Summary of Dundee DMPK Data for OSM Compounds #40
Description
This issue collates DMPK data generated by Dundee for selected OSM compounds, as part of a collaborative effort coordinated by Lauren Webster and colleagues. The dataset includes:
🧪 DMPK Summary from Dundee for OSM Compounds
| DDDID | Batch | DNDi ID | Purity (%) | Solubility (µM) | CHI logD | HepG2 pIC₅₀ | Microsomal Clearance (mL/min/mg) | T½ (min) |
|---|---|---|---|---|---|---|---|---|
| DDD00115078 | 3 | OSM-S-106 | 99 | 19.6 | — | 4.21 | 0.079075 | 17.53 |
| DDD02590662 | 1 | OSM-LO-80 | 99 | NR | — | 4.67 | 0.099054 | 13.99 |
| DDD02590664 | 1 | OSM-LO-87 | 99 | 16.9 | — | <4 | 0.152101 | 9.11 |
NR = Not Reported; “<4” in pIC₅₀ = low cytotoxicity
A summary diagram visualising these measurements is included below to assist with comparison across compounds.
📎 The original PowerPoint presentation detailing experimental methods and conditions is attached for reference. This also lists relevant contributors and provides additional context to help confirm units and interpret thresholds.
This data has been added to the local GitHub repo and will sync automatically.
🔗 A link to this issue will also be added to the wiki for easy access under the 2024 DMPK Results section.