698, 19096300 +MET X1009_splice Oncogenic Gain-of-function 15735036, 16397241, 19096300 +MET H1094Y Oncogenic Gain-of-function 15064724, 24061647 +MET E168D Likely Oncogenic Gain-of-function 19318576 Ma et al. Abstract# 14010 ASCO 2010 http://hwmaint.meeting.ascopubs.org/cgi/content/abstract/25/18_suppl/14010 +MET X1006_splice Oncogenic Gain-of-function 15735036, 16397241, 19096300 +MET L1195V Oncogenic Gain-of-function 15064724, 24061647 +MET T992I Likely Oncogenic Gain-of-function 25605252, 14559814, 21970370, 11042681, 22973954, 15735036, 17322284 +MET N1100Y Oncogenic Gain-of-function 12460923 +MET V1220I Likely Oncogenic Gain-of-function 19783361 +MET Y1003F Oncogenic Gain-of-function 16227611, 15123609, 11741535 +MET H1106D Likely Oncogenic Likely Gain-of-function 10327054 +MET X1008_splice Oncogenic Gain-of-function 15735036, 16397241, 19096300 +MET M1250T Oncogenic Gain-of-function 10327054, 10871851, 9826715, 15557554 +MET Y1003C Likely Oncogenic Likely Gain-of-function 16227611, 15123609, 11741535 +MET Y1230H Oncogenic Gain-of-function 27666659, 9826708, 9326629 +MET V1188L Oncogenic Gain-of-function 15064724, 24061647 +MET PTPRZ1-MET Fusion Likely Oncogenic Likely Gain-of-function 25135958 +MET F1200I Oncogenic Gain-of-function 24173966, 21697284 +MET Amplification Oncogenic Gain-of-function 16461907, 20129249, 19117057, 17667909, 22869872, 18077425, 17463250 +MET D1010Y Likely Oncogenic Likely Gain-of-function 27666659, 14559814, 16227611, 25898965, 25971938, 15735036, 27343443, 16397241, 19096300 +MET X963_splice Oncogenic Gain-of-function 15735036, 16397241, 19096300 +MET R970C Inconclusive Inconclusive 20670955, 14559814, 22973954 +MET Y1235D Oncogenic Gain-of-function 12460923, 10734314 +MET H1094L Oncogenic Gain-of-function 19783361, 24061647 +MET 963_D1010splice Oncogenic Gain-of-function 15735036, 16397241, 19096300 +MET D1010N Likely Oncogenic Likely Gain-of-function 26892698 +MET Overexpression Oncogenic Gain-of-function 9554529, 9870683, 8077049, 11381087, 15375530, 10698493 +MET V1070E Oncogenic Gain-of-function 25401301 +MET V1092I Oncogenic Gain-of-function 24061647, 10417759 +MET X1007_splice Oncogenic Gain-of-function 15735036, 16397241, 19096300 +MET D1228N Likely Oncogenic Likely Gain-of-function 9826708, 27343442 +MET N375S Inconclusive Inconclusive 16171945, 19723643 +MET Y1003* Likely Oncogenic Likely Gain-of-function 25079552, 16397241 +MET 981_1028splice Oncogenic Gain-of-function 15735036, 16397241, 19096300 +U2AF1 Q157R Oncogenic Switch-of-function 25267526, 25311244 +U2AF1 Q157P Likely Oncogenic Switch-of-function 25267526, 25311244 +U2AF1 S34Y Oncogenic Switch-of-function 22158538, 25267526, 25311244 +U2AF1 S34F Likely Oncogenic Switch-of-function 25965570, 22158538, 25267526, 25311244 +KMT2C Deletion Likely Oncogenic Likely Loss-of-function 23166019, 11891048, 24081332, 24794707, 9834205 +KMT2C Truncating Mutations Likely Oncogenic Likely Loss-of-function 23259788, 19433796, 25537518 +KMT2C A1685S Likely Oncogenic Loss-of-function 25998713, 25151357 +KMT2C S3660L Likely Neutral Likely Neutral 24965397 +PARP1 Truncating Mutations Likely Oncogenic Likely Loss-of-function +FAT1 P4309A Likely Oncogenic Likely Loss-of-function 23354438 +FAT1 A4419S Likely Oncogenic Likely Loss-of-function 23354438 +FAT1 T4511I Likely Oncogenic Likely Loss-of-function 23354438 +FAT1 Truncating Mutations Likely Oncogenic Likely Loss-of-function 24718888, 26905694, 23354438 +FAT1 Deletion Oncogenic Loss-of-function 21617878, 23354438 +ARID1B Truncating Mutations Likely Oncogenic Likely Loss-of-function 23660946, 22233809, 26340334 +ARID1B Deletion Likely Oncogenic Likely Loss-of-function 23202128, 25674384, 26340334 +PIK3CA E453K Oncogenic Gain-of-function 20593314, 21266528, 26627007 +PIK3CA N345K Oncogenic Gain-of-function 18074223, 20593314, 22949682, 17376864 +PIK3CA N1044K Oncogenic Gain-of-function 26627007 +PIK3CA M1043I Oncogenic Gain-of-function 22120714, 17376864 +PIK3CA G118D Likely Oncogenic Gain-of-function 22949682 +PIK3CA E81K Likely Oncogenic Likely Gain-of-function 25915946, 21266528 +PIK3CA M1043V Oncogenic Gain-of-function 17376864 +PIK3CA E542G Inconclusive Inconclusive 17990317, 25054828, 22553375, 25401499 +PIK3CA E545Q Oncogenic Gain-of-function 20593314, 26627007 +PIK3CA E453A Likely Oncogenic Likely Gain-of-function 20593314, 21266528 +PIK3CA I31M Likely Neutral Likely Neutral 26627007 +PIK3CA E110K Likely Oncogenic Likely Gain-of-function 23619167 +PIK3CA C420R Oncogenic Gain-of-function 18074223, 21266528, 22949682 +PIK3CA Q546P Oncogenic Gain-of-function 17626883, 17376864 +PIK3CA R38H Oncogenic Gain-of-function 15930273, 20593314, 17376864 +PIK3CA H1047L Oncogenic Gain-of-function 20593314, 26627007, 22120714, 17376864 +PIK3CA A1020V Likely Neutral Likely Neutral 26627007 +PIK3CA E545A Oncogenic Gain-of-function 20593314, 26627007, 17376864 +PIK3CA Q546K Oncogenic Gain-of-function 27126994, 17376864 +PIK3CA E545G Oncogenic Gain-of-function 20593314, 26627007, 17376864 +PIK3CA T1025S Oncogenic Gain-of-function 17376864 +PIK3CA P447_L455del Likely Oncogenic Likely Gain-of-function 27126994 +PIK3CA K111N Likely Oncogenic Likely Gain-of-function 18074223, 21266528, 26627007, 22949682, 17376864 +PIK3CA Q60K Likely Neutral Likely Neutral 18074223 +PIK3CA H701P Likely Neutral Likely Neutral 18074223, 17376864 +PIK3CA G106R Likely Oncogenic Gain-of-function 21266528 +PIK3CA E542K Oncogenic Gain-of-function 20593314, 16432179, 26627007, 17376864 +PIK3CA E365K Likely Oncogenic Gain-of-function 21266528 +PIK3CA C378R Likely Oncogenic Likely Gain-of-function 17363507 +PIK3CA V344G Inconclusive Inconclusive 27007084, 17050665, 24718026 +PIK3CA E542V Oncogenic Gain-of-function 26627007 +PIK3CA E453Q Likely Oncogenic Likely Gain-of-function 15930273, 20593314 +PIK3CA I391M Likely Neutral Likely Neutral 20530683 +PIK3CA Q546E Oncogenic Gain-of-function 26627007 +PIK3CA D350G Likely Oncogenic Gain-of-function 24265155 +PIK3CA V344A Likely Oncogenic Likely Gain-of-function 20593314, 21266528 +PIK3CA H1047Y Oncogenic Gain-of-function 20593314, 26627007, 17376864 +PIK3CA E116K Likely Neutral Likely Neutral 17376864 +PIK3CA H1047R Oncogenic Gain-of-function 16322248, 19029981, 22960745, 16341083, 22214849, 16432179, 26627007, 21822287, 27126994, 25079552, 22120714, 21324922, 23940356, 25631445, 20593314, 22941189, 22370636, 23787421, 23636398, 17376864 +PIK3CA P449_L455del Likely Oncogenic Gain-of-function 20593314, 21266528, 27126994 +PIK3CA D1029Y Likely Oncogenic Likely Gain-of-function 19394761 +PIK3CA R108H Likely Oncogenic Gain-of-function 18829572 +PIK3CA P539R Oncogenic Gain-of-function 17376864 +PIK3CA R93Q Likely Oncogenic Likely Gain-of-function 21266528 +PIK3CA E545K Oncogenic Gain-of-function 16322248, 20593314, 16432179, 26627007, 17376864 +PIK3CA G106_R108del Likely Oncogenic Likely Gain-of-function 19394761 +PIK3CA R93W Likely Oncogenic Gain-of-function 20593314, 21266528, 22949682 +PIK3CA R115L Likely Neutral Likely Neutral 23619167 +PIK3CA G106V Likely Oncogenic Gain-of-function 15930273, 21266528 +PIK3CA P449T Oncogenic Gain-of-function 20530683 +PIK3CA K111E Oncogenic Gain-of-function 18074223, 21266528, 22949682 +PIK3CA N345I Likely Oncogenic Likely Gain-of-function 20593314, 26627007 +PIK3CA G106D Likely Oncogenic Likely Gain-of-function 27555788, 15930273, 21266528 +PIK3CA A1066V Likely Neutral Likely Neutral 27465249, 22430209 +PIK3CA E78K Inconclusive Inconclusive 27126994 +PIK3CA Q546R Oncogenic Gain-of-function 17626883, 26627007 +PIK3CA G914R Likely Oncogenic Likely Gain-of-function 22228622, 22729224 +PIK3CA Amplification Likely Oncogenic Likely Gain-of-function 21720365, 22960745, 17992665, 23136191, 19706770, 22292935, 22994622, 19697359, 25631445, 24608574, 26876212, 23636398, 27095573, 17803655 Zehir A et al. Nature Medicine, 2017 http://doi:10.1038/nm.4333 +PIK3CA N1068fs*4 Likely Oncogenic Gain-of-function 21703185 +PIK3CA E542Q Likely Oncogenic Likely Gain-of-function 16432179, 26627007, 17376864 +PIK3CA E579K Likely Oncogenic Likely Gain-of-function 17376864 +PIK3CA R88Q Likely Oncogenic Gain-of-function 22949682 +PIK3CB R48W Likely Oncogenic Likely Gain-of-function 18755892, 26000489 +PIK3CB D1067V Oncogenic Gain-of-function 25982275 +PIK3CB E1051K Likely Oncogenic Likely Gain-of-function 18755892, 26000489 +PIK3CB E552K Likely Oncogenic Gain-of-function 16339315 +PIK3CB E633K Likely Oncogenic Likely Gain-of-function 23734178, 20668451 +PIK3CB D1067A Likely Oncogenic Gain-of-function 26759240 +PIK3CB ACPP-PIK3CB Fusion Likely Oncogenic Likely Gain-of-function 26000489, 16432180 +PIK3CB N553S Likely Oncogenic Likely Gain-of-function 18755892, 26000489 +PIK3CB D1067Y Oncogenic Gain-of-function 26759240 +PIK3CB Fusions Likely Oncogenic Likely Gain-of-function 26000489, 16432180 +PIK3CB Amplification Oncogenic Gain-of-function 24418330, 26442967, 16432180, 25533673 +PIM1 E142D Inconclusive Inconclusive 23755147 +PIM1 P123M Likely Neutral Likely Neutral 15808862 +PIM1 L193F Likely Oncogenic Likely Loss-of-function 15808862 +PIM1 N82K Likely Neutral Likely Loss-of-function 15808862 +PIM1 P81S Likely Oncogenic Likely Loss-of-function 15808862 +PIM1 Y53H Inconclusive Inconclusive 23755147 +PIM1 E124Q Inconclusive Inconclusive 23755147 +PIM1 H68Y Likely Oncogenic Likely Gain-of-function 15808862 +PIM1 E135K Inconclusive Inconclusive 23755147, 15808862, 19734423 +PIK3CD E525K Likely Oncogenic Gain-of-function 24136356, 24165795 +PIK3CD E1021K Likely Oncogenic Gain-of-function 24136356, 24165795 +PIK3CD N334K Likely Oncogenic Gain-of-function 24165795 +YAP1 Fusions Likely Oncogenic Likely Gain-of-function 23737213, 25965568, 24553141 +YAP1 Amplification Oncogenic Gain-of-function 16140918, 15586366, 16814713, 24336504, 19952108, 15824737, 8569172, 10092132, 17114655, 20842732, 23502453, 24511017, 12651874, 12208731, 19551889 +YAP1 YAP1-MAMLD1 Fusion Likely Oncogenic Likely Gain-of-function 25965575 +YAP1 YAP1-FAM118B Fusion Likely Oncogenic Likely Gain-of-function 25965575 +YAP1 YAP1-TFE3 Fusion Likely Oncogenic Likely Gain-of-function 23737213 +PIK3R1 E137K Likely Oncogenic Likely Loss-of-function 24367658 +PIK3R1 R574fs Oncogenic Loss-of-function 20713702 +PIK3R1 R348* Oncogenic Loss-of-function 21478295, 25284480, 21984976 +PIK3R1 Deletion Likely Oncogenic Likely Loss-of-function 24229379, 25488983, 25133428 +PIK3R1 W237_Y242del Likely Oncogenic Likely Loss-of-function 24367658 +PIK3R1 T576del Oncogenic Loss-of-function 20713702 +PIK3R1 Q579_L581del Oncogenic Loss-of-function 19962665 +PIK3R1 K379E Oncogenic Loss-of-function 20713702 +PIK3R1 E439del Likely Oncogenic Loss-of-function 20713702 +PIK3R1 R262T Likely Oncogenic Likely Loss-of-function 24367658 +PIK3R1 X434_splice Likely Oncogenic Loss-of-function 25488983, 25133428 +PIK3R1 N564D Oncogenic Loss-of-function 24367658 +PIK3R1 D560Y Likely Oncogenic Loss-of-function 20713702 +PIK3R1 R503W Oncogenic Loss-of-function 25957691, 21984976 +PIK3R1 G376R Likely Oncogenic Loss-of-function 20713702 +PIK3R1 X475_splice Likely Oncogenic Loss-of-function 25488983, 25133428 +PIK3R1 E218* Likely Oncogenic Likely Loss-of-function 24367658 +PIK3R1 K459_S460delinsN Oncogenic Loss-of-function 20713702 +PIK3R1 R162* Likely Oncogenic Likely Loss-of-function 24367658 +PIK3R1 E160* Oncogenic Loss-of-function 25284480, 21984976 +PIK3R1 Truncating Mutations Likely Oncogenic Likely Loss-of-function 25488983, 25284480, 25133428 +PIK3R1 X582_splice Likely Oncogenic Likely Loss-of-function 25488983, 25284480, 25133428 +PIK3R1 N564K Likely Oncogenic Loss-of-function 20713702 +PIK3R1 K288Q Likely Oncogenic Likely Loss-of-function 24367658 +PIK3R1 L370fs Likely Oncogenic Likely Loss-of-function 25284480 +PIK3R1 I559_D560insDKRMNS Oncogenic Loss-of-function 20713702 +PIK3R2 A36E Likely Neutral Likely Neutral 21984976 +PIK3R2 A171V Oncogenic Gain-of-function 21984976 +PIK3R2 K376N Inconclusive Inconclusive 21984976 +PIK3R2 N561D Oncogenic Gain-of-function 21984976 +PIK3R2 G373R Likely Oncogenic Gain-of-function 26520804, 22729224 +PIK3R2 Amplification Likely Oncogenic Likely Gain-of-function 25502460 +PIK3R2 A727V Likely Neutral Likely Neutral 21984976 +PIK3R2 D557H Likely Oncogenic Likely Loss-of-function 26860062, 26520804 +PIK3R2 S273C Likely Neutral Likely Neutral 21984976 +ARID5B Truncating Mutations Likely Oncogenic Likely Loss-of-function Kawamata and Itakura Abstract# LB-150, AACR 2016 http://cancerres.aacrjournals.org/content/76/14_Supplement/LB-150 +HRAS T58I Likely Oncogenic Likely Gain-of-function 26888048 +HRAS A146T Oncogenic Gain-of-function 17054105, 19075190, 20570890, 20147967, 2403644 +HRAS G13V Likely Oncogenic Likely Gain-of-function 9219684, 21993244, 22589270, 18713003 +HRAS K117N Likely Oncogenic Likely Gain-of-function 20570890 +HRAS G13D Likely Oncogenic Likely Gain-of-function 26561417, 9219684, 26037647, 21993244, 22722830, 20147967 +HRAS F28L Likely Oncogenic Gain-of-function 25600866 +HRAS Q61K Oncogenic Gain-of-function 10574788, 18073111, 9219684, 21993244, 20194776 +HRAS A59G Likely Oncogenic Gain-of-function 17084704, 20838576 +HRAS Q22K Likely Oncogenic Likely Gain-of-function 17412879 +HRAS G12A Likely Oncogenic Likely Gain-of-function 9219684, 21993244, 25013473 +HRAS G12D Oncogenic Gain-of-function 9219684, 21993244, 24123531 +HRAS A59T Likely Oncogenic Likely Gain-of-function 1730690 +HRAS G12S Oncogenic Gain-of-function 9219684, 21993244, 20979192, 25284075, 24129065 +HRAS G12V Oncogenic Gain-of-function 9219684, 21993244, 24240680, 22589270 +HRAS Q61H Likely Oncogenic Likely Gain-of-function 10574788, 25705018, 9219684, 21993244, 20194776, 20147967 +HRAS Q61R Likely Oncogenic Likely Gain-of-function 10574788, 9219684, 21993244, 20194776, 25437878 +HRAS A146V Likely Oncogenic Likely Gain-of-function 18247425 +HRAS Q61L Oncogenic Gain-of-function 22256804, 10574788, 9219684, 21993244, 20194776 +HRAS Amplification Likely Oncogenic Likely Gain-of-function 8221670, 3283542, 1855225 +HRAS G13R Likely Oncogenic Likely Gain-of-function 9219684, 21993244 +HRAS G12C Likely Oncogenic Likely Gain-of-function 25705018, 9219684, 21993244, 24256730, 16051643, 26841430 +HRAS P34R Likely Oncogenic Likely Gain-of-function 16474404, 8246952 +HRAS Y64A Likely Oncogenic Likely Gain-of-function 24516166 +HRAS K117R Oncogenic Gain-of-function 17054105, 16443854, 20570890, 24247240, 20147967 +HRAS G13C Likely Oncogenic Likely Gain-of-function 25705018, 9219684, 21993244, 17211612, 21079152 +MLH1 M587V Inconclusive Inconclusive 18206535 +MLH1 R487* Likely Oncogenic Likely Loss-of-function 24362816, 16216036, 15713769 +MLH1 P648S Inconclusive Inconclusive 23435383, 24362816 +MLH1 G67R Likely Oncogenic Likely Loss-of-function 21120944 +MLH1 V716M Likely Neutral Likely Neutral 24362816, 21120944 +MLH1 L749P Inconclusive Inconclusive 23435383, 24362816 +MLH1 L550P Likely Oncogenic Likely Loss-of-function 23435383, 24362816 +MLH1 L622H Inconclusive Inconclusive 23435383, 24362816 +MLH1 L559R Inconclusive Inconclusive 23435383, 24362816 +MLH1 T117M Likely Oncogenic Loss-of-function 24362816, 8566964, 12919140, 11781295 +MLH1 R659P Inconclusive Inconclusive 23435383 +MLH1 K618T Likely Neutral Likely Neutral 24362816, 19863800 +MLH1 K618A Likely Oncogenic Likely Loss-of-function 22426235, 24362816, 18205192 +MLH1 R659L Likely Oncogenic Likely Loss-of-function 23435383 +MLH1 V384D Likely Neutral Likely Neutral 12037578, 24362816 +MLH1 Q689R Likely Neutral Likely Neutral 24362816, 25092538 +MLH1 A120S Oncogenic Loss-of-function 24755471 +MLH1 R659* Oncogenic Loss-of-function 23435383 +MLH1 I219V Likely Neutral Likely Neutral 24362816, 11781295 +MLH1 P648L Likely Oncogenic Loss-of-function 23435383, 24362816 +MLH1 V506A Inconclusive Inconclusive 23435383, 24362816 +MLH1 R265C Oncogenic Loss-of-function 19419416, 18205192, 11781295 +MLH1 N551T Likely Oncogenic Likely Loss-of-function 23435383, 24362816 +MLH1 R217C Likely Neutral Likely Neutral 12810663, 17510385, 11781295 +MLH1 A111P Likely Oncogenic Likely Loss-of-function 20020535 +MLH1 G67W Likely Oncogenic Loss-of-function 16528606, 24362816, 17510385, 9927034 +MLH1 D737V Inconclusive Inconclusive 23435383, 24362816 +MLH1 E172K Inconclusive Inconclusive 24755471, 20668451 +MLH1 P654L Inconclusive Inconclusive 23435383 +MLH1 Truncating Mutations Likely Oncogenic Likely Loss-of-function 12697830, 7892206, 11781295 +MLH1 T82A Likely Oncogenic Loss-of-function 24362816, 22736432 +MLH1 R265S Likely Oncogenic Likely Loss-of-function 20020535, 17210669, 24362816 +MLH1 W714* Likely Oncogenic Loss-of-function 23435383, 24362816 +MLH1 R725C Inconclusive Inconclusive 24362816, 23403630 +MLH1 G101S Likely Oncogenic Likely Loss-of-function 22290698, 24362816, 24278394 +MLH1 L582F Inconclusive Inconclusive 23435383, 24362816 +MLH1 R100* Likely Oncogenic Loss-of-function 15872200, 14512394 +MLH1 R226* Likely Oncogenic Likely Loss-of-function 11343035, 24362816, 9927033 +MLH1 R755S Likely Oncogenic Likely Loss-of-function 23435383, 24362816 +FGF3 Amplification Inconclusive Inconclusive 24265351, 22890726, 10845805, 9205106 +FGF4 Amplification Inconclusive Inconclusive 24265351, 22890726 +KMT2A Truncating Mutations Likely Oncogenic Likely Loss-of-function 25998713 +KMT2A Fusions Likely Oncogenic Likely Gain-of-function 25998713, 23628958, 8681380, 11265751, 18455126 +KMT2A Amplification Inconclusive Inconclusive 17908926, 15378024 +AKT1 Q79E Oncogenic Gain-of-function 23134728 +AKT1 D32Y Likely Neutral Likely Neutral 23134728, 23237847, 19706770 +AKT1 Amplification Likely Oncogenic Gain-of-function 14655756, 12631397, 1409633, 24896186, 17616691, 3037531, 11485901 +AKT1 R23A Oncogenic Gain-of-function 23134728 +AKT1 W80A Likely Oncogenic Gain-of-function 25856301, 18669636, 25551293 +AKT1 G311D Likely Oncogenic Likely Switch-of-function 25551293, 22460905 +AKT1 V270A Oncogenic Gain-of-function 23134728 +AKT1 E17K Oncogenic Gain-of-function 23134728, 20440266, 23741320, 18256540, 21793738, 17611497, 9843996 +AKT1 K39N Likely Neutral Likely Neutral 23134728, 23237847, 19706770 +AKT1 L362R Likely Neutral Neutral 23134728 +AKT1 E191A Oncogenic Gain-of-function 23134728 +AKT1 L321A Oncogenic Gain-of-function 23134728 +AKT1 L52R Oncogenic Gain-of-function 23134728, 27147599, 20886116 +AKT1 T195I Oncogenic Gain-of-function 23134728 +AKT1 D325A Oncogenic Gain-of-function 23134728 +AKT1 E267G Likely Oncogenic Likely Gain-of-function 27147599 +AKT1 L78T Oncogenic Gain-of-function 23134728 +AKT1 R200A Likely Neutral Neutral 23134728 +AKT1 K189N Oncogenic Gain-of-function 23134728 +AKT1 Q79K Likely Oncogenic Gain-of-function 23134728, 20886116, 24265152 +AKT1 K179M Likely Oncogenic Likely Switch-of-function 7774014, 25551293 +AKT1 C77F Likely Oncogenic Likely Gain-of-function 22722193, 23237847 +AKT1 V271A Oncogenic Gain-of-function 23134728 +AKT1 R370C Likely Oncogenic Likely Gain-of-function 27147599 +AKT1 R328A Oncogenic Gain-of-function 23134728 +AKT1 E49K Oncogenic Gain-of-function 19802009 +AKT1 P42T Likely Neutral Likely Neutral 23134728, 23237847, 19706770 +AKT1 L202F Likely Neutral Neutral 23134728 +AKT1 N53A Oncogenic Gain-of-function 23134728 +AKT1 Q59E Likely Neutral Neutral 23134728 +AKT1 E40K Oncogenic Gain-of-function 9690513, 9843996 +AKT1 D323H Likely Oncogenic Gain-of-function 23134728, 20886116 +AKT2 G161V Likely Oncogenic Switch-of-function 25551293 +AKT2 D399N Likely Oncogenic Gain-of-function 19738612 +AKT2 Amplification Oncogenic Gain-of-function 8622988 +AKT2 E17K Oncogenic Gain-of-function 19372382, 24285683, 21979934, 17611497 +AKT2 I289M Oncogenic Gain-of-function 25551293 +AKT2 R368C Likely Oncogenic Gain-of-function 19738612, 25551293 +AKT2 D32H Likely Oncogenic Gain-of-function 19738612 +AKT2 BCAM-AKT2 Fusion Likely Oncogenic Gain-of-function 25733895 +AKT2 K181M Likely Oncogenic Switch-of-function 25551293 +AKT2 H355M Oncogenic Gain-of-function 25551293 +AKT2 R170W Oncogenic Gain-of-function 25551293 +AKT2 Fusions Likely Oncogenic Likely Gain-of-function 25733895 +FGFR1 E664K Likely Neutral Likely Loss-of-function 19733072 +FGFR1 FGFR1-TACC1 Fusion Oncogenic Gain-of-function 22837387, 23558953 +FGFR1 N546K Oncogenic Gain-of-function 24777483, 24806303, 19224897, 24705251, 22820256, 16186508, 23817572, 24140581, 14602678 +FGFR1 Amplification Oncogenic Gain-of-function 24265351, 23658459, 22960745, 26451490, 15863030, 15863033, 21160078, 24476821, 25677745, 17121884 +FGFR1 ERLIN2?FGFR1 Fusion Likely Oncogenic Gain-of-function 23558953 +FGFR1 BCR-FGFR1 Fusion Likely Oncogenic Gain-of-function 11739186, 20226962 +FGFR1 ZNF198-FGFR1 Fusion Likely Oncogenic Gain-of-function 20226962, 10887137, 10935490 +FGFR1 K656E Likely Oncogenic Gain-of-function 15509736, 23817572 +FGFR1 A263V Likely Neutral Likely Neutral 26826182 +FGFR1 Fusions Likely Oncogenic Likely Gain-of-function 23558953 +FGFR1 FGFR1OP1-FGFR1 Fusion Likely Oncogenic Gain-of-function 11689702, 16690081, 21330321, 20226962 +FGFR1 V561M Likely Oncogenic Likely Gain-of-function 15157880, 25686244 +FGFR1 CEP110-FGFR1 Fusion Likely Oncogenic Gain-of-function 10688839, 20226962 +FGFR1 CUX1-FGFR1 Fusion Likely Oncogenic Gain-of-function 21330321 +FGFR3 FGFR3 - BAIAP2L1 Fusion Oncogenic Gain-of-function 23175443 +FGFR3 I538F Likely Neutral Likely Neutral 26992226 +FGFR3 K650T Likely Oncogenic Likely Gain-of-function 11055896, 19749790 +FGFR3 V555M Likely Oncogenic Gain-of-function 26992226 +FGFR3 P572A Likely Neutral Likely Neutral 26992226 +FGFR3 FGFR3-TACC3 Fusion Oncogenic Gain-of-function 25609060, 22837387 +FGFR3 G380R Likely Oncogenic Gain-of-function 12461689, 10646125, 10611230, 21324899 +FGFR3 I538V Likely Oncogenic Gain-of-function 26992226 +FGFR3 N653H Likely Neutral Likely Neutral 26992226 +FGFR3 G697C Likely Neutral Likely Neutral 26992226 +FGFR3 D646Y Likely Neutral Likely Neutral 26992226 +FGFR3 F384L Likely Neutral Likely Neutral 11157491 +FGFR3 A500T Likely Neutral Likely Neutral 26992226 +FGFR3 K650E Likely Oncogenic Gain-of-function 19749790, 11429702 +FGFR3 H643D Likely Neutral Likely Neutral 26992226 +FGFR3 Y647C Likely Oncogenic Likely Gain-of-function 26992226 +FGFR3 A391E Likely Oncogenic Gain-of-function 23437153 +FGFR3 R669G Likely Oncogenic Gain-of-function 26992226 +FGFR3 V677I Likely Neutral Likely Neutral 26992226 +FGFR3 Y373C Oncogenic Gain-of-function 19749790, 16338952, 11429702 +FGFR3 K650R Likely Oncogenic Likely Gain-of-function 11055896, 19749790 +FGFR3 Fusions Likely Oncogenic Likely Gain-of-function 23298836, 23661334, 23558953 +FGFR3 G370C Likely Oncogenic Gain-of-function 12009017 +FGFR3 D641G Likely Oncogenic Gain-of-function 26992226 +FGFR3 N540K Oncogenic Gain-of-function 26992226 +FGFR3 K650M Likely Oncogenic Likely Gain-of-function 11055896, 19749790, 10053006 +FGFR3 S371C Likely Oncogenic Gain-of-function 12009017 +FGFR3 E466K Likely Neutral Likely Neutral 26992226 +FGFR3 G375C Likely Oncogenic Gain-of-function 22529939 +FGFR3 S249C Oncogenic Gain-of-function 19749790, 16338952, 17384684 +FGFR3 K650Q Likely Oncogenic Likely Gain-of-function 11055896, 19749790 +FGFR3 Amplification Oncogenic Gain-of-function 17344846, 20094046, 19821490 +FGFR3 C582F Likely Neutral Likely Neutral 26992226 +FGFR3 IGH-FGFR3 Fusion Oncogenic Gain-of-function 17107900 +FGFR3 K650N Likely Oncogenic Likely Gain-of-function 11055896, 19749790 +FGFR3 R248C Oncogenic Gain-of-function 22203368, 8640234 +FGFR3 K508M Inconclusive Inconclusive 22837387 +FGFR3 G637W Likely Neutral Likely Loss-of-function 26992226 +FGFR3 E627D Likely Neutral Likely Neutral 26992226 +FGFR3 D641N Likely Oncogenic Gain-of-function 26992226 +FGFR3 D617G Likely Neutral Likely Loss-of-function 26992226 +FGFR3 N540S Likely Oncogenic Gain-of-function 26992226 +FGFR3 G382D Likely Oncogenic Likely Gain-of-function 11429702 +SPOP P94A Likely Oncogenic Loss-of-function 19818708, 18218622, 25766326 +SPOP M117I Likely Oncogenic Loss-of-function 19818708, 18218622, 25766326 +SPOP E47K Likely Oncogenic Loss-of-function 19818708, 18218622, 25766326 +SPOP W131A Likely Oncogenic Likely Loss-of-function 19818708, 18218622 +SPOP F133L Likely Oncogenic Loss-of-function 19818708, 18218622, 25274033, 24508459, 23559371 +SPOP S80R Likely Oncogenic Loss-of-function 19818708, 18218622, 25766326 +SPOP N296I Likely Oncogenic Likely Loss-of-function 19818708, 23559371, 24796539 +SPOP D130A Likely Oncogenic Likely Loss-of-function 19818708, 18218622, 22085717 +SPOP Y87N Likely Oncogenic Loss-of-function 19818708, 18218622, 25274033, 24508459, 23559371 +SPOP F102C Likely Oncogenic Loss-of-function 19818708, 18218622, 25274033, 24508459, 23559371 +SPOP E50K Likely Oncogenic Loss-of-function 19818708, 18218622, 25766326 +SPOP R121Q Likely Oncogenic Loss-of-function 19818708, 18218622, 25766326 +SPOP G75R Likely Oncogenic Loss-of-function 19818708, 18218622, 25766326 +SPOP Y87C Likely Oncogenic Loss-of-function 19818708, 18218622, 25274033, 24508459, 23559371 +SPOP D140G Likely Oncogenic Loss-of-function 19818708, 18218622, 25766326 +SPOP W131G Likely Oncogenic Loss-of-function 19818708, 18218622, 25274033, 24508459, 23559371 +SPOP M117V Likely Oncogenic Loss-of-function 19818708, 18218622, 25766326 +SPOP K134N Likely Oncogenic Likely Loss-of-function 19818708, 18218622, 24990631 +SPOP Truncating Mutations Likely Oncogenic Likely Loss-of-function 26344095 +SPOP F133V Likely Oncogenic Loss-of-function 19818708, 18218622, 25274033, 24508459, 23559371 +SPOP K129E Likely Oncogenic Likely Loss-of-function 19818708, 18218622, 24990631 +SPOP F125V Likely Oncogenic Loss-of-function 19818708, 18218622, 25274033, 24508459, 23559371 +SPOP S119N Likely Oncogenic Loss-of-function 19818708, 18218622, 25274033, 24508459, 23559371 +FGFR2 Y375C Likely Oncogenic Gain-of-function 22585574, 22558232 +FGFR2 C278F Likely Oncogenic Likely Loss-of-function 20004243, 16844695 +FGFR2 H213Y Inconclusive Inconclusive 19147536 +FGFR2 K525E Likely Oncogenic Gain-of-function 17803937 +FGFR2 FGFR2-BICC1 Fusion Oncogenic Gain-of-function 24122810, 23558953 +FGFR2 V564I Oncogenic Gain-of-function 23908597 +FGFR2 FGFR2-MGEA5 Fusion Likely Oncogenic Likely Gain-of-function 24550739 +FGFR2 Amplification Oncogenic Gain-of-function 20094046, 20101236 +FGFR2 I642V Likely Oncogenic Likely Loss-of-function 19147536 +FGFR2 E219K Likely Oncogenic Likely Loss-of-function 19147536 +FGFR2 S267_D273dup Oncogenic Gain-of-function 26048680 +FGFR2 W290_I291delinsC Oncogenic Gain-of-function 26048680 +FGFR2 R203C Likely Oncogenic Gain-of-function 23527311, 15908952 +FGFR2 T341P Likely Oncogenic Gain-of-function 9539778 +FGFR2 FGFR2-FAM76A Fusion Oncogenic Gain-of-function 24563622 +FGFR2 N549T Likely Oncogenic Gain-of-function 17803937 +FGFR2 E565G Likely Oncogenic Gain-of-function 23908597 +FGFR2 FGFR2-TACC3 Fusion Oncogenic Gain-of-function 26048680 +FGFR2 FGFR2-AHCYL1 Fusion Oncogenic Gain-of-function 24122810 +FGFR2 E731K Likely Oncogenic Gain-of-function 21928350 +FGFR2 L617F Likely Oncogenic Gain-of-function 23913723 +FGFR2 M535I Oncogenic Gain-of-function 23908597 +FGFR2 K659N Likely Oncogenic Gain-of-function 17803937, 23527311, 17525745 +FGFR2 T730S Likely Neutral Likely Neutral 26048680 +FGFR2 L770V Inconclusive Inconclusive 19147536 +FGFR2 K517R Likely Neutral Likely Loss-of-function 19147536 +FGFR2 G271E Likely Oncogenic Likely Loss-of-function 19147536 +FGFR2 N549K Oncogenic Gain-of-function 23908597, 17525745, 18552176 +FGFR2 K310R Likely Neutral Likely Neutral 18552176 +FGFR2 L617M Oncogenic Gain-of-function 23908597 +FGFR2 N549H Oncogenic Gain-of-function 23908597 +FGFR2 D530N Likely Oncogenic Likely Loss-of-function 19147536 +FGFR2 A648T Likely Oncogenic Likely Loss-of-function 19147536 +FGFR2 K659E Likely Oncogenic Likely Gain-of-function 17525745 +FGFR2 D101Y Likely Oncogenic Likely Gain-of-function 18552176 +FGFR2 K526E Likely Oncogenic Likely Gain-of-function 17803937, 16061565 +FGFR2 C382R Oncogenic Gain-of-function 9136983, 17525745 +FGFR2 P253R Oncogenic Gain-of-function 24265351, 11121055 +FGFR2 N549S Oncogenic Gain-of-function 23908597 +FGFR2 FGFR2-KIAA1967 Fusion Likely Oncogenic Likely Gain-of-function 23558953 +FGFR2 Fusions Likely Oncogenic Likely Gain-of-function 25608663, 26258846, 23558953 +FGFR2 K641N Likely Oncogenic Likely Gain-of-function 23908597 +FGFR2 S252W Oncogenic Gain-of-function 17525745, 18552176 +FGFR2 M391R Likely Oncogenic Gain-of-function 24908667 +FGFR2 FGFR2-CCDC6 Fusion Likely Oncogenic Gain-of-function 23558953 +FGFR2 A389T Likely Neutral Likely Neutral 18552176 +FGFR2 V248D Inconclusive Inconclusive 19147536 +FGFR2 V755I Likely Neutral Likely Neutral 26048680 +FGFR2 FGFR2-CIT Fusion Likely Oncogenic Likely Gain-of-function 23558953 +FGFR2 G701S Inconclusive Inconclusive 19147536 +FGFR2 E475K Likely Neutral Likely Neutral 19147536 +FGFR2 FGFR2?PPHLN1 Fusion Oncogenic Gain-of-function 25608663 +FGFR2 R251Q Likely Oncogenic Likely Loss-of-function 19147536 +FGFR2 K641R Likely Oncogenic Gain-of-function 17803937, 23527311 +FGFR2 E636K Inconclusive Inconclusive 19147536 +FGFR4 Y367C Oncogenic Gain-of-function 19946327 +FGFR4 Amplification Oncogenic Gain-of-function 15863030, 25053532, 20094046, 23344261 +FGFR4 V550E Oncogenic Gain-of-function 19809159, 25219510 +FGFR4 N535K Oncogenic Gain-of-function 19809159 +KDM6A Deletion Likely Oncogenic Likely Loss-of-function 19330029, 25225064, 27028180, 22197486 Walker et al. Abstract #1798, ASH, 2009 http://www.bloodjournal.org/content/114/22/1798?sso-checked=true +KDM6A Truncating Mutations Likely Oncogenic Likely Loss-of-function 19330029, 24633898, 25225064 +ALK I1183T Likely Neutral Neutral 21383740, 25517749 +ALK G1202R Oncogenic Gain-of-function 22277784, 21383740, 26144315, 26698910, 24736079, 24675041 +ALK RANBP2-ALK Fusion Oncogenic Gain-of-function 21030459, 20979472 +ALK G1269S Oncogenic Gain-of-function 22277784, 21383740, 22034911, 24675041 +ALK L1198P Oncogenic Gain-of-function 21948233, 21383740 +ALK L1122V Oncogenic Gain-of-function 21383740, 25421750 +ALK I1171N Oncogenic Gain-of-function 21383740, 25517749, 27049722, 24491302, 25749034 +ALK T1343I Likely Neutral Likely Neutral 21383740, 25517749 +ALK S1206Y Oncogenic Gain-of-function 22277784, 21383740, 26144315, 24675041 +ALK N1178H Oncogenic Gain-of-function 21383740, 25749034 +ALK P1139S Oncogenic Gain-of-function 21383740, 25421750 +ALK RANBP1-ALK Fusion Oncogenic Gain-of-function 21030459 +ALK D1091N Likely Oncogenic Likely Gain-of-function 21383740, 18923525, 23104988, 26786851, 18724359 +ALK H694R Likely Oncogenic Gain-of-function 21847362 +ALK R1192P Oncogenic Gain-of-function 27009859, 21383740, 25517749, 27049722 +ALK G1269A Oncogenic Gain-of-function 22235099, 27009859, 26849637, 23401436, 21948233, 22277784, 21383740, 27049722, 26144315, 26698910, 24675041 +ALK R1464* Likely Neutral Neutral 21383740, 23104988 +ALK S1206C Oncogenic Gain-of-function 21383740, 25421750 +ALK A1234T Likely Neutral Likely Neutral 21383740, 23104988 +ALK V597A Likely Oncogenic Gain-of-function 21847362, 12855999 +ALK R1275L Likely Oncogenic Likely Gain-of-function 23598171 +ALK G1128S Oncogenic Gain-of-function 25749034 +ALK L1240V Oncogenic Gain-of-function 21383740, 23104988 +ALK G1201E Oncogenic Gain-of-function 21383740, 21596819 +ALK R1275Q Oncogenic Gain-of-function 18923523, 21383740, 18923525, 25517749, 26829053, 27049722, 26554404, 22072639 +ALK D1349H Likely Neutral Likely Neutral 21383740, 25517749 +ALK L1152R Oncogenic Gain-of-function 21791641, 21383740, 26144315 +ALK STRN-ALK Fusion Likely Oncogenic Likely Gain-of-function 24613930 +ALK G1128A Oncogenic Gain-of-function 21383740, 25517749, 27049722 +ALK L1196M Oncogenic Gain-of-function 22235099, 23434628, 22277784, 21383740, 25517749, 26144315, 20979473, 26698910, 22034911, 25421750, 21613408, 24675041 +ALK NPM-ALK Fusion Oncogenic Gain-of-function 26133723, 18923525, 26144315, 12424201, 25421750, 12879008, 21613408 +ALK G881D Likely Oncogenic Gain-of-function 21847362 +ALK F1245V Oncogenic Gain-of-function 21383740, 25517749 +ALK C1156F Oncogenic Gain-of-function 21383740, 25749034 +ALK C1156Y Oncogenic Gain-of-function 22235099, 21383740, 26144315, 20979473, 26698910, 25749034, 21613408, 24675041 +ALK Q1064R Oncogenic Gain-of-function 21383740, 25421750 +ALK G1123D Oncogenic Gain-of-function 21948233, 21383740 +ALK I1170S Oncogenic Gain-of-function 21383740, 25517749 +ALK I1250T Likely Neutral Likely Neutral 21383740, 25517749 +ALK E1384K Likely Oncogenic Gain-of-function 21847362 +ALK L1204F Likely Neutral Neutral 21383740, 23104988 +ALK M1328I Oncogenic Gain-of-function 21383740, 24491302 +ALK F1174V Oncogenic Gain-of-function 18923523, 21383740, 27049722, 25421750 +ALK I1171T Oncogenic Gain-of-function 25228534, 21383740, 22034911, 25749034, 24675041, 25736571 +ALK G1286R Likely Neutral Neutral 21383740, 25517749 +ALK I1170N Oncogenic Gain-of-function 21383740, 25517749 +ALK K1062M Oncogenic Gain-of-function 21383740, 21596819, 18923524 +ALK D1203N Likely Oncogenic Likely Gain-of-function 21948233, 25421750, 25749034 +ALK E1210K Oncogenic Gain-of-function 21383740, 22034911 +ALK T1151R Likely Oncogenic Likely Gain-of-function 25071110, 21383740 +ALK KIF5B-ALK Fusion Likely Oncogenic Gain-of-function 26144315, 21613408 +ALK Fusions Likely Oncogenic Likely Gain-of-function 24060861 +ALK F1174S Oncogenic Gain-of-function 21383740, 23104988 +ALK D1270G Likely Neutral Neutral 21383740, 25517749 +ALK Amplification Likely Oncogenic Likely Gain-of-function 21474455, 24356251, 22614325 +ALK F1245C Oncogenic Gain-of-function 21383740, 25517749, 27049722, 26554404, 22034911, 23598171 +ALK A1200V Likely Neutral Neutral 21383740, 23104988 +ALK L1198F Oncogenic Gain-of-function 21383740, 21596819, 26698910, 25421750 +ALK Y1278S Oncogenic Gain-of-function 25071110, 21383740, 25517749, 27049722, 23598171 +ALK F1174L Oncogenic Gain-of-function 21383740, 25517749, 22072639, 18724359, 21030459, 18923523, 27009859, 21948233, 21596819, 20719933, 18923525, 27049722, 26144315, 26554404, 23104988, 18923524, 26786851, 21242967, 21613408 +ALK R1060H Likely Neutral Neutral 21383740, 23104988 +ALK EML4-ALK Fusion Oncogenic Gain-of-function 21030459, 22235099, 25228534, 21791641, 21948233, 22277784, 18923524, 21613408, 24675041 +ALK V1180L Oncogenic Gain-of-function 25228534, 21383740 +ALK M1166R Oncogenic Gain-of-function 21383740, 25517749, 23104988 +ALK G1123S Oncogenic Gain-of-function 21948233, 21383740 +ALK L1152P Oncogenic Gain-of-function 21383740, 24675041 +ALK T1151M Likely Neutral Likely Neutral 27009859, 21383740, 18923525, 25517749, 23104988 +ALK T1151dup Oncogenic Gain-of-function 22277784, 21383740, 26144315, 24675041 +ALK R1231Q Likely Neutral Neutral 21383740, 23104988 +ALK A1099T Likely Neutral Neutral 21383740, 23104988 +ALK I1171S Oncogenic Gain-of-function 27009859, 21383740, 26464158 +ALK S1206R Oncogenic Gain-of-function 21383740, 22034911 +ALK F1174I Oncogenic Gain-of-function 21383740, 23104988, 25749034 +ALK L1196Q Oncogenic Gain-of-function 23239810 +ALK CAD-ALK Fusion Likely Oncogenic Likely Gain-of-function 26633560 +ALK F1174C Oncogenic Gain-of-function 21383740, 26698910, 22034911, 24675041 +ALK T1087I Likely Neutral Neutral 21383740, 23104988 +SDHB S100F Likely Oncogenic Loss-of-function 17639058, 15987702 +RAD54L G325R Likely Oncogenic Loss-of-function 15056673, 10362365 +SDHC R133* Likely Oncogenic Loss-of-function 24423348 +VEGFA Amplification Likely Oncogenic Gain-of-function 24687604, 21743435, 24114200, 21495021 +MPL S505N Likely Oncogenic Likely Gain-of-function 14764528, 8695859 +MPL W515L Oncogenic Gain-of-function 16834459 +MPL W515K Likely Oncogenic Likely Gain-of-function 16868251, 17709604 +MPL P106L Likely Oncogenic Likely Gain-of-function 25538044, 23351976 +PMS1 Q233* Oncogenic Loss-of-function 8072530 +CARM1 S217E Likely Oncogenic Likely Loss-of-function 19843527 +CARM1 S217C Likely Oncogenic Likely Loss-of-function 19843527 +CARM1 S217T Likely Oncogenic Likely Loss-of-function 19843527 +CARM1 S217A Likely Oncogenic Likely Loss-of-function 19843527 +FOXO1 T24A Likely Oncogenic Likely Loss-of-function 17646672, 16670091 +VHL H115R Likely Oncogenic Loss-of-function 24969085 +VHL L158P Likely Oncogenic Loss-of-function 10535940, 10973499, 19602254 +VHL N90I Likely Oncogenic Loss-of-function 10823831 +VHL S111C Likely Oncogenic Loss-of-function 22071692 +VHL R167Q Oncogenic Loss-of-function 10535940, 24755468, 19030229 +VHL L188Q Likely Oncogenic Loss-of-function 19602254 +VHL L63P Likely Oncogenic Loss-of-function 15611064 +VHL Y98N Likely Oncogenic Likely Loss-of-function 10823831, 10535940 +VHL P25L Likely Neutral Likely Neutral 16884327 +VHL L188V Likely Oncogenic Likely Loss-of-function 10823831 +VHL V84L Inconclusive Inconclusive 10823831 +VHL Truncating Mutations Likely Oncogenic Likely Loss-of-function 21386872, 12050673, 12004076, 22825683 +VHL F119S Likely Oncogenic Likely Loss-of-function 14636579 +VHL S68W Likely Oncogenic Loss-of-function 18544564, 15611064 +VHL Deletion Oncogenic Likely Loss-of-function 21386872, 23632291, 25093046, 19764026 +VHL L158V Likely Oncogenic Loss-of-function 19602254 +VHL L128F Likely Neutral Likely Neutral 11865071 +VHL P86H Likely Oncogenic Loss-of-function 10823831, 10535940 +VHL R167W Oncogenic Loss-of-function 25563310, 14973063, 23824745, 12202531 +VHL V155A Likely Oncogenic Loss-of-function 26503325 +VHL A149P Likely Oncogenic Likely Loss-of-function 14636579 +VHL L118P Likely Oncogenic Likely Loss-of-function 14636579 +VHL R64P Likely Oncogenic Loss-of-function 10823831, 15611064 +VHL I151S Likely Oncogenic Likely Loss-of-function 14636579, 27179072 +VHL N150K Likely Oncogenic Likely Loss-of-function 14636579 +VHL L118R Likely Oncogenic Likely Loss-of-function 14636579 +VHL Y112H Likely Oncogenic Likely Loss-of-function 10823831 +VHL S65L Likely Oncogenic Loss-of-function 15611064 +VHL S65A Likely Oncogenic Likely Loss-of-function 26619011, 15611064 +VHL Q164R Likely Oncogenic Loss-of-function 26503325 +VHL Q96P Likely Oncogenic Loss-of-function 10823831 +VHL W117C Likely Oncogenic Loss-of-function 14636579 +VHL R82P Likely Oncogenic Loss-of-function 10823831 +VHL Q145H Likely Neutral Loss-of-function 15611064 +VHL N78S Likely Oncogenic Loss-of-function 19602254 +VHL D121G Likely Oncogenic Likely Loss-of-function 26619011, 11865071 +VHL L158Q Likely Oncogenic Loss-of-function 2706960 +VHL E70K Likely Oncogenic Likely Loss-of-function 15611064 +VHL R69C Likely Oncogenic Loss-of-function 15611064 +VHL G114R Likely Oncogenic Likely Loss-of-function 14636579, 27179072 +VHL H191D Oncogenic Loss-of-function 21685897 +VHL S65W Likely Oncogenic Loss-of-function 15611064 +VHL H115Q Likely Oncogenic Likely Loss-of-function 24969085, 12202531 +VHL Y98H Likely Oncogenic Likely Loss-of-function 10823831 +VHL R200W Oncogenic Loss-of-function 21685897 +MAP2K4 R304* Likely Oncogenic Loss-of-function 21896780 +MAP2K4 R134Q Likely Oncogenic Likely Gain-of-function 21896780, 26619011 +MAP2K4 N234I Oncogenic Loss-of-function 20668451, 15122334 +MAP2K4 R154W Oncogenic Loss-of-function 20668451, 15122334 +MAP2K4 S251N Oncogenic Loss-of-function 20668451, 15122334 +MAP2K4 Truncating Mutations Likely Oncogenic Likely Loss-of-function 21896780 +MAP2K4 R228K Oncogenic Loss-of-function 20668451, 15122334 +MAP2K4 A279T Oncogenic Loss-of-function 21896780, 20668451, 15122334 +MAP2K4 V321M Likely Oncogenic Loss-of-function 21896780 +MAP2K4 P326L Likely Oncogenic Loss-of-function 21896780 +MAP2K4 G85R Oncogenic Loss-of-function 20668451, 15122334 +RRAS2 Q72L Oncogenic Gain-of-function 8052619 +FLT1 Amplification Inconclusive Inconclusive Zehir A et al. Nature Medicine, 2017 http://doi:10.1038/nm.4333 +FLT3 D835Y Oncogenic Gain-of-function 11290608, 23631653, 15256420, 26108694, 24255108 +FLT3 V592G Oncogenic Gain-of-function 18068628 +FLT3 D835V Oncogenic Gain-of-function 11290608, 15256420, 26108694 +FLT3 Y599_D600insPAPQIMSTSTLISENMNIA Oncogenic Gain-of-function 9737679, 11090077, 23631653 +FLT3 K602_W603insYEYDLK Oncogenic Gain-of-function 9737679, 11090077, 23631653 +FLT3 E598_Y599insGLVQVTGSSDNEYFYVDFREYE Oncogenic Gain-of-function 9737679, 11090077, 23631653, 11756186 +FLT3 F594L Oncogenic Gain-of-function 16410449 +FLT3 M664I Likely Oncogenic Likely Gain-of-function 25847190 +FLT3 I867S Oncogenic Gain-of-function 24608088 +FLT3 Y599F Likely Neutral Likely Loss-of-function 16684964 +FLT3 W603_E604insDREYEYDLKW Oncogenic Gain-of-function 9737679, 11090077, 23631653 +FLT3 E612_F613insGYVDFREYEYDLKWEFRPRENLEF Oncogenic Gain-of-function 9737679, 11090077, 23631653, 11756186 +FLT3 D835E Oncogenic Gain-of-function 11290608, 15256420, 26108694 +FLT3 V194M Likely Neutral Neutral 18068628 +FLT3 D324N Likely Neutral Neutral 18068628 +FLT3 E598_Y599insDVDFREYE Oncogenic Gain-of-function 9737679, 11090077, 23631653 +FLT3 A627T Likely Oncogenic Likely Gain-of-function 15374944 +FLT3 I836del Likely Oncogenic Gain-of-function 23878140 +FLT3 D835H Oncogenic Gain-of-function 11290608, 15256420, 26108694 +FLT3 F594_R595insSDNEYFYVDF Oncogenic Gain-of-function 9737679, 11090077, 23631653 +FLT3 S451F Oncogenic Gain-of-function 18068628 +FLT3 Y591D Oncogenic Gain-of-function 16410449 +FLT3 V592A Oncogenic Gain-of-function 16410449 +FLT3 N676K Oncogenic Gain-of-function 23878140 +FLT3 L601_K602insREYEYDL Oncogenic Gain-of-function 9737679, 11090077, 23631653, 11756186 +FLT3 T167A Likely Neutral Neutral 18068628 +FLT3 S840_N841insGS Oncogenic Gain-of-function 9737679, 11090077, 23631653, 12384447 +FLT3 D835del Oncogenic Gain-of-function 15256420 +FLT3 Y364H Likely Neutral Neutral 18068628 +FLT3 K868N Likely Neutral Loss-of-function 27272783 +FLT3 N841I Oncogenic Gain-of-function 15178581 +FLT3 Y572C Oncogenic Gain-of-function 18068628 +FLT3 V557I Likely Neutral Neutral 18068628 +FLT3 D835N Oncogenic Gain-of-function 11290608, 15256420, 26108694 +FLT3 F590G Oncogenic Gain-of-function 16410449 +FLT3 D839G Oncogenic Gain-of-function 24608088 +FLT3 Y599_D600insSTDNEYFYVDFREYEY Oncogenic Gain-of-function 9737679, 11090077, 23631653 +FLT3 N676S Likely Oncogenic Likely Gain-of-function 25847190 +FLT3 V579A Oncogenic Gain-of-function 16410449 +FLT3 D600_L601insDFREYEYD Oncogenic Gain-of-function 9737679, 11090077, 23631653 +FLT3 Y599_D600insEYEYEYEY Oncogenic Gain-of-function 9737679, 11090077, 23631653 +FLT3 D835A Oncogenic Gain-of-function 11290608, 15256420, 26108694 +FLT3 L611_E612insCSSDNEYFYVDFREYEYDLKWEFPRENL Oncogenic Gain-of-function 9737679, 11090077, 23631653, 11756186 +FLT3 R834Q Oncogenic Gain-of-function 18068628 +FLT3 Amplification Likely Oncogenic Gain-of-function 25848357, 27906677 +FLT3 FLT3 internal tandem duplications Oncogenic Gain-of-function 23631653 +FLT3 N676D Likely Oncogenic Likely Gain-of-function 22875611 +FLT3 S451E Oncogenic Gain-of-function 18068628 +FLT3 F691L Oncogenic Gain-of-function 19318574, 23430109 +FLT3 Y842C Oncogenic Gain-of-function 15345593 +FLT3 G831E Likely Neutral Neutral 18068628 +FLT3 M737I Likely Neutral Neutral 18068628 +FLT3 Y599_D600insGLYVDFREYEY Oncogenic Gain-of-function 9737679, 11090077, 23631653, 11756186 +FLT3 D600_L601insFREYEYD Oncogenic Gain-of-function 9737679, 11090077, 23631653 +PMS2 G207E Likely Oncogenic Likely Loss-of-function 19479271, 24027009 +PMS2 T485K Likely Neutral Likely Neutral 15256438, 24362816, 24027009 +PMS2 Truncating Mutations Likely Oncogenic Likely Loss-of-function 12697830, 20487569, 23582141, 21376568, 7892206, 16144131, 9488480 +PMS2 R20Q Oncogenic Loss-of-function 25512458 +PMS2 G857A Likely Neutral Likely Neutral 24362816, 24027009 +PMS2 L585I Likely Neutral Likely Neutral 24362816, 24027009 +PMS2 R802* Likely Oncogenic Likely Loss-of-function 24362816, 16507833 +PMS2 R421* Likely Oncogenic Likely Loss-of-function 24362816 +PMS2 I668V Oncogenic Loss-of-function 25691505 +PMS2 E541K Likely Neutral Likely Neutral 24362816, 24027009 +PMS2 E41A Oncogenic Loss-of-function 20864418, 24027009 +PMS2 R315* Likely Oncogenic Likely Loss-of-function 24362816 +PMS2 S46I Oncogenic Loss-of-function 18602922, 25883011, 23709753, 17557300, 24027009, 2257789, 18709565, 16144131 +PMS2 P470S Likely Neutral Likely Neutral 24362816, 24027009 +PMS2 S46N Oncogenic Loss-of-function 24027009 +PMS2 Deletion Likely Oncogenic Likely Loss-of-function 18602922, 23837913, 16472587 +PMS2 E5K Likely Neutral Likely Neutral 24362816 +PMS2 I18V Likely Neutral Neutral 24362816, 24027009 +SRSF2 P95H Oncogenic Loss-of-function 27135740, 25965569, 26124281, 26261309 +WHSC1 E1099K Oncogenic Gain-of-function 23823660, 24076604 +PPM1D 422_605trunc Likely Oncogenic Gain-of-function 25742468, 24880341, 23907125 +POLD1 Truncating Mutations Likely Oncogenic Likely Loss-of-function +POLE L424V Likely Oncogenic Loss-of-function 23263490, 25228659 +POLE P286H Likely Oncogenic Loss-of-function 25228659 +POLE S459F Likely Oncogenic Loss-of-function 25228659 +POLE S279Y Likely Oncogenic Likely Loss-of-function 25228659, 24472300 +POLE F367S Likely Oncogenic Loss-of-function 21157497, 25228659 +POLE P286S Likely Oncogenic Loss-of-function 25228659 +POLE L424I Likely Oncogenic Loss-of-function 25228659 +POLE V411L Likely Oncogenic Loss-of-function 25228659, 23636398 +POLE S297F Likely Oncogenic Likely Loss-of-function 25228659, 24472300 +POLE S459del Likely Oncogenic Likely Loss-of-function 25228659 +POLE P286R Likely Oncogenic Loss-of-function 25228659, 23636398 +KNSTRN R11K Likely Oncogenic Likely Loss-of-function 25194279 +KNSTRN S24F Oncogenic Loss-of-function 25194279 +KNSTRN P26S Likely Oncogenic Likely Loss-of-function 25194279 +KNSTRN A40E Likely Oncogenic Likely Loss-of-function 25194279 +KNSTRN P28S Likely Oncogenic Likely Loss-of-function 25194279 +PIK3R3 Truncating Mutations Likely Oncogenic Likely Loss-of-function 25424831, 27766312 +APC Truncating Mutations Likely Oncogenic Likely Loss-of-function 11062151, 15561772, 11257105 +APC R640G Oncogenic Loss-of-function 19111562 +APC Deletion Likely Oncogenic Likely Loss-of-function 8259511, 15643602, 25317407, 11867715 +APC N1026S Likely Oncogenic Loss-of-function 18166348 +APC I1307K Likely Oncogenic Likely Loss-of-function 9724771 +APC A290T Likely Oncogenic Likely Loss-of-function 11606402 +RICTOR Amplification Oncogenic Gain-of-function 19934294, 20978191, 26370156, 19185849 +MSH2 Deletion Likely Oncogenic Likely Loss-of-function 9823339, 21970482, 22781090, 23264089, 17250661 +MSH2 Q395* Oncogenic Loss-of-function 24362816 +MSH2 G322D Likely Neutral Likely Neutral 24362816 +MSH2 R389* Oncogenic Loss-of-function 19459153, 26864202, 25430799 +MSH2 Q337* Oncogenic Loss-of-function 24362816 +MSH2 A636P Likely Oncogenic Likely Loss-of-function 12595050, 10528862 +MSH2 R711* Oncogenic Loss-of-function 24362816 +MSH2 R680* Oncogenic Loss-of-function 24362816 +MSH2 L390F Likely Neutral Likely Neutral 24362816 +MSH2 A272V Likely Neutral Likely Neutral 17101317, 21120944 +MSH2 D603N Oncogenic Loss-of-function 21120944, 18951462 +MSH2 S860L Likely Neutral Likely Neutral 24362816, 22102614 +MSH2 S723F Likely Oncogenic Likely Loss-of-function 24362816, 22102614, 26951660 +MSH2 G751R Likely Oncogenic Loss-of-function 24362816, 10732761, 17720936 +MSH2 Truncating Mutations Likely Oncogenic Likely Loss-of-function 11257106, 23391514, 15528792, 10946232 +MSH2 Q429* Oncogenic Loss-of-function 7726159 +MSH2 E580* Oncogenic Loss-of-function 24362816 +MSH2 R383* Oncogenic Loss-of-function 8592341 +MSH2 D603G Inconclusive Inconclusive 24362816 +MSH2 R621* Oncogenic Loss-of-function 8566964 +MSH2 W345* Oncogenic Loss-of-function 24362816 +MSH2 Q816* Oncogenic Loss-of-function 24362816 +MSH2 E483* Oncogenic Loss-of-function 24362816 +IDH1 R132G Oncogenic Switch-of-function 23264629, 23630074, 19935646 +IDH1 G97D Likely Oncogenic Switch-of-function 21996744 +IDH1 E190K Likely Neutral Likely Neutral 27147599 +IDH1 G70D Likely Neutral Loss-of-function 21996744 +IDH1 H133Q Likely Neutral Likely Neutral 21996744 +IDH1 A134D Likely Neutral Loss-of-function 21996744 +IDH1 R132H Oncogenic Switch-of-function 25730874, 23393090, 22763442, 22343901, 23630074, 22343889, 22899282, 19935646 +IDH1 I99M Likely Neutral Likely Neutral 21996744 +IDH1 P33S Likely Neutral Likely Neutral 27147599 +IDH1 Y139D Likely Oncogenic Gain-of-function 21996744 +IDH1 R132S Likely Oncogenic Switch-of-function 21760534, 25257301, 23630074, 21912393, 22033490, 19935646 +IDH1 R49C Likely Neutral Loss-of-function 21996744 +IDH1 R132C Oncogenic Switch-of-function 23630074, 23954893, 19935646 +IDH1 V294M Likely Neutral Likely Neutral 21996744 +IDH1 G123R Likely Neutral Loss-of-function 20171178 +IDH1 R100A Likely Oncogenic Switch-of-function 21996744 +IDH1 I130M Likely Neutral Likely Neutral 21996744 +IDH1 R132Q Likely Oncogenic Likely Switch-of-function 25730874, 23630074, 19935646 +IDH2 R172M Likely Oncogenic Likely Switch-of-function 27147599, 20171147 +IDH2 R172K Oncogenic Switch-of-function 20171147, 25043045 +IDH2 R172G Likely Oncogenic Likely Switch-of-function 21641335, 20171147 +IDH2 R140Q Oncogenic Switch-of-function 20692206, 23264629, 20171147, 25043045, 24440599, 20847235 +IDH2 R172S Oncogenic Switch-of-function 23264629, 20171147 +XPO1 E571K Likely Oncogenic Likely Gain-of-function 21741593, 21642962, 27312795, 26619011, 27479820 +XPO1 C528S Inconclusive Inconclusive 27680702, 23034282 +XRCC2 Deletion Likely Neutral Likely Loss-of-function 22464251, 14678973, 10517641 +XRCC2 R188H Likely Oncogenic Likely Loss-of-function 12023985 +XRCC2 Truncating Mutations Likely Oncogenic Likely Loss-of-function 22464251, 14678973, 10517641 +CREBBP W1502A Likely Oncogenic Loss-of-function 11691934, 21390130 +CREBBP Deletion Likely Oncogenic Likely Loss-of-function 21390130 +CREBBP R1563S Likely Neutral Likely Neutral 21390130 +CREBBP Truncating Mutations Likely Oncogenic Likely Loss-of-function 21390130 +CREBBP R1446C Likely Oncogenic Likely Loss-of-function 21390130 +CREBBP Q1500P Likely Neutral Likely Neutral 21390130 +CREBBP R1446H Likely Oncogenic Likely Loss-of-function 21390130 +DIS3 R780K Oncogenic Loss-of-function 26193331, 24150935 +AR F877L Oncogenic Gain-of-function 23779130, 23842682, 23580326 +AR G248V Inconclusive Inconclusive 25500996 +AR L57Q Likely Neutral Loss-of-function 22403669 +AR G216R Inconclusive Inconclusive 25500996 +AR W742C Oncogenic Gain-of-function 12517791 +AR T878A Oncogenic Gain-of-function 9092797, 2260966, 10363963, 9815822, 25320358 +AR A159T Likely Neutral Likely Loss-of-function 25500996 +AR T878S Oncogenic Gain-of-function 9092797, 2260966, 9815822 +AR Q58_Q59insL Likely Neutral Likely Loss-of-function 25500996 +AR P380R Inconclusive Inconclusive 25500996 +AR Amplification Oncogenic Gain-of-function 7795646, 7511045, 11306464, 12888829, 14702632, 10496349 +AR F876L Likely Oncogenic Likely Gain-of-function 23779130, 2384268 +AR Q58L Inconclusive Inconclusive 12801573, 23637914, 24737579 +AR AR-V7 Oncogenic Gain-of-function 20823238, 19117982, 24449822, 22014572, 23851510, 21552559, 19244107, 20644256 +AR L702H Oncogenic Gain-of-function 11956172, 10835690 +AR W742L Oncogenic Gain-of-function 12517791 +AR H875Y Oncogenic Gain-of-function 9092797, 9815822 +AR L272F Likely Neutral Likely Neutral 25500996 +AR N235K Likely Neutral Likely Loss-of-function 25500996, 11422119 +AR ARv567es Oncogenic Gain-of-function 20823238, 19117982, 24449822, 22014572, 23851510, 21552559, 19244107, 20644256 +AR L57del Likely Neutral Likely Neutral 25500996 +AR Q120E Likely Neutral Likely Neutral 25500996 +ARAF S214F Oncogenic Gain-of-function 24569458, 15520807 +ARAF F351L Oncogenic Gain-of-function 24652991 +ARAF S214C Oncogenic Gain-of-function 24569458, 15520807 +ARAF G322S Likely Oncogenic Gain-of-function 25608663, 24569458 +ARAF S214A Likely Oncogenic Likely Gain-of-function 24569458, 26566875, 15520807 +ARAF Q347_A348del Oncogenic Gain-of-function 24652991 +ARAF S214T Likely Oncogenic Gain-of-function 24569458, 15520807 +ARAF N217I Oncogenic Gain-of-function 25608663, 15520807 +RHOA G17V Oncogenic Loss-of-function 24413737, 24584070 +RHOA E40L Likely Oncogenic Likely Gain-of-function 26619011, 9482732 +RHOA T37A Likely Oncogenic Likely Gain-of-function 19147561, 15993039 +RHOA G17E Likely Oncogenic Likely Loss-of-function 24816255 +RHOA Amplification Oncogenic Gain-of-function 10213513, 15448013, 25104222 +RHOA Overexpression Oncogenic Gain-of-function 10213513, 15448013, 25104222 +RHOA E40Q Likely Oncogenic Likely Gain-of-function 26619011, 9565577 +RHOA Y34F Likely Oncogenic Likely Switch-of-function 24398689, 26619011 +RHOA E40T Likely Oncogenic Likely Gain-of-function 26619011, 9482732 +RHOA Y34C Likely Oncogenic Likely Gain-of-function 26619011, 9565577 +RHOA L57V Oncogenic Loss-of-function 24816253 +RHOA Y42C Oncogenic Loss-of-function 9482732, 24816253, 24816255 +RHOA E40W Likely Oncogenic Likely Loss-of-function 26619011, 9482732 +RHOA G17A Likely Oncogenic Loss-of-function 22491204, 12221096, 16472675 +RHOA G14V Likely Neutral Loss-of-function 24584070, 19515453 +RHOA E40N Likely Oncogenic Likely Switch-of-function 26619011, 9482732 +RHOA T19N Likely Oncogenic Loss-of-function 19147561, 24584070 +RHOA R5Q Likely Oncogenic Likely Loss-of-function 25044415 +NCOR1 Truncating Mutations Likely Oncogenic Likely Loss-of-function 21102521, 7566114 +PPP2R1A R183P Likely Oncogenic Likely Loss-of-function 17174897, 17086192, 18922469 +PPP2R1A S256F Likely Oncogenic Likely Loss-of-function 21435433, 17174897, 17086192, 18922469 +PPP2R1A W257C Likely Oncogenic Likely Loss-of-function 21435433, 17174897, 17086192, 18922469 +PPP2R1A R183Q Likely Oncogenic Likely Loss-of-function 17174897, 17086192, 18922469 +PPP2R1A P179L Likely Oncogenic Likely Loss-of-function 17174897, 17086192, 18922469 +PPP2R1A S256W Likely Oncogenic Likely Loss-of-function 21435433, 17174897, 17086192, 18922469 +PPP2R1A R183W Likely Oncogenic Likely Loss-of-function 17174897, 17086192, 18922469 +PPP2R1A S256Y Likely Oncogenic Likely Loss-of-function 21435433, 17174897, 17086192, 18922469 +PPP2R1A W257G Likely Oncogenic Gain-of-function 21435433, 17174897, 17086192, 18922469, 27272709 +PPP2R1A R258C Inconclusive Inconclusive 17174897, 