diff --git a/deploy/charts/mysql-operator/templates/statefulset.yaml b/deploy/charts/mysql-operator/templates/statefulset.yaml
index 2ff2e4c05..123c3d828 100644
--- a/deploy/charts/mysql-operator/templates/statefulset.yaml
+++ b/deploy/charts/mysql-operator/templates/statefulset.yaml
@@ -156,9 +156,19 @@ spec:
       nodeSelector:
         {{- toYaml . | nindent 8 }}
       {{- end }}
-      {{- with .Values.affinity }}
+      {{- if gt (int .Values.replicaCount) 1 }}
       affinity:
-        {{- toYaml . | nindent 8 }}
+        podAntiAffinity:
+          preferredDuringSchedulingIgnoredDuringExecution:
+            - weight: 1
+              podAffinityTerm:
+                labelSelector:
+                  matchLabels:
+                    {{ include "mysql-operator.selectorLabels" . | nindent 20 }}
+                topologyKey: kubernetes.io/hostname
+      {{- else if .Values.affinity }}
+      affinity:
+        {{- toYaml .Values.affinity | nindent 8 }}
       {{- end }}
       {{- with .Values.tolerations }}
       tolerations: