In nrow(A_norm) * ncol(A_norm) : NAs produced by integer overflow

[haoqing12]

I am working with a particularly large dataset consisting of 2,423,133 cells and 1,091 genes. Using the ALRA, I ran into repeated warnings about integer overflow. Here’s the warning:

r$> A_norm_completed <- alra(A_norm,k=k_choice$k)[[3]]
Read matrix with 2423133 cells and 1091 genes
Getting nonzeros
Randomized SVD
Find the 0.001000 quantile of each gene
Sweep
Scaling all except for 0 columns
NA% of the values became negative in the scaling process and were set to zero
The matrix went from NA% nonzero to NA% nonzero
Warning messages:
1: In nrow(A_norm) * ncol(A_norm) : NAs produced by integer overflow
2: In nrow(A_norm) * ncol(A_norm) : NAs produced by integer overflow
3: In nrow(A_norm) * ncol(A_norm) : NAs produced by integer overflow

There doesn't seem to be a good complement of zeros.

Could you please provide any suggestions on how to mitigate this issue? Is there a recommended approach to handling large datasets with your software, or perhaps a parameter adjustment that I might not be aware of?