17086192, 18922469 +PPP2R1A R182W Likely Oncogenic Likely Loss-of-function 21435433, 17174897, 17086192, 18922469, 26168268 +PPP2R1A R258H Inconclusive Inconclusive 17174897, 17086192, 18922469 +PPP2R1A P179R Likely Oncogenic Likely Loss-of-function 17174897, 17086192, 18922469 +PPP2R1A R183G Likely Oncogenic Likely Loss-of-function 17174897, 17086192, 18922469 +SETD2 Deletion Oncogenic Loss-of-function 27282254 McKinney et al. Abstract #1052, ASH 2016 https://ash.confex.com/ash/2016/webprogram/Paper96954.html +SETD2 R1625C Oncogenic Loss-of-function 27528607 +SETD2 Truncating Mutations Likely Oncogenic Likely Loss-of-function 24509477, 25728682, 23417712 +IGF1R G119T Likely Oncogenic Loss-of-function 23045302 +IGF1R G1125A Likely Neutral Likely Loss-of-function 20103656 +IGF1R M1255I Likely Oncogenic Likely Gain-of-function 22778948 +IGF1R A1374V Likely Oncogenic Likely Gain-of-function 22778948 +PPP6C R264C Likely Oncogenic Loss-of-function 23729733 +PPP6C P186S Likely Oncogenic Loss-of-function 23729733 +PPP6C H114Y Oncogenic Loss-of-function 23729733 +PPP6C S270L Likely Oncogenic Loss-of-function 23729733 +CTCF H284Y Likely Oncogenic Likely Loss-of-function 11782357, 24794443, 26619011 +CTCF H284N Likely Oncogenic Likely Loss-of-function 11782357, 24794443, 26619011 +CTCF H284P Likely Oncogenic Likely Loss-of-function 11782357, 24794443, 26619011 +CTCF Deletion Likely Oncogenic Likely Loss-of-function 26330387, 24130125, 19568526 +CTCF Truncating Mutations Likely Oncogenic Likely Loss-of-function 25079317, 24130125, 23636398 +CTCF R339W Likely Oncogenic Switch-of-function 11782357 +IKBKE Amplification Likely Oncogenic Likely Gain-of-function 17574021, 25365225 +MTOR L2431P Oncogenic Gain-of-function 22397650 +MTOR R2505P Oncogenic Gain-of-function 20190810, 24631838, 26255626 +MTOR P2476L Likely Neutral Neutral 20190810 +MTOR E2288K Likely Oncogenic Gain-of-function 23322780 +MTOR T1977K Oncogenic Gain-of-function 27482884 +MTOR A1459P Likely Oncogenic Gain-of-function 24631838 +MTOR T1977R Oncogenic Gain-of-function 24631838 +MTOR R2505Q Likely Neutral Neutral 24631838 +MTOR E2419K Oncogenic Gain-of-function 24625776 +MTOR C1483Y Oncogenic Gain-of-function 24631838 +MTOR A41S Likely Neutral Neutral 24631838 +MTOR T1977S Likely Neutral Neutral 24631838 +MTOR L2230V Oncogenic Gain-of-function 27482884 +MTOR L2427R Likely Oncogenic Gain-of-function 27713405 +MTOR S2215F Oncogenic Gain-of-function 24631838 +MTOR D2512H Likely Oncogenic Likely Gain-of-function 24631838 +MTOR A41T Likely Neutral Neutral 24631838 +MTOR A8S Likely Neutral Likely Neutral 20190810 +MTOR M2327I Likely Oncogenic Gain-of-function 27279227 +MTOR F1888L Oncogenic Gain-of-function 24631838 +MTOR R2430M Likely Neutral Neutral 24631838 +MTOR F1888I Likely Oncogenic Gain-of-function 24631838 +MTOR E2014K Likely Oncogenic Gain-of-function 24625776 +MTOR E1799K Oncogenic Gain-of-function 24631838 +MTOR F1888V Likely Neutral Neutral 24631838 +MTOR Y1463S Likely Oncogenic Likely Gain-of-function 24631838, 26255626 +MTOR V2006L Likely Oncogenic Likely Gain-of-function 24631838, 26619011 +MTOR A1519T Oncogenic Gain-of-function 24631838, 26255626 +MTOR D2512Y Likely Neutral Neutral 24631838 +MTOR K1452N Likely Oncogenic Likely Gain-of-function 24631838, 26255626 +MTOR Q2223K Oncogenic Gain-of-function 24622468 +MTOR S2215T Likely Neutral Neutral 24631838 +MTOR L1460P Oncogenic Gain-of-function 20190810, 24631838, 26255626 +MTOR C1483R Likely Oncogenic Gain-of-function 24631838 +MTOR W1456R Likely Oncogenic Likely Gain-of-function 23322780, 22460905 +MTOR P2273S Likely Oncogenic Gain-of-function 23322780 +MTOR R2152C Likely Neutral Neutral 24631838 +MTOR C1483W Likely Oncogenic Gain-of-function 24631838 +MTOR I2500F Oncogenic Gain-of-function 24631838 +MTOR A2034V Likely Oncogenic Likely Gain-of-function 27279227 +MTOR A41P Likely Neutral Neutral 24631838 +MTOR I2500M Oncogenic Gain-of-function 24631838 +MTOR V2006I Likely Oncogenic Gain-of-function 24631838 +MTOR S2215Y Oncogenic Gain-of-function 20190810, 24631838, 24336570 +MTOR L1433S Oncogenic Gain-of-function 24631838, 26255626 +MTOR R2505* Likely Neutral Neutral 24631838 +MTOR F2108L Likely Oncogenic Likely Gain-of-function 27279227 +MTOR C1483F Oncogenic Gain-of-function 24631838, 26255626 +MTOR D2512G Likely Neutral Neutral 24631838 +MTOR T1977I Likely Oncogenic Gain-of-function 26432419 +TET1 Truncating Mutations Likely Oncogenic Likely Loss-of-function 21057493, 22156206, 19372391 +TET1 MLL-TET1 Fusion Oncogenic Gain-of-function 19144982, 12646957, 23818607, 24323992 +TET1 Deletion Likely Oncogenic Likely Loss-of-function 21625234, 19420352, 25867473 +SMARCA4 Truncating Mutations Likely Oncogenic Likely Loss-of-function 24658002, 24658001, 24658004, 25060813, 18301784 +SMARCA4 T910M Likely Oncogenic Loss-of-function 26842758, 23698369 +SMARCA4 R1189* Likely Oncogenic Loss-of-function 20137775 +SMARCA4 R1093* Oncogenic Loss-of-function 24658001, 24658004 +SMARCA4 Deletion Likely Oncogenic Likely Loss-of-function 21520050, 23139211, 18381774, 11481457, 26942101, 11163203 +SMARCA4 R978* Oncogenic Loss-of-function 24658002, 24658004 +SMARCA4 G1232D Likely Oncogenic Loss-of-function 23698369 +SMARCB1 Truncating Mutations Likely Oncogenic Likely Loss-of-function 23620515, 12138206, 9671307, 23435428, 21076395 +SMARCB1 Deletion Likely Oncogenic Likely Loss-of-function 11313485, 10521299, 11095756, 23074045, 9892189, 12450796, 22797305, 11263494 +FOXP1 Truncating Mutations Likely Oncogenic Likely Loss-of-function 25329375 +FOXP1 R514C Likely Oncogenic Likely Loss-of-function 26647308 +SMO Q477E Likely Oncogenic Likely Gain-of-function 25759020, 25759019 +SMO L412F Likely Oncogenic Gain-of-function 2575902, 25759020, 25759019, 25199678 +SMO T241M Likely Oncogenic Gain-of-function 25759019 +SMO I408V Likely Oncogenic Gain-of-function 2575902, 25759020, 25759019, 25199678 +SMO W281C Likely Oncogenic Gain-of-function 25759020, 25759019, 25199678 +SMO V321M Likely Oncogenic Gain-of-function 2575902, 25759020, 25759019, 25199678 +SMO E518K Likely Neutral Likely Neutral 21123452 +SMO L221R Likely Oncogenic Likely Gain-of-function 25759020, 25759019 +SMO S387N Likely Oncogenic Gain-of-function 25759019 +SMO D384N Likely Oncogenic Likely Gain-of-function 25759020, 25759019 +SMO A459V Likely Oncogenic Gain-of-function 25759019 +SMO H231R Likely Oncogenic Likely Gain-of-function 25759020, 25759019 +SMO D473G Likely Oncogenic Likely Gain-of-function 19726788 +SMO F460L Likely Oncogenic Gain-of-function 2575902, 25759020, 25759019, 25199678 +SMO K575M Likely Oncogenic Likely Gain-of-function 16339184, 12499255 +SMO N219D Likely Oncogenic Likely Gain-of-function 25759020, 25759019 +SMO C469Y Likely Oncogenic Gain-of-function 2575902, 25759020, 25759019, 25199678 +SMO E518A Inconclusive Inconclusive 21123452 +SMO W535L Likely Oncogenic Gain-of-function 25759020, 23636324, 9422511 +SMO Amplification Inconclusive Inconclusive 24202394, 26124204, 20215540 Zehir A et al. Nature Medicine, 2017 http://doi:10.1038/nm.4333 +SMO Q635E Likely Oncogenic Likely Gain-of-function 25759020 +SMO V414A Likely Oncogenic Likely Gain-of-function 25801792, 26619011 +SMO D473H Likely Oncogenic Likely Gain-of-function 19726788 +CARD11 C49Y Likely Oncogenic Gain-of-function 25930198, 23149938 +CARD11 S250P Oncogenic Gain-of-function 23027925, 18323416, 26776161 +CARD11 L251P Oncogenic Gain-of-function 23027925, 18323416, 26776161 +CARD11 F123I Likely Oncogenic Gain-of-function 20799731, 23149938 +CARD11 L225LI Likely Oncogenic Gain-of-function 20799731, 23149938 +CARD11 G116S Likely Oncogenic Gain-of-function 23179749 +CARD11 E127G Likely Oncogenic Gain-of-function 23179749 +CARD11 L232LI Likely Oncogenic Likely Gain-of-function 23027925 +CARD11 E93D Oncogenic Gain-of-function 23149938 +CARD11 G123S Likely Oncogenic Likely Gain-of-function 23027925 +CARD11 D387V Likely Oncogenic Likely Gain-of-function 23027925 +CARD11 Amplification Likely Oncogenic Likely Gain-of-function 18323416 Abubaker et al. Abstract# 4192, AACR 2011 http://cancerres.aacrjournals.org/content/71/8_Supplement/4192 +CARD11 E626K Likely Oncogenic Gain-of-function 26551667 +CARD11 D401N Likely Oncogenic Gain-of-function 25921526 +MEF2B K4E Oncogenic Loss-of-function 23974956, 26245647 +MEF2B N81Y Oncogenic Loss-of-function 23974956 +MEF2B E77K Oncogenic Loss-of-function 23974956 +MEF2B Y69H Oncogenic Loss-of-function 23974956 +MEF2B Amplification Likely Oncogenic Likely Gain-of-function 26245647 +MEF2B D83V Oncogenic Gain-of-function 23974956, 26245647 +CTLA4 T17A Likely Oncogenic Likely Loss-of-function 15018649, 11976786, 20064370, 10082437, 8989248, 18528295, 9459504, 12244107 +ATM V2424G Likely Oncogenic Loss-of-function 18634022, 9463314 +ATM Truncating Mutations Likely Oncogenic Likely Loss-of-function 15928302, 16832357, 16998505 +ATM E1978* Likely Oncogenic Likely Loss-of-function 21514219, 18807267 +ATM D2870A Likely Oncogenic Loss-of-function 9733515, 27304073 +ATM Deletion Likely Oncogenic Likely Loss-of-function 21993670, 16014569 +ATM N2875K Likely Oncogenic Loss-of-function 9733515, 27304073 +ATM D1853N Likely Neutral Likely Neutral 20396981, 18264724, 20799949 +NUP93 G591V Likely Neutral Neutral 26878725 +NUP93 Y629C Likely Neutral Neutral 26878725 +NUP93 Exon 13 deletion Likely Oncogenic Likely Loss-of-function 26878725 +NUP93 K442Nfs* Likely Oncogenic Likely Loss-of-function 26878725 +MAPK1 Amplification Likely Oncogenic Gain-of-function 22961667 +MAPK1 E322K Likely Oncogenic Gain-of-function 24390348, 18813840, 25320010, 26551667, 26181029, 15999996, 21098038, 16324895, 16051177 +CTNNB1 S45A Oncogenic Gain-of-function 12799363 +CTNNB1 G34A Likely Oncogenic Gain-of-function 9635572, 15829978, 9065402 +CTNNB1 G34E Likely Oncogenic Gain-of-function 9635572, 10671680, 9065402 +CTNNB1 S33Y Oncogenic Gain-of-function 9635572, 24735922, 18757411, 9065402 +CTNNB1 S37Y Likely Oncogenic Gain-of-function 20606007, 9635572, 9065402 +CTNNB1 S23R Likely Oncogenic Gain-of-function 9635572, 24735922, 18282277, 9065402 Manring et al. Abstract# 2249, AACR 2012 http://cancerres.aacrjournals.org/content/72/8_Supplement/2249 +CTNNB1 D32N Likely Oncogenic Gain-of-function 9635572, 15064718, 9065402 +CTNNB1 S37C Likely Oncogenic Gain-of-function 9635572, 9537226, 9065402 +CTNNB1 S45del Likely Oncogenic Gain-of-function 9635572, 15064718, 9065402 +CTNNB1 S33F Likely Oncogenic Likely Gain-of-function 9635572, 15829978, 27543871, 18757411, 19582367, 9065402 +CTNNB1 P44A Likely Oncogenic Gain-of-function 9635572, 18282277, 9065402 +CTNNB1 S45P Likely Oncogenic Gain-of-function 9635572, 24735922, 18282277, 9065402 Manring et al. Abstract# 2249, AACR 2012 http://cancerres.aacrjournals.org/content/72/8_Supplement/2249 +CTNNB1 S37A Likely Oncogenic Gain-of-function 15579438, 9635572, 9065402 +CTNNB1 H36P Likely Oncogenic Gain-of-function 9635572, 24735922, 18282277, 9065402 Manring et al. Abstract# 2249, AACR 2012 http://cancerres.aacrjournals.org/content/72/8_Supplement/2249 +CTNNB1 D32A Likely Oncogenic Gain-of-function 15829978 +CTNNB1 I35S Likely Oncogenic Gain-of-function 12375019, 9635572, 24735922, 18282277, 9065402, 10665646 Manring et al. Abstract# 2249, AACR 2012 http://cancerres.aacrjournals.org/content/72/8_Supplement/2249 +CTNNB1 D32G Likely Oncogenic Gain-of-function 9635572, 15064718, 9065402 +CTNNB1 S33A Oncogenic Gain-of-function 15829978 +CTNNB1 S45F Likely Oncogenic Gain-of-function 9635572, 18282277, 26686699, 9065402 +CTNNB1 S33C Oncogenic Gain-of-function 9635572, 19582367, 9065402 +CTNNB1 T41A Oncogenic Gain-of-function 9635572, 24735922, 12799363, 9065402 +CTNNB1 K335I Likely Oncogenic Gain-of-function 15579438, 9635572, 24735922, 9065402 +CTNNB1 N387K Likely Oncogenic Gain-of-function 9635572, 24735922, 9065402 +CTNNB1 D32Y Likely Oncogenic Gain-of-function 9635572, 15064718, 9065402 +CTNNB1 W383R Likely Oncogenic Gain-of-function 15579438, 9635572, 9065402 +CTNNB1 S45Y Likely Oncogenic Gain-of-function 9635572, 9065402, 9419974 +CTNNB1 S37F Likely Oncogenic Gain-of-function 9635572, 22815287, 20303878, 9537226, 9065403, 9065402 +CTNNB1 G34V Likely Oncogenic Gain-of-function 9635572, 10671680, 9671767, 9065402 +MAP2K1 F53S Likely Oncogenic Gain-of-function 17981815, 16439621 +MAP2K1 G128V Likely Oncogenic Likely Gain-of-function 24265153 +MAP2K1 L115P Likely Oncogenic Likely Gain-of-function 19915144 +MAP2K1 L37P Likely Oncogenic Likely Gain-of-function 26566875 +MAP2K1 R47Q Oncogenic Gain-of-function 24982505, 22327936 +MAP2K1 D67N Oncogenic Gain-of-function 25351745, 18060073 +MAP2K1 F129L Likely Oncogenic Gain-of-function 21705440, 19915144, 26399658 +MAP2K1 E203K Oncogenic Gain-of-function 25351745, 22197931 +MAP2K1 I103N Likely Oncogenic Gain-of-function 19915144, 12370306 +MAP2K1 P124S Oncogenic Gain-of-function 24265153, 22197931, 25370473 +MAP2K1 N382H Likely Neutral Likely Neutral 22197931 +MAP2K1 P124L Likely Oncogenic Gain-of-function 19915144, 25370473 +MAP2K1 R49L Oncogenic Gain-of-function 22327936 +MAP2K1 K57E Oncogenic Gain-of-function 26566875, 25370473, 24241536 +MAP2K1 K57T Likely Oncogenic Gain-of-function 26644315 +MAP2K1 D65N Likely Neutral Likely Neutral 26566875 +MAP2K1 Q56_V60del Oncogenic Gain-of-function 26324360 +MAP2K1 E102_I103del Likely Oncogenic Gain-of-function 25351745 +MAP2K1 Q56P Oncogenic Gain-of-function 19915144, 25351745, 22327936, 26566875 +MAP2K1 E144K Likely Oncogenic Gain-of-function 26566875 +MAP2K1 Y130C Likely Oncogenic Gain-of-function 18060073, 26566875 +MAP2K1 Amplification Inconclusive Inconclusive 26399658, 26684394 +MAP2K1 H119P Inconclusive Inconclusive 19915144 +MAP2K1 F53L Oncogenic Gain-of-function 25351745, 21383288, 22197931, 26582713, 26324360, 24241536 +MAP2K1 C121S Likely Oncogenic Gain-of-function 24448821, 25351745, 21383288 +MAP2K1 V211D Inconclusive Inconclusive 19915144, 26399658 +MAP2K1 I111A Likely Oncogenic Likely Gain-of-function 12370306 +MAP2K1 Q58_E62del Likely Oncogenic Gain-of-function 26566875 +MAP2K1 V60M Likely Oncogenic Gain-of-function 26566875 +MAP2K1 F53C Likely Oncogenic Likely Gain-of-function 17981815 +MAP2K1 I111N Inconclusive Inconclusive 19915144 +MAP2K1 I111R Likely Oncogenic Likely Gain-of-function 12370306 +MAP2K1 L115R Inconclusive Inconclusive 19915144 +MAP2K1 S218D Likely Oncogenic Gain-of-function 17981815, 16439621 +MAP2K1 S222D Oncogenic Gain-of-function 17981815, 16439621 +MAP2K1 P306H Likely Oncogenic Gain-of-function 22327936 +MAP2K1 I204T Likely Oncogenic Gain-of-function 22327936 +MAP2K1 K59del Likely Oncogenic Gain-of-function 22389471 +MAP2K1 I111P Likely Oncogenic Likely Gain-of-function 12370306 +MAP2K1 P387S Likely Neutral Likely Neutral 22389471 +MAP2K1 K57N Oncogenic Gain-of-function 25351745, 18632602, 26566875 +MAP2K1 P124Q Likely Oncogenic Gain-of-function 25370473 +MAP2K1 V60E Likely Oncogenic Likely Gain-of-function 24265153 +MAP2K1 E120Q Likely Neutral Likely Neutral 26566875 +MAP2K1 S123T Likely Oncogenic Gain-of-function 26566875 +MAP2K1 K97M Likely Neutral Loss-of-function 22177953, 10567369, 16439621 +MAP2K1 T28I Likely Oncogenic Likely Gain-of-function 26566875 +MAP2K2 Q60P Oncogenic Gain-of-function 24265154, 24055054 +MAP2K2 C125S Oncogenic Gain-of-function 24265153, 21383288 +MAP2K2 F57V Likely Oncogenic Likely Gain-of-function 18042262, 18456719, 16439621 +MAP2K2 K101M Inconclusive Inconclusive 19376813, 22177953, 16439621 +MAP2K2 V35M Oncogenic Gain-of-function 24265153, 21383288 +MAP2K2 S226D Inconclusive Inconclusive 16439621 +MAP2K2 E207K Oncogenic Gain-of-function 22197931 +MAP2K2 S222D Inconclusive Inconclusive 16439621 +MAP2K2 F57C Likely Oncogenic Gain-of-function 16439621 +MAP2K2 F57L Likely Oncogenic Likely Gain-of-function 18042262, 18456719, 16439621 +MAP2K2 N126D Oncogenic Gain-of-function 25487361, 24265153 +MAP2K2 L46F Oncogenic Gain-of-function 24265153, 21383288 +SPEN Truncating Mutations Likely Oncogenic Likely Loss-of-function 26297734 +STAG2 Truncating Mutations Likely Oncogenic Likely Loss-of-function 22417201, 21852505, 24121789, 25010205 +IL7R T244_I245insCPT Oncogenic Gain-of-function 21892159 +SOS1 R552G Likely Oncogenic Gain-of-function 17143285 +SOS1 E846K Likely Oncogenic Gain-of-function 21041952, 17143285 +SOS1 R552S Likely Oncogenic Gain-of-function 27304678 +SOS1 M269R Likely Oncogenic Gain-of-function 27304678, 17143285, 25712082, 24297905 +SOS1 G434R Likely Oncogenic Likely Gain-of-function 27304678 +SOS1 N233Y Likely Oncogenic Gain-of-function 27304678 +MYC T73A Likely Oncogenic Gain-of-function 10378696, 20399964, 21266350, 18642118, 16934487, 19029958, 10706881, 22464321 +MYC IGH-MYC Fusion Oncogenic Gain-of-function 10378696, 22333947, 16934487, 19029958, 22464321 +MYC T73I Likely Oncogenic Likely Gain-of-function 20713710, 26619011, 10825194 +MYC MYC-nick Inconclusive Inconclusive 24696454, 20691906 +MYC IGK-MYC Fusion Oncogenic Gain-of-function 19351371, 10378696, 24957271, 7731690, 8502472, 22333947, 16934487, 21887927, 19029958, 8816814, 19246886, 22464321 +MYC PVT1-MYC Fusion Likely Oncogenic Likely Gain-of-function 22134537, 24298051 +MYC Amplification Oncogenic Gain-of-function 20164920, 10378696, 16934487, 15083194, 19029958, 22464321 +MYC Fusions Likely Oncogenic Likely Gain-of-function 22333947, 16934487 +MYC IGL-MYC Fusion Oncogenic Gain-of-function 10378696, 11034608, 7731690, 8502472, 22333947, 16934487, 19029958, 8816814, 22464321 +MYCN Amplification Oncogenic Gain-of-function 12612655, 16116477, 22035742, 22139329, 23091029, 21533284, 15013217, 9214616 +MYCN P44L Likely Oncogenic Likely Gain-of-function 23334666, 24086065 +SOX9 Deletion Likely Oncogenic Likely Loss-of-function 10446171, 12783851, 9002675 +SOX9 H65Y Likely Oncogenic Loss-of-function 10446171 +SOX9 A19V Likely Neutral Neutral 10446171 +SOX9 Truncating Mutations Likely Oncogenic Likely Loss-of-function 10446171, 27248473 +SOX9 L142P Likely Oncogenic Loss-of-function 27429045 +SOX9 P70R Likely Oncogenic Likely Loss-of-function 10446171 +SOX9 F12L Likely Oncogenic Loss-of-function 10446171 +SOX9 K398A Likely Oncogenic Gain-of-function 15694126 +TET2 W1291R Likely Oncogenic Likely Loss-of-function 24315485 +TET2 D1384V Inconclusive Inconclusive 24315485 +TET2 Y1295A Likely Neutral Likely Neutral 24315485 +TET2 R1262A Likely Neutral Likely Neutral 24315485 +TET2 Y1294A Inconclusive Inconclusive 24315485 +TET2 Y1902A Likely Oncogenic Likely Loss-of-function 24315485 +TET2 N1387A Likely Oncogenic Likely Loss-of-function 24315485 +TET2 M1293A Inconclusive Inconclusive 24315485 +TET2 Truncating Mutations Likely Oncogenic Likely Loss-of-function 21057493, 24315485 +TET2 R1896M Likely Oncogenic Likely Loss-of-function 24315485 +TET2 S1290A Likely Neutral Likely Neutral 24315485 +TET2 K1299E Inconclusive Inconclusive 24315485 +TET2 H1382Y Inconclusive Inconclusive 24315485 +TET2 Deletion Likely Oncogenic Loss-of-function 21625234, 25224413, 21723200, 22017486 +TET2 S1303N Inconclusive Inconclusive 24315485 +TET2 H1904R Likely Oncogenic Likely Loss-of-function 24315485 +MYD88 L265P Oncogenic Gain-of-function 25723115, 26111727 +MYD88 M232T Oncogenic Gain-of-function 25359991 +MYD88 S243N Oncogenic Gain-of-function 24534189, 2179087 +AGO2 R583A Likely Oncogenic Likely Loss-of-function 17891150 +AGO2 Amplification Likely Oncogenic Likely Gain-of-function 18787018, 23775134 +AGO2 A603fs Likely Oncogenic Likely Loss-of-function 20198652, 14749716 +AGO2 R647A Likely Oncogenic Likely Loss-of-function 17891150 +AGO2 Q545A Likely Oncogenic Likely Loss-of-function 17891150 +AGO2 R812A Likely Oncogenic Likely Loss-of-function 17891150 +KMT2B Truncating Mutations Inconclusive Inconclusive 25998713, 16540515, 17429066 +ATR Truncating Mutations Likely Oncogenic Likely Loss-of-function 10691732, 15282542 +ATRX Truncating Mutations Likely Oncogenic Likely Loss-of-function 21719641, 8968741, 24148618, 15591283, 14592816, 18409179, 17609377 +ATRX Deletion Likely Oncogenic Likely Loss-of-function 21719641, 27311324, 24148618, 26741321, 23904111 +CDK12 R882L Likely Oncogenic Loss-of-function 24554720, 21720365, 25712099 +CDK12 Amplification Inconclusive Inconclusive 20932292, 26658019, 21097718 +CDK12 K765R Likely Oncogenic Likely Loss-of-function 24554720, 25712099 +CDK12 Truncating Mutations Likely Oncogenic Likely Loss-of-function 24554720, 21720365, 25712099, 26787825 +CDK12 W719* Likely Oncogenic Loss-of-function 24554720, 25712099 +CDK12 L996F Likely Oncogenic Loss-of-function 24554720, 21720365, 25712099 +CDK12 Deletion Likely Oncogenic Likely Loss-of-function 24554720, 25712099, 24240700 +CDK12 Y901C Likely Oncogenic Loss-of-function 24554720, 21720365, 25712099 +CDK12 G909R Likely Oncogenic Loss-of-function 24554720, 25712099 +CDK12 D887N Likely Oncogenic Likely Loss-of-function 24554720 +CDK12 K975E Likely Neutral Likely Neutral 24554720, 21720365, 25712099 +AXL Amplification Likely Oncogenic Likely Gain-of-function 23264849, 22751098, 25337673, 25966280 +MYOD1 L122R Oncogenic Likely Gain-of-function 24793135, 1329087 +B2M M1R Likely Oncogenic Loss-of-function 22137796 +B2M M1V Likely Oncogenic Loss-of-function 24947018 +B2M M1T Likely Oncogenic Loss-of-function 22137796 +B2M Deletion Likely Oncogenic Likely Loss-of-function 25594174, 25294904, 22833104, 16730261, 22137796, 23784959, 9637706, 1898655 +B2M M1K Likely Oncogenic Loss-of-function 24947018, 22137796 +B2M M1I Likely Oncogenic Loss-of-function 11894933, 24947018 +B2M Truncating Mutations Likely Oncogenic Likely Loss-of-function 25594174, 25294904, 22833104, 16730261, 22137796, 23784959, 9637706, 1898655 +SRC Amplification Likely Oncogenic Likely Gain-of-function 24788409, 11114744, 15060621, 22589274 Zehir A et al. Nature Medicine, 2017 http://doi:10.1038/nm.4333 +SRC Q531* Likely Oncogenic Gain-of-function 9988270 +GATA3 Amplification Likely Oncogenic Likely Gain-of-function 20154722, 11441075, 18471881, 16087702, 24448324, 20855495, 21779441 +GATA3 R177Pfs*126 Likely Oncogenic Loss-of-function 26268891 +GATA3 Deletion Likely Oncogenic Likely Loss-of-function 10935639, 15361840, 23426732, 26637396, 24758297, 7829479 +GATA3 Truncating Mutations Likely Oncogenic Likely Loss-of-function 23426732, 18242514, 26637396, 27588951, 24758297 +BARD1 Truncating Mutations Likely Oncogenic Likely Loss-of-function +BARD1 Deletion Likely Oncogenic Likely Loss-of-function 20029420, 17848578, 20842729 +CCND1 256_286trunc Likely Oncogenic Gain-of-function 17299095, 9832503, 16732330, 9926916 +CCND1 C47S Likely Oncogenic Gain-of-function 24145436, 27713153 +CCND1 Y44D Likely Oncogenic Gain-of-function 24145436, 27713153 +CCND1 L283_D294del Likely Oncogenic Likely Gain-of-function 9832503, 16732330 +CCND1 T286A Oncogenic Gain-of-function 16732330, 11124803 +CCND1 D289del Oncogenic Gain-of-function 9832503, 16732330 +CCND1 P287S Likely Oncogenic Likely Gain-of-function 16732330, 12955092, 12615961 +CCND1 CCND1-IGH Fusion Likely Oncogenic Gain-of-function 14514791, 25596256, 16690963, 16402392 +CCND1 P287T Oncogenic Gain-of-function 9832503, 16732330, 12955092 +CCND1 P287A Likely Oncogenic Gain-of-function 16732330, 12615961 +CCND1 Amplification Oncogenic Gain-of-function 9832503, 20164920, 20074063, 8114739, 10508165, 11486031, 16393691, 9792703, 19020303, 21734724 +CCND1 Truncating Mutations Likely Oncogenic Likely Gain-of-function 28483394, 19823025 +CCND1 D289_D292del Likely Oncogenic Likely Gain-of-function 9832503, 16732330 +CCND1 T286I Oncogenic Gain-of-function 9832503, 16732330, 11124803 +BCL2 IGH-BCL2 Fusion Oncogenic Gain-of-function 23939148, 3500184, 18202696, 3874430, 10910891, 2875799, 23892979 +KEAP1 G480W Likely Oncogenic Likely Loss-of-function 24322982 +KEAP1 R272C Oncogenic Loss-of-function 18316592 +KEAP1 D422N Oncogenic Loss-of-function 24322982 +KEAP1 C23Y Likely Oncogenic Loss-of-function 17822677 +KEAP1 R470C Oncogenic Loss-of-function 24322982 +KEAP1 Deletion Likely Oncogenic Likely Loss-of-function 17020408, 24142871 +KEAP1 Truncating Mutations Likely Oncogenic Likely Loss-of-function 17020408, 24142871, 24322982 +KEAP1 G430C Oncogenic Loss-of-function 18316592 +KEAP1 R415G Oncogenic Loss-of-function 18316592 +KEAP1 R320Q Oncogenic Loss-of-function 24322982 +KEAP1 S243C Oncogenic Loss-of-function 24322982 +KEAP1 V155F Oncogenic Loss-of-function 24322982 +KEAP1 G333S Oncogenic Loss-of-function 23912815 +KEAP1 G423V Oncogenic Loss-of-function 24322982 +KEAP1 G333C Oncogenic Loss-of-function 19818716 +KEAP1 G186R Oncogenic Loss-of-function 24322982 +PTCH1 Truncating Mutations Likely Oncogenic Likely Loss-of-function 8782823 +PTCH1 R571W Likely Neutral Likely Neutral 24368541 +PTEN A126V Oncogenic Loss-of-function 21828076 +PTEN M199del Oncogenic Loss-of-function 11051241 +PTEN G129A Likely Oncogenic Likely Loss-of-function 21828076, 26619011 +PTEN G127N Oncogenic Loss-of-function 21828076 +PTEN G165R Likely Oncogenic Loss-of-function 10866302 +PTEN R173H Oncogenic Loss-of-function 10866302, 24721394 +PTEN G127E Oncogenic Loss-of-function 21828076 +PTEN S170R Oncogenic Loss-of-function 9467011, 10866302 +PTEN G165V Oncogenic Loss-of-function 9467011, 21828076 +PTEN H93Q Oncogenic Loss-of-function 21828076 +PTEN F154L Oncogenic Loss-of-function 19329485 +PTEN D92G Oncogenic Loss-of-function 21828076 +PTEN R130A Oncogenic Loss-of-function 21828076 +PTEN L108P Likely Oncogenic Loss-of-function 25527629 +PTEN A34D Oncogenic Loss-of-function 21828076 +PTEN A126G Oncogenic Loss-of-function 21828076 +PTEN K125E Oncogenic Loss-of-function 20926450, 21828076 +PTEN M35R Oncogenic Loss-of-function 21828076 +PTEN D162G Oncogenic Loss-of-function 21828076 +PTEN K125R Likely Neutral Neutral 21828076 +PTEN D24N Likely Oncogenic Likely Loss-of-function 17213812 +PTEN L112R Oncogenic Loss-of-function 10866302 +PTEN K125L Oncogenic Loss-of-function 21828076 +PTEN H123Q Oncogenic Loss-of-function 21828076 +PTEN I122L Oncogenic Loss-of-function 21828076 +PTEN R335L Oncogenic Loss-of-function 21828076 +PTEN C124R Oncogenic Loss-of-function 9467011, 21828076, 10866302 +PTEN R130* Oncogenic Loss-of-function 24721394 +PTEN T401I Likely Oncogenic Loss-of-function 10866302 +PTEN H93R Oncogenic Loss-of-function 21828076 +PTEN T319del Oncogenic Loss-of-function 10468583 +PTEN F341V Oncogenic Loss-of-function 11051241, 10866302 +PTEN C105F Likely Oncogenic Loss-of-function 10866302 +PTEN G251C Likely Oncogenic Loss-of-function 10866302 +PTEN S227F Likely Oncogenic Loss-of-function 10866302 +PTEN D92N Likely Oncogenic Loss-of-function 21828076 +PTEN L23F Oncogenic Loss-of-function 17213812 +PTEN R159G Likely Oncogenic Loss-of-function 17942903 +PTEN T131L Oncogenic Loss-of-function 21828076 +PTEN F347L Oncogenic Loss-of-function 10866302 +PTEN K342N Likely Oncogenic Loss-of-function 10866302 +PTEN I122V Likely Neutral Neutral 21828076 +PTEN A39P Oncogenic Loss-of-function 25527629 +PTEN G20E Likely Oncogenic Loss-of-function 17213812, 10866302 +PTEN L112P Oncogenic Loss-of-function 25527629, 10866302 +PTEN Y65C Oncogenic Loss-of-function 20926450, 19457929 +PTEN D24Y Oncogenic Loss-of-function 17213812 +PTEN L345Q Likely Oncogenic Loss-of-function 10866302 +PTEN Y27S Likely Oncogenic Loss-of-function 10866302 +PTEN A126S Oncogenic Loss-of-function 21828076 +PTEN V217D Oncogenic Loss-of-function 21828076 +PTEN R15S Oncogenic Gain-of-function 17213812 +PTEN R335* Oncogenic Loss-of-function 23475934 +PTEN R15K Oncogenic Loss-of-function 21828076 +PTEN P96Q Oncogenic Loss-of-function 21828076 +PTEN M134L Likely Oncogenic Loss-of-function 10866302 +PTEN G129R Oncogenic Loss-of-function 21828076, 25527629, 10866302, 9811831 +PTEN D92H Oncogenic Loss-of-function 21828076 +PTEN R130G Oncogenic Loss-of-function 21828076, 25527629, 11051241, 10866302, 9811831 +PTEN H93Y Oncogenic Loss-of-function 21828076, 10866302 +PTEN C124S Likely Oncogenic Loss-of-function 25527629, 9811831 +PTEN D92V Oncogenic Loss-of-function 21828076 +PTEN D162H Oncogenic Loss-of-function 23840064 +PTEN G129E Oncogenic Loss-of-function 9467011, 21828076, 25527629, 10866302, 9811831 +PTEN K62R Oncogenic Loss-of-function 20926450, 19457929 +PTEN R161G Oncogenic Loss-of-function 21828076 +PTEN T167A Oncogenic Loss-of-function 21828076 +PTEN D252G Oncogenic Loss-of-function 25527629 +PTEN A121V Likely Neutral Neutral 21828076 +PTEN A121P Likely Oncogenic Loss-of-function 10866302 +PTEN R130K Oncogenic Loss-of-function 21828076 +PTEN F241S Oncogenic Loss-of-function 21828076, 25527629 +PTEN K125M Oncogenic Loss-of-function 21828076 +PTEN H61R Likely Oncogenic Loss-of-function 10866302 +PTEN Y68H Likely Oncogenic Loss-of-function 23840064, 9467011, 10866302 +PTEN G36R Oncogenic Loss-of-function 21828076 +PTEN Y68D Oncogenic Loss-of-function 21828076 +PTEN F21A Likely Oncogenic Loss-of-function 17213812 +PTEN H123D Oncogenic Loss-of-function 21828076 +PTEN I32del Likely Oncogenic Loss-of-function 24904117, 10560660, 22817889, 9326929, 24293293 +PTEN V343L Oncogenic Loss-of-function 21828076 +PTEN S362L Likely Neutral Likely Neutral 19329485 +PTEN T131S Likely Neutral Neutral 21828076 +PTEN D331G Likely Oncogenic Loss-of-function 10866302 +PTEN E157G Oncogenic Loss-of-function 21828076 +PTEN N94I Oncogenic Loss-of-function 21828076 +PTEN V343E Oncogenic Loss-of-function 10866302 +PTEN Y155C Oncogenic Loss-of-function 21828076, 11051241, 10866302 +PTEN H61D Oncogenic Loss-of-function 21828076 +PTEN N48K Oncogenic Loss-of-function 21828076, 25527629 +PTEN V133I Likely Oncogenic Loss-of-function 10866302 +PTEN C136R Likely Oncogenic Loss-of-function 23475934 +PTEN G165E Oncogenic Loss-of-function 21828076 +PTEN Q110R Likely Neutral Likely Neutral 19329485 +PTEN R130Q Likely Oncogenic Loss-of-function 10866302 +PTEN G129D Oncogenic Loss-of-function 21828076 +PTEN A121E Oncogenic Loss-of-function 21828076 +PTEN Truncating Mutations Likely Oncogenic Likely Loss-of-function 17218262, 11237521 +PTEN S10N Likely Oncogenic Loss-of-function 10866302 +PTEN N276S Likely Oncogenic Loss-of-function 25527629 +PTEN A126D Oncogenic Loss-of-function 21828076 +PTEN I122S Oncogenic Loss-of-function 21828076 +PTEN K289E Likely Oncogenic Loss-of-function 10866302 +PTEN I168F Oncogenic Loss-of-function 21828076 +PTEN D92E Oncogenic Loss-of-function 21828076 +PTEN R173P Likely Oncogenic Loss-of-function 10866302 +PTEN T160I Oncogenic Loss-of-function 21828076 +PTEN Y174N Likely Oncogenic Loss-of-function 10866302 +PTEN I33del Likely Oncogenic Loss-of-function 24904117, 10560660, 22817889, 9326929, 24293293 +PTEN S170N Likely Oncogenic Loss-of-function 10866302 +PTEN H118P Oncogenic Loss-of-function 21828076, 25527629 +PTEN K128R Oncogenic Loss-of-function 21828076 +PTEN D107Y Likely Oncogenic Loss-of-function 10866302 +PTEN P95L Oncogenic Loss-of-function 21828076 +PTEN C136Y Oncogenic Loss-of-function 10866302 +PTEN L325F Oncogenic Loss-of-function 19329485 +PTEN G44D Oncogenic Loss-of-function 21828076 +PTEN K128N Oncogenic Loss-of-function 21828076 +PTEN K128Q Oncogenic Loss-of-function 25447541 +PTEN D92A Oncogenic Loss-of-function 21828076 +PTEN P169H Oncogenic Loss-of-function 21828076 +PTEN H123Y Oncogenic Loss-of-function 21828076 +PTEN V369G Likely Neutral Neutral 21828076, 10866302 +PTEN Y16C Likely Oncogenic Loss-of-function 10866302 +PTEN D326N Oncogenic Loss-of-function 21828076, 25527629 +PTEN T319A Likely Oncogenic Likely Loss-of-function 26166433 +PTEN R173C Likely Oncogenic Loss-of-function 10866302 +PTEN L42R Likely Oncogenic Loss-of-function 10866302 +PTEN Deletion Oncogenic Loss-of-function 12844284, 9697695, 12370746, 21430697 +PTEN C124N Oncogenic Loss-of-function 21828076 +PTEN H93D Oncogenic Loss-of-function 21828076 +PTEN K128T Oncogenic Loss-of-function 21828076 +PTEN D301N Likely Neutral Likely Neutral 19329485 +PTEN P95S Oncogenic Loss-of-function 19329485 +PTEN T131A Oncogenic Loss-of-function 21828076 +PTEN L181P Oncogenic Loss-of-function 21828076 +PTEN T131I Oncogenic Loss-of-function 21828076 +PTEN P38L Likely Oncogenic Likely Loss-of-function 23039341 +PTEN C71Y Oncogenic Loss-of-function 11051241, 10866302 +PTEN R130L Oncogenic Loss-of-function 9467011, 25527629, 10866302 +BCOR Deletion Likely Oncogenic Likely Loss-of-function 26847029, 10582652, 2212066 +BCOR BCOR-CCNB3 Fusion Oncogenic Likely Switch-of-function 22387997 +BCOR BCOR-RARA Fusion Oncogenic Likely Switch-of-function 20807888 +BCOR ZC3H7B-BCOR Fusion Oncogenic Likely Switch-of-function 23580382 +BCOR Truncating Mutations Likely Oncogenic Likely Loss-of-function 26847029, 25550361, 22237022, 22012066, 24047651 +BCOR Fusions Likely Oncogenic Likely Switch-of-function 24515802 +RNF43 Truncating Mutations Likely Oncogenic Likely Loss-of-function 23847203, 23096461, 25344691 +CIC Fusions Likely Oncogenic Likely Loss-of-function 22072439, 25007147, 28188754 +CIC R201W Likely Oncogenic Likely Loss-of-function 22072542, 25193860 +CIC R1515H Likely Oncogenic Likely Loss-of-function 22072542, 25193860 +CIC Truncating Mutations Likely Oncogenic Likely Loss-of-function 22072542, 22588899, 21817013, 24117486, 24086756 +CIC CIC-DUX4 Fusion Oncogenic Switch-of-function 22072439, 16717057 +INPP4B Deletion Likely Oncogenic Likely Loss-of-function 25883023, 25428846, 19647222, 21127264 +INPP4B Truncating Mutations Likely Oncogenic Likely Loss-of-function 25428846, 19647222, 21127264 +STAT3 F384V Likely Oncogenic Likely Gain-of-function 22751495, 17881745, 17676033, 18602572, 26619011 +STAT3 D661Y Likely Oncogenic Gain-of-function 25586472 +STAT3 F384Y Likely Oncogenic Likely Gain-of-function 22751495, 17881745, 17676033, 18602572, 26619011 +STAT3 Y640F Oncogenic Gain-of-function 25586472, 25873174, 22591296 +STAT3 F384L Likely Oncogenic Likely Gain-of-function 22751495, 17881745, 17676033, 18602572, 26619011 +STAT3 S614R Likely Oncogenic Gain-of-function 25586472, 25709890 +STAT3 D661V Likely Oncogenic Gain-of-function 22591296 +STAT3 H410R Likely Oncogenic Gain-of-function 26419508 +WHSC1L1 Amplification Inconclusive Inconclusive 18757432, 24874471, 21664949 +PRDM1 P48R Likely Oncogenic Loss-of-function 21156281 +PRDM1 C569Y Likely Oncogenic Loss-of-function 21156281 +PRDM1 Truncating Mutations Likely Oncogenic Likely Loss-of-function 20651244, 27568520, 16424392, 21156281, 16492805 +PRDM1 Y149D Likely Oncogenic Loss-of-function 21156281 +PRDM1 P48T Likely Oncogenic Loss-of-function 21156281 +PRDM1 Deletion Likely Oncogenic Likely Loss-of-function 27568520, 16424392, 21156281, 16492805 +JAK1 V658F Oncogenic Gain-of-function 20868368, 19139102, 21393331 +JAK1 A634D Oncogenic Gain-of-function 19139102 +JAK1 L783F Oncogenic Gain-of-function 21393331 +JAK1 F958S Oncogenic Gain-of-function 21393331 +JAK1 R724H Oncogenic Gain-of-function 18362171 +JAK1 S729C Oncogenic Gain-of-function 23788652 +JAK1 K1026E Oncogenic Gain-of-function 20868368 +JAK1 S703I Oncogenic Gain-of-function 24825865, 23788652 +JAK1 F958C Oncogenic Gain-of-function 21393331 +JAK1 A723D Likely Oncogenic Gain-of-function 24735922 +JAK1 Truncating Mutations Likely Oncogenic Likely Loss-of-function 24154688 +JAK1 Y1035C Oncogenic Gain-of-function 20868368 +JAK1 G871E Likely Oncogenic Likely Loss-of-function 16474838 +JAK1 Y652H Likely Oncogenic Gain-of-function 21551237 +JAK1 R879C Oncogenic Gain-of-function 18362171 +JAK1 G1079D Likely Oncogenic Gain-of-function 25873174 +JAK1 K648N Likely Oncogenic Gain-of-function 21551237 +JAK1 L910P Oncogenic Gain-of-function 20868368, 25873174, 23788652 +JAK1 F958V Oncogenic Gain-of-function 21393331 +JAK1 S646F Oncogenic Gain-of-function 19470474 +JAK2 V617F Oncogenic Gain-of-function 12351625, 15793561, 21533163, 19543316 +JAK2 R277K Inconclusive Inconclusive 26419724 +JAK2 Y931C Inconclusive Inconclusive 26419724 +JAK2 K539L Oncogenic Gain-of-function 20585391, 17267906, 21362419 +JAK2 C618R Oncogenic Gain-of-function 22960131 +JAK2 SPAG9-JAK2 Fusion Likely Oncogenic Likely Gain-of-function 25515960, 25951811 +JAK2 I1018W Inconclusive Inconclusive 26419724 +JAK2 G417P Inconclusive Inconclusive 26419724 +JAK2 TEL-JAK2 Fusion Oncogenic Gain-of-function 22733019, 10706877, 9360930, 15676212, 10845925 +JAK2 Fusions Likely Oncogenic Likely Gain-of-function 25207766, 24913195 +JAK2 S1025C Inconclusive Inconclusive 26419724 +JAK2 PAX5-JAK2 Fusion Oncogenic Gain-of-function 25207766, 25515960 +JAK2 Amplification Oncogenic Gain-of-function 20628145 +JAK2 S1039F Inconclusive Inconclusive 26419724 +JAK2 R683K Oncogenic Gain-of-function 18805579, 23748007, 23452118 +JAK2 W1038C Inconclusive Inconclusive 26419724 +JAK2 ATF7IP-JAK2 Fusion Oncogenic Gain-of-function 25207766 +JAK2 N542_E543del Oncogenic Gain-of-function 17267906 +JAK2 R683G Oncogenic Gain-of-function 18805579, 20585391, 23748007, 23452118 +JAK2 D544H Inconclusive Inconclusive 26419724 +JAK2 L1026F Inconclusive Inconclusive 26419724 +JAK2 Y1045* Inconclusive Inconclusive 26419724 +JAK2 I1018F Inconclusive Inconclusive 26419724 +JAK2 F1061W Inconclusive Inconclusive 26419724 +JAK2 F537_K539delinsL Oncogenic Gain-of-function 17267906 +JAK2 BCR-JAK2 Fusion Oncogenic Gain-of-function 25664618, 22549126, 22384256, 25789185, 23904814, 18537978, 16001431, 24913195, 18503828 +JAK2 SSBP2-JAK2 Fusion Likely Oncogenic Likely Gain-of-function 21325169, 18618714 +JAK2 L611V Likely Oncogenic Likely Gain-of-function 20182460 +JAK2 L551P Inconclusive Inconclusive 26419724 +JAK2 H538Q Oncogenic Gain-of-function 17267906 +JAK2 R683T Inconclusive Inconclusive 26419724 +JAK2 V1075F Inconclusive Inconclusive 26419724 +JAK2 R683S Oncogenic Gain-of-function 18805579, 23748007, 23452118 +JAK2 Y1045W Inconclusive Inconclusive 26419724 +JAK2 L983F Inconclusive Inconclusive 26419724 +JAK2 PCM1-JAK2 Fusion Likely Oncogenic Gain-of-function 16034466, 21325169, 23372669, 15805263, 16424865, 24913195 +JAK2 T875N Oncogenic Gain-of-function 20585391, 16804112, 19543316, 21362419 +AURKA F31I Likely Oncogenic Gain-of-function 12881723, 12208850 +AURKA K162D Likely Neutral Loss-of-function 12237287, 25395580 +AURKA Amplification Oncogenic Gain-of-function 9606188, 9771714, 10914715 +STK11 Deletion Likely Oncogenic Likely Loss-of-function 16582077, 21532627, 1627113, 19892943 +STK11 K78I Likely Oncogenic Loss-of-function 9837816 +STK11 W308C Likely Oncogenic Loss-of-function 9837816, 15987703 +STK11 Truncating Mutations Likely Oncogenic Likely Loss-of-function 24652667, 21516316, 19340305, 19892943, 25079552 +STK11 H174R Likely Oncogenic Loss-of-function 25960268 +STK11 D194Y Likely Oncogenic Loss-of-function 26917230 +STK11 F354L Likely Neutral Likely Neutral 15800014, 10676634 +STK11 G163D Likely Oncogenic Loss-of-function 9887330, 14668798, 10430928, 9605748 +STK11 R304W Oncogenic Loss-of-function 9837816, 12552571 +STK11 K78A Likely Oncogenic Loss-of-function 15800014, 14668798 +STK11 A205T Oncogenic Loss-of-function 16407837 +STK11 M136R Likely Oncogenic Loss-of-function 14668798 +STK11 D176N Likely Oncogenic Loss-of-function 9837816, 15987703 +STK11 I177N Oncogenic Loss-of-function 12552571 +STK11 L67P Likely Oncogenic Loss-of-function 9837816, 15987703 +JUN Amplification Oncogenic Gain-of-function 19449367, 17418412 +PTPN11 Q79R Likely Oncogenic Likely Gain-of-function 15834506 +PTPN11 E76K Oncogenic Gain-of-function 15834506, 12717436 +PTPN11 Y62C Likely Oncogenic Gain-of-function 15604238 +PTPN11 G464A Inconclusive Inconclusive 24935154 +PTPN11 P491S Likely Oncogenic Likely Gain-of-function 24891296 +PTPN11 D106A Oncogenic Gain-of-function 18286234 +PTPN11 E76A Oncogenic Gain-of-function 15834506, 12717436 +PTPN11 R498L Inconclusive Inconclusive 24935154 +PTPN11 K590R Likely Neutral Likely Switch-of-function 25823821 +PTPN11 A72V Oncogenic Gain-of-function 15834506 +PTPN11 R498W Likely Oncogenic Likely Loss-of-function 17053061, 24891296 +PTPN11 Deletion Oncogenic Loss-of-function 22869052 +PTPN11 Q510E Likely Oncogenic Likely Loss-of-function 25359717, 21803945, 22058153 +PTPN11 T73I Oncogenic Gain-of-function 15834506 +PTPN11 E139D Likely Oncogenic Likely Gain-of-function 16358218 +PTPN11 V45L Likely Oncogenic Gain-of-function 15604238 +PTPN11 Y63C Likely Oncogenic Gain-of-function 15834506 +PTPN11 I282V Oncogenic Gain-of-function 14974085, 15834506 +PTPN11 T507K Oncogenic Gain-of-function 15604238, 18286234 +PTPN11 E69K Likely Oncogenic Likely Gain-of-function 15604238, 12717436 +PTPN11 D61Y Oncogenic Gain-of-function 15834506, 12717436 +PTPN11 F71I Oncogenic Gain-of-function 15834506 +PTPN11 D61N Oncogenic Gain-of-function 15834506 +PTPN11 A72S Oncogenic Gain-of-function 14974085 +PTPN11 G503V Likely Oncogenic Likely Gain-of-function 15834506 +PTPN11 M504V Oncogenic Gain-of-function 15834506 +PTPN11 T468M Oncogenic Loss-of-function 26742426, 16358218, 25288766 +PTPN11 S502T Likely Oncogenic Gain-of-function 15834506 +PTPN11 N308D Oncogenic Gain-of-function 14974085, 15834506, 12717436 +NF1 R1391S Likely Oncogenic Loss-of-function 8052307, 19573811, 24576830, 9003501, 12509763, 8563751, 7542586 +NF1 Truncating Mutations Likely Oncogenic Likely Loss-of-function 8052307, 26345759, 19573811, 8563751, 23913538, 7542586, 7655472, 10862084, 24576830, 23047742, 10543400, 12509763, 14722914 +NF1 R1276Q Likely Oncogenic Loss-of-function 8052307, 19573811, 24576830, 12509763, 8563751, 22807134, 7542586 +NF1 S1463F Likely Oncogenic Loss-of-function 8052307, 19573811, 24576830, 12509763, 8563751, 22807134, 7542586, 22108604 +NF1 E1356G Likely Oncogenic Loss-of-function 8052307, 19573811, 24576830, 12509763, 8563751, 22807134, 7542586 +NF1 T1324N Likely Oncogenic Loss-of-function 8052307, 19573811, 24576830, 12509763, 8563751, 22807134, 7542586 +NF1 Deletion Likely Oncogenic Loss-of-function 23460398, 8052307, 19573811, 24576830, 12509763, 8563751, 19767589, 7542586, 20513137 +NF1 L1301R Likely Oncogenic Loss-of-function 8052307, 19573811, 24576830, 12509763, 8563751, 22807134, 7542586 +NF1 K1436Q Likely Oncogenic Loss-of-function 8052307, 19573811, 24576830, 12509763, 8563751, 22807134, 7542586 +NF1 R1276P Oncogenic Loss-of-function 9302992, 9219684, 9668168 +NF1 Y489C Oncogenic Loss-of-function 11258625 +NF1 K1423E Oncogenic Loss-of-function 8052307, 19573811, 24576830, 12509763, 8563751, 1568247, 7542586 +NF1 R2450* Likely Oncogenic Likely Loss-of-function 23288408 +NF1 V1398D Likely Oncogenic Loss-of-function 8052307, 19573811, 24576830, 12509763, 8563751, 22807134, 7542586 +NF1 R1204W Likely Oncogenic Loss-of-function 8052307, 19573811, 24576830, 12509763, 8563751, 22807134, 7542586 +NF1 R1391G Likely Oncogenic Loss-of-function 8052307, 19573811, 24576830, 12509763, 8563751, 22807134, 7542586 +NF1 R1204G Likely Oncogenic Loss-of-function 8052307, 19573811, 24576830, 12509763, 8563751, 22807134, 7542586 +FOXL2 Amplification Inconclusive Inconclusive 21623383 +FOXL2 C134W Likely Oncogenic Loss-of-function 24342437, 24817949, 23372819 +PTPRD Deletion Oncogenic Loss-of-function 19478061, 19074898, 26267899 +PTPRD G446E Likely Oncogenic Likely Loss-of-function 19074898, 25113440, 8393854 +PTPRD P1311T Likely Oncogenic Likely Loss-of-function 19478061, 26267899 +PTPRD Truncating Mutations Likely Oncogenic Likely Loss-of-function 19478061, 25113440 +PTPRD V1565I Likely Oncogenic Likely Loss-of-function 19074898 +PTPRD R1088C Likely Oncogenic Likely Loss-of-function 19478061 +BRCA1 E1682K Likely Neutral Likely Neutral 20516115 +BRCA1 C44F Likely Oncogenic Loss-of-function 20103620, 22034435, 23161852, 16403807 +BRCA1 E1282V Likely Neutral Likely Neutral 23867111 +BRCA1 S1715C Likely Oncogenic Likely Loss-of-function 20516115 +BRCA1 K56N Inconclusive Inconclusive 22034435, 16403807 +BRCA1 V1810G Likely Oncogenic Likely Loss-of-function 15004537, 15172985, 20516115 +BRCA1 R1589P Likely Neutral Likely Neutral 23867111 +BRCA1 I124V Inconclusive Inconclusive 23161852 +BRCA1 A1843T Likely Oncogenic Likely Loss-of-function 15172985, 11573086, 12496477 +BRCA1 H1746Q Inconclusive Inconclusive 23867111 +BRCA1 G1770V Likely Oncogenic Loss-of-function 23867111, 23613828 +BRCA1 I1766S Likely Oncogenic Loss-of-function 18680205, 20516115, 17308087 +BRCA1 Q1756fs Oncogenic Loss-of-function 14729053, 23867111, 27454287, 15569676, 9145676, 14576434 +BRCA1 I68K Inconclusive Inconclusive 22034435, 16403807 +BRCA1 E1250K Likely Neutral Likely Neutral 23867111 +BRCA1 W1718C Likely Oncogenic Loss-of-function 15172985, 23867111, 9799248, 20516115 +BRCA1 L1780P Likely Oncogenic Loss-of-function 15172985, 10811118, 20516115 +BRCA1 M1775R Oncogenic Loss-of-function 15004537, 14729053, 10811118, 12427738, 7545954, 8751436, 16101277, 11573086, 15689452, 15569676, 8942979, 10635334, 23161852, 15133502, 7939630, 15172985, 20516115, 21922593, 9159158 +BRCA1 G1788V Likely Oncogenic Loss-of-function 15004537, 15172985, 9796975, 15689452, 20516115 +BRCA1 L1267S Likely Neutral Likely Neutral 23867111 +BRCA1 S1651F Likely Neutral Neutral 23867111, 20516115 +BRCA1 R841Q Likely Neutral Likely Neutral 23867111 +BRCA1 S1101N Likely Neutral Likely Neutral 23867111 +BRCA1 E1836K Likely Oncogenic Likely Loss-of-function 20516115 +BRCA1 I90T Inconclusive Inconclusive 23161852 +BRCA1 F1662S Likely Neutral Likely Neutral 20516115 +BRCA1 S1164I Likely Oncogenic Likely Loss-of-function 18680205 +BRCA1 I42V Likely Neutral Neutral 20103620, 23161852 +BRCA1 A1752V Likely Oncogenic Likely Loss-of-function 20516115 +BRCA1 E33A Likely Oncogenic Likely Loss-of-function 21922593 +BRCA1 D1778Y Likely Neutral Likely Neutral 20516115 +BRCA1 P1856S Likely Neutral Likely Neutral 20516115 +BRCA1 A1830T Likely Neutral Likely Neutral 20516115 +BRCA1 C1697R Likely Oncogenic Loss-of-function 15172985, 20516115, 11157798 +BRCA1 K45T Inconclusive Inconclusive 22034435, 16403807 +BRCA1 T1720A Likely Neutral Likely Neutral 15004537, 15172985, 23867111, 15689452, 20516115 +BRCA1 N1819Y Inconclusive Inconclusive 15004537 +BRCA1 E1644G Likely Neutral Likely Neutral 17308087 +BRCA1 H1686Q Likely Oncogenic Loss-of-function 15172985, 23867111, 12496477 +BRCA1 P1637L Likely Neutral Likely Neutral 9159158 +BRCA1 F1761I Likely Oncogenic Likely Loss-of-function 15172985, 10811118 +BRCA1 P798L Likely Neutral Likely Neutral 23867111 +BRCA1 S153R Likely Neutral Neutral 23161852 +BRCA1 E143K Likely Neutral Likely Neutral 23161852 +BRCA1 W1837R Likely Oncogenic Loss-of-function 15172985, 23867111, 9799248, 8968102, 15689452, 20516115 +BRCA1 M1652K Likely Oncogenic Likely Loss-of-function 15004537, 15172985, 10811118 +BRCA1 R1699W Oncogenic Loss-of-function 15172985, 23867111, 11573086, 12496476, 20516115, 11157798, 7939630 +BRCA1 V1378I Likely Neutral Likely Neutral 23867111 +BRCA1 V1838E Likely Oncogenic Likely Loss-of-function 20516115 +BRCA1 H1421Y Likely Neutral Likely Neutral 15689452 +BRCA1 Y179C Inconclusive Inconclusive 18680205, 23161852 +BRCA1 P1806A Likely Neutral Likely Neutral 15004537, 15172985, 10811118, 20516115, 17308087 +BRCA1 P1776S Inconclusive Inconclusive 15172985, 10196379 +BRCA1 S59R Inconclusive Inconclusive 22034435, 16403807 +BRCA1 P1614S Likely Neutral Likely Neutral 17308087 +BRCA1 I89T Inconclusive Inconclusive 22034435, 16403807 +BRCA1 C39Y Oncogenic Loss-of-function 20103620, 22034435, 23161852, 21922593, 16403807 +BRCA1 L1854P Likely Oncogenic Likely Loss-of-function 20516115 +BRCA1 W1837C Likely Oncogenic Likely Loss-of-function 20516115 +BRCA1 T1773I Likely Oncogenic Likely Loss-of-function 20516115 +BRCA1 R1589H Likely Neutral Likely Neutral 23613828 +BRCA1 K45Q Likely Neutral Likely Neutral 23867111 +BRCA1 E60L Inconclusive Inconclusive 22034435, 16403807 +BRCA1 L1407P Likely Oncogenic Likely Loss-of-function 23867111, 19369211, 15689452, 16793542, 15770685 +BRCA1 S1715R Likely Oncogenic Loss-of-function 15172985, 20516115, 11157798 +BRCA1 S1841N Likely Oncogenic Likely Loss-of-function 15172985, 9799248, 20516115 +BRCA1 S1301R Likely Neutral Likely Neutral 23867111 +BRCA1 E29V Inconclusive Inconclusive 22034435, 16403807 +BRCA1 V1736G Likely Oncogenic Likely Loss-of-function 20516115 +BRCA1 I31M Likely Neutral Neutral 20103620, 23161852, 16403807 +BRCA1 T37R Likely Oncogenic Loss-of-function 20103620, 22034435, 23161852, 16403807 +BRCA1 P1856T Inconclusive Inconclusive 15172985 +BRCA1 C64G Likely Oncogenic Loss-of-function 20103620, 23867111, 22034435, 10635334, 23161852, 16403807 +BRCA1 R71G Inconclusive Inconclusive 20103620, 11385711, 23161852 +BRCA1 K50L Inconclusive Inconclusive 22034435, 16403807 +BRCA1 G1706A Likely Neutral Neutral 15172985, 23867111, 15689452, 15923272, 20516115 +BRCA1 K1702E Likely Oncogenic Likely Loss-of-function 15172985, 10811118 +BRCA1 R496C Likely Neutral Likely Neutral 18036263, 18497862 +BRCA1 S4F Inconclusive Inconclusive 23867111 +BRCA1 L246V Likely Neutral Likely Neutral 23867111 +BRCA1 K45N Inconclusive Inconclusive 22034435, 16403807 +BRCA1 C24Y Inconclusive Inconclusive 22034435, 16403807 +BRCA1 N1730S Likely Neutral Likely Neutral 15172985, 20516115 +BRCA1 Y1703S Likely Oncogenic Likely Loss-of-function 23613828 +BRCA1 R1751P Likely Oncogenic Likely Loss-of-function 15172985, 20516115 +BRCA1 V1653M Likely Oncogenic Likely Loss-of-function 15004537, 15172985, 20516115 +BRCA1 E1060A Likely Neutral Likely Neutral 23867111 +BRCA1 S308A Inconclusive Inconclusive 23867111 +BRCA1 C61G Likely Oncogenic Loss-of-function 14729053, 20103620, 23867111, 22034435, 15569676, 23161852, 16403807 +BRCA1 K1487R Likely Oncogenic Likely Loss-of-function 18992264 +BRCA1 C24R Likely Oncogenic Loss-of-function 20103620, 23161852 +BRCA1 S4P Inconclusive Inconclusive 22034435, 16403807 +BRCA1 M1783L Likely Neutral Likely Neutral 20516115 +BRCA1 V271L Likely Neutral Neutral 23867111 +BRCA1 A1823T Likely Neutral Likely Neutral 15172985, 12142080, 20516115 +BRCA1 T1691K Likely Oncogenic Likely Loss-of-function 20516115 +BRCA1 A1752G Likely Neutral Likely Neutral 23842040 +BRCA1 H1402Y Likely Neutral Likely Neutral 15689452 +BRCA1 D1778H Inconclusive Inconclusive 15172985, 9809041 +BRCA1 L165P Likely Neutral Likely Neutral 23867111 +BRCA1 V1804A Inconclusive Inconclusive 15004537 +BRCA1 W1718S Likely Oncogenic Likely Loss-of-function 15172985, 20516115 +BRCA1 R133H Likely Neutral Neutral 23161852 +BRCA1 T1773S Likely Neutral Likely Neutral 15172985, 20516115 +BRCA1 D1692H Likely Oncogenic Likely Loss-of-function 20516115 +BRCA1 D1692Y Likely Oncogenic Likely Loss-of-function 15172985, 20516115 +BRCA1 D695N Likely Neutral Likely Neutral 23867111 +BRCA1 L1657P Likely Oncogenic Likely Loss-of-function 15172985, 12496477 +BRCA1 R866C Likely Neutral Likely Neutral 23867111 +BRCA1 G57R Inconclusive Inconclusive 22034435, 16403807 +BRCA1 A1708V Likely Oncogenic Likely Loss-of-function 20516115 +BRCA1 H1805P Likely Neutral Likely Neutral 20516115 +BRCA1 N1819S Likely Neutral Likely Neutral 15172985, 20516115 +BRCA1 V191D Likely Neutral Likely Neutral 23161852 +BRCA1 G1656D Likely Oncogenic Likely Loss-of-function 20516115 +BRCA1 I89N Inconclusive Inconclusive 22034435, 16403807 +BRCA1 K50E Inconclusive Inconclusive 22034435, 16403807 +BRCA1 A1789S Likely Neutral Likely Neutral 20516115 +BRCA1 M1008I Likely Neutral Likely Neutral 23867111 +BRCA1 A1752P Likely Oncogenic Loss-of-function 15172985, 15689452, 20516115 +BRCA1 K65M Inconclusive Inconclusive 22034435, 16403807 +BRCA1 V1804D Inconclusive Inconclusive 15004537, 15172985, 23867111, 15350310, 20516115, 17308087 +BRCA1 D1778N Likely Neutral Likely Neutral 15172985, 20516115 +BRCA1 R1753T Likely Oncogenic Loss-of-function 23867111, 20516115, 17308087 +BRCA1 R1758G Inconclusive Inconclusive 15172985, 9544765 +BRCA1 L1844R Likely Neutral Likely Neutral 20516115 +BRCA1 Truncating Mutations Likely Oncogenic Likely Loss-of-function 12483515, 11358863, 20608970, 12947386 +BRCA1 V191I Likely Neutral Likely Neutral 23867111 +BRCA1 Y1703H Likely Oncogenic Likely Loss-of-function 15172985, 10811118, 11573086 +BRCA1 V1713A Oncogenic Loss-of-function 20516115, 17308087, 9159158 +BRCA1 S1613C Likely Neutral Likely Neutral 18992264 +BRCA1 M1689T Likely Oncogenic Likely Loss-of-function 20516115 +BRCA1 C47G Likely Oncogenic Loss-of-function 20103620, 22034435, 23161852, 16403807 +BRCA1 T47D Likely Neutral Likely Neutral 15569676 +BRCA1 M1663L Likely Neutral Likely Neutral 20516115 +BRCA1 S1613G Likely Neutral Likely Neutral 9159158 +BRCA1 R170W Likely Neutral Likely Neutral 23867111 +BRCA1 F1695L Likely Neutral Likely Neutral 15172985, 17161371, 20516115 +BRCA1 L63F Inconclusive Inconclusive 22034435, 16403807 +BRCA1 C44Y Oncogenic Loss-of-function 22034435, 21922593, 16403807 +BRCA1 C1767S Likely Neutral Likely Neutral 23867111 +BRCA1 T1691I Likely Oncogenic Likely Loss-of-function 23867111, 20516115 +BRCA1 F1704S Likely Oncogenic Likely Loss-of-function 15172985, 11573086, 12496477 +BRCA1 C360R Likely Neutral Likely Neutral 23867111 +BRCA1 E362H Likely Neutral Likely Neutral 23867111 +BRCA1 R170Q Likely Neutral Neutral 23161852 +BRCA1 M1411T Inconclusive Inconclusive 23867111, 19369211, 16793542, 15770685 +BRCA1 W1782C Likely Neutral Likely Neutral 23867111 +BRCA1 E1586G Likely Neutral Likely Neutral 23613828 +BRCA1 G1743R Likely Oncogenic Likely Loss-of-function 15172985, 12496477 +BRCA1 W1837G Likely Oncogenic Likely Loss-of-function 15172985, 9799248, 20516115 +BRCA1 G1706E Likely Oncogenic Loss-of-function 15172985, 23867111, 20516115, 17308087 +BRCA1 T1852S Inconclusive Inconclusive 15172985 +BRCA1 L358R Likely Neutral Likely Neutral 23867111 +BRCA1 S1448G Likely Neutral Likely Neutral 23867111 +BRCA1 G1763V Likely Oncogenic Likely Loss-of-function 20516115 +BRCA1 C39S Inconclusive Inconclusive 22034435, 16403807 +BRCA1 Q1826H Likely Neutral Likely Neutral 18992264, 20516115 +BRCA1 D1733G Likely Neutral Likely Neutral 15172985, 10811118, 17161371, 20516115, 11157798 +BRCA1 Deletion Likely Oncogenic Likely Loss-of-function 12483515, 18501021, 27452521, 12670888, 9354803 +BRCA1 L147F Likely Neutral Likely Neutral 23867111 +BRCA1 M1628V Likely Oncogenic Likely Loss-of-function 15689452 +BRCA1 M1400V Inconclusive Inconclusive 23867111, 19369211, 16793542, 15770685 +BRCA1 L82P Inconclusive Inconclusive 22034435, 16403807 +BRCA1 V1736A Likely Oncogenic Loss-of-function 15004537, 15172985, 23867111, 20516115, 17308087 +BRCA1 E1794D Likely Neutral Likely