diff --git a/app/components/Views/BrowserTab/BrowserTab.tsx b/app/components/Views/BrowserTab/BrowserTab.tsx
index 81d8af2fa43b..9ea8ba551aca 100644
--- a/app/components/Views/BrowserTab/BrowserTab.tsx
+++ b/app/components/Views/BrowserTab/BrowserTab.tsx
@@ -77,7 +77,8 @@ import { useMetrics } from '../../../components/hooks/useMetrics';
 import { trackDappViewedEvent } from '../../../util/metrics';
 import trackErrorAsAnalytics from '../../../util/metrics/TrackError/trackErrorAsAnalytics';
 import { selectPermissionControllerState } from '../../../selectors/snaps/permissionController';
-import { isTest } from '../../../util/test/utils.js';
+import { isTest, isE2E } from '../../../util/test/utils.js';
+import EntryScriptProxyE2E from '../../../core/EntryScriptProxyE2E';
 import { EXTERNAL_LINK_TYPE } from '../../../constants/browser';
 import { useNavigation } from '@react-navigation/native';
 import { useStyles } from '../../hooks/useStyles';
@@ -519,8 +520,14 @@ export const BrowserTab: React.FC<BrowserTabProps> = React.memo(
 
       const getEntryScriptWeb3 = async () => {
         const entryScriptWeb3Fetched = await EntryScriptWeb3.get();
+
+        // In E2E mode, inject the proxy script FIRST to intercept all fetch/XHR calls
+        // This must run before any page scripts to ensure all requests are proxied
+        const e2eProxyScript = isE2E ? EntryScriptProxyE2E.get() : '';
+
         setEntryScriptWeb3(
-          entryScriptWeb3Fetched +
+          e2eProxyScript +
+            entryScriptWeb3Fetched +
             SPA_urlChangeListener +
             SCROLL_TRACKER_SCRIPT,
         );
@@ -1554,6 +1561,14 @@ export const BrowserTab: React.FC<BrowserTabProps> = React.memo(
                         onFileDownload={handleOnFileDownload}
                         webviewDebuggingEnabled={isTest}
                         paymentRequestEnabled
+                        // E2E Testing: Enable native request interception on Android
+                        // @ts-expect-error - Custom E2E props not in WebView types
+                        e2eMode={isE2E}
+                        mockServerUrl={
+                          isE2E
+                            ? EntryScriptProxyE2E.getMockServerUrl()
+                            : undefined
+                        }
                       />
                       {ipfsBannerVisible && (
                         <IpfsBanner
diff --git a/app/core/EntryScriptProxyE2E.ts b/app/core/EntryScriptProxyE2E.ts
new file mode 100644
index 000000000000..8938b268200d
--- /dev/null
+++ b/app/core/EntryScriptProxyE2E.ts
@@ -0,0 +1,263 @@
+import { Platform } from 'react-native';
+import { LaunchArguments } from 'react-native-launch-arguments';
+import {
+  isE2E,
+  FALLBACK_COMMAND_QUEUE_SERVER_PORT,
+  testConfig,
+} from '../util/test/utils';
+import { defaultMockPort } from '../../tests/api-mocking/mock-config/mockUrlCollection.json';
+
+// Fallback port for mock server - same pattern as FixtureServer
+// Android: Uses fallback port (adb reverse maps it to actual port)
+// iOS: Uses actual port from LaunchArguments
+const FALLBACK_MOCKSERVER_PORT = defaultMockPort || 8000;
+
+/**
+ * The E2E proxy script that gets injected into the WebView.
+ * This script patches fetch and XMLHttpRequest to route through the mock server.
+ *
+ * This is embedded directly rather than loaded from a file to avoid
+ * complex build configuration changes.
