Feature request: Reference-corrected VPC

[billdenney]

I just saw this article about reference-corrected VPCs (a cousin of prediction-corrected VPCs). It would be useful to have them implemented as part of tidyvpc.

https://link.springer.com/article/10.1208/s12248-025-01065-2

[certara-jcraig]

Hi @billdenney , thanks for the suggestion - agree, the methodology would indeed be useful to offer in tidyvpc, I can envision something like:

vpc <- observed(obs_data, x = TIME, y = DV) %>%
  simulated(sim_data, y = DV) %>%
  refcorrect(pred = PRED, data_ref = ref_data, lb = lb, log = FALSE) %>%
  binning(bin = NTIME) %>%
  vpcstats()

I collaborated with a few of our scientists in CDDS and Jeff Sachs from Merck on another transformation/correction methodology, VACHETTE, which we've developed into a package: https://certara.github.io/vachette/index.html.

We also have a forthcoming publication and examples of how to use the vachette transformations for VPC.
https://certara.github.io/vachette/articles/vachette_examples.html#vpc

I'd ultimately like to provide support for both refcorrect and vachettecorrect in the package and make tidyvpc even more capable! I will plan to add this to the roadmap - don't hesitate to provide any further suggestions or feedback.

Best,
James