Neutral 23867111, 20516115, 17308087 +BRCA1 W1718L Likely Oncogenic Likely Loss-of-function 23613828 +BRCA1 S1715N Likely Oncogenic Loss-of-function 15172985, 20516115, 11157798 +BRCA1 M1783I Likely Neutral Likely Neutral 20516115 +BRCA1 L1564P Likely Oncogenic Likely Loss-of-function 17308087 +BRCA1 V1665M Likely Neutral Likely Neutral 15172985, 20516115, 11157798 +BRCA1 H41R Likely Oncogenic Loss-of-function 20103620, 22034435, 23161852, 16403807 +BRCA1 S1140G Likely Neutral Likely Neutral 23867111 +BRCA1 Y856H Likely Neutral Likely Neutral 23867111 +BRCA1 I26N Inconclusive Inconclusive 22034435, 16403807 +BRCA1 M1663K Likely Neutral Likely Neutral 20516115 +BRCA1 D1739E Likely Oncogenic Likely Loss-of-function 15004537, 15172985, 20516115 +BRCA1 T77M Inconclusive Inconclusive 22034435, 16403807 +BRCA1 R1699L Likely Oncogenic Likely Loss-of-function 15172985, 11573086, 20516115 +BRCA1 G1738R Likely Oncogenic Loss-of-function 15172985, 20516115, 17308087 +BRCA1 K1110del Likely Neutral Likely Neutral 23867111 +BRCA1 V1714G Likely Oncogenic Likely Loss-of-function 20516115 +BRCA1 N132K Likely Neutral Neutral 23867111, 18680205, 23161852 +BRCA1 R1751Q Likely Neutral Likely Neutral 9150149, 15172985, 20516115 +BRCA1 T826K Inconclusive Inconclusive 23867111, 10635334 +BRCA1 V1688del Likely Oncogenic Likely Loss-of-function 23867111 +BRCA1 D1818G Inconclusive Inconclusive 20516115 +BRCA1 Q1409L Likely Neutral Likely Neutral 23613828 +BRCA1 R1443G Likely Neutral Likely Neutral 23867111, 17308087 +BRCA1 P1859R Likely Neutral Likely Neutral 15172985, 20516115 +BRCA1 G1803A Likely Oncogenic Likely Loss-of-function 15172985, 20516115 +BRCA1 D1344H Inconclusive Inconclusive 25416589 +BRCA1 G1788D Likely Oncogenic Likely Loss-of-function 15172985, 20516115, 17308087 +BRCA1 C39R Inconclusive Inconclusive 22034435, 16403807 +BRCA1 R1699Q Likely Oncogenic Loss-of-function 15172985, 23867111, 11573086, 20516115, 11157798 +BRCA1 L52F Likely Neutral Neutral 20103620, 22034435, 23161852, 16403807 +BRCA1 H1862L Likely Neutral Likely Neutral 23867111 +BRCA1 D1739V Likely Oncogenic Loss-of-function 23867111, 20516115 +BRCA1 P142H Likely Neutral Neutral 23867111, 23161852 +BRCA1 Q12Y Inconclusive Inconclusive 22034435, 16403807 +BRCA1 Q1785H Likely Neutral Likely Neutral 20516115, 17308087 +BRCA1 S186Y Likely Neutral Neutral 23867111, 23161852 +BRCA1 T1685A Likely Oncogenic Likely Loss-of-function 15172985, 20516115 +BRCA1 K38N Inconclusive Inconclusive 22034435, 16403807 +BRCA1 I21V Likely Neutral Neutral 20103620, 23161852 +BRCA1 M1775V Likely Neutral Likely Neutral 15172985, 11573086, 8942979 +BRCA1 S1497A Likely Neutral Likely Neutral 23867111 +BRCA1 P1771L Likely Neutral Likely Neutral 15172985, 20516115 +BRCA1 C1787S Likely Neutral Likely Neutral 15172985, 11573086, 20516115 +BRCA1 N550H Likely Neutral Likely Neutral 18680205 +BRCA1 P1812S Inconclusive Inconclusive 15172985 +BRCA1 V1534M Likely Neutral Likely Neutral 23867111, 17308087 +BRCA1 A1708E Oncogenic Loss-of-function 15172985, 23867111, 8751436, 11573086, 15923272, 8942979, 20516115, 21922593, 11157798, 9159158, 7939630 +BRCA1 M1R Likely Oncogenic Likely Loss-of-function 21922593 +BRCA1 H1746N Likely Oncogenic Likely Loss-of-function 15172985, 20516115 +BRCA1 E1660G Likely Oncogenic Likely Loss-of-function 15172985, 12496477 +BRCA1 Y105C Likely Neutral Neutral 23867111, 23161852 +BRCA1 V1833E Likely Oncogenic Likely Loss-of-function 15172985, 10811118 +BRCA1 Q1756C Likely Oncogenic Likely Loss-of-function 8942979 +BRCA1 V1696L Likely Oncogenic Likely Loss-of-function 15172985, 20516115 +BRCA1 M1775E Likely Oncogenic Likely Loss-of-function 15172985, 11573086, 8942979 +BRCA1 D96N Inconclusive Inconclusive 22034435, 16403807 +BRCA1 D67Y Likely Neutral Neutral 20103620, 23867111, 23161852 +BRCA1 T1685I Likely Oncogenic Loss-of-function 15172985, 15689452, 20516115 +BRCA1 M18T Oncogenic Loss-of-function 20103620, 23867111, 23161852, 21922593 +BRCA1 S1655F Likely Oncogenic Loss-of-function 15004537, 23867111, 20516115, 17308087 +BRCA1 V1809F Likely Oncogenic Likely Loss-of-function 15172985, 15689452, 20516115 +BRCA1 S1651P Inconclusive Inconclusive 23867111 +BRCA1 T1700A Likely Oncogenic Loss-of-function 20516115, 17308087 +BRCA1 Y1853* Oncogenic Loss-of-function 15004537, 14729053, 8942979, 15569676, 21922593 +BRCA1 A1843P Likely Oncogenic Likely Loss-of-function 15172985, 11595708, 20516115 +BRCA1 I1807S Likely Oncogenic Likely Loss-of-function 15172985, 12496477 +BRCA1 M1775K Likely Oncogenic Loss-of-function 15172985, 18285836, 11573086, 8942979, 20516115 +BRCA1 M1689R Likely Oncogenic Likely Loss-of-function 15172985, 20516115 +BRCA1 L1664P Likely Neutral Likely Neutral 15172985, 20516115, 17308087 +BRCA1 D1692N Likely Neutral Likely Neutral 15172985, 10196379, 20516115, 11157798 +BRCA1 L28P Inconclusive Inconclusive 22034435, 16403807 +BRCA1 F1734S Likely Oncogenic Likely Loss-of-function 15172985, 20516115 +BRCA1 S72R Inconclusive Inconclusive 22034435, 16403807 +BRCA1 P1812R Likely Neutral Likely Neutral 23867111 +BRCA1 F1761S Likely Oncogenic Loss-of-function 15172985, 10811118, 20516115 +BRCA1 Y1853C Likely Oncogenic Loss-of-function 23842040, 20516115 +BRCA1 V1808A Likely Neutral Likely Neutral 15004537, 15172985, 20516115 +BRCA1 E23fs Oncogenic Loss-of-function 14729053, 23867111, 27454287, 27454289, 15569676, 9145676, 14576434 +BRCA1 H1686R Likely Oncogenic Likely Loss-of-function 23867111 +BRCA1 V1809A Likely Neutral Likely Neutral 15172985, 20516115 +BRCA1 V1833M Likely Oncogenic Likely Loss-of-function 15004537, 18992264, 15172985, 12142080, 20516115 +BRCA1 C27A Likely Oncogenic Loss-of-function 20103620, 23161852 +BRCA1 N1236K Likely Neutral Likely Neutral 23867111 +BRCA1 L1705P Likely Oncogenic Likely Loss-of-function 15172985, 10811118, 11573086 +BRCA1 M1652T Inconclusive Inconclusive 15004537, 15172985, 9585608, 20516115 +BRCA1 F79S Inconclusive Inconclusive 22034435, 16403807 +BRCA1 S1512I Likely Neutral Likely Neutral 18680205, 15689452 +BRCA1 M18K Inconclusive Inconclusive 22034435, 16403807 +BRCA1 F1734L Likely Oncogenic Likely Loss-of-function 15172985, 12496477 +BRCA1 E1214K Likely Neutral Likely Neutral 23867111 +BRCA1 S1486C Likely Neutral Likely Neutral 23867111 +BRCA1 S1473P Likely Neutral Likely Neutral 23613828 +BRCA1 R1726G Likely Neutral Likely Neutral 20516115 +BRCA1 D245V Likely Neutral Likely Neutral 23867111 +BRCA1 T231M Likely Neutral Likely Neutral 23867111 +BRCA1 A1669S Likely Neutral Likely Neutral 15172985, 20516115, 11157798 +BRCA1 N1647K Likely Neutral Likely Neutral 20516115 +BRCA1 S1841R Likely Oncogenic Likely Loss-of-function 20516115 +BRCA1 D1546N Inconclusive Inconclusive 17308087 +BRCA1 D1739G Likely Oncogenic Loss-of-function 15004537, 15172985, 23867111, 20516115 +BRCA1 V11A Inconclusive Inconclusive 18493658 +BRCA1 P1771R Likely Neutral Likely Neutral 20516115 +BRCA1 S1297del Likely Neutral Likely Neutral 23867111 +BRCA1 Q1811R Likely Oncogenic Likely Loss-of-function 15172985, 20516115 +BRCA1 L668F Likely Neutral Likely Neutral 23867111 +BRCA1 M1783T Inconclusive Inconclusive 15004537, 15172985, 20516115 +BRCA1 D1778G Likely Neutral Likely Neutral 15172985, 20516115 +BRCA1 N810Y Likely Neutral Likely Neutral 23867111 +BRCA1 P1749R Oncogenic Loss-of-function 14729053, 15172985, 8751436, 15569676, 10635334, 20516115, 21922593, 9159158 +BRCA1 V1741G Likely Oncogenic Likely Loss-of-function 12497638, 15172985, 20516115 +BRCA1 I15T Inconclusive Inconclusive 22034435, 16403807 +BRCA1 T1720I Likely Neutral Likely Neutral 15004537 +BRCA1 S1722F Likely Oncogenic Loss-of-function 15172985, 9799248, 10196379, 20516115 +BRCA1 D1739Y Likely Oncogenic Likely Loss-of-function 15172985, 20516115 +BRCA1 M1628T Likely Neutral Likely Neutral 23867111, 15350310, 15689452 +BRCA1 S988A Likely Neutral Likely Neutral 23867111 +BRCA1 M1652I Likely Neutral Likely Neutral 18992264, 15172985, 23867111, 9326340, 12215251, 9523200, 20516115, 21922593, 9159158 +BRCA1 S1841A Likely Oncogenic Likely Loss-of-function 21922593 +BRCA1 P1812A Likely Oncogenic Likely Loss-of-function 15172985, 17020472 +BRCA1 A1789T Oncogenic Loss-of-function 23867111, 18680205 +BRCA1 G1738E Likely Oncogenic Loss-of-function 15172985, 10811118, 20516115, 17308087, 11157798 +BRCA1 R1835P Likely Oncogenic Likely Loss-of-function 20516115 +BRCA1 D1851E Likely Neutral Likely Neutral 20516115 +BRCA1 L1764P Likely Oncogenic Loss-of-function 15172985, 23867111, 20516115, 17308087 +BRCA1 E1735K Inconclusive Inconclusive 15172985, 23867111, 9809041 +BRCA1 E1682V Likely Neutral Likely Neutral 20516115 +BRCA1 E1346K Likely Neutral Likely Neutral 23867111 +BRAF V600K Oncogenic Gain-of-function 16273091, 22663011, 12068308, 25265492, 24508103, 25287827, 25399551, 15035987 Planchard et al. Abstract# 8009, ASCO 2013 http://meetinglibrary.asco.org/content/112427-132 +BRAF K601Q Likely Oncogenic Gain-of-function 19206169 +BRAF D594A Likely Oncogenic Gain-of-function 14678966, 20141835, 15035987 +BRAF G469E Likely Oncogenic Likely Gain-of-function 15150094, 22510884, 15035987, 16439621 +BRAF V600_K601delinsE Oncogenic Gain-of-function 26045855, 23833300 +BRAF G478C Likely Neutral Loss-of-function 22926515 +BRAF FAM131B-BRAF Fusion Likely Oncogenic Gain-of-function 15630448, 21424530 +BRAF L597S Likely Oncogenic Likely Gain-of-function 22798288, 26643848 +BRAF G464R Likely Oncogenic Gain-of-function 15046639 +BRAF Q201H Inconclusive Inconclusive 18060073 +BRAF D594Y Likely Oncogenic Likely Gain-of-function 23833300, 20141835, 16439621 +BRAF L485_Q494del Likely Oncogenic Likely Gain-of-function 26732095 +BRAF A728V Likely Oncogenic Gain-of-function 15035987 +BRAF W531C Likely Neutral Likely Neutral 19206169 +BRAF T599I Likely Oncogenic Gain-of-function 15035987 +BRAF L485_P490delinsF Likely Oncogenic Likely Gain-of-function 26732095 +BRAF F595L Likely Oncogenic Gain-of-function 15150094, 15035987 +BRAF K601N Likely Oncogenic Gain-of-function 24270325, 26343582 +BRAF D594G Likely Oncogenic Likely Gain-of-function 23833300, 18794803, 20141835, 16439621 +BRAF L485_P490del Oncogenic Gain-of-function 26732095 +BRAF R671Q Likely Oncogenic Likely Gain-of-function 28174173 +BRAF G466R Likely Oncogenic Likely Gain-of-function 16364920, 15046639, 15035987 +BRAF D594E Likely Oncogenic Gain-of-function 20978199 Noeparast et al. Abstract# 11091, ASCO 2015 http://meeting.ascopubs.org/cgi/content/abstract/33/15_suppl/11091 +BRAF G596R Likely Oncogenic Gain-of-function 14678966, 16364920, 15035987 +BRAF T599_V600insEAT Likely Oncogenic Likely Gain-of-function 16501605 +BRAF T488_P492del Likely Oncogenic Likely Gain-of-function 26732095 +BRAF T599_V600insETT Likely Oncogenic Likely Gain-of-function 16501605 +BRAF L505H Oncogenic Gain-of-function 25515853, 24112705, 24283590 +BRAF T599insTT Oncogenic Gain-of-function 21190184 +BRAF D287H Likely Oncogenic Likely Gain-of-function 26343582 +BRAF I463S Likely Neutral Likely Neutral 15150094, 15035987 +BRAF K601E Likely Oncogenic Gain-of-function 22798288, 24583796, 24933606, 26643848, 23248257, 15035987 +BRAF D594V Likely Oncogenic Gain-of-function 14678966, 19376813, 15035987, 16439621 +BRAF K483M Likely Oncogenic Likely Gain-of-function 19376813, 23533272, 15035987, 27025703 +BRAF T599dup Oncogenic Gain-of-function 23833300, 21190184, 19363522 +BRAF G464E Likely Neutral Likely Neutral 15150094, 20141835, 15035987 +BRAF T529N Likely Neutral Likely Neutral 15573099, 20538618 +BRAF S467A Likely Oncogenic Gain-of-function 19376813, 16439621 +BRAF T599R Oncogenic Gain-of-function 25120313, 19206169 +BRAF V600M Oncogenic Gain-of-function 23463675, 16273091, 12068308, 15035987, 25382067 +BRAF L597R Likely Oncogenic Likely Gain-of-function 22798288, 26643848 +BRAF V600D_K601insFGLAT Oncogenic Gain-of-function 17297294 +BRAF S151A Likely Oncogenic Likely Gain-of-function 21478863 +BRAF N581S Likely Oncogenic Likely Gain-of-function 15035987 +BRAF R462I Likely Neutral Neutral 15150094, 15035987 +BRAF SND1-BRAF Fusion Oncogenic Gain-of-function 25266736, 25985019, 22745804, 24345920 +BRAF F468C Oncogenic Gain-of-function 15150094 +BRAF E501G Likely Neutral Likely Neutral 16474404, 16439621 +BRAF Y472C Likely Oncogenic Gain-of-function 22649091 +BRAF G469del Likely Oncogenic Likely Gain-of-function 23833300 +BRAF TRIM24-BRAF Fusion Likely Oncogenic Gain-of-function 15630448, 24345920 +BRAF p61BRAF Oncogenic Gain-of-function 22113612 +BRAF D594N Likely Oncogenic Gain-of-function 22798288 Noeparast et al. Abstract# 11091, ASCO 2015 http://meeting.ascopubs.org/cgi/content/abstract/33/15_suppl/11091 +BRAF Q257R Likely Oncogenic Gain-of-function 19376813, 16474404, 16439621 +BRAF V600D Oncogenic Gain-of-function 23317446, 20551065, 16273091, 12068308, 15035987 +BRAF A598V Likely Oncogenic Gain-of-function 19200582 +BRAF MKRN1-BRAF Fusion Likely Oncogenic Likely Gain-of-function 18974108, 26314551, 15630448, 23817572 +BRAF R506_K507insVLR Likely Oncogenic Gain-of-function 23817572 +BRAF L597Q Likely Oncogenic Gain-of-function 26343582, 22798288, 26643848 +BRAF L485F Likely Oncogenic Gain-of-function 16474404, 16439621 +BRAF G464V Oncogenic Gain-of-function 15150094, 12068308, 15035987 +BRAF KIAA1549-BRAF Fusion Oncogenic Gain-of-function 18974108, 23533272, 24345920 +BRAF V600R Oncogenic Gain-of-function 16273091, 12068308, 23473613, 15035987, 23490649 +BRAF L485_P490delinsY Likely Oncogenic Likely Gain-of-function 26732095 +BRAF AGK-BRAF Fusion Oncogenic Gain-of-function 26314551, 23890088, 24135138 +BRAF G469V Likely Oncogenic Likely Gain-of-function 25870796, 23401075 +BRAF G469R Likely Oncogenic Gain-of-function 26150740, 24920063, 16096377, 26343582, 26619011 +BRAF T529I Likely Neutral Likely Neutral 15573099, 20538618 +BRAF E275K Likely Oncogenic Likely Gain-of-function 19206169 +BRAF CUL1-BRAF Fusion Likely Oncogenic Likely Gain-of-function 25985019, 22745804, 15630448, 26324360 +BRAF Fusions Likely Oncogenic Likely Gain-of-function 18974108, 26314551, 25985019, 23890088, 22745804, 15630448, 26324360, 21424530, 24345920 +BRAF T599_V600insV Oncogenic Gain-of-function 16501605 +BRAF A598T Likely Neutral Loss-of-function 26619011, 22926515 +BRAF V600G Likely Oncogenic Gain-of-function 20735442, 16273091, 12068308, 26287849, 15035987 +BRAF G469L Likely Oncogenic Likely Gain-of-function 24920063, 24035431 +BRAF AKAP9-BRAF Fusion Oncogenic Gain-of-function 15630448 +BRAF A246P Likely Oncogenic Gain-of-function 16474404 +BRAF V487_P492delinsA Likely Oncogenic Likely Gain-of-function 26732095 +BRAF T241P Likely Oncogenic Likely Gain-of-function 19206169 +BRAF V471F Oncogenic Gain-of-function 25348715 +BRAF G596V Likely Oncogenic Likely Gain-of-function 19376813, 16439621 +BRAF PAPSS1-BRAF Fusion Likely Oncogenic Gain-of-function 15630448, 24345920 +BRAF E501K Inconclusive Inconclusive 17603482, 16474404 +BRAF N486_P490del Likely Oncogenic Likely Gain-of-function 26732095, 18060073 +BRAF G466A Likely Oncogenic Gain-of-function 17724477, 15035987 +BRAF P490_Q494del Likely Oncogenic Likely Gain-of-function 26732095 +BRAF R509H Likely Neutral Loss-of-function 20179705 +BRAF V600delinsYM Oncogenic Gain-of-function 22752848 +BRAF N581Y Likely Oncogenic Likely Gain-of-function 19474002, 26084293, 19276360, 15035987 +BRAF E586K Likely Oncogenic Gain-of-function 15035987 +BRAF L584F Inconclusive Inconclusive 23658559 +BRAF I326V Likely Neutral Likely Neutral 17603482 +BRAF N581D Likely Oncogenic Likely Gain-of-function 16474404 +BRAF K483E Likely Oncogenic Likely Gain-of-function 27799065, 23533272, 15035987 +BRAF K499E Likely Oncogenic Gain-of-function 16474404, 16439621 +BRAF R462E Likely Oncogenic Likely Gain-of-function 25155755 +BRAF G596C Likely Oncogenic Gain-of-function Noeparast et al. Abstract# 11091, ASCO 2015 http://meeting.ascopubs.org/cgi/content/abstract/33/15_suppl/11091 +BRAF Amplification Oncogenic Gain-of-function 15467732, 24055054, 25618114, 22395615, 21098728 +BRAF G469A Oncogenic Gain-of-function 23833300, 12068308, 22510884, 15035987, 22773810, 16439621 +BRAF V600E Oncogenic Gain-of-function 20179705, 16273091, 23153539, 12068308, 15035987 +BRAF T529M Likely Neutral Likely Neutral 15573099, 20538618 +BRAF L597V Oncogenic Gain-of-function 26343582, 12068308, 26643848, 15035987 +BRAF G466E Likely Oncogenic Gain-of-function 16364920, 15035987, 24446311 +BRAF G466V Likely Oncogenic Gain-of-function 22649091, 24202393, 16364920, 15035987, 16439621 +BRCA2 A2351G Inconclusive Inconclusive 18824701 +BRCA2 S2483N Inconclusive Inconclusive 18824701 +BRCA2 R2520Q Likely Neutral Likely Neutral 18451181 +BRCA2 I1349T Inconclusive Inconclusive 17924331 +BRCA2 K2729N Likely Neutral Likely Neutral 17924331, 18451181 +BRCA2 D806H Inconclusive Inconclusive 17924331 +BRCA2 T2515I Inconclusive Inconclusive 18375895 +BRCA2 K2472T Inconclusive Inconclusive 18375895 +BRCA2 A75P Inconclusive Inconclusive 17924331 +BRCA2 R2888C Inconclusive Inconclusive 17924331 +BRCA2 R2304C Inconclusive Inconclusive 18824701 +BRCA2 R3052W Likely Oncogenic Likely Loss-of-function 18451181 +BRCA2 N1102Y Inconclusive Inconclusive 17924331 +BRCA2 M784V Inconclusive Inconclusive 18824701 +BRCA2 R2418G Inconclusive Inconclusive 18824701 +BRCA2 N2113S Inconclusive Inconclusive 17924331 +BRCA2 K607T Inconclusive Inconclusive 18375895 +BRCA2 V1643A Inconclusive Inconclusive 18824701 +BRCA2 A2643G Likely Neutral Likely Neutral 18451181 +BRCA2 L929S Inconclusive Inconclusive 18824701 +BRCA2 S1670A Inconclusive Inconclusive 18375895 +BRCA2 R2659K Likely Oncogenic Loss-of-function 17924331, 18451181, 12624152 +BRCA2 R1190W Inconclusive Inconclusive 17924331 +BRCA2 T2681R Inconclusive Inconclusive 18824701 +BRCA2 E2856A Likely Neutral Likely Neutral 16489001, 18824701 +BRCA2 T2250A Inconclusive Inconclusive 17924331 +BRCA2 N372H Likely Neutral Likely Neutral 18451181 +BRCA2 S206C Likely Oncogenic Likely Loss-of-function 22962691 +BRCA2 N517S Inconclusive Inconclusive 18824701 +BRCA2 E2663V Likely Oncogenic Likely Loss-of-function 17924331, 16489001, 18451181 +BRCA2 R2318Q Inconclusive Inconclusive 16489001 +BRCA2 D3095E Likely Oncogenic Likely Loss-of-function 17924331, 18451181 +BRCA2 G1771D Inconclusive Inconclusive 17924331 +BRCA2 R2784W Likely Oncogenic Likely Loss-of-function 18451181 +BRCA2 D935N Inconclusive Inconclusive 18375895 +BRCA2 P168T Inconclusive Inconclusive 17924331 +BRCA2 P1819S Likely Neutral Likely Neutral 17924331, 18824701 +BRCA2 H1966Y Inconclusive Inconclusive 18824701 +BRCA2 L2865V Likely Neutral Likely Neutral 18451181 +BRCA2 R2502C Inconclusive Inconclusive 17924331 +BRCA2 R174C Likely Oncogenic Likely Loss-of-function 22962691 +BRCA2 N2436I Inconclusive Inconclusive 17924331 +BRCA2 R2842H Inconclusive Inconclusive 17924331 +BRCA2 K1690N Inconclusive Inconclusive 17924331 +BRCA2 F1524V Inconclusive Inconclusive 17924331 +BRCA2 L2106P Inconclusive Inconclusive 18824701 +BRCA2 H1918Y Inconclusive Inconclusive 17924331 +BRCA2 D1352Y Inconclusive Inconclusive 18824701 +BRCA2 C1265S Inconclusive Inconclusive 16489001 +BRCA2 D1280V Inconclusive Inconclusive 17924331 +BRCA2 K513R Likely Neutral Likely Neutral 17924331, 18375895 +BRCA2 Y42C Likely Neutral Likely Neutral 16489001, 18451181, 18824701, 15290653 +BRCA2 S196N Likely Oncogenic Likely Loss-of-function 22962691 +BRCA2 D3170G Inconclusive Inconclusive 17924331 +BRCA2 G173C Likely Oncogenic Likely Loss-of-function 22962691 +BRCA2 A2770T Inconclusive Inconclusive 16489001 +BRCA2 I2285V Likely Neutral Likely Neutral 17924331, 18824701 +BRCA2 V211I Likely Oncogenic Likely Loss-of-function 19179552, 23451180, 22962691 +BRCA2 G2274V Inconclusive Inconclusive 16489001 +BRCA2 L2647P Likely Oncogenic Likely Loss-of-function 18451181 +BRCA2 D191G Likely Oncogenic Likely Loss-of-function 22962691 +BRCA2 C554W Inconclusive Inconclusive 17924331 +BRCA2 R2602T Likely Oncogenic Likely Loss-of-function 18424508, 22505045 +BRCA2 A1170V Inconclusive Inconclusive 18824701 +BRCA2 T3211K Inconclusive Inconclusive 18824701 +BRCA2 D1420Y Inconclusive Inconclusive 18824701 +BRCA2 R3052Q Inconclusive Inconclusive 17924331 +BRCA2 L1904V Inconclusive Inconclusive 17924331 +BRCA2 R2842C Likely Oncogenic Likely Loss-of-function 23108138 +BRCA2 W2626C Inconclusive Inconclusive 17924331 +BRCA2 T630I Inconclusive Inconclusive 17924331 +BRCA2 G2748D Likely Oncogenic Likely Loss-of-function 17924331, 18451181 +BRCA2 N56T Inconclusive Inconclusive 17924331 +BRCA2 K1434I Inconclusive Inconclusive 18824701 +BRCA2 N588D Inconclusive Inconclusive 18824701 +BRCA2 N1878K Inconclusive Inconclusive 18824701 +BRCA2 I2627F Likely Oncogenic Likely Loss-of-function 17924331, 18451181 +BRCA2 P655R Inconclusive Inconclusive 18824701, 15290653 +BRCA2 C1365Y Inconclusive Inconclusive 17924331 +BRCA2 M2676T Inconclusive Inconclusive 18824701 +BRCA2 V3079I Inconclusive Inconclusive 17924331 +BRCA2 D2723G Likely Oncogenic Likely Loss-of-function 17924331, 18451181 +BRCA2 D2723H Likely Oncogenic Likely Loss-of-function 16489001, 18451181, 15290653 +BRCA2 V894I Inconclusive Inconclusive 17924331 +BRCA2 C3198R Inconclusive Inconclusive 17924331 +BRCA2 T2722R Inconclusive Inconclusive 17924331 +BRCA2 G602R Inconclusive Inconclusive 17924331 +BRCA2 S1172L Likely Neutral Likely Neutral 17924331, 18375895, 18824701 +BRCA2 A2717S Inconclusive Inconclusive 18375895 +BRCA2 N1228D Inconclusive Inconclusive 17924331 +BRCA2 T3349A Inconclusive Inconclusive 17924331 +BRCA2 T582P Inconclusive Inconclusive 17924331 +BRCA2 R2502H Inconclusive Inconclusive 18824701 +BRCA2 P375S Inconclusive Inconclusive 17924331 +BRCA2 Q2858R Inconclusive Inconclusive 18375895 +BRCA2 Deletion Oncogenic Loss-of-function 12483515, 18501021, 27452521, 11239455, 22193408, 16199546 +BRCA2 S326R Inconclusive Inconclusive 18824701 +BRCA2 V2969M Inconclusive Inconclusive 17924331 +BRCA2 D2723A Likely Oncogenic Likely Loss-of-function 18451181 +BRCA2 S1733F Inconclusive Inconclusive 17924331 +BRCA2 Y3098H Inconclusive Inconclusive 17924331 +BRCA2 S869L Inconclusive Inconclusive 16489001 +BRCA2 V1306I Inconclusive Inconclusive 17924331 +BRCA2 S384F Likely Neutral Likely Neutral 16489001, 18824701 +BRCA2 V2908G Likely Neutral Likely Neutral 17924331, 18451181 +BRCA2 L209F Likely Neutral Likely Neutral 22962691 +BRCA2 R2973C Likely Neutral Likely Neutral 17924331, 18451181, 18824701 +BRCA2 T1354M Inconclusive Inconclusive 17924331 +BRCA2 D2312V Inconclusive Inconclusive 17924331 +BRCA2 I1929V Inconclusive Inconclusive 17924331 +BRCA2 L2721H Inconclusive Inconclusive 18824701 +BRCA2 H2074N Inconclusive Inconclusive 17924331 +BRCA2 L2396F Inconclusive Inconclusive 17924331 +BRCA2 Y3092C Inconclusive Inconclusive 17924331 +BRCA2 Q1396R Inconclusive Inconclusive 17924331 +BRCA2 Truncating Mutations Likely Oncogenic Likely Loss-of-function 20878484, 24312913, 11239455, 22193408, 10570174 +BRCA2 S2670L Likely Neutral Likely Neutral 16489001 +BRCA2 N987I Inconclusive Inconclusive 18824701 +BRCA2 Q2384K Inconclusive Inconclusive 17924331 +BRCA2 S142I Likely Oncogenic Likely Loss-of-function 21638052 +BRCA2 E3002K Likely Oncogenic Likely Loss-of-function 21947752, 23108138, 20694749 +BRCA2 K2950N Likely Neutral Likely Neutral 17924331, 18375895 +BRCA2 L1019V Inconclusive Inconclusive 17924331 +BRCA2 R18H Inconclusive Inconclusive 18375895 +BRCA2 D2665G Likely Neutral Likely Neutral 17924331, 16489001 +BRCA2 R2336P Likely Oncogenic Likely Loss-of-function 22505045, 9150172 +BRCA2 K2411T Inconclusive Inconclusive 17924331 +BRCA2 R2659T Likely Oncogenic Likely Loss-of-function 18451181 +BRCA2 N2048I Inconclusive Inconclusive 17924331 +BRCA2 N2829R Likely Oncogenic Likely Loss-of-function 22505045 +BRCA2 N319T Likely Neutral Likely Neutral 18451181 +BRCA2 E462G Likely Neutral Likely Neutral 17924331, 18451181 +BRCA2 G1529R Inconclusive Inconclusive 17924331 +BRCA2 S1424C Inconclusive Inconclusive 18824701 +BRCA2 I2675V Likely Oncogenic Likely Loss-of-function 18424508 +BRCA2 R2108H Inconclusive Inconclusive 17924331 +BRCA2 R2336H Likely Oncogenic Loss-of-function 17924331, 18451181, 18489799 +BRCA2 G1194D Inconclusive Inconclusive 17924331 +BRCA2 L2653P Likely Oncogenic Likely Loss-of-function 17924331, 18451181 +NF2 Truncating Mutations Likely Oncogenic Likely Loss-of-function 19545378, 8755919, 22825583, 9643284 +NF2 Q324L Likely Neutral Likely Neutral 11448944 +NF2 A211D Likely Oncogenic Likely Loss-of-function 21383154, 20178741 +NF2 L535P Likely Oncogenic Likely Loss-of-function 21383154, 20178741, 10712203, 11448944 +NF2 L46R Likely Oncogenic Likely Loss-of-function 21383154, 20178741 +NF2 L64P Likely Oncogenic Likely Loss-of-function 20178741, 11448944 +NF2 T352M Likely Neutral Likely Neutral 10712203, 11448944 +NF2 K79E Likely Oncogenic Likely Loss-of-function 10712203, 11448944 +NF2 K413E Inconclusive Inconclusive 21383154, 11448944 +NF2 E106G Likely Oncogenic Likely Loss-of-function 11448944 +NF2 Q538P Likely Oncogenic Likely Loss-of-function 11448944 +NF2 Deletion Likely Oncogenic Likely Loss-of-function 24726726, 15645494, 19451229, 22825583, 9643284 +PAX8 PAX8-PPAR? Fusion Oncogenic Gain-of-function 17131411, 10958784 +NFE2L2 W24S Likely Oncogenic Gain-of-function 24142871, 18757741, 1875774 +NFE2L2 D77H Likely Oncogenic Likely Gain-of-function 16888629, 26619011 +NFE2L2 E82V Likely Oncogenic Likely Gain-of-function 12167159 +NFE2L2 E79K Likely Oncogenic Gain-of-function 24142871, 18757741, 1875774 +NFE2L2 G31R Oncogenic Gain-of-function 27147599 +NFE2L2 G31A Oncogenic Gain-of-function 27147599 +NFE2L2 D29N Likely Oncogenic Gain-of-function 24142871, 18757741, 1875774 +NFE2L2 G81S Likely Oncogenic Gain-of-function 24142871, 18757741, 1875774 +NFE2L2 I28T Likely Oncogenic Gain-of-function 24142871, 18757741, 1875774 +NFE2L2 T80A Likely Oncogenic Gain-of-function 24142871, 18757741, 1875774 +NFE2L2 E82G Likely Oncogenic Gain-of-function 23365135 +NFE2L2 D29H Likely Oncogenic Gain-of-function 24142871, 18757741, 1875774 +NFE2L2 W24C Likely Oncogenic Gain-of-function 24142871, 18757741, 1875774 +NFE2L2 G81D Likely Oncogenic Gain-of-function 24142871, 18757741, 1875774 +NFE2L2 E79Q Likely Oncogenic Gain-of-function 24142871, 18757741, 1875774 +NFE2L2 G31V Oncogenic Gain-of-function 27147599 +NFE2L2 E82D Likely Oncogenic Likely Gain-of-function 24130096, 18757741 +NFE2L2 V32G Likely Oncogenic Gain-of-function 24142871, 18757741, 1875774 +NFE2L2 T80R Likely Oncogenic Gain-of-function 24142871, 18757741, 1875774 +NFE2L2 W24R Likely Oncogenic Gain-of-function 24142871, 18757741, 1875774 +NFE2L2 T80K Oncogenic Gain-of-function 24130096, 27147599, 18757741 +NFE2L2 D29Y Likely Oncogenic Gain-of-function 24142871, 18757741, 1875774 +NFE2L2 G81R Likely Oncogenic Gain-of-function 24142871, 18757741, 1875774 +NFE2L2 L30F Likely Oncogenic Gain-of-function 24142871, 18757741, 1875774 +GLI1 R380A Likely Oncogenic Likely Loss-of-function 25476449 +GLI1 Amplification Oncogenic Gain-of-function 3563490, 1825351 +FUBP1 Truncating Mutations Likely Oncogenic Likely Loss-of-function 22072542, 22588899, 21817013, 24117486 +BTK C481S Likely Oncogenic Gain-of-function 25189416, 24869598 +BTK R544S Likely Oncogenic Likely Gain-of-function 20052711, 20826165 +BTK Y551F Likely Neutral Loss-of-function 20052711, 9188445, 20826165 +NFKBIA M37K Likely Neutral Likely Gain-of-function 23708964 +NFKBIA S36Y Likely Neutral Likely Gain-of-function 23864385 +NFKBIA E14* Likely Neutral Gain-of-function 18412279 +NFKBIA S32I Likely Neutral Gain-of-function 14523047 +GNA11 R183C Oncogenic Gain-of-function 21083380 +GNA11 Q209L Oncogenic Gain-of-function 21083380 +KDR C482R Likely Oncogenic Likely Gain-of-function 18931684, 25411163, 21712447 +KDR Q472H Likely Oncogenic Likely Gain-of-function 24793135, 24599305, 21712447 Mockus et al. Abstract# 73, AACR 2015 http://cancerres.aacrjournals.org/content/75/15_Supplement/73 +KDR Amplification Oncogenic Gain-of-function 11114740, 26578684 +KDR A1065T Likely Oncogenic Gain-of-function 19723655 +KDR D717V Oncogenic Gain-of-function 19723655 +KDR R961W Inconclusive Inconclusive 27004155 +KDR T771R Inconclusive Inconclusive 26422291, 19723655 +BCL10 Truncating Mutations Likely Oncogenic Likely Loss-of-function 10319863, 9989495 +BCL10 Deletion Likely Oncogenic Likely Loss-of-function 10319863, 9989495, 10845924 +GNAQ R183Q Likely Oncogenic Likely Gain-of-function 22236444 +GNAQ Q209L Oncogenic Gain-of-function 19078957, 1328859, 21083380 +GNAS R201H Oncogenic Gain-of-function 26257060, 24498386 +GNAS Q227R Likely Oncogenic Likely Gain-of-function 2549426 +GNAS R201C Oncogenic Gain-of-function 25288233, 20531296 +GNAS R844H Oncogenic Gain-of-function 15148396, 19423757 +GNAS Q227L Likely Oncogenic Likely Gain-of-function 2549426 +MGA Deletion Likely Oncogenic Likely Loss-of-function 10601024 +MGA Truncating Mutations Likely Oncogenic Likely Loss-of-function 23039309 +KIT W557_V560del Likely Oncogenic Likely Gain-of-function 23775962, 18955458 +KIT N822Y Likely Oncogenic Likely Gain-of-function 21689725, 18724244 +KIT Y570H Likely Oncogenic Likely Gain-of-function 21642685 +KIT A504_Y505ins Likely Oncogenic Likely Gain-of-function 16551858 +KIT Amplification Likely Oncogenic Likely Gain-of-function 15650049, 18506689, 16166280, 21523721, 19779861, 15869870, 24868028, 17189383 +KIT P577_W582delinsPYD Likely Oncogenic Likely Gain-of-function 23775962 +KIT D816E Likely Oncogenic Likely Gain-of-function 16551858, 25239608, 16397263 +KIT D52N Likely Oncogenic Likely Gain-of-function 9168438 +KIT V560G Oncogenic Gain-of-function 15790786, 16434489, 14645423, 16954519, 16397263 +KIT Exon 9 mutations Oncogenic Gain-of-function 18235121, 12181401, 23076159, 17662946, 24061512, 18955458, 16098458, 15451219 +KIT V559D Oncogenic Gain-of-function 15790786, 17372901, 18980976, 18955458, 16954519, 25605837, 15930355, 17699867, 9438854 +KIT D820Y Likely Oncogenic Likely Switch-of-function 14977822, 16551858, 18623623, 23840364, 25239608, 22614970, 18955458, 15930355, 17699867 +KIT P551_M552del Likely Oncogenic Likely Gain-of-function 18955458 +KIT K558_E562del Likely Oncogenic Likely Gain-of-function 25735500 +KIT P551_E554del Oncogenic Gain-of-function 25239608, 16954519 +KIT Exon 11 mutations Oncogenic Gain-of-function 18235121, 17372901, 25079768, 12181401, 17046465, 19282169, 25641662, 16098458, 15451219, 23177515, 19536093 +KIT K558_V559del Likely Oncogenic Likely Gain-of-function 18955458, 16954519 +KIT N505I Oncogenic Gain-of-function 24317392 +KIT W557G Likely Oncogenic Likely Gain-of-function 10224103, 25079768, 15342366 +KIT R634W Oncogenic Gain-of-function 15790786 +KIT W557_K558del Oncogenic Gain-of-function 14645423, 25239608, 16954519, 15930355, 17699867 +KIT D419del Likely Oncogenic Gain-of-function 16143141, 23599150 +KIT T417_D419delinsRG Oncogenic Gain-of-function 15790786 +KIT V569_L576del Likely Oncogenic Likely Gain-of-function 16551858, 15930355 +KIT L576P Oncogenic Gain-of-function 22357254, 17372901, 26264378, 18980976, 25605837, 15930355, 19671763, 22068222, 23775962, 21642685, 25695690, 18955458, 16954519 +KIT V559I Likely Oncogenic Gain-of-function 17259998 +KIT T670I Oncogenic Gain-of-function 16551858, 17545544, 23840364, 16954519, 17699867 +KIT N822K Oncogenic Gain-of-function 15790786, 23840364, 21482694, 24490049, 21642685, 25695690, 22614970, 16954519, 26316776, 17699867 +KIT Y553N Likely Oncogenic Likely Gain-of-function 21969494, 22357254 +KIT D820G Likely Oncogenic Likely Gain-of-function 16551858, 18623623, 23840364, 18955458, 16954519, 21456006 +KIT D816G Oncogenic Gain-of-function 25239608 +KIT K558delinsNP Oncogenic Gain-of-function 11526490, 25239608, 18955458, 16954519 +KIT T574insTQLPYD Likely Oncogenic Likely Gain-of-function 15930355 +KIT N822I Oncogenic Gain-of-function 21689725 +KIT W557R Likely Oncogenic Gain-of-function 14977822, 10224103, 19018266, 22357254, 21953054, 25079768, 21325067, 18980976, 21906875, 21642685, 20859122, 12888812 +KIT N463S Likely Oncogenic Likely Gain-of-function 21642685 +KIT C809G Likely Oncogenic Likely Gain-of-function 17139461, 18955458, 16954519 +KIT K550_K558del Oncogenic Gain-of-function 16954519, 9438854 +KIT D816F Oncogenic Gain-of-function 16397263 +KIT S501_A502dup Likely Oncogenic Gain-of-function 22324351 +KIT I653T Likely Oncogenic Likely Gain-of-function 21642685 +KIT E554_I571del Likely Oncogenic Likely Gain-of-function 16954519 +KIT V560E Likely Oncogenic Likely Gain-of-function 21690468, 22350270, 25239608 +KIT S709F Likely Oncogenic Likely Gain-of-function 16551858 +KIT P577_D579del Likely Oncogenic Likely Gain-of-function 22357254 +KIT D60N Likely Oncogenic Gain-of-function 24211109, 16226710 +KIT D572A Likely Oncogenic Gain-of-function 19865100 +KIT D816N Likely Oncogenic Gain-of-function 11369651 +KIT S476I Likely Oncogenic Gain-of-function 19865100 +KIT V559G Oncogenic Gain-of-function 23348204, 12569358 +KIT N564_Y578del Likely Oncogenic Likely Gain-of-function 16952044 +KIT T574_R588delinsL Likely Oncogenic Likely Gain-of-function 18955458 +KIT K550_W557del Oncogenic Gain-of-function 25239608 +KIT P551_V555del Oncogenic Gain-of-function 9438854 +KIT N822H Likely Oncogenic Gain-of-function 14645423, 18955458, 16954519 +KIT I563_L576del Likely Oncogenic Likely Gain-of-function 15930355 +KIT V559A Likely Oncogenic Likely Gain-of-function 15897563, 19812602, 16908931, 9438854 +KIT Y568_L576delinsVN Likely Oncogenic Likely Gain-of-function 18955458 +KIT D816A Likely Oncogenic Likely Gain-of-function 18955458, 16397263 +KIT V555_V559del Likely Oncogenic Gain-of-function 18955458, 15930355 +KIT L576del Likely Oncogenic Gain-of-function 19802003, 12717247 +KIT D820E Likely Oncogenic Likely Gain-of-function 19461405, 25886408, 15685537 +KIT K558N Likely Oncogenic Likely Gain-of-function 18980976 +KIT K550_V555delinsI Oncogenic Gain-of-function 9438854 +KIT C443Y Likely Oncogenic Gain-of-function 19865100 +KIT Y553_Q556del Likely Oncogenic Gain-of-function 15690055 +KIT D816Y Oncogenic Gain-of-function 15790786, 15167915, 16397263, 15725473 +KIT D579del Likely Oncogenic Likely Gain-of-function 24419427, 18955458 +KIT K509I Likely Oncogenic Gain-of-function 19865100 +KIT V654A Likely Oncogenic Gain-of-function 18623623, 23840364, 21642685, 18955458, 16954519, 16751810 +KIT Y418_D419del Likely Oncogenic Gain-of-function 22825855, 19603346, 16143141 +KIT V559_G565del Likely Oncogenic Likely Gain-of-function 16551858 +KIT V559C Likely Oncogenic Likely Gain-of-function 15897563, 21642685, 25695690, 9438854 +KIT A502_Y503dup Oncogenic Gain-of-function 22350270, 25239608, 18955458, 16954519, 21527588, 17699867 +KIT Q556_K558del Likely Oncogenic Likely Gain-of-function 19369884, 17372901, 25079768 +KIT V559_V560del Oncogenic Gain-of-function 16551858, 15790786, 16954519 +KIT F522C Likely Oncogenic Gain-of-function 15070706 +KIT H697Y Oncogenic Gain-of-function 19861435 +KIT D814V Oncogenic Gain-of-function 12569358 +KIT D816H Oncogenic Gain-of-function 18623623, 16956837, 18980976, 25304235, 25239608, 18955458, 16954519, 16397263 +KIT E490K Likely Oncogenic Likely Gain-of-function 22357254 +KIT E839K Likely Neutral Neutral 15790786 +KIT N655K Likely Oncogenic Likely Gain-of-function 17489795 +KIT P573_D579del Likely Oncogenic Gain-of-function 12569358, 9438854 +KIT K642E Likely Oncogenic Gain-of-function 24855380, 23940219, 11526490, 25695690, 25304235, 25239608, 14645423, 16954519 +KIT V555_L576del Likely Oncogenic Gain-of-function 23840364 +KIT V560del Oncogenic Gain-of-function 22357254, 16551858, 19861435, 15201427, 25605837 +KIT V560D Oncogenic Gain-of-function 23775962, 16551858, 23840364, 25239608, 18955458, 16954519, 25605837, 9438854 +KIT Y823D Oncogenic Gain-of-function 20633291, 22069175, 16551858, 18623623, 22301675, 18980976, 22089421, 18955458, 16954519, 15930355 +KIT E554_V559del Likely Oncogenic Likely Gain-of-function 18980976 +KIT M541L Likely Oncogenic Likely Gain-of-function 25015329, 21757432, 15790786, 20664593, 21498700, 18795925, 16307017 +KIT D820A Likely Oncogenic Likely Gain-of-function 23840364, 25239608, 18955458, 16954519 +KIT R796G Likely Neutral Loss-of-function 20824047 +KIT 550_592del Oncogenic Gain-of-function 18235121, 17372901, 25079768, 12181401, 15365079, 16098458, 15451219 +KIT V530I Oncogenic Gain-of-function 20339585, 16081693 +KIT W557_V559delinsC Likely Oncogenic Likely Gain-of-function 18955458 +KIT V559del Likely Oncogenic Gain-of-function 23993026, 15236194, 10485475, 16751810 +KIT V852I Likely Oncogenic Likely Gain-of-function 21642685 +KIT P838L Likely Oncogenic Likely Gain-of-function 21642685 +KIT Y578C Likely Oncogenic Gain-of-function 23567324 +KIT T417_D419delinsI Oncogenic Gain-of-function 15790786 +KIT D737N Inconclusive Inconclusive 26863566 +KIT P551_W557delinsL Likely Oncogenic Likely Gain-of-function 25239608 +KIT D816V Oncogenic Gain-of-function 15972446, 19193436, 7479840, 26002753, 16434489, 16397263, 15725473, 15790786, 17545544, 22301675, 16254134, 14645423, 16779792, 23659595, 23416972 +KIT M552_W557del Likely Oncogenic Likely Gain-of-function 16551858, 16954519 +KIT Y553_K558del Likely Oncogenic Likely Gain-of-function 16954519 +KIT E554_K558del Likely Oncogenic Likely Gain-of-function 18955458, 16954519, 15930355 +KIT A829P Likely Oncogenic Likely Gain-of-function 18623623, 18980976, 21642685, 25239608, 18955458 +KIT M552_K558del Likely Oncogenic Likely Gain-of-function 25239608 +KIT Exon 11 deletions Oncogenic Gain-of-function 18235121, 17372901, 25079768, 12181401, 15365079, 16098458, 15451219 +FGF19 Amplification Likely Oncogenic Likely Gain-of-function 24265351, 21397858, 22309595 +MED12 G44S Oncogenic Switch-of-function 24746821 +MED12 Exon 1 mutations Oncogenic Gain-of-function 24980722 +MED12 Deletion Likely Oncogenic Likely Loss-of-function 23178117 +MED12 L1224F Likely Oncogenic Likely Gain-of-function 12218053, 26619011, 17612495, 26383637 +MED12 Exon 2 mutations Oncogenic Likely Gain-of-function 23738515, 25038752, 23913526, 21868628 +MED12 G44D Oncogenic Switch-of-function 24746821 +NOTCH1 Deletion Likely Oncogenic Likely Gain-of-function 22077063, 23734977, 20852131 +NOTCH1 V1578del Likely Oncogenic Likely Gain-of-function 22056382, 24651013, 16618740, 25806268, 15472075, 16738328 +NOTCH1 L1574P Oncogenic Gain-of-function 22056382, 24651013, 16618740, 25806268, 15472075, 16738328 +NOTCH1 L1678P Likely Oncogenic Gain-of-function 22056382, 24651013, 16618740, 25806268, 16738328 +NOTCH1 I1718T Likely Oncogenic Gain-of-function 22056382, 24651013, 16618740, 25806268, 16738328 +NOTCH1 A1701P Likely Oncogenic Gain-of-function 22056382, 24651013, 16618740, 25806268, 16738328 +NOTCH1 P2415del Likely Oncogenic Likely Gain-of-function 24651013, 25564152, 21948802, 15472075 +NOTCH1 L1593P Likely Oncogenic Gain-of-function 22056382, 24651013, 16618740, 25806268, 16738328 +NOTCH1 MIR143-NOTCH1 Fusion Likely Oncogenic Likely Gain-of-function 23999936 +NOTCH1 Q2405Rfs*17 Likely Oncogenic Likely Gain-of-function 24651013, 25564152, 21948802, 15472075 +NOTCH1 L2429V Likely Oncogenic Likely Gain-of-function 24651013, 25564152, 21948802, 15472075 +NOTCH1 V1676D Likely Oncogenic Gain-of-function 22056382, 24651013, 16618740, 25806268, 16738328 +NOTCH1 P2417A Likely Oncogenic Likely Gain-of-function 24651013, 25564152, 21948802, 15472075 +NOTCH1 V1671I Likely Oncogenic Likely Gain-of-function 24651013, 25376516, 15472075, 19340001 +NOTCH1 R1608S Likely Neutral Likely Neutral 24651013, 16738328 +NOTCH1 L1596H Likely Oncogenic Gain-of-function 22056382, 24651013, 16618740, 25806268, 16738328 +NOTCH1 V1605del Likely Oncogenic Likely Gain-of-function 22056382, 24651013, 16618740, 25806268, 15472075, 16738328 +NOTCH1 I1680N Likely Oncogenic Gain-of-function 22056382, 24651013, 16618740, 25806268, 16738328 +NOTCH1 SEC16A1-NOTCH1 Fusion Oncogenic Gain-of-function 22101766 +NOTCH1 G2430A Likely Oncogenic Gain-of-function 20823234 +NOTCH1 Truncating Mutations in the PEST Domain Likely Oncogenic Likely Gain-of-function 22056382, 24651013, 16618740, 25564152, 21948802, 25806268, 15472075 +NOTCH1 Q2416* Likely Oncogenic Likely Gain-of-function 24651013, 25564152, 21948802, 15472075 +NOTCH1 F1592S Likely Oncogenic Gain-of-function 22056382, 24651013, 16618740, 25806268, 16738328 +NOTCH1 Truncating Mutations Upstream of Transactivation Domain Oncogenic Likely Loss-of-function 24651013, 22006338, 21798897, 21798893 +NOTCH1 V1576E Likely Oncogenic Gain-of-function 22056382, 24651013, 16618740, 25806268, 16738328 +NOTCH1 H2428Q Likely Oncogenic Likely Gain-of-function 24651013, 25564152, 21948802, 15472075 +NOTCH1 Fusions Likely Oncogenic Likely Gain-of-function 16688224, 22101766, 23033986 +NOTCH1 R1598P Likely Oncogenic Gain-of-function 22056382, 24651013, 16618740, 25806268, 16738328 +NOTCH1 L1600P Likely Oncogenic Gain-of-function 22056382, 24651013, 16618740, 25806268, 15472075, 16738328 +NOTCH1 P2412T Likely Oncogenic Likely Gain-of-function 24651013, 25564152, 21948802, 15472075 +NOTCH1 A2425T Likely Oncogenic Likely Gain-of-function 24651013, 25564152, 21948802, 15472075 +NOTCH1 I1616T Likely Oncogenic Gain-of-function 22056382, 24651013, 16618740, 25806268, 16738328 +NOTCH1 R1594Q Likely Oncogenic Loss-of-function 24651013, 22006338, 27228302 +NOTCH1 G2420C Likely Oncogenic Likely Gain-of-function 24651013, 25564152, 21948802, 15472075 +NOTCH1 I1616N Likely Oncogenic Gain-of-function 22056382, 24651013, 16618740, 25806268, 16738328 +NOTCH2 2010_2471trunc Likely Oncogenic Likely Gain-of-function 21378989 +NOTCH2 1_2009trunc Likely Oncogenic Likely Loss-of-function 22006338 +RAC1 P29S Oncogenic Gain-of-function 2546593, 22842228, 23284172, 25056119, 25465943 +RAC1 Q61R Likely Oncogenic Gain-of-function 26619011 +RAC1 C18Y Likely Oncogenic Gain-of-function 28115009 +RAC1 Amplification Likely Oncogenic Gain-of-function 24072884, 23474757 +RAC1 G12V Oncogenic Gain-of-function 23382236, 23284172 +RAC1 C157Y Likely Oncogenic Gain-of-function 23382236 +RAC1 P29L Oncogenic Gain-of-function 23382236 +DNMT3A R882C Likely Oncogenic Likely Gain-of-function 24656771, 27010239 +DNMT3A R882H Likely Oncogenic Likely Gain-of-function 22722925, 24167195, 24656771, 25416276, 27010239 +DNMT3A Truncating Mutations Likely Oncogenic Likely Loss-of-function 21067377, 25964253, 24614070 +DNMT3A Deletion Likely Oncogenic Likely Loss-of-function 21067377, 27636998 +DNMT3B DNMT3B7 Likely Oncogenic Likely Switch-of-function 20587527, 23315164, 25607950, 22815530, 17353906 +DNMT3B Amplification Likely Oncogenic Likely Gain-of-function 25470049, 22810696 +RAD21 Truncating Mutations Likely Oncogenic Likely Loss-of-function 28116354, 25006131 +RAD21 Deletion Likely Oncogenic Likely Loss-of-function 28116354, 25006131 +RAD51 Truncating Mutations Likely Oncogenic Likely Loss-of-function +RAD51C A126T Likely Neutral Neutral 21990120, 26261251, 20400964, 21980511 +RAD51C Truncating Mutations Likely Oncogenic Likely Loss-of-function 20400963, 20400964, 21616938 +RAD51C G264S Likely Neutral Neutral 21990120, 26261251, 20400964 +RAD51B HMGA2-RAD51B Fusion Likely Oncogenic Likely Switch-of-function 9892177, 26787895, 11450849 +RAD51D Truncating Mutations Likely Oncogenic Likely Loss-of-function 23372765, 21822267, 22986143 +KRAS G12C Oncogenic Gain-of-function 25705018, 24256730, 16051643, 26841430 +KRAS G12D Oncogenic Gain-of-function 17349581, 24300897, 19296721, 26037647, 11751631, 15093544, 20570890, 20147967 +KRAS A146V Likely Oncogenic Gain-of-function 3043178, 26841430 +KRAS G12V Oncogenic Gain-of-function 20516123, 20949621, 25359494, 20570890, 12957286, 20147967 +KRAS Wildtype Likely Neutral Neutral 22810696, 12506171 NCCN Colon 2.2017 https://www.nccn.org/professionals/physician_gls/pdf/colon.pdf +KRAS T74P Likely Oncogenic Gain-of-function 19075190 +KRAS G13C Oncogenic Gain-of-function 25705018, 21079152 +KRAS Q61R Oncogenic Gain-of-function 21993244, 25363767, 24651010, 25437878 +KRAS T58I Oncogenic Gain-of-function 20949621, 16474405, 18509354 +KRAS Y71H Oncogenic Gain-of-function 23059812 +KRAS Q22R Likely Oncogenic Likely Gain-of-function 20949621, 21263000 +KRAS A18D Oncogenic Gain-of-function 19490892 +KRAS G13D Oncogenic Gain-of-function 20978259, 26037647, 22722830, 20147967 +KRAS R164Q Inconclusive Inconclusive 26274561, 20147967 +KRAS P34R Oncogenic Gain-of-function 8995293, 17875937, 20949621, 16474405 +KRAS E62K Oncogenic Gain-of-function 27147599 +KRAS G60R Oncogenic Gain-of-function 20949621 +KRAS F156L Oncogenic Gain-of-function 20949621, 17601930, 7877967 +KRAS G12R Oncogenic Gain-of-function 24893629, 26037647, 21831957, 22722830 +KRAS Q61H Oncogenic Gain-of-function 25705018, 21993244, 24651010, 20147967 +KRAS K117N Oncogenic Gain-of-function 20570890, 20147967 +KRAS Y32S Likely Oncogenic Gain-of-function 11333268, 26841430 +KRAS A11_G12insGA Oncogenic Gain-of-function 24642870 +KRAS G12A Oncogenic Gain-of-function 26662311, 26037647, 25013473, 23182985 +KRAS F28L Oncogenic Gain-of-function 25600866, 20949621, 16474405 +KRAS L19F Oncogenic Gain-of-function 17150185, 20147967 +KRAS K147E Oncogenic Gain-of-function 23059812 +KRAS Y40A Inconclusive Inconclusive 11333268, 26841430 +KRAS G12S Oncogenic Gain-of-function 26184075, 25284075 +KRAS P34L Oncogenic Gain-of-function 17875937, 20949621 +KRAS V14I Oncogenic Gain-of-function 25359213, 20949621, 16474405 +KRAS Q22K Oncogenic Gain-of-function 23059812, 11095964, 20570890 +KRAS Y64A Oncogenic Gain-of-function 12628188, 26841430 +KRAS Q22E Oncogenic Gain-of-function 20949621, 21263000 +KRAS Amplification Likely Oncogenic Likely Gain-of-function 23099803, 24874471, 20841479, 23404247 +KRAS G60D Inconclusive Inconclusive 21632860 +KRAS G12F Likely Oncogenic Likely Gain-of-function 20871262 +KRAS A59G Oncogenic Gain-of-function 27147599, 1221964, 26841430 +KRAS D119N Likely Oncogenic Likely Gain-of-function 8552403, 11103938 +KRAS A146T Oncogenic Gain-of-function 19075190, 20570890, 20147967, 2403644 +KRAS E31K Likely Neutral Likely Neutral 20570890, 16483931 +KRAS Q25H Inconclusive Inconclusive 21375404 +KRAS G13E Likely Oncogenic Likely Gain-of-function 19453520, 26619011, 17503413, 19521964 +KRAS K5N Oncogenic Gain-of-function 17875937, 20949621, 25941399 +KRAS S65N Oncogenic Gain-of-function 8626650, 24798740 +KRAS Q61L Oncogenic Gain-of-function 21993244, 25363767, 24651010, 26854029, 25437878 +KRAS D153V Oncogenic Gain-of-function 17875937, 20949621, 16474405, 25941399 +KRAS G10dup Oncogenic Gain-of-function 8955068 +KRAS N116H Inconclusive Inconclusive 26841430 +NPM1 Deletion Likely Oncogenic Likely Loss-of-function 18212245, 19322210, 20877721, 16007073 +NPM1 Truncating Mutations Likely Oncogenic Likely Loss-of-function 19322210, 20877721 +RAF1 S257W Likely Oncogenic Gain-of-function 12077328, 7867061, 17603483 +RAF1 S257L Oncogenic Gain-of-function 12077328, 7867061, 24569458, 17603483 +RAF1 Fusions Likely Oncogenic Likely Gain-of-function 27810072, 19363522, 20526349, 23637631 +RAF1 I448V Oncogenic Gain-of-function 19357705 +RAF1 S259A Oncogenic Gain-of-function 24569458, 20679480 +RAF1 ESRP1-RAF1 Fusion Oncogenic Gain-of-function 20526349 +RAF1 S427G Oncogenic Gain-of-function 16585161, 19357705 +RAF1 S259F Oncogenic Gain-of-function 17603483, 20679480 +RAF1 P261L Likely Oncogenic Likely Gain-of-function 17603483, 20679480 +RAF1 Amplification Oncogenic Gain-of-function 11389083, 21215703, 16517112 Zehir A et al. Nature Medicine 2017 http://doi:10.1038/nm.4333 +RAF1 ATG7-RAF1 Fusion Likely Oncogenic Likely Gain-of-function 23637631 +RAF1 S259P Likely Oncogenic Gain-of-function 20679480 +RAF1 SRGAP3-RAF1 Fusion Oncogenic Gain-of-function 19363522 +RAB35 F161L Oncogenic Gain-of-function 26338797 +RAB35 A151T Oncogenic Gain-of-function 26338797 +HNF1A Truncating Mutations Likely Oncogenic Likely Loss-of-function 12574234, 18003757, 25793983 +HNF1A T196A Likely Neutral Neutral 21170474 +HNF1A Deletion Likely Oncogenic Likely Loss-of-function 12574234, 25793983 +HNF1A P291Qfs*51 Likely Oncogenic Likely Loss-of-function 12574234, 9313763, 16917892 +AKT3 Amplification Oncogenic Gain-of-function 17178867, 24138071, 18451171, 25737557, 15466193, 20647317 +AKT3 E17K Likely Oncogenic Gain-of-function 18813315 +AKT3 Fusions Likely Oncogenic Likely Gain-of-function 22722202 +AKT3 MAGI3-AKT3 Fusion Oncogenic Gain-of-function 22722202 +TCF3 N551K Likely Oncogenic Loss-of-function 24492847, 22885699 +TCF7L2 Truncating Mutations Likely Oncogenic Likely Loss-of-function 10919662, 16547505, 18478343, 18599616, 10485457 +RARA R276W Inconclusive Inconclusive 27148563, 23670176, 19865110, 11438209 +NRAS Q61R Oncogenic Gain-of-function 25277205, 21993244, 20194776, 23515407, 24651010, 19492075 +NRAS G12C Likely Oncogenic Likely Gain-of-function 21993244, 24651010 +NRAS Amplification Inconclusive Inconclusive 26266759, 25263998, 22876308 Zehir A et al. Nature Medicine, 2017 http://doi:10.1038/nm.4333 +NRAS G13D Oncogenic Gain-of-function 26037647, 21993244, 24651010, 22722830 +NRAS G12R Oncogenic Gain-of-function 21993244, 24651010 +NRAS Q61H Oncogenic Gain-of-function 21993244, 20194776, 23515407, 24651010 +NRAS G13V Likely Oncogenic Likely Gain-of-function 20371679, 21993244, 24651010 +NRAS Q61K Oncogenic Gain-of-function 25277205, 21993244, 20194776, 23515407, 24651010, 19492075 +NRAS Q61L Oncogenic Gain-of-function 25277205, 21993244, 20194776, 23515407, 24651010, 19492075 +NRAS T50I Likely Oncogenic Likely Gain-of-function 22817889, 19966803 +NRAS G12D Oncogenic Gain-of-function 21993244, 23687087, 24651010, 25252692, 18372904 +NRAS G12V Oncogenic Gain-of-function 18952898, 21993244, 21478863, 24651010 +NRAS G60E Likely Oncogenic Gain-of-function 19075190, 19966803, 10716188, 21263000 +NRAS T58I Likely Oncogenic Likely Gain-of-function 24265153, 16474405 +RASA1 Deletion Likely Oncogenic Likely Loss-of-function 2173144, 9121432, 9034330, 1689011 +RASA1 Y472H Likely Oncogenic Likely Loss-of-function 26993606 +RASA1 Truncating Mutations Likely Oncogenic Likely Loss-of-function 2173144, 9121432, 9034330, 1689011, 24038909 +RASA1 L481F Likely Oncogenic Likely Loss-of-function 26993606 +BCL2L11 Truncating Mutations Likely Oncogenic Likely Loss-of-function 24737648, 23382048, 26076815, 23559152, 21652541, 26001141, 23116058 +BCL2L11 Single Nucleotide Polymorphism Oncogenic Loss-of-function 24223824 +BCL2L11 Deletion Oncogenic Likely Loss-of-function 22426421, 26076815, 23559152, 23116058 +RB1 R661W Inconclusive Inconclusive 16449662, 7927327, 9420334, 1352883, 18677112 +RB1 Truncating Mutations Likely Oncogenic Likely Loss-of-function 25621664, 22293180, 22205104 +RB1 R621C Likely Oncogenic Likely Loss-of-function 20594292 +RB1 C706F Likely Oncogenic Likely Loss-of-function 18677112 +RB1 L607I Likely Oncogenic Likely Loss-of-function 20594292 +RB1 N480del Likely Neutral Likely Neutral 18677112 +RB1 R698W Likely Oncogenic Likely Loss-of-function 20594292 +RB1 Deletion Likely Oncogenic Likely Loss-of-function 16127685, 17854503, 23960888 +RB1 S567L Likely Oncogenic Likely Loss-of-function 10671068, 9420334 +RB1 C712R Likely Neutral Likely Neutral 18677112 +RB1 W563L Inconclusive Inconclusive 16269091, 10882758 +KDM5A Amplification Likely Oncogenic Likely Gain-of-function 22937203, 2293720 +NTRK1 TFG-NTRK1 Fusion Likely Oncogenic Gain-of-function 7565764, 9488046 +NTRK1 Fusions Likely Oncogenic Likely Gain-of-function 24162815 +NTRK1 NFASC-NTRK1 Fusion Oncogenic Gain-of-function 24647444 +NTRK1 TPM3-NTRK1 Fusion Oncogenic Gain-of-function 2869410, 2927393, 24962792 +NTRK1 S677N Likely Oncogenic Likely Gain-of-function 18270328 +NTRK1 BCAN-NTRK1 Fusion Likely Oncogenic Likely Gain-of-function 24647444 +NTRK1 V710A Likely Neutral Loss-of-function 27272783 +NTRK1 Delta-NTRK1 Fusion Oncogenic Gain-of-function 11073967 +NTRK1 LMNA-NTRK1 Fusion Oncogenic Gain-of-function 24445538 +NTRK1 Amplification Likely Oncogenic Gain-of-function 26496938 +NTRK1 TPR-NTRK1 Fusion Oncogenic Gain-of-function 9172002, 1532241, 7851906 +NTRK1 TRKAIII Splice Variant Oncogenic Gain-of-function 15488758 +NTRK1 MPRIP-NTRK1 Fusion Oncogenic Gain-of-function 24162815 +NTRK1 R342Q Likely Oncogenic Gain-of-function 1695324, 11313867, 23000897, 23636398, 22460905 +NTRK1 CD74-NTRK1 Fusion Oncogenic Gain-of-function 24162815 +NTRK1 CHTOP-NTRK1 Fusion Likely Oncogenic Likely Gain-of-function 24647444, 25384085 +NTRK1 R342W Likely Oncogenic Gain-of-function 1695324, 11313867, 23636398, 22460905 +NTRK2 M713I Likely Neutral Likely Loss-of-function 21242122 +NTRK2 Fusions Likely Oncogenic Likely Gain-of-function 26565381, 25204415, 26216294, 26884591, 24647444, 24445538, 26457764, 26797418, 24162815, 27843590, 26603524 +NTRK2 R734C Likely Neutral Likely Loss-of-function 21242122 +NTRK2 R715G Likely Neutral Likely Neutral 21242122 +NTRK3 Fusions Likely Oncogenic Likely Gain-of-function 26565381, 25204415, 26216294, 26884591, 27843950, 26457764, 26797418, 27148571, 26603524 +NTRK3 ETV6-NTRK3 Fusion Oncogenic Gain-of-function 10702799, 12450792 +NTRK3 G623R Likely Oncogenic Likely Gain-of-function 26884591 +NTRK3 CPEB1-NTRK3 Fusion Oncogenic Gain-of-function 24705251 +NTRK3 BTBD1-NTRK3 Fusion Oncogenic Gain-of-function 24705251 +DUSP4 Deletion Inconclusive Inconclusive 21317287, 19525976 +DDR2 Amplification Likely Oncogenic Likely Gain-of-function 24505276, 26362312, 28099935 +DDR2 L239R Oncogenic Gain-of-function 22328973, 23335507 +DDR2 L63V Oncogenic Gain-of-function 23822953, 22328973 +DDR2 G505S Likely Oncogenic Gain-of-function 23822953, 22328973 +DDR2 G774V Oncogenic Gain-of-function 22328973 +DDR2 T654I Inconclusive Inconclusive 24296828 +DDR2 G253C Oncogenic Gain-of-function 22328973, 23335507 +DDR2 T654M Inconclusive Inconclusive 22328973, 24296828 +DDR2 S768R Likely Oncogenic Likely Gain-of-function 22328973, 25173530 +DDR2 I638F Inconclusive Inconclusive 23822953, 22328973 +SOX17 Deletion Likely Oncogenic Likely Loss-of-function 17655922, 28237397, 24407731, 20716954, 17875931, 18413743, 19301122, 27738313, 21514720, 24153254, 27102016, 22846201 +SOX17 Truncating Mutations Likely Oncogenic Likely Loss-of-function +NSD1 NSD1-NUP98 Fusion Likely Oncogenic Likely Gain-of-function 11895789, 23630019 +NSD1 Fusions