Would you support splitting out into a separate package:
class MonadI2C m where
writeI2C :: Address -> ByteString -> m ()
readI2C :: Address -> Int -> m ByteString
writeReadI2C :: Address -> ByteString -> Int -> m ByteString
(Or possibly similar types that provide a bit more feedback in the case of errors?)
If that package existed (I can write it up and put it on hackage) and this package provided an instance of it for raspberry pi, then device drivers for I2C slaves could be written without taking a direct dependency on the HPi package but could still be used with it.
(There could be another similar monad for SPI communications.)