+ */
+const INPAGE_PROXY_SCRIPT = `
+(function () {
+  'use strict';
+
+  // Check if E2E config is available
+  if (!window.__E2E_MOCK_CONFIG__) {
+    return;
+  }
+
+  var config = window.__E2E_MOCK_CONFIG__;
+  var mockServerPort = config.mockServerPort;
+  var isAndroid = config.isAndroid;
+  var commandQueueServerPort = config.commandQueueServerPort;
+
+  var originalFetch = window.fetch;
+  var OriginalXHR = window.XMLHttpRequest;
+
+  // Try multiple hosts to find available mock server
+  var hosts = ['localhost'];
+  if (isAndroid) {
+    hosts.push('10.0.2.2');
+  }
+
+  var MOCKTTP_URL = '';
+  var isMockServerAvailable = false;
+
+  function isLocalUrl(url) {
+    try {
+      var parsed = new URL(url);
+      return (
+        parsed.hostname === 'localhost' ||
+        parsed.hostname === '127.0.0.1' ||
+        parsed.hostname === '10.0.2.2'
+      );
+    } catch (e) {
+      return false;
+    }
+  }
+
+  function isCommandQueueUrl(url) {
+    try {
+      var parsed = new URL(url);
+      return (
+        isLocalUrl(url) && parsed.port === String(commandQueueServerPort)
+      );
+    } catch (e) {
+      return false;
+    }
+  }
+
+  function isMockServerUrl(url) {
+    return (
+      url.includes('localhost:' + mockServerPort) ||
+      url.includes('10.0.2.2:' + mockServerPort) ||
+      url.includes('/proxy')
+    );
+  }
+
+  (async function init() {
+    for (var i = 0; i < hosts.length; i++) {
+      var host = hosts[i];
+      var testUrl = 'http://' + host + ':' + mockServerPort;
+
+      try {
+        var res = await originalFetch(testUrl + '/health-check');
+        if (res.ok) {
+          MOCKTTP_URL = testUrl;
+          isMockServerAvailable = true;
+          console.log('[E2E WebView] Mock server connected via ' + host);
+          break;
+        }
+      } catch (e) {
+        console.log('[E2E WebView] ' + host + ' health check failed: ' + e.message);
+      }
+    }
+
+    if (!isMockServerAvailable) {
+      console.warn('[E2E WebView] Mock server not available, using original fetch');
+      return;
+    }
+
+    // Patch fetch
+    window.fetch = async function (url, options) {
+      var urlString;
+      if (typeof url === 'string') {
+        urlString = url;
+      } else if (url instanceof URL) {
+        urlString = url.href;
+      } else if (url && typeof url === 'object' && url.url) {
+        urlString = url.url;
+      } else {
+        urlString = String(url);
+      }
+
+      if (isCommandQueueUrl(urlString) || isMockServerUrl(urlString)) {
+        return originalFetch(url, options);
+      }
+
+      if (urlString.startsWith('http://') || urlString.startsWith('https://')) {
+        try {
+          return await originalFetch(
+            MOCKTTP_URL + '/proxy?url=' + encodeURIComponent(urlString),
+            options
+          );
+        } catch (e) {
+          return originalFetch(url, options);
+        }
+      }
+
+      return originalFetch(url, options);
+    };
+
+    // Patch XMLHttpRequest
+    if (OriginalXHR) {
+      window.XMLHttpRequest = function () {
+        var xhr = new OriginalXHR();
+        var originalOpen = xhr.open;
+
+        xhr.open = function (method, url) {
+          var openArgs = Array.prototype.slice.call(arguments, 2);
+
+          try {
+            if (
+              typeof url === 'string' &&
+              (url.startsWith('http://') || url.startsWith('https://'))
+            ) {
+              if (isCommandQueueUrl(url) || isMockServerUrl(url)) {
+                return originalOpen.apply(this, [method, url].concat(openArgs));
+              }
+              url = MOCKTTP_URL + '/proxy?url=' + encodeURIComponent(url);
+            }
+            return originalOpen.apply(this, [method, url].concat(openArgs));
+          } catch (error) {
+            return originalOpen.apply(this, [method, url].concat(openArgs));
+          }
+        };
+
+        return xhr;
+      };
+
+      try {
+        Object.setPrototypeOf(window.XMLHttpRequest, OriginalXHR);
+        Object.assign(window.XMLHttpRequest, OriginalXHR);
+        window.__E2E_XHR_PATCHED = true;
+        console.log('[E2E WebView] Successfully patched XMLHttpRequest');
+      } catch (error) {
+        console.warn('[E2E WebView] Failed to copy XHR properties:', error);
+        window.XMLHttpRequest = OriginalXHR;
+      }
+    }
+
+    console.log('[E2E WebView] Fetch and XHR patching complete');
+  })();
+})();
+`;
+
+interface LaunchArgsType {
+  mockServerPort?: string;
+  commandQueueServerPort?: string;
+}
+
+interface TestConfigType {
+  fixtureServerPort?: number;
+  commandQueueServerPort?: number;
+}
+
+const EntryScriptProxyE2E = {
+  cachedScript: null as string | null,
+  cachedMockServerUrl: null as string | null,
+
+  /**
+   * Get the mock server port based on platform.