Likely Oncogenic Likely Gain-of-function 11895789, 23630019, 27889185 +CASP8 Truncating Mutations Likely Oncogenic Likely Loss-of-function 15531912, 19852930, 15705878, 12949717 +CASP8 G325A Likely Oncogenic Gain-of-function 23659359 +CASP8 Promoter Hypermethylation Likely Oncogenic Loss-of-function 16397500, 10969767, 11593392 +CASP8 CASP8L Likely Oncogenic Loss-of-function 12010809, 10860845, 15735742, 16374545 +CASP8 Deletion Likely Oncogenic Likely Loss-of-function 15531912, 12055196, 15705878 +CASP8 C248T Likely Neutral Neutral 12353035 +RET C618R Oncogenic Gain-of-function 9230192 +RET R833C Likely Oncogenic Likely Gain-of-function 21810974 +RET V804M Oncogenic Gain-of-function 17047083 +RET E768D Likely Oncogenic Likely Gain-of-function 10445857 +RET C634R Oncogenic Gain-of-function 9230192 +RET R886W Oncogenic Gain-of-function 21551259 +RET V804L Likely Oncogenic Likely Gain-of-function 15184865, 9242375 +RET Fusions Likely Oncogenic Likely Gain-of-function 25064355, 24561444, 22327623 +RET E632_L633del Likely Oncogenic Gain-of-function 9191060 +RET C609Y Oncogenic Gain-of-function 9230192 +RET S765P Likely Neutral Loss-of-function 11438491 +RET C634W Likely Oncogenic Likely Gain-of-function 17664273, 9230192 +RET E511K Likely Oncogenic Likely Gain-of-function 20103606, 21551259 +RET M918V Likely Oncogenic Likely Gain-of-function 21810974 +RET K603Q Likely Oncogenic Likely Gain-of-function 15277225, 11746981 +RET S904F Likely Oncogenic Likely Gain-of-function 21810974 +RET C630R Oncogenic Gain-of-function 9230192 +RET S891A Oncogenic Gain-of-function 24561444, 20554711 +RET L790F Oncogenic Gain-of-function 20444924, 15753368 +RET RET-CCDC6 Fusion Oncogenic Gain-of-function 23578175 +RET R897Q Likely Neutral Loss-of-function 11438491 +RET M918T Oncogenic Gain-of-function 8755580, 22584710, 7824936, 9681850, 24561444 +RET C634Y Likely Oncogenic Gain-of-function 9230192 +RET A919V Likely Oncogenic Likely Gain-of-function 19186126 +RET E921K Likely Neutral Loss-of-function 11438491 +RET V804G Likely Neutral Likely Loss-of-function 15184865 +RET G885R Likely Neutral Likely Neutral 25733075, 24336963 +RET M848T Likely Oncogenic Likely Gain-of-function 21810974 +RET T338I Likely Neutral Likely Neutral 21810974 +RET C634S Likely Oncogenic Gain-of-function 15277225 +RET KIF5B-RET Fusion Oncogenic Gain-of-function 22327624 +RET D631G Likely Neutral Likely Neutral 10049754 +RET I852M Likely Oncogenic Likely Gain-of-function 21711375, 11295841 +RET A919P Inconclusive Inconclusive 16928683 +RET D631A Likely Neutral Likely Neutral 10049754 +RET F893L Likely Neutral Loss-of-function 11438491 +RET Y806C Likely Oncogenic Likely Gain-of-function 19029224 +RET Y791F Likely Oncogenic Gain-of-function 15753368, 9506724, 12490841, 17209045 +RET C620R Oncogenic Gain-of-function 9230192 +RET A883F Oncogenic Gain-of-function 24561444 +RET M980T Likely Neutral Likely Neutral 11438491 +RET C611Y Oncogenic Gain-of-function 9230192 +RET V648I Likely Neutral Likely Neutral 21810974 +RET A883T Oncogenic Gain-of-function 15531548, 21810974 +RET R873Q Likely Neutral Loss-of-function 11438491 +RUNX1 Truncating Mutations Likely Oncogenic Likely Loss-of-function 15864279, 15386419, 17394134 +RUNX1 R174Q Oncogenic Loss-of-function 25490895, 21725049, 17290219 +RUNX1 R201Q Likely Oncogenic Loss-of-function 10508512 +RUNX1 RUNX1-RUNX1T1 Fusion Likely Oncogenic Loss-of-function 19414342, 21174539, 4125056, 9819404 +RUNX1 Amplification Oncogenic Gain-of-function 25592647 +RUNX1 D171G Likely Oncogenic Likely Loss-of-function 22318203 +RUNX1 H78Q Likely Oncogenic Loss-of-function 22318203 +RUNX1 D171N Oncogenic Loss-of-function 18192504, 12393679 +RUNX1 R139G Likely Oncogenic Loss-of-function 22318203 +RUNX1 R166Q Likely Oncogenic Loss-of-function 10508512 +RUNX1 R177* Oncogenic Loss-of-function 10068652, 11830488, 15156185 +RUNX1 G42R Inconclusive Inconclusive 18192504, 12874780, 12393679 +RUNX1 Y113* Oncogenic Loss-of-function 18192504 +RUNX1 S291fsX300 Oncogenic Loss-of-function 18192504 +RUNX1 K83N Likely Oncogenic Loss-of-function 11830488, 15156185 +RUNX1 K83E Likely Oncogenic Loss-of-function 11830488, 15156185 +RUNX1 R174* Oncogenic Gain-of-function 26021490, 20549580 +RUNX1 R177Q Oncogenic Loss-of-function 11830488, 18192504 +RUNX1 RUNX1-EVI1 Fusion Likely Oncogenic Loss-of-function 15156182, 19016745 +RUNX1 P173S Oncogenic Loss-of-function 18192504 +RUNX1 W279* Likely Oncogenic Likely Loss-of-function 25893166 +RUNX1 S70fsX93 Oncogenic Loss-of-function 18192504 +RUNX1 R80C Likely Oncogenic Loss-of-function 15156185 +RUNX1 Fusions Likely Oncogenic Likely Loss-of-function 21174539 +RUNX1 A122* Likely Oncogenic Likely Loss-of-function 18192504 +RUNX1 TEL-RUNX1 Fusion Likely Oncogenic Loss-of-function 15156184 diff --git a/oncocsv.csv b/oncocsv.csv new file mode 100644 index 0000000..6526b3f --- /dev/null +++ b/oncocsv.csv @@ -0,0 +1,3754 @@ +Gene,Alteration,Oncogenicity,Mutation Effect,PMIDs for Mutation Effect,Abstracts for Mutation Effect +FAM58A,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,"24218572, 18297069", +CBL,P417A,Likely Oncogenic,Loss-of-function,19387008, +CBL,M374V,Likely Neutral,Likely Neutral,26676746, +CBL,S376F,Likely Oncogenic,Loss-of-function,19387008, +CBL,Y371S,Oncogenic,Loss-of-function,19620960, +CBL,G375P,Likely Oncogenic,Loss-of-function,26676746, +CBL,C381A,Likely Oncogenic,Loss-of-function,"25178484, 26676746", +CBL,C384R,Oncogenic,Loss-of-function,23696637, +CBL,K382E,Likely Oncogenic,Loss-of-function,"25178484, 26676746", +CBL,H94Y,Inconclusive,Inconclusive,"20126411, 26676746", +CBL,R420Q,Oncogenic,Loss-of-function,"25178484, 17446348, 19387008, 19734451", +CBL,Deletion,Likely Oncogenic,Likely Loss-of-function,"19276253, 19901108, 22315494", +CBL,D390Y,Likely Oncogenic,Loss-of-function,25178484, +CBL,N454D,Likely Neutral,Neutral,19387008, +CBL,P428L,Likely Neutral,Likely Neutral,26676746, +CBL,V391I,Likely Oncogenic,Loss-of-function,26676746, +CBL,V430M,Likely Neutral,Likely Neutral,26676746, +CBL,Y371H,Oncogenic,Loss-of-function,"23696637, 26676746", +CBL,S80N,Inconclusive,Inconclusive,"20126411, 26676746", +CBL,W802*,Likely Oncogenic,Likely Gain-of-function,20126411, +CBL,P395A,Likely Oncogenic,Loss-of-function,26676746, +CBL,Q367P,Oncogenic,Loss-of-function,19620960, +CBL,C396R,Likely Oncogenic,Loss-of-function,26676746, +CBL,Q249E,Likely Oncogenic,Likely Gain-of-function,20126411, +CBL,H398Q,Likely Oncogenic,Loss-of-function,26676746, +CBL,L399V,Likely Oncogenic,Loss-of-function,26676746, +CBL,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,"20508043, 20694012, 22315494", +CBL,H398Y,Likely Oncogenic,Loss-of-function,19387008, +SHOC2,M173I,Likely Oncogenic,Loss-of-function,25137548, +SHOC2,S2G,Likely Oncogenic,Loss-of-function,"19684605, 23918763", +TERT,C228T,Oncogenic,Gain-of-function,"23348506, 23348503, 23887589, 24657534, 23530248", +TERT,Amplification,Likely Oncogenic,Likely Gain-of-function,"25219713, 18482052, 25301727", +TERT,P704S,Likely Oncogenic,Loss-of-function,18042801, +TERT,Y846C,Likely Oncogenic,Loss-of-function,18042801, +TERT,H412Y,Likely Oncogenic,Loss-of-function,18042801, +TERT,C250T,Oncogenic,Gain-of-function,"23348506, 23348503, 23887589, 26389665, 24657534, 23530248", +TERT,H876Q,Likely Oncogenic,Loss-of-function,18042801, +TERT,Promoter Mutations,Oncogenic,Gain-of-function,"23348506, 23348503, 23887589, 24657534, 25048572, 23530248", +DICER1,G1809K,Likely Oncogenic,Loss-of-function,26033159, +DICER1,D1709E,Likely Oncogenic,Likely Loss-of-function,22187960, +DICER1,Deletion,Likely Oncogenic,Likely Loss-of-function,"20305640, 26513514, 27295554, 19903759, 22353998", +DICER1,D1709N,Oncogenic,Loss-of-function,"26033159, 22187960", +DICER1,E1813A,Likely Oncogenic,Loss-of-function,17920623, +DICER1,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,"20305640, 22133720, 21501861, 22353998, 21266384", +DICER1,D1709A,Likely Oncogenic,Likely Loss-of-function,22187960, +DICER1,D1810A,Likely Oncogenic,Loss-of-function,17920623, +DICER1,E1705A,Likely Oncogenic,Loss-of-function,17920623, +DICER1,E1705K,Likely Oncogenic,Loss-of-function,22187960, +DICER1,G1809R,Oncogenic,Loss-of-function,26033159, +PALB2,T1030I,Likely Oncogenic,Likely Loss-of-function,"19737859, 19584259, 17200672, 24141787", +PALB2,L1143P,Likely Oncogenic,Likely Loss-of-function,"19737859, 19584259, 17200672, 24141787", +PALB2,L939W,Likely Oncogenic,Likely Loss-of-function,"19737859, 19584259, 17200672, 24141787", +PALB2,Y28C,Likely Oncogenic,Loss-of-function,28319063, +PALB2,L35P,Likely Oncogenic,Loss-of-function,28319063, +PALB2,K30N,Likely Neutral,Likely Neutral,28319063, +PALB2,R37H,Likely Neutral,Likely Neutral,28319063, +PALB2,K18R,Likely Neutral,Likely Neutral,28319063, +PTPRT,K218T,Likely Oncogenic,Likely Loss-of-function,18644975, +PTPRT,Y412F,Likely Oncogenic,Likely Loss-of-function,20230342, +PTPRT,Q479E,Likely Oncogenic,Likely Loss-of-function,20230342, +PTPRT,R1343L,Likely Oncogenic,Loss-of-function,15155950, +PTPRT,R1209W,Likely Oncogenic,Loss-of-function,15155950, +PTPRT,N510K,Likely Oncogenic,Likely Loss-of-function,20230342, +PTPRT,S492F,Likely Oncogenic,Likely Loss-of-function,20230342, +PTPRT,Q984K,Likely Oncogenic,Loss-of-function,"15155950, 22389709", +PTPRT,V995M,Likely Oncogenic,Loss-of-function,"24317090, 17360477", +PTPRT,T844M,Likely Oncogenic,Loss-of-function,24493670, +PTPRT,A209T,Likely Oncogenic,Likely Loss-of-function,18644975, +PTPRT,N1125I,Likely Oncogenic,Loss-of-function,"15155950, 22389709", +PTPRT,F248S,Likely Oncogenic,Likely Loss-of-function,18644975, +PTPRT,A707T,Likely Oncogenic,Likely Loss-of-function,20230342, +PTPRT,T605M,Likely Oncogenic,Likely Loss-of-function,20230342, +PTPRT,A1022E,Oncogenic,Loss-of-function,24395800, +PTPRT,T1365M,Likely Oncogenic,Loss-of-function,15155950, +PTPRT,V648G,Likely Oncogenic,Likely Loss-of-function,20230342, +PTPRT,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,"15155950, 20133777, 21517784", +PTPRT,R453C,Likely Oncogenic,Likely Loss-of-function,20230342, +PTPRT,D927G,Likely Oncogenic,Loss-of-function,22389709, +PTPRT,L708P,Likely Oncogenic,Likely Loss-of-function,20230342, +PTPRT,I395V,Likely Oncogenic,Likely Loss-of-function,20230342, +PTPRT,R1040L,Oncogenic,Likely Loss-of-function,24395800, +PTPRT,F74S,Likely Oncogenic,Likely Loss-of-function,"15155950, 18644975", +PTPRT,Promoter Hypermethylation,Oncogenic,Loss-of-function,"25009298, 25982282, 23096495", +PTPRT,Y280H,Likely Oncogenic,Likely Loss-of-function,18644975, +RHEB,Y35H,Likely Oncogenic,Gain-of-function,"24631838, 22819219", +RHEB,Y35C,Oncogenic,Gain-of-function,"24631838, 22819219", +RHEB,Y35N,Oncogenic,Gain-of-function,"24631838, 27399332, 22819219, 26255626", +SHQ1,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,"19383767, 20579941, 12228251", +SHQ1,Deletion,Likely Oncogenic,Likely Loss-of-function,"19383767, 19019820, 20579941", +CCND2,Amplification,Likely Oncogenic,Likely Gain-of-function,8114739, +RAD50,L1273F,Likely Oncogenic,Loss-of-function,24934408, +RAD50,L234fs,Likely Oncogenic,Likely Loss-of-function,"16474176, 14684699, 16385572", +RAD50,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,"12208847, 16288216, 21892167, 14684699", +RAD50,Deletion,Likely Oncogenic,Likely Loss-of-function,"12208847, 2659437, 14684699, 15309560", +CCND3,D286_L292trunc,Likely Oncogenic,Likely Gain-of-function,9832503, +CCND3,Amplification,Likely Oncogenic,Likely Gain-of-function,8114739, +CCND3,Q276*,Likely Oncogenic,Gain-of-function,"2876518, 24913233, 22885699", +CCND3,I290A,Likely Oncogenic,Likely Gain-of-function,9832503, +CCND3,T283A,Likely Oncogenic,Gain-of-function,"2876518, 24913233, 22885699", +CCND3,I290R,Likely Oncogenic,Likely Gain-of-function,"2876518, 24913233, 22885699", +CCND3,P284L,Likely Oncogenic,Likely Gain-of-function,"2876518, 24913233, 22885699", +CCND3,T286A,Likely Oncogenic,Gain-of-function,9832503, +RIT1,R122L,Oncogenic,Gain-of-function,24469055, +RIT1,M90I,Oncogenic,Gain-of-function,24469055, +RIT1,Q40L,Likely Neutral,Neutral,24469055, +RIT1,T76insTLDT,Oncogenic,Gain-of-function,24469055, +RIT1,Q79L,Oncogenic,Gain-of-function,24469055, +RIT1,A77P,Oncogenic,Gain-of-function,24469055, +RIT1,A77T,Likely Oncogenic,Likely Gain-of-function,26714497, +RIT1,F82L,Oncogenic,Gain-of-function,24469055, +RIT1,A77S,Oncogenic,Gain-of-function,24469055, +RIT1,TA83del,Oncogenic,Gain-of-function,24469055, +CCNE1,Overexpression,Oncogenic,Gain-of-function,"8618861, 15838514, 12845634, 24605326", +CCNE1,Amplification,Oncogenic,Gain-of-function,"8618861, 15838514, 12845634, 24605326", +RYBP,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,19098711, +TGFBR1,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,"10656986, 11212236", +TGFBR1,R487Q,Likely Oncogenic,Likely Loss-of-function,"16928994, 25116393, 16791849", +TGFBR1,P83L,Likely Oncogenic,Loss-of-function,21358634, +TGFBR1,C41Y,Likely Oncogenic,Loss-of-function,21358634, +TGFBR1,G52R,Likely Oncogenic,Loss-of-function,"21358634, 23358096", +TGFBR1,S387Y,Likely Oncogenic,Loss-of-function,9809982, +TGFBR1,S241L,Likely Oncogenic,Likely Loss-of-function,16791849, +TGFBR1,N45S,Likely Oncogenic,Loss-of-function,"21358634, 23358096", +TGFBR1,TGFBR1*6A,Likely Oncogenic,Loss-of-function,"17848956, 10582683, 20429896, 16204663, 19882361, 22905183", +TGFBR2,E526Q,Likely Oncogenic,Loss-of-function,"18339844, 10789724", +TGFBR2,R537P,Likely Oncogenic,Likely Gain-of-function,18339844, +TGFBR2,Deletion,Likely Oncogenic,Likely Loss-of-function,"27558455, 25521327, 25736321", +TGFBR2,D404G,Likely Oncogenic,Loss-of-function,8668164, +TGFBR2,P525L,Likely Oncogenic,Loss-of-function,7862150, +TGFBR2,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,"16310402, 17456004, 17985359, 9927040, 11309634, 7585632", +MSH6,T1219I,Likely Oncogenic,Likely Loss-of-function,"11709755, 24362816, 22102614, 23621914", +MSH6,R1095H,Likely Neutral,Likely Neutral,"22581703, 24040339, 12522549, 23621914", +MSH6,R976H,Likely Oncogenic,Likely Loss-of-function,"11709755, 24362816, 11807791, 18790734", +MSH6,F1088*fs,Likely Neutral,Likely Loss-of-function,"21674763, 15837969", +MSH6,R1076C,Likely Oncogenic,Likely Loss-of-function,"21056691, 19072991", +MSH6,G39E,Likely Neutral,Likely Neutral,24362816, +MSH6,V509A,Likely Neutral,Likely Neutral,24362816, +MSH6,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,"24755471, 9822680, 24362816, 9111312, 22810696, 1651234, 9564049", +MSH6,Deletion,Likely Oncogenic,Likely Loss-of-function,"25255306, 24090359, 21970482, 12019211, 22781090", +MSH6,S144I,Likely Neutral,Likely Neutral,21120944, +KMT2D,Deletion,Likely Oncogenic,Likely Loss-of-function,"24633898, 24240169, 26366712", +KMT2D,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,"24633898, 24240169, 26366712", +LATS1,Truncating Mutations,Likely Oncogenic,Loss-of-function,"9988269, 23230145, 11850843", +LATS1,Deletion,Likely Oncogenic,Likely Loss-of-function,"9988269, 23573293, 26040669", +PBRM1,N1333Gfs*,Oncogenic,Loss-of-function,25911086, +PBRM1,Deletion,Likely Oncogenic,Likely Loss-of-function,"18339845, 21248752, 23867514, 22949125", +PBRM1,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,"18339845, 24613357, 21248752, 22949125, 21654818", +SF3B1,E622Q,Likely Oncogenic,Switch-of-function,"26565915, 25428262, 21909114", +SF3B1,R625H,Likely Oncogenic,Switch-of-function,"24434863, 26565915, 23861464", +SF3B1,R625G,Likely Oncogenic,Switch-of-function,"25788694, 26565915", +SF3B1,K666N,Likely Oncogenic,Switch-of-function,"24434863, 25788694", +SF3B1,K700E,Likely Oncogenic,Switch-of-function,"25424858, 24434863, 26565915, 24854990, 23335386, 25428262, 23160465, 27622333, 21909114", +SF3B1,K700R,Likely Oncogenic,Likely Switch-of-function,"24434863, 26565915, 26619011, 25428262", +SF3B1,R625D,Likely Oncogenic,Switch-of-function,24434863, +SF3B1,H662D,Likely Oncogenic,Switch-of-function,25428262, +SF3B1,R957Q,Likely Oncogenic,Switch-of-function,23160465, +SF3B1,K666R,Oncogenic,Switch-of-function,"25428262, 21909114", +SF3B1,H662R,Likely Oncogenic,Switch-of-function,"25428262, 21909114", +SF3B1,R625L,Likely Oncogenic,Switch-of-function,"24434863, 26565915, 23861464", +SF3B1,K666T,Likely Oncogenic,Switch-of-function,"24434863, 26842708", +SF3B1,K666M,Likely Oncogenic,Switch-of-function,24434863, +SF3B1,R625C,Likely Oncogenic,Switch-of-function,"24434863, 26565915, 23861464", +SF3B1,G742D,Likely Oncogenic,Switch-of-function,"24434863, 25428262, 21909114", +SF3B1,E622D,Likely Oncogenic,Switch-of-function,"25428262, 21909114", +SF3B1,H662Q,Likely Oncogenic,Switch-of-function,"25428262, 21909114", +LATS2,Deletion,Oncogenic,Loss-of-function,21245096, +EGFR,E746_S752delinsA,Oncogenic,Gain-of-function,"15118073, 15329413, 15710947, 15118125", +EGFR,E866K,Likely Neutral,Loss-of-function,19147750, +EGFR,E746_T751delinsL,Oncogenic,Gain-of-function,"15118073, 15329413, 18261621, 15118125", +EGFR,L858R,Oncogenic,Gain-of-function,"15118073, 15329413, 15118125", +EGFR,G719D,Likely Oncogenic,Likely Gain-of-function,"21531810, 18000506, 26206867", +EGFR,I744_K745delinsKIPVAI,Oncogenic,Gain-of-function,"15118073, 15329413, 21841502, 15118125", +EGFR,D761N,Likely Oncogenic,Gain-of-function,"19147750, 26870223", +EGFR,V726M,Likely Oncogenic,Likely Gain-of-function,18000506, +EGFR,S921R,Likely Neutral,Inconclusive,19020901, +EGFR,R776H,Likely Oncogenic,Gain-of-function,"23242437, 20512075, 23358982", +EGFR,A767_V769del,Likely Oncogenic,Likely Gain-of-function,"23371856, 19536777, 24353160, 21764376, 18676761, 15897572, 17686547", +EGFR,A864T,Oncogenic,Gain-of-function,"23585556, 19147750, 21761100, 22722798, 16551849", +EGFR,A750P,Oncogenic,Gain-of-function,"19625781, 25179728, 15737014, 16187797", +EGFR,G863D,Likely Oncogenic,Gain-of-function,"17376509, 16204011, 15897572", +EGFR,A750_E758delinsP,Oncogenic,Gain-of-function,"15118073, 15329413, 18261621, 15118125", +EGFR,E709Q,Likely Oncogenic,Likely Gain-of-function,"19671738, 15897572", +EGFR,S768I,Oncogenic,Gain-of-function,"19536777, 16205628, 25521406, 25521405, 23242437, 19147750, 18676761, 23912954, 25179728, 25130612", +EGFR,D837N,Likely Oncogenic,Likely Gain-of-function,23749122, +EGFR,D770_N771insNPG,Oncogenic,Gain-of-function,"23371856, 19536777, 24353160, 21764376, 18676761, 15897572, 17686547", +EGFR,H773L,Oncogenic,Gain-of-function,17974985, +EGFR,E709_T710delinsD,Oncogenic,Gain-of-function,"21531810, 26206867", +EGFR,T1041A,Likely Oncogenic,Likely Gain-of-function,24797263, +EGFR,W731L,Likely Oncogenic,Gain-of-function,20942962, +EGFR,L747P,Oncogenic,Gain-of-function,"21531810, 18508816, 19536777, 26339441, 26001153, 22190593", +EGFR,EGFR-PURB Fusion,Likely Oncogenic,Likely Gain-of-function,27102076, +EGFR,V774A,Likely Oncogenic,Likely Gain-of-function,21531810, +EGFR,L861F,Likely Oncogenic,Likely Gain-of-function,"21531810, 19536777, 19147750, 17177598, 26051236, 21252719", +EGFR,S768_V769insVAS,Oncogenic,Gain-of-function,"23371856, 19536777, 24353160, 21764376, 18676761, 15897572, 21841502, 17686547", +EGFR,G863S,Likely Oncogenic,Likely Gain-of-function,18000506, +EGFR,T725M,Likely Oncogenic,Gain-of-function,24743239, +EGFR,H773dup,Oncogenic,Gain-of-function,24353160, +EGFR,L861R,Oncogenic,Gain-of-function,"21531810, 17177598, 24743239, 21841502, 21252719", +EGFR,G719S,Oncogenic,Gain-of-function,"21531810, 16187797, 26206867", +EGFR,E758G,Likely Oncogenic,Likely Gain-of-function,19536777, +EGFR,G465R,Likely Oncogenic,Likely Gain-of-function,26416732, +EGFR,T783A,Likely Oncogenic,Likely Gain-of-function,"18676761, 15897572", +EGFR,L704N,Likely Neutral,Loss-of-function,24063894, +EGFR,E868G,Likely Oncogenic,Gain-of-function,"20942962, 16870303", +EGFR,L858Q,Likely Oncogenic,Likely Gain-of-function,24743239, +EGFR,S492R,Likely Oncogenic,Likely Switch-of-function,22270724, +EGFR,E746Q,Likely Oncogenic,Likely Gain-of-function,16467085, +EGFR,D761Y,Likely Oncogenic,Likely Gain-of-function,"17973572, 17545553, 19632948, 17085664, 17192902", +EGFR,E746_A750delinsQ,Oncogenic,Gain-of-function,"15118073, 15329413, 15118125, 17192902", +EGFR,G719A,Oncogenic,Gain-of-function,"21531810, 26206867", +EGFR,H773_V774insH,Oncogenic,Gain-of-function,24353160, +EGFR,V851A,Likely Neutral,Loss-of-function,19147750, +EGFR,L747_E749del,Oncogenic,Gain-of-function,"16467085, 15118073, 15329413, 25179728, 15118125", +EGFR,E746_T751delinsVA,Oncogenic,Gain-of-function,"18508816, 15118073, 15329413, 15897572, 15118125", +EGFR,D770_N771insVDSVDNP,Oncogenic,Gain-of-function,"23371856, 19536777, 24353160, 21764376, 18676761, 15897572, 21841502, 17686547", +EGFR,L747_A750del,Oncogenic,Gain-of-function,"16467085, 15118073, 15329413, 15118125", +EGFR,EGFR CTD,Oncogenic,Gain-of-function,"24120142, 22001862, 24292886, 20676128, 23007009", +EGFR,E746_S752delinsV,Oncogenic,Gain-of-function,"15118073, 15329413, 22483783, 25179728, 15710947, 15118125", +EGFR,K745M,Likely Neutral,Loss-of-function,21081186, +EGFR,E746V,Likely Oncogenic,Likely Gain-of-function,"16467085, 18000506", +EGFR,P596L,Likely Oncogenic,Likely Gain-of-function,"17177598, 23243055", +EGFR,S768_D770dup,Oncogenic,Gain-of-function,"23371856, 19536777, 24353160, 21764376, 18676761, 23749122, 15897572, 17686547", +EGFR,A859_L883delinsV,Likely Oncogenic,Likely Gain-of-function,18325048, +EGFR,P772_H773insYNP,Oncogenic,Gain-of-function,"23371856, 19536777, 24353160, 21764376, 18676761, 15897572, 17686547", +EGFR,P772_V774dup,Oncogenic,Gain-of-function,"23371856, 19536777, 24353160, 21764376, 18676761, 25179728, 15897572, 17686547", +EGFR,T710A,Likely Oncogenic,Likely Gain-of-function,23912954, +EGFR,C628Y,Likely Neutral,Neutral,24747966, +EGFR,P753S,Likely Oncogenic,Likely Gain-of-function,"16467085, 16106023, 25130612, 24934779", +EGFR,G598V,Oncogenic,Gain-of-function,"24120142, 17177598, 22588883", +EGFR,K745_A750del,Oncogenic,Gain-of-function,"15118073, 15329413, 25179728, 15118125", +EGFR,L838P,Likely Oncogenic,Likely Gain-of-function,21531810, +EGFR,E709V,Likely Oncogenic,Likely Gain-of-function,"21531810, 19536777, 26051236", +EGFR,T263P,Oncogenic,Gain-of-function,17177598, +EGFR,L692F,Likely Oncogenic,Likely Gain-of-function,23912954, +EGFR,K467T,Likely Oncogenic,Likely Gain-of-function,25633215, +EGFR,V774M,Likely Oncogenic,Likely Gain-of-function,21531810, +EGFR,L703P,Likely Oncogenic,Likely Gain-of-function,19020901, +EGFR,E746_T751delinsA,Oncogenic,Gain-of-function,"15118073, 15329413, 15710947, 15897572, 15118125", +EGFR,G857E,Likely Oncogenic,Likely Gain-of-function,"23139256, 18000506, 19238633, 25435280", +EGFR,E884K,Oncogenic,Gain-of-function,"16407879, 19015641", +EGFR,D770_P772dup,Oncogenic,Gain-of-function,"23371856, 19536777, 24353160, 21764376, 18676761, 23749122, 15897572, 17686547", +EGFR,N826Y,Likely Oncogenic,Likely Gain-of-function,"21531810, 19147750", +EGFR,L861P,Likely Oncogenic,Likely Gain-of-function,"21531810, 17177598, 18000506", +EGFR,T34_A289del,Oncogenic,Gain-of-function,27216155, +EGFR,V769_D770insGVV,Oncogenic,Gain-of-function,"23371856, 19536777, 24353160, 21764376, 18676761, 15897572, 17686547, 17192902", +EGFR,E931G,Likely Oncogenic,Likely Gain-of-function,17974985, +EGFR,L861Q,Oncogenic,Gain-of-function,"21531810, 18508816, 16467085, 17177598, 25668120, 21841502, 15897572, 21252719, 19536777, 18325048, 19147750, 26051236, 18676761, 23912954, 24457318, 22760226, 20808254, 23749122, 24285021", +EGFR,E746_S752delinsI,Oncogenic,Gain-of-function,"15118073, 15329413, 15118125, 17192902", +EGFR,Exon 20 insertion,Oncogenic,Gain-of-function,"23371856, 19536777, 24353160, 21764376, 18676761, 15897572, 17686547", +EGFR,S720P,Likely Oncogenic,Likely Gain-of-function,"22760226, 15897572", +EGFR,EGFRvII,Oncogenic,Gain-of-function,"24893890, 17189397", +EGFR,G810S,Likely Oncogenic,Gain-of-function,19147750, +EGFR,R776C,Likely Oncogenic,Gain-of-function,19147750, +EGFR,Y727H,Likely Oncogenic,Likely Gain-of-function,18000506, +EGFR,E330K,Oncogenic,Gain-of-function,24212795, +EGFR,G719C,Likely Oncogenic,Likely Gain-of-function,"21531810, 15118073, 19147750, 18261621, 26206867, 21841502", +EGFR,E734Q,Likely Oncogenic,Gain-of-function,20942962, +EGFR,L838V,Likely Oncogenic,Gain-of-function,19147750, +EGFR,K806A,Likely Oncogenic,Likely Gain-of-function,19536777, +EGFR,S645C,Likely Oncogenic,Likely Gain-of-function,27478040, +EGFR,S752_I759del,Likely Oncogenic,Likely Gain-of-function,"23371856, 19536777, 24353160, 21764376, 18676761, 15897572, 17686547, 17192902", +EGFR,E746_A750del,Oncogenic,Gain-of-function,"18508816, 18325048, 16467085, 15118073, 15329413, 18261621, 22483783, 25179728, 16373402, 15710947, 15897572, 15118125", +EGFR,G735S,Oncogenic,Gain-of-function,"18193092, 25435280", +EGFR,G465E,Likely Oncogenic,Likely Gain-of-function,26416732, +EGFR,S464L,Likely Oncogenic,Likely Gain-of-function,25633215, +EGFR,I941R,Likely Neutral,Likely Loss-of-function,24063894, +EGFR,Exon 19 insertion,Oncogenic,Gain-of-function,"21422421, 22190593", +EGFR,E709K,Oncogenic,Gain-of-function,"19726454, 23566546, 18000506, 25179728, 25130612, 23749122, 15710947, 26206867", +EGFR,G724S,Oncogenic,Gain-of-function,"16166444, 24894453, 24743239", +EGFR,G796S,Likely Oncogenic,Gain-of-function,18193092, +EGFR,V843I,Likely Oncogenic,Gain-of-function,"23380224, 21172876, 19536777, 25057940, 18000506, 18355544", +EGFR,A289V,Oncogenic,Gain-of-function,"24120142, 17177598, 22588883", +EGFR,I853T,Likely Neutral,Loss-of-function,19147750, +EGFR,V769M,Likely Oncogenic,Gain-of-function,"21531810, 20354512, 21764376, 23749122","Hellmann et al., JCO- PO, 2017 http://ascopubs.org/doi/full/10.1200/PO.16.00019" +EGFR,T785A,Likely Oncogenic,Gain-of-function,20942962, +EGFR,C797Y,Likely Oncogenic,Gain-of-function,20942962, +EGFR,L747_P753del,Oncogenic,Gain-of-function,"15118073, 15329413, 25179728, 15118125", +EGFR,P691S,Likely Oncogenic,Likely Gain-of-function,"22483783, 18000506", +EGFR,EGFR-RAD51 Fusion,Oncogenic,Gain-of-function,27102076, +EGFR,L747V,Likely Oncogenic,Likely Gain-of-function,"23242437, 22190593", +EGFR,Fusions,Likely Oncogenic,Likely Gain-of-function,"27102076, 23917401", +EGFR,L747_P753delinsS,Oncogenic,Gain-of-function,"18508816, 15118073, 15329413, 19147750, 25179728, 15710947, 15897572, 15118125", +EGFR,V742A,Likely Oncogenic,Gain-of-function,"21531810, 23605641, 19147750, 16152581", +EGFR,P848L,Likely Neutral,Likely Neutral,"23897956, 22848293, 25176975, 23912954, 17877814", +EGFR,I491M,Likely Oncogenic,Likely Neutral,25633215, +EGFR,A750_E758del,Oncogenic,Gain-of-function,"18325048, 15118073, 15329413, 15118125", +EGFR,D770_N771insD,Oncogenic,Gain-of-function,"23371856, 19536777, 24353160, 21764376, 18676761, 15897572, 17686547", +EGFR,Exon 19 deletion/insertion,Oncogenic,Gain-of-function,"15329413, 18000506, 15118125, 19536777, 18458038, 15118073, 22019513, 23566546, 23559152, 24457318, 22760226, 23749122, 17192902", +EGFR,N771_H773dup,Oncogenic,Gain-of-function,"23371856, 19536777, 24353160, 21764376, 18676761, 23912954, 15897572, 17686547", +EGFR,L747S,Likely Oncogenic,Likely Gain-of-function,"17973572, 18309959, 18645621, 19632948, 18981003", +EGFR,Y801H,Likely Oncogenic,Gain-of-function,"20942962, 17224267", +EGFR,S784F,Likely Oncogenic,Gain-of-function,"20522446, 21531810, 19147750, 21841502", +EGFR,E804G,Likely Oncogenic,Gain-of-function,18193092, +EGFR,E709G,Likely Oncogenic,Likely Gain-of-function,"21531810, 26051236, 23912954", +EGFR,A763_Y764insFQEA,Oncogenic,Gain-of-function,24353160, +EGFR,EGFRvIII,Oncogenic,Gain-of-function,"8895767, 17189397, 19324552, 8052651, 23777544, 12438278", +EGFR,R324L,Oncogenic,Gain-of-function,24212795, +EGFR,C797S,Likely Oncogenic,Likely Switch-of-function,25939061, +EGFR,Exon 19 deletion,Oncogenic,Gain-of-function,"15329413, 18000506, 15118125, 19536777, 18458038, 15118073, 22019513, 23566546, 23559152, 24457318, 22760226, 23749122, 17192902", +EGFR,R841K,Likely Neutral,Likely Loss-of-function,18193092, +EGFR,V765A,Likely Oncogenic,Likely Gain-of-function,15897572, +EGFR,H773Y,Likely Oncogenic,Likely Gain-of-function,"19536777, 17974985, 18676761", +EGFR,R108K,Oncogenic,Gain-of-function,"24120142, 17177598", +EGFR,R836C,Likely Oncogenic,Likely Gain-of-function,23912954, +EGFR,L858M,Likely Oncogenic,Likely Gain-of-function,25232377, +EGFR,Amplification,Oncogenic,Gain-of-function,"24120142, 10728703", +EGFR,L747_A750delinsP,Oncogenic,Gain-of-function,"18508816, 15118073, 15329413, 15118125, 17192902", +EGFR,A767_V769dup,Oncogenic,Gain-of-function,"23371856, 19536777, 24353160, 21764376, 18676761, 23912954, 23749122, 15897572, 17686547", +EGFR,L747_T751delinsP,Oncogenic,Gain-of-function,"15118073, 15329413, 15710947, 15118125", +EGFR,E746_T751insIP,Oncogenic,Gain-of-function,"18325048, 22190593", +EGFR,D770_N771insSVD,Oncogenic,Gain-of-function,"23371856, 19536777, 24353160, 21764376, 18676761, 15897572, 17686547", +EGFR,H870R,Likely Neutral,Likely Neutral,"19671738, 21841502", +EGFR,L747_S752del,Oncogenic,Gain-of-function,"16467085, 15118073, 15329413, 15118125, 17192902", +EGFR,EGFRvV,Oncogenic,Gain-of-function,"17189397, 1730638, 2790960", +EGFR,C620Y,Oncogenic,Gain-of-function,24747966, +EGFR,L833V,Oncogenic,Gain-of-function,"16205628, 21949883, 23912954, 25130612, 20808254, 21422421", +EGFR,L747F,Likely Oncogenic,Likely Gain-of-function,"16533793, 26773740, 24385129, 23485129, 26096169, 22190593", +EGFR,E709A,Likely Oncogenic,Gain-of-function,"21531810, 19671738, 23242437, 18261621, 23566546, 22483783, 23749122, 20479403, 15710947, 18372921, 21841502", +EGFR,V769_D770insASV,Oncogenic,Gain-of-function,"23371856, 19536777, 24353160, 21764376, 18676761, 15897572, 17686547", +EGFR,N826S,Oncogenic,Gain-of-function,"19147750, 15897572", +EGFR,E746G,Likely Oncogenic,Likely Gain-of-function,21531810, +EGFR,EGFR-KDD,Oncogenic,Gain-of-function,26286086, +EGFR,L747_T751del,Oncogenic,Gain-of-function,"18325048, 23242437, 15118073, 15329413, 23387505, 15897572, 15118125", +EGFR,H773insLGNP,Oncogenic,Gain-of-function,"23371856, 19536777, 24353160, 21764376, 18676761, 23749122, 15897572, 17686547", +EGFR,T790M,Oncogenic,Gain-of-function,"15728811, 18227510, 15737014", +EGFR,D587H,Likely Oncogenic,Gain-of-function,"26571394, 27245685", +NKX2-1,Amplification,Oncogenic,Gain-of-function,"17925434, 18212743, 22439932", +NKX2-1,Fusions,Likely Oncogenic,Likely Gain-of-function,21481790, +NKX2-1,TRA-NKX2-1 Fusion,Likely Oncogenic,Likely Gain-of-function,21481790, +NKX2-1,A339V,Likely Oncogenic,Gain-of-function,19176457, +NKX2-1,TRB-NKX2-1 Fusion,Likely Oncogenic,Likely Gain-of-function,21481790, +NKX2-1,IGH-NKX2 Fusion,Likely Oncogenic,Likely Gain-of-function,21481790, +EIF1AX,A113_splice,Oncogenic,Gain-of-function,26878173,"Krishnamoorthy et al. Abstract# 892, AACR 2016 http://cancerres.aacrjournals.org/content/76/14_Supplement/892" +ARID2,Deletion,Likely Oncogenic,Likely Loss-of-function,"23047306, 22095441, 15985610, 16847454", +ARID2,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,"23047306, 21822264, 15985610, 16847454", +BRD4,Fusions,Oncogenic,Likely Gain-of-function,"12543779, 23128391, 25564152", +BRD4,Amplification,Likely Oncogenic,Gain-of-function,"12192049, 19596781, 15456879", +BRD4,BRD4-NUT Fusion,Oncogenic,Gain-of-function,"23604113, 21447744, 25512383, 20676058, 17934517, 20871596", +HIST1H1C,S102F,Likely Oncogenic,Likely Loss-of-function,24362818, +ERRFI1,Deletion,Likely Oncogenic,Likely Loss-of-function,"16648858, 21113414", +ERRFI1,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,"16648858, 17599051, 26280531, 21576352, 11003669, 22701735, 16247031, 11843178, 16819504, 18046415, 25735773, 12833145, 20421427, 24550739, 15556944", +CHEK2,S428F,Likely Oncogenic,Likely Loss-of-function,"16998506, 15649950", +CHEK2,R117G,Likely Oncogenic,Loss-of-function,"16835864, 16982735", +CHEK2,P85L,Likely Neutral,Neutral,"16998506, 15649950", +CHEK2,E321K,Likely Oncogenic,Loss-of-function,16835864, +CHEK2,E161del,Likely Oncogenic,Loss-of-function,16982735, +CHEK2,K373E,Oncogenic,Loss-of-function,27716909, +CHEK2,H371Y,Likely Oncogenic,Loss-of-function,"21618645, 25884806", +CHEK2,I157T,Inconclusive,Inconclusive,"16816021, 11571648, 15239132, 11053450, 14612911, 15492928, 11298456, 12049740", +PAK1,Amplification,Oncogenic,Gain-of-function,"21482786, 22105362", +TMPRSS2,M160V,Likely Neutral,Neutral,"11745466, 25040002", +TMPRSS2,TMPRSS2-ETV5 Fusion,Likely Oncogenic,Likely Gain-of-function,18172298, +TMPRSS2,T75M,Likely Neutral,Neutral,"11745466, 25040002", +TMPRSS2,TMPRSS2-ERG Fusion,Oncogenic,Gain-of-function,"7731694, 16213704, 17043636", +TMPRSS2,TMPRSS2-ETV4 Fusion,Likely Oncogenic,Likely Gain-of-function,16585160, +TMPRSS2,Fusions,Likely Oncogenic,Likely Gain-of-function,"16254181, 18283340", +TMPRSS2,TMPRSS2-ETV1 Fusion,Oncogenic,Gain-of-function,"18563191, 23512661", +H3F3A,K28M,Likely Oncogenic,Likely Switch-of-function,"21685365, 22286061", +H3F3A,G35R,Likely Oncogenic,Likely Switch-of-function,"21685365, 23079654, 22286061", +H3F3A,G35V,Likely Oncogenic,Likely Switch-of-function,"21685365, 23079654, 22286061", +ELF3,R331P,Likely Oncogenic,Likely Loss-of-function,17148437, +ELF3,I279P,Likely Oncogenic,Likely Loss-of-function,17148437, +ELF3,K320E,Likely Neutral,Likely Neutral,17148437, +ELF3,S330A,Likely Neutral,Likely Neutral,17148437, +ELF3,A312P,Likely Oncogenic,Likely Loss-of-function,17148437, +ELF3,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,"14976186, 17148437", +ELF3,S308A,Likely Neutral,Likely Neutral,17148437, +ROS1,G2032R,Likely Oncogenic,Likely Gain-of-function,"25351743, 24047073, 24047072, 23724914, 27401242, 25688157", +ROS1,L1951R,Inconclusive,Inconclusive,25351743, +ROS1,YWHAE-ROS1 Fusion,Likely Oncogenic,Likely Gain-of-function,24875859, +ROS1,ROS1-CD74 Fusion,Oncogenic,Gain-of-function,"22919003, 22215748, 18083107, 22327623", +ROS1,TFG-ROS1 Fusion,Likely Oncogenic,Likely Gain-of-function,24875859, +ROS1,G1971E,Likely Oncogenic,Likely Gain-of-function,24218589, +ROS1,SLC34A2-ROS1 Fusion,Oncogenic,Gain-of-function,"22919003, 22215748, 22327623", +ROS1,G2101A,Likely Oncogenic,Likely Gain-of-function,"22235099, 25688157, 24675041", +ROS1,TPM3-ROS1 Fusion,Oncogenic,Gain-of-function,22327623, +ROS1,S1986Y,Likely Oncogenic,Likely Gain-of-function,27401242, +ROS1,MSN-ROS1 Fusion,Likely Oncogenic,Likely Gain-of-function,25264305, +ROS1,CCDC6-ROS1 Fusion,Likely Oncogenic,Likely Gain-of-function,"22975805, 25870798", +ROS1,CD74-ROS1 Fusion,Oncogenic,Gain-of-function,"22919003, 22215748, 18083107, 22327623", +ROS1,E1935G,Likely Oncogenic,Likely Gain-of-function,24218589, +ROS1,D2033N,Likely Oncogenic,Likely Gain-of-function,26673800, +ROS1,V2098I,Likely Oncogenic,Likely Gain-of-function,24218589, +ROS1,LRIG3-ROS1 Fusion,Oncogenic,Gain-of-function,22327623, +ROS1,LIMA1-ROS1 Fusion,Likely Oncogenic,Likely Gain-of-function,25264305, +ROS1,Amplification,Likely Oncogenic,Likely Gain-of-function,25978031, +ROS1,C2060G,Likely Oncogenic,Likely Gain-of-function,24218589, +ROS1,CEP85L-ROS1 Fusion,Likely Oncogenic,Likely Gain-of-function,"25204415, 23637631", +ROS1,KDELR2-ROS1 Fusion,Likely Oncogenic,Likely Gain-of-function,22980976, +ROS1,L1947R,Likely Oncogenic,Likely Gain-of-function,24218589, +ROS1,Fusions,Likely Oncogenic,Likely Gain-of-function,"22919003, 23719267, 22215748", +ROS1,SDC4-ROS1 Fusion,Oncogenic,Gain-of-function,22327623, +ROS1,FIG-ROS1 Fusion,Oncogenic,Gain-of-function,"12661006, 2827175", +ROS1,S1986F,Likely Oncogenic,Likely Gain-of-function,27401242, +ROS1,EZR-ROS1 Fusion,Oncogenic,Gain-of-function,22327623, +ASXL2,Deletion,Likely Oncogenic,Likely Loss-of-function,24973361,"Li et al. Abstract# 1509, ASH 2016 http://www.bloodjournal.org/content/128/22/1509" +ASXL2,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,24973361,"Li et al. Abstract# 1509, ASH 2016 http://www.bloodjournal.org/content/128/22/1509" +CDH1,A634V,Oncogenic,Loss-of-function,12588804, +CDH1,D257N,Likely Oncogenic,Likely Loss-of-function,24690483, +CDH1,R732Q,Likely Oncogenic,Likely Loss-of-function,"15235021, 17545690", +CDH1,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,"8934538, 2070412, 9515965, 17522512", +CDH1,A298T,Likely Oncogenic,Likely Loss-of-function,24204729, +CDH1,D254N,Oncogenic,Loss-of-function,26123647, +CDH1,Deletion,Likely Oncogenic,Likely Loss-of-function,"23812922, 2070412, 23341533, 19168852, 9515965, 24037103", +CDH1,A617T,Likely Oncogenic,Loss-of-function,12588804, +CDH1,Epigenetic Silencing,Likely Oncogenic,Likely Loss-of-function,"11313896, 7543680", +CDH1,T340A,Oncogenic,Loss-of-function,12588804, +EPCAM,3' Deletion,Oncogenic,Loss-of-function,21145788, +TOP1,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,"15829965, 2902925, 12042765, 25693836", +EP300,C1385,Likely Oncogenic,Loss-of-function,18273021, +EP300,Y1414C,Likely Oncogenic,Loss-of-function,25151357, +EP300,R1627,Likely Oncogenic,Loss-of-function,18273021, +EP300,Deletion,Likely Oncogenic,Likely Loss-of-function,"10700188, 12402157, 12237408", +EP300,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,"10700188, 15156177, 12402157, 12237408", +EP300,EP300-MOZ Fusion,Likely Oncogenic,Gain-of-function,"10824998, 23307074, 11243405", +EP300,Fusions,Likely Oncogenic,Likely Gain-of-function,"25943178, 26293203, 23307074", +EP300,P1502L,Likely Oncogenic,Loss-of-function,25151357, +EP300,EP300-MLL Fusion,Likely Oncogenic,Gain-of-function,"18778367, 23307074, 9389684, 20980053", +EP300,D1399Y,Likely Oncogenic,Loss-of-function,"12586840, 25151357", +EPAS1,A530V,Likely Oncogenic,Likely Gain-of-function,"22931260, 23418310", +EPAS1,P531A,Likely Oncogenic,Likely Gain-of-function,"23054256, 14691554, 12086860", +EPAS1,P531S,Likely Oncogenic,Likely Gain-of-function,"22931260, 23418310", +EPAS1,Y532C,Likely Oncogenic,Likely Gain-of-function,"23361906, 23653463", +EPAS1,533_534del,Likely Oncogenic,Likely Gain-of-function,"22931260, 23418310", +EPAS1,A530T,Likely Oncogenic,Likely Gain-of-function,"22931260, 23418310", +EPAS1,534_536del,Likely Oncogenic,Likely Gain-of-function,"22931260, 23418310", +EPAS1,P531L,Likely Oncogenic,Likely Gain-of-function,"22931260, 23418310", +TP53,R282Q,Likely Oncogenic,Likely Loss-of-function,18453682, +TP53,R283Q,Likely Oncogenic,Likely Loss-of-function,7651437, +TP53,L344P,Likely Oncogenic,Loss-of-function,"19454241, 20978130, 19106109", +TP53,H168N,Likely Oncogenic,Likely Loss-of-function,19462533, +TP53,F338I,Likely Oncogenic,Likely Loss-of-function,"19454241, 20978130", +TP53,R175L,Likely Oncogenic,Loss-of-function,"15781620, 18762572, 25584008", +TP53,P219S,Likely Oncogenic,Loss-of-function,"10229196, 25584008", +TP53,L330H,Likely Oncogenic,Likely Loss-of-function,"19454241, 20978130", +TP53,G245A,Likely Oncogenic,Likely Loss-of-function,20589832, +TP53,C238S,Likely Oncogenic,Loss-of-function,19681600, +TP53,H193R,Likely Oncogenic,Likely Loss-of-function,9627118, +TP53,S121F,Likely Oncogenic,Likely Gain-of-function,15781620, +TP53,R337H,Likely Oncogenic,Likely Loss-of-function,"19454241, 25584008, 11481490", +TP53,R158C,Likely Oncogenic,Likely Loss-of-function,17947339, +TP53,R267P,Likely Oncogenic,Likely Gain-of-function,"23264849, 22989750", +TP53,H214R,Likely Oncogenic,Likely Loss-of-function,"20407015, 26619011", +TP53,L348F,Likely Oncogenic,Likely Loss-of-function,19454241, +TP53,K291E,Likely Oncogenic,Likely Loss-of-function,"15781620, 8023157, 26619011, 11900253", +TP53,Y220S,Likely Oncogenic,Loss-of-function,15977174, +TP53,K120N,Likely Oncogenic,Loss-of-function,7651437, +TP53,C277W,Likely Oncogenic,Likely Loss-of-function,24814347, +TP53,R290G,Likely Oncogenic,Likely Loss-of-function,"15781620, 8023157, 26619011, 11900253", +TP53,G244S,Oncogenic,Loss-of-function,26818906, +TP53,P278R,Likely Oncogenic,Loss-of-function,21760996, +TP53,E258V,Likely Oncogenic,Likely Loss-of-function,21445056, +TP53,S215G,Oncogenic,Loss-of-function,"17724467, 8023157, 26619011, 22862161, 11900253", +TP53,A161S,Likely Oncogenic,Loss-of-function,25119136, +TP53,R280T,Likely Oncogenic,Likely Loss-of-function,22999923, +TP53,K292T,Likely Oncogenic,Likely Loss-of-function,"15781620, 8023157, 26619011, 11900253", +TP53,M133K,Likely Oncogenic,Likely Loss-of-function,25408419, +TP53,Q331H,Likely Oncogenic,Likely Loss-of-function,"26619011, 20978130", +TP53,M133T,Likely Oncogenic,Likely Loss-of-function,21311097, +TP53,R181C,Likely Oncogenic,Loss-of-function,"10229196, 20471942", +TP53,DNA binding domain missense mutations,Oncogenic,Loss-of-function,"8023157, 11900253", +TP53,V197L,Likely Oncogenic,Likely Loss-of-function,11668476, +TP53,E326L,Likely Oncogenic,Loss-of-function,26748848, +TP53,C176R,Likely Oncogenic,Loss-of-function,8633021, +TP53,R290H,Likely Oncogenic,Likely Loss-of-function,10435620, +TP53,T150I,Likely Oncogenic,Likely Loss-of-function,10229196, +TP53,R175C,Likely Oncogenic,Likely Loss-of-function,"9632751, 26619011, 22955915", +TP53,G245D,Likely Oncogenic,Likely Loss-of-function,"25119136, 22803791, 22214764", +TP53,G266R,Likely Oncogenic,Loss-of-function,16827139, +TP53,R273L,Likely Oncogenic,Loss-of-function,"8023157, 15037740, 11900253", +TP53,G244D,Likely Oncogenic,Likely Loss-of-function,12901798, +TP53,K120E,Oncogenic,Loss-of-function,"18524770, 24814347, 17189187", +TP53,I162M,Likely Oncogenic,Likely Loss-of-function,"15781620, 8023157, 11900253", +TP53,G266E,Likely Oncogenic,Likely Loss-of-function,17724467, +TP53,G356A,Inconclusive,Inconclusive,20978130, +TP53,C242S,Likely Oncogenic,Loss-of-function,20407015, +TP53,P316L,Likely Oncogenic,Likely Loss-of-function,"10618702, 2553699, 20010306", +TP53,H178D,Likely Oncogenic,Likely Loss-of-function,24814347, +TP53,R337L,Likely Oncogenic,Likely Loss-of-function,"19454241, 20978130, 11481490", +TP53,I254T,Oncogenic,Loss-of-function,25584008, +TP53,S241F,Likely Oncogenic,Likely Loss-of-function,21383700, +TP53,R110L,Likely Oncogenic,Likely Loss-of-function,"21445056, 16778209", +TP53,T329I,Inconclusive,Inconclusive,20978130, +TP53,H168R,Likely Oncogenic,Loss-of-function,18996393, +TP53,V218dup,Oncogenic,Loss-of-function,"8023157, 11900253", +TP53,R280A,Likely Oncogenic,Likely Loss-of-function,"18524770, 24814347, 17189187", +TP53,K292I,Likely Oncogenic,Likely Gain-of-function,"15781620, 8023157, 11900253", +TP53,Y234H,Likely Oncogenic,Loss-of-function,22710932, +TP53,R280K,Oncogenic,Loss-of-function,24714748, +TP53,Y163C,Likely Oncogenic,Loss-of-function,"8023157, 23246812, 15037740, 25584008, 11900253, 15077194", +TP53,I195T,Likely Oncogenic,Likely Loss-of-function,"8023157, 11900253, 12700230", +TP53,L330R,Likely Oncogenic,Likely Loss-of-function,"19454241, 20978130", +TP53,V274F,Likely Oncogenic,Likely Loss-of-function,12782597, +TP53,P151H,Likely Oncogenic,Likely Loss-of-function,"8023157, 22908277, 11900253", +TP53,P151A,Likely Oncogenic,Loss-of-function,20407015, +TP53,R337P,Likely Oncogenic,Likely Loss-of-function,"19454241, 20978130, 11481490", +TP53,R342P,Likely Oncogenic,Loss-of-function,"19454241, 20978130", +TP53,R158L,Likely Oncogenic,Loss-of-function,"15037740, 25584008, 16861262", +TP53,R181P,Likely Oncogenic,Loss-of-function,20471942, +TP53,R337C,Likely Oncogenic,Loss-of-function,"19454241, 17311302, 16007150, 19106109, 11753428", +TP53,L330P,Likely Oncogenic,Likely Loss-of-function,20978130, +TP53,E286K,Likely Oncogenic,Loss-of-function,15037740, +TP53,P151S,Oncogenic,Loss-of-function,2857548, +TP53,C277R,Likely Oncogenic,Likely Loss-of-function,7651437, +TP53,P250L,Likely Oncogenic,Likely Loss-of-function,21445056, +TP53,M237K,Likely Oncogenic,Likely Loss-of-function,20505364, +TP53,R248W,Likely Oncogenic,Loss-of-function,"18762571, 10229196, 25584008", +TP53,H193N,Likely Oncogenic,Loss-of-function,19462533, +TP53,R213Q,Likely Oncogenic,Loss-of-function,10871862, +TP53,P153H,Likely Oncogenic,Likely Loss-of-function,"15781620, 8023157, 11900253", +TP53,Y220C,Oncogenic,Loss-of-function,"23315175, 15037740, 23630318", +TP53,H115N,Inconclusive,Inconclusive,19462533, +TP53,H233N,Likely Oncogenic,Likely Loss-of-function,"19462533, 26619011", +TP53,V173E,Likely Oncogenic,Loss-of-function,9472631, +TP53,H179Q,Likely Oncogenic,Loss-of-function,22540896, +TP53,Y205C,Likely Oncogenic,Loss-of-function,15037740, +TP53,S121C,Inconclusive,Inconclusive,15781620, +TP53,K291Q,Likely Oncogenic,Likely Loss-of-function,"15781620, 8023157, 11900253", +TP53,S240R,Likely Oncogenic,Likely Loss-of-function,10229196, +TP53,R249W,Oncogenic,Loss-of-function,23612969, +TP53,R248Q,Likely Oncogenic,Likely Loss-of-function,"24814347, 21445056, 16778209", +TP53,P47S,Likely Neutral,Neutral,25584008, +TP53,R181L,Likely Oncogenic,Likely Loss-of-function,20471942, +TP53,R273G,Likely Oncogenic,Likely Loss-of-function,"24677579, 26619011", +TP53,S215C,Likely Oncogenic,Likely Loss-of-function,"15781620, 26619011, 12917626", +TP53,P278S,Likely Oncogenic,Loss-of-function,22989750, +TP53,R273H,Oncogenic,Loss-of-function,"26181206, 15037740, 25584008", +TP53,C238F,Likely Oncogenic,Loss-of-function,20407015, +TP53,T123A,Likely Neutral,Likely Neutral,"16687402, 18996393", +TP53,H214Q,Likely Oncogenic,Likely Loss-of-function,"15781620, 26619011", +TP53,F328V,Likely Oncogenic,Likely Loss-of-function,19454241, +TP53,C242Y,Likely Oncogenic,Loss-of-function,20407015, +TP53,Y236D,Likely Oncogenic,Loss-of-function,8633021, +TP53,L348S,Likely Oncogenic,Likely Loss-of-function,20978130, +TP53,I255F,Likely Oncogenic,Likely Loss-of-function,25408419, +TP53,G245S,Oncogenic,Loss-of-function,"2358418, 15037740", +TP53,G244R,Oncogenic,Loss-of-function,11160722, +TP53,Y236S,Likely Oncogenic,Loss-of-function,11429705, +TP53,C135R,Likely Oncogenic,Loss-of-function,17914575, +TP53,DNA binding domain deletions,Oncogenic,Loss-of-function,"8023157, 11900253", +TP53,H179N,Likely Oncogenic,Likely Loss-of-function,19462533, +TP53,C176F,Likely Oncogenic,Loss-of-function,22090360, +TP53,R156C,Likely Oncogenic,Likely Loss-of-function,"15781620, 8023157, 11900253", +TP53,R273C,Likely Oncogenic,Likely Loss-of-function,"15037740, 23863845, 11900253, 23612969", +TP53,K120R,Likely Oncogenic,Loss-of-function,"7651437, 17189187", +TP53,DNA binding domain insertions,Oncogenic,Loss-of-function,"8023157, 11900253", +TP53,C135Y,Likely Oncogenic,Switch-of-function,22847613, +TP53,I251S,Likely Oncogenic,Likely Loss-of-function,26748848, +TP53,V272L,Likely Oncogenic,Likely Loss-of-function,"20407015, 26619011", +TP53,C229R,Likely Oncogenic,Likely Loss-of-function,25584008, +TP53,R249S,Likely Oncogenic,Likely Loss-of-function,"21445056, 18996393, 14741214", +TP53,K120A,Likely Oncogenic,Likely Loss-of-function,"24814347, 16687402", +TP53,C135S,Likely Oncogenic,Likely Loss-of-function,"17914575, 8023157, 11900253", +TP53,R181H,Likely Oncogenic,Loss-of-function,20471942, +TP53,R282W,Likely Oncogenic,Likely Loss-of-function,21445056, +TP53,A347T,Likely Oncogenic,Likely Loss-of-function,"19454241, 20978130", +TP53,R248L,Likely Oncogenic,Likely Loss-of-function,"26748848, 25584008", +TP53,N235D,Oncogenic,Loss-of-function,25584008, +TP53,H179Y,Likely Oncogenic,Loss-of-function,17530187, +TP53,V197E,Likely Oncogenic,Likely Loss-of-function,25408419, +TP53,V143A,Likely Oncogenic,Likely Loss-of-function,10435620, +TP53,Y234C,Likely Oncogenic,Loss-of-function,"10229196, 26748848, 16861262", +TP53,S241Y,Likely Oncogenic,Loss-of-function,25584008, +TP53,V272M,Likely Oncogenic,Likely Loss-of-function,"15037740, 11870884", +TP53,R156H,Likely Oncogenic,Loss-of-function,10435620, +TP53,P278L,Likely Oncogenic,Loss-of-function,16861262, +TP53,R249M,Likely Oncogenic,Loss-of-function,"17999388, 15037740", +TP53,C242F,Likely Oncogenic,Likely Loss-of-function,17401432, +TP53,F212Y,Inconclusive,Inconclusive,15781620, +TP53,V157F,Likely Oncogenic,Likely Loss-of-function,"21561095, 15037740, 16778209", +TP53,Y236C,Likely Oncogenic,Loss-of-function,16827139, +TP53,V173M,Likely Oncogenic,Loss-of-function,15037740, +TP53,R110P,Likely Oncogenic,Likely Loss-of-function,21445056, +TP53,E221Q,Inconclusive,Inconclusive,15781620, +TP53,V157D,Oncogenic,Loss-of-function,23981578, +TP53,S121A,Likely Neutral,Likely Gain-of-function,15781620, +TP53,E285K,Likely Oncogenic,Likely Loss-of-function,20407015, +TP53,C141Y,Likely Oncogenic,Likely Loss-of-function,15037740, +TP53,R158H,Likely Oncogenic,Loss-of-function,"10229196, 25584008", +TP53,P278A,Likely Oncogenic,Likely Loss-of-function,24076587, +TP53,L344R,Likely Oncogenic,Likely Loss-of-function,"19454241, 20978130", +TP53,F341C,Likely Oncogenic,Likely Loss-of-function,"19454241, 20978130", +TP53,Y163N,Likely Oncogenic,Likely Loss-of-function,10229196, +TP53,K120M,Oncogenic,Loss-of-function,17189187, +TP53,R248K,Likely Oncogenic,Likely Loss-of-function,7651437, +TP53,A161T,Likely Oncogenic,Likely Loss-of-function,"21232794, 16827139", +TP53,H214N,Likely Oncogenic,Likely Loss-of-function,19462533, +TP53,R175H,Oncogenic,Loss-of-function,"15781620, 10713666, 21445056, 25584008, 22114072", +TP53,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,"19336573, 27759562, 16007150, 11753428, 11900253, 21467160", +TP53,Q331R,Likely Oncogenic,Likely Loss-of-function,20978130, +TP53,Q144P,Likely Oncogenic,Likely Loss-of-function,10229196, +TP53,F134Y,Likely Oncogenic,Likely Loss-of-function,"26619011, 25584008", +TP53,P152L,Likely Oncogenic,Likely Loss-of-function,25584008, +TP53,Q144R,Likely Oncogenic,Likely Loss-of-function,"15781620, 8023157, 26619011, 11900253", +TP53,H168Y,Likely Oncogenic,Likely Loss-of-function,10229196, +TP53,G245C,Likely Oncogenic,Likely Loss-of-function,"15037740, 22803791", +TP53,N239S,Oncogenic,Loss-of-function,22553460, +TP53,S121Y,Inconclusive,Inconclusive,15781620, +TP53,S241T,Likely Oncogenic,Loss-of-function,11896595, +TP53,C277Q,Likely Oncogenic,Likely Loss-of-function,7651437, +TP53,G334R,Likely Neutral,Neutral,25584008, +TP53,R267Q,Likely Oncogenic,Likely Loss-of-function,"10435620, 25584008", +TP53,G199R,Likely Oncogenic,Likely Loss-of-function,10229196, +TP53,L145R,Oncogenic,Loss-of-function,"8023157, 11900253", +TP53,H193P,Likely Oncogenic,Loss-of-function,25584008, +TP53,R202S,Likely Oncogenic,Likely Loss-of-function,10229196, +TP53,H179L,Oncogenic,Loss-of-function,23150443, +TP53,Deletion,Likely Oncogenic,Likely Loss-of-function,"26982726, 27759562, 19477430, 11900253, 12584563", +TP53,D186A,Likely Oncogenic,Likely Loss-of-function,24814347, +TP53,V173L,Likely Oncogenic,Loss-of-function,15037740, +TP53,E180K,Likely Oncogenic,Loss-of-function,"24814347, 20471942", +TP53,R273K,Likely Oncogenic,Loss-of-function,7651437, +TP53,H297N,Likely Neutral,Likely Neutral,19462533, +TP53,C275S,Likely Oncogenic,Loss-of-function,25584637, +TP53,E285V,Oncogenic,Loss-of-function,"18762572, 25584008", +TP53,H179R,Likely Oncogenic,Loss-of-function,"17361096, 22427690", +TP53BP1,Deletion,Likely Oncogenic,Likely Loss-of-function,"16260621, 22915756", +TP53BP1,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,23103855, +SMAD2,Y426A,Likely Oncogenic,Likely Loss-of-function,"11779503, 9463378", +SMAD2,S276L,Likely Oncogenic,Likely Loss-of-function,23139211, +SMAD2,N387P,Inconclusive,Inconclusive,11779503, +SMAD2,V319D,Likely Oncogenic,Likely Loss-of-function,11274206, +SMAD2,R428A,Inconclusive,Inconclusive,11779503, +SMAD2,Deletion,Likely Oncogenic,Loss-of-function,"15133179, 20010874, 16382155, 18618014, 12384562, 22204491, 19276350, 20852387", +SMAD2,K375A,Inconclusive,Inconclusive,11779503, +SMAD2,K420A,Likely Oncogenic,Likely Loss-of-function,"14729957, 11779503", +SMAD2,R310H,Likely Oncogenic,Likely Loss-of-function,11274206, +SMAD2,R321Q,Likely Oncogenic,Loss-of-function,"16828225, 20937913", +SMAD2,P305L,Likely Oncogenic,Likely Loss-of-function,23139211, +SMAD2,D300H,Likely Oncogenic,Likely Loss-of-function,"11274206, 11779503", +SMAD2,W368H,Likely Neutral,Likely Neutral,"11274206, 11779503", +SMAD2,Y406H,Inconclusive,Inconclusive,11779503, +SMAD2,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,"12894231, 23139211, 15711891, 11779503", +SMAD2,D300N,Likely Oncogenic,Likely Loss-of-function,23139211, +SMAD2,D450H,Likely Oncogenic,Likely Loss-of-function,11779503, +SMAD2,T413N,Likely Oncogenic,Likely Loss-of-function,23139211, +SMAD2,D450E,Likely Oncogenic,Likely Loss-of-function,23139211, +SMAD2,S467P,Likely Oncogenic,Likely Loss-of-function,23139211, +SMAD2,F346V,Likely Neutral,Likely Neutral,11274206, +SMAD3,D408Y,Likely Oncogenic,Loss-of-function,23139211, +SMAD3,Y238A,Likely Oncogenic,Likely Loss-of-function,21949838, +SMAD3,V277D,Likely Oncogenic,Loss-of-function,10092624, +SMAD3,Y298A,Likely Oncogenic,Likely Loss-of-function,21949838, +SMAD3,R292A,Likely Oncogenic,Likely Loss-of-function,21949838, +SMAD3,R287A,Likely Oncogenic,Loss-of-function,17994767, +SMAD3,Y384A,Likely Oncogenic,Likely Loss-of-function,21949838, +SMAD3,R243A,Likely Oncogenic,Likely Loss-of-function,21949838, +SMAD3,D258N,Likely Oncogenic,Loss-of-function,23139211, +SMAD3,D408H,Likely Oncogenic,Loss-of-function,21949838, +SMAD3,Y297A,Likely Oncogenic,Likely Loss-of-function,21949838, +SMAD3,V356R,Likely Oncogenic,Likely Loss-of-function,21949838, +SMAD3,Y226A,Likely Oncogenic,Likely Loss-of-function,21949838, +SMAD3,R373H,Likely Oncogenic,Likely Loss-of-function,16828225, +SMAD3,R373Q,Likely Oncogenic,Loss-of-function,23139211, +SMAD3,D408E,Likely Oncogenic,Loss-of-function,10092624, +SMAD3,R268A,Likely Oncogenic,Loss-of-function,21949838, +SMAD3,W406A,Likely Oncogenic,Likely Loss-of-function,21949838, +SMAD3,Y237A,Likely Neutral,Neutral,17994767, +SMAD3,S425C,Likely Oncogenic,Loss-of-function,23139211, +SMAD3,P336S,Likely Oncogenic,Loss-of-function,23139211, +SMAD3,E239A,Likely Oncogenic,Loss-of-function,17994767, +SMAD3,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,11691834, +SMAD3,K341A,Likely Oncogenic,Likely Loss-of-function,21949838, +SMAD3,Deletion,Likely Oncogenic,Likely Loss-of-function,"14647420, 18852474, 9753318, 16951153", +SMAD4,R420H,Likely Oncogenic,Likely Neutral,"11274206, 11779503", +SMAD4,K507A,Likely Oncogenic,Likely Loss-of-function,11779503, +SMAD4,W509R,Inconclusive,Inconclusive,22316667, +SMAD4,D537Y,Oncogenic,Loss-of-function,"23139211, 14715079", +SMAD4,Y513A,Inconclusive,Inconclusive,11779503, +SMAD4,R515A,Likely