diff --git a/pyproject.toml b/pyproject.toml
index ea63994..39a6931 100644
--- a/pyproject.toml
+++ b/pyproject.toml
@@ -26,6 +26,7 @@ dynamic = ["version"]
 
 dependencies = [
     "pythonnet>=3.0.1",
+    "pythoncom>=308; os_name == 'nt'",
 ]
 
 [project.optional-dependencies]
diff --git a/src/pyrenode3/inits.py b/src/pyrenode3/inits.py
index 3e93ad6..0ab8115 100644
--- a/src/pyrenode3/inits.py
+++ b/src/pyrenode3/inits.py
@@ -1,6 +1,9 @@
 import atexit
 import time
 from threading import Thread
+import os
+if os.name == "nt"
+    import pythoncom
 
 from Antmicro.Renode import Emulator
 from Antmicro.Renode.Analyzers import LoggingUartAnalyzer
@@ -46,6 +49,16 @@ def __clean(self):
             c()
 
 
+def start_main_thread():
+    """ start ExecuteAsMainThread """
+    if os.name == "nt":
+        pythoncom.CoInitializeEx(pythoncom.COINIT_APARTMENTTHREADED)
+        Emulator.ExecuteAsMainThread()
+        pythoncom.CoUninitialize()
+    else:
+        Emulator.ExecuteAsMainThread()
+    
+
 class EmulatorInit(metaclass=MetaSingleton):
     """A class used for initializing the emulator."""
 
@@ -54,7 +67,7 @@ def __init__(self):
 
         Emulator.ShowAnalyzers = True
 
-        self.__thread = Thread(target=Emulator.ExecuteAsMainThread, daemon=True)
+        self.__thread = Thread(target=start_main_thread, daemon=True)
         self.__thread.start()
 
         Cleaner().add_multiple(