GSEA for EWAS

[brianchengithub]

Incorporate this package into methylize:

https://github.com/aet21/ebGSEA

Citation:
https://www.ncbi.nlm.nih.gov/pubmed/30715212
https://academic.oup.com/bioinformatics/article/35/18/3514/5305022

Gene Set Enrichment Analysis (GSEA) is a general tool to aid biological interpretation, yet its correct and unbiased implementation in the EWAS context is difficult due to the differential probe representation of Illumina Infinium DNA methylation beadchips.

ebGSEA ranks genes, not CpGs, according to the overall level of differential methylation, as assessed using all the probes mapping to the given gene. ebGSEA may exhibit higher sensitivity and specificity.
https://github.com/aet21/ebGSEA