Oncogenic,Loss-of-function,11779503, +SMAD4,V370D,Likely Oncogenic,Likely Loss-of-function,"9214508, 11274206, 10092624, 19139564, 11779503", +SMAD4,W398V,Inconclusive,Inconclusive,11274206, +SMAD4,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,"23139211, 10340381, 15711891, 9094310, 11553622", +SMAD4,P130S,Likely Oncogenic,Loss-of-function,14647410, +SMAD4,P102L,Likely Oncogenic,Likely Loss-of-function,14647410, +SMAD4,D493A,Likely Oncogenic,Likely Loss-of-function,15350224, +SMAD4,L43V,Likely Oncogenic,Likely Loss-of-function,14647410, +SMAD4,H132Y,Likely Oncogenic,Likely Loss-of-function,25275298, +SMAD4,R361C,Likely Oncogenic,Loss-of-function,"9214508, 14647410, 26488212, 10092624", +SMAD4,R378A,Likely Oncogenic,Likely Loss-of-function,15350224, +SMAD4,K428A,Likely Oncogenic,Likely Loss-of-function,11779503, +SMAD4,A532H,Likely Oncogenic,Loss-of-function,11274206, +SMAD4,D493H,Likely Oncogenic,Loss-of-function,"11274206, 19139564", +SMAD4,D351H,Likely Oncogenic,Loss-of-function,"9214508, 14647410, 11274206, 11779503, 14715079", +SMAD4,R496H,Likely Oncogenic,Loss-of-function,26488212, +SMAD4,V465M,Inconclusive,Inconclusive,22316667, +SMAD4,C324Y,Likely Oncogenic,Likely Loss-of-function,22109972, +SMAD4,D357Y,Likely Oncogenic,Loss-of-function,14715079, +SMAD4,Deletion,Likely Oncogenic,Loss-of-function,"22321641, 25893305, 9482899, 10626800, 9506519, 17114584, 19841536, 10773876", +SMAD4,G508S,Likely Oncogenic,Likely Loss-of-function,"9214508, 9153220", +SMAD4,E330K,Likely Oncogenic,Loss-of-function,26488212, +SMAD4,R515G,Likely Oncogenic,Loss-of-function,14647410, +SMAD4,Y353L,Likely Oncogenic,Likely Loss-of-function,26619011, +SMAD4,E330A,Likely Oncogenic,Loss-of-function,17994767, +SMAD4,R100T,Likely Oncogenic,Loss-of-function,"14647410, 10092624", +SMAD4,E330G,Likely Oncogenic,Likely Loss-of-function,22316667, +SMAD4,R441P,Likely Neutral,Likely Neutral,"11274206, 11779503, 10822381", +SMAD4,D537E,Likely Oncogenic,Loss-of-function,"9214508, 23139211, 14715079", +SMAD4,K507Q,Likely Oncogenic,Likely Loss-of-function,14647410, +SMAD4,G419V,Likely Oncogenic,Loss-of-function,26488212, +SMAD4,R497H,Likely Oncogenic,Loss-of-function,14647410, +CDK4,K22A,Oncogenic,Gain-of-function,"9426066, 9712735, 9228064", +CDK4,Amplification,Oncogenic,Gain-of-function,"20534551, 8101826, 10970848", +CDK4,R24C,Oncogenic,Gain-of-function,"11606789, 11756559", +AURKB,Overexpression,Likely Oncogenic,Likely Gain-of-function,"17344846, 26240282, 18347165, 16222316", +AURKB,Amplification,Likely Oncogenic,Likely Gain-of-function,26240282, +CDK6,A197T,Likely Neutral,Loss-of-function,23918663, +CDK6,Amplification,Oncogenic,Gain-of-function,"17989712, 23127611, 11940479, 20534551, 24736461, 22476749, 12900351, 19145199, 24764564", +Other Biomarkers,MSI-H,Oncogenic,null,, +FBXW7,Deletion,Likely Oncogenic,Likely Loss-of-function,"25314076, 27764699, 18367647, 15103331", +FBXW7,R505C,Oncogenic,Loss-of-function,"27147599, 17646408, 17575125, 23228967, 24838835, 22608923, 23095493", +FBXW7,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,"17646409, 15103331, 18094723", +FBXW7,R479Q,Oncogenic,Loss-of-function,"17646408, 17909001, 23228967, 17646409", +FBXW7,R482Q,Oncogenic,Loss-of-function,23676439, +FBXW7,R465H,Likely Oncogenic,Loss-of-function,"27147599, 24912918, 23228967, 17575125, 22608923", +FBXW7,D520N,Likely Oncogenic,Likely Loss-of-function,"11565034, 19420964", +FBXW7,R505L,Oncogenic,Loss-of-function,17646409, +FBXW7,S462Y,Likely Neutral,Likely Neutral,27147599, +FBXW7,Copy Number Loss,Oncogenic,Loss-of-function,"19739118, 24884509, 18367647, 18094723, 25555218, 22673505", +FBXW7,T205A,Likely Neutral,Likely Gain-of-function,22608923, +FBXW7,S562L,Likely Neutral,Neutral,24838835, +FBXW7,R479H,Likely Oncogenic,Loss-of-function,17575125, +FBXW7,R465C,Oncogenic,Loss-of-function,"17646408, 17909001, 17646409, 23095493", +FBXW7,S227A,Likely Oncogenic,Loss-of-function,21620836, +FBXW7,K11R,Likely Oncogenic,Likely Loss-of-function,20815813, +FBXW7,R479L,Likely Oncogenic,Loss-of-function,"24912918, 22608923", +FBXW7,G423R,Likely Oncogenic,Likely Loss-of-function,"24838835, 26619011", +FBXW7,R658Q,Likely Oncogenic,Likely Loss-of-function,"27147599, 26619011", +FBXW7,I347M,Likely Neutral,Likely Neutral,27147599, +FBXW7,R689Q,Likely Oncogenic,Likely Loss-of-function,"27147599, 26619011", +CDK8,Amplification,Oncogenic,Gain-of-function,18794900, +CDKN1A,S31R,Inconclusive,Inconclusive,"7655464, 20127253, 18046503, 17293864", +CDKN1A,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,"23159848, 24317508", +CDKN1A,Deletion,Likely Oncogenic,Likely Loss-of-function,"19106607, 25483104, 23624841, 15960923", +CDKN1B,Deletion,Oncogenic,Loss-of-function,"8646779, 23460367, 18073348, 21422114", +CDKN1B,G9R,Likely Oncogenic,Loss-of-function,21289244, +CDKN1B,P133T,Likely Oncogenic,Likely Loss-of-function,21289244, +CDKN1B,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,"23555276, 8646779, 22129891, 21423803, 20492666, 25416039", +CDKN1B,V109G,Inconclusive,Inconclusive,"22823061, 23652671", +CDKN2A,P114L,Oncogenic,Loss-of-function,"19260062, 8755727", +CDKN2A,M53I,Oncogenic,Loss-of-function,"20340136, 19260062", +CDKN2A,G93W,Likely Oncogenic,Loss-of-function,7647780, +CDKN2A,S56I,Oncogenic,Loss-of-function,20340136, +CDKN2A,I49S,Oncogenic,Loss-of-function,20340136, +CDKN2A,L97R,Oncogenic,Loss-of-function,"20340136, 19260062", +CDKN2A,T77P,Oncogenic,Loss-of-function,19260062, +CDKN2A,D84N,Likely Oncogenic,Loss-of-function,"8755727, 7777061, 10498896", +CDKN2A,P81T,Oncogenic,Loss-of-function,"20340136, 19260062, 10389768", +CDKN2A,L16P,Oncogenic,Loss-of-function,20340136, +CDKN2A,L32P,Oncogenic,Loss-of-function,20340136, +CDKN2A,A36P,Oncogenic,Loss-of-function,20340136, +CDKN2A,Deletion,Oncogenic,Loss-of-function,"24071852, 9516223", +CDKN2A,R99P,Oncogenic,Loss-of-function,"20340136, 19260062", +CDKN2A,G23D,Oncogenic,Loss-of-function,"20340136, 19260062", +CDKN2A,G35V,Likely Oncogenic,Loss-of-function,"20340136, 19260062", +CDKN2A,G35R,Likely Oncogenic,Loss-of-function,"20340136, 19260062", +CDKN2A,P48L,Oncogenic,Loss-of-function,10491434, +CDKN2A,R80P,Likely Oncogenic,Likely Loss-of-function,10491434, +CDKN2A,A60V,Likely Oncogenic,Loss-of-function,"20340136, 19260062", +CDKN2A,D84V,Oncogenic,Loss-of-function,10491434, +CDKN2A,R79P,Oncogenic,Loss-of-function,7647780, +CDKN2A,A148T,Inconclusive,Inconclusive,"15879498, 8603820, 7647780", +CDKN2A,P81L,Oncogenic,Loss-of-function,"20340136, 19260062, 10389768", +CDKN2A,E69G,Oncogenic,Loss-of-function,"20340136, 19260062", +CDKN2A,P114S,Oncogenic,Loss-of-function,"19260062, 8755727", +CDKN2A,D74Y,Likely Oncogenic,Loss-of-function,"10491434, 19260062", +CDKN2A,R24P,Oncogenic,Loss-of-function,20340136, +CDKN2A,V126D,Oncogenic,Loss-of-function,20340136, +CDKN2A,N71S,Oncogenic,Loss-of-function,10491434, +CDKN2A,R87L,Oncogenic,Loss-of-function,"10491434, 9607312", +CDKN2A,H83Y,Oncogenic,Loss-of-function,"10491434, 9324288", +CDKN2A,V118D,Oncogenic,Loss-of-function,7647780, +CDKN2A,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,"20340136, 9324288, 8603820", +CDKN2A,G67S,Oncogenic,Loss-of-function,"20340136, 19260062", +CDKN2A,Q50P,Oncogenic,Loss-of-function,14508519, +CDKN2A,R80L,Oncogenic,Loss-of-function,10491434, +CDKN2A,G35A,Likely Oncogenic,Loss-of-function,"20340136, 19260062", +CDKN2A,A57V,Oncogenic,Loss-of-function,19260062, +CDKN2A,R112G,Oncogenic,Loss-of-function,20340136, +CDKN2A,R87W,Oncogenic,Loss-of-function,"10491434, 19260062", +CDKN2A,E88K,Oncogenic,Loss-of-function,10498896, +CDKN2A,P73L,Oncogenic,Loss-of-function,7647780, +CDKN2A,D74N,Oncogenic,Loss-of-function,"10491434, 19260062", +CDKN2A,N71I,Oncogenic,Loss-of-function,20340136, +CDKN2A,A68T,Oncogenic,Loss-of-function,20340136, +CDKN2A,D84G,Oncogenic,Loss-of-function,10491434, +CDKN2A,H83N,Likely Oncogenic,Loss-of-function,9660926, +CDKN2A,R87P,Oncogenic,Loss-of-function,"10491434, 19260062, 9607312", +CDKN2A,G101W,Oncogenic,Loss-of-function,"10491434, 20340136, 19260062, 8755727", +CDKN2A,D84Y,Oncogenic,Loss-of-function,10498896, +CDKN2A,D108H,Likely Oncogenic,Likely Loss-of-function,12606942, +CDKN2A,D108N,Likely Oncogenic,Likely Loss-of-function,12417717, +CDKN2A,G67R,Oncogenic,Loss-of-function,"20340136, 19260062", +CDKN2A,A60R,Oncogenic,Loss-of-function,"20340136, 19260062", +CDKN2A,D84H,Likely Oncogenic,Loss-of-function,"8755727, 10498896", +CDKN2A,Q50*,Oncogenic,Loss-of-function,7987387, +CDKN2A,N71K,Oncogenic,Loss-of-function,20340136, +CDKN2B,Hypermethylation,Oncogenic,Loss-of-function,"19064397, 17489980", +CDKN2B,D86N,Oncogenic,Loss-of-function,"23715670, 25873077", +CDKN2B,Deletion,Oncogenic,Loss-of-function,"12032783, 8078588, 9479825", +CDKN2B,E35*,Oncogenic,Loss-of-function,25873077, +CDKN2B,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,"12032783, 9479825, 11485924", +CDKN2B,P40T,Oncogenic,Loss-of-function,25873077, +CDKN2B,A23E,Oncogenic,Loss-of-function,25873077, +CDKN2C,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,"19411068, 11124804, 21163929, 16864777, 23616356, 22133722, 25576899, 22997239, 17409423, 16960149, 9528803, 18829482, 18381405, 11485924", +CDKN2C,Deletion,Likely Oncogenic,Likely Loss-of-function,"18829482, 21994415", +ASXL1,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,"19388938, 24216483, 22897849, 21455215, 26095772", +ASXL1,Deletion,Likely Oncogenic,Likely Loss-of-function,"24255920, 22897849, 24218140", +ERBB2,P780L,Likely Oncogenic,Likely Gain-of-function,18413839, +ERBB2,K753E,Inconclusive,Inconclusive,27697991, +ERBB2,C311R,Oncogenic,Gain-of-function,"22908275, 18772890", +ERBB2,T798M,Likely Oncogenic,Likely Gain-of-function,22046346, +ERBB2,D769A,Likely Neutral,Loss-of-function,23843458, +ERBB2,G776delinsLC,Oncogenic,Gain-of-function,26545934, +ERBB2,S310F,Oncogenic,Gain-of-function,"24516025, 24997986, 22908275, 26358791", +ERBB2,G776S,Likely Oncogenic,Gain-of-function,18039657, +ERBB2,G309A,Oncogenic,Gain-of-function,"23220880, 22908275", +ERBB2,D277H,Likely Oncogenic,Likely Gain-of-function,24971884, +ERBB2,I767M,Oncogenic,Gain-of-function,"25994018, 23220880", +ERBB2,L49H,Likely Neutral,Likely Neutral,"22908275, 18772396, 18772890, 23389443", +ERBB2,D277Y,Likely Neutral,Likely Neutral,,"Offin, et al. Abstract# e23150, ASCO 2017 http://abstracts.asco.org/199/AbstView_199_190816.html" +ERBB2,V773A,Likely Oncogenic,Likely Gain-of-function,"22046346, 26619011, 16299242", +ERBB2,D808N,Likely Oncogenic,Likely Gain-of-function,25435280, +ERBB2,Y803N,Inconclusive,Inconclusive,18413839, +ERBB2,C334S,Oncogenic,Gain-of-function,"22908275, 18772890", +ERBB2,D821N,Likely Oncogenic,Likely Gain-of-function,18413839, +ERBB2,L785F,Inconclusive,Inconclusive,18413839, +ERBB2,S1002R,Inconclusive,Inconclusive,18413839, +ERBB2,D769Y,Oncogenic,Gain-of-function,23220880, +ERBB2,T216S,Likely Neutral,Likely Neutral,"22908275, 18772396, 18772890", +ERBB2,S783P,Inconclusive,Inconclusive,18413839, +ERBB2,Amplification,Oncogenic,Gain-of-function,"23204226, 12124352, 2885917, 24656976, 10716706, 11571643", +ERBB2,Y1248F,Likely Neutral,Loss-of-function,1671296, +ERBB2,D845A,Likely Neutral,Loss-of-function,22908275, +ERBB2,C630Y,Inconclusive,Inconclusive,18413839, +ERBB2,V839G,Inconclusive,Inconclusive,18413839, +ERBB2,R896C,Oncogenic,Gain-of-function,23220880, +ERBB2,V794M,Likely Oncogenic,Likely Gain-of-function,25435280, +ERBB2,K753A,Likely Neutral,Loss-of-function,"22393464, 23680147", +ERBB2,K753M,Likely Neutral,Loss-of-function,16489002, +ERBB2,T862A,Oncogenic,Gain-of-function,22046346, +ERBB2,E812K,Inconclusive,Inconclusive,18413839, +ERBB2,Y835F,Likely Neutral,Likely Loss-of-function,23220880, +ERBB2,N319D,Likely Neutral,Likely Neutral,"22908275, 18772396, 18772890, 23389443", +ERBB2,V777A,Likely Oncogenic,Likely Gain-of-function,"26619011, 22908275, 18772396, 18772890, 23389443", +ERBB2,G776_V777insYVMA,Oncogenic,Gain-of-function,16843263, +ERBB2,T733I,Likely Oncogenic,Likely Gain-of-function,"18413839, 16397024", +ERBB2,Exon 20 insertions,Oncogenic,Gain-of-function,"16775247, 23220880, 16843263, 23610105, 21353324, 22649146, 22325357, 25899785", +ERBB2,R678Q,Likely Oncogenic,Likely Gain-of-function,"24971884, 23220880", +ERBB2,L726I,Likely Oncogenic,Gain-of-function,17638894, +ERBB2,R143Q,Likely Neutral,Likely Neutral,24971884, +ERBB2,G660D,Likely Oncogenic,Gain-of-function,"24317180, 26545934", +ERBB2,V659E,Oncogenic,Gain-of-function,"1671296, 7821711", +ERBB2,S310Y,Oncogenic,Gain-of-function,"24516025, 24997986, 22908275, 26358791", +ERBB2,G776delinsVC,Oncogenic,Gain-of-function,26545934, +ERBB2,L755P,Oncogenic,Gain-of-function,22046346, +ERBB2,G778_P780dup,Oncogenic,Gain-of-function,23220880, +ERBB2,E265K,Likely Oncogenic,Likely Gain-of-function,24997986, +ERBB2,L755_T759del,Oncogenic,Gain-of-function,"23220880, 15118073, 15329413, 15118125", +ERBB2,S653C,Oncogenic,Gain-of-function,24971884, +ERBB2,A775_G776insYVMA,Oncogenic,Gain-of-function,17311002, +ERBB2,G292R,Likely Oncogenic,Likely Gain-of-function,24997986, +ERBB2,T798I,Likely Oncogenic,Switch-of-function,"18413839, 28274957", +ERBB2,L866M,Oncogenic,Gain-of-function,26243863, +ERBB2,V777M,Likely Neutral,Likely Neutral,"18039657, 25720673", +ERBB2,N857S,Likely Oncogenic,Likely Gain-of-function,22046346, +ERBB2,S335C,Likely Oncogenic,Likely Gain-of-function,23630663, +ERBB2,E717K,Inconclusive,Inconclusive,18413839, +ERBB2,S760A,Likely Neutral,Likely Neutral,23220880, +ERBB2,G309E,Oncogenic,Gain-of-function,22908275, +ERBB2,H878Y,Likely Oncogenic,Gain-of-function,"22046346, 25853726", +ERBB2,D326G,Likely Neutral,Neutral,22908275, +ERBB2,E321G,Oncogenic,Gain-of-function,"22908275, 18772890", +ERBB2,M774_A775insAYVM,Oncogenic,Gain-of-function,17311002, +ERBB2,D769H,Oncogenic,Gain-of-function,"23220880, 23843458", +ERBB2,V750E,Likely Neutral,Likely Neutral,"22908275, 18772396, 18772890, 23389443", +ERBB2,L869R,Oncogenic,Gain-of-function,"21531810, 26305917, 16397024, 28274957","Hyman et al. Abstract# PD5-05, AACR 2016 http://cancerres.aacrjournals.org/content/76/4_Supplement/PD5-05" +ERBB2,L755S,Oncogenic,Gain-of-function,"22046346, 18413839, 23220880", +ERBB2,Y772_A775dup,Oncogenic,Gain-of-function,"23220880, 16843263, 22908275", +ERBB2,Exon 20 insertions/deletions,Oncogenic,Gain-of-function,"16775247, 23220880, 16843263, 23610105, 21353324, 22649146, 22325357, 25899785", +ERBB2,L726F,Likely Oncogenic,Likely Gain-of-function,"18413839, 25435280", +ERBB2,E719K,Inconclusive,Inconclusive,18413839, +ERBB2,E719G,Inconclusive,Inconclusive,18413839, +ERBB2,L915M,Inconclusive,Inconclusive,18413839, +ERBB2,V777L,Oncogenic,Gain-of-function,"24516025, 22046346, 23220880", +ERBB2,V842I,Oncogenic,Gain-of-function,"24997986, 23220880", +ERBB3,G284R,Oncogenic,Gain-of-function,23680147, +ERBB3,T389K,Oncogenic,Gain-of-function,23680147, +ERBB3,A1131T,Inconclusive,Inconclusive,23741632, +ERBB3,A232V,Oncogenic,Gain-of-function,23680147, +ERBB3,R669C,Inconclusive,Inconclusive,23741632, +ERBB3,V104L,Oncogenic,Gain-of-function,23680147, +ERBB3,V104M,Oncogenic,Gain-of-function,23680147, +ERBB3,V714M,Likely Neutral,Likely Neutral,23680147, +ERBB3,E928G,Oncogenic,Gain-of-function,23680147, +ERBB3,R103G,Likely Oncogenic,Inconclusive,27044931, +ERBB3,P262H,Oncogenic,Gain-of-function,23680147, +ERBB3,S846I,Oncogenic,Gain-of-function,23680147, +ERBB3,Amplification,Oncogenic,Gain-of-function,"20418034, 24886126, 25739551", +ERBB3,Q809R,Oncogenic,Gain-of-function,23680147, +ERBB4,G785S,Inconclusive,Inconclusive,25435280, +ERBB4,K935I,Oncogenic,Gain-of-function,26050618, +ERBB4,G936R,Inconclusive,Inconclusive,21701703, +ERBB4,EZR-ERBB4 Fusion,Oncogenic,Gain-of-function,"24727320, 22327623", +ERBB4,T244R,Likely Neutral,Neutral,26050618, +ERBB4,D843N,Likely Neutral,Loss-of-function,20022944, +ERBB4,T926M,Likely Neutral,Neutral,19098003, +ERBB4,S303F,Inconclusive,Inconclusive,"22908275, 27135912", +ERBB4,D595V,Oncogenic,Gain-of-function,26050618, +ERBB4,R1275W,Oncogenic,Loss-of-function,24119685, +ERBB4,N181S,Likely Neutral,Neutral,26050618, +ERBB4,R306S,Likely Oncogenic,Gain-of-function,26050618, +ERBB4,E542K,Oncogenic,Gain-of-function,19718025, +ERBB4,H618P,Likely Neutral,Neutral,26050618, +ERBB4,E872K,Oncogenic,Gain-of-function,19718025, +ERBB4,E563K,Oncogenic,Gain-of-function,19718025, +ERBB4,R838Q,Inconclusive,Inconclusive,25435280, +ERBB4,E836K,Oncogenic,Gain-of-function,19718025, +ERBB4,Fusions,Likely Oncogenic,Likely Gain-of-function,24727320, +ERBB4,E452K,Oncogenic,Gain-of-function,19718025, +ERBB4,E317K,Oncogenic,Gain-of-function,19718025, +ERBB4,Y285C,Oncogenic,Gain-of-function,26050618, +ERBB4,M887I,Inconclusive,Inconclusive,25435280, +ERBB4,V348L,Likely Neutral,Neutral,26050618, +ERBB4,D931Y,Likely Oncogenic,Gain-of-function,26050618, +ERBB4,R544W,Oncogenic,Gain-of-function,19718025, +ERBB4,S303Y,Inconclusive,Inconclusive,"22908275, 27135912", +ERCC2,N238S,Likely Oncogenic,Likely Loss-of-function,25096233, +ERCC2,F568fs,Likely Oncogenic,Likely Loss-of-function,27504877, +ERCC2,D513Y,Likely Oncogenic,Likely Loss-of-function,27504877, +ERCC2,P463L,Likely Oncogenic,Likely Loss-of-function,25096233, +ERCC2,R592H,Likely Neutral,Likely Neutral,27504877, +ERCC2,Y24C,Likely Oncogenic,Likely Loss-of-function,25096233, +ERCC2,R450H,Likely Neutral,Likely Neutral,27504877, +ERCC2,D609G,Likely Oncogenic,Likely Loss-of-function,25096233, +ERCC2,L461V,Likely Oncogenic,Likely Loss-of-function,27504877, +ERCC2,E606G,Likely Oncogenic,Likely Loss-of-function,25096233, +ERCC2,R601Q,Likely Oncogenic,Likely Loss-of-function,27504877, +ERCC2,D609E,Likely Oncogenic,Likely Loss-of-function,25096233, +ERCC2,S746fs,Likely Oncogenic,Likely Loss-of-function,27504877, +ERCC2,G665A,Likely Oncogenic,Likely Loss-of-function,25096233, +ERCC2,R631C,Likely Oncogenic,Likely Loss-of-function,27504877, +ERCC2,V536M,Likely Oncogenic,Likely Loss-of-function,27504877, +ERCC2,Amplification,Likely Oncogenic,Likely Gain-of-function,25096233, +ERCC2,R487W,Likely Oncogenic,Likely Loss-of-function,27504877, +ERCC2,V242F,Likely Oncogenic,Likely Loss-of-function,25096233, +ERCC2,D423N,Likely Oncogenic,Likely Loss-of-function,27504877, +ERCC2,A717G,Likely Oncogenic,Likely Loss-of-function,27504877, +BRIP1,M299I,Inconclusive,Inconclusive,"17145708, 11301010, 14983014", +BRIP1,Deletion,Likely Oncogenic,Likely Loss-of-function,"24040146, 21964575, 18628483", +BRIP1,R173C,Oncogenic,Loss-of-function,12569564, +BRIP1,K52R,Oncogenic,Loss-of-function,"11301010, 2846277, 8196650, 14983014", +BRIP1,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,"16153896, 24040146, 17033622, 21964575, 18628483", +BRIP1,A349P,Likely Oncogenic,Likely Loss-of-function,"20639400, 16116424", +BRIP1,P47A,Oncogenic,Loss-of-function,"11301010, 14983014", +BRIP1,R798*,Likely Oncogenic,Likely Loss-of-function,"16153896, 17033622", +ERCC3,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,"16143348, 19942596, 27655433, 8196650", +ERCC3,R109*,Likely Oncogenic,Loss-of-function,27655433, +ERCC4,Deletion,Likely Oncogenic,Likely Loss-of-function,"9580660, 26074087, 23623386", +ERCC4,R689S,Oncogenic,Loss-of-function,"24027083, 23623386", +ERCC4,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,"9580660, 8887684", +ERCC4,L230P,Oncogenic,Loss-of-function,23623386, +ERCC4,E875G,Oncogenic,Loss-of-function,10499592, +ERCC4,S786F,Oncogenic,Loss-of-function,24027083, +ABL1,E279K,Likely Oncogenic,Likely Gain-of-function,21562040, +ABL1,H396P,Likely Oncogenic,Likely Gain-of-function,"21562040, 16424036", +ABL1,L248V,Likely Oncogenic,Likely Gain-of-function,21562040, +ABL1,D276G,Oncogenic,Gain-of-function,15510211, +ABL1,V289F,Likely Oncogenic,Likely Gain-of-function,23355941, +ABL1,F317L,Likely Oncogenic,Likely Gain-of-function,21562040, +ABL1,L387M,Likely Oncogenic,Likely Gain-of-function,21562040, +ABL1,M351T,Likely Oncogenic,Likely Gain-of-function,"16046538, 21562040", +ABL1,F311L,Likely Oncogenic,Likely Gain-of-function,21562040, +ABL1,G250E,Likely Oncogenic,Likely Gain-of-function,21562040, +ABL1,E355A,Likely Oncogenic,Likely Gain-of-function,24456693, +ABL1,V379I,Likely Oncogenic,Likely Gain-of-function,21562040, +ABL1,H396R,Likely Oncogenic,Likely Gain-of-function,21562040, +ABL1,M244V,Likely Oncogenic,Likely Gain-of-function,21562040, +ABL1,F359V,Likely Oncogenic,Likely Gain-of-function,21562040, +ABL1,Q252H,Likely Oncogenic,Likely Gain-of-function,"16046538, 21562040", +ABL1,Y253F,Oncogenic,Gain-of-function,16880519, +ABL1,E355G,Likely Oncogenic,Likely Gain-of-function,21562040, +ABL1,E459K,Likely Oncogenic,Likely Gain-of-function,19201023, +ABL1,E281K,Likely Oncogenic,Likely Gain-of-function,21193419, +ABL1,L384M,Likely Oncogenic,Likely Gain-of-function,21562040, +ABL1,E255K,Likely Oncogenic,Likely Gain-of-function,15194504, +ABL1,V299L,Likely Oncogenic,Likely Gain-of-function,"23086624, 18242697", +ABL1,F359C,Likely Oncogenic,Likely Gain-of-function,19798095, +ABL1,T315I,Likely Oncogenic,Likely Gain-of-function,"18794843, 11423618", +ABL1,Fusions,Likely Oncogenic,Likely Gain-of-function,21435002, +ABL1,Y253H,Likely Oncogenic,Likely Gain-of-function,16482207, +ABL1,BCR-ABL1 Fusion,Oncogenic,Gain-of-function,"11345193, 18851712", +ABL1,E255V,Likely Oncogenic,Likely Gain-of-function,21562040, +CEBPA,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,"11830484, 19322763, 19651529, 18768433, 19075268", +ERF,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,"21548782, 17699159, 17525531, 22198386", +ERG,FUS-ERG Fusion,Oncogenic,Gain-of-function,"8187069, 7970732, 9653171, 25453903", +ERG,TMPRSS2-ERG Fusion,Oncogenic,Gain-of-function,"22142399, 19396167, 18283340, 17043636", +ERG,EWSR1-ERG Fusion,Oncogenic,Gain-of-function,"16357154, 8162068, 25453903", +ERG,Fusions,Likely Oncogenic,Likely Gain-of-function,"19649210, 23625457, 20585344", +HLA-A,596_619splice,Likely Oncogenic,Likely Loss-of-function,16216676, +HLA-A,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,15546342, +HLA-B,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,"26889905, 19845903, 27807939, 14675390, 28205408", +PDGFRA,D846Y,Likely Oncogenic,Gain-of-function,"15928335, 22745105", +PDGFRA,C456_R481del,Oncogenic,Gain-of-function,23970477, +PDGFRA,D842Y,Likely Oncogenic,Gain-of-function,"15928335, 24132921, 22745105", +PDGFRA,N659S,Likely Oncogenic,Gain-of-function,21224473, +PDGFRA,A633T,Likely Oncogenic,Likely Gain-of-function,24132921, +PDGFRA,Y849S,Likely Oncogenic,Gain-of-function,21224473, +PDGFRA,V658A,Likely Oncogenic,Gain-of-function,24132921, +PDGFRA,I843del,Likely Oncogenic,Gain-of-function,22745105, +PDGFRA,BCR-PDGFRA Fusion,Likely Oncogenic,Gain-of-function,"12023981, 12944919, 15034867", +PDGFRA,G853D,Oncogenic,Gain-of-function,24132921, +PDGFRA,L507P,Likely Neutral,Likely Neutral,"24057647, 21224473", +PDGFRA,N659K,Likely Oncogenic,Gain-of-function,15928335, +PDGFRA,ETV6-PDGFRA Fusion,Oncogenic,Gain-of-function,17555450, +PDGFRA,A633V,Likely Neutral,Neutral,24132921, +PDGFRA,H570R,Likely Neutral,Neutral,21224473, +PDGFRA,C450_K451insMIEWMI,Oncogenic,Gain-of-function,23970477, +PDGFRA,R748G,Oncogenic,Gain-of-function,21224473, +PDGFRA,I562M,Likely Neutral,Neutral,21224473, +PDGFRA,KIF5B-PDGFRA Fusion,Oncogenic,Gain-of-function,"17555450, 16498388", +PDGFRA,E311_K312del,Oncogenic,Gain-of-function,23970477, +PDGFRA,Fusions,Likely Oncogenic,Likely Gain-of-function,20889717, +PDGFRA,W349C,Likely Neutral,Likely Loss-of-function,23752188, +PDGFRA,V469A,Likely Oncogenic,Likely Gain-of-function,23752188, +PDGFRA,D842V,Oncogenic,Gain-of-function,"24132921, 22665524, 23752188, 18794084, 17087936, 12949711, 15928335, 23970477, 19217431, 12522257, 18955458, 22745105, 15685537, 16030188", +PDGFRA,FIP1L1-PDGFRA Fusion,Oncogenic,Gain-of-function,"16754777, 19187542, 16645167, 24057647, 12660384, 16690743, 24407160, 16608506, 21224473, 19212337, 12781364, 27021554, 16030188", +PDGFRA,V536E,Oncogenic,Gain-of-function,23752188, +PDGFRA,Y849C,Likely Oncogenic,Gain-of-function,"15146165, 15928335", +PDGFRA,N659R,Likely Oncogenic,Gain-of-function,15928335, +PDGFRA,CDK5RAP2-PDGFRA Fusion,Oncogenic,Gain-of-function,16845659, +PDGFRA,H845Y,Likely Oncogenic,Gain-of-function,24132921, +PDGFRA,V544_L545insAVLVLLVIVIISLI,Oncogenic,Gain-of-function,23970477, +PDGFRA,V561A,Oncogenic,Likely Gain-of-function,24132921, +PDGFRA,N848K,Likely Oncogenic,Gain-of-function,15928335, +PDGFRA,R481G,Likely Neutral,Likely Neutral,21224473, +PDGFRA,S478P,Likely Neutral,Likely Neutral,"22733151, 12949711, 19366796", +PDGFRA,F808L,Likely Neutral,Loss-of-function,23752188, +PDGFRA,V561_I562insER,Oncogenic,Gain-of-function,"15928335, 12522257", +PDGFRA,D842_H845del,Likely Oncogenic,Gain-of-function,22745105, +PDGFRA,W559_R560del,Oncogenic,Gain-of-function,26396737, +PDGFRA,Y375_K455del,Oncogenic,Gain-of-function,"20889717, 12569364", +PDGFRA,D568N,Likely Oncogenic,Gain-of-function,24132921, +PDGFRA,Amplification,Oncogenic,Gain-of-function,"21931021, 20685895, 18772890, 22745105, 16357008", +PDGFRA,H650Q,Oncogenic,Gain-of-function,21224473, +PDGFRA,P130S,Likely Neutral,Likely Neutral,23752188, +PDGFRA,D842_M844del,Likely Oncogenic,Gain-of-function,18794084, +PDGFRA,I834V,Likely Neutral,Neutral,24132921, +PDGFRA,I843_D846del,Likely Oncogenic,Gain-of-function,"18955458, 22745105", +PDGFRA,D842I,Likely Oncogenic,Gain-of-function,"15928335, 22745105", +PDGFRA,S584L,Likely Oncogenic,Gain-of-function,24132921, +PDGFRA,Q579R,Likely Oncogenic,Gain-of-function,24132921, +PDGFRA,Y555C,Likely Oncogenic,Gain-of-function,"25975287, 17087943", +PDGFRA,K830R,Likely Neutral,Neutral,24132921, +PDGFRA,V561D,Oncogenic,Gain-of-function,"17087936, 12949711, 15928335, 19217431, 12522257, 18955458, 22665524, 22745105", +PDGFRA,C456_N468del,Oncogenic,Gain-of-function,23970477, +PDGFRA,T674I,Likely Oncogenic,Likely Gain-of-function,22745105, +PDGFRA,N870S,Likely Neutral,Neutral,23752188, +PDGFRA,S566_E571delinsR,Likely Oncogenic,Gain-of-function,"15928335, 12522257", +PDGFRA,R560_V561insER,Oncogenic,Gain-of-function,22745105, +PDGFRA,KDR-PDGFRA Fusion,Oncogenic,Gain-of-function,"20889717, 16690743", +PDGFRA,P577S,Likely Oncogenic,Gain-of-function,24132921, +PDGFRA,E996K,Likely Neutral,Neutral,23752188, +PDGFRA,D1071N,Likely Neutral,Neutral,23752188, +PDGFRA,G829R,Likely Neutral,Neutral,23752188, +PDGFRA,H845_N848delinsP,Oncogenic,Gain-of-function,"15928335, 12522257, 22745105", +PDGFRA,D842_I843delinsIM,Oncogenic,Gain-of-function,"15928335, 22745105", +PDGFRA,R841K,Oncogenic,Gain-of-function,24132921, +PDGFRA,STRN-PDGFRA Fusion,Oncogenic,Gain-of-function,17555450, +PDGFRB,L658P,Likely Neutral,Loss-of-function,"23255827, 26599395", +PDGFRB,P660T,Inconclusive,Inconclusive,23731542, +PDGFRB,Fusions,Likely Oncogenic,Likely Gain-of-function,"20581310, 8962143, 19806146, 22271894, 8168137, 22897847, 18483217", +PDGFRB,NIN-PDGFRB Fusion,Likely Oncogenic,Likely Gain-of-function,15087377, +PDGFRB,V665A,Oncogenic,Loss-of-function,26279204, +PDGFRB,E1071W,Likely Neutral,Likely Loss-of-function,"23255827, 26599395", +PDGFRB,BIN2-PDGFRB Fusion,Likely Oncogenic,Likely Gain-of-function,20085582, +PDGFRB,ATF7IP-PDGFRB Fusion,Likely Oncogenic,Likely Gain-of-function,8168137, +PDGFRB,WDR48-PDGFRB Fusion,Likely Oncogenic,Likely Gain-of-function,20085582, +PDGFRB,PDE4DIP-PDGFRB Fusion,Likely Oncogenic,Likely Gain-of-function,12907457, +PDGFRB,RABEP1-PDGFRB Fusion,Oncogenic,Gain-of-function,11588050, +PDGFRB,KANK1-PDGFRB Fusion,Oncogenic,Gain-of-function,21685469, +PDGFRB,KIAA1509-PDGFRB Fusion,Likely Oncogenic,Likely Gain-of-function,12907457, +PDGFRB,HIP1-PDGFRB Fusion,Oncogenic,Gain-of-function,9616134, +PDGFRB,Amplification,Inconclusive,Inconclusive,"18515258, 18157090, 18612157, 16630177, 21729646, 18670317", +PDGFRB,GPIAP1-PDGFRB Fusion,Likely Oncogenic,Likely Gain-of-function,17296564, +PDGFRB,R987W,Likely Neutral,Likely Loss-of-function,"23255827, 26599395", +PDGFRB,SPTBN1-PDGFRB Fusion,Likely Oncogenic,Likely Gain-of-function,18262053, +PDGFRB,TP53BP1-PDGFRB Fusion,Likely Oncogenic,Likely Gain-of-function,15492236, +PDGFRB,ETV6-PDGFRB Fusion,Oncogenic,Gain-of-function,"22271894, 8168137, 19644140, 19100521", +PDGFRB,R561C,Inconclusive,Inconclusive,23731537, +PDGFRB,GIT2-PDGFRB Fusion,Likely Oncogenic,Likely Gain-of-function,"17296564, 18262053", +PDGFRB,GOLGA4-PDGFRB Fusion,Likely Oncogenic,Likely Gain-of-function,20085582, +PDGFRB,EBF1-PDGFRB Fusion,Oncogenic,Gain-of-function,"24186319, 8168137, 22897847, 23835704", +PDGFRB,PRKG2-PDGFRB Fusion,Likely Oncogenic,Likely Gain-of-function,"17296564, 18262053", +PDGFRB,CEP85L-PDGFRB Fusion,Oncogenic,Likely Gain-of-function,"23186533, 15492236", +RBM10,V354E,Oncogenic,Loss-of-function,"20007775, 24332178", +RBM10,Deletion,Likely Oncogenic,Likely Loss-of-function,"26853560, 24000153, 24332178", +RBM10,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,"21910224, 24000153, 22980975, 25079552, 24332178", +KDM5C,D402Y,Likely Oncogenic,Loss-of-function,25666439, +KDM5C,Overexpression,Likely Oncogenic,Likely Gain-of-function,25016185, +KDM5C,P480L,Likely Oncogenic,Loss-of-function,25666439, +KDM5C,V1075Yfs*2,Likely Oncogenic,Loss-of-function,25666439, +KDM5C,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,"20133580, 22138691, 15586325, 23356856, 21725364, 25712104, 24166983, 21544224, 25111482, 20054297, 20181063", +KDM5C,M1_E165DEL,Likely Oncogenic,Loss-of-function,25666439, +ESR1,Y537N,Likely Oncogenic,Gain-of-function,"24185512, 24398047, 24185510, 9102207, 11322512, 9500442", +ESR1,L536H,Likely Oncogenic,Gain-of-function,"1630819, 15282324, 15159406", +ESR1,L536Q,Likely Oncogenic,Gain-of-function,"24185510, 1630819, 15282324", +ESR1,Y537S,Oncogenic,Gain-of-function,"24185512, 24185510, 26836308, 27986707, 8923465, 9398213, 11914066", +ESR1,L536P,Likely Oncogenic,Gain-of-function,"10787412, 9234721, 1630819, 9774463, 15282324", +ESR1,S463P,Likely Oncogenic,Likely Gain-of-function,"24185512, 1630819, 15282324", +ESR1,ESR1-YAP1 Fusion,Oncogenic,Gain-of-function,24055055, +ESR1,D538G,Oncogenic,Gain-of-function,"24185512, 24398047, 24185510, 24217577, 1630819, 26836308, 15282324", +ESR1,V534E,Likely Neutral,Likely Neutral,27986707, +ESR1,Fusions,Likely Oncogenic,Likely Gain-of-function,"25099679, 24055055", +ESR1,S432L,Likely Neutral,Likely Neutral,27986707, +ESR1,V422del,Likely Oncogenic,Gain-of-function,27986707, +ESR1,E380Q,Likely Oncogenic,Gain-of-function,"9259327, 1630819, 8114756, 15282324", +ESR1,L536R,Likely Oncogenic,Gain-of-function,"24185512, 1630819, 15282324", +ESR1,ESR1-CCDC170 Fusion,Oncogenic,Gain-of-function,"25099679, 22496636, 22101766", +ESR1,Y537C,Likely Oncogenic,Gain-of-function,"24398047, 24185510, 1630819, 11322512, 9500442, 15282324", +ESR1,L469V,Likely Oncogenic,Gain-of-function,"1630819, 27986707, 15282324", +ETV1,EWSR1-ETV1 Fusion,Oncogenic,Gain-of-function,"16357154, 7700648, 25453903", +ETV1,Amplification,Oncogenic,Gain-of-function,"23908683, 20160028", +ETV1,TMPRSS2-ETV1 Fusion,Oncogenic,Gain-of-function,"18563191, 23512661", +ETV1,Fusions,Likely Oncogenic,Likely Gain-of-function,"23814484, 21298110, 18794142, 23625457, 17671502", +ETV6,ETV6-NTRK3 Fusion,Oncogenic,Gain-of-function,"21804605, 18068631, 21148487", +ETV6,ETV6-FLT3 Fusion,Oncogenic,Gain-of-function,16761019, +ETV6,R369W,Likely Oncogenic,Likely Loss-of-function,"25581430, 26522332, 27365488", +ETV6,385_418del,Likely Oncogenic,Loss-of-function,25807284, +ETV6,Fusions,Likely Oncogenic,Likely Gain-of-function,"12173038, 10702799, 22578774", +ETV6,R418G,Likely Oncogenic,Loss-of-function,25807284, +ETV6,R369Q,Likely Oncogenic,Likely Loss-of-function,"25581430, 26522332, 26102509, 27365488", +ETV6,P214L,Likely Oncogenic,Loss-of-function,25807284, +TSC1,L180P,Likely Oncogenic,Loss-of-function,18830229, +TSC1,H105R,Likely Oncogenic,Loss-of-function,18397877, +TSC1,V220F,Likely Oncogenic,Likely Loss-of-function,22923433, +TSC1,S35Q,Likely Oncogenic,Loss-of-function,18397877, +TSC1,Deletion,Likely Oncogenic,Likely Loss-of-function,"23485365, 24529379, 11741833, 10353610", +TSC1,F158C,Likely Oncogenic,Loss-of-function,18397877, +TSC1,R1097H,Likely Neutral,Neutral,18830229, +TSC1,M224R,Oncogenic,Loss-of-function,18830229, +TSC1,F216A,Likely Oncogenic,Likely Loss-of-function,18397877, +TSC1,H206D,Likely Oncogenic,Loss-of-function,18397877, +TSC1,R246K,Likely Neutral,Neutral,18830229, +TSC1,G1035S,Likely Neutral,Neutral,18830229, +TSC1,L191H,Likely Oncogenic,Loss-of-function,18830229, +TSC1,N198_F199delinsI,Likely Oncogenic,Loss-of-function,"18830229, 11781698, 17304050", +TSC1,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,"23485365, 24529379, 20301399", +TSC1,K82T,Likely Neutral,Likely Neutral,"23857276, 21309039", +TSC1,L117P,Likely Oncogenic,Loss-of-function,18830229, +TSC1,R509Q,Likely Neutral,Neutral,18830229, +TSC1,H68R,Likely Oncogenic,Likely Loss-of-function,18397877, +TSC1,V128del,Likely Oncogenic,Loss-of-function,18830229, +TSC1,G305W,Likely Neutral,Neutral,18830229, +TSC1,G305R,Likely Neutral,Neutral,18830229, +TSC1,T417I,Likely Neutral,Neutral,"18397877, 10570911, 10607950", +IKZF1,Deletion,Likely Oncogenic,Loss-of-function,"27067989, 19129520, 27815723, 26202931", +TSC2,V1673F,Likely Oncogenic,Likely Loss-of-function,22903760, +TSC2,H597Y,Oncogenic,Loss-of-function,22903760, +TSC2,E75G,Likely Oncogenic,Likely Loss-of-function,"22903760, 27493206", +TSC2,L493V,Likely Oncogenic,Likely Loss-of-function,22903760, +TSC2,L830R,Oncogenic,Loss-of-function,22903760, +TSC2,C696Y,Likely Oncogenic,Loss-of-function,"15483652, 11741832", +TSC2,R505Q,Likely Oncogenic,Likely Loss-of-function,22903760, +TSC2,S1653P,Oncogenic,Loss-of-function,22903760, +TSC2,R1200W,Likely Oncogenic,Loss-of-function,21332470, +TSC2,V241del,Oncogenic,Loss-of-function,22903760, +TSC2,Y598C,Likely Oncogenic,Likely Loss-of-function,22903760, +TSC2,E1552del,Oncogenic,Loss-of-function,22903760, +TSC2,G1596V,Likely Oncogenic,Likely Loss-of-function,22903760, +TSC2,L410R,Oncogenic,Loss-of-function,22903760, +TSC2,T1623I,Oncogenic,Loss-of-function,22903760, +TSC2,R611Q,Likely Oncogenic,Loss-of-function,"15483652, 11741832", +TSC2,P1675L,Likely Oncogenic,Loss-of-function,"11290735, 22903760, 12205112", +TSC2,S1036P,Likely Oncogenic,Likely Loss-of-function,21332470, +TSC2,L1584R,Likely Oncogenic,Likely Loss-of-function,22903760, +TSC2,A889P,Oncogenic,Loss-of-function,22903760, +TSC2,V705E,Oncogenic,Loss-of-function,22903760, +TSC2,W1610G,Likely Oncogenic,Likely Loss-of-function,22903760, +TSC2,L844R,Likely Oncogenic,Likely Loss-of-function,22903760, +TSC2,L146R,Likely Oncogenic,Likely Loss-of-function,22903760, +TSC2,L448P,Likely Oncogenic,Likely Loss-of-function,22903760, +TSC2,V705M,Likely Oncogenic,Loss-of-function,22903760, +TSC2,Y1571N,Oncogenic,Loss-of-function,22903760, +TSC2,R462C,Likely Oncogenic,Likely Loss-of-function,22903760, +TSC2,R905G,Likely Oncogenic,Loss-of-function,17120248, +TSC2,V769E,Likely Oncogenic,Loss-of-function,"15483652, 11741832", +TSC2,R905Q,Likely Oncogenic,Loss-of-function,17120248, +TSC2,V299G,Likely Oncogenic,Likely Loss-of-function,22903760, +TSC2,H1620R,Oncogenic,Loss-of-function,22903760, +TSC2,Q1503P,Likely Oncogenic,Likely Loss-of-function,22903760, +TSC2,Deletion,Oncogenic,Likely Loss-of-function,"11281455, 25724664, 26540169, 25281918, 14561707", +TSC2,L493P,Likely Oncogenic,Gain-of-function,22903760, +TSC2,S1653F,Oncogenic,Loss-of-function,22903760, +TSC2,T1203K,Oncogenic,Loss-of-function,22903760, +TSC2,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,"24529379, 14729330, 25724664, 14561707", +TSC2,R611W,Likely Oncogenic,Loss-of-function,"15483652, 11741832", +TSC2,L826P,Likely Oncogenic,Likely Loss-of-function,"15483652, 22903760", +TSC2,V1673D,Likely Oncogenic,Likely Loss-of-function,22903760, +TSC2,F615S,Likely Oncogenic,Likely Loss-of-function,"15483652, 11741832", +TSC2,P1709L,Likely Oncogenic,Likely Loss-of-function,22903760, +TSC2,I427M,Likely Oncogenic,Likely Loss-of-function,22903760, +TSC2,A328P,Likely Oncogenic,Likely Loss-of-function,22903760, +TSC2,A614D,Likely Oncogenic,Loss-of-function,"15483652, 11741832", +TSC2,R905W,Likely Oncogenic,Loss-of-function,17120248, +TSC2,G1567D,Likely Oncogenic,Likely Loss-of-function,22903760, +TSC2,L792R,Oncogenic,Loss-of-function,22903760, +TSC2,Q1554H,Likely Oncogenic,Likely Loss-of-function,22903760, +TSC2,S1498N,Likely Oncogenic,Likely Loss-of-function,15972957, +EWSR1,EWSR1-FLI1 Fusion,Oncogenic,Gain-of-function,"17250957, 22930730, 24320889, 11715049, 25453903, 12432241", +EWSR1,EWSR1-ETV1 Fusion,Oncogenic,Gain-of-function,25109552, +EWSR1,EWSR1-FEV Fusion,Likely Oncogenic,Likely Gain-of-function,9121764, +EWSR1,EWSR1-ETV4 Fusion,Likely Oncogenic,Likely Gain-of-function,8605035, +EWSR1,EWSR1-ERG Fusion,Oncogenic,Gain-of-function,"18500345, 8162068, 10749119", +EWSR1,EWSR1-ATF1 Fusion,Likely Oncogenic,Likely Gain-of-function,"24320889, 21822206, 25364450, 19801966", +EWSR1,EWSR1-NR4A3 Fusion,Oncogenic,Gain-of-function,"22592656, 16604165", +EWSR1,Fusions,Likely Oncogenic,Likely Gain-of-function,"8605035, 23329308, 21113140, 8834175",NCCN Bone Cancer. Volume# v.2017 https://www.nccn.org/professionals/physician_gls/pdf/bone.pdf +EWSR1,EWSR1-CREB1 Fusion,Likely Oncogenic,Likely Gain-of-function,"24320889, 21822206, 25364450, 19801966", +EWSR1,EWSR1-DDIT3 Fusion,Oncogenic,Gain-of-function,"24320889, 7805034, 24790523", +EWSR1,EWSR1-WT1 Fusion,Oncogenic,Gain-of-function,"9591781, 11278460, 10999739, 11237525, 24321497", +EWSR1,EWSR1-YY1 Fusion,Oncogenic,Gain-of-function,23630070, +ACVR1,G328E,Likely Oncogenic,Likely Gain-of-function,"24705254, 20463014, 22977237, 24769718", +ACVR1,G356D,Likely Oncogenic,Gain-of-function,"20463014, 22977237, 24769718, 18952055", +ACVR1,Q207E,Likely Oncogenic,Likely Gain-of-function,24852373, +ACVR1,R206H,Likely Oncogenic,Gain-of-function,"24705254, 20463014, 22977237, 24769718", +ACVR1,G328V,Likely Oncogenic,Gain-of-function,"24705254, 20463014, 24705250, 24769718", +FOXA1,Deletion,Likely Oncogenic,Likely Loss-of-function,24840332, +FOXA1,G87R,Likely Oncogenic,Likely Loss-of-function,22722839, +FOXA1,F400I,Likely Oncogenic,Likely Loss-of-function,"22722839, 23539448", +FOXA1,L388M,Likely Oncogenic,Likely Loss-of-function,22722839, +FOXA1,Amplification,Oncogenic,Gain-of-function,"22138582, 19470727, 22722839, 21147910, 22960745, 23622249, 19372580, 2298097, 23539448, 25079552, 12234996", +FOXA1,S453fs*,Likely Oncogenic,Likely Gain-of-function,22722839, +FOXA1,L455M,Likely Oncogenic,Likely Loss-of-function,22722839, +FOXA1,M253K,Likely Oncogenic,Likely Loss-of-function,23539448, +MDM2,Amplification,Oncogenic,Gain-of-function,"9671804, 24667108, 15199139, 27194168, 28481359", +ARID1A,Deletion,Likely Oncogenic,Loss-of-function,"22249247, 23097632, 21412130, 23208470", +ARID1A,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,"21900401, 24899687, 25625625", +EZH2,Y646H,Oncogenic,Switch-of-function,"21078963, 21190999", +EZH2,Y646N,Oncogenic,Switch-of-function,"21078963, 21190999, 24469040, 21810159, 21843048", +EZH2,Y646C,Oncogenic,Switch-of-function,"21078963, 21190999", +EZH2,A677G,Likely Oncogenic,Switch-of-function,22323599, +EZH2,Overexpression,Oncogenic,Gain-of-function,"16330673, 12374981, 14500907, 21837672", +EZH2,Y646S,Oncogenic,Switch-of-function,"21078963, 21190999", +EZH2,Amplification,Oncogenic,Gain-of-function,"16330673, 12374981, 14500907, 21837672", +EZH2,Y646F,Oncogenic,Switch-of-function,"21078963, 21190999, 27135738, 24469040, 21810159, 21843048", +MDM4,Amplification,Oncogenic,Gain-of-function,"9523192, 15199139, 7585611", +MDM4,G57A,Oncogenic,Loss-of-function,"15199139, 9131587", +KLF4,K409Q,Likely Oncogenic,Likely Gain-of-function,23404370, +RXRA,S247F,Inconclusive,Inconclusive,24476821, +RXRA,S247Y,Inconclusive,Inconclusive,24476821, +MAP3K1,E1286V,Likely Neutral,Likely Neutral,25899310, +MAP3K1,Truncating Mutations,Likely Oncogenic,Inconclusive,"24003131, 24386504", +MAP3K1,T779fs,Likely Oncogenic,Likely Loss-of-function,25899310, +MAP3K1,T1481fs,Likely Oncogenic,Likely Loss-of-function,25899310, +AXIN1,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,"10700176, 25236910", +AXIN2,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,"15802015, 17373666", +BAP1,E685V,Likely Oncogenic,Loss-of-function,25830670, +BAP1,F81V,Likely Oncogenic,Loss-of-function,26680512, +BAP1,C91S,Oncogenic,Loss-of-function,"19815555, 9528852", +BAP1,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,"21874000, 18757409", +BAP1,C91A,Likely Oncogenic,Loss-of-function,18757409, +BAP1,A95D,Likely Oncogenic,Loss-of-function,"26680512, 24894717, 18757409", +BAP1,G178V,Likely Oncogenic,Loss-of-function,"24894717, 18757409", +BAP1,I47F,Likely Oncogenic,Loss-of-function,26680512, +BAP1,F170I,Likely Oncogenic,Loss-of-function,26081045, +BAP1,Deletion,Likely Oncogenic,Likely Loss-of-function,"21874000, 26246155, 24633195, 25970771", +MEN1,Deletion,Oncogenic,Loss-of-function,"12746426, 27076911, 9510467, 16740708, 21627674, 14633735, 12941803", +MEN1,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,"12746426, 14992727, 9241276, 9766672, 27076911, 9510467, 9361035, 21627674, 9103196", +FANCA,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,"21273304, 15522956, 24689079, 12827451", +FANCA,S1088F,Likely Oncogenic,Likely Loss-of-function,10094191,"Wilkes et al. Molecular Case Studies, 2016 http://molecularcasestudies.cshlp.org/content/early/2017/05/03/mcs.a001487.short" +FANCA,R1055L,Likely Oncogenic,Likely Loss-of-function,16720839, +FANCA,Deletion,Likely Oncogenic,Likely Loss-of-function,"15522956, 12637330, 24689079, 8374893, 12827451, 14749703", +FANCA,S858R,Likely Oncogenic,Loss-of-function,12955722, +FANCA,L210R,Likely Oncogenic,Loss-of-function,16720839, +FANCA,W183A,Likely Oncogenic,Loss-of-function,"10468606, 11050007, 11161829", +FANCA,H492R,Likely Oncogenic,Loss-of-function,"16720839, 12444097", +FANCA,Y510C,Likely Oncogenic,Loss-of-function,16720839, +FANCA,L274P,Likely Oncogenic,Loss-of-function,16720839, +FANCC,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,"11520787, 16687415, 20509860", +MET,Y1235D,Oncogenic,Gain-of-function,"12460923, 10734314", +MET,V1092I,Oncogenic,Gain-of-function,"24061647, 10417759", +MET,H1094L,Oncogenic,Gain-of-function,"19783361, 24061647", +MET,Amplification,Oncogenic,Gain-of-function,"16461907, 20129249, 19117057, 17667909, 22869872, 18077425, 17463250", +MET,Y1003*,Likely Oncogenic,Likely Gain-of-function,"25079552, 16397241", +MET,963_D1010splice,Oncogenic,Gain-of-function,"15735036, 16397241, 19096300", +MET,X1007_splice,Oncogenic,Gain-of-function,"15735036, 16397241, 19096300", +MET,V1188L,Oncogenic,Gain-of-function,"15064724, 24061647", +MET,X1009_splice,Oncogenic,Gain-of-function,"15735036, 16397241, 19096300", +MET,H1094Y,Oncogenic,Gain-of-function,"15064724, 24061647", +MET,X963_splice,Oncogenic,Gain-of-function,"15735036, 16397241, 19096300", +MET,H1094R,Oncogenic,Gain-of-function,9563489, +MET,N1100Y,Oncogenic,Gain-of-function,12460923, +MET,H1106D,Likely Oncogenic,Likely Gain-of-function,10327054, +MET,V1070E,Oncogenic,Gain-of-function,25401301, +MET,PTPRZ1-MET Fusion,Likely Oncogenic,Likely Gain-of-function,25135958, +MET,E168D,Likely Oncogenic,Gain-of-function,19318576,Ma et al. Abstract# 14010 ASCO 2010 http://hwmaint.meeting.ascopubs.org/cgi/content/abstract/25/18_suppl/14010 +MET,D1010H,Likely Oncogenic,Likely Gain-of-function,"27666659, 14559814, 16227611, 25898965, 25971938, 15735036, 27343443, 16397241, 26892698, 19096300", +MET,M1250T,Oncogenic,Gain-of-function,"10327054, 10871851, 9826715, 15557554", +MET,T992I,Likely Oncogenic,Gain-of-function,"25605252, 14559814, 21970370, 11042681, 22973954, 15735036, 17322284", +MET,R970C,Inconclusive,Inconclusive,"20670955, 14559814, 22973954", +MET,F1200I,Oncogenic,Gain-of-function,"24173966, 21697284", +MET,X1006_splice,Oncogenic,Gain-of-function,"15735036, 16397241, 19096300", +MET,N375S,Inconclusive,Inconclusive,"16171945, 19723643", +MET,981_1028splice,Oncogenic,Gain-of-function,"15735036, 16397241, 19096300", +MET,L1195V,Oncogenic,Gain-of-function,"15064724, 24061647", +MET,D1010N,Likely Oncogenic,Likely Gain-of-function,26892698, +MET,Y1230H,Oncogenic,Gain-of-function,"27666659, 9826708, 9326629", +MET,Y1230C,Likely Oncogenic,Gain-of-function,"9826708, 18709663", +MET,Y1003F,Oncogenic,Gain-of-function,"16227611, 15123609, 11741535", +MET,D1010Y,Likely Oncogenic,Likely Gain-of-function,"27666659, 14559814, 16227611, 25898965, 25971938, 15735036, 27343443, 16397241, 19096300", +MET,Overexpression,Oncogenic,Gain-of-function,"9554529, 9870683, 8077049, 11381087, 15375530, 10698493", +MET,X1008_splice,Oncogenic,Gain-of-function,"15735036, 16397241, 19096300", +MET,V1220I,Likely Oncogenic,Gain-of-function,19783361, +MET,Y1003C,Likely Oncogenic,Likely Gain-of-function,"16227611, 15123609, 11741535", +MET,D1228N,Likely Oncogenic,Likely Gain-of-function,"9826708, 27343442", +U2AF1,S34Y,Oncogenic,Switch-of-function,"22158538, 25267526, 25311244", +U2AF1,Q157R,Oncogenic,Switch-of-function,"25267526, 25311244", +U2AF1,S34F,Likely Oncogenic,Switch-of-function,"25965570, 22158538, 25267526, 25311244", +U2AF1,Q157P,Likely Oncogenic,Switch-of-function,"25267526, 25311244", +KMT2C,A1685S,Likely Oncogenic,Loss-of-function,"25998713, 25151357", +KMT2C,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,"23259788, 19433796, 25537518", +KMT2C,Deletion,Likely Oncogenic,Likely Loss-of-function,"23166019, 11891048, 24081332, 24794707, 9834205", +KMT2C,S3660L,Likely Neutral,Likely Neutral,24965397, +FAT1,P4309A,Likely Oncogenic,Likely Loss-of-function,23354438, +FAT1,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,"24718888, 26905694, 23354438", +FAT1,Deletion,Oncogenic,Loss-of-function,"21617878, 23354438", +FAT1,T4511I,Likely Oncogenic,Likely Loss-of-function,23354438, +FAT1,A4419S,Likely Oncogenic,Likely Loss-of-function,23354438, +ARID1B,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,"23660946, 22233809, 26340334", +ARID1B,Deletion,Likely Oncogenic,Likely Loss-of-function,"23202128, 25674384, 26340334", +PIK3CA,E453A,Likely Oncogenic,Likely Gain-of-function,"20593314, 21266528", +PIK3CA,H1047R,Oncogenic,Gain-of-function,"16322248, 19029981, 22960745, 16341083, 22214849, 16432179, 26627007, 21822287, 27126994, 25079552, 22120714, 21324922, 23940356, 25631445, 20593314, 22941189, 22370636, 23787421, 23636398, 17376864", +PIK3CA,G106R,Likely Oncogenic,Gain-of-function,21266528, +PIK3CA,E116K,Likely Neutral,Likely Neutral,17376864, +PIK3CA,E542G,Inconclusive,Inconclusive,"17990317, 25054828, 22553375, 25401499", +PIK3CA,Amplification,Likely Oncogenic,Likely Gain-of-function,"21720365, 22960745, 17992665, 23136191, 19706770, 28481359, 22292935, 22994622, 19697359, 25631445, 24608574, 26876212, 23636398, 27095573, 17803655", +PIK3CA,R93W,Likely Oncogenic,Gain-of-function,"20593314, 21266528, 22949682", +PIK3CA,R38H,Oncogenic,Gain-of-function,"15930273, 20593314, 17376864", +PIK3CA,N345I,Likely Oncogenic,Likely Gain-of-function,"20593314, 26627007", +PIK3CA,V344A,Likely Oncogenic,Likely Gain-of-function,"20593314, 21266528", +PIK3CA,D350G,Likely Oncogenic,Gain-of-function,24265155, +PIK3CA,I31M,Likely Neutral,Likely Neutral,26627007, +PIK3CA,A1066V,Likely Neutral,Likely Neutral,"27465249, 22430209", +PIK3CA,M1043I,Oncogenic,Gain-of-function,"22120714, 17376864", +PIK3CA,E453Q,Likely Oncogenic,Likely Gain-of-function,"15930273, 20593314", +PIK3CA,C378R,Likely Oncogenic,Likely Gain-of-function,17363507, +PIK3CA,T1025S,Oncogenic,Gain-of-function,17376864, +PIK3CA,H1047L,Oncogenic,Gain-of-function,"20593314, 26627007, 22120714, 17376864", +PIK3CA,E545G,Oncogenic,Gain-of-function,"20593314, 26627007, 17376864", +PIK3CA,H1047Y,Oncogenic,Gain-of-function,"20593314, 26627007, 17376864", +PIK3CA,E545Q,Oncogenic,Gain-of-function,"20593314, 26627007", +PIK3CA,M1043V,Oncogenic,Gain-of-function,17376864, +PIK3CA,A1020V,Likely Neutral,Likely Neutral,26627007, +PIK3CA,E110K,Likely Oncogenic,Likely Gain-of-function,23619167, +PIK3CA,G1049R,Oncogenic,Gain-of-function,26627007, +PIK3CA,H450_P458del,Oncogenic,Gain-of-function,27126994,"Croessmann et al, AACR Annual Meeting 2017, Poster # 1772 http://www.abstractsonline.com/pp8/#!/4292/presentation/1303" +PIK3CA,G106D,Likely Oncogenic,Likely Gain-of-function,"27555788, 15930273, 21266528", +PIK3CA,G106_R108del,Likely Oncogenic,Likely Gain-of-function,19394761, +PIK3CA,G118D,Likely Oncogenic,Gain-of-function,22949682, +PIK3CA,K111N,Likely Oncogenic,Likely Gain-of-function,"18074223, 21266528, 26627007, 22949682, 17376864", +PIK3CA,E545K,Oncogenic,Gain-of-function,"16322248, 20593314, 16432179, 26627007, 17376864", +PIK3CA,E542V,Oncogenic,Gain-of-function,26627007, +PIK3CA,P449_L455del,Likely Oncogenic,Gain-of-function,"20593314, 21266528, 27126994","Croessmann et al. Abstract# 1772, AACR 2017 http://www.abstractsonline.com/pp8/#!/4292/presentation/1303" +PIK3CA,N1068fs*4,Likely Oncogenic,Gain-of-function,21703185, +PIK3CA,E545A,Oncogenic,Gain-of-function,"20593314, 26627007, 17376864", +PIK3CA,Q60K,Likely Neutral,Likely Neutral,18074223, +PIK3CA,R88Q,Likely Oncogenic,Gain-of-function,22949682, +PIK3CA,I391M,Likely Neutral,Likely Neutral,20530683, +PIK3CA,D1029Y,Likely Oncogenic,Likely Gain-of-function,19394761, +PIK3CA,R108H,Likely Oncogenic,Gain-of-function,18829572, +PIK3CA,N345K,Oncogenic,Gain-of-function,"18074223, 20593314, 22949682, 17376864", +PIK3CA,E453K,Oncogenic,Gain-of-function,"20593314, 21266528, 26627007", +PIK3CA,N1044K,Oncogenic,Gain-of-function,26627007, +PIK3CA,E81K,Likely Oncogenic,Likely Gain-of-function,"25915946, 21266528", +PIK3CA,Q546R,Oncogenic,Gain-of-function,"17626883, 26627007", +PIK3CA,Q546E,Oncogenic,Gain-of-function,26627007, +PIK3CA,P539R,Oncogenic,Gain-of-function,17376864, +PIK3CA,E542Q,Likely Oncogenic,Likely Gain-of-function,"16432179, 26627007, 17376864", +PIK3CA,Q546P,Oncogenic,Gain-of-function,"17626883, 17376864", +PIK3CA,R93Q,Likely Oncogenic,Likely Gain-of-function,21266528, +PIK3CA,E542K,Oncogenic,Gain-of-function,"20593314, 16432179, 26627007, 17376864", +PIK3CA,Q546K,Oncogenic,Gain-of-function,"27126994, 17376864", +PIK3CA,K111E,Oncogenic,Gain-of-function,"18074223, 21266528, 22949682", +PIK3CA,Exon 20 mutations,Likely Oncogenic,Likely Gain-of-function,22039088, +PIK3CA,R115L,Likely Neutral,Likely Neutral,23619167, +PIK3CA,P447_L455del,Oncogenic,Gain-of-function,27126994,"Croessmann et al, AACR Annual Meeting 2017, Poster # 1772 http://www.abstractsonline.com/pp8/#!