diff --git a/src/scripts/clipperUI/mainController.tsx b/src/scripts/clipperUI/mainController.tsx
index ec8c533a..7f487ce8 100644
--- a/src/scripts/clipperUI/mainController.tsx
+++ b/src/scripts/clipperUI/mainController.tsx
@@ -104,6 +104,25 @@ export class MainControllerClass extends ComponentBase<MainControllerState, Main
 			onBeforeAnimateOut: () => { this.setState({currentPanel: PanelType.None}); },
 			onBeforeAnimateIn: () => { this.props.clipperState.reset(); },
 			onAnimateInExpand: () => { this.setState({currentPanel: this.getPanelTypeToShow()}); },
+			onAfterAnimateIn: (el: HTMLElement) => {
+				// Set focus to the clipper when it opens for accessibility (MAS 2.4.3 - Focus Order)
+				// Find the first tabbable element and focus on it
+				let tabbables = el.querySelectorAll("[tabindex]");
+				let lowestTabIndexElement: HTMLElement;
+				if (tabbables.length > 0) {
+					for (let i = 0; i < tabbables.length; i++) {
+						let tabbable = tabbables[i] as HTMLElement;
+						if (!lowestTabIndexElement || tabbable.tabIndex < lowestTabIndexElement.tabIndex) {
+							if (tabbable.tabIndex >= 0) {
+								lowestTabIndexElement = tabbable;
+							}
+						}
+					}
+					if (lowestTabIndexElement) {
+						lowestTabIndexElement.focus();
+					}
+				}
+			},
 			onAfterAnimateOut: () => { Clipper.getInjectCommunicator().callRemoteFunction(Constants.FunctionKeys.hideUi); }
 		});
 
diff --git a/src/scripts/extensions/clipperInject.ts b/src/scripts/extensions/clipperInject.ts
index 8a66cd3d..ed83e3b7 100644
--- a/src/scripts/extensions/clipperInject.ts
+++ b/src/scripts/extensions/clipperInject.ts
@@ -134,6 +134,20 @@ export class ClipperInject extends FrameInjectBase<ClipperInjectOptions> {
 					}
 				}
 			};
+
+			// Set focus to the iframe on initial invocation to ensure keyboard users can access it
+			// immediately, regardless of how the extension was invoked (MAS 2.4.3 - Focus Order)
+			// Use both requestAnimationFrame and setTimeout to handle different browser behaviors
+			requestAnimationFrame(() => {
+				// First, try to move focus from browser chrome to the page content
+				// This is necessary when invoked via keyboard from extensions list
+				window.focus();
+
+				setTimeout(() => {
+					// Then focus the iframe
+					this.frame.focus();
+				}, 50);
+			});
 		} catch (e) {
 			this.handleConstructorError(e);
 			throw e;
@@ -185,6 +199,20 @@ export class ClipperInject extends FrameInjectBase<ClipperInjectOptions> {
 		this.frame = StyledFrameFactory.getStyledFrame(Frame.WebClipper);
 		this.frame.id = Constants.Ids.clipperUiFrame;
 		this.frame.src = this.options.frameUrl;
+		// Set tabindex to make iframe focusable for keyboard accessibility (MAS 2.4.3 - Focus Order)
+		this.frame.tabIndex = -1;
+
+		// Add onload handler to focus the iframe once content is loaded
+		// This ensures focus transfer works even when invoked from browser chrome
+		this.frame.onload = () => {
+			// First, try to move focus from browser chrome to the page content
+			window.focus();
+
+			// Small delay to ensure browser chrome has released focus
+			setTimeout(() => {
+				this.frame.focus();
+			}, 100);
+		};
 	}
 
 	protected handleConstructorError(e: Error) {
@@ -375,6 +403,15 @@ export class ClipperInject extends FrameInjectBase<ClipperInjectOptions> {
 	private toggleClipper() {
 		if (this.frame.style.display === "none") {
 			this.frame.style.display = "";
+			// Set focus to the iframe when showing it to ensure focus moves from browser chrome
+			// This enables keyboard users to access the clipper immediately (MAS 2.4.3 - Focus Order)
+			// First move focus to page, then to iframe
+			window.focus();
+
+			// Use setTimeout to ensure the iframe is fully visible before focusing
+			setTimeout(() => {
+				this.frame.focus();
+			}, 50);
 		}
 		this.uiCommunicator.callRemoteFunction(Constants.FunctionKeys.toggleClipper);
 	}