Am starting testing spmup on a BIDS data set of mine and it seems that the spmup_auto_reorient is not too happy with defaced structurals (see attached check-reg: top left (before reorient) - top right (after reorient)).
I was also getting funky results on some EPI that had a restricted field of view.
I don't really have a "fix" in mind but I could make a pull request to add a manual_coregistration function that has been circulating for a while in my lab but has not found a home in a github repo yet.