/4292/presentation/1303" +PIK3CA,E365K,Likely Oncogenic,Gain-of-function,21266528, +PIK3CA,E78K,Inconclusive,Inconclusive,27126994, +PIK3CA,G914R,Likely Oncogenic,Likely Gain-of-function,"22228622, 22729224", +PIK3CA,P449T,Oncogenic,Gain-of-function,20530683, +PIK3CA,C420R,Oncogenic,Gain-of-function,"18074223, 21266528, 22949682", +PIK3CA,G106V,Likely Oncogenic,Gain-of-function,"15930273, 21266528", +PIK3CA,E579K,Likely Oncogenic,Likely Gain-of-function,17376864, +PIK3CA,H701P,Likely Neutral,Likely Neutral,"18074223, 17376864", +PIK3CB,N553S,Likely Oncogenic,Likely Gain-of-function,"18755892, 26000489", +PIK3CB,D1067V,Oncogenic,Gain-of-function,25982275, +PIK3CB,E1051K,Likely Oncogenic,Likely Gain-of-function,"18755892, 26000489", +PIK3CB,D1067A,Likely Oncogenic,Gain-of-function,26759240, +PIK3CB,D1067Y,Oncogenic,Gain-of-function,26759240, +PIK3CB,Amplification,Oncogenic,Gain-of-function,"24418330, 26442967, 16432180, 25533673", +PIK3CB,ACPP-PIK3CB Fusion,Likely Oncogenic,Likely Gain-of-function,"26000489, 16432180", +PIK3CB,R48W,Likely Oncogenic,Likely Gain-of-function,"18755892, 26000489", +PIK3CB,E633K,Likely Oncogenic,Likely Gain-of-function,"23734178, 20668451", +PIK3CB,Fusions,Likely Oncogenic,Likely Gain-of-function,"26000489, 16432180", +PIK3CB,E552K,Likely Oncogenic,Gain-of-function,16339315, +PIM1,Y53H,Inconclusive,Inconclusive,23755147, +PIM1,E135K,Inconclusive,Inconclusive,"23755147, 15808862, 19734423", +PIM1,P81S,Likely Oncogenic,Likely Loss-of-function,15808862, +PIM1,P123M,Likely Neutral,Likely Neutral,15808862, +PIM1,H68Y,Likely Oncogenic,Likely Gain-of-function,15808862, +PIM1,E142D,Inconclusive,Inconclusive,23755147, +PIM1,L193F,Likely Oncogenic,Likely Loss-of-function,15808862, +PIM1,N82K,Likely Neutral,Likely Loss-of-function,15808862, +PIM1,E124Q,Inconclusive,Inconclusive,23755147, +PIK3CD,N334K,Likely Oncogenic,Gain-of-function,24165795, +PIK3CD,E525K,Likely Oncogenic,Gain-of-function,"24136356, 24165795", +PIK3CD,E1021K,Likely Oncogenic,Gain-of-function,"24136356, 24165795", +YAP1,Fusions,Likely Oncogenic,Likely Gain-of-function,"23737213, 25965568, 24553141", +YAP1,YAP1-FAM118B Fusion,Likely Oncogenic,Likely Gain-of-function,25965575, +YAP1,YAP1-MAMLD1 Fusion,Likely Oncogenic,Likely Gain-of-function,25965575, +YAP1,YAP1-TFE3 Fusion,Likely Oncogenic,Likely Gain-of-function,23737213, +YAP1,Amplification,Oncogenic,Gain-of-function,"16140918, 15586366, 16814713, 24336504, 19952108, 15824737, 8569172, 10092132, 17114655, 20842732, 23502453, 24511017, 12651874, 12208731, 19551889", +PIK3R1,K459_S460delinsN,Oncogenic,Loss-of-function,20713702, +PIK3R1,W237_Y242del,Likely Oncogenic,Likely Loss-of-function,24367658, +PIK3R1,G376R,Likely Oncogenic,Loss-of-function,20713702, +PIK3R1,X434_splice,Likely Oncogenic,Loss-of-function,"25488983, 25133428", +PIK3R1,R162*,Likely Oncogenic,Likely Loss-of-function,24367658, +PIK3R1,X475_splice,Likely Oncogenic,Loss-of-function,"25488983, 25133428", +PIK3R1,K288Q,Likely Oncogenic,Likely Loss-of-function,24367658, +PIK3R1,X582_splice,Likely Oncogenic,Likely Loss-of-function,"25488983, 25284480, 25133428", +PIK3R1,I559_D560insDKRMNS,Oncogenic,Loss-of-function,20713702, +PIK3R1,N564D,Oncogenic,Loss-of-function,24367658, +PIK3R1,T576del,Oncogenic,Loss-of-function,20713702, +PIK3R1,Deletion,Likely Oncogenic,Likely Loss-of-function,"24229379, 25488983, 25133428", +PIK3R1,R262T,Likely Oncogenic,Likely Loss-of-function,24367658, +PIK3R1,Q579_L581del,Oncogenic,Loss-of-function,19962665, +PIK3R1,N564K,Likely Oncogenic,Loss-of-function,20713702, +PIK3R1,E439del,Likely Oncogenic,Loss-of-function,20713702, +PIK3R1,D560Y,Likely Oncogenic,Loss-of-function,20713702, +PIK3R1,R574fs,Oncogenic,Loss-of-function,20713702, +PIK3R1,E137K,Likely Oncogenic,Likely Loss-of-function,24367658, +PIK3R1,K379E,Oncogenic,Loss-of-function,20713702, +PIK3R1,E160*,Oncogenic,Loss-of-function,"25284480, 21984976", +PIK3R1,R503W,Oncogenic,Loss-of-function,"25957691, 21984976", +PIK3R1,L370fs,Likely Oncogenic,Likely Loss-of-function,25284480, +PIK3R1,E218*,Likely Oncogenic,Likely Loss-of-function,24367658, +PIK3R1,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,"25488983, 25284480, 25133428", +PIK3R1,R348*,Oncogenic,Loss-of-function,"21478295, 25284480, 21984976", +PIK3R2,D557H,Likely Oncogenic,Likely Loss-of-function,"26860062, 26520804", +PIK3R2,N561D,Oncogenic,Gain-of-function,21984976, +PIK3R2,A727V,Likely Neutral,Likely Neutral,21984976, +PIK3R2,A36E,Likely Neutral,Likely Neutral,21984976, +PIK3R2,G373R,Likely Oncogenic,Gain-of-function,"26520804, 22729224", +PIK3R2,K376N,Inconclusive,Inconclusive,21984976, +PIK3R2,A171V,Oncogenic,Gain-of-function,21984976, +PIK3R2,Amplification,Likely Oncogenic,Likely Gain-of-function,25502460, +PIK3R2,S273C,Likely Neutral,Likely Neutral,21984976, +MITF,Amplification,Likely Oncogenic,Likely Gain-of-function,"15716956, 12086670, 15607961, 15623583", +ARID5B,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,"8543152, 15640446, 8622680","Kawamata and Itakura Abstract# LB-150, AACR 2016 http://cancerres.aacrjournals.org/content/76/14_Supplement/LB-150" +HRAS,G12A,Likely Oncogenic,Likely Gain-of-function,"9219684, 21993244, 25013473", +HRAS,P34R,Likely Oncogenic,Likely Gain-of-function,"16474404, 8246952", +HRAS,G13D,Likely Oncogenic,Likely Gain-of-function,"26561417, 9219684, 26037647, 21993244, 22722830, 20147967", +HRAS,G12D,Oncogenic,Gain-of-function,"9219684, 21993244, 24123531", +HRAS,A146T,Oncogenic,Gain-of-function,"17054105, 19075190, 20570890, 20147967, 2403644", +HRAS,Q61L,Oncogenic,Gain-of-function,"22256804, 10574788, 9219684, 21993244, 20194776", +HRAS,A146V,Likely Oncogenic,Likely Gain-of-function,18247425, +HRAS,F28L,Likely Oncogenic,Gain-of-function,25600866, +HRAS,Y64A,Likely Oncogenic,Likely Gain-of-function,24516166, +HRAS,G12S,Oncogenic,Gain-of-function,"9219684, 21993244, 20979192, 25284075, 24129065", +HRAS,G13R,Likely Oncogenic,Likely Gain-of-function,"9219684, 21993244", +HRAS,G12C,Likely Oncogenic,Likely Gain-of-function,"25705018, 9219684, 21993244, 24256730, 16051643, 26841430", +HRAS,G12V,Oncogenic,Gain-of-function,"9219684, 21993244, 24240680, 22589270", +HRAS,K117R,Oncogenic,Gain-of-function,"17054105, 16443854, 20570890, 24247240, 20147967", +HRAS,G13C,Likely Oncogenic,Likely Gain-of-function,"25705018, 9219684, 21993244, 17211612, 21079152", +HRAS,Q61H,Likely Oncogenic,Likely Gain-of-function,"10574788, 25705018, 9219684, 21993244, 20194776, 20147967", +HRAS,Q61R,Likely Oncogenic,Likely Gain-of-function,"10574788, 9219684, 21993244, 20194776, 25437878", +HRAS,T58I,Likely Oncogenic,Likely Gain-of-function,26888048, +HRAS,Amplification,Likely Oncogenic,Likely Gain-of-function,"8221670, 3283542, 1855225", +HRAS,K117N,Likely Oncogenic,Likely Gain-of-function,20570890, +HRAS,G13V,Likely Oncogenic,Likely Gain-of-function,"9219684, 21993244, 22589270, 18713003", +HRAS,A59T,Likely Oncogenic,Likely Gain-of-function,1730690, +HRAS,Q61K,Oncogenic,Gain-of-function,"10574788, 18073111, 9219684, 21993244, 20194776", +HRAS,Q22K,Likely Oncogenic,Likely Gain-of-function,17412879, +HRAS,A59G,Likely Oncogenic,Gain-of-function,"17084704, 20838576", +MLH1,R755S,Likely Oncogenic,Likely Loss-of-function,"23435383, 24362816", +MLH1,N38S,Likely Oncogenic,Likely Loss-of-function,15475387, +MLH1,M587V,Inconclusive,Inconclusive,18206535, +MLH1,Deletion,Likely Oncogenic,Loss-of-function,"12697830, 11793442, 10359802, 17086208, 20864418, 17135187, 20533529, 16623753, 18337503", +MLH1,G67W,Likely Oncogenic,Loss-of-function,"16528606, 24362816, 17510385, 9927034", +MLH1,P603R,Likely Neutral,Likely Neutral,"17510385, 21404117", +MLH1,A120S,Likely Oncogenic,Loss-of-function,24755471, +MLH1,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,"12697830, 10359802, 17086208, 24362816, 16216036, 16623753, 15713769, 7892206, 11781295", +MLH1,E172K,Inconclusive,Inconclusive,"24755471, 20668451", +MLH1,V384D,Likely Neutral,Likely Neutral,"12037578, 24362816", +MLH1,T82A,Likely Oncogenic,Loss-of-function,"24362816, 22736432", +MLH1,R265C,Oncogenic,Loss-of-function,"19419416, 18205192, 11781295", +MLH1,K618T,Likely Neutral,Likely Neutral,"24362816, 19863800", +MLH1,Q689R,Likely Neutral,Likely Neutral,"24362816, 25092538", +MLH1,R659P,Oncogenic,Loss-of-function,"16724012, 11793442, 23435383", +MLH1,D737V,Inconclusive,Inconclusive,"23435383, 24362816", +MLH1,A111P,Likely Oncogenic,Likely Loss-of-function,20020535, +MLH1,R659L,Likely Oncogenic,Likely Loss-of-function,23435383, +MLH1,G67R,Likely Oncogenic,Likely Loss-of-function,"18383312, 21120944", +MLH1,L622H,Inconclusive,Inconclusive,"23435383, 24362816", +MLH1,L559R,Likely Oncogenic,Loss-of-function,"16724012, 23435383, 24362816", +MLH1,R725C,Inconclusive,Inconclusive,"24362816, 23403630", +MLH1,R389Q,Likely Neutral,Neutral,17510385, +MLH1,L749P,Inconclusive,Inconclusive,"23435383, 24362816, 20533529", +MLH1,R265S,Likely Oncogenic,Likely Loss-of-function,"20020535, 17210669, 24362816", +MLH1,E433Q,Likely Neutral,Neutral,21136174, +MLH1,R217C,Likely Neutral,Likely Neutral,"12810663, 17510385, 11781295", +MLH1,L582F,Inconclusive,Inconclusive,"23435383, 24362816", +MLH1,G101S,Likely Oncogenic,Likely Loss-of-function,"22290698, 24362816, 24278394", +MLH1,I219V,Likely Neutral,Likely Neutral,"24362816, 11781295", +MLH1,N551T,Likely Oncogenic,Likely Loss-of-function,"23435383, 24362816", +MLH1,P648S,Likely Oncogenic,Loss-of-function,"16724012, 23435383, 24362816", +MLH1,K618A,Likely Oncogenic,Likely Loss-of-function,"16724012, 22426235, 24362816, 20533529, 18205192", +MLH1,V716M,Likely Neutral,Likely Neutral,"24362816, 21120944", +MLH1,P654L,Inconclusive,Inconclusive,23435383, +MLH1,P648L,Likely Oncogenic,Loss-of-function,"23435383, 24362816", +MLH1,A441T,Inconclusive,Inconclusive,19117025, +MLH1,T117M,Likely Oncogenic,Loss-of-function,"24362816, 20176959, 8566964, 12919140, 11781295", +MLH1,L550P,Likely Oncogenic,Likely Loss-of-function,"23435383, 24362816", +MLH1,V506A,Oncogenic,Loss-of-function,"23435383, 24362816, 18383312", +FGF3,Amplification,Inconclusive,Inconclusive,"24265351, 22890726, 10845805, 9205106", +FGF4,Amplification,Inconclusive,Inconclusive,"24265351, 22890726", +KMT2A,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,25998713, +KMT2A,Amplification,Inconclusive,Inconclusive,"17908926, 15378024", +KMT2A,Fusions,Likely Oncogenic,Likely Gain-of-function,"25998713, 23628958, 8681380, 11265751, 18455126", +AKT1,V271A,Oncogenic,Gain-of-function,23134728, +AKT1,E267G,Likely Oncogenic,Likely Gain-of-function,27147599, +AKT1,Amplification,Likely Oncogenic,Gain-of-function,"14655756, 12631397, 1409633, 24896186, 17616691, 3037531, 11485901", +AKT1,R370C,Likely Oncogenic,Likely Gain-of-function,27147599, +AKT1,D323H,Likely Oncogenic,Gain-of-function,"23134728, 20886116", +AKT1,Q79E,Oncogenic,Gain-of-function,23134728, +AKT1,T195I,Oncogenic,Gain-of-function,23134728, +AKT1,R200A,Likely Neutral,Neutral,23134728, +AKT1,E17K,Oncogenic,Gain-of-function,"23134728, 20440266, 23741320, 18256540, 21793738, 17611497, 9843996", +AKT1,L362R,Likely Neutral,Neutral,23134728, +AKT1,Q79K,Likely Oncogenic,Gain-of-function,"23134728, 20886116, 24265152", +AKT1,L321A,Oncogenic,Gain-of-function,23134728, +AKT1,C77F,Likely Oncogenic,Likely Gain-of-function,"22722193, 23237847", +AKT1,L52R,Oncogenic,Gain-of-function,"23134728, 27147599, 20886116", +AKT1,K189N,Oncogenic,Gain-of-function,23134728, +AKT1,L202F,Likely Neutral,Neutral,23134728, +AKT1,Q59E,Likely Neutral,Neutral,23134728, +AKT1,R23A,Oncogenic,Gain-of-function,23134728, +AKT1,N53A,Oncogenic,Gain-of-function,23134728, +AKT1,P42T,Likely Neutral,Likely Neutral,"23134728, 23237847, 19706770", +AKT1,D32Y,Likely Neutral,Likely Neutral,"23134728, 23237847, 19706770", +AKT1,K39N,Likely Neutral,Likely Neutral,"23134728, 23237847, 19706770", +AKT1,G311D,Likely Oncogenic,Likely Switch-of-function,"25551293, 22460905", +AKT1,V270A,Oncogenic,Gain-of-function,23134728, +AKT1,K179M,Likely Oncogenic,Likely Switch-of-function,"7774014, 25551293", +AKT1,E49K,Oncogenic,Gain-of-function,19802009, +AKT1,E40K,Oncogenic,Gain-of-function,"9690513, 9843996", +AKT1,L78T,Oncogenic,Gain-of-function,23134728, +AKT1,R328A,Oncogenic,Gain-of-function,23134728, +AKT1,D325A,Oncogenic,Gain-of-function,23134728, +AKT1,W80A,Likely Oncogenic,Gain-of-function,"25856301, 18669636, 25551293", +AKT1,E191A,Oncogenic,Gain-of-function,23134728, +AKT2,H355M,Oncogenic,Gain-of-function,25551293, +AKT2,D399N,Likely Oncogenic,Gain-of-function,19738612, +AKT2,BCAM-AKT2 Fusion,Likely Oncogenic,Gain-of-function,25733895, +AKT2,D32H,Likely Oncogenic,Gain-of-function,19738612, +AKT2,R170W,Oncogenic,Gain-of-function,25551293, +AKT2,Amplification,Oncogenic,Gain-of-function,8622988, +AKT2,E17K,Oncogenic,Gain-of-function,"19372382, 24285683, 21979934, 17611497", +AKT2,G161V,Likely Oncogenic,Switch-of-function,25551293, +AKT2,R368C,Likely Oncogenic,Gain-of-function,"19738612, 25551293", +AKT2,I289M,Oncogenic,Gain-of-function,25551293, +AKT2,K181M,Likely Oncogenic,Switch-of-function,25551293, +AKT2,Fusions,Likely Oncogenic,Likely Gain-of-function,25733895, +FGFR1,Amplification,Oncogenic,Gain-of-function,"24265351, 23658459, 22960745, 26451490, 15863030, 15863033, 21160078, 24476821, 25677745, 17121884", +FGFR1,E664K,Likely Neutral,Likely Loss-of-function,19733072, +FGFR1,BCR-FGFR1 Fusion,Likely Oncogenic,Gain-of-function,"11739186, 20226962", +FGFR1,Fusions,Likely Oncogenic,Likely Gain-of-function,23558953, +FGFR1,ERLIN2?FGFR1 Fusion,Likely Oncogenic,Gain-of-function,23558953, +FGFR1,V561M,Likely Oncogenic,Likely Gain-of-function,"15157880, 25686244", +FGFR1,FGFR1-TACC1 Fusion,Oncogenic,Gain-of-function,"22837387, 23558953", +FGFR1,FGFR1OP1-FGFR1 Fusion,Likely Oncogenic,Gain-of-function,"11689702, 16690081, 21330321, 20226962", +FGFR1,A263V,Likely Neutral,Likely Neutral,26826182, +FGFR1,CUX1-FGFR1 Fusion,Likely Oncogenic,Gain-of-function,21330321, +FGFR1,ZNF198-FGFR1 Fusion,Likely Oncogenic,Gain-of-function,"20226962, 10887137, 10935490", +FGFR1,N546K,Oncogenic,Gain-of-function,"24777483, 24806303, 19224897, 24705251, 22820256, 16186508, 23817572, 24140581, 14602678", +FGFR1,K656E,Likely Oncogenic,Gain-of-function,"15509736, 23817572", +FGFR1,CEP110-FGFR1 Fusion,Likely Oncogenic,Gain-of-function,"10688839, 20226962", +FGFR3,D617G,Likely Neutral,Likely Loss-of-function,26992226, +FGFR3,R669G,Likely Oncogenic,Gain-of-function,26992226, +FGFR3,D646Y,Likely Neutral,Likely Neutral,26992226, +FGFR3,G637W,Likely Neutral,Likely Loss-of-function,26992226, +FGFR3,K650R,Likely Oncogenic,Likely Gain-of-function,"11055896, 19749790", +FGFR3,C582F,Likely Neutral,Likely Neutral,26992226, +FGFR3,K508M,Inconclusive,Inconclusive,22837387, +FGFR3,A500T,Likely Neutral,Likely Neutral,26992226, +FGFR3,Amplification,Oncogenic,Gain-of-function,"17344846, 20094046, 19821490", +FGFR3,K650Q,Likely Oncogenic,Likely Gain-of-function,"11055896, 19749790", +FGFR3,D641G,Likely Oncogenic,Gain-of-function,26992226, +FGFR3,G375C,Likely Oncogenic,Gain-of-function,22529939, +FGFR3,V555M,Likely Oncogenic,Gain-of-function,26992226, +FGFR3,IGH-FGFR3 Fusion,Oncogenic,Gain-of-function,17107900, +FGFR3,E627D,Likely Neutral,Likely Neutral,26992226, +FGFR3,K650N,Likely Oncogenic,Likely Gain-of-function,"11055896, 19749790", +FGFR3,K650T,Likely Oncogenic,Likely Gain-of-function,"11055896, 19749790", +FGFR3,G380R,Likely Oncogenic,Gain-of-function,"12461689, 10646125, 10611230, 21324899", +FGFR3,H643D,Likely Neutral,Likely Neutral,26992226, +FGFR3,S371C,Likely Oncogenic,Gain-of-function,12009017, +FGFR3,E466K,Likely Neutral,Likely Neutral,26992226, +FGFR3,F384L,Likely Neutral,Likely Neutral,11157491, +FGFR3,N540S,Likely Oncogenic,Gain-of-function,26992226, +FGFR3,N653H,Likely Neutral,Likely Neutral,26992226, +FGFR3,Y647C,Likely Oncogenic,Likely Gain-of-function,26992226, +FGFR3,P572A,Likely Neutral,Likely Neutral,26992226, +FGFR3,K650E,Likely Oncogenic,Gain-of-function,"19749790, 11429702", +FGFR3,I538V,Likely Oncogenic,Gain-of-function,26992226, +FGFR3,Y373C,Oncogenic,Gain-of-function,"19749790, 16338952, 11429702", +FGFR3,D641N,Likely Oncogenic,Gain-of-function,26992226, +FGFR3,N540K,Oncogenic,Gain-of-function,26992226, +FGFR3,FGFR3 - BAIAP2L1 Fusion,Oncogenic,Gain-of-function,23175443, +FGFR3,Fusions,Likely Oncogenic,Likely Gain-of-function,"23298836, 23661334, 23558953", +FGFR3,K650M,Likely Oncogenic,Likely Gain-of-function,"11055896, 19749790, 10053006", +FGFR3,I538F,Likely Neutral,Likely Neutral,26992226, +FGFR3,A391E,Likely Oncogenic,Gain-of-function,23437153, +FGFR3,G697C,Likely Neutral,Likely Neutral,26992226, +FGFR3,V677I,Likely Neutral,Likely Neutral,26992226, +FGFR3,FGFR3-TACC3 Fusion,Oncogenic,Gain-of-function,"25609060, 22837387", +FGFR3,S249C,Oncogenic,Gain-of-function,"19749790, 16338952, 17384684", +FGFR3,G382D,Likely Oncogenic,Likely Gain-of-function,11429702, +FGFR3,R248C,Oncogenic,Gain-of-function,"22203368, 8640234", +FGFR3,G370C,Likely Oncogenic,Gain-of-function,12009017, +SPOP,W131A,Likely Oncogenic,Likely Loss-of-function,"19818708, 18218622", +SPOP,Y87C,Likely Oncogenic,Loss-of-function,"19818708, 18218622, 25274033, 24508459, 23559371", +SPOP,K129E,Likely Oncogenic,Likely Loss-of-function,"19818708, 18218622, 24990631", +SPOP,Y87N,Likely Oncogenic,Loss-of-function,"19818708, 18218622, 25274033, 24508459, 23559371", +SPOP,S80R,Likely Oncogenic,Loss-of-function,"19818708, 18218622, 25766326", +SPOP,S119N,Likely Oncogenic,Loss-of-function,"19818708, 18218622, 25274033, 24508459, 23559371", +SPOP,P94A,Likely Oncogenic,Loss-of-function,"19818708, 18218622, 25766326", +SPOP,M117V,Likely Oncogenic,Loss-of-function,"19818708, 18218622, 25766326", +SPOP,R121Q,Likely Oncogenic,Loss-of-function,"19818708, 18218622, 25766326", +SPOP,F125V,Likely Oncogenic,Loss-of-function,"19818708, 18218622, 25274033, 24508459, 23559371", +SPOP,K134N,Likely Oncogenic,Likely Loss-of-function,"19818708, 18218622, 24990631", +SPOP,D130A,Likely Oncogenic,Likely Loss-of-function,"19818708, 18218622, 22085717", +SPOP,F133L,Likely Oncogenic,Loss-of-function,"19818708, 18218622, 25274033, 24508459, 23559371", +SPOP,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,26344095, +SPOP,W131G,Likely Oncogenic,Loss-of-function,"19818708, 18218622, 25274033, 24508459, 23559371", +SPOP,E47K,Likely Oncogenic,Loss-of-function,"19818708, 18218622, 25766326", +SPOP,F102C,Likely Oncogenic,Loss-of-function,"19818708, 18218622, 25274033, 24508459, 23559371", +SPOP,G75R,Likely Oncogenic,Loss-of-function,"19818708, 18218622, 25766326", +SPOP,F133V,Likely Oncogenic,Loss-of-function,"19818708, 18218622, 25274033, 24508459, 23559371", +SPOP,N296I,Likely Oncogenic,Likely Loss-of-function,"19818708, 23559371, 24796539", +SPOP,D140G,Likely Oncogenic,Loss-of-function,"19818708, 18218622, 25766326", +SPOP,M117I,Likely Oncogenic,Loss-of-function,"19818708, 18218622, 25766326", +SPOP,E50K,Likely Oncogenic,Loss-of-function,"19818708, 18218622, 25766326", +FGFR2,W290_I291delinsC,Oncogenic,Gain-of-function,26048680, +FGFR2,N549T,Likely Oncogenic,Gain-of-function,17803937, +FGFR2,I642V,Likely Oncogenic,Likely Loss-of-function,19147536, +FGFR2,M535I,Oncogenic,Gain-of-function,23908597, +FGFR2,K526E,Likely Oncogenic,Likely Gain-of-function,"17803937, 16061565", +FGFR2,R251Q,Likely Oncogenic,Likely Loss-of-function,19147536, +FGFR2,Amplification,Oncogenic,Gain-of-function,"20094046, 20101236", +FGFR2,C278F,Likely Oncogenic,Likely Loss-of-function,"20004243, 16844695", +FGFR2,G271E,Likely Oncogenic,Likely Loss-of-function,19147536, +FGFR2,L770V,Inconclusive,Inconclusive,19147536, +FGFR2,K517R,Likely Neutral,Likely Loss-of-function,19147536, +FGFR2,Y375C,Likely Oncogenic,Gain-of-function,"22585574, 22558232", +FGFR2,A648T,Likely Oncogenic,Likely Loss-of-function,19147536, +FGFR2,G701S,Inconclusive,Inconclusive,19147536, +FGFR2,S267_D273dup,Oncogenic,Gain-of-function,26048680, +FGFR2,FGFR2-FAM76A Fusion,Oncogenic,Gain-of-function,24563622, +FGFR2,FGFR2-BICC1 Fusion,Oncogenic,Gain-of-function,"24122810, 23558953", +FGFR2,W290R,Likely Oncogenic,Likely Gain-of-function,"20503384, 22872266", +FGFR2,K310R,Likely Neutral,Likely Neutral,18552176, +FGFR2,A389T,Likely Neutral,Likely Neutral,18552176, +FGFR2,S252W,Oncogenic,Gain-of-function,"17525745, 18552176", +FGFR2,N549S,Oncogenic,Gain-of-function,23908597, +FGFR2,K659N,Likely Oncogenic,Gain-of-function,"17803937, 23527311, 17525745", +FGFR2,N549H,Oncogenic,Gain-of-function,23908597, +FGFR2,K641N,Likely Oncogenic,Likely Gain-of-function,23908597, +FGFR2,K525E,Likely Oncogenic,Gain-of-function,17803937, +FGFR2,R203C,Likely Oncogenic,Gain-of-function,"23527311, 15908952", +FGFR2,FGFR2-TACC3 Fusion,Oncogenic,Gain-of-function,26048680, +FGFR2,T341P,Likely Oncogenic,Gain-of-function,9539778, +FGFR2,L617M,Oncogenic,Gain-of-function,23908597, +FGFR2,Y381D,Likely Oncogenic,Likely Switch-of-function,24908667, +FGFR2,T730S,Likely Neutral,Likely Neutral,26048680, +FGFR2,L617F,Likely Oncogenic,Gain-of-function,23913723, +FGFR2,K641R,Likely Oncogenic,Gain-of-function,"17803937, 23527311", +FGFR2,V564I,Oncogenic,Gain-of-function,23908597, +FGFR2,N549K,Oncogenic,Gain-of-function,"23908597, 17525745, 18552176", +FGFR2,D530N,Likely Oncogenic,Likely Loss-of-function,19147536, +FGFR2,FGFR2-KIAA1967 Fusion,Likely Oncogenic,Likely Gain-of-function,23558953, +FGFR2,M391R,Likely Oncogenic,Gain-of-function,24908667, +FGFR2,K659E,Likely Oncogenic,Likely Gain-of-function,17525745, +FGFR2,FGFR2-MGEA5 Fusion,Likely Oncogenic,Likely Gain-of-function,24550739, +FGFR2,R678G,Likely Oncogenic,Likely Gain-of-function,17803937, +FGFR2,G227E,Likely Neutral,Likely Loss-of-function,19147536, +FGFR2,M537I,Oncogenic,Gain-of-function,23908597, +FGFR2,FGFR2-CCDC6 Fusion,Likely Oncogenic,Gain-of-function,23558953, +FGFR2,E475K,Likely Neutral,Likely Neutral,19147536, +FGFR2,FGFR2-AHCYL1 Fusion,Oncogenic,Gain-of-function,24122810, +FGFR2,Fusions,Likely Oncogenic,Likely Gain-of-function,"25608663, 26258846, 23558953", +FGFR2,E565G,Likely Oncogenic,Gain-of-function,23908597, +FGFR2,E636K,Inconclusive,Inconclusive,19147536, +FGFR2,C382R,Oncogenic,Gain-of-function,"9136983, 17525745", +FGFR2,V248D,Inconclusive,Inconclusive,19147536, +FGFR2,E731K,Likely Oncogenic,Gain-of-function,21928350, +FGFR2,D101Y,Likely Oncogenic,Likely Gain-of-function,18552176, +FGFR2,FGFR2?PPHLN1 Fusion,Oncogenic,Gain-of-function,25608663, +FGFR2,E219K,Likely Oncogenic,Likely Loss-of-function,19147536, +FGFR2,P253R,Oncogenic,Gain-of-function,"24265351, 11121055", +FGFR2,I547V,Oncogenic,Gain-of-function,23908597, +FGFR2,FGFR2-CIT Fusion,Likely Oncogenic,Likely Gain-of-function,23558953, +FGFR2,H213Y,Inconclusive,Inconclusive,19147536, +FGFR2,V755I,Likely Neutral,Likely Neutral,26048680, +FGFR4,N535K,Oncogenic,Gain-of-function,19809159, +FGFR4,V550E,Oncogenic,Gain-of-function,"19809159, 25219510", +FGFR4,Amplification,Oncogenic,Gain-of-function,"15863030, 25053532, 20094046, 23344261", +FGFR4,Y367C,Oncogenic,Gain-of-function,19946327, +PLCG2,R665W,Oncogenic,Gain-of-function,"25972157, 24869598", +PLCG2,L845F,Oncogenic,Gain-of-function,"25972157, 24869598", +KDM6A,Deletion,Likely Oncogenic,Likely Loss-of-function,"19330029, 25225064, 27028180, 22197486","Walker et al. Abstract #1798, ASH, 2009 http://www.bloodjournal.org/content/114/22/1798?sso-checked=true" +KDM6A,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,"19330029, 24633898, 25225064", +ALK,F1174S,Oncogenic,Gain-of-function,"21383740, 23104988", +ALK,L1198P,Oncogenic,Gain-of-function,"21948233, 21383740", +ALK,S1206Y,Oncogenic,Gain-of-function,"22277784, 21383740, 26144315, 24675041", +ALK,S1206C,Oncogenic,Gain-of-function,"21383740, 25421750", +ALK,M1328I,Oncogenic,Gain-of-function,"21383740, 24491302", +ALK,I1171S,Oncogenic,Gain-of-function,"27009859, 21383740, 26464158", +ALK,G881D,Likely Oncogenic,Gain-of-function,21847362, +ALK,S1206R,Oncogenic,Gain-of-function,"21383740, 22034911", +ALK,V597A,Likely Oncogenic,Gain-of-function,"21847362, 12855999", +ALK,F1245V,Oncogenic,Gain-of-function,"21383740, 25517749", +ALK,G1123S,Oncogenic,Gain-of-function,"21948233, 21383740", +ALK,F1174C,Oncogenic,Gain-of-function,"21383740, 26698910, 22034911, 24675041", +ALK,R1060H,Likely Neutral,Neutral,"21383740, 23104988", +ALK,M1166R,Oncogenic,Gain-of-function,"21383740, 25517749, 23104988", +ALK,N1178H,Oncogenic,Gain-of-function,"21383740, 25749034", +ALK,L1198F,Oncogenic,Gain-of-function,"21383740, 21596819, 26698910, 25421750", +ALK,R1464*,Likely Neutral,Neutral,"21383740, 23104988", +ALK,Amplification,Likely Oncogenic,Likely Gain-of-function,"21474455, 24356251, 22614325", +ALK,T1151M,Likely Neutral,Likely Neutral,"27009859, 21383740, 18923525, 25517749, 23104988", +ALK,R1275Q,Oncogenic,Gain-of-function,"18923523, 21383740, 18923525, 25517749, 26829053, 27049722, 26554404, 22072639", +ALK,D1091N,Likely Oncogenic,Likely Gain-of-function,"21383740, 18923525, 23104988, 26786851, 18724359", +ALK,E1210K,Oncogenic,Gain-of-function,"21383740, 22034911", +ALK,A1200V,Likely Neutral,Neutral,"21383740, 23104988", +ALK,Y1278S,Oncogenic,Gain-of-function,"25071110, 21383740, 25517749, 27049722, 23598171", +ALK,D1203N,Likely Oncogenic,Likely Gain-of-function,"21948233, 25421750, 25749034", +ALK,T1087I,Likely Neutral,Neutral,"21383740, 23104988", +ALK,L1122V,Oncogenic,Gain-of-function,"21383740, 25421750", +ALK,C1156Y,Oncogenic,Gain-of-function,"22235099, 21383740, 26144315, 20979473, 26698910, 25749034, 21613408, 24675041", +ALK,R1192P,Oncogenic,Gain-of-function,"27009859, 21383740, 25517749, 27049722", +ALK,G1123D,Oncogenic,Gain-of-function,"21948233, 21383740", +ALK,K1062M,Oncogenic,Gain-of-function,"21383740, 21596819, 18923524", +ALK,I1171N,Oncogenic,Gain-of-function,"21383740, 25517749, 27049722, 24491302, 25749034", +ALK,KIF5B-ALK Fusion,Likely Oncogenic,Gain-of-function,"26144315, 21613408", +ALK,G1128S,Oncogenic,Gain-of-function,25749034, +ALK,T1151dup,Oncogenic,Gain-of-function,"22277784, 21383740, 26144315, 24675041", +ALK,Q1064R,Oncogenic,Gain-of-function,"21383740, 25421750", +ALK,T1151R,Likely Oncogenic,Likely Gain-of-function,"25071110, 21383740", +ALK,CAD-ALK Fusion,Likely Oncogenic,Likely Gain-of-function,26633560, +ALK,C1156F,Oncogenic,Gain-of-function,"21383740, 25749034", +ALK,F1245C,Oncogenic,Gain-of-function,"21383740, 25517749, 27049722, 26554404, 22034911, 23598171", +ALK,D1270G,Likely Neutral,Neutral,"21383740, 25517749", +ALK,H694R,Likely Oncogenic,Gain-of-function,21847362, +ALK,F1174V,Oncogenic,Gain-of-function,"18923523, 21383740, 27049722, 25421750", +ALK,RANBP1-ALK Fusion,Oncogenic,Gain-of-function,21030459, +ALK,L1152R,Oncogenic,Gain-of-function,"21791641, 21383740, 26144315", +ALK,I1170S,Oncogenic,Gain-of-function,"21383740, 25517749", +ALK,I1183T,Likely Neutral,Neutral,"21383740, 25517749", +ALK,Fusions,Likely Oncogenic,Likely Gain-of-function,24060861, +ALK,E1384K,Likely Oncogenic,Gain-of-function,21847362, +ALK,G1201E,Oncogenic,Gain-of-function,"21383740, 21596819", +ALK,L1204F,Likely Neutral,Neutral,"21383740, 23104988", +ALK,RANBP2-ALK Fusion,Oncogenic,Gain-of-function,"21030459, 20979472", +ALK,I1170N,Oncogenic,Gain-of-function,"21383740, 25517749", +ALK,L1152P,Oncogenic,Gain-of-function,"21383740, 24675041", +ALK,G1286R,Likely Neutral,Neutral,"21383740, 25517749", +ALK,S1206F,Inconclusive,Inconclusive,27565908, +ALK,NPM-ALK Fusion,Oncogenic,Gain-of-function,"26133723, 18923525, 26144315, 12424201, 25421750, 12879008, 21613408", +ALK,G1269A,Oncogenic,Gain-of-function,"22235099, 27009859, 26849637, 23401436, 21948233, 22277784, 21383740, 27049722, 26144315, 26698910, 24675041", +ALK,R1275L,Likely Oncogenic,Likely Gain-of-function,23598171, +ALK,G1128A,Oncogenic,Gain-of-function,"21383740, 25517749, 27049722", +ALK,T1343I,Likely Neutral,Likely Neutral,"21383740, 25517749", +ALK,D1349H,Likely Neutral,Likely Neutral,"21383740, 25517749", +ALK,L1196M,Oncogenic,Gain-of-function,"22235099, 23434628, 22277784, 21383740, 25517749, 26144315, 20979473, 26698910, 22034911, 25421750, 21613408, 24675041", +ALK,V1180L,Oncogenic,Gain-of-function,"25228534, 21383740", +ALK,I1171T,Oncogenic,Gain-of-function,"25228534, 21383740, 22034911, 25749034, 24675041, 25736571", +ALK,F1174I,Oncogenic,Gain-of-function,"21383740, 23104988, 25749034", +ALK,R1231Q,Likely Neutral,Neutral,"21383740, 23104988", +ALK,A1099T,Likely Neutral,Neutral,"21383740, 23104988", +ALK,F1174L,Oncogenic,Gain-of-function,"21383740, 25517749, 22072639, 18724359, 21030459, 18923523, 27009859, 21948233, 21596819, 20719933, 18923525, 27049722, 26144315, 26554404, 23104988, 18923524, 26786851, 21242967, 21613408", +ALK,G1202R,Oncogenic,Gain-of-function,"22277784, 21383740, 26144315, 26698910, 24736079, 24675041", +ALK,EML4-ALK Fusion,Oncogenic,Gain-of-function,"21030459, 22235099, 25228534, 21791641, 21948233, 22277784, 18923524, 21613408, 24675041", +ALK,L1196Q,Oncogenic,Gain-of-function,23239810, +ALK,A1234T,Likely Neutral,Likely Neutral,"21383740, 23104988", +ALK,L1240V,Oncogenic,Gain-of-function,"21383740, 23104988", +ALK,P1139S,Oncogenic,Gain-of-function,"21383740, 25421750", +ALK,I1250T,Likely Neutral,Likely Neutral,"21383740, 25517749", +ALK,G1269S,Oncogenic,Gain-of-function,"22277784, 21383740, 22034911, 24675041", +ALK,STRN-ALK Fusion,Likely Oncogenic,Likely Gain-of-function,24613930, +SDHB,S100F,Likely Oncogenic,Loss-of-function,"17639058, 15987702", +RAD54L,G325R,Likely Oncogenic,Loss-of-function,"15056673, 10362365", +SDHC,R133*,Likely Oncogenic,Loss-of-function,24423348, +VEGFA,Amplification,Likely Oncogenic,Gain-of-function,"24687604, 21743435, 24114200, 21495021", +MPL,W515K,Likely Oncogenic,Likely Gain-of-function,"16868251, 17709604", +MPL,W515L,Oncogenic,Gain-of-function,16834459, +MPL,P106L,Likely Oncogenic,Likely Gain-of-function,"25538044, 23351976", +MPL,S505N,Likely Oncogenic,Likely Gain-of-function,"14764528, 8695859", +PMS1,Q233*,Oncogenic,Loss-of-function,8072530, +CARM1,S217A,Likely Oncogenic,Likely Loss-of-function,19843527, +CARM1,S217C,Likely Oncogenic,Likely Loss-of-function,19843527, +CARM1,S217T,Likely Oncogenic,Likely Loss-of-function,19843527, +CARM1,S217E,Likely Oncogenic,Likely Loss-of-function,19843527, +FOXO1,T24A,Likely Oncogenic,Likely Loss-of-function,"17646672, 16670091", +VHL,N150K,Likely Oncogenic,Likely Loss-of-function,14636579, +VHL,S65W,Likely Oncogenic,Loss-of-function,15611064, +VHL,Y112H,Likely Oncogenic,Likely Loss-of-function,10823831, +VHL,R200W,Oncogenic,Loss-of-function,21685897, +VHL,Y98H,Likely Oncogenic,Likely Loss-of-function,10823831, +VHL,P25L,Likely Neutral,Likely Neutral,16884327, +VHL,H191D,Oncogenic,Loss-of-function,21685897, +VHL,A149P,Likely Oncogenic,Likely Loss-of-function,14636579, +VHL,H115R,Likely Oncogenic,Loss-of-function,24969085, +VHL,P86H,Likely Oncogenic,Loss-of-function,"10823831, 10535940", +VHL,Y98N,Likely Oncogenic,Likely Loss-of-function,"10823831, 10535940", +VHL,H115Q,Likely Oncogenic,Likely Loss-of-function,"24969085, 12202531", +VHL,G114R,Likely Oncogenic,Likely Loss-of-function,"14636579, 27179072", +VHL,I151S,Likely Oncogenic,Likely Loss-of-function,"14636579, 27179072", +VHL,F119S,Likely Oncogenic,Likely Loss-of-function,14636579, +VHL,D121G,Likely Oncogenic,Likely Loss-of-function,"26619011, 11865071", +VHL,C162F,Oncogenic,Loss-of-function,21685897, +VHL,L118R,Likely Oncogenic,Likely Loss-of-function,14636579, +VHL,L158V,Likely Oncogenic,Loss-of-function,19602254, +VHL,N78S,Likely Oncogenic,Loss-of-function,19602254, +VHL,R167Q,Oncogenic,Loss-of-function,"10535940, 24755468, 19030229", +VHL,W117C,Likely Oncogenic,Loss-of-function,14636579, +VHL,S111C,Likely Oncogenic,Loss-of-function,22071692, +VHL,S65L,Likely Oncogenic,Loss-of-function,15611064, +VHL,R64P,Likely Oncogenic,Loss-of-function,"10823831, 15611064", +VHL,N90I,Likely Oncogenic,Loss-of-function,10823831, +VHL,Q164R,Likely Oncogenic,Loss-of-function,26503325, +VHL,S65A,Likely Oncogenic,Likely Loss-of-function,"26619011, 15611064", +VHL,E70K,Likely Oncogenic,Likely Loss-of-function,15611064, +VHL,V84L,Inconclusive,Inconclusive,10823831, +VHL,V155A,Likely Oncogenic,Loss-of-function,26503325, +VHL,L188V,Likely Oncogenic,Likely Loss-of-function,10823831, +VHL,L128F,Likely Neutral,Likely Neutral,11865071, +VHL,S68W,Likely Oncogenic,Loss-of-function,"18544564, 15611064", +VHL,L118P,Likely Oncogenic,Likely Loss-of-function,14636579, +VHL,Q145H,Likely Neutral,Loss-of-function,15611064, +VHL,L188Q,Likely Oncogenic,Loss-of-function,19602254, +VHL,L63P,Likely Oncogenic,Loss-of-function,15611064, +VHL,Q96P,Likely Oncogenic,Loss-of-function,10823831, +VHL,R82P,Likely Oncogenic,Loss-of-function,10823831, +VHL,Deletion,Oncogenic,Likely Loss-of-function,"21386872, 23632291, 25093046, 19764026", +VHL,L158Q,Likely Oncogenic,Loss-of-function,2706960, +VHL,R167W,Oncogenic,Loss-of-function,"25563310, 14973063, 23824745, 12202531", +VHL,Y112D,Likely Oncogenic,Likely Loss-of-function,"23744542, 26619011", +VHL,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,"21386872, 12050673, 12004076, 22825683", +VHL,R69C,Likely Oncogenic,Loss-of-function,15611064, +VHL,S111R,Likely Oncogenic,Loss-of-function,22071692, +VHL,L158P,Likely Oncogenic,Loss-of-function,"10535940, 10973499, 19602254", +DNAJB1,DNAJB1-PRKACA Fusion,Oncogenic,Gain-of-function,"24578576, 26437858, 25122662", +MAP2K4,R228K,Oncogenic,Loss-of-function,"20668451, 15122334", +MAP2K4,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,21896780, +MAP2K4,R134Q,Likely Oncogenic,Likely Gain-of-function,"21896780, 26619011", +MAP2K4,G85R,Oncogenic,Loss-of-function,"20668451, 15122334", +MAP2K4,N234I,Oncogenic,Loss-of-function,"20668451, 15122334", +MAP2K4,R154W,Oncogenic,Loss-of-function,"20668451, 15122334", +MAP2K4,R304*,Likely Oncogenic,Loss-of-function,21896780, +MAP2K4,A279T,Oncogenic,Loss-of-function,"21896780, 20668451, 15122334", +MAP2K4,V321M,Likely Oncogenic,Loss-of-function,21896780, +MAP2K4,P326L,Likely Oncogenic,Loss-of-function,21896780, +MAP2K4,S251N,Oncogenic,Loss-of-function,"20668451, 15122334", +RRAS2,Q72L,Oncogenic,Gain-of-function,8052619, +FLT1,Amplification,Inconclusive,Inconclusive,28481359, +FLT3,M664I,Likely Oncogenic,Likely Gain-of-function,25847190, +FLT3,E598_Y599insGLVQVTGSSDNEYFYVDFREYE,Oncogenic,Gain-of-function,"9737679, 11090077, 23631653, 11756186", +FLT3,D324N,Likely Neutral,Neutral,18068628, +FLT3,D835V,Oncogenic,Gain-of-function,"11290608, 15256420, 26108694", +FLT3,Y599_D600insEYEYEYEY,Oncogenic,Gain-of-function,"9737679, 11090077, 23631653", +FLT3,E612_F613insGYVDFREYEYDLKWEFRPRENLEF,Oncogenic,Gain-of-function,"9737679, 11090077, 23631653, 11756186", +FLT3,K868N,Likely Neutral,Loss-of-function,27272783, +FLT3,Y599_D600insSTDNEYFYVDFREYEY,Oncogenic,Gain-of-function,"9737679, 11090077, 23631653", +FLT3,FLT3 internal tandem duplications,Oncogenic,Gain-of-function,23631653, +FLT3,Y599F,Likely Neutral,Likely Loss-of-function,16684964, +FLT3,D600_L601insFREYEYD,Oncogenic,Gain-of-function,"9737679, 11090077, 23631653", +FLT3,M737I,Likely Neutral,Neutral,18068628, +FLT3,D835H,Oncogenic,Gain-of-function,"11290608, 15256420, 26108694", +FLT3,V592G,Oncogenic,Gain-of-function,18068628, +FLT3,F594_R595insSDNEYFYVDF,Oncogenic,Gain-of-function,"9737679, 11090077, 23631653", +FLT3,D835E,Oncogenic,Gain-of-function,"11290608, 15256420, 26108694", +FLT3,F691L,Oncogenic,Gain-of-function,"19318574, 23430109", +FLT3,Y599_D600insPAPQIMSTSTLISENMNIA,Oncogenic,Gain-of-function,"9737679, 11090077, 23631653", +FLT3,S840_N841insGS,Oncogenic,Gain-of-function,"9737679, 11090077, 23631653, 12384447", +FLT3,E598_Y599insDVDFREYE,Oncogenic,Gain-of-function,"9737679, 11090077, 23631653", +FLT3,I836del,Likely Oncogenic,Gain-of-function,23878140, +FLT3,V579A,Oncogenic,Gain-of-function,16410449, +FLT3,T167A,Likely Neutral,Neutral,18068628, +FLT3,V557I,Likely Neutral,Neutral,18068628, +FLT3,D839G,Oncogenic,Gain-of-function,24608088, +FLT3,N841I,Oncogenic,Gain-of-function,15178581, +FLT3,Amplification,Likely Oncogenic,Gain-of-function,"25848357, 27906677", +FLT3,K602_W603insYEYDLK,Oncogenic,Gain-of-function,"9737679, 11090077, 23631653", +FLT3,D835N,Oncogenic,Gain-of-function,"11290608, 15256420, 26108694", +FLT3,S451E,Oncogenic,Gain-of-function,18068628, +FLT3,N676S,Likely Oncogenic,Likely Gain-of-function,25847190, +FLT3,L611_E612insCSSDNEYFYVDFREYEYDLKWEFPRENL,Oncogenic,Gain-of-function,"9737679, 11090077, 23631653, 11756186", +FLT3,D835del,Oncogenic,Gain-of-function,15256420, +FLT3,D600_L601insDFREYEYD,Oncogenic,Gain-of-function,"9737679, 11090077, 23631653", +FLT3,R834Q,Oncogenic,Gain-of-function,18068628, +FLT3,S451F,Oncogenic,Gain-of-function,18068628, +FLT3,N676D,Likely Oncogenic,Likely Gain-of-function,22875611, +FLT3,Y599_D600insGLYVDFREYEY,Oncogenic,Gain-of-function,"9737679, 11090077, 23631653, 11756186", +FLT3,V592A,Oncogenic,Gain-of-function,16410449, +FLT3,V194M,Likely Neutral,Neutral,18068628, +FLT3,D835Y,Oncogenic,Gain-of-function,"11290608, 23631653, 15256420, 26108694, 24255108", +FLT3,W603_E604insDREYEYDLKW,Oncogenic,Gain-of-function,"9737679, 11090077, 23631653", +FLT3,F594L,Oncogenic,Gain-of-function,16410449, +FLT3,Y572C,Oncogenic,Gain-of-function,18068628, +FLT3,F590G,Oncogenic,Gain-of-function,16410449, +FLT3,I867S,Oncogenic,Gain-of-function,24608088, +FLT3,Y842C,Oncogenic,Gain-of-function,15345593, +FLT3,Y591D,Oncogenic,Gain-of-function,16410449, +FLT3,Y364H,Likely Neutral,Neutral,18068628, +FLT3,D835A,Oncogenic,Gain-of-function,"11290608, 15256420, 26108694", +FLT3,L601_K602insREYEYDL,Oncogenic,Gain-of-function,"9737679, 11090077, 23631653, 11756186", +FLT3,N676K,Oncogenic,Gain-of-function,23878140, +FLT3,G831E,Likely Neutral,Neutral,18068628, +FLT3,A627T,Likely Oncogenic,Likely Gain-of-function,15374944, +PMS2,E41A,Likely Oncogenic,Loss-of-function,"20864418, 24027009", +PMS2,E541K,Likely Neutral,Likely Neutral,"24362816, 24027009", +PMS2,L585I,Likely Neutral,Likely Neutral,"24362816, 24027009", +PMS2,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,"12697830, 10439048, 20487569, 7628019, 23582141, 24362816, 21376568, 9500552, 10874005, 7892206, 16144131, 9488480", +PMS2,E5K,Likely Neutral,Likely Neutral,24362816, +PMS2,I18V,Likely Neutral,Likely Neutral,"24362816, 24027009", +PMS2,S46I,Likely Oncogenic,Loss-of-function,"18602922, 23709753, 17557300, 24027009, 2257789, 27435373, 16144131", +PMS2,S46N,Likely Oncogenic,Loss-of-function,24027009, +PMS2,Deletion,Likely Oncogenic,Likely Loss-of-function,"18602922, 23837913, 10439048, 7628019, 9500552, 10874005, 16472587", +PMS2,R20Q,Oncogenic,Loss-of-function,"24027009, 23981578", +PMS2,T485K,Likely Neutral,Likely Neutral,"15256438, 24362816, 24027009", +PMS2,G207E,Likely Oncogenic,Likely Loss-of-function,"19479271, 24027009", +PMS2,G857A,Likely Neutral,Likely Neutral,"24362816, 24027009", +PMS2,P470S,Likely Neutral,Likely Neutral,24362816, +PMS2,I66T,Likely Neutral,Likely Neutral,27435373, +PMS2,R107W,Likely Oncogenic,Loss-of-function,27435373, +PMS2,I668V,Likely Oncogenic,Likely Loss-of-function,25691505, +PMS2,H479Q,Likely Neutral,Likely Neutral,24027009, +SRSF2,P95H,Oncogenic,Loss-of-function,"27135740, 25965569, 26124281, 26261309", +WHSC1,E1099K,Oncogenic,Gain-of-function,"23823660, 24076604", +PPM1D,422_605trunc,Likely Oncogenic,Gain-of-function,"25742468, 24880341, 23907125", +POLE,S459del,Likely Oncogenic,Likely Loss-of-function,25228659, +POLE,P286R,Likely Oncogenic,Loss-of-function,"25228659, 23636398", +POLE,L424V,Likely Oncogenic,Loss-of-function,"23263490, 25228659", +POLE,V411L,Likely Oncogenic,Loss-of-function,"25228659, 23636398", +POLE,S279Y,Likely Oncogenic,Likely Loss-of-function,"25228659, 24472300", +POLE,P286H,Likely Oncogenic,Loss-of-function,25228659, +POLE,P286S,Likely Oncogenic,Loss-of-function,25228659, +POLE,L424I,Likely Oncogenic,Loss-of-function,25228659, +POLE,S297F,Likely Oncogenic,Likely Loss-of-function,"25228659, 24472300", +POLE,F367S,Likely Oncogenic,Loss-of-function,"21157497, 25228659", +POLE,S459F,Likely Oncogenic,Loss-of-function,25228659, +KNSTRN,P26S,Likely Oncogenic,Likely Loss-of-function,25194279, +KNSTRN,R11K,Likely Oncogenic,Likely Loss-of-function,25194279, +KNSTRN,S24F,Oncogenic,Loss-of-function,25194279, +KNSTRN,P28S,Likely Oncogenic,Likely Loss-of-function,25194279, +KNSTRN,A40E,Likely Oncogenic,Likely Loss-of-function,25194279, +PIK3R3,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,"25424831, 27766312", +APC,N1026S,Likely Oncogenic,Loss-of-function,18166348, +APC,R640G,Oncogenic,Loss-of-function,19111562, +APC,Deletion,Likely Oncogenic,Likely Loss-of-function,"8259511, 15643602, 25317407, 11867715", +APC,I1307K,Likely Oncogenic,Likely Loss-of-function,9724771, +APC,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,"11062151, 15561772, 11257105", +APC,A290T,Likely Oncogenic,Likely Loss-of-function,11606402, +RICTOR,Amplification,Oncogenic,Gain-of-function,"19934294, 20978191, 26370156, 19185849", +MSH2,D603N,Oncogenic,Loss-of-function,"21120944, 18951462", +MSH2,A305T,Inconclusive,Inconclusive,18822302, +MSH2,G751R,Likely Oncogenic,Loss-of-function,"24362816, 10732761, 17720936", +MSH2,A272V,Likely Neutral,Likely Neutral,"17101317, 21120944", +MSH2,A636P,Likely Oncogenic,Likely Loss-of-function,"12595050, 10528862", +MSH2,Deletion,Likely Oncogenic,Likely Loss-of-function,"9823339, 21970482, 22781090, 23264089, 17250661", +MSH2,L390F,Likely Neutral,Likely Neutral,24362816, +MSH2,G322D,Likely Neutral,Likely Neutral,24362816, +MSH2,S723F,Likely Oncogenic,Likely Loss-of-function,"24362816, 22102614, 26951660", +MSH2,G674R,Likely Oncogenic,Likely Loss-of-function,18822302, +MSH2,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,"8592341, 11257106, 23391514, 15528792, 24362816, 10946232, 7726159, 8566964", +MSH2,S860L,Likely Neutral,Likely Neutral,"24362816, 22102614", +MSH2,D603G,Inconclusive,Inconclusive,24362816, +MSH3,K383Rfs*32,Likely Oncogenic,Likely Loss-of-function,"8782829, 18922920, 23724141", +IDH1,G70D,Likely Neutral,Loss-of-function,21996744, +IDH1,R132S,Likely Oncogenic,Switch-of-function,"21760534, 25257301, 23630074, 21912393, 22033490, 19935646", +IDH1,R100A,Likely Oncogenic,Switch-of-function,21996744, +IDH1,Y139D,Likely Oncogenic,Gain-of-function,21996744, +IDH1,G97D,Likely Oncogenic,Switch-of-function,21996744, +IDH1,R132G,Oncogenic,Switch-of-function,"23264629, 23630074, 19935646", +IDH1,R132H,Oncogenic,Switch-of-function,"25730874, 23393090, 22763442, 22343901, 23630074, 22343889, 22899282, 19935646", +IDH1,P33S,Likely Neutral,Likely Neutral,27147599, +IDH1,G123R,Likely Neutral,Loss-of-function,20171178, +IDH1,I99M,Likely Neutral,Likely Neutral,21996744, +IDH1,I130M,Likely Neutral,Likely Neutral,21996744, +IDH1,R132C,Oncogenic,Switch-of-function,"23630074, 23954893, 19935646", +IDH1,R49C,Likely Neutral,Loss-of-function,21996744, +IDH1,R132Q,Likely Oncogenic,Likely Switch-of-function,"25730874, 23630074, 19935646", +IDH1,V294M,Likely Neutral,Likely Neutral,21996744, +IDH1,H133Q,Likely Neutral,Likely Neutral,21996744, +IDH1,A134D,Likely Neutral,Loss-of-function,21996744, +IDH1,E190K,Likely Neutral,Likely Neutral,27147599, +IDH2,R172S,Oncogenic,Switch-of-function,"23264629, 20171147", +IDH2,R172G,Likely Oncogenic,Likely Switch-of-function,"21641335, 20171147", +IDH2,R172K,Oncogenic,Switch-of-function,"20171147, 25043045", +IDH2,R172M,Likely Oncogenic,Likely Switch-of-function,"27147599, 20171147", +IDH2,R140Q,Oncogenic,Switch-of-function,"20692206, 23264629, 20171147, 25043045, 24440599, 20847235", +XPO1,C528S,Inconclusive,Inconclusive,"27680702, 23034282", +XPO1,E571K,Likely Oncogenic,Likely Gain-of-function,"21741593, 21642962, 27312795, 26619011, 27479820", +XRCC2,Deletion,Likely Neutral,Likely Loss-of-function,"22464251, 14678973, 10517641", +XRCC2,R188H,Likely Oncogenic,Likely Loss-of-function,12023985, +XRCC2,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,"22464251, 14678973, 10517641", +CREBBP,W1502A,Likely Oncogenic,Loss-of-function,"11691934, 21390130", +CREBBP,R1446C,Likely Oncogenic,Likely Loss-of-function,21390130, +CREBBP,Y1503S,Likely Oncogenic,Loss-of-function,"11691934, 21390130", +CREBBP,Deletion,Likely Oncogenic,Likely Loss-of-function,21390130, +CREBBP,R1563S,Likely Neutral,Likely Neutral,21390130, +CREBBP,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,21390130, +CREBBP,Q1500P,Likely Neutral,Likely Neutral,21390130, +CREBBP,R1446H,Likely Oncogenic,Likely Loss-of-function,21390130, +DIS3,R780K,Oncogenic,Loss-of-function,"26193331, 24150935", +AR,T878S,Oncogenic,Gain-of-function,"9092797, 2260966, 9815822", +AR,P380R,Inconclusive,Inconclusive,25500996, +AR,H875Y,Oncogenic,Gain-of-function,"9092797, 9815822", +AR,L272F,Likely Neutral,Likely Neutral,25500996, +AR,L702H,Oncogenic,Gain-of-function,"11956172, 10835690", +AR,L57Q,Likely Neutral,Loss-of-function,22403669, +AR,G216R,Inconclusive,Inconclusive,25500996, +AR,N235K,Likely Neutral,Likely Loss-of-function,"25500996, 11422119", +AR,W742L,Oncogenic,Gain-of-function,12517791, +AR,Amplification,Oncogenic,Gain-of-function,"7795646, 7511045, 11306464, 12888829, 14702632, 10496349", +AR,W742C,Oncogenic,Gain-of-function,12517791, +AR,A159T,Likely Neutral,Likely Loss-of-function,25500996, +AR,Q58L,Inconclusive,Inconclusive,"12801573, 23637914, 24737579", +AR,ARv567es,Oncogenic,Gain-of-function,"20823238, 19117982, 24449822, 22014572, 23851510, 21552559, 19244107, 20644256", +AR,T878A,Oncogenic,Gain-of-function,"9092797, 2260966, 10363963, 9815822, 25320358", +AR,F876L,Likely Oncogenic,Likely Gain-of-function,"23779130, 2384268", +AR,F877L,Oncogenic,Gain-of-function,"23779130, 23842682, 23580326", +AR,Q120E,Likely Neutral,Likely Neutral,25500996, +AR,Q58_Q59insL,Likely Neutral,Likely Loss-of-function,25500996, +AR,L57del,Likely Neutral,Likely Neutral,25500996, +AR,G248V,Inconclusive,Inconclusive,25500996, +AR,AR-V7,Oncogenic,Gain-of-function,"20823238, 19117982, 24449822, 22014572, 23851510, 21552559, 19244107, 20644256", +ARAF,S214C,Oncogenic,Gain-of-function,"24569458, 15520807", +ARAF,F351L,Oncogenic,Gain-of-function,24652991, +ARAF,S214T,Likely Oncogenic,Gain-of-function,"24569458, 15520807", +ARAF,S214A,Likely Oncogenic,Likely Gain-of-function,"24569458, 26566875, 15520807", +ARAF,N217I,Oncogenic,Gain-of-function,"25608663, 15520807", +ARAF,S214F,Oncogenic,Gain-of-function,"24569458, 15520807", +ARAF,Q347_A348del,Oncogenic,Gain-of-function,24652991, +ARAF,G322S,Likely Oncogenic,Gain-of-function,"25608663, 24569458", +RHOA,G14V,Likely Neutral,Loss-of-function,"24584070, 19515453", +RHOA,E40Q,Likely Oncogenic,Likely Gain-of-function,"26619011, 9565577", +RHOA,G17V,Oncogenic,Loss-of-function,"24413737, 24584070", +RHOA,Overexpression,Oncogenic,Gain-of-function,"10213513, 15448013, 25104222", +RHOA,E40L,Likely Oncogenic,Likely Gain-of-function,"26619011, 9482732", +RHOA,R5Q,Likely Oncogenic,Likely Loss-of-function,25044415, +RHOA,Y34C,Likely Oncogenic,Likely Gain-of-function,"26619011, 9565577", +RHOA,T19N,Likely Oncogenic,Loss-of-function,"19147561, 24584070", +RHOA,Amplification,Oncogenic,Gain-of-function,"10213513, 15448013, 25104222", +RHOA,Y42C,Oncogenic,Loss-of-function,"9482732, 24816253, 24816255", +RHOA,G17E,Likely Oncogenic,Likely Loss-of-function,24816255, +RHOA,L57V,Oncogenic,Loss-of-function,24816253, +RHOA,G17A,Likely Oncogenic,Loss-of-function,"22491204, 12221096, 16472675", +RHOA,Y34F,Likely Oncogenic,Likely Switch-of-function,"24398689, 26619011", +RHOA,E40T,Likely Oncogenic,Likely Gain-of-function,"26619011, 9482732", +RHOA,E40N,Likely Oncogenic,Likely Switch-of-function,"26619011, 9482732", +RHOA,T37A,Likely Oncogenic,Likely Gain-of-function,"19147561, 15993039", +RHOA,E40W,Likely Oncogenic,Likely Loss-of-function,"26619011, 9482732", +NCOR1,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,"21102521, 7566114", +PPP2R1A,P179L,Likely Oncogenic,Likely Loss-of-function,"17174897, 17086192, 18922469", +PPP2R1A,S256Y,Likely Oncogenic,Likely Loss-of-function,"21435433, 17174897, 17086192, 18922469", +PPP2R1A,R183Q,Likely Oncogenic,Likely Loss-of-function,"17174897, 17086192, 18922469", +PPP2R1A,R258H,Inconclusive,Inconclusive,"17174897, 17086192, 18922469", +PPP2R1A,W257C,Likely Oncogenic,Likely Loss-of-function,"21435433, 17174897, 17086192, 18922469", +PPP2R1A,W257G,Likely Oncogenic,Gain-of-function,"21435433, 17174897, 17086192, 18922469, 27272709", +PPP2R1A,S256W,Likely Oncogenic,Likely Loss-of-function,"21435433, 17174897, 17086192, 18922469", +PPP2R1A,R183W,Likely Oncogenic,Likely Loss-of-function,"17174897, 17086192, 18922469", +PPP2R1A,R183P,Likely Oncogenic,Likely Loss-of-function,"17174897, 17086192, 18922469", +PPP2R1A,P179R,Likely Oncogenic,Likely Loss-of-function,"17174897, 17086192, 18922469", +PPP2R1A,R182W,Likely Oncogenic,Likely Loss-of-function,"21435433, 17174897, 17086192, 18922469, 26168268", +PPP2R1A,R258C,Inconclusive,Inconclusive,"17174897, 17086192, 18922469", +PPP2R1A,R183G,Likely Oncogenic,Likely Loss-of-function,"17174897, 17086192, 18922469", +PPP2R1A,S256F,Likely Oncogenic,Likely Loss-of-function,"21435433, 17174897, 17086192, 18922469", +SETD2,Deletion,Oncogenic,Loss-of-function,27282254,"McKinney et al. Abstract #1052, ASH 2016 https://ash.confex.com/ash/2016/webprogram/Paper96954.html" +SETD2,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,"24509477, 25728682, 23417712", +SETD2,R1625C,Oncogenic,Loss-of-function,27528607, +IGF1R,G119T,Likely Oncogenic,Loss-of-function,23045302, +IGF1R,A1374V,Likely Oncogenic,Likely Gain-of-function,22778948, +IGF1R,G1125A,Likely Neutral,Likely Loss-of-function,20103656, +IGF1R,M1255I,Likely Oncogenic,Likely Gain-of-function,22778948, +PPP6C,R264C,Likely Oncogenic,Loss-of-function,23729733, +PPP6C,H114Y,Oncogenic,Loss-of-function,23729733, +PPP6C,S270L,Likely Oncogenic,Loss-of-function,23729733, +PPP6C,P186S,Likely Oncogenic,Loss-of-function,23729733, +CTCF,R339W,Likely Oncogenic,Switch-of-function,11782357, +CTCF,H284N,Likely Oncogenic,Likely Loss-of-function,"11782357, 24794443, 26619011", +CTCF,Deletion,Likely Oncogenic,Likely Loss-of-function,"26330387, 24130125, 19568526", +CTCF,H284Y,Likely Oncogenic,Likely Loss-of-function,"11782357, 24794443, 26619011", +CTCF,H284P,Likely Oncogenic,Likely Loss-of-function,"11782357, 24794443, 26619011", +CTCF,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,"25079317, 24130125, 23636398", +IKBKE,Amplification,Likely Oncogenic,Likely Gain-of-function,"17574021, 25365225", +MTOR,V2006L,Likely Oncogenic,Likely Gain-of-function,"24631838, 26619011", +MTOR,L2427R,Likely Oncogenic,Gain-of-function,27713405, +MTOR,E1799K,Likely Oncogenic,Gain-of-function,24631838, +MTOR,D2512G,Likely Neutral,Likely Neutral,24631838, +MTOR,P2273S,Oncogenic,Gain-of-function,23322780, +MTOR,D2512H,Likely Oncogenic,Gain-of-function,24631838, +MTOR,F1888L,Likely Oncogenic,Gain-of-function,24631838, +MTOR,S2215F,Likely Oncogenic,Gain-of-function,24631838, +MTOR,F1888V,Likely Neutral,Likely Neutral,24631838, +MTOR,A2034V,Likely Neutral,Likely Neutral,27279227, +MTOR,V2006I,Likely Oncogenic,Gain-of-function,24631838, +MTOR,F2108L,Likely Neutral,Likely Neutral,27279227, +MTOR,A1519T,Oncogenic,Gain-of-function,"24631838, 26255626", +MTOR,L1460P,Oncogenic,Gain-of-function,"20190810, 24631838, 26255626", +MTOR,D2512Y,Likely Neutral,Likely Neutral,24631838, +MTOR,E2288K,Oncogenic,Gain-of-function,23322780, +MTOR,T1977I,Oncogenic,Gain-of-function,26432419, +MTOR,A41T,Likely Neutral,Likely Neutral,24631838, +MTOR,I2500M,Likely Oncogenic,Gain-of-function,24631838, +MTOR,M2327I,Likely Oncogenic,Gain-of-function,27279227, +MTOR,S2215T,Likely Neutral,Likely Neutral,24631838, +MTOR,T1977S,Likely Neutral,Likely Neutral,24631838, +MTOR,L1433S,Likely Oncogenic,Gain-of-function,"24631838, 26255626", +MTOR,K1452N,Oncogenic,Gain-of-function,"24631838, 26255626", +MTOR,A41P,Likely Neutral,Likely Neutral,24631838, +MTOR,I2500F,Likely Oncogenic,Gain-of-function,24631838, +MTOR,W1456R,Likely Oncogenic,Likely Gain-of-function,"23322780, 22460905", +MTOR,T1977K,Oncogenic,Gain-of-function,27482884, +MTOR,A1459P,Likely Oncogenic,Gain-of-function,24631838, +MTOR,A8S,Likely Neutral,Likely Neutral,20190810, +MTOR,Y1463S,Likely Oncogenic,Gain-of-function,"24631838, 26255626", +MTOR,R2505P,Oncogenic,Gain-of-function,"20190810, 24631838, 26255626", +MTOR,E2014K,Likely Oncogenic,Gain-of-function,24625776, +MTOR,R2505Q,Likely Neutral,Likely Neutral,24631838, +MTOR,A41S,Likely Neutral,Likely Neutral,24631838, +MTOR,R2430M,Likely Neutral,Likely Neutral,24631838, +MTOR,C1483R,Likely Oncogenic,Gain-of-function,24631838, +MTOR,C1483F,Oncogenic,Gain-of-function,"24631838, 26255626", +MTOR,L2431P,Likely Oncogenic,Likely Gain-of-function,22397650, +MTOR,C1483W,Likely Oncogenic,Gain-of-function,24631838, +MTOR,S2215Y,Likely Oncogenic,Gain-of-function,"20190810, 24631838, 24336570", +MTOR,P2476L,Likely Neutral,Likely Neutral,20190810, +MTOR,R2152C,Likely Neutral,Likely Neutral,24631838, +MTOR,T1977R,Likely Oncogenic,Gain-of-function,24631838, +MTOR,E2419K,Oncogenic,Gain-of-function,24625776, +MTOR,L2230V,Oncogenic,Gain-of-function,27482884, +MTOR,Q2223K,Likely Oncogenic,Gain-of-function,24622468, +MTOR,R2505*,Likely Neutral,Likely Neutral,24631838, +MTOR,C1483Y,Oncogenic,Gain-of-function,"24631838, 26255626", +MTOR,F1888I,Likely Oncogenic,Gain-of-function,24631838, +TET1,MLL-TET1 Fusion,Oncogenic,Gain-of-function,"19144982, 12646957, 23818607, 24323992", +TET1,Deletion,Likely Oncogenic,Likely Loss-of-function,"21625234, 19420352, 25867473", +TET1,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,"21057493, 22156206, 19372391", +SMARCA4,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,"24658002, 24658001, 24658004, 25060813, 18301784", +SMARCA4,R1189*,Likely Oncogenic,Loss-of-function,20137775, +SMARCA4,T910M,Likely Oncogenic,Loss-of-function,"26842758, 23698369", +SMARCA4,G1232D,Likely Oncogenic,Loss-of-function,23698369, +SMARCA4,R1093*,Oncogenic,Loss-of-function,"24658001, 24658004", +SMARCA4,Deletion,Likely Oncogenic,Likely Loss-of-function,"21520050, 23139211, 18381774, 11481457, 26942101, 11163203", +SMARCA4,R978*,Oncogenic,Loss-of-function,"24658002, 24658004", +SMARCB1,Deletion,Likely Oncogenic,Likely Loss-of-function,"11313485, 10521299, 11095756, 23074045, 9892189, 12450796, 22797305, 11263494", +SMARCB1,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,"23620515, 12138206, 9671307, 23435428, 21076395", +FOXP1,R514C,Likely Oncogenic,Likely Loss-of-function,26647308, +FOXP1,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,25329375, +SMO,E518K,Likely Neutral,Likely Neutral,21123452, +SMO,W535L,Likely Oncogenic,Gain-of-function,"25759020, 23636324, 9422511", +SMO,Q635E,Likely Oncogenic,Likely Gain-of-function,25759020, +SMO,W281C,Likely Oncogenic,Gain-of-function,"25759020, 25759019, 25199678", +SMO,C469Y,Likely Oncogenic,Gain-of-function,"2575902, 25759020, 25759019, 25199678", +SMO,D473G,Likely Oncogenic,Likely Gain-of-function,19726788, +SMO,D384N,Likely Oncogenic,Likely Gain-of-function,"25759020, 25759019", +SMO,L412F,Likely Oncogenic,Gain-of-function,"2575902, 25759020, 25759019, 25199678", +SMO,F460L,Likely Oncogenic,Gain-of-function,"2575902, 25759020, 25759019, 25199678", +SMO,N219D,Likely Oncogenic,Likely Gain-of-function,"25759020, 25759019", +SMO,I408V,Likely Oncogenic,Gain-of-function,"2575902, 25759020, 25759019, 25199678", +SMO,T241M,Likely Oncogenic,Gain-of-function,25759019, +SMO,K575M,Likely Oncogenic,Likely Gain-of-function,"16339184, 12499255", +SMO,L221R,Likely Oncogenic,Likely Gain-of-function,"25759020, 25759019", +SMO,D473Y,Inconclusive,Inconclusive,25306392, +SMO,A459V,Likely Oncogenic,Gain-of-function,25759019, +SMO,V414A,Likely Oncogenic,Likely Gain-of-function,"25801792, 26619011", +SMO,H231R,Likely Oncogenic,Likely Gain-of-function,"25759020, 25759019", +SMO,D473H,Likely Oncogenic,Likely Gain-of-function,19726788, +SMO,E518A,Inconclusive,Inconclusive,21123452, +SMO,S387N,Likely Oncogenic,Gain-of-function,25759019, +SMO,V321M,Likely Oncogenic,Gain-of-function,"2575902, 25759020, 25759019, 25199678", +SMO,Amplification,Inconclusive,Inconclusive,"24202394, 26124204, 20215540","Zehir A et al. Nature Medicine, 2017 http://doi:10.1038/nm.4333" +SMO,Q477E,Likely Oncogenic,Likely Gain-of-function,"25759020, 25759019", +CARD11,C49Y,Likely Oncogenic,Gain-of-function,"25930198, 23149938", +CARD11,D387V,Likely Oncogenic,Likely Gain-of-function,23027925, +CARD11,F123I,Likely Oncogenic,Gain-of-function,"20799731, 23149938", +CARD11,D230N,Likely Oncogenic,Likely Gain-of-function,27224912, +CARD11,S250P,Oncogenic,Gain-of-function,"23027925, 18323416, 26776161", +CARD11,D401N,Likely Oncogenic,Gain-of-function,25921526, +CARD11,Amplification,Likely Oncogenic,Likely Gain-of-function,18323416,"Abubaker et al. Abstract# 4192, AACR 2011 http://cancerres.aacrjournals.org/content/71/8_Supplement/4192" +CARD11,G116S,Likely Oncogenic,Gain-of-function,23179749, +CARD11,Y361C,Likely Oncogenic,Likely Gain-of-function,27224912, +CARD11,E626K,Likely Oncogenic,Gain-of-function,26551667, +CARD11,G123S,Likely Oncogenic,Likely Gain-of-function,"23027925, 27224912", +CARD11,L225LI,Likely Oncogenic,Gain-of-function,"20799731, 23149938", +CARD11,E127G,Likely Oncogenic,Gain-of-function,23179749, +CARD11,E93D,Oncogenic,Gain-of-function,23149938, +CARD11,L232LI,Likely Oncogenic,Likely Gain-of-function,23027925, +CARD11,L251P,Oncogenic,Gain-of-function,"23027925, 18323416, 26776161", +MEF2B,K4E,Oncogenic,Loss-of-function,"23974956, 26245647", +MEF2B,E77K,Oncogenic,Loss-of-function,23974956, +MEF2B,N81Y,Oncogenic,Loss-of-function,23974956, +MEF2B,Amplification,Likely Oncogenic,Likely Gain-of-function,26245647, +MEF2B,Y69H,Oncogenic,Loss-of-function,23974956, +MEF2B,D83V,Oncogenic,Gain-of-function,"23974956, 26245647", +CTLA4,T17A,Likely Oncogenic,Likely Loss-of-function,"15018649, 11976786, 20064370, 10082437, 8989248, 18528295, 9459504, 