+   * Android: Uses fallback port (adb reverse maps to actual)
+   * iOS: Uses actual port from LaunchArguments
+   */
+  getMockServerPort(): number {
+    const raw = LaunchArguments.value() as LaunchArgsType;
+    return Platform.OS === 'android'
+      ? FALLBACK_MOCKSERVER_PORT
+      : Number(raw?.mockServerPort ?? FALLBACK_MOCKSERVER_PORT);
+  },
+
+  /**
+   * Get the mock server URL for native WebView interception.
+   * Returns the URL that the native code should use to proxy requests.
+   */
+  getMockServerUrl(): string | undefined {
+    if (!isE2E) {
+      return undefined;
+    }
+
+    if (this.cachedMockServerUrl) {
+      return this.cachedMockServerUrl;
+    }
+
+    const port = this.getMockServerPort();
+    // Use localhost for both platforms - adb reverse handles Android mapping
+    this.cachedMockServerUrl = `http://localhost:${port}`;
+    return this.cachedMockServerUrl;
+  },
+
+  /**
+   * Get the E2E proxy script with configuration prepended.
+   * Returns empty string if not in E2E mode.
+   */
+  get(): string {
+    // Only return script in E2E mode
+    if (!isE2E) {
+      return '';
+    }
+
+    // Return cached if available
+    if (this.cachedScript) {
+      return this.cachedScript;
+    }
+
+    const mockServerPort = this.getMockServerPort();
+    const commandQueueServerPort =
+      (testConfig as TestConfigType).commandQueueServerPort ??
+      FALLBACK_COMMAND_QUEUE_SERVER_PORT;
+
+    // Create the configuration that will be injected before the script
+    const config = `window.__E2E_MOCK_CONFIG__ = {
+  mockServerPort: ${mockServerPort},
+  isAndroid: ${Platform.OS === 'android'},
+  commandQueueServerPort: ${commandQueueServerPort}
+};`;
+
+    this.cachedScript = config + INPAGE_PROXY_SCRIPT;
+    return this.cachedScript;
+  },
+
+  /**
+   * Clear the cached script and URL (useful for testing)
+   */
+  clearCache(): void {
+    this.cachedScript = null;
+    this.cachedMockServerUrl = null;
+  },
+};
+
+export default EntryScriptProxyE2E;
diff --git a/tests/api-mocking/MockServerE2E.ts b/tests/api-mocking/MockServerE2E.ts
index ce573c6b0d6b..af9673518398 100644
--- a/tests/api-mocking/MockServerE2E.ts
+++ b/tests/api-mocking/MockServerE2E.ts
@@ -202,7 +202,7 @@ export default class MockServerE2E implements Resource {
       return;
     }
 
-    this._server = getLocal() as InternalMockServer;
+    this._server = getLocal({ cors: true }) as InternalMockServer;
     this._server._liveRequests = [];
     await this._server.start(this._serverPort);