diff --git a/CMakeLists.txt b/CMakeLists.txt
new file mode 100644
index 0000000..7a619ba
--- /dev/null
+++ b/CMakeLists.txt
@@ -0,0 +1,36 @@
+cmake_minimum_required(VERSION 3.15)
+project(${SKBUILD_PROJECT_NAME} LANGUAGES CXX)
+
+# Set C++ standard
+set(CMAKE_CXX_STANDARD 20)
+set(CMAKE_CXX_STANDARD_REQUIRED ON)
+
+# Find Python
+find_package(Python COMPONENTS Interpreter Development.Module REQUIRED)
+
+# Include directories
+set(CPYPP_INCLUDE_DIR "${CMAKE_CURRENT_SOURCE_DIR}/deps/cpypp/include")
+set(FBITSET_INCLUDE_DIR "${CMAKE_CURRENT_SOURCE_DIR}/deps/fbitset/include")
+set(LIBPARENTH_INCLUDE_DIR "${CMAKE_CURRENT_SOURCE_DIR}/deps/libparenth/include")
+
+# Platform-specific compiler flags
+if(CMAKE_SYSTEM_NAME STREQUAL "Darwin")
+  message(STATUS "Configuring for macOS (Darwin)")
+  set(CMAKE_OSX_DEPLOYMENT_TARGET "10.9")
+  add_compile_options(-stdlib=libc++)
+# elseif(MSVC)
+#   # MSVC compiler flags
+#   add_compile_options(/EHsc /bigobj /wd4996 /wd4267 /Zc:twoPhase-)
+endif()
+
+# parenth extension
+Python_add_library(_parenth MODULE
+  gristmill/_parenth.cpp
+  WITH_SOABI
+)
+target_include_directories(_parenth PRIVATE
+  ${CPYPP_INCLUDE_DIR}
+  ${FBITSET_INCLUDE_DIR}
+  ${LIBPARENTH_INCLUDE_DIR}
+)
+install(TARGETS _parenth LIBRARY DESTINATION gristmill)
diff --git a/pyproject.toml b/pyproject.toml
index d095700..7953c9e 100644
--- a/pyproject.toml
+++ b/pyproject.toml
@@ -1,6 +1,13 @@
 [build-system]
-requires = ["setuptools>=77", "wheel"]
-build-backend = "setuptools.build_meta"
+requires = ["scikit-build-core>=0.10"]
+build-backend = "scikit_build_core.build"
+
+[tool.scikit-build]
+cmake.minimum-version = "3.15"  # Minimum version of CMake
+cmake.verbose = true  # Verbose build for debugging
+# Don't create a separate subdirectory - install alongside Python source files
+wheel.packages = ["gristmill"]
+sdist.include = ["gristmill/templates/*", "deps/cpypp/include/**/*.hpp", "deps/fbitset/include/**/*.hpp", "deps/libparenth/include/**/*.hpp"]
 
 [project]
 name = "gristmill"
@@ -40,9 +47,3 @@ dev = ["pytest", "juliacall>=0.9.20"]
 
 [project.urls]
 Homepage = "https://github.com/DrudgeCAS/gristmill"
-
-[tool.setuptools]
-include-package-data = true
-
-[tool.setuptools.package-data]
-gristmill = ["templates/*"]
diff --git a/setup.py b/setup.py
deleted file mode 100644
index 080479c..0000000
--- a/setup.py
+++ /dev/null
@@ -1,41 +0,0 @@
-"""Setup script for gristmill."""
-
-import os.path
-import sys
-from setuptools import setup, find_packages, Extension
-
-
-PROJ_ROOT = os.path.dirname(os.path.abspath(__file__))
-INCLUDE_DIRS = [
-    os.path.join(PROJ_ROOT, 'deps', i, 'include')
-    for i in ['cpypp', 'fbitset', 'libparenth']
-]
-
-# Platform-specific compiler flags
-if sys.platform == "win32":
-    # MSVC compiler flags
-    COMPILE_FLAGS = ['/std:c++20']
-else:
-    # GCC/Clang compiler flags  
-    COMPILE_FLAGS = ['-std=c++20']
-    
-    # Additional flags for macOS to avoid header conflicts
-    if sys.platform == "darwin":
-        # Use libc++ standard library explicitly on macOS
-        COMPILE_FLAGS.extend([
-            '-stdlib=libc++',
-            '-mmacosx-version-min=10.9'
-        ])
-
-parenth = Extension(
-    'gristmill._parenth',
-    ['gristmill/_parenth.cpp'],
-    include_dirs=INCLUDE_DIRS,
-    extra_compile_args=COMPILE_FLAGS
-)
-
-setup(
-    packages=find_packages(),
-    ext_modules=[parenth],
-    package_data={'gristmill': ['templates/*']},
-)