12244107", +ATM,R3008C,Oncogenic,Loss-of-function,"11756177, 23585524, 12149228, 10422797, 10397742", +ATM,E1978*,Likely Oncogenic,Likely Loss-of-function,"21514219, 18807267", +ATM,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,"15928302, 16832357, 16998505", +ATM,D2870A,Likely Oncogenic,Loss-of-function,"9733515, 27304073", +ATM,V2424G,Likely Oncogenic,Loss-of-function,"18634022, 9463314", +ATM,Deletion,Likely Oncogenic,Likely Loss-of-function,"21993670, 16014569", +ATM,D1853N,Likely Neutral,Likely Neutral,"20396981, 18264724, 20799949", +ATM,N2875K,Likely Oncogenic,Loss-of-function,"9733515, 27304073", +NUP93,K442Nfs*,Likely Oncogenic,Likely Loss-of-function,26878725, +NUP93,G591V,Likely Neutral,Neutral,26878725, +NUP93,Exon 13 deletion,Likely Oncogenic,Likely Loss-of-function,26878725, +NUP93,Y629C,Likely Neutral,Neutral,26878725, +MAPK1,Amplification,Likely Oncogenic,Gain-of-function,22961667, +MAPK1,E322K,Likely Oncogenic,Gain-of-function,"24390348, 18813840, 25320010, 26551667, 26181029, 15999996, 21098038, 16324895, 16051177", +CTNNB1,S37F,Likely Oncogenic,Gain-of-function,"9635572, 22815287, 20303878, 9537226, 9065403, 9065402", +CTNNB1,D32A,Likely Oncogenic,Gain-of-function,15829978, +CTNNB1,G34A,Likely Oncogenic,Gain-of-function,"9635572, 15829978, 9065402", +CTNNB1,P44A,Likely Oncogenic,Gain-of-function,"9635572, 18282277, 9065402", +CTNNB1,S37Y,Likely Oncogenic,Gain-of-function,"20606007, 9635572, 9065402", +CTNNB1,K335I,Likely Oncogenic,Gain-of-function,"15579438, 9635572, 24735922, 9065402", +CTNNB1,S37C,Likely Oncogenic,Gain-of-function,"9635572, 9537226, 9065402", +CTNNB1,D32Y,Likely Oncogenic,Gain-of-function,"9635572, 15064718, 9065402", +CTNNB1,G34V,Likely Oncogenic,Gain-of-function,"9635572, 10671680, 9671767, 9065402", +CTNNB1,S45A,Oncogenic,Gain-of-function,12799363, +CTNNB1,W383R,Likely Oncogenic,Gain-of-function,"15579438, 9635572, 9065402", +CTNNB1,S45Y,Likely Oncogenic,Gain-of-function,"9635572, 9065402, 9419974", +CTNNB1,G34E,Likely Oncogenic,Gain-of-function,"9635572, 10671680, 9065402", +CTNNB1,T41A,Oncogenic,Gain-of-function,"9635572, 24735922, 12799363, 9065402", +CTNNB1,S33Y,Oncogenic,Gain-of-function,"9635572, 24735922, 18757411, 9065402", +CTNNB1,D32N,Likely Oncogenic,Gain-of-function,"9635572, 15064718, 9065402", +CTNNB1,N387K,Likely Oncogenic,Gain-of-function,"9635572, 24735922, 9065402", +CTNNB1,D32G,Likely Oncogenic,Gain-of-function,"9635572, 15064718, 9065402", +CTNNB1,S23R,Likely Oncogenic,Gain-of-function,"9635572, 24735922, 18282277, 9065402","Manring et al. Abstract# 2249, AACR 2012 http://cancerres.aacrjournals.org/content/72/8_Supplement/2249" +CTNNB1,S33A,Oncogenic,Gain-of-function,15829978, +CTNNB1,S33C,Oncogenic,Gain-of-function,"9635572, 19582367, 9065402", +CTNNB1,S45P,Likely Oncogenic,Gain-of-function,"9635572, 24735922, 18282277, 9065402","Manring et al. Abstract# 2249, AACR 2012 http://cancerres.aacrjournals.org/content/72/8_Supplement/2249" +CTNNB1,S37A,Likely Oncogenic,Gain-of-function,"15579438, 9635572, 9065402", +CTNNB1,I35S,Likely Oncogenic,Gain-of-function,"12375019, 9635572, 24735922, 18282277, 9065402, 10665646","Manring et al. Abstract# 2249, AACR 2012 http://cancerres.aacrjournals.org/content/72/8_Supplement/2249" +CTNNB1,S33F,Likely Oncogenic,Likely Gain-of-function,"9635572, 15829978, 27543871, 18757411, 19582367, 9065402", +CTNNB1,S45F,Likely Oncogenic,Gain-of-function,"9635572, 18282277, 26686699, 9065402", +CTNNB1,H36P,Likely Oncogenic,Gain-of-function,"9635572, 24735922, 18282277, 9065402","Manring et al. Abstract# 2249, AACR 2012 http://cancerres.aacrjournals.org/content/72/8_Supplement/2249" +CTNNB1,S45del,Likely Oncogenic,Gain-of-function,"9635572, 15064718, 9065402", +MAP2K1,P124Q,Likely Oncogenic,Gain-of-function,25370473, +MAP2K1,K57N,Oncogenic,Gain-of-function,"25351745, 18632602, 26566875", +MAP2K1,G128D,Likely Oncogenic,Gain-of-function,"19915144, 28115009, 25899310", +MAP2K1,F53C,Likely Oncogenic,Likely Gain-of-function,17981815, +MAP2K1,K59del,Likely Oncogenic,Gain-of-function,22389471, +MAP2K1,Q56_V60del,Oncogenic,Gain-of-function,26324360, +MAP2K1,I204T,Likely Oncogenic,Gain-of-function,22327936, +MAP2K1,V211D,Inconclusive,Inconclusive,"19915144, 26399658", +MAP2K1,P387S,Likely Neutral,Likely Neutral,22389471, +MAP2K1,S218D,Likely Oncogenic,Gain-of-function,"17981815, 16439621", +MAP2K1,K97M,Likely Neutral,Loss-of-function,"22177953, 10567369, 16439621", +MAP2K1,K57E,Oncogenic,Gain-of-function,"26566875, 25370473, 24241536", +MAP2K1,L115P,Likely Oncogenic,Likely Gain-of-function,19915144, +MAP2K1,A106T,Likely Neutral,Neutral,25164765, +MAP2K1,F53L,Oncogenic,Gain-of-function,"25351745, 21383288, 22197931, 26582713, 26324360, 24241536", +MAP2K1,L115R,Inconclusive,Inconclusive,19915144, +MAP2K1,V60M,Likely Oncogenic,Gain-of-function,26566875, +MAP2K1,G128V,Likely Oncogenic,Likely Gain-of-function,24265153, +MAP2K1,D65N,Likely Neutral,Likely Neutral,26566875, +MAP2K1,F53S,Likely Oncogenic,Gain-of-function,"17981815, 16439621", +MAP2K1,E144K,Likely Oncogenic,Gain-of-function,26566875, +MAP2K1,I103N,Likely Oncogenic,Gain-of-function,"19915144, 12370306", +MAP2K1,F129L,Likely Oncogenic,Gain-of-function,"21705440, 19915144, 26399658", +MAP2K1,V60E,Likely Oncogenic,Likely Gain-of-function,24265153, +MAP2K1,Y130C,Likely Oncogenic,Gain-of-function,"18060073, 26566875", +MAP2K1,E203K,Oncogenic,Gain-of-function,"25351745, 22197931", +MAP2K1,P306H,Likely Oncogenic,Gain-of-function,22327936, +MAP2K1,R47Q,Oncogenic,Gain-of-function,"24982505, 22327936", +MAP2K1,L37P,Likely Oncogenic,Likely Gain-of-function,26566875, +MAP2K1,N382H,Likely Neutral,Likely Neutral,22197931, +MAP2K1,Q56P,Oncogenic,Gain-of-function,"19915144, 25351745, 22327936, 26566875", +MAP2K1,P124L,Likely Oncogenic,Gain-of-function,"19915144, 25370473", +MAP2K1,E102_I103del,Likely Oncogenic,Gain-of-function,25351745, +MAP2K1,C121S,Likely Oncogenic,Gain-of-function,"24448821, 25351745, 21383288", +MAP2K1,I111N,Inconclusive,Inconclusive,19915144, +MAP2K1,Q58_E62del,Likely Oncogenic,Gain-of-function,26566875, +MAP2K1,H119P,Inconclusive,Inconclusive,19915144, +MAP2K1,S222D,Oncogenic,Gain-of-function,"17981815, 16439621", +MAP2K1,R49L,Oncogenic,Gain-of-function,22327936, +MAP2K1,S123T,Likely Oncogenic,Gain-of-function,26566875, +MAP2K1,E120Q,Likely Neutral,Likely Neutral,26566875, +MAP2K1,T28I,Likely Oncogenic,Likely Gain-of-function,26566875, +MAP2K1,K57T,Likely Oncogenic,Gain-of-function,26644315, +MAP2K1,I111A,Likely Oncogenic,Likely Gain-of-function,12370306, +MAP2K1,D67N,Oncogenic,Gain-of-function,"25351745, 18060073", +MAP2K1,I111R,Likely Oncogenic,Likely Gain-of-function,12370306, +MAP2K1,P124S,Oncogenic,Gain-of-function,"24265153, 22197931, 25370473", +MAP2K1,A52V,Likely Neutral,Neutral,"28115009, 19161339", +MAP2K1,Amplification,Inconclusive,Inconclusive,"26399658, 26684394", +MAP2K1,I111P,Likely Oncogenic,Likely Gain-of-function,12370306, +MAP2K2,S222D,Inconclusive,Inconclusive,16439621, +MAP2K2,F57L,Likely Oncogenic,Likely Gain-of-function,"18042262, 18456719, 16439621", +MAP2K2,F57V,Likely Oncogenic,Likely Gain-of-function,"18042262, 18456719, 16439621", +MAP2K2,N126D,Oncogenic,Gain-of-function,"25487361, 24265153", +MAP2K2,E207K,Oncogenic,Gain-of-function,22197931, +MAP2K2,V35M,Oncogenic,Gain-of-function,"24265153, 21383288", +MAP2K2,L46F,Oncogenic,Gain-of-function,"24265153, 21383288", +MAP2K2,Q60P,Oncogenic,Neutral,"24265154, 24055054", +MAP2K2,C125S,Oncogenic,Gain-of-function,"24265153, 21383288", +MAP2K2,S154F,Likely Neutral,Neutral,27301426, +MAP2K2,K101M,Inconclusive,Inconclusive,"19376813, 22177953, 16439621", +MAP2K2,S226D,Inconclusive,Inconclusive,16439621, +MAP2K2,F57C,Likely Oncogenic,Gain-of-function,16439621, +SPEN,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,26297734, +STAG2,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,"22417201, 21852505, 24121789, 25010205", +IL7R,T244_I245insCPT,Oncogenic,Gain-of-function,21892159, +SOS1,R552G,Likely Oncogenic,Gain-of-function,17143285, +SOS1,R552S,Likely Oncogenic,Gain-of-function,27304678, +SOS1,E846K,Likely Oncogenic,Gain-of-function,"21041952, 17143285", +SOS1,M269R,Likely Oncogenic,Gain-of-function,"27304678, 17143285, 25712082, 24297905", +SOS1,N233Y,Likely Oncogenic,Gain-of-function,27304678, +SOS1,G434R,Likely Oncogenic,Likely Gain-of-function,27304678, +MYC,IGH-MYC Fusion,Oncogenic,Gain-of-function,"10378696, 22333947, 16934487, 19029958, 22464321", +MYC,IGL-MYC Fusion,Oncogenic,Gain-of-function,"10378696, 11034608, 7731690, 8502472, 22333947, 16934487, 19029958, 8816814, 22464321", +MYC,T73A,Likely Oncogenic,Gain-of-function,"10378696, 20399964, 21266350, 18642118, 16934487, 19029958, 10706881, 22464321", +MYC,Amplification,Oncogenic,Gain-of-function,"20164920, 10378696, 16934487, 15083194, 19029958, 22464321", +MYC,Fusions,Likely Oncogenic,Likely Gain-of-function,"22333947, 16934487", +MYC,T73I,Likely Oncogenic,Likely Gain-of-function,"20713710, 26619011, 10825194", +MYC,PVT1-MYC Fusion,Likely Oncogenic,Likely Gain-of-function,"22134537, 24298051", +MYC,IGK-MYC Fusion,Oncogenic,Gain-of-function,"19351371, 10378696, 24957271, 7731690, 8502472, 22333947, 16934487, 21887927, 19029958, 8816814, 19246886, 22464321", +MYC,MYC-nick,Inconclusive,Inconclusive,"24696454, 20691906", +MYCN,Amplification,Oncogenic,Gain-of-function,"12612655, 16116477, 22035742, 22139329, 23091029, 21533284, 15013217, 9214616", +MYCN,P44L,Likely Oncogenic,Likely Gain-of-function,"23334666, 24086065", +SOX9,K398A,Likely Oncogenic,Gain-of-function,15694126, +SOX9,Deletion,Likely Oncogenic,Likely Loss-of-function,"10446171, 12783851, 9002675", +SOX9,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,"10446171, 27248473", +SOX9,H65Y,Likely Oncogenic,Loss-of-function,10446171, +SOX9,L142P,Likely Oncogenic,Loss-of-function,27429045, +SOX9,F12L,Likely Oncogenic,Loss-of-function,10446171, +SOX9,P70R,Likely Oncogenic,Likely Loss-of-function,10446171, +SOX9,A19V,Likely Neutral,Neutral,10446171, +TET2,D1384V,Inconclusive,Inconclusive,24315485, +TET2,R1896M,Likely Oncogenic,Likely Loss-of-function,24315485, +TET2,M1293A,Inconclusive,Inconclusive,24315485, +TET2,R1262A,Likely Neutral,Likely Neutral,24315485, +TET2,K1299E,Inconclusive,Inconclusive,24315485, +TET2,Y1294A,Inconclusive,Inconclusive,24315485, +TET2,N1387A,Likely Oncogenic,Likely Loss-of-function,24315485, +TET2,W1291R,Likely Oncogenic,Likely Loss-of-function,24315485, +TET2,Y1902A,Likely Oncogenic,Likely Loss-of-function,24315485, +TET2,S1303N,Inconclusive,Inconclusive,24315485, +TET2,Deletion,Likely Oncogenic,Loss-of-function,"21625234, 25224413, 21723200, 22017486", +TET2,H1382Y,Inconclusive,Inconclusive,24315485, +TET2,S1290A,Likely Neutral,Likely Neutral,24315485, +TET2,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,"21057493, 24315485", +TET2,Y1295A,Likely Neutral,Likely Neutral,24315485, +TET2,H1904R,Likely Oncogenic,Likely Loss-of-function,24315485, +MYD88,L265P,Oncogenic,Gain-of-function,"25723115, 26111727", +MYD88,M232T,Oncogenic,Gain-of-function,25359991, +MYD88,S243N,Oncogenic,Gain-of-function,"24534189, 2179087", +AGO2,Q545A,Likely Oncogenic,Likely Loss-of-function,17891150, +AGO2,R647A,Likely Oncogenic,Likely Loss-of-function,17891150, +AGO2,A603fs,Likely Oncogenic,Likely Loss-of-function,"20198652, 14749716", +AGO2,R812A,Likely Oncogenic,Likely Loss-of-function,17891150, +AGO2,R583A,Likely Oncogenic,Likely Loss-of-function,17891150, +AGO2,Amplification,Likely Oncogenic,Likely Gain-of-function,"18787018, 23775134", +KMT2B,Truncating Mutations,Inconclusive,Inconclusive,"25998713, 16540515, 17429066", +ATR,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,"10691732, 15282542", +ATRX,Deletion,Likely Oncogenic,Likely Loss-of-function,"21719641, 27311324, 24148618, 26741321, 23904111", +ATRX,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,"21719641, 8968741, 24148618, 15591283, 14592816, 18409179, 17609377", +CDK12,G909R,Likely Oncogenic,Loss-of-function,"24554720, 25712099", +CDK12,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,"24554720, 21720365, 25712099, 26787825", +CDK12,Deletion,Likely Oncogenic,Likely Loss-of-function,"24554720, 25712099, 24240700", +CDK12,L996F,Likely Oncogenic,Loss-of-function,"24554720, 21720365, 25712099", +CDK12,Amplification,Inconclusive,Inconclusive,"20932292, 26658019, 21097718", +CDK12,W719*,Likely Oncogenic,Loss-of-function,"24554720, 25712099", +CDK12,K765R,Likely Oncogenic,Likely Loss-of-function,"24554720, 25712099", +CDK12,R882L,Likely Oncogenic,Loss-of-function,"24554720, 21720365, 25712099", +CDK12,D887N,Likely Oncogenic,Likely Loss-of-function,24554720, +CDK12,K975E,Likely Neutral,Likely Neutral,"24554720, 21720365, 25712099", +CDK12,Y901C,Likely Oncogenic,Loss-of-function,"24554720, 21720365, 25712099", +AXL,Amplification,Likely Oncogenic,Likely Gain-of-function,"23264849, 22751098, 25337673, 25966280", +MYOD1,L122R,Oncogenic,Likely Gain-of-function,"24793135, 1329087", +B2M,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,"25594174, 25294904, 22833104, 16730261, 22137796, 23784959, 9637706, 1898655", +B2M,M1I,Likely Oncogenic,Loss-of-function,"11894933, 24947018", +B2M,M1T,Likely Oncogenic,Loss-of-function,22137796, +B2M,M1K,Likely Oncogenic,Loss-of-function,"24947018, 22137796", +B2M,M1V,Likely Oncogenic,Loss-of-function,24947018, +B2M,M1R,Likely Oncogenic,Loss-of-function,22137796, +B2M,Deletion,Likely Oncogenic,Likely Loss-of-function,"25594174, 25294904, 22833104, 16730261, 22137796, 23784959, 9637706, 1898655", +SRC,Q531*,Likely Oncogenic,Gain-of-function,9988270, +SRC,Amplification,Likely Oncogenic,Likely Gain-of-function,"24788409, 11114744, 15060621, 22589274","Zehir A et al. Nature Medicine, 2017 http://doi:10.1038/nm.4333" +GATA3,Deletion,Likely Oncogenic,Likely Loss-of-function,"10935639, 15361840, 23426732, 26637396, 24758297, 7829479", +GATA3,R177Pfs*126,Likely Oncogenic,Loss-of-function,26268891, +GATA3,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,"23426732, 18242514, 26637396, 27588951, 24758297", +GATA3,Amplification,Likely Oncogenic,Likely Gain-of-function,"20154722, 11441075, 18471881, 16087702, 24448324, 20855495, 21779441", +BARD1,Deletion,Likely Oncogenic,Likely Loss-of-function,"20029420, 17848578, 20842729", +BARD1,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,"20029420, 8944023", +CCND1,L283_D294del,Likely Oncogenic,Likely Gain-of-function,"9832503, 16732330", +CCND1,256_286trunc,Likely Oncogenic,Gain-of-function,"17299095, 9832503, 16732330, 9926916", +CCND1,P287A,Likely Oncogenic,Gain-of-function,"16732330, 12615961", +CCND1,P287T,Oncogenic,Gain-of-function,"9832503, 16732330, 12955092", +CCND1,T286I,Oncogenic,Gain-of-function,"9832503, 16732330, 11124803", +CCND1,Amplification,Oncogenic,Gain-of-function,"9832503, 20164920, 20074063, 8114739, 10508165, 11486031, 16393691, 9792703, 19020303, 21734724", +CCND1,C47S,Likely Oncogenic,Gain-of-function,"24145436, 27713153", +CCND1,Truncating Mutations,Likely Oncogenic,Likely Gain-of-function,"28483394, 19823025", +CCND1,P287S,Likely Oncogenic,Likely Gain-of-function,"16732330, 12955092, 12615961", +CCND1,D289del,Oncogenic,Gain-of-function,"9832503, 16732330", +CCND1,D289_D292del,Likely Oncogenic,Likely Gain-of-function,"9832503, 16732330", +CCND1,CCND1-IGH Fusion,Likely Oncogenic,Gain-of-function,"14514791, 25596256, 16690963, 16402392", +CCND1,Y44D,Likely Oncogenic,Gain-of-function,"24145436, 27713153", +CCND1,T286A,Oncogenic,Gain-of-function,"16732330, 11124803", +BCL2,IGH-BCL2 Fusion,Oncogenic,Gain-of-function,"23939148, 3500184, 18202696, 3874430, 10910891, 2875799, 23892979", +KEAP1,V155F,Oncogenic,Loss-of-function,24322982, +KEAP1,G186R,Oncogenic,Loss-of-function,24322982, +KEAP1,Deletion,Likely Oncogenic,Likely Loss-of-function,"17020408, 24142871", +KEAP1,R415G,Oncogenic,Loss-of-function,18316592, +KEAP1,G480W,Likely Oncogenic,Likely Loss-of-function,24322982, +KEAP1,R320Q,Oncogenic,Loss-of-function,24322982, +KEAP1,S243C,Oncogenic,Loss-of-function,24322982, +KEAP1,R470C,Oncogenic,Loss-of-function,24322982, +KEAP1,G430C,Oncogenic,Loss-of-function,18316592, +KEAP1,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,"17020408, 24142871, 24322982", +KEAP1,G333S,Oncogenic,Loss-of-function,23912815, +KEAP1,G423V,Oncogenic,Loss-of-function,24322982, +KEAP1,R272C,Oncogenic,Loss-of-function,18316592, +KEAP1,C23Y,Likely Oncogenic,Loss-of-function,17822677, +KEAP1,D422N,Oncogenic,Loss-of-function,24322982, +KEAP1,G333C,Oncogenic,Loss-of-function,19818716, +PTCH1,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,8782823, +PTCH1,R571W,Likely Neutral,Likely Neutral,24368541, +PTEN,F347L,Oncogenic,Loss-of-function,10866302, +PTEN,T131A,Oncogenic,Loss-of-function,21828076, +PTEN,S227F,Likely Oncogenic,Loss-of-function,10866302, +PTEN,R173P,Likely Oncogenic,Loss-of-function,10866302, +PTEN,G251C,Likely Oncogenic,Loss-of-function,10866302, +PTEN,N276S,Likely Oncogenic,Loss-of-function,25527629, +PTEN,D92G,Oncogenic,Loss-of-function,21828076, +PTEN,C124N,Oncogenic,Loss-of-function,21828076, +PTEN,T131I,Oncogenic,Loss-of-function,21828076, +PTEN,V217D,Oncogenic,Loss-of-function,21828076, +PTEN,Y174N,Likely Oncogenic,Loss-of-function,10866302, +PTEN,L325F,Oncogenic,Loss-of-function,19329485, +PTEN,R15K,Oncogenic,Loss-of-function,21828076, +PTEN,L112P,Oncogenic,Loss-of-function,"25527629, 10866302", +PTEN,A121V,Likely Neutral,Neutral,21828076, +PTEN,V343L,Oncogenic,Loss-of-function,21828076, +PTEN,I33del,Likely Oncogenic,Loss-of-function,"24904117, 10560660, 22817889, 9326929, 24293293", +PTEN,G20E,Likely Oncogenic,Loss-of-function,"17213812, 10866302", +PTEN,K342N,Likely Oncogenic,Loss-of-function,10866302, +PTEN,D331G,Likely Oncogenic,Loss-of-function,10866302, +PTEN,D326N,Oncogenic,Loss-of-function,"21828076, 25527629", +PTEN,V369G,Likely Neutral,Neutral,"21828076, 10866302", +PTEN,S10N,Likely Oncogenic,Loss-of-function,10866302, +PTEN,K289E,Likely Oncogenic,Loss-of-function,10866302, +PTEN,S362L,Likely Neutral,Likely Neutral,19329485, +PTEN,T131L,Oncogenic,Loss-of-function,21828076, +PTEN,N94I,Oncogenic,Loss-of-function,21828076, +PTEN,P95L,Oncogenic,Loss-of-function,21828076, +PTEN,P38L,Likely Oncogenic,Likely Loss-of-function,23039341, +PTEN,G36R,Oncogenic,Loss-of-function,21828076, +PTEN,Y16C,Likely Oncogenic,Loss-of-function,10866302, +PTEN,M199del,Oncogenic,Loss-of-function,11051241, +PTEN,C124S,Likely Oncogenic,Loss-of-function,"25527629, 9811831", +PTEN,Y27S,Likely Oncogenic,Loss-of-function,10866302, +PTEN,D92H,Oncogenic,Loss-of-function,21828076, +PTEN,D252G,Oncogenic,Loss-of-function,25527629, +PTEN,H93R,Oncogenic,Loss-of-function,21828076, +PTEN,S170R,Oncogenic,Loss-of-function,"9467011, 10866302", +PTEN,T401I,Likely Oncogenic,Loss-of-function,10866302, +PTEN,R15S,Oncogenic,Gain-of-function,17213812, +PTEN,M134L,Likely Oncogenic,Loss-of-function,10866302, +PTEN,L23F,Oncogenic,Loss-of-function,17213812, +PTEN,D162G,Oncogenic,Loss-of-function,21828076, +PTEN,K125E,Oncogenic,Loss-of-function,"20926450, 21828076", +PTEN,A126S,Oncogenic,Loss-of-function,21828076, +PTEN,N48K,Oncogenic,Loss-of-function,"21828076, 25527629", +PTEN,I122L,Oncogenic,Loss-of-function,21828076, +PTEN,D92V,Oncogenic,Loss-of-function,21828076, +PTEN,D92A,Oncogenic,Loss-of-function,21828076, +PTEN,D92E,Oncogenic,Loss-of-function,21828076, +PTEN,S170N,Likely Oncogenic,Loss-of-function,10866302, +PTEN,R173C,Likely Oncogenic,Loss-of-function,10866302, +PTEN,Q110R,Likely Neutral,Likely Neutral,19329485, +PTEN,M35R,Oncogenic,Loss-of-function,21828076, +PTEN,R130G,Oncogenic,Loss-of-function,"21828076, 25527629, 11051241, 10866302, 9811831", +PTEN,H123Q,Oncogenic,Loss-of-function,21828076, +PTEN,D24Y,Oncogenic,Loss-of-function,17213812, +PTEN,G127E,Oncogenic,Loss-of-function,21828076, +PTEN,P95S,Oncogenic,Loss-of-function,19329485, +PTEN,K128T,Oncogenic,Loss-of-function,21828076, +PTEN,E157G,Oncogenic,Loss-of-function,21828076, +PTEN,F154L,Oncogenic,Loss-of-function,19329485, +PTEN,F241S,Oncogenic,Loss-of-function,"21828076, 25527629", +PTEN,H93Q,Oncogenic,Loss-of-function,21828076, +PTEN,L345Q,Likely Oncogenic,Loss-of-function,10866302, +PTEN,T167A,Oncogenic,Loss-of-function,21828076, +PTEN,I122V,Likely Neutral,Neutral,21828076, +PTEN,K125M,Oncogenic,Loss-of-function,21828076, +PTEN,I122S,Oncogenic,Loss-of-function,21828076, +PTEN,R159G,Likely Oncogenic,Loss-of-function,17942903, +PTEN,H118P,Oncogenic,Loss-of-function,"21828076, 25527629", +PTEN,C124R,Oncogenic,Loss-of-function,"9467011, 21828076, 10866302", +PTEN,A126G,Oncogenic,Loss-of-function,21828076, +PTEN,R130Q,Likely Oncogenic,Loss-of-function,10866302, +PTEN,G129A,Likely Oncogenic,Likely Loss-of-function,"21828076, 26619011", +PTEN,T160I,Oncogenic,Loss-of-function,21828076, +PTEN,Y68H,Likely Oncogenic,Loss-of-function,"23840064, 9467011, 10866302", +PTEN,A121P,Likely Oncogenic,Loss-of-function,10866302, +PTEN,G127N,Oncogenic,Loss-of-function,21828076, +PTEN,A126V,Oncogenic,Loss-of-function,21828076, +PTEN,T131S,Likely Neutral,Neutral,21828076, +PTEN,K125R,Likely Neutral,Neutral,21828076, +PTEN,D24N,Likely Oncogenic,Likely Loss-of-function,17213812, +PTEN,F21A,Likely Oncogenic,Loss-of-function,17213812, +PTEN,R335L,Oncogenic,Loss-of-function,21828076, +PTEN,H61R,Likely Oncogenic,Loss-of-function,10866302, +PTEN,C136Y,Oncogenic,Loss-of-function,10866302, +PTEN,G165R,Likely Oncogenic,Loss-of-function,10866302, +PTEN,R161G,Oncogenic,Loss-of-function,21828076, +PTEN,H93D,Oncogenic,Loss-of-function,21828076, +PTEN,G129D,Oncogenic,Loss-of-function,21828076, +PTEN,G165E,Oncogenic,Loss-of-function,21828076, +PTEN,L181P,Oncogenic,Loss-of-function,21828076, +PTEN,D301N,Likely Neutral,Likely Neutral,19329485, +PTEN,I168F,Oncogenic,Loss-of-function,21828076, +PTEN,H123Y,Oncogenic,Loss-of-function,21828076, +PTEN,Y155C,Oncogenic,Loss-of-function,"21828076, 11051241, 10866302", +PTEN,P96Q,Oncogenic,Loss-of-function,21828076, +PTEN,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,"17218262, 11237521", +PTEN,R130*,Oncogenic,Loss-of-function,24721394, +PTEN,T319del,Oncogenic,Loss-of-function,10468583, +PTEN,K125L,Oncogenic,Loss-of-function,21828076, +PTEN,K128Q,Oncogenic,Loss-of-function,25447541, +PTEN,A34D,Oncogenic,Loss-of-function,21828076, +PTEN,P169H,Oncogenic,Loss-of-function,21828076, +PTEN,G44D,Oncogenic,Loss-of-function,21828076, +PTEN,Y68D,Oncogenic,Loss-of-function,21828076, +PTEN,L42R,Likely Oncogenic,Loss-of-function,10866302, +PTEN,K62R,Oncogenic,Loss-of-function,"20926450, 19457929", +PTEN,H123D,Oncogenic,Loss-of-function,21828076, +PTEN,A121E,Oncogenic,Loss-of-function,21828076, +PTEN,L112R,Oncogenic,Loss-of-function,10866302, +PTEN,A39P,Oncogenic,Loss-of-function,25527629, +PTEN,F341V,Oncogenic,Loss-of-function,"11051241, 10866302", +PTEN,D162H,Oncogenic,Loss-of-function,23840064, +PTEN,D92N,Likely Oncogenic,Loss-of-function,21828076, +PTEN,Deletion,Oncogenic,Loss-of-function,"12844284, 9697695, 12370746, 21430697", +PTEN,T319A,Likely Oncogenic,Likely Loss-of-function,26166433, +PTEN,R173H,Oncogenic,Loss-of-function,"10866302, 24721394", +PTEN,R130L,Oncogenic,Loss-of-function,"9467011, 25527629, 10866302", +PTEN,G129E,Oncogenic,Loss-of-function,"9467011, 21828076, 25527629, 10866302, 9811831", +PTEN,K128N,Oncogenic,Loss-of-function,21828076, +PTEN,C136R,Likely Oncogenic,Loss-of-function,23475934, +PTEN,K128R,Oncogenic,Loss-of-function,21828076, +PTEN,G165V,Oncogenic,Loss-of-function,"9467011, 21828076", +PTEN,H93Y,Oncogenic,Loss-of-function,"21828076, 10866302", +PTEN,H61D,Oncogenic,Loss-of-function,21828076, +PTEN,G129R,Oncogenic,Loss-of-function,"21828076, 25527629, 10866302, 9811831", +PTEN,Y65C,Oncogenic,Loss-of-function,"20926450, 19457929", +PTEN,C71Y,Oncogenic,Loss-of-function,"11051241, 10866302", +PTEN,C105F,Likely Oncogenic,Loss-of-function,10866302, +PTEN,R335*,Oncogenic,Loss-of-function,23475934, +PTEN,L108P,Likely Oncogenic,Loss-of-function,25527629, +PTEN,V133I,Likely Oncogenic,Loss-of-function,10866302, +PTEN,V343E,Oncogenic,Loss-of-function,10866302, +PTEN,R130K,Oncogenic,Loss-of-function,21828076, +PTEN,D107Y,Likely Oncogenic,Loss-of-function,10866302, +PTEN,A126D,Oncogenic,Loss-of-function,21828076, +PTEN,R130A,Oncogenic,Loss-of-function,21828076, +PTEN,I32del,Likely Oncogenic,Loss-of-function,"24904117, 10560660, 22817889, 9326929, 24293293", +BCOR,BCOR-RARA Fusion,Oncogenic,Likely Switch-of-function,20807888, +BCOR,ZC3H7B-BCOR Fusion,Oncogenic,Likely Switch-of-function,23580382, +BCOR,Fusions,Likely Oncogenic,Likely Switch-of-function,24515802, +BCOR,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,"26847029, 25550361, 22237022, 22012066, 24047651", +BCOR,BCOR-CCNB3 Fusion,Oncogenic,Likely Switch-of-function,22387997, +BCOR,Deletion,Likely Oncogenic,Likely Loss-of-function,"26847029, 10582652, 2212066", +RNF43,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,"23847203, 23096461, 25344691", +CIC,R201W,Likely Oncogenic,Likely Loss-of-function,22072542, +CIC,Fusions,Likely Oncogenic,Likely Loss-of-function,"22072439, 25007147, 28188754", +CIC,R1515H,Likely Oncogenic,Likely Loss-of-function,22072542, +CIC,CIC-DUX4 Fusion,Oncogenic,Switch-of-function,"22072439, 16717057", +CIC,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,"22072542, 22588899, 21817013, 24117486, 24086756", +INPP4B,Deletion,Likely Oncogenic,Likely Loss-of-function,"25883023, 25428846, 19647222, 21127264", +INPP4B,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,"25428846, 19647222, 21127264", +STAT3,Y640F,Oncogenic,Gain-of-function,"25586472, 25873174, 22591296", +STAT3,F384V,Likely Oncogenic,Likely Gain-of-function,"22751495, 17881745, 17676033, 18602572, 26619011", +STAT3,S614R,Likely Oncogenic,Gain-of-function,"25586472, 25709890", +STAT3,F384L,Likely Oncogenic,Likely Gain-of-function,"22751495, 17881745, 17676033, 18602572, 26619011", +STAT3,F384Y,Likely Oncogenic,Likely Gain-of-function,"22751495, 17881745, 17676033, 18602572, 26619011", +STAT3,H410R,Likely Oncogenic,Gain-of-function,26419508, +STAT3,D661Y,Likely Oncogenic,Gain-of-function,25586472, +STAT3,D661V,Likely Oncogenic,Gain-of-function,22591296, +WHSC1L1,Amplification,Inconclusive,Inconclusive,"18757432, 24874471, 21664949", +PRDM1,P48T,Likely Oncogenic,Loss-of-function,21156281, +PRDM1,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,"20651244, 27568520, 16424392, 21156281, 16492805", +PRDM1,Deletion,Likely Oncogenic,Likely Loss-of-function,"27568520, 16424392, 21156281, 16492805", +PRDM1,Y149D,Likely Oncogenic,Loss-of-function,21156281, +PRDM1,C569Y,Likely Oncogenic,Loss-of-function,21156281, +PRDM1,P48R,Likely Oncogenic,Loss-of-function,21156281, +JAK1,A723D,Likely Oncogenic,Gain-of-function,24735922, +JAK1,F958C,Oncogenic,Gain-of-function,21393331, +JAK1,G1079D,Likely Oncogenic,Gain-of-function,25873174, +JAK1,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,24154688, +JAK1,S729C,Oncogenic,Gain-of-function,23788652, +JAK1,F958S,Oncogenic,Gain-of-function,21393331, +JAK1,V658F,Oncogenic,Gain-of-function,"20868368, 19139102, 21393331", +JAK1,K1026E,Oncogenic,Gain-of-function,20868368, +JAK1,L783F,Oncogenic,Gain-of-function,21393331, +JAK1,L910P,Oncogenic,Gain-of-function,"20868368, 25873174, 23788652", +JAK1,A634D,Oncogenic,Gain-of-function,19139102, +JAK1,Y1035C,Oncogenic,Gain-of-function,20868368, +JAK1,R879C,Oncogenic,Gain-of-function,18362171, +JAK1,S703I,Oncogenic,Gain-of-function,"24825865, 23788652", +JAK1,F958V,Oncogenic,Gain-of-function,21393331, +JAK1,G871E,Likely Oncogenic,Likely Loss-of-function,16474838, +JAK1,S646F,Oncogenic,Gain-of-function,19470474, +JAK1,R724H,Oncogenic,Gain-of-function,18362171, +JAK1,K648N,Likely Oncogenic,Gain-of-function,21551237, +JAK1,Y652H,Likely Oncogenic,Gain-of-function,21551237, +JAK2,R683S,Oncogenic,Gain-of-function,"18805579, 23748007, 23452118", +JAK2,L1026F,Inconclusive,Inconclusive,26419724, +JAK2,BCR-JAK2 Fusion,Oncogenic,Gain-of-function,"25664618, 22549126, 22384256, 25789185, 23904814, 18537978, 16001431, 24913195, 18503828", +JAK2,TEL-JAK2 Fusion,Oncogenic,Gain-of-function,"22733019, 10706877, 9360930, 15676212, 10845925", +JAK2,V617F,Oncogenic,Gain-of-function,"12351625, 15793561, 21533163, 19543316", +JAK2,L611V,Likely Oncogenic,Likely Gain-of-function,20182460, +JAK2,Amplification,Oncogenic,Gain-of-function,20628145, +JAK2,C618R,Oncogenic,Gain-of-function,22960131, +JAK2,L551P,Inconclusive,Inconclusive,26419724, +JAK2,S1025C,Inconclusive,Inconclusive,26419724, +JAK2,V1075F,Inconclusive,Inconclusive,26419724, +JAK2,R683T,Inconclusive,Inconclusive,26419724, +JAK2,W1038C,Inconclusive,Inconclusive,26419724, +JAK2,SSBP2-JAK2 Fusion,Likely Oncogenic,Likely Gain-of-function,"21325169, 18618714", +JAK2,Y1045*,Inconclusive,Inconclusive,26419724, +JAK2,Y1045W,Inconclusive,Inconclusive,26419724, +JAK2,H538Q,Oncogenic,Gain-of-function,17267906, +JAK2,PCM1-JAK2 Fusion,Likely Oncogenic,Gain-of-function,"16034466, 21325169, 23372669, 15805263, 16424865, 24913195", +JAK2,R683K,Oncogenic,Gain-of-function,"18805579, 23748007, 23452118", +JAK2,F1061W,Inconclusive,Inconclusive,26419724, +JAK2,T875N,Oncogenic,Gain-of-function,"20585391, 16804112, 19543316, 21362419", +JAK2,PAX5-JAK2 Fusion,Oncogenic,Gain-of-function,"25207766, 25515960", +JAK2,R277K,Inconclusive,Inconclusive,26419724, +JAK2,K539L,Oncogenic,Gain-of-function,"20585391, 17267906, 21362419", +JAK2,N542_E543del,Oncogenic,Gain-of-function,17267906, +JAK2,G417P,Inconclusive,Inconclusive,26419724, +JAK2,D544H,Inconclusive,Inconclusive,26419724, +JAK2,S1039F,Inconclusive,Inconclusive,26419724, +JAK2,F537_K539delinsL,Oncogenic,Gain-of-function,17267906, +JAK2,SPAG9-JAK2 Fusion,Likely Oncogenic,Likely Gain-of-function,"25515960, 25951811", +JAK2,R683G,Oncogenic,Gain-of-function,"18805579, 20585391, 23748007, 23452118", +JAK2,Fusions,Likely Oncogenic,Likely Gain-of-function,"25207766, 24913195", +JAK2,ATF7IP-JAK2 Fusion,Oncogenic,Gain-of-function,25207766, +JAK2,L983F,Inconclusive,Inconclusive,26419724, +JAK2,Y931C,Inconclusive,Inconclusive,26419724, +JAK2,I1018F,Inconclusive,Inconclusive,26419724, +JAK2,I1018W,Inconclusive,Inconclusive,26419724, +AURKA,Amplification,Oncogenic,Gain-of-function,"9606188, 9771714, 10914715", +AURKA,K162D,Likely Neutral,Loss-of-function,"12237287, 25395580", +AURKA,F31I,Likely Oncogenic,Gain-of-function,"12881723, 12208850", +STK11,R304W,Oncogenic,Loss-of-function,"9837816, 12552571", +STK11,D176N,Likely Oncogenic,Loss-of-function,"9837816, 15987703", +STK11,H174R,Likely Oncogenic,Loss-of-function,25960268, +STK11,D194Y,Likely Oncogenic,Loss-of-function,26917230, +STK11,K78A,Likely Oncogenic,Loss-of-function,"15800014, 14668798", +STK11,F354L,Likely Neutral,Likely Neutral,"15800014, 10676634", +STK11,Deletion,Likely Oncogenic,Likely Loss-of-function,"16582077, 21532627, 1627113, 19892943", +STK11,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,"24652667, 21516316, 19340305, 19892943, 25079552", +STK11,L67P,Likely Oncogenic,Loss-of-function,"9837816, 15987703", +STK11,W308C,Likely Oncogenic,Loss-of-function,"9837816, 15987703", +STK11,M136R,Likely Oncogenic,Loss-of-function,14668798, +STK11,A205T,Oncogenic,Loss-of-function,16407837, +STK11,I177N,Oncogenic,Loss-of-function,12552571, +STK11,K78I,Likely Oncogenic,Loss-of-function,9837816, +STK11,G163D,Likely Oncogenic,Loss-of-function,"9887330, 14668798, 10430928, 9605748", +JUN,Amplification,Oncogenic,Gain-of-function,"19449367, 17418412", +PTPN11,K590R,Likely Neutral,Likely Switch-of-function,25823821, +PTPN11,Y63C,Likely Oncogenic,Gain-of-function,15834506, +PTPN11,R498W,Likely Oncogenic,Likely Loss-of-function,"17053061, 24891296", +PTPN11,Q510E,Likely Oncogenic,Likely Loss-of-function,"25359717, 21803945, 22058153", +PTPN11,M504V,Oncogenic,Gain-of-function,15834506, +PTPN11,D61Y,Oncogenic,Gain-of-function,"15834506, 12717436", +PTPN11,A72V,Oncogenic,Gain-of-function,15834506, +PTPN11,N308D,Oncogenic,Gain-of-function,"14974085, 15834506, 12717436", +PTPN11,G503V,Likely Oncogenic,Likely Gain-of-function,15834506, +PTPN11,T507K,Oncogenic,Gain-of-function,"15604238, 18286234", +PTPN11,Deletion,Oncogenic,Loss-of-function,22869052, +PTPN11,E76A,Oncogenic,Gain-of-function,"15834506, 12717436", +PTPN11,P491S,Likely Oncogenic,Likely Gain-of-function,24891296, +PTPN11,V45L,Likely Oncogenic,Gain-of-function,15604238, +PTPN11,Q79R,Likely Oncogenic,Likely Gain-of-function,15834506, +PTPN11,F71I,Oncogenic,Gain-of-function,15834506, +PTPN11,S502T,Likely Oncogenic,Gain-of-function,15834506, +PTPN11,E76K,Oncogenic,Gain-of-function,"15834506, 12717436", +PTPN11,D61N,Oncogenic,Gain-of-function,15834506, +PTPN11,T468M,Oncogenic,Loss-of-function,"26742426, 16358218, 25288766", +PTPN11,A72S,Oncogenic,Gain-of-function,14974085, +PTPN11,Y62C,Likely Oncogenic,Gain-of-function,15604238, +PTPN11,E69K,Likely Oncogenic,Likely Gain-of-function,"15604238, 12717436", +PTPN11,R498L,Inconclusive,Inconclusive,24935154, +PTPN11,E139D,Likely Oncogenic,Likely Gain-of-function,16358218, +PTPN11,G464A,Inconclusive,Inconclusive,24935154, +PTPN11,I282V,Oncogenic,Gain-of-function,"14974085, 15834506", +PTPN11,D106A,Oncogenic,Gain-of-function,18286234, +PTPN11,T73I,Oncogenic,Gain-of-function,15834506, +NF1,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,"8052307, 26345759, 19573811, 8563751, 23913538, 7542586, 7655472, 10862084, 24576830, 23047742, 10543400, 12509763, 14722914", +NF1,L1301R,Likely Oncogenic,Loss-of-function,"8052307, 19573811, 24576830, 12509763, 8563751, 22807134, 7542586", +NF1,Deletion,Likely Oncogenic,Loss-of-function,"23460398, 8052307, 19573811, 24576830, 12509763, 8563751, 19767589, 7542586, 20513137", +NF1,R1276P,Oncogenic,Loss-of-function,"9302992, 9219684, 9668168", +NF1,K1436Q,Likely Oncogenic,Loss-of-function,"8052307, 19573811, 24576830, 12509763, 8563751, 22807134, 7542586", +NF1,R1391S,Likely Oncogenic,Loss-of-function,"8052307, 19573811, 24576830, 9003501, 12509763, 8563751, 7542586", +NF1,K1423E,Oncogenic,Loss-of-function,"8052307, 19573811, 24576830, 12509763, 8563751, 1568247, 7542586", +NF1,S1463F,Likely Oncogenic,Loss-of-function,"8052307, 19573811, 24576830, 12509763, 8563751, 22807134, 7542586, 22108604", +NF1,R1204G,Likely Oncogenic,Loss-of-function,"8052307, 19573811, 24576830, 12509763, 8563751, 22807134, 7542586", +NF1,E1356G,Likely Oncogenic,Loss-of-function,"8052307, 19573811, 24576830, 12509763, 8563751, 22807134, 7542586", +NF1,V1398D,Likely Oncogenic,Loss-of-function,"8052307, 19573811, 24576830, 12509763, 8563751, 22807134, 7542586", +NF1,T1324N,Likely Oncogenic,Loss-of-function,"8052307, 19573811, 24576830, 12509763, 8563751, 22807134, 7542586", +NF1,R1204W,Likely Oncogenic,Loss-of-function,"8052307, 19573811, 24576830, 12509763, 8563751, 22807134, 7542586", +NF1,R1391G,Likely Oncogenic,Loss-of-function,"8052307, 19573811, 24576830, 12509763, 8563751, 22807134, 7542586", +NF1,Y489C,Oncogenic,Loss-of-function,11258625, +NF1,R2450*,Likely Oncogenic,Likely Loss-of-function,23288408, +NF1,R1276Q,Likely Oncogenic,Loss-of-function,"8052307, 19573811, 24576830, 12509763, 8563751, 22807134, 7542586", +FOXL2,Amplification,Inconclusive,Inconclusive,21623383, +FOXL2,C134W,Likely Oncogenic,Loss-of-function,"24342437, 24817949, 23372819", +PTPRD,G446E,Likely Oncogenic,Likely Loss-of-function,"19074898, 25113440, 8393854", +PTPRD,Deletion,Oncogenic,Loss-of-function,"19478061, 19074898, 26267899", +PTPRD,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,"19478061, 25113440", +PTPRD,V1565I,Likely Oncogenic,Likely Loss-of-function,19074898, +PTPRD,P1311T,Likely Oncogenic,Likely Loss-of-function,"19478061, 26267899", +PTPRD,R1088C,Likely Oncogenic,Likely Loss-of-function,19478061, +BRCA1,S1297del,Likely Neutral,Likely Neutral,23867111, +BRCA1,M1663L,Likely Neutral,Likely Neutral,20516115, +BRCA1,S1512I,Likely Neutral,Likely Neutral,"18680205, 15689452", +BRCA1,E1250K,Likely Neutral,Likely Neutral,23867111, +BRCA1,I89T,Inconclusive,Inconclusive,"22034435, 16403807", +BRCA1,M1R,Likely Oncogenic,Likely Loss-of-function,21922593, +BRCA1,A1669S,Likely Neutral,Likely Neutral,"15172985, 20516115, 11157798", +BRCA1,G1738E,Likely Oncogenic,Loss-of-function,"15172985, 10811118, 20516115, 17308087, 11157798", +BRCA1,E33A,Likely Oncogenic,Likely Loss-of-function,21922593, +BRCA1,E1644G,Likely Neutral,Likely Neutral,17308087, +BRCA1,T1720I,Likely Neutral,Likely Neutral,15004537, +BRCA1,A1708E,Oncogenic,Loss-of-function,"15172985, 23867111, 8751436, 11573086, 15923272, 8942979, 20516115, 21922593, 11157798, 9159158, 7939630", +BRCA1,C1767S,Likely Neutral,Likely Neutral,23867111, +BRCA1,P142H,Likely Neutral,Neutral,"23867111, 23161852", +BRCA1,C64G,Likely Oncogenic,Loss-of-function,"20103620, 23867111, 22034435, 10635334, 23161852, 16403807", +BRCA1,P1771R,Likely Neutral,Likely Neutral,20516115, +BRCA1,P1812S,Inconclusive,Inconclusive,15172985, +BRCA1,E1660G,Likely Oncogenic,Likely Loss-of-function,"15172985, 12496477", +BRCA1,M1775K,Likely Oncogenic,Loss-of-function,"15172985, 18285836, 11573086, 8942979, 20516115", +BRCA1,M1400V,Inconclusive,Inconclusive,"23867111, 19369211, 16793542, 15770685", +BRCA1,N1819S,Likely Neutral,Likely Neutral,"15172985, 20516115", +BRCA1,F1761I,Likely Oncogenic,Likely Loss-of-function,"15172985, 10811118", +BRCA1,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,"12483515, 11358863, 20608970, 12947386", +BRCA1,H1402Y,Likely Neutral,Likely Neutral,15689452, +BRCA1,M1775E,Likely Oncogenic,Likely Loss-of-function,"15172985, 11573086, 8942979", +BRCA1,N550H,Likely Neutral,Likely Neutral,18680205, +BRCA1,M1689R,Likely Oncogenic,Likely Loss-of-function,"15172985, 20516115", +BRCA1,S1651P,Inconclusive,Inconclusive,23867111, +BRCA1,A1843P,Likely Oncogenic,Likely Loss-of-function,"15172985, 11595708, 20516115", +BRCA1,Q1756C,Likely Oncogenic,Likely Loss-of-function,8942979, +BRCA1,E1586G,Likely Neutral,Likely Neutral,23613828, +BRCA1,T231M,Likely Neutral,Likely Neutral,23867111, +BRCA1,E362H,Likely Neutral,Likely Neutral,23867111, +BRCA1,A1789T,Oncogenic,Loss-of-function,"23867111, 18680205", +BRCA1,N132K,Likely Neutral,Neutral,"23867111, 18680205, 23161852", +BRCA1,V1810G,Likely Oncogenic,Likely Loss-of-function,"15004537, 15172985, 20516115", +BRCA1,S1101N,Likely Neutral,Likely Neutral,23867111, +BRCA1,F1662S,Likely Neutral,Likely Neutral,20516115, +BRCA1,G1738R,Likely Oncogenic,Loss-of-function,"15172985, 20516115, 17308087", +BRCA1,E29V,Inconclusive,Inconclusive,"22034435, 16403807", +BRCA1,L1780P,Likely Oncogenic,Loss-of-function,"15172985, 10811118, 20516115", +BRCA1,V1736A,Likely Oncogenic,Loss-of-function,"15004537, 15172985, 23867111, 20516115, 17308087", +BRCA1,L1564P,Likely Oncogenic,Likely Loss-of-function,17308087, +BRCA1,D1733G,Likely Neutral,Likely Neutral,"15172985, 10811118, 17161371, 20516115, 11157798", +BRCA1,R133H,Likely Neutral,Neutral,23161852, +BRCA1,S4F,Inconclusive,Inconclusive,23867111, +BRCA1,E1794D,Likely Neutral,Likely Neutral,"23867111, 20516115, 17308087", +BRCA1,V1741G,Likely Oncogenic,Likely Loss-of-function,"12497638, 15172985, 20516115", +BRCA1,R1699W,Oncogenic,Loss-of-function,"15172985, 23867111, 11573086, 12496476, 20516115, 11157798, 7939630", +BRCA1,K50E,Inconclusive,Inconclusive,"22034435, 16403807", +BRCA1,Y1853*,Oncogenic,Loss-of-function,"15004537, 14729053, 8942979, 15569676, 21922593", +BRCA1,I68K,Inconclusive,Inconclusive,"22034435, 16403807", +BRCA1,V1809F,Likely Oncogenic,Likely Loss-of-function,"15172985, 15689452, 20516115", +BRCA1,M1689T,Likely Oncogenic,Likely Loss-of-function,20516115, +BRCA1,V1838E,Likely Oncogenic,Likely Loss-of-function,20516115, +BRCA1,N810Y,Likely Neutral,Likely Neutral,23867111, +BRCA1,M1663K,Likely Neutral,Likely Neutral,20516115, +BRCA1,V1378I,Likely Neutral,Likely Neutral,23867111, +BRCA1,K45T,Inconclusive,Inconclusive,"22034435, 16403807", +BRCA1,G1706E,Likely Oncogenic,Loss-of-function,"15172985, 23867111, 20516115, 17308087", +BRCA1,P1614S,Likely Neutral,Likely Neutral,17308087, +BRCA1,L1844R,Likely Neutral,Likely Neutral,20516115, +BRCA1,R1835P,Likely Oncogenic,Likely Loss-of-function,20516115, +BRCA1,M1783T,Inconclusive,Inconclusive,"15004537, 15172985, 20516115", +BRCA1,S988A,Likely Neutral,Likely Neutral,23867111, +BRCA1,W1837C,Likely Oncogenic,Likely Loss-of-function,20516115, +BRCA1,K56N,Inconclusive,Inconclusive,"22034435, 16403807", +BRCA1,S1715N,Likely Oncogenic,Loss-of-function,"15172985, 20516115, 11157798", +BRCA1,K65M,Inconclusive,Inconclusive,"22034435, 16403807", +BRCA1,R496C,Likely Neutral,Likely Neutral,"18036263, 18497862", +BRCA1,M1652K,Likely Oncogenic,Likely Loss-of-function,"15004537, 15172985, 10811118", +BRCA1,A1752G,Likely Neutral,Likely Neutral,23842040, +BRCA1,S1301R,Likely Neutral,Likely Neutral,23867111, +BRCA1,G1763V,Likely Oncogenic,Likely Loss-of-function,20516115, +BRCA1,S1613C,Likely Neutral,Likely Neutral,18992264, +BRCA1,S1841R,Likely Oncogenic,Likely Loss-of-function,20516115, +BRCA1,M1411T,Inconclusive,Inconclusive,"23867111, 19369211, 16793542, 15770685", +BRCA1,C39S,Inconclusive,Inconclusive,"22034435, 16403807", +BRCA1,C47G,Likely Oncogenic,Loss-of-function,"20103620, 22034435, 23161852, 16403807", +BRCA1,L82P,Inconclusive,Inconclusive,"22034435, 16403807", +BRCA1,T1773I,Likely Oncogenic,Likely Loss-of-function,20516115, +BRCA1,M18T,Oncogenic,Loss-of-function,"20103620, 23867111, 23161852, 21922593", +BRCA1,Q1785H,Likely Neutral,Likely Neutral,"20516115, 17308087", +BRCA1,F1704S,Likely Oncogenic,Likely Loss-of-function,"15172985, 11573086, 12496477", +BRCA1,V1665M,Likely Neutral,Likely Neutral,"15172985, 20516115, 11157798", +BRCA1,S72R,Inconclusive,Inconclusive,"22034435, 16403807", +BRCA1,F79S,Inconclusive,Inconclusive,"22034435, 16403807", +BRCA1,N1647K,Likely Neutral,Likely Neutral,20516115, +BRCA1,S59R,Inconclusive,Inconclusive,"22034435, 16403807", +BRCA1,D1344H,Inconclusive,Inconclusive,25416589, +BRCA1,F1734S,Likely Oncogenic,Likely Loss-of-function,"15172985, 20516115", +BRCA1,C360R,Likely Neutral,Likely Neutral,23867111, +BRCA1,S1651F,Likely Neutral,Neutral,"23867111, 20516115", +BRCA1,R170Q,Likely Neutral,Neutral,23161852, +BRCA1,V1736G,Likely Oncogenic,Likely Loss-of-function,20516115, +BRCA1,D1818G,Inconclusive,Inconclusive,20516115, +BRCA1,I15T,Inconclusive,Inconclusive,"22034435, 16403807", +BRCA1,L1705P,Likely Oncogenic,Likely Loss-of-function,"15172985, 10811118, 11573086", +BRCA1,S1841N,Likely Oncogenic,Likely Loss-of-function,"15172985, 9799248, 20516115", +BRCA1,F1734L,Likely Oncogenic,Likely Loss-of-function,"15172985, 12496477", +BRCA1,I124V,Inconclusive,Inconclusive,23161852, +BRCA1,D1739E,Likely Oncogenic,Likely Loss-of-function,"15004537, 15172985, 20516115", +BRCA1,Y1703H,Likely Oncogenic,Likely Loss-of-function,"15172985, 10811118, 11573086", +BRCA1,L1764P,Likely Oncogenic,Loss-of-function,"15172985, 23867111, 20516115, 17308087", +BRCA1,R1726G,Likely Neutral,Likely Neutral,20516115, +BRCA1,S1722F,Likely Oncogenic,Loss-of-function,"15172985, 9799248, 10196379, 20516115", +BRCA1,G1770V,Likely Oncogenic,Loss-of-function,"23867111, 23613828", +BRCA1,D1692H,Likely Oncogenic,Likely Loss-of-function,20516115, +BRCA1,H1746Q,Inconclusive,Inconclusive,23867111, +BRCA1,P798L,Likely Neutral,Likely Neutral,23867111, +BRCA1,W1718S,Likely Oncogenic,Likely Loss-of-function,"15172985, 20516115", +BRCA1,P1637L,Likely Neutral,Likely Neutral,9159158, +BRCA1,R1751Q,Likely Neutral,Likely Neutral,"9150149, 15172985, 20516115", +BRCA1,L246V,Likely Neutral,Likely Neutral,23867111, +BRCA1,K45Q,Likely Neutral,Likely Neutral,23867111, +BRCA1,L165P,Likely Neutral,Likely Neutral,23867111, +BRCA1,L1664P,Likely Neutral,Likely Neutral,"15172985, 20516115, 17308087", +BRCA1,V1534M,Likely Neutral,Likely Neutral,"23867111, 17308087", +BRCA1,M1628T,Likely Neutral,Likely Neutral,"23867111, 15350310, 15689452", +BRCA1,H1421Y,Likely Neutral,Likely Neutral,15689452, +BRCA1,I42V,Likely Neutral,Neutral,"20103620, 23161852", +BRCA1,C1787S,Likely Neutral,Likely Neutral,"15172985, 11573086, 20516115", +BRCA1,M18K,Inconclusive,Inconclusive,"22034435, 16403807", +BRCA1,T1685A,Likely Oncogenic,Likely Loss-of-function,"15172985, 20516115", +BRCA1,E1682K,Likely Neutral,Likely Neutral,20516115, +BRCA1,N1730S,Likely Neutral,Likely Neutral,"15172985, 20516115", +BRCA1,W1837G,Likely Oncogenic,Likely Loss-of-function,"15172985, 9799248, 20516115", +BRCA1,R1589H,Likely Neutral,Likely Neutral,23613828, +BRCA1,V1653M,Likely Oncogenic,Likely Loss-of-function,"15004537, 15172985, 20516115", +BRCA1,G1803A,Likely Oncogenic,Likely Loss-of-function,"15172985, 20516115", +BRCA1,I89N,Inconclusive,Inconclusive,"22034435, 16403807", +BRCA1,T37R,Likely Oncogenic,Loss-of-function,"20103620, 22034435, 23161852, 16403807", +BRCA1,H1805P,Likely Neutral,Likely Neutral,20516115, +BRCA1,V1714G,Likely Oncogenic,Likely Loss-of-function,20516115, +BRCA1,E1060A,Likely Neutral,Likely Neutral,23867111, +BRCA1,I1766S,Likely Oncogenic,Loss-of-function,"18680205, 20516115, 17308087", +BRCA1,E1346K,Likely Neutral,Likely Neutral,23867111, +BRCA1,S1486C,Likely Neutral,Likely Neutral,23867111, +BRCA1,K45N,Inconclusive,Inconclusive,"22034435, 16403807", +BRCA1,K1110del,Likely Neutral,Likely Neutral,23867111, +BRCA1,F1695L,Likely Neutral,Likely Neutral,"15172985, 17161371, 20516115", +BRCA1,S1715R,Likely Oncogenic,Loss-of-function,"15172985, 20516115, 11157798", +BRCA1,W1718L,Likely Oncogenic,Likely Loss-of-function,23613828, +BRCA1,S1497A,Likely Neutral,Likely Neutral,23867111, +BRCA1,V1833E,Likely Oncogenic,Likely Loss-of-function,"15172985, 10811118", +BRCA1,P1859R,Likely Neutral,Likely Neutral,"15172985, 20516115", +BRCA1,M1008I,Likely Neutral,Likely Neutral,23867111, +BRCA1,E1836K,Likely Oncogenic,Likely Loss-of-function,20516115, +BRCA1,E60L,Inconclusive,Inconclusive,"22034435, 16403807", +BRCA1,L668F,Likely Neutral,Likely Neutral,23867111, +BRCA1,V191D,Likely Neutral,Likely Neutral,23161852, +BRCA1,S1655F,Likely Oncogenic,Loss-of-function,"15004537, 23867111, 20516115, 17308087", +BRCA1,D1739V,Likely Oncogenic,Loss-of-function,"23867111, 20516115", +BRCA1,M1783I,Likely Neutral,Likely Neutral,20516115, +BRCA1,V271L,Likely Neutral,Neutral,23867111, +BRCA1,C61G,Likely Oncogenic,Loss-of-function,"14729053, 20103620, 23867111, 22034435, 15569676, 23161852, 16403807", +BRCA1,H1686Q,Likely Oncogenic,Loss-of-function,"15172985, 23867111, 12496477", +BRCA1,T1700A,Likely Oncogenic,Loss-of-function,"20516115, 17308087", +BRCA1,V1804D,Inconclusive,Inconclusive,"15004537, 15172985, 23867111, 15350310, 20516115, 17308087", +BRCA1,D1739Y,Likely Oncogenic,Likely Loss-of-function,"15172985, 20516115", +BRCA1,K1487R,Likely Oncogenic,Likely Loss-of-function,18992264, +BRCA1,P1749R,Oncogenic,Loss-of-function,"14729053, 15172985, 8751436, 15569676, 10635334, 20516115, 21922593, 9159158", +BRCA1,S1448G,Likely Neutral,Likely Neutral,23867111, +BRCA1,P1806A,Likely Neutral,Likely Neutral,"15004537, 15172985, 10811118, 20516115, 17308087", +BRCA1,R1699L,Likely Oncogenic,Likely Loss-of-function,"15172985, 11573086, 20516115", +BRCA1,A1708V,Likely Oncogenic,Likely Loss-of-function,20516115, +BRCA1,Y105C,Likely Neutral,Neutral,"23867111, 23161852", +BRCA1,A1823T,Likely Neutral,Likely Neutral,"15172985, 12142080, 20516115", +BRCA1,Q1756fs,Oncogenic,Loss-of-function,"14729053, 23867111, 27454287, 15569676, 9145676, 14576434", +BRCA1,M1775R,Oncogenic,Loss-of-function,"15004537, 14729053, 10811118, 12427738, 7545954, 8751436, 16101277, 11573086, 15689452, 15569676, 8942979, 10635334, 23161852, 15133502, 7939630, 15172985, 20516115, 21922593, 9159158", +BRCA1,R71G,Inconclusive,Inconclusive,"20103620, 11385711, 23161852", +BRCA1,L358R,Likely Neutral,Likely Neutral,23867111, +BRCA1,K50L,Inconclusive,Inconclusive,"22034435, 16403807", +BRCA1,R1758G,Inconclusive,Inconclusive,"15172985, 9544765", +BRCA1,Y1703S,Likely Oncogenic,Likely Loss-of-function,23613828, +BRCA1,I21V,Likely Neutral,Neutral,"20103620, 23161852", +BRCA1,I1807S,Likely Oncogenic,Likely Loss-of-function,"15172985, 12496477", +BRCA1,R866C,Likely Neutral,Likely Neutral,23867111, +BRCA1,Deletion,Likely Oncogenic,Likely Loss-of-function,"12483515, 18501021, 27452521, 12670888, 9354803", +BRCA1,F1761S,Likely Oncogenic,Loss-of-function,"15172985, 10811118, 20516115", +BRCA1,S1715C,Likely Oncogenic,Likely Loss-of-function,20516115, +BRCA1,P1856T,Inconclusive,Inconclusive,15172985, +BRCA1,D67Y,Likely Neutral,Neutral,"20103620, 23867111, 23161852", +BRCA1,T826K,Inconclusive,Inconclusive,"23867111, 10635334", +BRCA1,I31M,Likely Neutral,Neutral,"20103620, 23161852, 16403807", +BRCA1,M1652I,Likely Neutral,Likely Neutral,"18992264, 15172985, 23867111, 9326340, 12215251, 9523200, 20516115, 21922593, 9159158", +BRCA1,V11A,Inconclusive,Inconclusive,18493658, +BRCA1,C27A,Likely Oncogenic,Loss-of-function,"20103620, 23161852", +BRCA1,T1852S,Inconclusive,Inconclusive,15172985, +BRCA1,Y856H,Likely Neutral,Likely Neutral,23867111, +BRCA1,D1692N,Likely Neutral,Likely Neutral,"15172985, 10196379, 20516115, 11157798", +BRCA1,D1692Y,Likely Oncogenic,Likely Loss-of-function,"15172985, 20516115", +BRCA1,T47D,Likely Neutral,Likely Neutral,15569676, +BRCA1,D245V,Likely Neutral,Likely Neutral,23867111, +BRCA1,E1282V,Likely Neutral,Likely Neutral,23867111, +BRCA1,G1656D,Likely Oncogenic,Likely Loss-of-function,20516115, +BRCA1,V191I,Likely Neutral,Likely Neutral,23867111, +BRCA1,A1843T,Likely Oncogenic,Likely Loss-of-function,"15172985, 11573086, 12496477", +BRCA1,L147F,Likely Neutral,Likely Neutral,23867111, +BRCA1,D1546N,Inconclusive,Inconclusive,17308087, +BRCA1,T1691I,Likely Oncogenic,Likely Loss-of-function,"23867111, 20516115", +BRCA1,G1788V,Likely Oncogenic,Loss-of-function,"15004537, 15172985, 9796975, 15689452, 20516115", +BRCA1,C1697R,Likely Oncogenic,Loss-of-function,"15172985, 20516115, 11157798", +BRCA1,D1778G,Likely Neutral,Likely Neutral,"15172985, 20516115", +BRCA1,I26N,Inconclusive,Inconclusive,"22034435, 16403807", +BRCA1,C44F,Likely Oncogenic,Loss-of-function,"20103620, 22034435, 23161852, 16403807", +BRCA1,E1214K,Likely Neutral,Likely Neutral,23867111, +BRCA1,G57R,Inconclusive,Inconclusive,"22034435, 16403807", +BRCA1,M1775V,Likely Neutral,Likely Neutral,"15172985, 11573086, 8942979", +BRCA1,L1657P,Likely Oncogenic,Likely Loss-of-function,"15172985, 12496477", +BRCA1,N1236K,Likely Neutral,Likely Neutral,23867111, +BRCA1,A1752V,Likely Oncogenic,Likely Loss-of-function,20516115, +BRCA1,A1752P,Likely Oncogenic,Loss-of-function,"15172985, 15689452, 20516115", +BRCA1,V1808A,Likely Neutral,Likely Neutral,"15004537, 15172985, 20516115", +BRCA1,L1854P,Likely Oncogenic,Likely Loss-of-function,20516115, +BRCA1,W1718C,Likely Oncogenic,Loss-of-function,"15172985, 23867111, 9799248, 20516115", +BRCA1,C24Y,Likely Oncogenic,Likely Loss-of-function,"20103620, 22034435, 23161852, 16403807", +BRCA1,S1140G,Likely Neutral,Likely Neutral,23867111, +BRCA1,V1696L,Likely Oncogenic,Likely Loss-of-function,"15172985, 20516115", +BRCA1,V1688del,Likely Oncogenic,Likely Loss-of-function,23867111, +BRCA1,D695N,Likely Neutral,Likely Neutral,23867111, +BRCA1,W1782C,Likely Neutral,Likely Neutral,23867111, +BRCA1,G1743R,Likely Oncogenic,Likely Loss-of-function,"15172985, 12496477", +BRCA1,W1837R,Likely Oncogenic,Loss-of-function,"15172985, 23867111, 9799248, 8968102, 15689452, 20516115", +BRCA1,R1699Q,Likely Oncogenic,Loss-of-function,"15172985, 23867111, 11573086, 20516115, 11157798", +BRCA1,S1841A,Likely Oncogenic,Likely Loss-of-function,21922593, +BRCA1,Q1409L,Likely Neutral,Likely Neutral,23613828, +BRCA1,C44Y,Oncogenic,Loss-of-function,"22034435, 21922593, 16403807", +BRCA1,V1713A,Oncogenic,Loss-of-function,"20516115, 17308087, 9159158", +BRCA1,V1804A,Inconclusive,Inconclusive,15004537, +BRCA1,R841Q,Likely Neutral,Likely Neutral,23867111, +BRCA1,R170W,Likely Neutral,Likely Neutral,23867111, +BRCA1,T1720A,Likely Neutral,Likely Neutral,"15004537, 15172985, 23867111, 15689452, 20516115", +BRCA1,T1691K,Likely Oncogenic,Likely Loss-of-function,20516115, +BRCA1,R1589P,Likely Neutral,Likely Neutral,23867111, +BRCA1,G1788D,Likely Oncogenic,Likely Loss-of-function,"15172985, 20516115, 17308087", +BRCA1,P1771L,Likely Neutral,Likely Neutral,"15172985, 20516115", +BRCA1,L63F,Inconclusive,Inconclusive,"22034435, 16403807", +BRCA1,A1830T,Likely Neutral,Likely Neutral,20516115, +BRCA1,T77M,Inconclusive,Inconclusive,"22034435, 16403807", +BRCA1,L1267S,Likely Neutral,Likely Neutral,23867111, +BRCA1,Q1826H,Likely Neutral,Likely Neutral,"18992264, 20516115", +BRCA1,I90T,Inconclusive,Inconclusive,23161852, +BRCA1,L28P,Inconclusive,Inconclusive,"22034435, 16403807", +BRCA1,Y179C,Inconclusive,Inconclusive,"18680205, 23161852", +BRCA1,H1862L,Likely Neutral,Likely Neutral,23867111, +BRCA1,M1628V,Likely Oncogenic,Likely Loss-of-function,15689452, +BRCA1,D1778H,Inconclusive,Inconclusive,"15172985, 9809041", +BRCA1,Q12Y,Inconclusive,Inconclusive,"22034435, 16403807", +BRCA1,C39Y,Oncogenic,Loss-of-function,"20103620, 22034435, 23161852, 21922593, 16403807", +BRCA1,S308A,Inconclusive,Inconclusive,23867111, +BRCA1,D1778N,Likely Neutral,Likely Neutral,"15172985, 20516115", +BRCA1,H1686R,Likely Oncogenic,Likely Loss-of-function,23867111, +BRCA1,T1685I,Likely Oncogenic,Loss-of-function,"15172985, 15689452, 20516115", +BRCA1,R1443G,Likely Neutral,Likely Neutral,"23867111, 17308087", +BRCA1,N1819Y,Inconclusive,Inconclusive,15004537, +BRCA1,R1753T,Likely Oncogenic,Loss-of-function,"23867111, 20516115, 17308087", +BRCA1,S1473P,Likely Neutral,Likely Neutral,23613828, +BRCA1,D1778Y,Likely Neutral,Likely Neutral,20516115, +BRCA1,R1751P,Likely Oncogenic,Likely Loss-of-function,"15172985, 20516115", +BRCA1,V1809A,Likely Neutral,Likely Neutral,"15172985, 20516115", +BRCA1,A1789S,Likely Neutral,Likely Neutral,20516115, +BRCA1,C39R,Inconclusive,Inconclusive,"22034435, 16403807", +BRCA1,C24R,Likely Oncogenic,Loss-of-function,"20103620, 23161852", +BRCA1,H1746N,Likely Oncogenic,Likely Loss-of-function,"15172985, 20516115", +BRCA1,P1812R,Likely Neutral,Likely Neutral,23867111, +BRCA1,P1776S,Inconclusive,Inconclusive,"15172985, 10196379", +BRCA1,E1682V,Likely Neutral,Likely Neutral,20516115, +BRCA1,H41R,Likely Oncogenic,Loss-of-function,"20103620, 22034435, 23161852, 