diff --git a/packages/block-library/src/utils/poster-image.js b/packages/block-library/src/utils/poster-image.js
index eeb694f571a21f..cce9d4ec02ba8c 100644
--- a/packages/block-library/src/utils/poster-image.js
+++ b/packages/block-library/src/utils/poster-image.js
@@ -6,26 +6,73 @@ import clsx from 'clsx';
 /**
  * WordPress dependencies
  */
-import { MediaUpload, MediaUploadCheck } from '@wordpress/block-editor';
+import {
+	MediaUpload,
+	MediaUploadCheck,
+	store as blockEditorStore,
+} from '@wordpress/block-editor';
+import { store as noticesStore } from '@wordpress/notices';
 import {
 	Button,
 	BaseControl,
+	DropZone,
+	Spinner,
 	__experimentalHStack as HStack,
 	__experimentalToolsPanelItem as ToolsPanelItem,
 } from '@wordpress/components';
+import { isBlobURL } from '@wordpress/blob';
 import { __, sprintf } from '@wordpress/i18n';
-import { useRef } from '@wordpress/element';
+import { useRef, useState } from '@wordpress/element';
 import { useInstanceId } from '@wordpress/compose';
+import { useSelect, useDispatch } from '@wordpress/data';
 
 const POSTER_IMAGE_ALLOWED_MEDIA_TYPES = [ 'image' ];
 
 function PosterImage( { poster, onChange } ) {
 	const posterButtonRef = useRef();
+	const [ isLoading, setIsLoading ] = useState( false );
 	const descriptionId = useInstanceId(
 		PosterImage,
 		'block-library-poster-image-description'
 	);
 
+	const { getSettings } = useSelect( blockEditorStore );
+	const { createErrorNotice } = useDispatch( noticesStore );
+
+	const onDropFiles = ( filesList ) => {
+		getSettings().mediaUpload( {
+			allowedTypes: POSTER_IMAGE_ALLOWED_MEDIA_TYPES,
+			filesList,
+			onFileChange: ( [ image ] ) => {
+				if ( isBlobURL( image?.url ) ) {
+					setIsLoading( true );
+					return;
+				}
+
+				if ( image ) {
+					onChange( image );
+				}
+				setIsLoading( false );
+			},
+			onError: ( message ) => {
+				createErrorNotice( message, {
+					id: 'poster-image-upload-notice',
+					type: 'snackbar',
+				} );
+				setIsLoading( false );
+			},
+			multiple: false,
+		} );
+	};
+
+	const getPosterButtonContent = () => {
+		if ( ! poster && isLoading ) {
+			return <Spinner />;
+		}
+
+		return ! poster ? __( 'Set poster image' ) : __( 'Replace' );
+	};
+
 	return (
 		<MediaUploadCheck>
 			<ToolsPanelItem
@@ -48,24 +95,19 @@ function PosterImage( { poster, onChange } ) {
 									__next40pxDefaultSize
 									onClick={ open }
 									aria-haspopup="dialog"
-									aria-label={
-										! poster
-											? null
-											: __(
-													'Edit or replace the poster image.'
-											  )
-									}
-									className={
-										poster
-											? 'block-library-poster-image__preview'
-											: 'block-library-poster-image__toggle'
-									}
+									aria-label={ __(
+										'Edit or replace the poster image.'
+									) }
+									className="block-library-poster-image__preview"
+									disabled={ isLoading }
+									accessibleWhenDisabled
 								>
 									<img
 										src={ poster }
 										alt={ __( 'Poster image preview' ) }
 										className="block-library-poster-image__preview-image"
 									/>
+									{ isLoading && <Spinner /> }
 								</Button>
 							) }
 							<HStack
@@ -87,10 +129,10 @@ function PosterImage( { poster, onChange } ) {
 									variant={
 										! poster ? 'secondary' : undefined
 									}
+									disabled={ isLoading }
+									accessibleWhenDisabled
 								>
-									{ ! poster
-										? __( 'Set poster image' )
-										: __( 'Replace' ) }
+									{ getPosterButtonContent() }
 								</Button>
 								<p id={ descriptionId } hidden>
 									{ poster
@@ -115,11 +157,14 @@ function PosterImage( { poster, onChange } ) {
 											posterButtonRef.current.focus();
 										} }
 										className="block-library-poster-image__action"
+										disabled={ isLoading }
+										accessibleWhenDisabled
 									>
 										{ __( 'Remove' ) }
 									</Button>
 								) }
 							</HStack>
+							<DropZone onFilesDrop={ onDropFiles } />
 						</div>
 					) }
 				/>
diff --git a/packages/block-library/src/utils/poster-image.scss b/packages/block-library/src/utils/poster-image.scss
index 0d16fabb1c2b9f..f6d03e24dc2559 100644
--- a/packages/block-library/src/utils/poster-image.scss
+++ b/packages/block-library/src/utils/poster-image.scss
@@ -13,9 +13,31 @@
 		opacity: 1;
 		margin-top: $grid-unit-20;
 	}
+
+	.components-drop-zone__content {
+		border-radius: $radius-small;
+	}
+
+	// Align text and icons horizontally to avoid clipping when the poster image is not set.
+	.components-drop-zone .components-drop-zone__content-inner {
+		display: flex;
+		align-items: center;
+		gap: $grid-unit-10;
+
+		.components-drop-zone__content-icon {
+			margin: 0;
+		}
+	}
+
+	.components-spinner {
+		position: absolute;
+		top: 50%;
+		left: 50%;
+		margin-top: -9px;
+		margin-left: -9px;
+	}
 }
 
-.block-library-poster-image__toggle,
 .block-library-poster-image__preview {
 	width: 100%;
 	padding: 0;
@@ -25,9 +47,6 @@
 
 	display: flex;
 	justify-content: center;
-}
-
-.block-library-poster-image__preview {
 	height: auto !important;
 	outline: $border-width solid rgba($black, 0.1);
 
@@ -39,18 +58,6 @@
 	}
 }
 
-.block-library-poster-image__toggle {
-	box-shadow: inset 0 0 0 $border-width $gray-400;
-
-	&:focus:not(:disabled) {
-		// Allow smooth transition between focused and unfocused box-shadow states.
-		box-shadow:
-			0 0 0 currentColor inset,
-			0 0 0 var(--wp-admin-border-width-focus)
-			var(--wp-admin-theme-color);
-	}
-}
-
 .block-library-poster-image__actions {
 	&:not(.block-library-poster-image__actions-select) {
 		bottom: 0;