When a settings configuration exceeds PT's allowable size, PTMagic throws a 404 error, and the configs are not updated.
This usually happens when using a large number of SMS Settings that have multiple lines modifying coin-specifc settings. For every coin with an SMS setting applied, a group of lines is added to the config settings for those coins.
One way to address this would be to NOT write settings for coins that are not listed in the PBL.