16403807", +BRCA1,L1407P,Likely Oncogenic,Likely Loss-of-function,"23867111, 19369211, 15689452, 16793542, 15770685", +BRCA1,S153R,Likely Neutral,Neutral,23161852, +BRCA1,D1739G,Likely Oncogenic,Loss-of-function,"15004537, 15172985, 23867111, 20516115", +BRCA1,K1702E,Likely Oncogenic,Likely Loss-of-function,"15172985, 10811118", +BRCA1,M1783L,Likely Neutral,Likely Neutral,20516115, +BRCA1,K38N,Inconclusive,Inconclusive,"22034435, 16403807", +BRCA1,E23fs,Oncogenic,Loss-of-function,"14729053, 23867111, 27454287, 27454289, 15569676, 9145676, 14576434", +BRCA1,S1613G,Likely Neutral,Likely Neutral,9159158, +BRCA1,S1164I,Likely Oncogenic,Likely Loss-of-function,18680205, +BRCA1,Q1811R,Likely Oncogenic,Likely Loss-of-function,"15172985, 20516115", +BRCA1,P1856S,Likely Neutral,Likely Neutral,20516115, +BRCA1,D96N,Inconclusive,Inconclusive,"22034435, 16403807", +BRCA1,M1652T,Inconclusive,Inconclusive,"15004537, 15172985, 9585608, 20516115", +BRCA1,D1851E,Likely Neutral,Likely Neutral,20516115, +BRCA1,S4P,Inconclusive,Inconclusive,"22034435, 16403807", +BRCA1,E143K,Likely Neutral,Likely Neutral,23161852, +BRCA1,L52F,Likely Neutral,Neutral,"20103620, 22034435, 23161852, 16403807", +BRCA1,S186Y,Likely Neutral,Neutral,"23867111, 23161852", +BRCA1,Y1853C,Likely Oncogenic,Loss-of-function,"23842040, 20516115", +BRCA1,P1812A,Likely Oncogenic,Likely Loss-of-function,"15172985, 17020472", +BRCA1,V1833M,Likely Oncogenic,Likely Loss-of-function,"15004537, 18992264, 15172985, 12142080, 20516115", +BRCA1,G1706A,Likely Neutral,Neutral,"15172985, 23867111, 15689452, 15923272, 20516115", +BRCA1,T1773S,Likely Neutral,Likely Neutral,"15172985, 20516115", +BRCA1,E1735K,Inconclusive,Inconclusive,"15172985, 23867111, 9809041", +BRAF,T599_V600insETT,Likely Oncogenic,Likely Gain-of-function,16501605, +BRAF,R462E,Likely Oncogenic,Likely Gain-of-function,25155755, +BRAF,V600D,Oncogenic,Gain-of-function,"23317446, 20551065, 16273091, 12068308, 15035987", +BRAF,SND1-BRAF Fusion,Oncogenic,Gain-of-function,"25266736, 25985019, 22745804, 24345920", +BRAF,p61BRAF,Oncogenic,Gain-of-function,22113612, +BRAF,Non-V600 BRAF Mutations,null,null,, +BRAF,V600K,Oncogenic,Gain-of-function,"16273091, 22663011, 12068308, 25265492, 24508103, 25287827, 25399551, 15035987","Planchard et al. Abstract# 8009, ASCO 2013 http://meetinglibrary.asco.org/content/112427-132" +BRAF,CUL1-BRAF Fusion,Likely Oncogenic,Likely Gain-of-function,"25985019, 22745804, 15630448, 26324360", +BRAF,R671Q,Likely Oncogenic,Likely Gain-of-function,28174173, +BRAF,Fusions,Likely Oncogenic,Likely Gain-of-function,"18974108, 26314551, 25985019, 23890088, 22745804, 15630448, 26324360, 21424530, 24345920", +BRAF,G469L,Likely Oncogenic,Likely Gain-of-function,"24920063, 24035431", +BRAF,T488_P492del,Likely Oncogenic,Likely Gain-of-function,26732095, +BRAF,L597R,Likely Oncogenic,Likely Gain-of-function,"22798288, 26643848", +BRAF,V487_P492delinsA,Likely Oncogenic,Likely Gain-of-function,26732095, +BRAF,V459L,Inconclusive,Inconclusive,12460918, +BRAF,F595L,Likely Oncogenic,Gain-of-function,"15150094, 15035987", +BRAF,V600delinsYM,Oncogenic,Gain-of-function,22752848, +BRAF,L485_P490delinsY,Likely Oncogenic,Likely Gain-of-function,26732095, +BRAF,W531C,Likely Neutral,Likely Neutral,19206169, +BRAF,A728V,Likely Oncogenic,Gain-of-function,15035987, +BRAF,G478C,Likely Neutral,Loss-of-function,22926515, +BRAF,G466V,Likely Oncogenic,Gain-of-function,"22649091, 24202393, 16364920, 15035987, 16439621", +BRAF,L505H,Oncogenic,Gain-of-function,"25515853, 24112705, 24283590", +BRAF,A246P,Likely Oncogenic,Gain-of-function,16474404, +BRAF,L485_P490delinsF,Likely Oncogenic,Likely Gain-of-function,26732095, +BRAF,V600D_K601insFGLAT,Oncogenic,Gain-of-function,17297294, +BRAF,R462I,Likely Neutral,Neutral,"15150094, 15035987", +BRAF,E501K,Inconclusive,Inconclusive,"17603482, 16474404", +BRAF,G464R,Likely Oncogenic,Gain-of-function,15046639, +BRAF,Amplification,Oncogenic,Gain-of-function,"15467732, 24055054, 25618114, 22395615, 21098728", +BRAF,I326V,Likely Neutral,Likely Neutral,17603482, +BRAF,V600E,Oncogenic,Gain-of-function,"20179705, 16273091, 23153539, 12068308, 15035987", +BRAF,S151A,Likely Oncogenic,Likely Gain-of-function,21478863, +BRAF,AGK-BRAF Fusion,Oncogenic,Gain-of-function,"26314551, 23890088, 24135138", +BRAF,I463S,Likely Neutral,Likely Neutral,"15150094, 15035987", +BRAF,V600G,Likely Oncogenic,Gain-of-function,"20735442, 16273091, 12068308, 26287849, 15035987", +BRAF,L597S,Likely Oncogenic,Likely Gain-of-function,"22798288, 26643848", +BRAF,T529N,Likely Neutral,Likely Neutral,"15573099, 20538618", +BRAF,R509H,Likely Neutral,Loss-of-function,20179705, +BRAF,A598V,Likely Oncogenic,Gain-of-function,19200582, +BRAF,G466A,Likely Oncogenic,Gain-of-function,"17724477, 15035987", +BRAF,F468C,Oncogenic,Gain-of-function,15150094, +BRAF,K601E,Likely Oncogenic,Gain-of-function,"22798288, 24583796, 24933606, 26643848, 23248257, 15035987", +BRAF,K499E,Likely Oncogenic,Gain-of-function,"16474404, 16439621", +BRAF,L485_P490del,Oncogenic,Gain-of-function,26732095, +BRAF,G469del,Likely Oncogenic,Likely Gain-of-function,23833300, +BRAF,G596V,Likely Oncogenic,Likely Gain-of-function,"19376813, 16439621", +BRAF,D594Y,Likely Oncogenic,Likely Gain-of-function,"23833300, 20141835, 16439621", +BRAF,MKRN1-BRAF Fusion,Likely Oncogenic,Likely Gain-of-function,"18974108, 26314551, 15630448, 23817572", +BRAF,R506_K507insVLR,Likely Oncogenic,Gain-of-function,23817572, +BRAF,T599insTT,Oncogenic,Gain-of-function,21190184, +BRAF,AKAP9-BRAF Fusion,Oncogenic,Gain-of-function,15630448, +BRAF,K601Q,Likely Oncogenic,Gain-of-function,19206169, +BRAF,L597V,Oncogenic,Gain-of-function,"26343582, 12068308, 26643848, 15035987", +BRAF,L597Q,Likely Oncogenic,Gain-of-function,"26343582, 22798288, 26643848", +BRAF,G466R,Likely Oncogenic,Likely Gain-of-function,"16364920, 15046639, 15035987", +BRAF,KIAA1549-BRAF Fusion,Oncogenic,Gain-of-function,"18974108, 23533272, 24345920", +BRAF,V600R,Oncogenic,Gain-of-function,"16273091, 12068308, 23473613, 15035987, 23490649", +BRAF,E501G,Likely Neutral,Likely Neutral,"16474404, 16439621", +BRAF,D594N,Likely Oncogenic,Gain-of-function,22798288,"Noeparast et al. Abstract# 11091, ASCO 2015 http://meeting.ascopubs.org/cgi/content/abstract/33/15_suppl/11091" +BRAF,G596R,Likely Oncogenic,Gain-of-function,"14678966, 16364920, 15035987", +BRAF,D594A,Likely Oncogenic,Gain-of-function,"14678966, 20141835, 15035987", +BRAF,G469A,Oncogenic,Gain-of-function,"23833300, 12068308, 22510884, 15035987, 22773810, 16439621", +BRAF,A598T,Likely Neutral,Loss-of-function,"26619011, 22926515", +BRAF,K483M,Likely Oncogenic,Likely Gain-of-function,"19376813, 23533272, 15035987, 27025703", +BRAF,N581Y,Likely Oncogenic,Likely Gain-of-function,"19474002, 26084293, 19276360, 15035987", +BRAF,G469R,Likely Oncogenic,Gain-of-function,"26150740, 24920063, 16096377, 26343582, 26619011", +BRAF,PAPSS1-BRAF Fusion,Likely Oncogenic,Gain-of-function,"15630448, 24345920", +BRAF,S467A,Likely Oncogenic,Gain-of-function,"19376813, 16439621", +BRAF,TRIM24-BRAF Fusion,Likely Oncogenic,Gain-of-function,"15630448, 24345920", +BRAF,V471F,Oncogenic,Gain-of-function,25348715, +BRAF,V600M,Oncogenic,Gain-of-function,"23463675, 16273091, 12068308, 15035987, 25382067", +BRAF,G469V,Likely Oncogenic,Likely Gain-of-function,"25870796, 23401075", +BRAF,G469E,Likely Oncogenic,Likely Gain-of-function,"15150094, 22510884, 15035987, 16439621", +BRAF,K483E,Likely Oncogenic,Likely Gain-of-function,"27799065, 23533272, 15035987", +BRAF,N486_P490del,Likely Oncogenic,Likely Gain-of-function,"26732095, 18060073", +BRAF,T599dup,Oncogenic,Gain-of-function,"23833300, 21190184, 19363522", +BRAF,D594V,Likely Oncogenic,Gain-of-function,"14678966, 19376813, 15035987, 16439621", +BRAF,D594G,Likely Oncogenic,Likely Gain-of-function,"23833300, 18794803, 20141835, 16439621", +BRAF,D594E,Likely Oncogenic,Gain-of-function,20978199,"Noeparast et al. Abstract# 11091, ASCO 2015 http://meeting.ascopubs.org/cgi/content/abstract/33/15_suppl/11091" +BRAF,T241P,Likely Oncogenic,Likely Gain-of-function,19206169, +BRAF,Q257R,Likely Oncogenic,Gain-of-function,"19376813, 16474404, 16439621", +BRAF,FAM131B-BRAF Fusion,Likely Oncogenic,Gain-of-function,"15630448, 21424530", +BRAF,E275K,Likely Oncogenic,Likely Gain-of-function,19206169, +BRAF,L485F,Likely Oncogenic,Gain-of-function,"16474404, 16439621", +BRAF,G596C,Likely Oncogenic,Gain-of-function,,"Noeparast et al. Abstract# 11091, ASCO 2015 http://meeting.ascopubs.org/cgi/content/abstract/33/15_suppl/11091" +BRAF,T599_V600insEAT,Likely Oncogenic,Likely Gain-of-function,16501605, +BRAF,E586K,Likely Oncogenic,Gain-of-function,15035987, +BRAF,K601N,Likely Oncogenic,Gain-of-function,"24270325, 26343582", +BRAF,N581D,Likely Oncogenic,Likely Gain-of-function,16474404, +BRAF,Y472C,Likely Oncogenic,Gain-of-function,22649091, +BRAF,G464E,Likely Neutral,Likely Neutral,"15150094, 20141835, 15035987", +BRAF,G464V,Oncogenic,Gain-of-function,"15150094, 12068308, 15035987", +BRAF,V600_K601delinsE,Oncogenic,Gain-of-function,"26045855, 23833300", +BRAF,T599R,Oncogenic,Gain-of-function,"25120313, 19206169", +BRAF,Q201H,Inconclusive,Inconclusive,18060073, +BRAF,T529M,Likely Neutral,Likely Neutral,"15573099, 20538618", +BRAF,N581S,Likely Oncogenic,Likely Gain-of-function,15035987, +BRAF,T599_V600insV,Oncogenic,Gain-of-function,16501605, +BRAF,L485_Q494del,Likely Oncogenic,Likely Gain-of-function,26732095, +BRAF,T529I,Likely Neutral,Likely Neutral,"15573099, 20538618", +BRAF,G466E,Likely Oncogenic,Gain-of-function,"16364920, 15035987, 24446311", +BRAF,D287H,Likely Oncogenic,Likely Gain-of-function,26343582, +BRAF,T599I,Likely Oncogenic,Gain-of-function,15035987, +BRAF,L584F,Inconclusive,Inconclusive,23658559, +BRAF,P490_Q494del,Likely Oncogenic,Likely Gain-of-function,26732095, +BRCA2,N1102Y,Inconclusive,Inconclusive,17924331, +BRCA2,N987I,Inconclusive,Inconclusive,18824701, +BRCA2,V3079I,Inconclusive,Inconclusive,17924331, +BRCA2,R2304C,Inconclusive,Inconclusive,18824701, +BRCA2,K1434I,Inconclusive,Inconclusive,18824701, +BRCA2,T2250A,Inconclusive,Inconclusive,17924331, +BRCA2,R1190W,Inconclusive,Inconclusive,17924331, +BRCA2,R2418G,Inconclusive,Inconclusive,18824701, +BRCA2,L2653P,Likely Oncogenic,Likely Loss-of-function,"17924331, 18451181", +BRCA2,D2723H,Likely Oncogenic,Likely Loss-of-function,"16489001, 18451181, 15290653", +BRCA2,K2950N,Likely Neutral,Likely Neutral,"17924331, 18375895", +BRCA2,S1670A,Inconclusive,Inconclusive,18375895, +BRCA2,I2285V,Likely Neutral,Likely Neutral,"17924331, 18824701", +BRCA2,L2865V,Likely Neutral,Likely Neutral,18451181, +BRCA2,H2074N,Inconclusive,Inconclusive,17924331, +BRCA2,M784V,Inconclusive,Inconclusive,18824701, +BRCA2,H1918Y,Inconclusive,Inconclusive,17924331, +BRCA2,K2472T,Inconclusive,Inconclusive,18375895, +BRCA2,A75P,Inconclusive,Inconclusive,17924331, +BRCA2,G2274V,Inconclusive,Inconclusive,16489001, +BRCA2,P375S,Inconclusive,Inconclusive,17924331, +BRCA2,A2643G,Likely Neutral,Likely Neutral,18451181, +BRCA2,S196N,Likely Oncogenic,Likely Loss-of-function,22962691, +BRCA2,G1771D,Inconclusive,Inconclusive,17924331, +BRCA2,G2748D,Likely Oncogenic,Likely Loss-of-function,"17924331, 18451181", +BRCA2,K1690N,Inconclusive,Inconclusive,17924331, +BRCA2,L209F,Likely Neutral,Likely Neutral,22962691, +BRCA2,A2770T,Inconclusive,Inconclusive,16489001, +BRCA2,R2659T,Likely Oncogenic,Likely Loss-of-function,18451181, +BRCA2,A2717S,Inconclusive,Inconclusive,18375895, +BRCA2,R174C,Likely Oncogenic,Likely Loss-of-function,22962691, +BRCA2,S2670L,Likely Neutral,Likely Neutral,16489001, +BRCA2,G1194D,Inconclusive,Inconclusive,17924331, +BRCA2,T2515I,Inconclusive,Inconclusive,18375895, +BRCA2,D191G,Likely Oncogenic,Likely Loss-of-function,22962691, +BRCA2,R2973C,Likely Neutral,Likely Neutral,"17924331, 18451181, 18824701", +BRCA2,V1306I,Inconclusive,Inconclusive,17924331, +BRCA2,R2842C,Likely Oncogenic,Likely Loss-of-function,23108138, +BRCA2,D806H,Inconclusive,Inconclusive,17924331, +BRCA2,C1265S,Inconclusive,Inconclusive,16489001, +BRCA2,V894I,Inconclusive,Inconclusive,17924331, +BRCA2,T2722R,Inconclusive,Inconclusive,17924331, +BRCA2,T1354M,Inconclusive,Inconclusive,17924331, +BRCA2,A2351G,Inconclusive,Inconclusive,18824701, +BRCA2,P1819S,Likely Neutral,Likely Neutral,"17924331, 18824701", +BRCA2,R2318Q,Inconclusive,Inconclusive,16489001, +BRCA2,M2676T,Inconclusive,Inconclusive,18824701, +BRCA2,S384F,Likely Neutral,Likely Neutral,"16489001, 18824701", +BRCA2,Q2858R,Inconclusive,Inconclusive,18375895, +BRCA2,D1280V,Inconclusive,Inconclusive,17924331, +BRCA2,R2502C,Inconclusive,Inconclusive,17924331, +BRCA2,Q2384K,Inconclusive,Inconclusive,17924331, +BRCA2,S326R,Inconclusive,Inconclusive,18824701, +BRCA2,G173C,Likely Oncogenic,Likely Loss-of-function,22962691, +BRCA2,N2436I,Inconclusive,Inconclusive,17924331, +BRCA2,D2312V,Inconclusive,Inconclusive,17924331, +BRCA2,T630I,Inconclusive,Inconclusive,17924331, +BRCA2,R2336P,Likely Oncogenic,Likely Loss-of-function,"22505045, 9150172", +BRCA2,S1733F,Inconclusive,Inconclusive,17924331, +BRCA2,V2908G,Likely Neutral,Likely Neutral,"17924331, 18451181", +BRCA2,L2106P,Inconclusive,Inconclusive,18824701, +BRCA2,D2723G,Likely Oncogenic,Likely Loss-of-function,"17924331, 18451181", +BRCA2,Y3092C,Inconclusive,Inconclusive,17924331, +BRCA2,R2520Q,Likely Neutral,Likely Neutral,18451181, +BRCA2,W2626C,Inconclusive,Inconclusive,17924331, +BRCA2,N588D,Inconclusive,Inconclusive,18824701, +BRCA2,N56T,Inconclusive,Inconclusive,17924331, +BRCA2,E2663V,Likely Oncogenic,Likely Loss-of-function,"17924331, 16489001, 18451181", +BRCA2,R2602T,Likely Oncogenic,Likely Loss-of-function,"18424508, 22505045", +BRCA2,K2729N,Likely Neutral,Likely Neutral,"17924331, 18451181", +BRCA2,A1170V,Inconclusive,Inconclusive,18824701, +BRCA2,S1424C,Inconclusive,Inconclusive,18824701, +BRCA2,Y42C,Likely Neutral,Likely Neutral,"16489001, 18451181, 18824701, 15290653", +BRCA2,N2048I,Inconclusive,Inconclusive,17924331, +BRCA2,V2969M,Inconclusive,Inconclusive,17924331, +BRCA2,L2396F,Inconclusive,Inconclusive,17924331, +BRCA2,R2842H,Inconclusive,Inconclusive,17924331, +BRCA2,R2108H,Inconclusive,Inconclusive,17924331, +BRCA2,I1929V,Inconclusive,Inconclusive,17924331, +BRCA2,R2888C,Inconclusive,Inconclusive,17924331, +BRCA2,R18H,Inconclusive,Inconclusive,18375895, +BRCA2,R2784W,Likely Oncogenic,Likely Loss-of-function,18451181, +BRCA2,S869L,Inconclusive,Inconclusive,16489001, +BRCA2,S142I,Likely Oncogenic,Likely Loss-of-function,21638052, +BRCA2,E2856A,Likely Neutral,Likely Neutral,"16489001, 18824701", +BRCA2,D3170G,Inconclusive,Inconclusive,17924331, +BRCA2,N319T,Likely Neutral,Likely Neutral,18451181, +BRCA2,K513R,Likely Neutral,Likely Neutral,"17924331, 18375895", +BRCA2,E462G,Likely Neutral,Likely Neutral,"17924331, 18451181", +BRCA2,K607T,Inconclusive,Inconclusive,18375895, +BRCA2,D1420Y,Inconclusive,Inconclusive,18824701, +BRCA2,N1228D,Inconclusive,Inconclusive,17924331, +BRCA2,N2113S,Inconclusive,Inconclusive,17924331, +BRCA2,N1878K,Inconclusive,Inconclusive,18824701, +BRCA2,P655R,Inconclusive,Inconclusive,"18824701, 15290653", +BRCA2,D2723A,Likely Oncogenic,Likely Loss-of-function,18451181, +BRCA2,C554W,Inconclusive,Inconclusive,17924331, +BRCA2,R3052W,Likely Oncogenic,Likely Loss-of-function,18451181, +BRCA2,R2502H,Inconclusive,Inconclusive,18824701, +BRCA2,R2659K,Likely Oncogenic,Loss-of-function,"17924331, 18451181, 12624152", +BRCA2,D2665G,Likely Neutral,Likely Neutral,"17924331, 16489001", +BRCA2,Deletion,Oncogenic,Loss-of-function,"12483515, 18501021, 27452521, 11239455, 22193408, 16199546", +BRCA2,N517S,Inconclusive,Inconclusive,18824701, +BRCA2,D935N,Inconclusive,Inconclusive,18375895, +BRCA2,N372H,Likely Neutral,Likely Neutral,18451181, +BRCA2,S2483N,Inconclusive,Inconclusive,18824701, +BRCA2,S206C,Likely Oncogenic,Likely Loss-of-function,22962691, +BRCA2,S1172L,Likely Neutral,Likely Neutral,"17924331, 18375895, 18824701", +BRCA2,E3002K,Likely Oncogenic,Likely Loss-of-function,"21947752, 23108138, 20694749", +BRCA2,Y3098H,Inconclusive,Inconclusive,17924331, +BRCA2,L929S,Inconclusive,Inconclusive,18824701, +BRCA2,G602R,Inconclusive,Inconclusive,17924331, +BRCA2,L2647P,Likely Oncogenic,Likely Loss-of-function,18451181, +BRCA2,T582P,Inconclusive,Inconclusive,17924331, +BRCA2,F1524V,Inconclusive,Inconclusive,17924331, +BRCA2,T3349A,Inconclusive,Inconclusive,17924331, +BRCA2,N2829R,Likely Oncogenic,Likely Loss-of-function,22505045, +BRCA2,H1966Y,Inconclusive,Inconclusive,18824701, +BRCA2,V211I,Likely Oncogenic,Likely Loss-of-function,"19179552, 23451180, 22962691", +BRCA2,T2681R,Inconclusive,Inconclusive,18824701, +BRCA2,D3095E,Likely Oncogenic,Likely Loss-of-function,"17924331, 18451181", +BRCA2,R3052Q,Inconclusive,Inconclusive,17924331, +BRCA2,R2336H,Likely Oncogenic,Loss-of-function,"17924331, 18451181, 18489799", +BRCA2,T3211K,Inconclusive,Inconclusive,18824701, +BRCA2,L2721H,Inconclusive,Inconclusive,18824701, +BRCA2,I1349T,Inconclusive,Inconclusive,17924331, +BRCA2,G1529R,Inconclusive,Inconclusive,17924331, +BRCA2,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,"20878484, 24312913, 11239455, 22193408, 10570174", +BRCA2,Q1396R,Inconclusive,Inconclusive,17924331, +BRCA2,V1643A,Inconclusive,Inconclusive,18824701, +BRCA2,I2627F,Likely Oncogenic,Likely Loss-of-function,"17924331, 18451181", +BRCA2,I2675V,Likely Oncogenic,Likely Loss-of-function,18424508, +BRCA2,L1019V,Inconclusive,Inconclusive,17924331, +BRCA2,P168T,Inconclusive,Inconclusive,17924331, +BRCA2,D1352Y,Inconclusive,Inconclusive,18824701, +BRCA2,C3198R,Inconclusive,Inconclusive,17924331, +BRCA2,K2411T,Inconclusive,Inconclusive,17924331, +BRCA2,C1365Y,Inconclusive,Inconclusive,17924331, +BRCA2,L1904V,Inconclusive,Inconclusive,17924331, +NF2,Q324L,Likely Neutral,Likely Neutral,11448944, +NF2,A211D,Likely Oncogenic,Likely Loss-of-function,"21383154, 20178741", +NF2,E106G,Likely Oncogenic,Likely Loss-of-function,11448944, +NF2,T352M,Likely Neutral,Likely Neutral,"10712203, 11448944", +NF2,Deletion,Likely Oncogenic,Likely Loss-of-function,"24726726, 15645494, 19451229, 22825583, 9643284", +NF2,L46R,Likely Oncogenic,Likely Loss-of-function,"21383154, 20178741", +NF2,K79E,Likely Oncogenic,Likely Loss-of-function,"10712203, 11448944", +NF2,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,"19545378, 8755919, 22825583, 9643284", +NF2,L64P,Likely Oncogenic,Likely Loss-of-function,"20178741, 11448944", +NF2,L535P,Likely Oncogenic,Likely Loss-of-function,"21383154, 20178741, 10712203, 11448944", +NF2,K413E,Inconclusive,Inconclusive,"21383154, 11448944", +NF2,Q538P,Likely Oncogenic,Likely Loss-of-function,11448944, +PAX8,PAX8-PPAR? Fusion,Oncogenic,Gain-of-function,"17131411, 10958784", +NFE2L2,W24C,Likely Oncogenic,Gain-of-function,"24142871, 18757741, 1875774", +NFE2L2,W24S,Likely Oncogenic,Gain-of-function,"24142871, 18757741, 1875774", +NFE2L2,E82V,Likely Oncogenic,Likely Gain-of-function,12167159, +NFE2L2,D29Y,Likely Oncogenic,Gain-of-function,"24142871, 18757741, 1875774", +NFE2L2,E79Q,Likely Oncogenic,Gain-of-function,"24142871, 18757741, 1875774", +NFE2L2,G81S,Likely Oncogenic,Gain-of-function,"24142871, 18757741, 1875774", +NFE2L2,V32G,Likely Oncogenic,Gain-of-function,"24142871, 18757741, 1875774", +NFE2L2,E82G,Likely Oncogenic,Gain-of-function,23365135, +NFE2L2,T80A,Likely Oncogenic,Gain-of-function,"24142871, 18757741, 1875774", +NFE2L2,T80K,Oncogenic,Gain-of-function,"24130096, 27147599, 18757741", +NFE2L2,L30F,Likely Oncogenic,Gain-of-function,"24142871, 18757741, 1875774", +NFE2L2,D29N,Likely Oncogenic,Gain-of-function,"24142871, 18757741, 1875774", +NFE2L2,G81R,Likely Oncogenic,Gain-of-function,"24142871, 18757741, 1875774", +NFE2L2,E79K,Likely Oncogenic,Gain-of-function,"24142871, 18757741, 1875774", +NFE2L2,G31A,Oncogenic,Gain-of-function,27147599, +NFE2L2,G81D,Likely Oncogenic,Gain-of-function,"24142871, 18757741, 1875774", +NFE2L2,G31R,Oncogenic,Gain-of-function,27147599, +NFE2L2,G31V,Oncogenic,Gain-of-function,27147599, +NFE2L2,E82D,Likely Oncogenic,Likely Gain-of-function,"24130096, 18757741", +NFE2L2,T80R,Likely Oncogenic,Gain-of-function,"24142871, 18757741, 1875774", +NFE2L2,D29H,Likely Oncogenic,Gain-of-function,"24142871, 18757741, 1875774", +NFE2L2,D77H,Likely Oncogenic,Likely Gain-of-function,"16888629, 26619011", +NFE2L2,I28T,Likely Oncogenic,Gain-of-function,"24142871, 18757741, 1875774", +NFE2L2,W24R,Likely Oncogenic,Gain-of-function,"24142871, 18757741, 1875774", +GLI1,R380A,Likely Oncogenic,Likely Loss-of-function,25476449, +GLI1,Amplification,Oncogenic,Gain-of-function,"3563490, 1825351", +FUBP1,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,"22072542, 22588899, 21817013, 24117486", +BTK,Y551F,Likely Neutral,Loss-of-function,"20052711, 9188445, 20826165", +BTK,C481S,Likely Oncogenic,Gain-of-function,"25189416, 24869598", +BTK,R544S,Likely Oncogenic,Likely Gain-of-function,"20052711, 20826165", +NFKBIA,M37K,Likely Neutral,Likely Gain-of-function,23708964, +NFKBIA,S36Y,Likely Neutral,Likely Gain-of-function,23864385, +NFKBIA,S32I,Likely Neutral,Gain-of-function,14523047, +NFKBIA,E14*,Likely Neutral,Gain-of-function,18412279, +GNA11,R183C,Oncogenic,Gain-of-function,21083380, +GNA11,Q209L,Oncogenic,Gain-of-function,21083380, +KDR,C482R,Likely Oncogenic,Likely Gain-of-function,"18931684, 25411163, 21712447", +KDR,Amplification,Oncogenic,Gain-of-function,"11114740, 26578684", +KDR,D717V,Oncogenic,Gain-of-function,19723655, +KDR,A1065T,Likely Oncogenic,Gain-of-function,19723655, +KDR,T771R,Inconclusive,Inconclusive,"26422291, 19723655", +KDR,Q472H,Likely Oncogenic,Likely Gain-of-function,"24793135, 24599305, 21712447","Mockus et al. Abstract# 73, AACR 2015 http://cancerres.aacrjournals.org/content/75/15_Supplement/73" +KDR,R961W,Inconclusive,Inconclusive,27004155, +BCL10,Deletion,Likely Oncogenic,Likely Loss-of-function,"10319863, 9989495, 10845924", +BCL10,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,"10319863, 9989495", +GNAQ,Q209L,Oncogenic,Gain-of-function,"19078957, 1328859, 21083380", +GNAQ,R183Q,Likely Oncogenic,Likely Gain-of-function,22236444, +GNAS,R201H,Oncogenic,Gain-of-function,"26257060, 24498386", +GNAS,R201C,Oncogenic,Gain-of-function,"25288233, 20531296", +GNAS,Q227R,Likely Oncogenic,Likely Gain-of-function,2549426, +GNAS,Q227L,Likely Oncogenic,Likely Gain-of-function,2549426, +GNAS,R844H,Oncogenic,Gain-of-function,"15148396, 19423757", +MGA,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,23039309, +MGA,Deletion,Likely Oncogenic,Likely Loss-of-function,10601024, +KIT,V555_V559del,Likely Oncogenic,Gain-of-function,"18955458, 15930355", +KIT,V559D,Oncogenic,Gain-of-function,"15790786, 17372901, 18980976, 18955458, 16954519, 25605837, 15930355, 17699867, 9438854", +KIT,V560D,Oncogenic,Gain-of-function,"23775962, 16551858, 23840364, 25239608, 18955458, 16954519, 25605837, 9438854", +KIT,P551_E554del,Oncogenic,Gain-of-function,"25239608, 16954519", +KIT,I563_L576del,Likely Oncogenic,Likely Gain-of-function,15930355, +KIT,P838L,Likely Oncogenic,Likely Gain-of-function,21642685, +KIT,Y578C,Likely Oncogenic,Gain-of-function,23567324, +KIT,T417_D419delinsRG,Oncogenic,Gain-of-function,15790786, +KIT,N822I,Oncogenic,Gain-of-function,21689725, +KIT,D816V,Oncogenic,Gain-of-function,"15972446, 19193436, 7479840, 26002753, 16434489, 16397263, 15725473, 15790786, 17545544, 22301675, 16254134, 14645423, 16779792, 23659595, 23416972", +KIT,K550_W557del,Oncogenic,Gain-of-function,25239608, +KIT,P551_V555del,Oncogenic,Gain-of-function,9438854, +KIT,E554_K558del,Likely Oncogenic,Likely Gain-of-function,"18955458, 16954519, 15930355", +KIT,N822K,Oncogenic,Gain-of-function,"15790786, 23840364, 21482694, 24490049, 21642685, 25695690, 22614970, 16954519, 26316776, 17699867", +KIT,W557_K558del,Oncogenic,Gain-of-function,"14645423, 25239608, 16954519, 15930355, 17699867", +KIT,Y418_D419del,Likely Oncogenic,Gain-of-function,"22825855, 19603346, 16143141", +KIT,D572A,Likely Oncogenic,Gain-of-function,19865100, +KIT,N505I,Oncogenic,Gain-of-function,24317392, +KIT,Y568_L576delinsVN,Likely Oncogenic,Likely Gain-of-function,18955458, +KIT,550_592del,Oncogenic,Gain-of-function,"18235121, 17372901, 25079768, 12181401, 15365079, 16098458, 15451219", +KIT,N564_Y578del,Likely Oncogenic,Likely Gain-of-function,16952044, +KIT,A504_Y505ins,Likely Oncogenic,Likely Gain-of-function,16551858, +KIT,A502_Y503dup,Oncogenic,Gain-of-function,"22350270, 25239608, 18955458, 16954519, 21527588, 17699867", +KIT,P551_M552del,Likely Oncogenic,Likely Gain-of-function,18955458, +KIT,L576P,Oncogenic,Gain-of-function,"22357254, 17372901, 26264378, 18980976, 25605837, 15930355, 19671763, 22068222, 23775962, 21642685, 25695690, 18955458, 16954519", +KIT,K550_K558del,Oncogenic,Gain-of-function,"16954519, 9438854", +KIT,Q556_K558del,Likely Oncogenic,Likely Gain-of-function,"19369884, 17372901, 25079768", +KIT,V654A,Likely Oncogenic,Gain-of-function,"18623623, 23840364, 21642685, 18955458, 16954519, 16751810", +KIT,T574_R588delinsL,Likely Oncogenic,Likely Gain-of-function,18955458, +KIT,R634W,Oncogenic,Gain-of-function,15790786, +KIT,D419del,Likely Oncogenic,Gain-of-function,"16143141, 23599150", +KIT,V852I,Likely Oncogenic,Likely Gain-of-function,21642685, +KIT,C809G,Likely Oncogenic,Likely Gain-of-function,"17139461, 18955458, 16954519", +KIT,V559I,Likely Oncogenic,Gain-of-function,17259998, +KIT,N463S,Likely Oncogenic,Likely Gain-of-function,21642685, +KIT,Y553_Q556del,Likely Oncogenic,Gain-of-function,15690055, +KIT,P577_W582delinsPYD,Likely Oncogenic,Likely Gain-of-function,23775962, +KIT,V530I,Oncogenic,Gain-of-function,"20339585, 16081693", +KIT,N655K,Likely Oncogenic,Likely Gain-of-function,17489795, +KIT,D816N,Likely Oncogenic,Gain-of-function,11369651, +KIT,P573_D579del,Likely Oncogenic,Gain-of-function,"12569358, 9438854", +KIT,V559del,Likely Oncogenic,Gain-of-function,"23993026, 15236194, 10485475, 16751810", +KIT,K642E,Likely Oncogenic,Gain-of-function,"24855380, 23940219, 11526490, 25695690, 25304235, 25239608, 14645423, 16954519", +KIT,W557R,Likely Oncogenic,Gain-of-function,"14977822, 10224103, 19018266, 22357254, 21953054, 25079768, 21325067, 18980976, 21906875, 21642685, 20859122, 12888812", +KIT,Y553N,Likely Oncogenic,Likely Gain-of-function,"21969494, 22357254", +KIT,M552_W557del,Likely Oncogenic,Likely Gain-of-function,"16551858, 16954519", +KIT,M552_K558del,Likely Oncogenic,Likely Gain-of-function,25239608, +KIT,R796G,Likely Neutral,Loss-of-function,20824047, +KIT,D816E,Likely Oncogenic,Likely Gain-of-function,"16551858, 25239608, 16397263", +KIT,T417_D419delinsI,Oncogenic,Gain-of-function,15790786, +KIT,N822H,Likely Oncogenic,Gain-of-function,"14645423, 18955458, 16954519", +KIT,T574insTQLPYD,Likely Oncogenic,Likely Gain-of-function,15930355, +KIT,Exon 9 mutations,Oncogenic,Gain-of-function,"18235121, 12181401, 23076159, 17662946, 24061512, 18955458, 16098458, 15451219", +KIT,D820A,Likely Oncogenic,Likely Gain-of-function,"23840364, 25239608, 18955458, 16954519", +KIT,Exon 11 deletions,Oncogenic,Gain-of-function,"18235121, 17372901, 25079768, 12181401, 15365079, 16098458, 15451219", +KIT,A829P,Likely Oncogenic,Likely Gain-of-function,"18623623, 18980976, 21642685, 25239608, 18955458", +KIT,P551_W557delinsL,Likely Oncogenic,Likely Gain-of-function,25239608, +KIT,E839K,Likely Neutral,Neutral,15790786, +KIT,D816G,Oncogenic,Gain-of-function,25239608, +KIT,C443Y,Likely Oncogenic,Gain-of-function,19865100, +KIT,D52N,Likely Oncogenic,Likely Gain-of-function,9168438, +KIT,E554_V559del,Likely Oncogenic,Likely Gain-of-function,18980976, +KIT,V559C,Likely Oncogenic,Likely Gain-of-function,"15897563, 21642685, 25695690, 9438854", +KIT,V559_G565del,Likely Oncogenic,Likely Gain-of-function,16551858, +KIT,Y553_K558del,Likely Oncogenic,Likely Gain-of-function,16954519, +KIT,M541L,Likely Oncogenic,Likely Gain-of-function,"25015329, 21757432, 15790786, 20664593, 21498700, 18795925, 16307017", +KIT,K509I,Likely Oncogenic,Gain-of-function,19865100, +KIT,Y823D,Oncogenic,Gain-of-function,"20633291, 22069175, 16551858, 18623623, 22301675, 18980976, 22089421, 18955458, 16954519, 15930355", +KIT,L576del,Likely Oncogenic,Gain-of-function,"19802003, 12717247", +KIT,D816A,Likely Oncogenic,Likely Gain-of-function,"18955458, 16397263", +KIT,W557G,Likely Oncogenic,Likely Gain-of-function,"10224103, 25079768, 15342366", +KIT,I653T,Likely Oncogenic,Likely Gain-of-function,21642685, +KIT,N822Y,Likely Oncogenic,Likely Gain-of-function,"21689725, 18724244", +KIT,D816F,Oncogenic,Gain-of-function,16397263, +KIT,V559G,Oncogenic,Gain-of-function,"23348204, 12569358", +KIT,K550_V555delinsI,Oncogenic,Gain-of-function,9438854, +KIT,S709F,Likely Oncogenic,Likely Gain-of-function,16551858, +KIT,D816Y,Oncogenic,Gain-of-function,"15790786, 15167915, 16397263, 15725473", +KIT,K558_V559del,Likely Oncogenic,Likely Gain-of-function,"18955458, 16954519", +KIT,D579del,Likely Oncogenic,Likely Gain-of-function,"24419427, 18955458", +KIT,Exon 11 mutations,Oncogenic,Gain-of-function,"18235121, 17372901, 25079768, 12181401, 17046465, 19282169, 25641662, 16098458, 15451219, 23177515, 19536093", +KIT,D737N,Inconclusive,Inconclusive,26863566, +KIT,V555_L576del,Likely Oncogenic,Gain-of-function,23840364, +KIT,W557_V560del,Likely Oncogenic,Likely Gain-of-function,"23775962, 18955458", +KIT,K558_E562del,Likely Oncogenic,Likely Gain-of-function,25735500, +KIT,K558delinsNP,Oncogenic,Gain-of-function,"11526490, 25239608, 18955458, 16954519", +KIT,T670I,Oncogenic,Gain-of-function,"16551858, 17545544, 23840364, 16954519, 17699867", +KIT,Y570H,Likely Oncogenic,Likely Gain-of-function,21642685, +KIT,D820G,Likely Oncogenic,Likely Gain-of-function,"16551858, 18623623, 23840364, 18955458, 16954519, 21456006", +KIT,K558N,Likely Oncogenic,Likely Gain-of-function,18980976, +KIT,S501_A502dup,Likely Oncogenic,Gain-of-function,22324351, +KIT,H697Y,Oncogenic,Gain-of-function,19861435, +KIT,F522C,Likely Oncogenic,Gain-of-function,15070706, +KIT,E554_I571del,Likely Oncogenic,Likely Gain-of-function,16954519, +KIT,D820E,Likely Oncogenic,Likely Gain-of-function,"19461405, 25886408, 15685537", +KIT,Amplification,Likely Oncogenic,Likely Gain-of-function,"15650049, 18506689, 16166280, 21523721, 19779861, 15869870, 24868028, 17189383", +KIT,E490K,Likely Oncogenic,Likely Gain-of-function,22357254, +KIT,D60N,Likely Oncogenic,Gain-of-function,"24211109, 16226710", +KIT,V560del,Oncogenic,Gain-of-function,"22357254, 16551858, 19861435, 15201427, 25605837", +KIT,V569_L576del,Likely Oncogenic,Likely Gain-of-function,"16551858, 15930355", +KIT,V559_V560del,Oncogenic,Gain-of-function,"16551858, 15790786, 16954519", +KIT,D820Y,Likely Oncogenic,Likely Switch-of-function,"14977822, 16551858, 18623623, 23840364, 25239608, 22614970, 18955458, 15930355, 17699867", +KIT,D816H,Oncogenic,Gain-of-function,"18623623, 16956837, 18980976, 25304235, 25239608, 18955458, 16954519, 16397263", +KIT,V560G,Oncogenic,Gain-of-function,"15790786, 16434489, 14645423, 16954519, 16397263", +KIT,V559A,Likely Oncogenic,Likely Gain-of-function,"15897563, 19812602, 16908931, 9438854", +KIT,W557_V559delinsC,Likely Oncogenic,Likely Gain-of-function,18955458, +KIT,P577_D579del,Likely Oncogenic,Likely Gain-of-function,22357254, +KIT,V560E,Likely Oncogenic,Likely Gain-of-function,"21690468, 22350270, 25239608", +KIT,S476I,Likely Oncogenic,Gain-of-function,19865100, +KIT,D814V,Oncogenic,Gain-of-function,12569358, +FGF19,Amplification,Likely Oncogenic,Likely Gain-of-function,"24265351, 23550210, 21397858, 22309595, 28481359", +MED12,G44S,Oncogenic,Switch-of-function,24746821, +MED12,G44D,Oncogenic,Switch-of-function,24746821, +MED12,L1224F,Likely Oncogenic,Likely Gain-of-function,"12218053, 26619011, 17612495, 26383637", +MED12,Deletion,Likely Oncogenic,Likely Loss-of-function,23178117, +MED12,Exon 1 mutations,Oncogenic,Gain-of-function,24980722, +MED12,Exon 2 mutations,Oncogenic,Likely Gain-of-function,"23738515, 25038752, 23913526, 21868628", +NOTCH1,SEC16A1-NOTCH1 Fusion,Oncogenic,Gain-of-function,22101766, +NOTCH1,I1680N,Likely Oncogenic,Gain-of-function,"22056382, 24651013, 16618740, 25806268, 16738328", +NOTCH1,F1592S,Likely Oncogenic,Gain-of-function,"22056382, 24651013, 16618740, 25806268, 16738328", +NOTCH1,L2429V,Likely Oncogenic,Likely Gain-of-function,"24651013, 25564152, 21948802, 15472075", +NOTCH1,P2415del,Likely Oncogenic,Likely Gain-of-function,"24651013, 25564152, 21948802, 15472075", +NOTCH1,Truncating Mutations in the PEST Domain,Likely Oncogenic,Likely Gain-of-function,"22056382, 24651013, 16618740, 25564152, 21948802, 25806268, 15472075", +NOTCH1,P2417A,Likely Oncogenic,Likely Gain-of-function,"24651013, 25564152, 21948802, 15472075", +NOTCH1,P2412T,Likely Oncogenic,Likely Gain-of-function,"24651013, 25564152, 21948802, 15472075", +NOTCH1,G2420C,Likely Oncogenic,Likely Gain-of-function,"24651013, 25564152, 21948802, 15472075", +NOTCH1,L1678P,Likely Oncogenic,Gain-of-function,"22056382, 24651013, 16618740, 25806268, 16738328", +NOTCH1,V1578del,Likely Oncogenic,Likely Gain-of-function,"22056382, 24651013, 16618740, 25806268, 15472075, 16738328", +NOTCH1,L1593P,Likely Oncogenic,Gain-of-function,"22056382, 24651013, 16618740, 25806268, 16738328", +NOTCH1,I1718T,Likely Oncogenic,Gain-of-function,"22056382, 24651013, 16618740, 25806268, 16738328", +NOTCH1,R1594Q,Likely Oncogenic,Loss-of-function,"24651013, 22006338, 27228302", +NOTCH1,V1671I,Likely Oncogenic,Likely Gain-of-function,"24651013, 25376516, 15472075, 19340001", +NOTCH1,Deletion,Likely Oncogenic,Likely Gain-of-function,"22077063, 23734977, 20852131", +NOTCH1,Truncating Mutations Upstream of Transactivation Domain,Oncogenic,Likely Loss-of-function,"24651013, 22006338, 21798897, 21798893", +NOTCH1,Q2405Rfs*17,Likely Oncogenic,Likely Gain-of-function,"24651013, 25564152, 21948802, 15472075", +NOTCH1,G2430A,Likely Oncogenic,Gain-of-function,20823234, +NOTCH1,A2425T,Likely Oncogenic,Likely Gain-of-function,"24651013, 25564152, 21948802, 15472075", +NOTCH1,R1598P,Likely Oncogenic,Gain-of-function,"22056382, 24651013, 16618740, 25806268, 16738328", +NOTCH1,A1701P,Likely Oncogenic,Gain-of-function,"22056382, 24651013, 16618740, 25806268, 16738328", +NOTCH1,L1600P,Likely Oncogenic,Gain-of-function,"22056382, 24651013, 16618740, 25806268, 15472075, 16738328", +NOTCH1,Q2416*,Likely Oncogenic,Likely Gain-of-function,"24651013, 25564152, 21948802, 15472075", +NOTCH1,H2428Q,Likely Oncogenic,Likely Gain-of-function,"24651013, 25564152, 21948802, 15472075", +NOTCH1,L1574P,Oncogenic,Gain-of-function,"22056382, 24651013, 16618740, 25806268, 15472075, 16738328", +NOTCH1,MIR143-NOTCH1 Fusion,Likely Oncogenic,Likely Gain-of-function,23999936, +NOTCH1,I1616T,Likely Oncogenic,Gain-of-function,"22056382, 24651013, 16618740, 25806268, 16738328", +NOTCH1,I1616N,Likely Oncogenic,Gain-of-function,"22056382, 24651013, 16618740, 25806268, 16738328", +NOTCH1,V1676D,Likely Oncogenic,Gain-of-function,"22056382, 24651013, 16618740, 25806268, 16738328", +NOTCH1,V1605del,Likely Oncogenic,Likely Gain-of-function,"22056382, 24651013, 16618740, 25806268, 15472075, 16738328", +NOTCH1,Fusions,Likely Oncogenic,Likely Gain-of-function,"16688224, 22101766, 23033986", +NOTCH1,L1596H,Likely Oncogenic,Gain-of-function,"22056382, 24651013, 16618740, 25806268, 16738328", +NOTCH1,V1576E,Likely Oncogenic,Gain-of-function,"22056382, 24651013, 16618740, 25806268, 16738328", +NOTCH1,R1608S,Likely Neutral,Likely Neutral,"24651013, 16738328", +NOTCH2,2010_2471trunc,Likely Oncogenic,Likely Gain-of-function,21378989, +NOTCH2,1_2009trunc,Likely Oncogenic,Likely Loss-of-function,22006338, +RAC1,Q61R,Likely Oncogenic,Gain-of-function,26619011, +RAC1,C18Y,Likely Oncogenic,Gain-of-function,28115009, +RAC1,P29S,Oncogenic,Gain-of-function,"2546593, 22842228, 23284172, 25056119, 25465943", +RAC1,P29L,Oncogenic,Gain-of-function,23382236, +RAC1,C157Y,Likely Oncogenic,Gain-of-function,23382236, +RAC1,G12V,Oncogenic,Gain-of-function,"23382236, 23284172", +RAC1,Amplification,Likely Oncogenic,Gain-of-function,"24072884, 23474757", +DNMT3A,R882C,Likely Oncogenic,Likely Gain-of-function,"24656771, 27010239", +DNMT3A,Deletion,Likely Oncogenic,Likely Loss-of-function,"21067377, 27636998", +DNMT3A,R882H,Likely Oncogenic,Likely Gain-of-function,"22722925, 24167195, 24656771, 25416276, 27010239", +DNMT3A,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,"21067377, 25964253, 24614070", +DNMT3B,DNMT3B7,Likely Oncogenic,Likely Switch-of-function,"20587527, 23315164, 25607950, 22815530, 17353906", +DNMT3B,Amplification,Likely Oncogenic,Likely Gain-of-function,"25470049, 22810696", +RAD21,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,"28116354, 25006131", +RAD21,Deletion,Likely Oncogenic,Likely Loss-of-function,"28116354, 25006131", +RAD51C,L138F,Likely Oncogenic,Likely Loss-of-function,"24141787, 20400964", +RAD51C,A126T,Likely Neutral,Neutral,"21990120, 26261251, 20400964, 21980511", +RAD51C,R258H,Likely Oncogenic,Likely Loss-of-function,"22167183, 24141787, 20400963", +RAD51C,D159N,Likely Oncogenic,Likely Loss-of-function,"22167183, 24141787", +RAD51C,G264S,Likely Neutral,Neutral,"21990120, 26261251, 20400964", +RAD51C,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,"20400963, 20400964, 21616938", +RAD51B,HMGA2-RAD51B Fusion,Likely Oncogenic,Likely Switch-of-function,"9892177, 26787895, 11450849", +RAD51D,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,"23372765, 21822267, 22986143", +KRAS,Y64A,Oncogenic,Gain-of-function,"12628188, 26841430", +KRAS,E62K,Oncogenic,Gain-of-function,27147599, +KRAS,K117N,Oncogenic,Gain-of-function,"20570890, 20147967", +KRAS,Wildtype,Likely Neutral,Neutral,"22810696, 12506171",NCCN Colon 2.2017 https://www.nccn.org/professionals/physician_gls/pdf/colon.pdf +KRAS,Q22E,Oncogenic,Gain-of-function,"20949621, 21263000", +KRAS,G12A,Oncogenic,Gain-of-function,"26662311, 26037647, 25013473, 23182985", +KRAS,G13D,Oncogenic,Gain-of-function,"20978259, 26037647, 22722830, 20147967", +KRAS,G12R,Oncogenic,Gain-of-function,"24893629, 26037647, 21831957, 22722830", +KRAS,T74P,Likely Oncogenic,Gain-of-function,19075190, +KRAS,P34R,Oncogenic,Gain-of-function,"8995293, 17875937, 20949621, 16474405", +KRAS,L19F,Oncogenic,Gain-of-function,"17150185, 20147967", +KRAS,Q22K,Oncogenic,Gain-of-function,"23059812, 11095964, 20570890", +KRAS,A11_G12insGA,Oncogenic,Gain-of-function,24642870, +KRAS,T58I,Oncogenic,Gain-of-function,18509354, +KRAS,G12D,Oncogenic,Gain-of-function,"17349581, 24300897, 19296721, 26037647, 11751631, 15093544, 20570890, 20147967", +KRAS,N116H,Inconclusive,Inconclusive,26841430, +KRAS,R164Q,Inconclusive,Inconclusive,"26274561, 20147967", +KRAS,F28L,Oncogenic,Gain-of-function,"25600866, 20949621, 16474405", +KRAS,Q61R,Oncogenic,Gain-of-function,"21993244, 25363767, 24651010, 25437878", +KRAS,Amplification,Likely Oncogenic,Likely Gain-of-function,"23099803, 24874471, 20841479, 23404247", +KRAS,G60D,Inconclusive,Inconclusive,21632860, +KRAS,G10dup,Oncogenic,Gain-of-function,8955068, +KRAS,A59G,Oncogenic,Gain-of-function,"27147599, 1221964, 26841430", +KRAS,E31K,Likely Neutral,Likely Neutral,"20570890, 16483931", +KRAS,A146V,Likely Oncogenic,Gain-of-function,"3043178, 26841430", +KRAS,D119N,Likely Oncogenic,Likely Gain-of-function,"8552403, 11103938", +KRAS,Y40A,Inconclusive,Inconclusive,"11333268, 26841430", +KRAS,S65N,Oncogenic,Gain-of-function,"8626650, 24798740", +KRAS,G60R,Oncogenic,Gain-of-function,20949621, +KRAS,Q22R,Likely Oncogenic,Likely Gain-of-function,"20949621, 21263000", +KRAS,Y71H,Oncogenic,Gain-of-function,23059812, +KRAS,A18D,Oncogenic,Gain-of-function,19490892, +KRAS,A146T,Oncogenic,Gain-of-function,"19075190, 20570890, 20147967, 2403644", +KRAS,G12F,Likely Oncogenic,Likely Gain-of-function,20871262, +KRAS,Q61L,Oncogenic,Gain-of-function,"21993244, 25363767, 24651010, 26854029, 25437878", +KRAS,G12V,Oncogenic,Gain-of-function,"20516123, 20949621, 25359494, 20570890, 12957286, 20147967", +KRAS,G13C,Oncogenic,Gain-of-function,"25705018, 21079152", +KRAS,D33E,Oncogenic,Gain-of-function,"27147599, 24889603", +KRAS,G12C,Oncogenic,Gain-of-function,"25705018, 24256730, 16051643, 26841430", +KRAS,K5N,Oncogenic,Gain-of-function,"17875937, 20949621, 25941399", +KRAS,D153V,Oncogenic,Gain-of-function,"17875937, 20949621, 16474405, 25941399", +KRAS,G12S,Oncogenic,Gain-of-function,"26184075, 25284075", +KRAS,K147E,Oncogenic,Gain-of-function,23059812, +KRAS,LCS6-variant,Likely Oncogenic,Switch-of-function,"28006059, 25183481", +KRAS,Y32S,Likely Oncogenic,Gain-of-function,"11333268, 26841430", +KRAS,G13E,Likely Oncogenic,Likely Gain-of-function,"19453520, 26619011, 17503413, 19521964", +KRAS,V14I,Oncogenic,Gain-of-function,"25359213, 20949621, 16474405", +KRAS,Q25H,Inconclusive,Inconclusive,21375404, +KRAS,P34L,Oncogenic,Gain-of-function,"17875937, 20949621", +KRAS,Q61H,Oncogenic,Gain-of-function,"25705018, 21993244, 24651010, 20147967", +KRAS,F156L,Oncogenic,Gain-of-function,"20949621, 17601930, 7877967", +NPM1,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,"19322210, 20877721", +NPM1,Deletion,Likely Oncogenic,Likely Loss-of-function,"18212245, 19322210, 20877721, 16007073", +RAF1,ESRP1-RAF1 Fusion,Oncogenic,Gain-of-function,20526349, +RAF1,P261L,Likely Oncogenic,Likely Gain-of-function,"17603483, 20679480", +RAF1,ATG7-RAF1 Fusion,Likely Oncogenic,Likely Gain-of-function,23637631, +RAF1,S259F,Oncogenic,Gain-of-function,"17603483, 20679480", +RAF1,S427G,Oncogenic,Gain-of-function,"16585161, 19357705", +RAF1,I448V,Oncogenic,Gain-of-function,19357705, +RAF1,S257W,Likely Oncogenic,Gain-of-function,"12077328, 7867061, 17603483", +RAF1,S259P,Likely Oncogenic,Gain-of-function,20679480, +RAF1,Amplification,Oncogenic,Gain-of-function,"11389083, 21215703, 16517112",Zehir A et al. Nature Medicine 2017 http://doi:10.1038/nm.4333 +RAF1,SRGAP3-RAF1 Fusion,Oncogenic,Gain-of-function,19363522, +RAF1,S259A,Oncogenic,Gain-of-function,"24569458, 20679480", +RAF1,S257L,Oncogenic,Gain-of-function,"12077328, 7867061, 24569458, 17603483", +RAF1,Fusions,Likely Oncogenic,Likely Gain-of-function,"27810072, 19363522, 20526349, 23637631", +RAB35,F161L,Oncogenic,Gain-of-function,26338797, +RAB35,A151T,Oncogenic,Gain-of-function,26338797, +HNF1A,T196A,Likely Neutral,Neutral,21170474, +HNF1A,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,"12574234, 18003757, 25793983", +HNF1A,P291Qfs*51,Likely Oncogenic,Likely Loss-of-function,"12574234, 9313763, 16917892", +HNF1A,Deletion,Likely Oncogenic,Likely Loss-of-function,"12574234, 25793983", +AKT3,Fusions,Likely Oncogenic,Likely Gain-of-function,22722202, +AKT3,Amplification,Oncogenic,Gain-of-function,"17178867, 24138071, 18451171, 25737557, 15466193, 20647317", +AKT3,MAGI3-AKT3 Fusion,Oncogenic,Gain-of-function,22722202, +AKT3,E17K,Likely Oncogenic,Gain-of-function,18813315, +TCF3,N551K,Likely Oncogenic,Loss-of-function,"24492847, 22885699", +TCF7L2,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,"10919662, 16547505, 18478343, 18599616, 10485457", +RARA,R276W,Inconclusive,Inconclusive,"27148563, 23670176, 19865110, 11438209", +NRAS,Q61K,Oncogenic,Gain-of-function,"25277205, 21993244, 20194776, 23515407, 24651010, 19492075", +NRAS,G12D,Oncogenic,Gain-of-function,"21993244, 23687087, 24651010, 25252692, 18372904", +NRAS,G13D,Oncogenic,Gain-of-function,"26037647, 21993244, 24651010, 22722830", +NRAS,Q61H,Oncogenic,Gain-of-function,"21993244, 20194776, 23515407, 24651010", +NRAS,G12C,Likely Oncogenic,Likely Gain-of-function,"21993244, 24651010", +NRAS,G12R,Oncogenic,Gain-of-function,"21993244, 24651010", +NRAS,G13V,Likely Oncogenic,Likely Gain-of-function,"20371679, 21993244, 24651010", +NRAS,T58I,Likely Oncogenic,Likely Gain-of-function,"24265153, 16474405", +NRAS,G12V,Oncogenic,Gain-of-function,"18952898, 21993244, 21478863, 24651010", +NRAS,T50I,Likely Oncogenic,Likely Gain-of-function,"22817889, 19966803", +NRAS,G60E,Likely Oncogenic,Gain-of-function,"19075190, 19966803, 10716188, 21263000", +NRAS,Q61R,Oncogenic,Gain-of-function,"25277205, 21993244, 20194776, 23515407, 24651010, 19492075", +NRAS,Q61L,Oncogenic,Gain-of-function,"25277205, 21993244, 20194776, 23515407, 24651010, 19492075", +NRAS,Amplification,Inconclusive,Inconclusive,"26266759, 25263998, 22876308","Zehir A et al. Nature Medicine, 2017 http://doi:10.1038/nm.4333" +RASA1,Deletion,Likely Oncogenic,Likely Loss-of-function,"2173144, 9121432, 9034330, 1689011", +RASA1,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,"2173144, 9121432, 9034330, 1689011, 24038909", +RASA1,L481F,Likely Oncogenic,Likely Loss-of-function,26993606, +RASA1,Y472H,Likely Oncogenic,Likely Loss-of-function,26993606, +BCL2L11,Deletion,Oncogenic,Likely Loss-of-function,"22426421, 26076815, 23559152, 23116058", +BCL2L11,Single Nucleotide Polymorphism,Oncogenic,Loss-of-function,24223824, +BCL2L11,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,"24737648, 23382048, 26076815, 23559152, 21652541, 26001141, 23116058", +RB1,C712R,Likely Neutral,Likely Neutral,18677112, +RB1,S567L,Likely Oncogenic,Likely Loss-of-function,"10671068, 9420334", +RB1,R698W,Likely Oncogenic,Likely Loss-of-function,20594292, +RB1,R621C,Likely Oncogenic,Likely Loss-of-function,20594292, +RB1,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,"25621664, 22293180, 22205104", +RB1,C706F,Likely Oncogenic,Likely Loss-of-function,18677112, +RB1,R661W,Inconclusive,Inconclusive,"16449662, 7927327, 9420334, 1352883, 18677112", +RB1,Deletion,Likely Oncogenic,Likely Loss-of-function,"16127685, 17854503, 23960888", +RB1,N480del,Likely Neutral,Likely Neutral,18677112, +RB1,L607I,Likely Oncogenic,Likely Loss-of-function,20594292, +RB1,W563L,Inconclusive,Inconclusive,"16269091, 10882758", +RB1,V654L,Likely Oncogenic,Likely Loss-of-function,"21615945, 12541220", +KDM5A,Amplification,Likely Oncogenic,Likely Gain-of-function,"22937203, 2293720", +NTRK1,CD74-NTRK1 Fusion,Oncogenic,Gain-of-function,24162815, +NTRK1,Amplification,Likely Oncogenic,Gain-of-function,26496938, +NTRK1,Fusions,Likely Oncogenic,Likely Gain-of-function,24162815, +NTRK1,R342Q,Likely Oncogenic,Gain-of-function,"1695324, 11313867, 23000897, 23636398, 22460905", +NTRK1,NFASC-NTRK1 Fusion,Oncogenic,Gain-of-function,"24647444, 23917401", +NTRK1,LMNA-NTRK1 Fusion,Oncogenic,Gain-of-function,24445538, +NTRK1,V710A,Likely Neutral,Loss-of-function,27272783, +NTRK1,Delta-NTRK1 Fusion,Oncogenic,Gain-of-function,11073967, +NTRK1,TFG-NTRK1 Fusion,Oncogenic,Gain-of-function,"7565764, 16256137, 9488046", +NTRK1,TRKAIII Splice Variant,Oncogenic,Gain-of-function,15488758, +NTRK1,R342W,Likely Oncogenic,Gain-of-function,"1695324, 11313867, 23636398, 22460905", +NTRK1,TPM3-NTRK1 Fusion,Oncogenic,Gain-of-function,"2869410, 7590742, 25204415, 24705251, 16483615, 10074915, 2927393, 16256137, 25384085, 24962792", +NTRK1,MPRIP-NTRK1 Fusion,Oncogenic,Gain-of-function,24162815, +NTRK1,TPR-NTRK1 Fusion,Oncogenic,Gain-of-function,"9172002, 16483615, 10074915, 1532241, 7851906", +NTRK2,M713I,Likely Neutral,Likely Loss-of-function,21242122, +NTRK2,R715G,Likely Neutral,Likely Neutral,21242122, +NTRK2,R734C,Likely Neutral,Likely Loss-of-function,21242122, +NTRK2,Fusions,Likely Oncogenic,Likely Gain-of-function,"26565381, 25204415, 26216294, 26884591, 24647444, 24445538, 26457764, 26797418, 24162815, 27843590, 26603524", +NTRK3,ETV6-NTRK3 Fusion,Oncogenic,Gain-of-function,"21401966, 9823307, 9462753, 24705251, 25207766, 23583981, 24135138, 10702799, 10895816, 24327398, 12450792, 11801301", +NTRK3,G608S,Likely Neutral,Likely Neutral,23874207, +NTRK3,BTBD1-NTRK3 Fusion,Oncogenic,Gain-of-function,24705251, +NTRK3,G623R,Inconclusive,Inconclusive,26884591, +NTRK3,Fusions,Likely Oncogenic,Likely Gain-of-function,"26565381, 25204415, 26216294, 26884591, 27843950, 26457764, 26797418, 27148571, 26603524", +DUSP4,Deletion,Inconclusive,Inconclusive,"21317287, 19525976", +DDR2,L239R,Oncogenic,Gain-of-function,"22328973, 23335507", +DDR2,S768R,Likely Oncogenic,Likely Gain-of-function,"22328973, 25173530", +DDR2,G253C,Oncogenic,Gain-of-function,"22328973, 23335507", +DDR2,L63V,Oncogenic,Gain-of-function,"23822953, 22328973", +DDR2,G774V,Oncogenic,Gain-of-function,22328973, +DDR2,Amplification,Likely Oncogenic,Likely Gain-of-function,"24505276, 26362312, 28099935", +DDR2,G505S,Likely Oncogenic,Gain-of-function,"23822953, 22328973", +DDR2,I638F,Inconclusive,Inconclusive,"23822953, 22328973", +DDR2,T654M,Inconclusive,Inconclusive,"22328973, 24296828", +DDR2,T654I,Inconclusive,Inconclusive,24296828, +SOX17,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,"22588877, 28237397, 17875931, 23550210, 27738313", +SOX17,Deletion,Likely Oncogenic,Likely Loss-of-function,"17655922, 28237397, 24407731, 20716954, 17875931, 18413743, 19301122, 27738313, 21514720, 24153254, 27102016, 22846201", +NSD1,Fusions,Likely Oncogenic,Likely Gain-of-function,"11895789, 23630019, 27889185", +NSD1,NSD1-NUP98 Fusion,Likely Oncogenic,Likely Gain-of-function,"11895789, 23630019", +CASP8,G325A,Likely Oncogenic,Gain-of-function,23659359, +CASP8,Promoter Hypermethylation,Likely Oncogenic,Loss-of-function,"16397500, 10969767, 11593392", +CASP8,C248T,Likely Neutral,Neutral,12353035, +CASP8,Deletion,Likely Oncogenic,Likely Loss-of-function,"15531912, 12055196, 15705878", +CASP8,CASP8L,Likely Oncogenic,Loss-of-function,"12010809, 10860845, 15735742, 16374545", +CASP8,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,"15531912, 19852930, 15705878, 12949717", +RET,Fusions,Likely Oncogenic,Likely Gain-of-function,"25064355, 24561444, 22327623", +RET,E768D,Likely Oncogenic,Likely Gain-of-function,10445857, +RET,V804G,Likely Neutral,Likely Loss-of-function,15184865, +RET,M918V,Likely Oncogenic,Likely Gain-of-function,21810974, +RET,K603Q,Likely Oncogenic,Likely Gain-of-function,"15277225, 11746981", +RET,D631_L633delinsE,Likely Oncogenic,Likely Gain-of-function,"9191060, 15858153, 27082517",NCCN Thyroid Cancer volume 1.2017 https://www.nccn.org/professionals/physician_gls/pdf/thyroid.pdf +RET,C620R,Oncogenic,Gain-of-function,9230192, +RET,C609Y,Oncogenic,Gain-of-function,9230192, +RET,V648I,Likely Neutral,Likely Neutral,21810974, +RET,C634R,Oncogenic,Gain-of-function,9230192, +RET,S904F,Likely Oncogenic,Likely Gain-of-function,21810974, +RET,A883F,Oncogenic,Gain-of-function,24561444, +RET,M980T,Likely Neutral,Likely Neutral,11438491, +RET,M848T,Likely Oncogenic,Likely Gain-of-function,21810974, +RET,E632_L633del,Likely Oncogenic,Gain-of-function,9191060, +RET,D631N,Likely Neutral,Likely Neutral,10049754, +RET,R886W,Oncogenic,Gain-of-function,21551259, +RET,D631A,Likely Neutral,Likely Neutral,10049754, +RET,A919P,Inconclusive,Inconclusive,16928683, +RET,C630R,Oncogenic,Gain-of-function,9230192, +RET,A883T,Oncogenic,Gain-of-function,"15531548, 21810974", +RET,Y806C,Likely Oncogenic,Likely Gain-of-function,19029224, +RET,G885R,Likely Neutral,Likely Neutral,"25733075, 24336963", +RET,D631G,Likely Neutral,Likely Neutral,10049754, +RET,Y791F,Likely Oncogenic,Gain-of-function,"15753368, 9506724, 12490841, 17209045", +RET,V804L,Likely Oncogenic,Likely Gain-of-function,"15184865, 9242375", +RET,A919V,Likely Oncogenic,Likely Gain-of-function,19186126, +RET,RET-CCDC6 Fusion,Oncogenic,Gain-of-function,23578175, +RET,T338I,Likely Neutral,Likely Neutral,21810974, +RET,D631Y,Likely Oncogenic,Gain-of-function,10049754, +RET,R897Q,Likely Neutral,Loss-of-function,11438491, +RET,C634S,Likely Oncogenic,Gain-of-function,15277225, +RET,R833C,Likely Oncogenic,Likely Gain-of-function,21810974, +RET,E921K,Likely Neutral,Loss-of-function,11438491, +RET,V804M,Oncogenic,Gain-of-function,17047083, +RET,S765P,Likely Neutral,Loss-of-function,11438491, +RET,C618R,Oncogenic,Gain-of-function,9230192, +RET,E511K,Likely Oncogenic,Likely Gain-of-function,"20103606, 21551259", +RET,S891A,Oncogenic,Gain-of-function,"24561444, 20554711", +RET,KIF5B-RET Fusion,Oncogenic,Gain-of-function,22327624, +RET,C611Y,Oncogenic,Gain-of-function,9230192, +RET,R873Q,Likely Neutral,Loss-of-function,11438491, +RET,F893L,Likely Neutral,Loss-of-function,11438491, +RET,C634W,Likely Oncogenic,Likely Gain-of-function,"17664273, 9230192", +RET,L790F,Oncogenic,Gain-of-function,"20444924, 15753368", +RET,I852M,Likely Oncogenic,Likely Gain-of-function,"21711375, 11295841", +RET,M918T,Oncogenic,Gain-of-function,"8755580, 22584710, 7824936, 9681850, 24561444", +RET,C634Y,Likely Oncogenic,Gain-of-function,9230192, +RUNX1,S70fsX93,Oncogenic,Loss-of-function,18192504, +RUNX1,H78Q,Likely Oncogenic,Loss-of-function,22318203, +RUNX1,Fusions,Likely Oncogenic,Likely Loss-of-function,21174539, +RUNX1,Amplification,Oncogenic,Gain-of-function,25592647, +RUNX1,D171G,Likely Oncogenic,Likely Loss-of-function,22318203, +RUNX1,K83N,Likely Oncogenic,Loss-of-function,"11830488, 15156185", +RUNX1,TEL-RUNX1 Fusion,Likely Oncogenic,Loss-of-function,15156184, +RUNX1,R166Q,Likely Oncogenic,Loss-of-function,10508512, +RUNX1,S291fsX300,Oncogenic,Loss-of-function,18192504, +RUNX1,R80C,Likely Oncogenic,Loss-of-function,15156185, +RUNX1,R177Q,Oncogenic,Loss-of-function,"11830488, 18192504", +RUNX1,R177*,Oncogenic,Loss-of-function,"10068652, 11830488, 15156185", +RUNX1,K83E,Likely Oncogenic,Loss-of-function,"11830488, 15156185", +RUNX1,R174Q,Oncogenic,Loss-of-function,"25490895, 21725049, 17290219", +RUNX1,P173S,Oncogenic,Loss-of-function,18192504, +RUNX1,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,"15864279, 15386419, 17394134", +RUNX1,R201Q,Likely Oncogenic,Loss-of-function,10508512, +RUNX1,W279*,Likely Oncogenic,Likely Loss-of-function,25893166, +RUNX1,RUNX1-RUNX1T1 Fusion,Likely Oncogenic,Loss-of-function,"19414342, 21174539, 4125056, 9819404", +RUNX1,RUNX1-EVI1 Fusion,Likely Oncogenic,Loss-of-function,"15156182, 19016745", +RUNX1,G42R,Inconclusive,Inconclusive,"18192504, 12874780, 12393679", +RUNX1,D171N,Oncogenic,Loss-of-function,"18192504, 12393679", +RUNX1,Y113*,Oncogenic,Loss-of-function,18192504, +RUNX1,R139G,Likely Oncogenic,Loss-of-function,22318203, +RUNX1,A122*,Likely Oncogenic,Likely Loss-of-function,18192504, +RUNX1,R174*,Oncogenic,Gain-of-function,"26021490, 20549580", diff --git a/synapse_tmp.csv b/synapse_tmp.csv old mode 100644 new mode 100755