There's no information about a limit of a number of columns and indexes in Starcounter, but some people already hit these. This should be explicitly said in appropriate places in the database section of the documentation.
Limit of number of columns: 127 (should be checked with core team)
Limit of number of indexes per table: 32 (but it is a bit more complicated than that because of inheritance and implicitly created indexes). Should be precisely checked.